别名 Transient receptor potential cation channel subfamily V member 3、transient receptor potential cation channel, subfamily V, member 3、TrpV3 + [3] |
简介 Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). |
靶点 |
作用机制 TRPV3拮抗剂 |
非在研适应症- |
最高研发阶段临床1期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 TRPV3 modulators |
在研机构 |
原研机构 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 TRPV3拮抗剂 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2023-03-06 |
申办/合作机构 |
开始日期2022-07-17 |
申办/合作机构 |
开始日期2022-05-24 |
申办/合作机构 Kamari Pharma Ltd. [+1] |