更新于：2024-11-01

mixed first degree burns

一度混合烧伤

更新于：2024-11-01

基本信息

别名

mixed first degree burns、mixed first degree burns (physical finding)

简介-

关联

项与一度混合烧伤相关的药物

Germinal Peptide

生发肽

靶点

thymosin beta 4

作用机制

thymosin beta 4激动剂

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与一度混合烧伤相关的临床试验

CTR20180772 / Completed临床1期

评价生发肽滴眼液在健康志愿者中耐受性、安全性和药代动力学特征的I期临床试验

评价生发肽滴眼液在中国健康志愿者的安全性和耐受性，以及在健康志愿者体内的药代动力学特征。

开始日期2018-10-29

申办/合作机构

兆科药业（合肥）有限公司

NCT01935206 / Completed临床1期IIT

Effect of a High-dose Naloxone Infusion on Secondary Hyperalgesia After a First-degree Burn

Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
Animal studies have shown reinstatement of mechanical hypersensitivity following naloxone administration after resolution of an injury. This suggests latent sensitization.
In the present study, investigators hypothesize that naloxone (2 mg/kg) can reinstate secondary hyperalgesia 168 hours after a first-degree burn-injury. Investigators aim therefore to show that latent sensitization is present in humans and is modulated by endogenous opioids.

开始日期2013-06-01

申办/合作机构

Rigshospitalet

EUCTR2012-005663-27-DK / Not yet recruitingN/AIIT

Effect of a late naloxone-infusion on secondary hyperalgesia after a first degree heat injury. - High dose naloxone: effect on secondary hyperalgesia

开始日期2013-02-27

申办/合作机构-

100 项与一度混合烧伤相关的临床结果

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100 项与一度混合烧伤相关的转化医学

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0 项与一度混合烧伤相关的专利（医药）

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项与一度混合烧伤相关的文献（医药）

2024-03-04·Journal of Burn Care & Research

Knowledge and Practices of Public Related to Burns Management in Saudi Arabia: A Cross-Sectional Study

Article

作者: Al Asmri, Saud ; Alsalem, Mohammed ; Alabdulqader, Khallad ; Alruwaili, Abdullah ; Alninyaa, Mohammed ; Alanazy, Ahmed ; Alibrahim, Mohammed

AbstractBurn injuries are a significant global health challenge, with physical and psychological consequences affecting 180 000 people annually. This study aimed to evaluate public knowledge and practices regarding burn management. This cross-sectional survey included 582 participants to assess their knowledge and practices related to burn management between January 2023 and May 2023. Non-healthcare participants in Al Ahsa city in Saudi Arabia were asked questions about demographic data on age, sex, education, and nationality, along with assessing knowledge of burn first aid, sources of information, awareness of burn degree, chemical burn management, personal burn exposure, and traditional treatments. Our study of 582 participants highlighted significant findings related to sex and educational levels in burn management knowledge and practice. Females were more likely to receive information about burn first aid (69.3%), with a preference for social media as their information source, while males favored official courses (31.3%). Males displayed higher self-perceived knowledge were more inclined to consider first-degree burns the most dangerous (44.7%) and were better informed about managing chemical burns (24.2%). Females reported higher burn exposure (72.5%) and were more likely to manage burns themselves (76.5%). Informed participants with prior knowledge exhibited a greater interest in learning more about burn first aid (97%) and were more knowledgeable about burn degree and chemical burn management. These findings underscore the importance of tailoring public health education to burn first aid based on sex and education level. Such targeted approaches can enhance population-level preparedness and reduce burn injuries’ affect more effectively.

2023-09-01·Burns

The effects of the posttraumatic stress and general health status on paediatric burns and their sleep habits

Article

作者: Düken, Mehmet Emin ; Zengin, Mürşide ; Yayan, Emriye Hilal ; Sevgi, Tekcan

BACKGROUNDBurns are serious injuries that can require hospitalization and have physical and emotional sequelae. Sleep disturbance can occur after trauma as evidenced by posttraumatic stress symptoms such as re-experiencing of a trauma with repetitive dreams, memories and flashbacks. This area has been minimally examined with pediatric burn survivors; therefore, the aim of this study was to investigate the effects of posttraumatic stress and general health on sleep habits of pediatric burn survivors from.METHODThis is a correlational descriptive study. Its sample included 7-18-year-old inpatients at the burn clinic of a university hospital from January to November 2019. This study used the Posttraumatic Stress Disorder Reaction Index, the General Health Questionnaire (12) and the Children's Sleep Habits Questionnaire for data collection.RESULTSOf the participants, 58.6% were male, 46.5% were primary school students, and 62.6% had no diseases other than their burns. 20.2% of the children had epilepsy, 14.2% had diabetes and 3% had pneumonia. Of the child burn victims, 45.5% were brought to the hospital because of contact with fire. All of them had first-degree burns, 59.6% had second-degree burns, and 80.8% had third-degree burns. After their burns, infections developed in 20.2% during trauma and in 43.4% during burn treatment. A structural equation model indicated that the child burn victims' general health perceptions did not significantly affect their sleep habits (p > 0.05). A significant correlation was found between the children's posttraumatic stress disorder and their sleep habits (p < 0.05). Posttraumatic stress disorder explained 7.2% of their sleep habits. A positive and significant correlation was found between the children's general health perceptions and posttraumatic stress disorder (r = 0.74, p < 0.05).CONCLUSIONBurns of any kind can cause posttraumatic stress, sleep disorders and impairment of health status in children.

2023-08-13·Journal of clinical medicine

Outcome of Facial Burn Injuries Treated by a Nanofibrous Temporary Epidermal Layer.

Article

作者: Cirebea, Jan ; Wang, Anna ; Kim, Bong-Sung ; Buehler, Philipp ; Vasella, Mauro ; Waldner, Matthias ; Gousopoulos, Epameinondas ; Schweizer, Riccardo ; Grieb, Gerrit ; Plock, Jan Alexander

BACKGROUNDThe face is commonly affected in thermal injuries, with a demand for proper recognition and the correct choice of treatment to guarantee optimal aesthetic and functional outcomes. It is highly vascularized and often heals conservatively, highlighting the particular relevance of conservative treatment modalities, many of which require daily re-applications or dressing changes, which can be painful and tedious for both the patient and the healthcare providers. Motivated by encouraging results of a novel temporary nanofibrous epidermal layer, we herein present a case series of this technology in a case series of patients suffering from facial burns and treated in our Burn Center.PATIENTS AND METHODSPatients with superficial partial-thickness facial burns and mixed pattern burns, which were treated with SpinCare^™, an electrospun nanofibrous temporary epidermal layer, between 2019 and 2021, at our institution were analyzed retrospectively. The Manchester scar scale (MSS) and numeric rating scale (NRS) were used for scar, pain, and outcome evaluation at different time points by five independent board-certified plastic surgeons with profound experience in burn surgery.RESULTSTen patients (m = 9; f = 1) were treated and evaluated retrospectively. The mean age was 38.8 ± years (SD ± 17.85). The mean healing time was 6.4 days (SD ± 1.56). The mean follow-up was 16.4 months (SD ± 11.33). The mean MSS score was 5.06 (SD ± 1.31), and the mean NRS Score for pain was significantly reduced from initially 7 to 0.875 upon application (mean (pre-application) 7 ± 0.7 and (application) 0.875 ± 1.26; p ≤ 0.0001). Patients reported a NRS score of 10 in terms of functional and cosmetic outcomes at their final follow-up appointment. No adverse effects were observed.CONCLUSIONSThe application of a nanofibrous temporary epidermal layer such as SpinCare^™ represents a relatively easy-to-use, well-tolerated, and effective alternative for the treatment of partial-thickness facial burns.