更新于：2024-11-01

Chronic purulent otitis media

慢性化脓性中耳炎

更新于：2024-11-01

基本信息

别名

CSOM - Chronic suppurative otitis media、Chronic Suppurative Otitis Media、Chronic non-suppurative otitis media with effusion - purulent

+ [21]

简介

Otitis media that persists for at least six weeks, and that is associated with otorrhea through a perforated tympanic membrane.

关联

项与慢性化脓性中耳炎相关的药物

Pazufloxacin Mesilate

甲磺酸帕珠沙星

靶点

Bacterial DNA gyrase x Topoisomerase IV

作用机制

细菌DNA旋转酶复合体抑制剂 [+1]

在研机构

湖南华纳大药厂手性药物有限公司 [+4]

原研机构

Taisho Toyama Pharmaceutical Co., Ltd.

在研适应症

感染 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2002-04-11

154

项与慢性化脓性中耳炎相关的临床试验

CTRI/2023/11/060365 / Not yet recruitingN/AIIT

COMPARISION OF CISATRACURIUM VERSUS ROCURONIUM FOR RAPID SEQUENCE INTUBATION

开始日期2024-12-15

申办/合作机构

Vinayaka Missions University

CTRI/2024/10/074840 / Not yet recruitingN/AIIT

A Comparative study of myringoplasty with and without cortical mastoidectomy in treatment of chronic otitis media without choleasteatoma - nil

开始日期2024-10-18

申办/合作机构

Dr. Rajendra Prasad Government Medical College

CTRI/2024/09/074471 / Not yet recruiting临床2期IIT

Clinical Evaluation Of Kshaumadi Karnadhoopana And Rasnaadi Guggulu in Karnasrava (Chronic Suppurative Otitis Media) - Nil

开始日期2024-10-08

申办/合作机构-

100 项与慢性化脓性中耳炎相关的临床结果

登录后查看更多信息

100 项与慢性化脓性中耳炎相关的转化医学

登录后查看更多信息

0 项与慢性化脓性中耳炎相关的专利（医药）

登录后查看更多信息

2,874

项与慢性化脓性中耳炎相关的文献（医药）

2024-11-01·Microbial Pathogenesis

Anaerobic bacteria dominate the cholesteatoma tissue of chronic suppurative otitis media patients

Article

作者: Biswas, Kristi ; Neeff, Michel ; Douglas, Richard G. ; Douglas, Richard G ; Broderick, David

The aim of this study was to investigate both the microbial composition and absolute abundance of clinically relevant bacteria in tissue specimens from patients with chronic suppurative otitis media with cholesteatoma (CSOM with cholesteatoma). Mastoid mucosa and cholesteatoma tissue from eleven subjects with CSOM with cholesteatoma, and mastoid mucosa from ten controls were examined using standard hospital culture swabs, Gram staining, bacterial 16S rRNA gene sequencing, Droplet Digital PCR (ddPCR), and multiplex PCR. Positive results from culture swabs were reported in half the CSOM with cholesteatoma samples and 1 control sample. In contrast, ddPCR detected bacterial genes copies in all 11 mucosa and cholesteatoma of CSOM subjects and 3 control samples. The average bacterial gene copies in tissue samples with CSOM with cholesteaotoma (1.6 ± 0.7 log10) was significantly higher compared to healthy controls (0.3 ± 1.6). These results were corroborated with Gram-staining that identified the large presence of Gram-positive cocci cells in the cholesteatoma tissue of CSOM subjects which were not seen in the mucosa of controls. The most abundant genus detected by sequencing in the mucosa and cholesteatoma of CSOM samples was Anaerococcus (93.5 % of all reads), and genus Meiothermus (0.9 %) in the control sample. The 3 samples with the highest sequencing reads (>300) were further analysed using multiplex PCR to identify the dominant Anaerococcus species. Anaerococcus hydrogenalis was the dominant species identified in these samples. In contract, commonly named ear pathogens, genera Staphylococcus and Pseudomonas, were detected in low numbers (<0.001 % of all sequencing reads) and low prevalence (2/16 samples) in the tissue samples of this study. The results show that culture severely underestimated the bacterial diversity in CSOM samples and investigating tissue rather than standard culture swabs might be advantageous to understanding the disease process. The high abundance of bacteria and the large presence of Gram-positive cells detected in the cholesteatoma tissue of CSOM compared to mucosa of CSOM or controls could be members from the genus Anaerococcus. Anaerococcus may well be a pathogen in CSOM with cholesteatoma, but their role in this condition requires further investigation.

2024-11-01·International Journal of Surgery Case Reports

Bezold's abscess in tuberculous otitis media: An extremely rare case report and literature review

Article

作者: Sulistyo, Hidayat ; Darmawan, Anton Budhi ; Darmayan, Bella Jovita

INTRODUCTIONBezold's abscess is a rare complication of chronic suppurative otitis media since the advent of antibiotics. Otitis media can also result from uncommon infections such as tuberculosis, with a diagnosis often delayed due to clinical symptoms that closely resemble other chronic middle ear conditions.CASE REPORTWe present a case of Bezold's abscess as a complication of primary tuberculous otitis media in a 21-year-old male who reported right-sided neck swelling for four days, accompanied by fever, difficulty opening his mouth, and a history of persistent purulent discharge in both ears for six months that did not respond to topical antibiotics.DISCUSSIONThis case underscores the diagnostic challenges of tuberculous otitis media, an unusual form of extrapulmonary tuberculosis that can closely mimic other types of chronic otitis media. The atypical presentation and low incidence of TOM contribute to frequent delays in diagnosis, highlighting the need for increased clinical vigilance, particularly in cases of persistent otorrhea unresponsive to standard antimicrobial therapy. Prompt recognition and initiation of appropriate antituberculous treatment, along with surgical intervention when indicated, are essential to prevent severe complications. This case illustrates the importance of considering TOM in the differential diagnosis of chronic ear infections and the value of advanced diagnostic modalities in facilitating early and accurate identification.CONCLUSIONTuberculous otitis media should be considered when optimal treatment regimens fail to achieve expected outcomes. Prompt diagnosis is essential in avoiding delays in treatment, which can lead to severe complications such as Bezold's abscess.

2024-11-01·Clinical Otolaryngology

The Prognostic Value of Active Otitis Media on Tympanoplasty Success Rate—A Systematic Review

Review

作者: Namba, Hanae Fumiyo ; Plug, Mariëlle Bernadette ; Smit, Adriana Leni

ABSTRACTObjectivesThe aim is to investigate the influence of an active otitis media on the success rate of tympanoplasty in patients with a chronic otitis media (COM) and a tympanic membrane perforation.Databases ReviewedPubMed, Embase and the Cochrane Library.MethodsThe inclusion criteria were studies on closure rates of tympanoplasty performed in COM patients of any age with a tympanic membrane perforation caused by COM. The exclusion criteria were studies on patients undergoing concomitant mastoidectomy, ossicular chain reconstruction, tuboplasty, adenoidectomy, revision tympanoplasty, patients with perforations due to other conditions than COM, and letters to editors, commentaries, conference abstracts and case reports. The included articles were critically appraised using the QUIPS tool. Data on tympanic membrane closure rate were extracted, odds ratio (OR) and 95% confidence intervals (CI) of the closure rate with a wet versus a dry ear were calculated.ResultsThe search was performed on 1 February 2023. Of 4671 articles, 16 studies were included and critically appraised. Of these observational studies (nine prospective, seven retrospective), with a total of 1509 patients (dry ear group n = 1003; wet ear group n = 506), two studies stated a significant difference in success rate, one in favour of a dry ear and one in favour of a wet ear at time of surgery. All other studies did not show a statistically significant difference. Overall, the risk of bias was considered moderate to high.ConclusionsWe found no significant prognostic value of having an active otitis media during tympanoplasty on tympanic membrane closure rates. Because the overall risk of bias was considered moderate to high, no strong conclusions can be made. To be able to answer this question with higher levels of evidence, high‐quality prospective or randomized studies are needed.