更新于：2024-11-01

LZTS1 x LZTS2

更新于：2024-11-01

基本信息

关联

项与 LZTS1 x LZTS2 相关的药物

Antago-135b

靶点

LZTS1 x LZTS2

作用机制

LZTS1调节剂 [+1]

在研机构-

原研机构

台湾中央研究院

在研适应症-

非在研适应症

肿瘤

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 LZTS1 x LZTS2 相关的临床结果

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100 项与 LZTS1 x LZTS2 相关的转化医学

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0 项与 LZTS1 x LZTS2 相关的专利（医药）

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项与 LZTS1 x LZTS2 相关的文献（医药）

2011-11-01·Journal of Biological Chemistry2区 · 生物学

The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development

2区 · 生物学

Article

作者: Yue Peng ; Amrita Das ; Curtis Clark ; Daniel T. Johnson ; Zijie Sun ; Jane Lee ; Richard Luong ; Thomas J. Carroll ; William H. Tu

Members of the leucine zipper putative tumor suppressor (LZTS) family play crucial roles in transcription modulation and cell cycle control. We previously demonstrated that LZTS2 functions as a novel β-catenin-interacting protein and represses β-catenin-mediated transcription on T-cell factor/lymphoid enhancing factor. Here, we investigate the biological role of LZTS2 using newly established Lzts2 KO mice. Homozygosity for loss-of-function of the Lzts2-targeted allele resulted in severe kidney and urinary tract developmental defects, including renal/ureteral duplication, hydroureter, and hydronephrosis, which were visible prenatally. Altered ureteric bud outgrowth was identified in Lzts2 null embryos. Further analysis indicated that β-catenin subcellular localization was altered in fibroblasts isolated from Lzts2 null embryos. In addition, Wnt growth factor-induced β-catenin-mediated transcriptional activity was increased in Lzts2 null fibroblasts, suggesting a direct role for Lzts2 in the Wnt signaling pathway. These data demonstrate a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of β-catenin-mediated nephrogenesis.

2001-10-11·Oncogene1区 · 医学

LAPSER1: a novel candidate tumor suppressor gene from 10q24.3

1区 · 医学

Article

作者: Yofre Cabeza-Arvelaiz ; Jorge L. Sepulveda ; Timothy C. Thompson ; A. Craig Chinault

Numerous LOH and mutation analysis studies in different tumor tissues, including prostate, indicate that there are multiple tumor suppressor genes (TSGs) present within the human chromosome 8p21-22 and 10q23-24 regions. Recently, we showed that LZTS1 (or FEZ1), a putative TSG located on 8p22, has the potential to function as a cell growth modulator. We report here the cloning, gene organization, cDNA sequence characterization and expression analysis of LAPSER1, an LZTS1-related gene. This gene maps within a subregion of human chromosome 10q24.3 that has been reported to be deleted in various cancers, including prostate tumors, as frequently as the neighboring PTEN locus. The complete LAPSER1 cDNA sequence encodes a predicted protein containing various domains resembling those typically found in transcription factors (P-Box, Q-rich and multiple leucine zippers). LAPSER1 is expressed at the highest levels in normal prostate and testis, where multiple isoforms are seen, some of which are either undetectable or differentially expressed in some prostate tumor tissues and cell lines. Over-expression of LAPSER1 cDNA strongly inhibited cell growth and colony-forming efficiencies of most cancer cells assessed. Together these data suggest that LAPSER1 is another gene involved in the regulation of cell growth whose loss of function may contribute to the development of cancer.

Oncology Reports3区 · 医学

In silico characterization of LZTS3, a potential tumor suppressor

3区 · 医学

Article

作者: Lohse, Ansgar W. ; Galle, Peter R. ; Teufel, Andreas ; Weinmann, Arndt

Members of the leucine zipper tumor suppressor (LZTS) protein family are thought to play roles in cell growth modulation. The two currently known members were identified by analyzing genomic and chromosomal alterations reported to be either involved or deleted in various types of cancer, suggesting a causative relationship. By means of computational biology, we have now identified a novel member of the LZTS protein family named LZTS3. The corresponding gene was localized to chromosome 20p13 and consisted of three exons. The novel LZTS3 protein demonstrated a high similarity to LAPSER1/LZTS2 and FEZ1/LZTS1, two members of the LZTS family. The conserved FEZ1 domain contains a leucine zipper motif similar to the cAMP-responsive activating transcription factor 5. As FEZ1 inhibits cancer cell growth through the regulation of mitosis and its alteration resulted in abnormal cell growth, the LZTS3 protein was expected to have similar functions during cancer differentiation. Furthermore, the protein was conserved in vertebrates, as orthologs could be identified in mouse, rat, and zebrafish. The intracellular localization of the LZTS3 protein was predicted to be nuclear by means of Reinhardt's neural network and the k-nearest neighbor algorithm. An RT-PCR-based expression profile available from the human unidentified gene-encoded (HUGE) database demonstrated the highest expression in the brain and kidney, accompanied by lower expression in multiple other tissues.