更新于：2024-11-01

twins pregnancy

双胞胎怀孕

更新于：2024-11-01

基本信息

别名

Pregnancies, Twin、Pregnancy, Twin、Pregnancy;twins

+ [17]

简介

The condition of carrying TWINS simultaneously.

关联

项与双胞胎怀孕相关的药物

Progesterone

黄体酮

靶点

作用机制

PR调节剂

在研机构

Fresenius Kabi Austria GmbH [+20]

原研机构

Mochida Pharmaceutical Co., Ltd. [+1]

在研适应症

子宫内膜增生 [+16]

非在研适应症

异常子宫出血 [+10]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1956-01-25

项与双胞胎怀孕相关的临床试验

ChiCTR2300077742 / SuspendedN/AIIT

Study on the correlation between ultrasound placental texture and fetal heart function and pregnancy outcome in monochorionic diamniotic pregnancies

开始日期2023-11-30

申办/合作机构-

ChiCTR2300077355 / SuspendedN/AIIT

Maternal and perinatal effects of hypertensive disorders during pregnancy in a cohort of multiple pregnancies

开始日期2023-11-10

申办/合作机构-

NCT05727085 / RecruitingN/AIIT

Cohort of Twin Pregnancy and the Offspring

Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.

开始日期2023-07-01

申办/合作机构

复旦大学

100 项与双胞胎怀孕相关的临床结果

登录后查看更多信息

100 项与双胞胎怀孕相关的转化医学

登录后查看更多信息

0 项与双胞胎怀孕相关的专利（医药）

登录后查看更多信息

项与双胞胎怀孕相关的文献（医药）

2024-10-01·Journal of Clinical Ultrasound

Heterotopic twin pregnancy in unicornuate uterus and non‐communicating rudimentary horn with survival of both fetuses: Magnetic resonance imaging and 3D reconstructions findings

Article

作者: Araujo Júnior, Edward ; Elito Júnior, Julio ; Castro, Pedro Teixeira ; Werner, Heron ; Sanchez, Victor Hugo Saucedo ; Goldman, Suzan Menasce

AbstractWe reported a case of heterotopic twin pregnancy in a unicornuate uterus with a non‐communicating rudimentary horn with survival of both fetuses. The diagnosis was made late at 28 weeks of gestation, with suspicion raised by ultrasound and confirmed by magnetic resonance imaging (MRI). During hospitalization, obstetric ultrasound with color Doppler was performed every 2 days to assess fetal well‐being and myometrial thickness, which was determined by measurements of the uterine wall at the accessory horn. Elective cesarean section was performed at 33 + 5 weeks of gestation. Delivery started with the fetus in the rudimentary horn, with subsequent extraction of the fetus in the unicornate uterus. Three‐dimensional virtual reconstruction allowed a spatial view of the both uterus and fetuses with better understanding of the obstetrical condition by the parents and interactive discussion by the multidisciplinary medical team.

2024-04-01·American Journal of Perinatology4区 · 医学

Ultrasonographic Diagnosis of Twin-to-Twin Transfusion Syndrome

4区 · 医学

Review

作者: Reyna-Villasmil, Eduardo ; Briceño-Sanabria, Juan C. ; Briceño-Pérez, Carlos

Introduction Twin-twin transfusion syndrome (TTTS) is a typical complication of monochorionic twin pregnancies (MCTP). Placental vessels that communicate in the chorionic plate between donor and recipient, are responsible for the imbalance of blood flow. Circulatory imbalance causes hypovolemia in donor and hypervolemia in recipient fetus. In a typical case, recipient fetus develops polyhydramnios, weight gain, cardiomegaly and hydrops fetalis. In contrast, donor fetus develops oligohydramnios and fetal growth restriction. Aim The objective of this review is to evaluate in detail the main diagnostic aspects and add other important data for diagnosis of TTTS. Scientific bases The main diagnostic event for this condition is based on the ultrasonographic discovery of oligohydramnios-polyhydramnios sequence. Other useful elements for diagnosis, staging and prognosis are fetal urinary bladder visualization, urinary bladder volumen measurements, edema of subcutaneous and/or generalized tissue edema, Doppler flow velocity waves and cardiac evaluation. Conclusion Considerations regarding diagnosis of TTTS make it possible to emphasize that role of physicians treating patients with MCTP is to identify ultrasound sequence of oligohydramnios-polyhydramnios. Other ultrasonographic fetal data as fetal urinary bladder visualization, urinary bladder volumen measurements, edema of subcutaneous and/or generalized tissue edema, Doppler flow velocity waves and cardiac evaluation; may help diagnosis, staging and prognosis of TTTS. It is their responsibility to accurately assess severity, therapeutic possibilities and prognosis. Key Points

2024-03-01·Reproductive BioMedicine Online

Pregnancy outcomes of fetal reduction in patients with intrauterine haematoma following double embryo transfer

Article

作者: Shi, Jing ; Ge, Yimeng ; Lai, Shaoyang ; Li, Rong ; Chu, Hongling ; Zhao, Jie ; Li, Xiaoxue ; Li, Xin ; Hu, Kailun

RESEARCH QUESTIONIs there an association between intrauterine haematoma (IUH) and pregnancy outcomes in patients who undergo fetal reduction after double embryo transfer (DET), and if so, what is the relationship between IUH-related characteristics and pregnancy outcomes?DESIGNClinical information and pregnancy outcomes of women who underwent fetal reduction after DET were analysed. Patients with other systematic diseases, ectopic pregnancy or heterotopic pregnancy, monochorionic twin pregnancies and incomplete data were excluded. Stratification of IUH pregnancies was undertaken based on IUH-related characteristics. The main outcome was incidence of fetal demise (<24 weeks), with other adverse pregnancy outcomes considered as secondary outcomes.RESULTSThirty-four IUH patients and 136 non-IUH patients who underwent fetal reduction after DET were included based on a 1:4 match for age, cycle type and fertilization method. IUH patients had a higher incidence of early fetal demise (20.6% versus 7.4%, P = 0.048), threatened abortion (48.1% versus 10.3%, P<0.001) and postpartum haemorrhage (PPH; 14.8% versus 4.0%, P = 0.043) compared with non-IUH patients. IUH was an independent risk factor for early fetal demise [adjusted OR (aOR) 3.34, 95% CI 1.14-9.77] and threatened abortion (aOR 8.61, 95% CI 3.28-22.61) after adjusting for potential confounders. IUH pregnancies undergoing fetal reduction that resulted in miscarriage had larger IUH volumes and earlier diagnosis (both P < 0.03). However, IUH characteristics (i.e. volume, changing pattern, presence or absence of cardiac activity) were not associated with threatened abortion or PPH.CONCLUSIONSFetal reduction should be performed with caution in IUH pregnancies after DET as the risk of fetal demise is relatively high. Particular attention should be given to IUH patients with early signs of threatened abortion and inevitable fetal demise.