更新于：2024-11-01

Goiter, Endemic

地方性甲状腺肿

更新于：2024-11-01

基本信息

别名

Endemic Goiter、Endemic Goiters、Endemic goiter

+ [47]

简介

A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.

关联

项与地方性甲状腺肿相关的药物

Potassium Iodide

碘化钾

靶点-

作用机制-

在研机构

ANBEX INC [+1]

原研机构

Meda Pharmaceuticals, Inc.

在研适应症

地方性甲状腺肿

非在研适应症

格雷夫斯病

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1979-11-09

项与地方性甲状腺肿相关的临床试验

CTRI/2024/02/062922 / Not yet recruiting临床2/3期IIT

Comparative Study of Analgesic Efficacy of Preoperative Bilateral Superficial Cervical Plexus Block with that of Simple Wound Infiltration with Bupivacaine Dexamethasone Mixture for Thyroidectomies - A Prospective Blinded Study - nil

开始日期2024-02-26

申办/合作机构-

CTRI/2024/01/061472 / Not yet recruiting临床4期IIT

Comparison of Pain Relief Between Dexmedetomidine and Dexamethasone as Adjuvants to Ropivacaine in Ultrasound Guided Adductor Canal Block in Unilateral Total Knee Replacement. - nil

开始日期2024-01-20

申办/合作机构-

CTRI/2019/07/020105 / Not yet recruiting临床2期

Comparison of effect of dexmedetomidine with bupivacaine versus plain bupivacaine in ultrasound guided bilateral superficial cervical plexus block for patients undergoing thyroid surgeries -a randomised double blind study

开始日期2019-07-20

申办/合作机构

Kanyakumari Government Medical College

100 项与地方性甲状腺肿相关的临床结果

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100 项与地方性甲状腺肿相关的转化医学

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0 项与地方性甲状腺肿相关的专利（医药）

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2,594

项与地方性甲状腺肿相关的文献（医药）

2024-08-01·Data in Brief

Dataset of iodine concentration in soils and grassland vegetation and radioactive contamination of pastures of the regions of the Russian Federation affected by the Chernobyl NPP accident

Article

作者: Berezkin, Victor ; Kolmykova, Liudmila ; Baranchukov, Vladimir

Iodine is a trace element with an important role in human health. Iodine deficiency is a global health problem that can provoke iodine-deficiency-related thyroid disorders, such as endemic goitre, hypothyroidism, thyroid cancer, etc. Study of iodine in the soils and vegetation was conducted from 2008 to 2022 in the Bryansk and Oryol regions of Russia. These regions are known to exhibit natural iodine deficiency and have been affected by radioactive contamination following the Chernobyl accident in 1986. Soil and grassland vegetation samples were collected from local pastures near rural settlements. The soil core was divided into layers at the following depths: 0-5 cm, 5-10 cm, 10-20 cm. The iodine content in all selected samples was determined in the GEOKHI RAS using the kinetic rhodanide-nitrite method. The information in the dataset could be used to assess the iodine deficiency in the environment of other regions situated on similar soils.

2024-05-01·Clinical Endocrinology

Use of thyroid hormones in hypothyroid and euthyroid patients: A survey of members of the Endocrine Society of Australia

Article

作者: Hegedüs, Laszlo ; Brown, Suzanne J ; Walsh, John P ; Attanasio, Roberto ; Lafontaine, Nicole ; Nagy, Endre V ; Papini, Enrico ; Perros, Petros

AbstractObjectiveHypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients.Design and ParticipantsMembers of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire.MeasurementsWe analysed questionnaires that had complete demographic data.ResultsEighty‐seven questionnaires fulfilled the criteria. LT4 was used as first line treatment for hypothyroidism by all respondents. Only 45% reported that their patients were dispensed the brand of LT4 that they recommend. LT3 (alone or in combination) was prescribed by 44% in their clinical practice. Although 49% of respondents would consider LT3 + LT4 in patients with normal TSH who had ongoing symptoms of hypothyroidism, the inability of LT4 to restore normal physiology was ranked the least likely explanation for persistent symptoms and only 32% would consider it for themselves if they were diagnosed with hypothyroidism. The majority (55%), in accordance with evidence, would not prescribe thyroid hormone to euthyroid individuals but 39% would consider use in euthyroid female infertility with high levels of thyroid antibodies and 11% in euthyroid patients with a simple goitre growing over time. LT4 use in pregnancy was variable among members.ConclusionsAustralian endocrinologists mostly follow international guidelines when prescribing thyroid hormone therapy and many prescribe combination LT3 and LT4 therapy, particularly for patients who remain symptomatic on LT4 monotherapy. Prescribing practices are largely similar to other countries who have completed similar questionnaires.

2024-04-01·Endocrinology, Diabetes & Metabolism Case Reports

Iodine deficiency hypothyroidism in children in recent years: a re-emerging issue?

Article

作者: Patel, Tejal ; Kanakatti Shankar, Roopa ; Longendyke, Rachel ; Merchant, Nadia

SummaryIodine nutrition is a growing issue within the USA due to newer trends of non-iodized salts. There are no recent reviews looking at the current state of iodine deficiency-induced hypothyroidism in children in the USA. We performed a retrospective chart review at our tertiary pediatric endocrine clinic; four met the diagnostic criteria for iodine deficiency defined by a low urine iodine level. We further characterized severity of disease, risk factors, goiter, thyroid labs and antibodies. All cases had significant goiter and were diagnosed within the last 2 years. One case had iodine deficiency due to no iodized salt intake along with concurrent diagnosis of developmental delay and multiple food allergies, while others involved the use of non-iodized salts. Two cases had iodine deficiency along with autoimmunity. It is critical to obtain a dietary history for all patients who present with goiter and/or hypothyroidism. There may be a need to consider reevaluating current preventative measures for iodine deficiency, especially for certain vulnerable populations such as children who do not consume iodized salt.Learning points

In recent decades, iodine nutrition has become a growing concern due to changing dietary patterns and food manufacturing practices.

A dietary history is crucial to obtain in children presenting with hypothyroidism and goiter, especially in children with restrictive diets due to behavioral concerns, developmental delays, or multiple food allergies.

Of the 12 different types of salts commercially available, only table salt contains iodine in an appropriate amount; thus, individuals using specialty salts can develop mild to moderate iodine deficiency-related thyroid disease.