预约演示
更新于：2026-02-26
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2026-02-26
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
10
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT02592096
A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media
100 项与 甲磺酸帕珠沙星 相关的临床结果
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100 项与 甲磺酸帕珠沙星 相关的转化医学
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100 项与 甲磺酸帕珠沙星 相关的专利（医药）
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308
项与 甲磺酸帕珠沙星 相关的文献（医药）2026-02-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Chiral separation of fluoroquinolones by capillary electrophoresis using glucosamine-functionalized carbon quantum dots as a Pseudostationary phase
Article
作者: Wu, Guoli ; Li, Chen ; Zhang, Yue ; Qu, Tingli
Fluoroquinolones are a class of widely used antibiotics, most of which contain chiral centers. Significant differences exist between their enantiomers in terms of antimicrobial activity, pharmacokinetics, and toxicity. In this study, glucosamine chiral-functionalized carbon quantum dots (GA-CQDs) were successfully synthesized and employed as a pseudostationary phase. By optimizing the chromatographic conditions, an efficient and novel chiral separation platform based on capillary electrophoresis (CE) was established for the enantioseparation of six fluoroquinolones. Compared to the CE system using free glucosamine solely as the chiral selector, the CE system employing GA-CQDs as a pseudostationary phase demonstrated a substantial improvement in chiral resolution (Rs) for all six model analytes (Ofloxacin: 1.56 → 9.21; Pazufloxacin: 0 → 8.53; Prulifloxacin: 1.38 → 7.58; Lomefloxacin: 1.01 → 2.84; Gemifloxacin: 0 → 1.25; Balofloxacin: 0 → 0.88). The incorporation of the pseudostationary phase significantly enhanced the chiral separation capability. This proposed strategy is characterized by its operational simplicity and low cost, thereby offering a valuable conceptual framework and a highly promising approach for developing chiral separation methods for fluoroquinolone antibiotics. This study represents the first report on employing GA-CQDs as a chiral selective medium to construct a capillary electrophoresis system, which achieved satisfactory enantioselectivity. Furthermore, the chiral recognition mechanism of glucosamine was preliminarily investigated through molecular modeling simulations, with the binding energy providing insights into the separation process.
2025-12-01Acta Crystallographica Section C-Structural Chemistry
Chloride salts of the antibacterial agent pazufloxacin: (H
3
O)
2
(Pzfx)
5
Cl
7
·10H
2
O and (Pzfx)Cl·1.75H
2
O·0.5C
2
H
5
OH
Article
作者: Dorovatovskii, Pavel V ; Vologzhanina, Anna V ; Tselukovskaya, Ekaterina D
Recrystallization of pazufloxacinium mesylate from HCl solutions yielded two previously unknown salts of pazufloxacin. These were characterized by X-ray diffraction and are bis(oxidanium) pentakis[(2
S
)-6-(1-azaniumylcyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0
5,13
]trideca-5(13),6,8,11-tetraene-11-carboxylic acid] heptachloride decahydrate, 2H
3
O
+
·5C
16
H
16
FN
2
O
4+
·7Cl
−
·10H
2
O (
1
), and (2
S
)-6-(1-azaniumylcyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0
5,13
]trideca-5(13),6,8,11-tetraene-11-carboxylic acid chloride ethanol hemisolvate 1.75-hydrate, C
16
H
16
FN
2
O
4+
·Cl
−
·0.5C
2
H
6
O·1.75H
2
O (
2
), which were obtained from acetonitrile and ethanol, respectively. The compounds crystallize in the noncentrosymmetric triclinic space group
P
1. Salt
1
contains five independent cations and seven chloride anions, while compound
2
contains eight independent cations and anions. In both, an intramolecular COOH...O=C hydrogen bond is present and the amino group is protonated. The cations, anions and solvent molecules form extensive hydrogen-bonded frameworks. In addition, in both structures, the cations are packed into infinite stacks
via
π–π interactions, with interplanar distances of approximately 3.2 Å.
2025-08-01SEPARATION AND PURIFICATION TECHNOLOGY
Environmentally friendly synthesis of quasi-MIL-100(Fe) with modulation defects for efficient photo-Fenton degradation of ciprofloxacin
作者: Ma, Xianyun ; Zhang, Sanbing ; Liu, Yajia ; Miao, Chang-qing ; Zhu, Bowen ; Wang, Min ; Li, Zuopeng
Defect engineering is a promising approach for constructing highly efficient catalytic activity based on metal-organic frameworks (MOFs).In this study, a defective MOFs, referred to as quasi-MIL-100(Fe), was synthesized by moderate synthesis method and then careful thermal treatment at an atm. ranging from 150 to 450°C, linking crystalline materials and the associated metal oxides.MIL-100(Fe) heat-treated at 250°C (referred to as M-250) partially breaks coordination bonds, resulting in a crystalline-to-amorphous transformation, increased porosity, and elimination of ligands.Compared to pristine MIL-100(Fe), M-250 possessed more reactive sites and exhibited the highest photo-Fenton degradation of ciprofloxacin with 95.6% removal efficiency in 90 min, despite the unfavorable photo properties for photo-Fenton performance due to the destruction of the crystal structure.Addnl., d. functional theory (DFT) calculations, combined with free radical quenching and mass spectrometry anal., elucidated the catalytic mechanism.These findings highlight the significant potential of quasi-MOFs for applications in the photo-Fenton reaction.
100 项与 甲磺酸帕珠沙星 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2015-07-24 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 46 | (PRO-157) | 窪膚蓋簾構構積廠鹽遞 = 構蓋顧網鑰觸積鑰遞鑰 鹽積獵網願獵夢鹹範積 (壓願構願廠鹽繭網構網, 糧鹹鬱鬱鹹積範窪醖餘 ~ 淵憲觸觸艱鹹網餘築簾) 更多 | - | 2021-08-24 | ||
(Zymar) | 窪膚蓋簾構構積廠鹽遞 = 膚積鬱網鏇範衊艱築選 鹽積獵網願獵夢鹹範積 (壓願構願廠鹽繭網構網, 壓淵齋襯獵構鑰襯糧顧 ~ 觸鹽製窪觸網鏇膚積築) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 餘衊膚壓窪遞願選膚衊 = 衊鏇窪鹽夢鏇鹹構蓋築 積齋淵簾構醖製糧築鏇 (網構廠衊鹽廠鏇膚簾糧, 廠繭獵襯窪遞壓衊選製 ~ 範築艱獵遞顧願顧齋鏇) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 餘衊膚壓窪遞願選膚衊 = 襯壓願衊網夢繭醖願窪 積齋淵簾構醖製糧築鏇 (網構廠衊鹽廠鏇膚簾糧, 網壓鹽鑰觸壓夢鏇鬱製 ~ 鑰範網獵構艱鬱窪觸鏇) 更多 | ||||||
临床2期 | 300 | 壓鏇鬱壓鏇遞齋壓糧簾(遞齋選醖鬱壓遞選築願) = 齋醖艱憲繭構鬱範醖觸 遞遞選網願獵製餘遞壓 (鏇獵憲觸範遞憲襯淵積 ) | 积极 | 2017-05-07 | |||
壓鏇鬱壓鏇遞齋壓糧簾(遞齋選醖鬱壓遞選築願) = 觸壓範廠蓋製廠醖衊襯 遞遞選網願獵製餘遞壓 (鏇獵憲觸範遞憲襯淵積 ) |
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