别名 D(2C) dopamine receptor、D(4) dopamine receptor、D4DR + [3] |
简介 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). |
作用机制 5-HT1A receptor激动剂 [+2] |
在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2015-08-18 |
作用机制 5-HT1A receptor部分激动剂 [+6] |
最高研发阶段临床3期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 5-HT2A receptor调节剂 [+1] |
在研机构 ANeuroTech BV初创企业 |
原研机构 ANeuroTech BV初创企业 |
在研适应症 |
非在研适应症- |
最高研发阶段临床3期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2022-01-24 |
开始日期2021-07-02 |
申办/合作机构 |
开始日期2020-05-08 |
申办/合作机构 |