更新于：2024-11-01

Dens in Dente

牙中牙

更新于：2024-11-01

基本信息

别名

Dens in Dente、Dens in Dentes、Dens in dente

+ [21]

简介

Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.

关联

项与牙中牙相关的药物

Hydronidone

羟尼酮

靶点

TGF-β

作用机制

TGF-β抑制剂 [+1]

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期1800-01-20

项与牙中牙相关的临床试验

NCT05414019 / Enrolling by invitationN/AIIT

Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics : A Randomized Clinical Trial

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

开始日期2024-03-15

申办/合作机构

Al-Azhar University

NCT04139174 / Unknown statusN/AIIT

Assessment of Root Parallelism Following Orthodontic Treatment in Adolescent vs Adult Patients Treated With Maxillary First Premolar Extraction: Observational -Analytical Study

Panoramic radiographs of finished orthodontic cases will be collected after fulfilling the inclusion and exclusion criteria. Then the collected data will be divided into two groups according to age either adolescent (12-18 years old) or adult group (after 18 years old).
in the panoramic views the long axes of canines and second premolar will be traced digitally using Digital softwares (microDicom vierwer Simeo Antonov Stoykov 0.7.7) & (IC Measure 2.0.0.161).
The objective of this study is to assess the root parallelism between maxillary canines and second premolars in adolescents versus adults group of patients requiring maxillary first premolar extraction during the orthodontic treatment.

开始日期2019-11-01

申办/合作机构

Cairo University

NCT04162821 / Completed临床1期

Clinical Pharmacokinetics of Hydroxynitone Capsules in Healthy Chinese Subjects

To evaluate the pharmacokinetic characteristics of hydronidone capsules (specification: 30 mg/ pill) in healthy subjects And the effect of feeding on pharmacokinetics to provide evidence for phase II/III clinical trial protocols.

开始日期2019-10-30

申办/合作机构

北京康蒂尼药业股份有限公司

100 项与牙中牙相关的临床结果

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100 项与牙中牙相关的转化医学

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0 项与牙中牙相关的专利（医药）

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345

项与牙中牙相关的文献（医药）

2024-10-01·Oral Radiology

Correction: Radiologic evaluation of associated symptoms and fractal analysis of unilateral dens invaginatus cases

作者: Koc, Alaettin ; Kaya, Sema

2024-10-01·Journal of Endodontics

Dens invaginatus Type II in an Immature Lateral Incisor With Apical Periodontitis Treated With Regenerative and Strategic Antimicrobial Procedures: A Case Report

Article

作者: Martin, Gabriela ; Siqueira, José F ; Cires, Florencia ; Alberdi, Jorge ; Bonnin, Claudia ; Rourera, Cecilia I ; Rôças, Isabela N

Dens invaginatus is a developmental dental anomaly that can predispose the tooth to pulp and periradicular disease. Management of this condition can be challenging because of anatomic and microbiologic issues. This case report describes the regenerative endodontic treatment using a strategic antimicrobial protocol for management of an immature maxillary lateral incisor with type-II dens invaginatus associated with apical periodontitis in a 13-year-old patient. The tooth presented with a complex anatomy and was associated with an active sinus tract. Because the true root canal was not negotiable in its coronal part due to the presence of the dens invaginatus, the closed end of the invagination (pseudocanal) was perforated to permit access to the apical segment of the true root canal for cleaning and disinfection. Both the invagination and the true canal were treated using an antimicrobial regimen based on chemomechanical preparation with sodium hypochlorite irrigation, supplementary disinfection with passive ultrasonic irrigation and interappointment calcium hydroxide medication. After 2 exchanges of calcium hydroxide medication, the sinus tract did not disappear, then the antimicrobial protocol was changed to include an antibiotic solution for irrigation and antibiotic paste for intracanal medication. After signs and symptoms disappeared, regenerative endodontic treatment was performed by inducing blood clot formation within the root canal. The coronal canal segment including the invagination was filled with Biodentine. Follow-up including cone-beam computed tomography examination showed complete healing of the apical periodontitis lesion and mineralized tissue formation at the apical portion of the true root canal.

2024-10-01·Oral Radiology

Radiologic evaluation of associated symptoms and fractal analysis of unilateral dens invaginatus cases

Article

作者: Koc, Alaettin ; Kaya, Sema

OBJECTIVEThe aim of this study is to determine the age-based prevalence of dens invaginatus cases and to learn the radiologic findings. In addition, fractal analysis of the periapical regions of unilateral dens invaginatus cases and contralateral teeth was performed to determine the effect of possible microleakage on fractal dimension.METHODSA total of 136 patients (170 teeth) identified in panoramic radiographs taken for diagnostic purposes between January 2018 and December 2023 at our Department of Oral and Maxillofacial Radiology were included in the study. Data were analysed using IBM SPSS V23. The Chi-square test was used for comparing categorical variables between groups. The relationship between the FD values calculated around the apexes of the teeth with unilateral dens invaginatus and the contralateral teeth was analyzed by paired t test. A significance level of p < 0.050 was adopted.RESULTSThe mean age of the cases was calculated as 28.1 (8-63) years. 66 (48.5%) of the cases were female, and 70 (51.1%) were male. The lateral incisor was the most affected tooth among these cases. Bilateral cases were observed in 34 patients. Type 2 was detected in 93 patients, Type 1 in 35 patients, and Type 3 dens invagination in 8 patients. Dens invaginatus cases were observed in 134 maxillary and 2 mandibular teeth. Periapical lesions were seen in 22 of these cases.CONCLUSIONSDens invaginatus cases are a congenital anomaly encountered at any age. Early diagnosis is crucial to prevent the loss of pulp vitality due to these invaginations. It should be noted that these invaginations can affect both jaws. However, due to the prevalence of occurrence in the maxillary anterior teeth and asymptomatic nonvitality, particular attention should be paid to evaluating this region.