更新于：2024-11-01

PFKFB1

更新于：2024-11-01

基本信息

别名

6-phosphofructo-2-kinase、6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1、6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

+ [7]

简介

Synthesis and degradation of fructose 2,6-bisphosphate.

关联

项与 PFKFB1 相关的药物

5-MPN

靶点

PFKFB1

作用机制

PFKFB1抑制剂

在研机构

University of Louisville

原研机构

University of Louisville

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 PFKFB1 相关的临床结果

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100 项与 PFKFB1 相关的转化医学

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0 项与 PFKFB1 相关的专利（医药）

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236

项与 PFKFB1 相关的文献（医药）

2024-01-01·Saudi Journal of Biological Sciences

Prognostic significance and expression pattern of glucose related genes in breast cancer: A comprehensive computational biology approach

Article

作者: Alshehri, Bader

Breast cancer (BC) is the most common type of malignancy globally and the main reason why women die from tumours. The Warburg effect, a characteristic of tumor, describes how most solid tumour cells acclimatize to their diverse surroundings by relying heavily on aerobic glycolysis for production of energy. In addition to producing key metabolic intermediates that are crucial for the production of macromolecules, which enable cancer cell division, invasiveness, and drug resistance, the transformed energy metabolism also supplies tumor cells with ATP for cellular energy. Here, we evaluated the expression profile, prognostic significance, and clinical relevance of glucose-related genes in BC using a bioinformatic approach. To clarify the significance of glucose-related genes in the development of breast tumours, we also performed a functional enrichment investigation of deregulated genes using the STRING and KEGG portal. The study depicted that of the 61 genes examined, 8 genes had a fold change

2022-02-03·The Journals of Gerontology: Series A1区 · 医学

Age-Related Increase in Lactate Dehydrogenase Activity in Skeletal Muscle Reduces Life Span inDrosophila

1区 · 医学

Article

作者: Demontis, Fabio ; Hunt, Liam C

AbstractMetabolic adaptations occur with aging but the significance and causal roles of such changes are only partially known. In Drosophila, we find that skeletal muscle aging is paradoxically characterized by increased readouts of glycolysis (lactate, NADH/NAD+) but reduced expression of most glycolytic enzymes. This conundrum is explained by lactate dehydrogenase (LDH), an enzyme necessary for anaerobic glycolysis and whose expression increases with aging. Experimental Ldh overexpression in skeletal muscle of young flies increases glycolysis and shortens life span, suggesting that age-related increases in muscle LDH contribute to mortality. Similar results are also found with overexpression of other glycolytic enzymes (Pfrx/PFKFB, Pgi/GPI). Conversely, hypomorphic mutations in Ldh extend life span, whereas reduction in PFK, Pglym78/PGAM, Pgi/GPI, and Ald/ALDO levels shorten life span to various degrees, indicating that glycolysis needs to be tightly controlled for optimal aging. Altogether, these findings indicate a role for muscle LDH and glycolysis in aging.

2021-04-01·Biophysical Journal2区 · 生物学

Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo

2区 · 生物学

Article

作者: Shavanie Prashad ; Ian J. Gonzalez ; SoRi Jang ; Hee Soo Kim ; Avinash Patel ; Daniel A. Colón-Ramos ; Zhao Xuan ; Milind Singh ; Dirk R. Albrecht ; Anthony A. Hyman ; Ross C. Lagoy ; Louise M. Jawerth

Although much is known about the biochemical regulation of glycolytic enzymes, less is understood about how they are organized inside cells. We systematically examine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans. We determine that endogenous PFK-1.1 localizes to subcellular compartments in vivo. In neurons, PFK-1.1 forms phase-separated condensates near synapses in response to energy stress from transient hypoxia. Restoring animals to normoxic conditions results in cytosolic dispersion of PFK-1.1. PFK-1.1 condensates exhibit liquid-like properties, including spheroid shapes due to surface tension, fluidity due to deformations, and fast internal molecular rearrangements. Heterologous self-association domain cryptochrome 2 promotes formation of PFK-1.1 condensates and recruitment of aldolase/ALDO-1. PFK-1.1 condensates do not correspond to stress granules and might represent novel metabolic subcompartments. Our studies indicate that glycolytic protein PFK-1.1 can dynamically form condensates in vivo.