更新于：2024-11-01

Adenocarcinoma of gallbladder with squamous metaplasia

胆囊腺癌伴鳞状化生

更新于：2024-11-01

基本信息

别名

Adenocarcinoma of Gallbladder with Squamous Metaplasia、Adenocarcinoma of the Gallbladder with Squamous Metaplasia、Gallbladder Adenocarcinoma with Squamous Metaplasia

+ [9]

简介

An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.

关联

项与胆囊腺癌伴鳞状化生相关的药物

Selumetinib sulfate

司美替尼

靶点

MEK1 x MEK2

作用机制

MEK1抑制剂 [+1]

在研机构

National Cancer Institute [+11]

原研机构

Array BioPharma, Inc.

在研适应症

神经纤维瘤病 [+53]

非在研适应症

急性早幼粒细胞白血病 [+65]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2020-04-10

MK-2206

靶点

Akt

作用机制

Akt 抑制剂

在研机构

National Cancer Institute [+1]

原研机构

Merck Sharp & Dohme Corp.

在研适应症

复发性前列腺癌 [+4]

非在研适应症

急性红细胞白血病 [+127]

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与胆囊腺癌伴鳞状化生相关的临床试验

NCT03909360 / Unknown statusN/AIIT

Role of Abdominal Drainage for Laparoscopic Cholecystectomy a Prospective Randomised Study

Surgeons usually choosing drainage tube for laparoscopic cholecystectomy according to their experiences but not guidelines. The investigators design a RCT to evaluate the role of drainage in LC surgery and compare the clinical results between drainage and no drainage.

开始日期2019-03-14

申办/合作机构

浙江大学医学院附属第二医院

NCT01859182 / Withdrawn临床2期IIT

A Multicenter Phase II Study of the Combination of AZD6244 Hydrogen Sulfate and MK-2206 in Patients With Refractory Advanced Biliary Cancers

This phase II trial studies how well selumetinib and Akt inhibitor MK-2206 work in treating patients with refractory or advanced gallbladder or bile duct cancer that cannot be removed by surgery. Selumetinib and Akt inhibitor MK-2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

开始日期2013-01-01

申办/合作机构

National Cancer Institute

NCT01093222 / Completed临床2期IIT

Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma

This phase II trial is studying how well giving sorafenib tosylate together with erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or metastatic gallbladder cancer or cholangiocarcinoma. Sorafenib tosylate and erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.

开始日期2010-04-01

申办/合作机构

National Cancer Institute

100 项与胆囊腺癌伴鳞状化生相关的临床结果

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100 项与胆囊腺癌伴鳞状化生相关的转化医学

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0 项与胆囊腺癌伴鳞状化生相关的专利（医药）

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281

项与胆囊腺癌伴鳞状化生相关的文献（医药）

2024-10-01·BMJ Case Reports

Cholecystocolonic fistula: an incidental intraoperative discovery managed laparoscopically

Article

作者: Anand, Felix ; Selvam, Pavithra ; Thariq Ajmal, Imran ; Muralidhar, Venkiteswaran

Cholecystoenteric fistula is a rare complication of cholelithiasis, occurring in 3%–5% of patients with cholelithiasis. The symptoms are typically minimal and vague, with either acute or subacute presentations, rarely leading to bowel obstruction, and occasionally manifesting as chronic abdominal pain. In this case, a male patient in his early 30s presented with epigastric and right hypochondrial pain. On evaluation, he was diagnosed with gallstone disease and adenomyomatosis of the gallbladder. During laparoscopic cholecystectomy, a cholecystocolonic fistula was unexpectedly discovered. The fistula was managed laparoscopically using ENDOLOOP (prelooped chromic catgut ligature) ligation of the fistulous tract. The patient recovered without complications and was discharged on the third postoperative day. This case emphasises the importance of intraoperative vigilance and demonstrates a successful minimally invasive management approach.

2024-09-01·Radiology Case Reports

Isolated tubercular cholecystitis: A rare diagnostic challenge

Article

作者: Kumar, Shruti ; Ahuja, Sana ; Ahluwalia, Charanjeet ; Khan, Adil Aziz

Abdominal tuberculosis, particularly affecting the hepatobiliary system, presents a diagnostic challenge due to its rarity and its tendency to mimic neoplastic conditions. Tuberculosis of the gallbladder, especially in the absence of pulmonary infection, is exceedingly rare. We present a case of isolated tubercular cholecystitis in a 41-year-old female initially suspected to have neoplastic etiology. Radiological imaging revealed thickened gallbladder wall with heterogenous enhancement extending into the subcutaneous plane. Histopathological examination post-cholecystectomy confirmed tubercular etiology with epithelioid cell granulomas and focal necrosis, alongside the presence of acid-fast bacilli. Such cases pose diagnostic dilemmas due to overlapping clinical and radiological features with gallbladder carcinoma. This report emphasizes the importance of considering tuberculosis in differentials, particularly in endemic regions like India, even without pulmonary symptoms. Treatment involves postoperative administration of anti-tubercular drugs, with the preoperative diagnosis being challenging and rarely achieved due to the avoidance of invasive procedures like fine needle aspiration in suspected carcinoma cases. The rarity of isolated gallbladder tuberculosis underscores the necessity for comprehensive diagnostic evaluations and awareness among clinicians in endemic regions.

2023-04-01·Journal of International Medical Research

Gastric schwannoma coexisting with tubular adenoma of the gallbladder: a rare combination

Article

作者: Zhou, Chang ; Chen, Xiaodi ; Peng, Yang ; Liu, Yufei ; Cai, Meng

We report a case of a man in his early 50 s who was admitted to our hospital for anorexia. An imaging examination led to a preoperative diagnosis of a gastrointestinal stromal tumor and gallbladder stones. He underwent treatment by laparoscopic cholecystectomy and distal partial gastrectomy with lymph node dissection. The final histopathological diagnosis was gastric schwannoma and tubular adenoma of the gallbladder. Gastric schwannoma accounts for only 0.2% of all gastric tumors, and tubular adenoma constitutes only 2.2% of gallbladder tumors. This report describes the diagnosis and treatment process for this combination of tumors, thus providing a reference for similar cases.