A Randomized, Double-blind, Placebo-controlled Study to Assess the Safety, Pharmacokinetics and Efficacy of MAU868 for the Treatment of BK Viremia in Kidney Transplant Recipients (Neutra4)

This clinical research study will test the safety and efficacy of the investigational medication MAU868, compared to a placebo, in patients who have had a kidney transplant who have active BK virus.

开始日期2020-08-05

申办/合作机构

Vera Therapeutics, Inc.

NCT03456999 / Withdrawn临床2期

A Randomized, Double Blind, Placebo Controlled Study to Assess the Safety, Tolerability, and Efficacy of MAU868 for the Prevention of Allograft-threatening BK Virus Infection in Kidney Transplant Recipients

This study is being conducted to determine whether MAU868 warrants further clinical development for the prevention of BKV infection in kidney transplant recipients.

开始日期2018-10-15

申办/合作机构

Novartis Pharmaceuticals Corp.

100 项与病毒衣壳蛋白VP1 相关的临床结果

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100 项与病毒衣壳蛋白VP1 相关的转化医学

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0 项与病毒衣壳蛋白VP1 相关的专利（医药）

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142

项与病毒衣壳蛋白VP1 相关的文献（医药）

2024-10-01·Molecular Therapy

T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8

Article

作者: Thalheimer, F B ; Grimm, D ; Günther, D M ; Demircan, M B ; Gorol, J M ; Zinser, L J ; Theuerkauf, S A ; Michels, A ; Guaza-Lasheras, M ; Chlanda, P ; John, F ; Buchholz, C J ; Greten, F R

One of the biggest challenges for in vivo gene therapy are vectors mediating highly selective gene transfer into a defined population of therapy-relevant cells. Here we present DARPin-targeted AAVs (DART-AAVs) displaying DARPins specific for human and murine CD8. Insertion of DARPins into the GH2/GH3 loop of the capsid protein 1 (VP1) of AAV2 and AAV6 resulted in high selectivity for CD8-positive T cells with unimpaired gene delivery activity. Remarkably, the capsid core structure was unaltered with protruding DARPins detectable. In complex primary cell mixtures, including donor blood or systemic injections into mice, the CD8-targeted AAVs were by far superior to unmodified AAV2 and AAV6 in terms of selectivity, target cell viability and gene transfer rates. In vivo, up to 80% of activated CD8+ T cells were hit upon a single vector injection into conditioned humanized or immunocompetent mice. While gene transfer rates decreased significantly under non-activated conditions, genomic modification selectively in CD8+ T cells was still detectable upon Cre delivery into indicator mice. In both mouse models, selectivity for CD8+ T cells was close to absolute with exceptional detargeting from liver. The CD8-AAVs described here expand strategies for immunological research and in vivo gene therapy options.

2023-08-03·Animals : an open access journal from MDPI

Molecular Identification of Enteric Viruses in Domestic Animals in Northeastern Gabon, Central Africa.

Article

作者: Maganga, Gael Darren ; Mombo, Illich Manfred ; N'dilimabaka, Nadine ; Fritz, Matthieu ; Becquart, Pierre ; Rieu, Océane ; Bohou Kombila, Linda ; Leroy, Eric M ; Garcia, Déborah ; Lenguiya, Léadisaelle Hosanna ; Engone Ondo, Jéordy Dimitri ; Ndong Mebaley, Telstar ; Boundenga, Larson

Astroviruses (AstVs), enteroviruses (EVs), and caliciviruses (CaVs) infect several vertebrate taxa. Transmitted through the fecal-oral route, these enteric viruses are highly resistant and can survive in the environment, thereby increasing their zoonotic potential. Here, we screened for AstVs, EVs, and CaVs to investigate the role of domestic animals in the emergence of zoonoses, because they are situated at the human/wildlife interface, particularly in rural forested areas in Central Africa. Rectal swabs were obtained from 123 goats, 41 sheep, and 76 dogs in 10 villages located in northeastern Gabon. Extracted RNA reverse-transcribed into cDNA was used to detect AstVs, EVs, and CaVs by amplification of the RNA-dependent RNA polymerase (RdRp), or capsid protein (VP1) gene using PCR. A total of 23 samples tested positive, including 17 goats for AstVs, 2 goats, 2 sheep, 1 dog for EVs, and 1 dog for CaVs. Phylogenetic analyses revealed that AstV RdRp sequences clustered with sheep-, goat-, or bovine-related AstVs. In addition, one goat and two sheep VP1 sequences clustered with caprine/ovine-related Evs within the Enterovirus G species, and the CaV was a canine vesivirus. However, human-pathogenic Evs, EV-B80 and EV-C99, were detected in goats and dogs, raising questions on the maintenance of viruses able to infect humans.

2023-04-20·mSphere

Characterization of a Novel Orbivirus from Cattle Reveals Active Circulation of a Previously Unknown and Pathogenic Orbivirus in Ruminants in Kenya

Article

作者: Slothouwer, Inga ; Venter, Marietjie ; Tchouassi, David P. ; Torto, Baldwyn ; Getugi, Caroline ; Langat, Solomon ; Sang, Rosemary ; Kopp, Anne ; Junglen, Sandra ; Omoga, Dorcus C. A. ; Eibner, Georg ; Ogola, Edwin O.

The genus Orbivirus contains several viruses that cause large outbreaks in wild and domestic animals. However, there is little knowledge on the contribution of orbiviruses to diseases in livestock in Africa.