预约演示
更新于：2026-09-04
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2026-09-04
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
13
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT02592096
A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media
100 项与 甲磺酸帕珠沙星 相关的临床结果
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100 项与 甲磺酸帕珠沙星 相关的转化医学
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100 项与 甲磺酸帕珠沙星 相关的专利（医药）
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337
项与 甲磺酸帕珠沙星 相关的文献（医药）2026-02-01JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Chiral separation of fluoroquinolones by capillary electrophoresis using glucosamine-functionalized carbon quantum dots as a Pseudostationary phase
Article
作者: Wu, Guoli ; Li, Chen ; Zhang, Yue ; Qu, Tingli
Fluoroquinolones are a class of widely used antibiotics, most of which contain chiral centers. Significant differences exist between their enantiomers in terms of antimicrobial activity, pharmacokinetics, and toxicity. In this study, glucosamine chiral-functionalized carbon quantum dots (GA-CQDs) were successfully synthesized and employed as a pseudostationary phase. By optimizing the chromatographic conditions, an efficient and novel chiral separation platform based on capillary electrophoresis (CE) was established for the enantioseparation of six fluoroquinolones. Compared to the CE system using free glucosamine solely as the chiral selector, the CE system employing GA-CQDs as a pseudostationary phase demonstrated a substantial improvement in chiral resolution (Rs) for all six model analytes (Ofloxacin: 1.56 → 9.21; Pazufloxacin: 0 → 8.53; Prulifloxacin: 1.38 → 7.58; Lomefloxacin: 1.01 → 2.84; Gemifloxacin: 0 → 1.25; Balofloxacin: 0 → 0.88). The incorporation of the pseudostationary phase significantly enhanced the chiral separation capability. This proposed strategy is characterized by its operational simplicity and low cost, thereby offering a valuable conceptual framework and a highly promising approach for developing chiral separation methods for fluoroquinolone antibiotics. This study represents the first report on employing GA-CQDs as a chiral selective medium to construct a capillary electrophoresis system, which achieved satisfactory enantioselectivity. Furthermore, the chiral recognition mechanism of glucosamine was preliminarily investigated through molecular modeling simulations, with the binding energy providing insights into the separation process.
2025-12-01Acta Crystallographica Section C-Structural Chemistry
Chloride salts of the antibacterial agent pazufloxacin: (H
3
O)
2
(Pzfx)
5
Cl
7
·10H
2
O and (Pzfx)Cl·1.75H
2
O·0.5C
2
H
5
OH
Article
作者: Dorovatovskii, Pavel V ; Vologzhanina, Anna V ; Tselukovskaya, Ekaterina D
Recrystallization of pazufloxacinium mesylate from HCl solutions yielded two previously unknown salts of pazufloxacin. These were characterized by X-ray diffraction and are bis(oxidanium) pentakis[(2
S
)-6-(1-azaniumylcyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0
5,13
]trideca-5(13),6,8,11-tetraene-11-carboxylic acid] heptachloride decahydrate, 2H
3
O
+
·5C
16
H
16
FN
2
O
4+
·7Cl
−
·10H
2
O (
1
), and (2
S
)-6-(1-azaniumylcyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0
5,13
]trideca-5(13),6,8,11-tetraene-11-carboxylic acid chloride ethanol hemisolvate 1.75-hydrate, C
16
H
16
FN
2
O
4+
·Cl
−
·0.5C
2
H
6
O·1.75H
2
O (
2
), which were obtained from acetonitrile and ethanol, respectively. The compounds crystallize in the noncentrosymmetric triclinic space group
P
1. Salt
1
contains five independent cations and seven chloride anions, while compound
2
contains eight independent cations and anions. In both, an intramolecular COOH...O=C hydrogen bond is present and the amino group is protonated. The cations, anions and solvent molecules form extensive hydrogen-bonded frameworks. In addition, in both structures, the cations are packed into infinite stacks
via
π–π interactions, with interplanar distances of approximately 3.2 Å.
2025-08-01SEPARATION AND PURIFICATION TECHNOLOGY
Environmentally friendly synthesis of quasi-MIL-100(Fe) with modulation defects for efficient photo-Fenton degradation of ciprofloxacin
作者: Ma, Xianyun ; Zhang, Sanbing ; Liu, Yajia ; Miao, Chang-qing ; Zhu, Bowen ; Wang, Min ; Li, Zuopeng
Defect engineering is a promising approach for constructing highly efficient catalytic activity based on metal-organic frameworks (MOFs).In this study, a defective MOFs, referred to as quasi-MIL-100(Fe), was synthesized by moderate synthesis method and then careful thermal treatment at an atm. ranging from 150 to 450°C, linking crystalline materials and the associated metal oxides.MIL-100(Fe) heat-treated at 250°C (referred to as M-250) partially breaks coordination bonds, resulting in a crystalline-to-amorphous transformation, increased porosity, and elimination of ligands.Compared to pristine MIL-100(Fe), M-250 possessed more reactive sites and exhibited the highest photo-Fenton degradation of ciprofloxacin with 95.6% removal efficiency in 90 min, despite the unfavorable photo properties for photo-Fenton performance due to the destruction of the crystal structure.Addnl., d. functional theory (DFT) calculations, combined with free radical quenching and mass spectrometry anal., elucidated the catalytic mechanism.These findings highlight the significant potential of quasi-MOFs for applications in the photo-Fenton reaction.
100 项与 甲磺酸帕珠沙星 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2015-07-24 |
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临床结果
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适应症
分期
评价
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临床3期 | 46 | (PRO-157) | 齋艱鬱積窪憲壓願網膚 = 製糧鹹艱製顧網繭選網 醖夢鹹製選鑰獵範齋糧 (製鬱鏇選齋餘餘獵艱顧, 鏇遞夢網艱選憲顧顧夢 ~ 築醖願鏇鏇鑰憲願鏇廠) 更多 | - | 2021-08-24 | ||
(Zymar) | 齋艱鬱積窪憲壓願網膚 = 壓齋襯夢醖醖壓鑰窪衊 醖夢鹹製選鑰獵範齋糧 (製鬱鏇選齋餘餘獵艱顧, 窪襯艱壓鹽選糧積鏇繭 ~ 壓願鑰鏇衊蓋構糧壓鑰) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 遞鑰鬱鑰襯淵夢積繭廠 = 餘構衊觸艱齋簾網齋艱 積襯餘鬱廠繭遞艱鹽範 (鑰齋壓廠觸遞膚鹽製鑰, 壓夢餘獵簾蓋製膚鹽淵 ~ 膚廠鹽衊壓襯觸壓築遞) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 遞鑰鬱鑰襯淵夢積繭廠 = 積顧構淵範鏇蓋觸選襯 積襯餘鬱廠繭遞艱鹽範 (鑰齋壓廠觸遞膚鹽製鑰, 衊鏇積觸鹽餘積鹹壓繭 ~ 製壓鏇鬱廠網獵夢襯齋) 更多 | ||||||
临床2期 | 300 | 網顧範積憲顧夢壓憲鬱(淵醖鏇夢構鏇觸遞鹹艱) = 襯蓋齋艱膚構鏇繭窪廠 艱顧夢壓壓鑰鹹艱襯醖 (鬱膚醖鹽艱網顧憲窪醖 ) | 积极 | 2017-05-07 | |||
網顧範積憲顧夢壓憲鬱(淵醖鏇夢構鏇觸遞鹹艱) = 鹹簾簾艱製鑰餘繭構觸 艱顧夢壓壓鑰鹹艱襯醖 (鬱膚醖鹽艱網顧憲窪醖 ) |
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