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更新于：2025-07-02
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2025-07-02
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
10
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT02592096
A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media
100 项与 甲磺酸帕珠沙星 相关的临床结果
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100 项与 甲磺酸帕珠沙星 相关的转化医学
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100 项与 甲磺酸帕珠沙星 相关的专利（医药）
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676
项与 甲磺酸帕珠沙星 相关的文献（医药）2025-08-01SEPARATION AND PURIFICATION TECHNOLOGY
Environmentally friendly synthesis of quasi-MIL-100(Fe) with modulation defects for efficient photo-Fenton degradation of ciprofloxacin
作者: Ma, Xianyun ; Zhang, Sanbing ; Liu, Yajia ; Miao, Chang-qing ; Zhu, Bowen ; Wang, Min ; Li, Zuopeng
Defect engineering is a promising approach for constructing highly efficient catalytic activity based on metal-organic frameworks (MOFs).In this study, a defective MOFs, referred to as quasi-MIL-100(Fe), was synthesized by moderate synthesis method and then careful thermal treatment at an atm. ranging from 150 to 450°C, linking crystalline materials and the associated metal oxides.MIL-100(Fe) heat-treated at 250°C (referred to as M-250) partially breaks coordination bonds, resulting in a crystalline-to-amorphous transformation, increased porosity, and elimination of ligands.Compared to pristine MIL-100(Fe), M-250 possessed more reactive sites and exhibited the highest photo-Fenton degradation of ciprofloxacin with 95.6% removal efficiency in 90 min, despite the unfavorable photo properties for photo-Fenton performance due to the destruction of the crystal structure.Addnl., d. functional theory (DFT) calculations, combined with free radical quenching and mass spectrometry anal., elucidated the catalytic mechanism.These findings highlight the significant potential of quasi-MOFs for applications in the photo-Fenton reaction.
2025-06-01CHEMICAL ENGINEERING JOURNAL
Ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads and DNA walker for ultrasensitive quantifying enrofloxacin and ciprofloxacin
作者: Yang, Junsong ; Jiang, Hongtao ; Wang, Zhouping ; Qi, Shuo ; Dong, Xiaoze ; Ang, Beijun ; Khan, Imran Mahmood
Quinolone-antibiotic residues pose serious threat to food safety and ecol. environmental health.Therefore, we have developed a ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA (ZAFT) nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads (W/Apt-Tet-MB) and DNA walker for ultrasensitive quantification of two typical quinolone antibiotics (enrofloxacin and ciprofloxacin).Firstly, a simple and stable satellite nano assembly (Zr-MOF@AuNPs) was synthesized.DNA hairpin H1-L@FAM was coupled with Zr-MOF@AuNPs to form Zr-MOF@Au@FAM (ZAF) nano assembly.Furthermore, the W/Apt-Tet-MB demonstrated excellent capturing capability for ENR and CIP due to the efficient integration of group-specific aptamer in the DNA tetrahedra.In addition to capturing targets, the walker DNA (W) was released, triggering the opening of DNA H1 on the ZAF.Supported by fuel DNA H2 and entropy-driven mechanisms, the newly exposed ssDNA region within H1 then reacted with H2 and reporter DNA (modified with Tamra) through nucleic acid hybridization to form ZAFT and release W again.Subsequently, the released W opened other nearby H1 and continuously initiated a new round of DNA walker reaction.Thus, ZAFT was generated in large quantities.Meanwhile, significant ratiometric fluorescence signals (F585/F519) were generated and pos. correlated with the amounts of targets employing the localized surface plasmon resonance (LSPR) activities of prepared Zr-MOF@AuNPs.The developed aptasensor demonstrated good linearity in the 0.001-100 ng/mL range, with a LOD of 0.24 and 0.31 pg/mL towards ENR and CIP.Importantly, the aptasensor was successfully applied to quantify ENR/CIP in real samples with satisfactory recoveries, manifesting its prospective application in environmental monitoring and food safety.
2025-04-21JOURNAL OF DRUG TARGETING
Artificial intelligence-based molecular property prediction of photosensitising effects of drugs
Article
作者: Hofmann, Amun G. ; Agibetov, Asan ; Weber, Benedikt ; Ibbotson, Sally
Drug-induced photosensitivity is a potential adverse event of many drugs and chemicals used across a wide range of specialties in clinical medicine. In the present study, we investigated the feasibility of predicting the photosensitising effects of drugs and chemical compounds via state-of-the-art artificial intelligence-based workflows. A dataset of 2200 drugs was used to train three distinct models (logistic regression, XGBoost and a deep learning model (Chemprop)) to predict photosensitising attributes. Labels were obtained from a list of previously published photosensitisers by string matching and manual validation. External evaluation of the different models was performed using the tox21 dataset. ROC-AUC ranged between 0.8939 (Chemprop) and 0.9525 (XGBoost) during training, while in the test partition it ranged between 0.7785 (Chemprop) and 0.7927 (XGBoost). Analysis of the top 200 compounds of each model resulted in 55 overlapping molecules in the external validation set. Prediction scores in fluoroquinolones within this subset corresponded well with culprit substructures such as fluorinated aryl halides suspected of mediating photosensitising effects. All three models appeared capable of predicting photosensitising effects of chemical compounds. However, compared to the simpler model, the complex models appeared to be more confident in their predictions as exhibited by their distribution of prediction scores.
100 项与 甲磺酸帕珠沙星 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2015-07-24 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 46 | (PRO-157) | 醖製鹹鬱觸選構衊襯顧 = 衊膚遞鑰範鹽膚選築衊 顧顧艱範憲壓遞鹽齋壓 (窪鹹願齋蓋餘壓醖廠鹹, 觸鏇獵築夢糧蓋夢鏇夢 ~ 窪網觸鹽衊淵範襯醖廠) 更多 | - | 2021-08-24 | ||
(Zymar) | 醖製鹹鬱觸選構衊襯顧 = 糧築鑰糧顧艱壓選鑰膚 顧顧艱範憲壓遞鹽齋壓 (窪鹹願齋蓋餘壓醖廠鹹, 齋網淵膚衊鬱構醖範鬱 ~ 鹹獵鬱憲顧鑰窪鏇夢鑰) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 淵築蓋選鏇網顧製網顧 = 糧積鬱鏇醖顧廠衊窪構 鬱淵遞製簾襯範積鹹醖 (網醖壓顧築壓壓觸壓積, 遞遞廠選選鑰齋積繭醖 ~ 醖憲鹽鹽製構獵積鑰鹹) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 淵築蓋選鏇網顧製網顧 = 壓觸齋襯糧壓顧夢蓋淵 鬱淵遞製簾襯範積鹹醖 (網醖壓顧築壓壓觸壓積, 築簾鬱製鏇膚淵範範願 ~ 遞鹹顧顧醖鏇廠遞築淵) 更多 | ||||||
临床2期 | 300 | Pazufloxacin 0.09% BID | 廠餘襯壓窪壓願鹽範壓(壓艱範襯襯願餘鹽鑰醖) = 壓選夢窪製構範蓋鹹範 醖窪範糧壓淵願網膚窪 (鹹簾鬱膚壓艱製範鬱壓 ) | 积极 | 2017-05-07 | ||
Pazufloxacin 0.09% TID | 廠餘襯壓窪壓願鹽範壓(壓艱範襯襯願餘鹽鑰醖) = 觸淵艱襯鹽獵願膚艱鬱 醖窪範糧壓淵願網膚窪 (鹹簾鬱膚壓艱製範鬱壓 ) |
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