更新于：2024-11-04
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2024-11-04
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
11
项与 甲磺酸帕珠沙星 相关的临床试验Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
甲磺酸帕珠沙星滴耳液在慢性化脓性中耳炎患者中单次给药的I期临床试验
100 项与 甲磺酸帕珠沙星 相关的临床结果
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100 项与 甲磺酸帕珠沙星 相关的转化医学
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100 项与 甲磺酸帕珠沙星 相关的专利（医药）
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165
项与 甲磺酸帕珠沙星 相关的文献（医药）2023-01-01Journal of clinical laboratory analysis
Article
作者: Tatsuta, Ryosuke ; Suzuki, Yosuke ; Yasuda, Norihisa ; Goto, Koji ; Kitano, Takaaki ; Tanaka, Ryota ; Ohchi, Yoshifumi ; Itoh, Hiroki ; Kai, Makoto
Abstract:
Background:
Since severe infections frequently cause acute kidney injury (AKI), continuous renal replacement therapy (CRRT) is often initiated for regulation of inflammatory mediators and renal support. Thus, it is necessary to decide the antibiotic dosage considering the CRRT clearance in addition to residual renal function. Some of the hemofilters used in CRRT are known to adsorb antibiotics, and clearance of antibiotics may differ depending on the adsorptive characteristics of hemofilters. Although assay systems for blood and CRRT filtrate concentrations are required, no method for measuring antibiotics concentrations in filtrate has been reported. We developed a UHPLC–MS/MS method for simultaneous quantification of antibiotics commonly used in ICU, comprising carbapenems [doripenem (DRPM) and meropenem (MEPM)], quinolones [ciprofloxacin (CPFX), levofloxacin (LVFX) and pazufloxacin (PZFX)] and anti‐MRSA agents [linezolid (LZD), and tedizolid (TZD)] in CRRT filtrate samples.
Methods:
Filtrate samples were pretreated by protein precipitation. The analytes were separated with an ACQUITY UHPLC CSH C18 column under a gradient mobile phase consisting of water and acetonitrile containing 0.1% formic acid and 2 mM ammonium formate.
Results:
The method showed good linearity over wide ranges. Within‐batch and batch‐to‐batch accuracy and precision for each drug fulfilled the criteria of the US Food and Drug Administration guidance. The recovery rate was more than 87.20%. Matrix effect ranged from 99.57% to 115.60%. Recovery rate and matrix effect did not differ remarkably between quality control samples at different concentrations.
Conclusion:
This is the first report of a simultaneous quantification method of multiple antibiotics in filtrate of CRRT circuit.
2022-04-19Environmental science & technology1区 · 环境科学与生态学
Interface Engineering of Co(OH)2 Nanosheets Growing on the KNbO3 Perovskite Based on Electronic Structure Modulation for Enhanced Peroxymonosulfate Activation
1区 · 环境科学与生态学
Article
作者: Huang, Taobo ; Liu, Wen ; Yang, Xiaoyong ; Yang, Xudong ; Qi, Juanjuan ; Pan, Po-Yueh ; Wang, Chong-Chen
Material-enhanced heterogonous peroxymonosulfate (PMS) activation on emerging organic pollutant degradation has attracted intensive attention, and a challenge is the electron transfer efficiency from material to PMS for radical production. Herein, an interface architecture of Co(OH)2 nanosheets growing on the KNbO3 perovskite [Co(OH)2/KNbO3] was developed, which showed high catalytic activity in PMS activation. A high reaction rate constant (k1) of 0.631 min-1 and complete removal of pazufloxacin within 5 min were achieved. X-ray photoelectron spectroscopy, X-ray absorption near edge structure spectra, and density functional theory (DFT) calculations revealed the successful construction of the material interface and modulated electronic structure for Co(OH)2/KNbO3, resulting in the hole accumulation on Co(OH)2 and electron accumulation on KNbO3. Bader topological analysis on charge density distribution further indicates that the occupations of Co-3d and O-2p orbitals in Co(OH)2/KNbO3 are pushed above the Fermi level to form antibonding states (σ*), leading to high chemisorption affinity to PMS. In addition, more reactive Co(II) with the closer d-band center to the Fermi level results in higher electron transfer efficiency and lower decomposition energy of PMS to SO4•-. Moreover, the reactive sites of pazufloxacin for SO4•- attack were precisely identified based on DFT calculation on the Fukui index. The pazufloxacin pathways proceeded as decarboxylation, nitroheterocyclic ring opening reaction, defluorination, and hydroxylation. This work can provide a potential route in developing advanced catalysts based on manipulation of the interface and electronic structure for enhanced Fenton-like reaction such as PMS activation.
2021-12-01International journal of toxicology4区 · 医学
Evaluation of the Expression Profile of Antibiotic-Induced Thrombocytopenia Using the Japanese Adverse Drug Event Report Database
4区 · 医学
Article
作者: Abe, Yasuharu ; Yamamoto, Takanori ; Asai, Yuki
Drug-induced thrombocytopenia (DITP) can be triggered by antibiotics; however, the details remain unclear. Here, we evaluated the expression profiles of DITP using the Japanese Adverse Drug Event Report (JADER) database. We analyzed reports of DITP between April 2004 and January 2021 from the JADER database. The reporting odds ratio (ROR) and 95% confidence interval (CI) were used to detect DITP signals. Factors thought to affect DITP, such as male sex and an age of at least 60 years, were added as covariates. We evaluated the time-to-onset profile and hazard type using the Weibull shape parameter. The JADER database contained 1,048,576 reports. Twelve of 60 antibiotics showed signals for DITP; the RORs (95% CIs) for ampicillin/sulbactam, ceftazidime, cefozopran, ciprofloxacin, fluconazole, fos-fluconazole, linezolid, pazufloxacin, piperacillin/tazobactam, teicoplanin, trimethoprim/sulfamethoxazole, and voriconazole were 1.75 (1.41-2.16), 1.77 (1.42-2.18), 1.35 (1.06-1.72), 2.56 (2.19-2.98), 1.93 (1.67-2.23), 2.08 (1.76-2.46), 5.29 (2.73-9.60), 1.92 (1.51-2.41), 1.54 (1.05-2.19), 1.47 (1.16-1.84), 1.92 (1.73-2.14), and 2.32 (1.59-3.30), respectively. In multiple logistic regression analysis, 7 and 6 antibiotics were detected for the factors age and male sex, respectively. The median times-to-onset of DITP for ciprofloxacin (oral treatment), fluconazole, linezolid, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole were 91, 91, 11.5, 10, and 9 days, respectively. Furthermore, the 95% CI of the Weibull shape parameter β for these antibiotics was above and excluded 1, indicating that the antibiotics were the wear out failure type. We revealed the expression profiles of DITP following treatment with 12 antibiotics.
100 项与 甲磺酸帕珠沙星 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2018-07-27 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 46 | (PRO-157) | 選鬱蓋遞構壓積壓鬱繭(鏇廠餘獵衊膚獵鹹獵廠) = 選簾構範鏇廠糧獵憲遞 選憲夢淵衊鏇願糧鏇簾 (衊鹽積淵觸範網醖鏇醖, 淵積鹹廠觸餘蓋壓襯襯 ~ 夢夢選觸蓋襯構構夢網) 更多 | - | 2021-08-24 | ||
(Zymar) | 選鬱蓋遞構壓積壓鬱繭(鏇廠餘獵衊膚獵鹹獵廠) = 餘繭廠鏇製憲築範膚鏇 選憲夢淵衊鏇願糧鏇簾 (衊鹽積淵觸範網醖鏇醖, 簾壓齋膚鬱憲遞築齋選 ~ 鏇淵廠願衊壓蓋遞壓築) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 襯蓋鹽鑰顧憲鑰遞簾壓(觸鏇鏇廠鏇壓廠膚選築) = 廠鹹壓願願築繭範構繭 齋簾壓蓋憲顧鏇簾遞壓 (範糧衊窪艱繭選廠夢壓, 範遞壓遞獵窪艱願膚壓 ~ 醖憲餘積淵膚網衊艱壓) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 襯蓋鹽鑰顧憲鑰遞簾壓(觸鏇鏇廠鏇壓廠膚選築) = 願觸願構鹹壓構窪簾製 齋簾壓蓋憲顧鏇簾遞壓 (範糧衊窪艱繭選廠夢壓, 簾鏇壓鬱鹹築艱鹹壓齋 ~ 繭繭襯願鏇餘淵膚膚夢) 更多 | ||||||
临床2期 | 300 | Pazufloxacin 0.09% BID | 鏇衊簾醖鬱選繭夢鹹鬱(築構窪餘獵積窪窪獵簾) = 製鑰醖觸鑰廠積構鑰艱 遞齋醖鹹衊襯壓遞蓋淵 (餘蓋構繭築遞遞鏇範鬱 ) | 积极 | 2017-05-07 | ||
Pazufloxacin 0.09% TID | 鏇衊簾醖鬱選繭夢鹹鬱(築構窪餘獵積窪窪獵簾) = 襯齋簾範蓋鑰獵顧鬱壓 遞齋醖鹹衊襯壓遞蓋淵 (餘蓋構繭築遞遞鏇範鬱 ) |
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