Morton s neuroma is an irritation of the nerves that affect the feet. People with this condition may have burning or shooting pain in the balls of their feet. They may also have numbness in adjacent areas. These symptoms may become more frequent and severe over time. The pain may become permanent. Current treatments tend to be short-lived, and they do not work in all people. Better treatments are needed.
Objective:
To test a study drug, resiniferatoxin (RTX), in people with Morton s neuroma.
Eligibility:
Healthy people aged 18 and older who have Morton s neuroma and have tried other standard treatments that did not ease their pain.
Design:
Participants will be involved in the study up to 4 months.
They will be screened. They will have a physical exam with blood tests. They will have a test of their heart function. They will have X-rays of their affected feet. They will have tests to assess their pain and how their feet react to touch and changes in temperature. They will complete questionnaires about their pain.
RTX is injected into the foot at the site of the nerve pain. Participants will receive a shot to numb the area before the RTX is administered. They will be monitored in the clinic for 4 hours after they receive the RTX.
Participants will receive up to 5 follow-up phone calls per week. Each call will take 5 to 10 minutes. They will be asked about their foot pain and whether they have had any side effects from the RTX.
Participants will return to the clinic 4 weeks after the treatment. Previous tests will be repeated.

开始日期2024-11-04

申办/合作机构

National Institutes of Health Clinical Center

TCTR20240724001 / Recruiting临床2/3期IIT

Simple Neurectomy Versus Neurectomy with Intramuscular Implantation for Interdigital Neuroma: A randomized controlled trial

开始日期2023-07-01

申办/合作机构

Phramongkutklao Hospital

NCT05625282 / RecruitingN/AIIT

Plantar Plate Repair for Treatment of Floating Toe: Must we Associate it to Weil Osteotomy?

The aim of this study is to assess if isolated Weil osteotomy for floating toe grade II or III provides results that are not inferior to those obtained with the Weil osteotomy associated with plantar plate repair.

开始日期2022-11-18

申办/合作机构-

100 项与莫顿神经瘤相关的临床结果

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100 项与莫顿神经瘤相关的转化医学

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0 项与莫顿神经瘤相关的专利（医药）

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823

项与莫顿神经瘤相关的文献（医药）

2024-10-01·The Bone & Joint Journal

a randomized controlled trial

Article

作者: Arliani, Gustavo G. ; Ferreira, Gabriel F. ; Ray, Robbie ; Patriarcha, Vitor A. ; Fernandes, Tifani D. ; Lewis, Thomas L. ; Filho, Miguel V. ; Pedroso, João P.

AimsA local injection may be used as an early option in the treatment of Morton’s neuroma, and can be performed using various medications. The aim of this study was to compare the effects of injections of hyaluronic acid compared with corticosteroid in the treatment of this condition.MethodsA total of 91 patients were assessed for this trial, of whom 45 were subsequently included and randomized into two groups. One patient was lost to follow-up, leaving 22 patients (24 feet) in each group. The patients in the hyaluronic acid group were treated with three ultrasound-guided injections (one per week) of hyaluronic acid (Osteonil Plus). Those in the corticosteroid group were treated with three ultrasound-guided injections (also one per week) of triamcinolone (Triancil). The patients were evaluated before treatment and at one, three, six, and 12 months after treatment. The primary outcome measure was the visual analogue scale for pain (VAS). Secondary outcome measures included the American Orthopaedic Foot and Ankle Society (AOFAS) score, and complications.ResultsBoth groups showed significant improvement in VAS and AOFAS scores (p < 0.05) after 12 months. The corticosteroid group had a significantly greater reduction in VAS and increase in AOFAS scores compared with the hyaluronic acid group, at one, three, and six months, but with no significant difference at 12 months. There were no complications in the hyaluronic acid group. There were minor local complications in six patients (six feet) (25.0%) in the corticosteroid group, all with discolouration of the skin at the site of the injection. These minor complications might have been due to the three weekly injections of a relatively high dose of corticosteroid. No patient subsequently underwent excision of the neuroma.ConclusionAn ultrasound-guided corticosteroid injection showed statistically significantly better functional and pain outcomes than an ultrasound-guided injection of hyaluronic acid for the treatment of a Morton’s neuroma at many timepoints. Thus, a corticosteroid injection should be regarded as a primary option in the treatment of these patients, and the only indication for an injection of hyaluronic acid might be in patients in whom corticosteroid is contraindicated.Cite this article: Bone Joint J 2024;106-B(10):1093–1099.

2024-09-25·Journal of Perinatal Medicine

Common foot and ankle disorders in pregnancy: the role of diagnostic ultrasound

Review

作者: Sahr, Meghan E. ; Positano, Rock G. ; Chervenak, Frank A. ; Positano, Rock C. ; Nwawka, Ogonna K. ; Grünebaum, Amos

AbstractFoot and ankle disorders are common during pregnancy, driven by significant physiological changes including weight distribution, hormonal fluctuations, and fluid balance. These changes often result in conditions such as varicose veins, thrombophlebitis, deep vein thrombosis (DVT), edema, overpronation, ankle sprains, metatarsalgia, stress fractures, ligament tears, synovitis, tendon tears, tenosynovitis, paratenonitis, plantar fasciitis, and Morton’s neuroma. This paper emphasizes the diagnostic utility of ultrasound for these conditions, given its safety, non-invasiveness, and real-time imaging capabilities without ionizing radiation. Ultrasound is particularly effective for diagnosing venous disorders like varicose veins and thrombophlebitis, leveraging Doppler ultrasound to assess vein structure and function. It is also instrumental in identifying DVT, detecting vein dilation, reflux, and thrombosis. For conditions such as edema, ultrasound helps differentiate physiological from pathological causes, ensuring accurate diagnosis and management. In cases of musculoskeletal issues like overpronation, ankle sprains, ligament tears, and tendon pathologies, ultrasound provides detailed images of soft tissues, allowing for precise diagnosis and effective treatment planning. It is equally useful for detecting metatarsalgia, plantar fasciitis, and Morton’s neuroma, offering insights into soft tissue abnormalities and guiding therapeutic interventions. Ultrasound’s role extends to diagnosing foreign bodies in the foot and ankle, where it demonstrates high sensitivity and specificity. The accessibility and cost-effectiveness of ultrasound make it an invaluable tool in various healthcare settings, ensuring timely and accurate diagnosis and management of foot and ankle disorders during pregnancy, ultimately enhancing patient outcomes and quality of life.

2024-09-05·Cureus

Morton’s Foot Syndrome: A Case Report and Overview

Article

作者: Kizhakkemuriyil Scaria, Tony ; Sundaramurthi, Indumathi ; Sivaji, Akshaya Rathin

Morton's foot syndrome is a hereditary condition characterized by a short first metatarsal compared to the second metatarsal. It often remains asymptomatic but can present with secondary complications. We report a case of a 46-year-old female presenting with Morton's foot syndrome, initially admitted for fatigue and weakness. Physical examination revealed characteristic foot deformities and multiple plantar calluses. This case highlights the anatomical features, pathophysiology, and biomechanical implications of Morton's foot syndrome. We discuss the challenges in differentiating between normal foot structure and Morton's foot, along with potential complications and strategies for effective management. This case report enhances understanding of Morton's foot syndrome, emphasizing the importance of recognizing this condition in clinical practice to prevent potential complications and provide appropriate management.