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更新于：2025-09-03
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2025-09-03
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
10
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT02592096
A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media
100 项与 甲磺酸帕珠沙星 相关的临床结果
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100 项与 甲磺酸帕珠沙星 相关的转化医学
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100 项与 甲磺酸帕珠沙星 相关的专利（医药）
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355
项与 甲磺酸帕珠沙星 相关的文献（医药）2025-08-01SEPARATION AND PURIFICATION TECHNOLOGY
Environmentally friendly synthesis of quasi-MIL-100(Fe) with modulation defects for efficient photo-Fenton degradation of ciprofloxacin
作者: Ma, Xianyun ; Zhang, Sanbing ; Liu, Yajia ; Miao, Chang-qing ; Zhu, Bowen ; Wang, Min ; Li, Zuopeng
Defect engineering is a promising approach for constructing highly efficient catalytic activity based on metal-organic frameworks (MOFs).In this study, a defective MOFs, referred to as quasi-MIL-100(Fe), was synthesized by moderate synthesis method and then careful thermal treatment at an atm. ranging from 150 to 450°C, linking crystalline materials and the associated metal oxides.MIL-100(Fe) heat-treated at 250°C (referred to as M-250) partially breaks coordination bonds, resulting in a crystalline-to-amorphous transformation, increased porosity, and elimination of ligands.Compared to pristine MIL-100(Fe), M-250 possessed more reactive sites and exhibited the highest photo-Fenton degradation of ciprofloxacin with 95.6% removal efficiency in 90 min, despite the unfavorable photo properties for photo-Fenton performance due to the destruction of the crystal structure.Addnl., d. functional theory (DFT) calculations, combined with free radical quenching and mass spectrometry anal., elucidated the catalytic mechanism.These findings highlight the significant potential of quasi-MOFs for applications in the photo-Fenton reaction.
2025-06-01CHEMICAL ENGINEERING JOURNAL
Ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads and DNA walker for ultrasensitive quantifying enrofloxacin and ciprofloxacin
作者: Yang, Junsong ; Jiang, Hongtao ; Wang, Zhouping ; Qi, Shuo ; Dong, Xiaoze ; Ang, Beijun ; Khan, Imran Mahmood
Quinolone-antibiotic residues pose serious threat to food safety and ecol. environmental health.Therefore, we have developed a ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA (ZAFT) nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads (W/Apt-Tet-MB) and DNA walker for ultrasensitive quantification of two typical quinolone antibiotics (enrofloxacin and ciprofloxacin).Firstly, a simple and stable satellite nano assembly (Zr-MOF@AuNPs) was synthesized.DNA hairpin H1-L@FAM was coupled with Zr-MOF@AuNPs to form Zr-MOF@Au@FAM (ZAF) nano assembly.Furthermore, the W/Apt-Tet-MB demonstrated excellent capturing capability for ENR and CIP due to the efficient integration of group-specific aptamer in the DNA tetrahedra.In addition to capturing targets, the walker DNA (W) was released, triggering the opening of DNA H1 on the ZAF.Supported by fuel DNA H2 and entropy-driven mechanisms, the newly exposed ssDNA region within H1 then reacted with H2 and reporter DNA (modified with Tamra) through nucleic acid hybridization to form ZAFT and release W again.Subsequently, the released W opened other nearby H1 and continuously initiated a new round of DNA walker reaction.Thus, ZAFT was generated in large quantities.Meanwhile, significant ratiometric fluorescence signals (F585/F519) were generated and pos. correlated with the amounts of targets employing the localized surface plasmon resonance (LSPR) activities of prepared Zr-MOF@AuNPs.The developed aptasensor demonstrated good linearity in the 0.001-100 ng/mL range, with a LOD of 0.24 and 0.31 pg/mL towards ENR and CIP.Importantly, the aptasensor was successfully applied to quantify ENR/CIP in real samples with satisfactory recoveries, manifesting its prospective application in environmental monitoring and food safety.
2025-04-21JOURNAL OF DRUG TARGETING
Artificial intelligence-based molecular property prediction of photosensitising effects of drugs
Article
作者: Hofmann, Amun G. ; Agibetov, Asan ; Weber, Benedikt ; Ibbotson, Sally
Drug-induced photosensitivity is a potential adverse event of many drugs and chemicals used across a wide range of specialties in clinical medicine. In the present study, we investigated the feasibility of predicting the photosensitising effects of drugs and chemical compounds via state-of-the-art artificial intelligence-based workflows. A dataset of 2200 drugs was used to train three distinct models (logistic regression, XGBoost and a deep learning model (Chemprop)) to predict photosensitising attributes. Labels were obtained from a list of previously published photosensitisers by string matching and manual validation. External evaluation of the different models was performed using the tox21 dataset. ROC-AUC ranged between 0.8939 (Chemprop) and 0.9525 (XGBoost) during training, while in the test partition it ranged between 0.7785 (Chemprop) and 0.7927 (XGBoost). Analysis of the top 200 compounds of each model resulted in 55 overlapping molecules in the external validation set. Prediction scores in fluoroquinolones within this subset corresponded well with culprit substructures such as fluorinated aryl halides suspected of mediating photosensitising effects. All three models appeared capable of predicting photosensitising effects of chemical compounds. However, compared to the simpler model, the complex models appeared to be more confident in their predictions as exhibited by their distribution of prediction scores.
100 项与 甲磺酸帕珠沙星 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2015-07-24 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 46 | (PRO-157) | 鏇遞鬱齋積築窪網繭餘 = 窪膚簾遞簾廠顧鹽鏇遞 鬱網遞網鹹糧憲鑰蓋鏇 (鹽廠窪憲範壓觸餘衊襯, 鏇積艱簾製製蓋醖製襯 ~ 簾糧遞憲積壓築獵廠淵) 更多 | - | 2021-08-24 | ||
(Zymar) | 鏇遞鬱齋積築窪網繭餘 = 廠糧鑰遞廠衊艱醖鹹獵 鬱網遞網鹹糧憲鑰蓋鏇 (鹽廠窪憲範壓觸餘衊襯, 齋糧憲積衊觸襯鑰醖繭 ~ 積獵鑰簾積簾糧顧淵膚) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 衊憲衊觸獵憲觸遞選窪 = 觸淵網蓋遞糧鏇憲淵獵 餘觸餘襯蓋鏇膚顧遞遞 (淵網鹹製獵鏇構築網膚, 遞淵簾繭鏇網網壓醖餘 ~ 築顧糧遞鏇鹹膚餘鏇範) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 衊憲衊觸獵憲觸遞選窪 = 獵鹹憲遞構鏇顧鏇壓築 餘觸餘襯蓋鏇膚顧遞遞 (淵網鹹製獵鏇構築網膚, 獵鬱夢淵鏇糧範窪簾積 ~ 構艱獵襯簾選築構壓襯) 更多 | ||||||
临床2期 | 300 | Pazufloxacin 0.09% BID | 觸遞壓繭糧壓憲憲夢憲(鬱鹹觸窪製鹽範構餘簾) = 齋簾蓋壓構襯願觸獵餘 築壓積顧遞鑰衊築積窪 (製製鬱鏇醖鹹夢構夢襯 ) | 积极 | 2017-05-07 | ||
Pazufloxacin 0.09% TID | 觸遞壓繭糧壓憲憲夢憲(鬱鹹觸窪製鹽範構餘簾) = 糧蓋艱構觸膚製顧糧餘 築壓積顧遞鑰衊築積窪 (製製鬱鏇醖鹹夢構夢襯 ) |
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