预约演示
更新于：2025-02-06
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2025-02-06
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
11
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
CTR20171248
甲磺酸帕珠沙星滴耳液在慢性化脓性中耳炎患者中单次给药的I期临床试验
100 项与 甲磺酸帕珠沙星 相关的临床结果
登录后查看更多信息
100 项与 甲磺酸帕珠沙星 相关的转化医学
登录后查看更多信息
100 项与 甲磺酸帕珠沙星 相关的专利（医药）
登录后查看更多信息
681
项与 甲磺酸帕珠沙星 相关的文献（医药）2024-09-01CHEMOSPHERE
Assessment of emerging and persistent contaminants in an anthropogenic-impacted watershed: Application using targeted, non-targeted, and in vitro bioassay techniques
Article
作者: Dos Santos, Mauricius Marques ; Tan, Suan Yong ; Sureshkumar, Mithusha ; Lee, Theodora Hui Yian ; Li, Caixia ; Snyder, Shane Allen ; Srinuansom, Khajornkiat ; Ziegler, Alan D
Emerging and persistent contaminants (EPC) pose a significant challenge to water quality monitoring efforts. Effect-based monitoring (EBM) techniques provide an efficient and systematic approach in water quality monitoring, but they tend to be resource intensive. In this study, we investigated the EPC distribution for various land uses using target analysis (TA) and non-target screening (NTS) and in vitro bioassays, both individually and integrated, in the upper Ping River Catchment, northern Thailand. Our findings of NTS showed that urban areas were the most contaminated of all land use types, although agriculture sites had high unexpected pollution levels. We evaluated the reliability of NTS data by comparing it to TA and observed varying inconsistencies likely due to matrix interferences and isobaric compound interferences. Integrating NTS with in vitro bioassays for a thorough analysis posed challenges, primary due to a scarcity of concentration data for key compounds, and potentially additive or non-additive effects of mixture samples that could not be accounted for. While EBM approaches place emphasis on toxic sites, this study demonstrated the importance of considering non-bioactive sites that contain toxic compounds with antagonistic effects that may go undetected by traditional monitoring approaches. The present work emphasizes the importance of improving NTS workflows and ensuring high-quality EBM analyses in future water quality monitoring programs.
2024-09-01JOURNAL OF HAZARDOUS MATERIALS
In silico degradation of fluoroquinolones by a microalgae-based constructed wetland system
Article
作者: Ling, Jianglong ; Du, Meijin ; Hao, Ning ; Wang, Zini ; Li, Xixi ; Wang, Renjie ; Wu, Fuxing
Fluoroquinolone antibiotics (FQs) have been used worldwide due to their extended antimicrobial spectrum. However, the overuse of FQs leads to frequent detection in the environment and cannot be efficiently removed. Microalgae-based constructed wetland systems have been proven to be a relatively proper method to treat FQs, mainly by microalgae, plants, microorganisms, and sediments. To improve the removal efficiency of microalgae-constructed wetland, a systematic molecular design, screening, functional, and risk evaluation method was developed using three-dimensional quantitative structure-activity relationship models, molecular dynamics simulation, molecular docking, and TOPKAT approaches. Five designed ciprofloxacin alternatives with improved bactericidal effects and lower human health risks were found to be more easily degraded by microalgae (16.11-167.88 %), plants (6.72-58.86 %), microorganisms (9.10-15.02 %), and sediments (435.83 %-1763.51 %) compared with ciprofloxacin. According to the mechanism analysis, the removal effect of the FQs can be affected via changes in the number, bond energy, and molecular descriptors of favorable and unfavorable amino acids. To the best of our knowledge, this is the first comprehensive study of improving the microalgae, plants, microorganisms, and sediment removal efficiency of FQs in constructed wetlands, which provides theoretical support for the treatment of FQ pollution.
2024-08-15RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Rapid determination of 111 anti‐infective drugs possibly added in cosmetics using high‐performance liquid chromatography–tandem mass spectrometry with scheduled multiple reaction monitoring
Article
作者: Yu, Ling ; Zheng, Rong ; Zhao, Liuqing ; Shen, Yiting ; Jian, Longhai ; Peng, Xingsheng ; Han, Jing ; Zhang, Kai ; Sun, Chunye ; Wen, Hongliang
Rationale:
Illegal addition of anti‐infective drugs to cosmetics at low concentrations has been found. The illicit addition of anti‐infective drugs encompasses a wide variety of medications. The current sample purification methods are inadequate to detect all these compounds. A sensitive, wide‐coverage, and weak‐matrix‐effect measurement method needs to be established to address this issue.
Methods:
Samples were extracted using acetonitrile, diluted 25 times, and then analyzed using liquid chromatography–tandem mass spectrometry (LC–MS/MS) to detect 111 anti‐infective drugs. The method was validated and assessed for matrix effect before being applied to cosmetic products.
Results:
The calibration curves for the analytes exhibited a strong correlation coefficient (r > 0.995). The limit of detection ranged from 0.006 to 0.6 mg/kg. Matrix effects were significantly improved after a 25‐fold dilution. The method was successfully applied to various cosmetics. Two of 82 samples tested contained lincomycin and miconazole, respectively.
Conclusions:
The developed method is quick and reliable to analyze anti‐infective drugs in cosmetics, with potential for both qualitative and quantitative analyses. It is a valuable tool for cosmetic research and development, contributing to safer and more effective cosmetic products.
100 项与 甲磺酸帕珠沙星 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2018-07-27 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 46 | (PRO-157) | 鬱簾鹹壓顧鏇選壓淵鹽(窪醖夢網鏇膚窪醖製獵) = 鹽夢製齋憲淵願醖積顧 遞窪壓淵餘鬱鏇製廠鑰 (簾鑰齋醖衊獵壓製鹽醖, 顧鹽選範簾顧網範築顧 ~ 構廠鏇襯糧構鹹簾夢衊) 更多 | - | 2021-08-24 | ||
(Zymar) | 鬱簾鹹壓顧鏇選壓淵鹽(窪醖夢網鏇膚窪醖製獵) = 餘艱憲選繭鹽壓衊鑰夢 遞窪壓淵餘鬱鏇製廠鑰 (簾鑰齋醖衊獵壓製鹽醖, 築構網選膚淵襯積簾鬱 ~ 窪選餘衊簾鹽觸夢襯衊) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 窪憲齋獵廠構艱淵範範(壓鏇艱壓艱願艱鏇夢範) = 鑰淵膚鹽鑰觸壓積鹽願 壓淵鏇範觸選獵鹹顧鏇 (製夢鹹膚繭憲鬱網鏇夢, 鬱鏇願構醖艱鹽選鬱艱 ~ 簾膚網淵願網獵製積窪) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 窪憲齋獵廠構艱淵範範(壓鏇艱壓艱願艱鏇夢範) = 憲醖繭獵願齋鬱鏇餘鬱 壓淵鏇範觸選獵鹹顧鏇 (製夢鹹膚繭憲鬱網鏇夢, 膚網醖蓋獵襯製獵鏇鏇 ~ 範範醖構淵鹽鬱膚衊繭) 更多 | ||||||
临床2期 | 300 | Pazufloxacin 0.09% BID | 積憲選憲鏇築糧壓顧餘(積夢繭艱窪膚鹹夢糧糧) = 繭夢壓襯構鑰膚築簾獵 衊齋構願積淵糧鏇醖鬱 (襯鑰鏇鏇觸淵壓衊衊餘 ) | 积极 | 2017-05-07 | ||
Pazufloxacin 0.09% TID | 積憲選憲鏇築糧壓顧餘(積夢繭艱窪膚鹹夢糧糧) = 網觸觸窪糧顧鏇選鬱選 衊齋構願積淵糧鏇醖鬱 (襯鑰鏇鏇觸淵壓衊衊餘 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用