更新于：2024-11-01

trypsin-2 x trypsin-1

更新于：2024-11-01

基本信息

关联

项与 trypsin-2 x trypsin-1 相关的药物

TRIV-920

靶点

trypsin-1 x trypsin-2

作用机制

trypsin-1 inhibitors [+1]

在研机构

Triveni Bio, Inc.

原研机构

Triveni Bio, Inc.

在研适应症

遗传性胰腺炎

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 trypsin-2 x trypsin-1 相关的临床结果

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100 项与 trypsin-2 x trypsin-1 相关的转化医学

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0 项与 trypsin-2 x trypsin-1 相关的专利（医药）

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项与 trypsin-2 x trypsin-1 相关的文献（医药）

2024-05-01·Journal of Clinical Lipidology

Pancreatitis polygenic risk score is associated with acute pancreatitis in multifactorial chylomicronemia syndrome

Article

作者: Bouchard, Luigi ; Desgagné, Véronique ; Taschereau, Amélie ; Baass, Alexis ; Bernard, Sophie ; Guay, Simon-Pierre ; Paquette, Martine

BACKGROUNDMultifactorial chylomicronemia syndrome (MCS) is a severe form of hypertriglyceridemia associated with an increased risk of acute pancreatitis (AP). The risk of AP is heterogenous and is associated with increased level of triglycerides (TG) and presence of rare variants in TG metabolism-related genes.OBJECTIVETo determine if the accumulation of common variants in pancreatitis susceptibility genes, measured with a weighted polygenic risk score (PRS), is associated with AP in MCS patients.METHODSA total of 114 patients with MCS underwent genetic testing for eight single nucleotide polymorphisms (SNPs) in known pancreatitis susceptibility genes (ABCG8, CLDN2, CTRB1/2, CTRC, PRSS1, PRSS2, SPINK1 and TWIST2). A weighted PRS was calculated to account for the phenotypic effect of each SNP locus.RESULTSA high pancreatitis-PRS score (≥ 0.44) was associated with a 2.94-fold increase risk of AP (p = 0.02) among patients with MCS. MCS patients with a high pancreatitis-PRS and a rare variant in TG metabolism-related gene have a 9.50-fold increase risk of AP (p = 0.001), compared to those with a low-PRS and no rare variant. A multivariate analysis including the presence of rare variants, the maximal TG values and a high pancreatitis-PRS explained 26% of the variability in AP in MCS patients.CONCLUSIONThis study shows for the first time that the accumulation of common variants in pancreatitis susceptibility genes is associated with AP in MCS patients. Pancreatitis-PRS could help clinicians to identify MCS patients who may be at higher risk of AP and who may benefit from more aggressive treatment.

2024-01-01·Archives of Insect Biochemistry and Physiology

Molecular characterization and functional analysis of a beta‐1,3‐glucan recognition protein from oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae)

Article

作者: Cao, Jinjun ; Li, Weihai ; Cao, Zhishan ; Vlasenko, Volodymyr ; Bakumenko, Olha

AbstractThe beta‐1,3‐glucan recognition protein (BGRP) is an important pattern recognition protein (PRP), which plays an important role in immune recognition and signaling pathway of insect innate immunity. Herein, a BGRP gene was obtained from the transcriptome of Grapholita molesta and its expression was verified by PCR. The full cDNA of the GmBGRP gene was 1691 bp encoding 486 amino acid residues. The calculated molecular mass of the mature protein was 54.83 kDa with an estimated pI of 6.14. The amino acid sequence of GmBGRP was highly homologous to BGRPs of other lepidopterans including Leguminivora glycinivorella BGRP‐3. Expression profile of GmBGRP at different developmental stages and different tissues of 5th instar larvae showed that the expression level of this gene tends to slightly increase and then decrease at the adult stage, with the highest at the pupa stage; and mainly expressed in the epidermis, fat body and hemocytes compared with other tissues. In addition, we investigated the transcription levels of other immune‐related genes, such as Serine‐1, Serine‐2, Serine‐3, Serpin, SRCB (scavenger receptor gene), Toll, PPO (prophenoloxidase) upon GmBGRP gene silencing, indicating that GmBGRP expression is associated with immune responses of G. molesta. This was further supported by the upregulation of the mRNA level of GmBGRP following fungal infection. Taken together, these results provide experimental evidence for the role of GmBGRP gene in immune defense in G. molesta larvae.

2023-12-01·Global Medical Genetics

Genetics and Genomics of Chronic Pancreatitis with a Focus on Disease Biology and Molecular Pathogenesis

Review

作者: Shariff, Sanobar ; Chakrabarty, Soura ; Bardhan, Mainak ; Khan, Erum

AbstractChronic pancreatitis is a long-term fibroinflammatory condition of the pancreas with varying incidences across countries. The recent increase in its occurrence implies the involvement of genetic, hereditary, and unconventional risk factors. However, there is a lack of updated literature on recent advances in genetic polymorphisms of chronic pancreatitis. Therefore, this review aims to present recent findings on the genetic implications of chronic pancreatitis based on individual gene mechanisms and to discuss epigenetics and epistasis involved in the disease. Four mechanisms have been implicated in the pathogenesis of chronic pancreatitis, including premature activation of proteases, endoplasmic reticulum stress, ductal pathway dysfunction, and inflammatory pathway dysfunction. These mechanisms involve genes such as PRSS1, PRSS2, SPINK, CEL, PNLIP, PNLIPRP2, CFTR, CaSR, CLDN2, Alpha 1 antitrypsin, and GGT1. Studying genetic polymorphisms on the basis of altered genes and their products may aid clinicians in identifying predispositions in patients with and without common risk factors. Further research may also identify associations between genetic predispositions and disease staging or prognosis, leading to personalized treatment protocols and precision medicine.