Maple Syrup Urine Disease

Acer Shareholders – Please Vote Today!NEWTON, Mass., Nov. 02, 2023 (GLOBE NEWSWIRE) -- Acer Therapeutics Inc. (Nasdaq: ACER), a pharmaceutical company focused on the acquisition, development and commercialization of therapies for serious, rare and life-threatening diseases with significant unmet medical needs, today announced that Institutional Shareholder Services Inc. (ISS) and Glass, Lewis & Co. LLC (Glass Lewis) recommended that Acer shareholders vote "FOR" the proposed merger with Zevra Therapeutics, Inc. and the related proposals in the Company's proxy statement and prospectus for the special meeting of its shareholders to be held on November 8, 2023 at 11:00 a.m. Eastern Time. ISS and Glass Lewis are widely recognized as the leading independent voting and corporate governance advisory firms. Their analysis and recommendations are relied on by many major institutional investment firms, mutual funds and fiduciaries throughout North America. In its report, ISS stated, among other things, that “The transaction warrants support in light of the reasonably thorough review of alternatives, the positive market reaction, the upside potential provided by the stock and CVR forms of consideration, and the downside risk of non-approval.” Glass Lewis concluded that the transaction would allow Acer shareholders to participate in a larger and better capitalized pharmaceutical company, while also retaining significant upside potential through the CVR consideration, at a time when Acer appears to have few, if any, viable alternatives. Glass Lewis also noted that the total implied value of the proposed consideration represents a substantial premium to the unaffected trading price of Acer shares and the merger consideration compares favorably with the expected outcome in a liquidation scenario, in which Acer shareholders were not expected to receive any proceeds. Commenting on the proxy advisors’ reports, Chris Schelling, CEO and Founder of Acer, said: "The ISS and Glass Lewis recommendations are consistent with our view that the merger with Zevra is in the best interest of Acer shareholders." The merger and related agreements have been unanimously approved by the boards of directors of both companies. The merger and related proposals have been unanimously approved by Acer’s board of directors. Failure to vote or an abstention from voting will have the same effect as a vote "AGAINST" the merger proposal. All shareholders are asked to vote "FOR" all proposals as soon as possible. THE MERGER WILL NOT GO FORWARD UNLESS THE MERGER AND RELATED PROPOSALS ARE APPROVED. ACER SHAREHOLDERS – PLEASE VOTE TODAY! If the merger is not approved on November 8, ACER will begin trading on OTC Pink Market starting on November 9 because of the failure by the Company to regain compliance, during the previously granted 180 calendar day grace period, with Nasdaq’s requirement of having at least $35 million in market value of listed securities, resulting in the trading suspension of ACER on Nasdaq. If the merger is not subsequently consummated, Acer will not be able to fund its business operations and will likely be forced to terminate operations, liquidate or file for bankruptcy. If you are an Acer shareholder and you have questions or require assistance in submitting your proxy or voting your shares, please contact Acer’s proxy solicitor: ADVANTAGE PROXY, INC.Toll Free: 1-877-870-8565Collect: 1-206-870-8565Email: ksmith@advantageproxy.com Additional Information about the Proposed Merger between Acer and Zevra, the Special Meeting and Where to Find ItIn connection with the proposed merger, Zevra has filed a registration statement on Form S-4 with the Securities and Exchange Commission (the "SEC"), including a proxy statement / prospectus. The registration statement was declared effective on October 10, 2023. Additionally, Acer’s proxy statement was filed on October 10, 2023. Acer shareholders are urged to read these materials because they contain important information about Acer, Zevra and the proposed merger. The proxy statement / prospectus and other relevant materials, and any other documents filed by Zevra and Acer with the SEC, may be obtained free of charge at the SEC website at www.sec.gov. In addition, Acer shareholders will be able to attend the Acer special meeting via the Internet at https://www.cstproxy.com/acertx/sm2023 and view the Acer 2023 Special Meeting Proxy Statement and the Zevra Therapeutics, Inc. Forms 10-K, 10-Qs and 8-Ks. Acer shareholders are urged to read the proxy statement / prospectus and the other relevant materials before making any voting or investment decision with respect to the proposed merger. No Offer or SolicitationThis communication is for informational purposes only and not intended to and does not constitute an offer to subscribe for, buy or sell, the solicitation of an offer to subscribe for, buy or sell or an invitation to subscribe for, buy or sell any securities or the solicitation of any vote or approval in any jurisdiction pursuant to or in connection with the proposed transaction or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended (the “Securities Act”), and otherwise in accordance with applicable law. Participants in the SolicitationAcer, Zevra and their respective directors and executive officers may be considered participants in the solicitation of proxies in connection with the proposed transaction. Information about the directors and executive officers of Acer is set forth in its Annual Report on Form 10-K for the year ended December 31, 2022, which was filed with the SEC on March 27, 2023, and its proxy statement for its 2023 annual meeting of shareholders, which was filed with the SEC on April 14, 2023. Information about the directors and executive officers of Zevra is set forth in its Annual Report on Form 10-K for the year ended December 31, 2022, which was filed with the SEC on March 7, 2023, and its proxy statement for its 2023 annual meeting of stockholders, which was filed with the SEC on March 15, 2023, the definitive proxy statement filed by Daniel J. Mangless, together with the other participants named therein, which was filed with the SEC on March 17, 2023, and Zevra’s Current Reports on Form 8-K, filed with the SEC on March 30, 2023, May 8, 2023, May 15, 2023, and August 7, 2023. Other information regarding the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, is set forth in the proxy statement/prospectus and other relevant materials filed with the SEC and may be obtained free of charge from the sources indicated above. About Acer TherapeuticsAcer is a pharmaceutical company focused on the acquisition, development and commercialization of therapies for serious rare and life-threatening diseases with significant unmet medical needs. In the U.S., OLPRUVA® (sodium phenylbutyrate) is approved for the treatment of UCDs involving deficiencies of CPS, OTC, or AS. Acer is also advancing a pipeline of investigational product candidates for rare and life-threatening diseases, including: OLPRUVA® (sodium phenylbutyrate) for treatment of various disorders, including Maple Syrup Urine Disease (MSUD); and EDSIVO™ (celiprolol) for treatment of vascular Ehlers-Danlos syndrome (vEDS) in patients with a confirmed type III collagen (COL3A1) mutation. For more information, visit www.acertx.com. Forward-Looking StatementsDISCLOSURE NOTICE: This press release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended, related to Acer, Zevra and the proposed acquisition of Acer by Zevra. All statements other than statements of historical fact are forward-looking statements for purposes of federal and state securities laws. These forward-looking statements involve uncertainties that could significantly affect the financial or operating results of Acer, Zevra or the combined company. These forward-looking statements may be identified by terms such as anticipate, believe, foresee, expect, intend, plan, may, will, could, should and would and the negative of these terms or other similar expressions. Forward-looking statements in this document include, among other things, statements about the potential benefits of the proposed acquisition; statements about contingent cash consideration and related milestones as contemplated by the CVR Agreement; the anticipated timing of closing of the acquisition; the delisting of Acer’s stock from Nasdaq and resulting move to OTC Pink Market; and that, if the merger is not subsequently consummated, Acer will not be able to fund its business operations and will likely be forced to terminate operations, liquidate or file for bankruptcy. These forward-looking statements involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, risks related to the satisfaction of the conditions to closing the acquisition (including the failure to obtain necessary stockholder approval) in the anticipated timeframe or at all; risks related to the ability to realize the anticipated benefits of the acquisition, including the possibility that the expected benefits from the proposed acquisition will not be realized or will not be realized within the expected time period; risks related to the contingent cash consideration and related milestones as contemplated by the CVR Agreement, including that such milestone may not be achieved and thus the related cash consideration would not become payable; the risk that the businesses will not be integrated successfully; disruption from the transaction making it more difficult to maintain business, contractual and operational relationships; the unfavorable outcome of the legal proceedings that have been or may be instituted against Acer, Zevra or the combined company; the ability to retain key personnel; negative effects of this announcement or the consummation of the proposed acquisition on the market price of the capital stock of Acer and Zevra and on Acer’s and Zevra’s operating results; risks relating to the value of Zevra’s shares to be issued in the transaction; significant transaction costs, fees, expenses and charges; unknown liabilities; the risk of litigation and/or regulatory actions related to the proposed acquisition; the financing of the transaction and Acer’s interim operations; the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement; other business effects, including the effects of industry, market, economic, political or regulatory conditions; future exchange and interest rates; changes in tax and other laws, regulations, rates and policies; future business combinations or disposals; and competitive developments. A further description of risks and uncertainties relating to Acer and Zevra can be found in their respective most recent Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, all of which are filed with the SEC and available at www.sec.gov. Neither Acer nor Zevra intends to update the forward-looking statements contained in this document as the result of new information or future events or developments, except as required by law. Corporate ContactHarry PalminChief Financial OfficerAcer Therapeutics Inc.investors@acertx.com+1-844-902-6100

3D打印技术（three-dimensional printing，3DP）是基于计算机构建的数字模型，通过“分层打印，逐层叠加”的方式生产制造三维实体。凭借数字化和个性化的制造方式，近年来3D打印技术在制药领域的应用备受行业关注。作为一种前沿技术，3D打印将为医药行业带来全新的药物开发范式和生产模式。那么，3D打印技术的发展历程如何？目前有哪些药企入局？又面临着什么样的问题和挑战？PART.013D打印技术的发展史3D打印的理念最早起源于19世纪末美国的照相雕塑和地貌成形技术。不过直到上世纪80年代末才有了雏形。1986年，美国人Charles Hull应用立体光固化成型技术（SLA）发明了第一台3D打印机。1996年，MIT（麻省理工）的Michael J. Cima教授首次报道了粉末粘结3D打印技术可应用于制药领域。同年，全球第一家药物3D打印公司Therics在美国成立，药物3D打印行业由此起步。与传统制造技术相比，3D打印能够减少复杂的工艺流程，以较高的生产效率制造出具有特殊外型或复杂内部结构的物体。 在经过了漫长的技术验证期后，2015年7月，FDA批准了第一款3D打印药物Spritam（左乙拉西坦），用于癫痫病的治疗，该药物由美国Aprecia公司开发，使用药物粉末粘结技术获得。它的批准标志着3D打印制药技术获得监管部门认可，激起了又一轮行业研发热潮。在技术分类上，按照美国材料与试验协会（ASTM）F42增材制造技术委员会的分类标准，3D打印技术可分为7类：材料挤出成型技术、粘合剂喷射成型技术、粉末床熔融成型技术、光聚合固化技术、材料喷射成型技术、直接能量沉积技术和薄膜层积技术。其中，材料挤出成型技术、粘合剂喷射成型技术、粉末床熔融成型技术和光聚合固化技术这4大类3D打印技术，被应用于制药领域。PART.02国内外重点布局企业目前，国内外已有数十家企业参与3D打印制药技术的探索和开发，并形成了各自不同的技术路线。NO.1ApreciaAprecia成立于2003年，其目标是把先进的3D打印药物技术应用到药物产品开发中，并实现商业化生产。2007年，Aprecia根据MIT的粉末粘结3D打印技术开发出了ZipDose制药技术的雏形。ZipDose技术不仅解决了患者吞咽困难的问题，还解决了普通口服固体制剂载药量低的技术壁垒，还具有良好的掩味作用，对掩味困难的原料药同样有效。而且该技术平台具有广泛的适用性，适用于大分子和小分子药物。同时，Aprecia开发出了规模化满足GMP要求的药物生产系统。2015年，Aprecia的抗癫痫药物Spritam获FDA批准上市，其应用3D打印技术，具有内部多孔的结构，可实现迅速崩解，解决吞咽困难的临床需求。不过由于活性药物成分左乙拉西坦的商业竞品较多，Spritam上市后业绩平平。除了生产自己的药品之外，Aprecia还许可其他公司来使用技术平台，扩大业务范围。NO.2三迭纪南京三迭纪医药科技有限公司（简称“三迭纪”，英文名Triastek）成立于2015年7月，其目标是建设全新的药物3D打印技术平台。三迭纪首创的热熔挤出沉积（MED）技术，是一条不同于其他公司的药物3D打印技术路线。该技术在药片生产时，可直接将粉末状的原辅料混匀熔融成可流动的半固体，再以高精度挤出，打印成型，适用于具有复杂内部三维结构药物制剂的生产制造。三迭纪基于剂型源于设计的理念，对药物制剂内部采用独特的三维结构设计，可精确实现药物释放时间、部位、速率及释放方式的程序化控制，为需要高难度制剂技术的新分子药物产品开发提供了解决方案。另外，三迭纪的MED技术还可实现原料药和辅料粉末的混合、熔融和输送，为连续化进料和打印提供底层技术支持，可实现高效、高通量的规模化生产。基于MED技术平台，三迭纪开发了涉及结肠靶向、增溶、胃滞留和口服多肽等热门领域的药物递送技术，颠覆了传统固体制剂的开发和生产方式以及药物传递方式，年产能达到5000万片。目前，三迭纪通过505(b)(2)途径，已有两款药物获得FDA的IND批准。产品之一T19于2021年1月获FDA临床研究许可，该产品根据时辰治疗学原理，针对类风湿性关节炎症状的昼夜节律进行设计。患者睡前服用T19，血液中的药物浓度在疾病症状最严重的早晨到达峰值，并维持日间血药浓度，从而取得最佳的药物治疗效果。另一款产品T20于2022年3月获得FDA临床研究许可，其原研产品是全球最畅销的一款抗凝血药物，化合物在美国、欧洲、日本等主要市场国家和地区仍在专利保护期，其年销售峰值预估高达220亿美元。不过原研产品为速释片，需要一天服用两次。T20产品被分为多个腔室，可根据活性成分在胃、肠不同段的吸收率分配各腔室剂量和释放时间，实现一次给药即能达到原来两次给药相似效果的目的，可以一天一次给药，提高了患者的依从性。另外，三迭纪的第三款3D打印药物T21已于今年7月份完成全球首次人体试验，其原研药物是口服Janus激酶（JAK）抑制剂托法替布。T21于2022年11月获FDA临床研究许可，在今年第一季度启动了首次人体试验，研究结果证实T21被精准递送至目标部位结肠，达到试验预期。T21是一款中重度溃疡性结肠炎（UC）治疗药物，设计目标是将药物直接递送至结肠病灶部位发挥作用，从而大幅降低用药剂量及全身暴露引起的副作用。目前，三迭纪已就3D打印药物专有设备及3D打印数字化药物开发方法提交了156项专利申请，成为全球3D打印药物领域专利布局最完整的机构。NO.3FabRxFabRx由伦敦大学的研究人员在2014年创建。针对个性化给药，FabRx开发了3D打印机M3DIMAKER和软件M3DISEEN，并于2019年在西班牙一家医院进行了儿童临床试验，为患有罕见的代谢紊乱——枫糖尿病（MSUD）的儿童制备了个性化药物剂型。临床试验结果显示，其产品能更好地控制患者体内亮氨酸、异亮氨酸和缬氨酸的血液水平，且味道和颜色患者接受度高。FabRx还开发了直接粉末挤出技术，可快速灵活地制备多种药物剂型，更好地应用于个性化制药场景。NO.4Merck KGaA（德国默克）Merck KGaA（德国默克）于2020年2月宣布，计划使用粉末床熔融3D打印技术开发和生产药物用于临床试验，并与全球最大的3D打印设备制造商德国EOS旗下的AMCM签订了合作协议，开发规模化药用3D打印设备用于商业化生产。2022年，Merck KGaA与三迭纪共同在美国医药媒体Pharma's Almanac上发表了一篇文章，文章首次披露了双方合作契机和合作研究成果，通过MED技术和Merck辅料相结合，成功实现了难溶药物的增溶，并为提高体内生物利用度这一难题提供了技术解决方案。NO.5TNO荷兰应用科学研究组织TNO于1932年成立，其在多材料复合打印和高速打印方向上有着深厚的技术积累。近年来TNO开始进军3D打印食品和药物领域，在药物上的研究方向主要集中于个性化制药，以及利用3D打印加速药物产品早期开发上。NO.6阿斯利康2019年，阿斯利康宣布和全球工业喷墨技术领先者英国赛尔公司（Xaar）以及3D打印设备公司Added Scientific进行合作，探索通过喷墨3D打印技术进行临床个性化用药的工业化生产的可行性。PART.03各项利好政策落地3D药物打印仍面临挑战与传统药物制备工艺相比，3D打印技术具有极高的可控性和灵活性，非常适合个性化制剂及创新型制剂的制造，从而更好地解决复杂给药方案和特定患者人群的给药问题。因此，药物3D打印技术越来越受到重视，政策也一直在助力行业的发展。2017年，FDA发布促进新兴技术用于制药的行业指南，其中3D打印和连续化生产是重要的战略方向；还将3D打印药物定义为制药的新兴技术，对于3D打印药物的审评也保持着开放与欢迎的积极态度；中国CDE对于3D打印在制药行业的应用表示认可与关注。2019年，CDE专家曾发文展望3D打印技术的应用前景及挑战，并有意愿积极推进3D打印在制药行业的应用。2021年，CDE发布关于公开征求ICH指导原则《Q13：原料药和制剂的连续制造》意见的通知，药物3D打印连续化生产技术与此法规息息相关。不过，药物3D打印技术的开发和产业化仍面临较大挑战。在技术开发方面，需对制药工艺和药物剂型设计进行辅料研究，对药物三维结构新剂型的释放机制进行体内外研究和验证。需要弄清3D打印设计中，影响药物释放速率和机制的关键因素是什么；如何评估3D打印药品的性能，是否可以使用传统的体外测试方法来评价3D打印药品；如何界定每种3D打印技术的关键工艺参数等。在技术应用方面，对于药物3D打印公司，需走通国家的法规路径，以保障产品未来实现商业化。目前，数字化、智能化转型是生物医药产业高质量发展的必经之路。作为产业的重要一环，制药产业的智能化发展不可或缺，3D打印药物技术被行业誉为新的“奇点”，是制药技术的底层革命，它为制药产业的智能化发展提供了一种关键的解题思路。总的来说，全球3D打印药物行业尚处于萌芽期，3D打印药物的前景明朗，但其产业化进程依旧道阻且长。身处其中的行业参与者们如何享受到这波技术浪潮带来的时代红利，笔者认为如何实现技术商业化是回答这个问题的核心。参考资料：1.《药物3D打印行业报告》，沙利文.2.Ameeduzzafar, Alruwaili NK, Rizwanullah M, Abbas Bukhari SN, Amir M, Ahmed MM, Fazil M. 3D Printing Technology in Design of Pharmaceutical Products. Curr Pharm Des. 2018;24(42):5009-5018.3.王雪,张灿,平其能.3D打印技术在药物高端制剂中的研究进展[J].中国药科大学学报,2016,47(02):140-147.4.Sen K, Mehta T, Sansare S, et al. Pharmaceutical applications of Powder-based Binder Jet 3D printing process- A Review[J]. Advanced Drug Delivery Reviews, 2021, 177.5.http://www.3ders.org/articles/20171003-ing-says-3d-printing-could-account-for-half-of-manufactured-goods-by-2060-wiping-out-25-percent-of-global-trade.html.专栏作者小时光生化与分子生物学背景，曾从事食管鳞癌的分子分型工作，熟悉各实体瘤的发病机制和用药方案。现以发现和传播知识为谋生手段，学无止境，希望自己永远保持谦虚的心态和可塑性，和各位同道一起迎接医药领域的黄金时代。*声明：本文仅是介绍医药疾病领域研究进展或简述研究概况或分享医药相关讯息，并非也不会进行治疗或诊断方案推荐，也不对相关投资构成任何建议。内容如有疏漏，欢迎沟通指出！

Acer Therapeutics buys Relief Therapeutics' stake in OLPRUVA™ worldwide, excluding geographical Europe, providing an upfront payment of $10 million in cash to Relief Therapeutics with the potential for an additional $46.5 million in milestone and royalty payments The transition from a profit-based to a revenue-based royalty stream model is expected to deliver earlier returns and enhanced predictability to Relief Therapeutics GENEVA, SWITZERLAND / ACCESSWIRE / August 30, 2023 / RELIEF THERAPEUTICS Holding SA (SWX:RLF), (OTCQB:RLFTF, RLFTY) (Relief Therapeutics), a biopharmaceutical company committed to delivering innovative treatment options for select specialty, unmet and rare diseases, today announced it has entered into a new exclusive definitive licensing agreement with Acer Therapeutics Inc. (Acer Therapeutics) for the development and commercialization of OLPRUVA™ (sodium phenylbutyrate, ACER-001) for the treatment of certain urea cycle disorders (UCDs) and other potential indications. This agreement supersedes the March 2021 collaboration and license agreement between the companies, which has been cancelled as part of this new agreement. "We are very happy to have re-structured our collaboration with Acer Therapeutics which includes provisions that we believe will benefit both parties, and ultimately those suffering from UCDs and other potential rare metabolic conditions," said Jack Weinstein, chief executive officer of Relief Therapeutics. "Our collective goal with Acer is to maximize the global commercialization of OLPRUVA™ to ensure as many patients as possible will access to this much needed, differentiated and convenient treatment alternative." Under the terms of the new agreement, Acer Therapeutics will retain development and commercialization rights for OLPRUVA™ worldwide for the treatment of UCDs and any potential additional indications in the U.S. and other countries worldwide, excluding geographical Europe. Acer Therapeutics will provide Relief Therapeutics with a non-contingent $10 million upfront cash payment and an additional non-contingent $1.5 million cash payment on the one-year anniversary of the agreement. Relief Therapeutics will also receive a 10 percent continuing royalty calculated on the net sales of OLPRUVA™ in the Acer Therapeutics territory, and 20 percent of any value received by Acer Therapeutics from licensing or divestment transactions relating to OLPRUVA™, up to a cumulative amount of an additional $45 million. At the same time, Relief Therapeutics will retain development and commercialization rights for OLPRUVA™ in geographical Europe, which includes the European Union, Liechtenstein, San Marino, Vatican City, Norway, Iceland, Principality of Monaco, Andorra, Gibraltar, Switzerland, United Kingdom, Albania, Bosnia, Kosovo, Montenegro, Serbia and North Macedonia. Acer Therapeutics will receive from Relief Therapeutics a variable, continuing royalty up to a maximum of 10 percent of the net sales of OLPRUVA™ and 20 percent of any value received by Relief Therapeutics from sublicensing transactions relating to OLPRUVA™ in geographical Europe, which going forward exclusively remains Relief Therapeutics' territories to develop and commercialize OLPRUVA™. "Relief Therapeutics remains an ideal partner for OLPRUVA™ in Europe and we are eager to continue the development and commercialization of our innovative treatment option for those suffering from rare metabolic disorders like UCDs," said Chris Schelling, founder and chief executive officer of Acer Therapeutics. In addition to the immediate cash influx strengthening Relief Therapeutics' capital position, the transition from a profit-based model to a revenue-based royalty stream model is expected to offer Relief Therapeutics earlier returns, reduce certain associated risks and increase predictability in its royalty income. This will also support Relief Therapeutics' ongoing operations, extending the cash runway and bolster investments in the Company's pipeline, including its efforts to seek approval to commercialize OLPRUVA™ in geographical Europe. ABOUT OLPRUVA™ The U.S. Food and Drug Administration (FDA) approved ACER-001 (sodium phenylbutyrate) for the treatment of certain UCDs in December 2022 and it is now marketed in the U.S. under the brand name OLPRUVA™. OLPRUVA™ is also being studied as an investigational treatment for patients with maple syrup urine disease (MSUD), a rare metabolic genetic disease that leads to toxic build-up of leucine and other branched-chain amino acids. Please see Important Safety Information and full Prescribing Information, including Patient Information. ABOUT RELIEF THERAPEUTICS Relief Therapeutics is a commercial-stage biopharmaceutical company committed to advancing treatment paradigms and delivering improvements in efficacy, safety and convenience to benefit the lives of patients living with select specialty and rare diseases. Relief Therapeutics' portfolio offers a balanced mix of marketed, revenue-generating products, our proprietary, globally patented Physiomimic™ and TEHCLO™ platform technologies and a targeted clinical development pipeline consisting of risk-mitigated assets focused in three core therapeutic areas, which include rare metabolic, rare dermatology and rare respiratory diseases. In addition, Relief Therapeutics is commercializing several legacy products via licensing to distribution partners. Relief Therapeutics' mission is to provide therapeutic relief to those suffering from rare diseases and is being advanced by an international team of well-established, experienced biopharma industry leaders with extensive research, development and rare disease expertise. Relief Therapeutics is headquartered in Geneva, with additional offices in Balerna, Switzerland, Offenbach am Main, Germany and Monza, Italy. Relief Therapeutics is listed on the SIX Swiss Exchange under the symbol RLF and quoted in the U.S. on OTCQB under the symbols RLFTF and RLFTY. For more information, please visit our website or follow Relief Therapeutics on LinkedIn and Twitter. CONTACT: RELIEF THERAPEUTICS Holding SA Catherine Day Vice President, Investor Relations & Communications catherine.day@relieftherapeutics.com DISCLAIMER This press release contains forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors, including (i) whether Relief Therapeutics and Acer Therapeutics will be successful in their respective development and commercialization efforts for OLPRUVA™, (ii) whether the new transaction structure will prove more or less profitable to Relief Therapeutics than the transaction structure included in the original Collaboration Agreement between the parties, (iii) whether Relief Therapeutics will ultimately be successful in obtaining the right to commercialize OLPRUVA™ in geographical Europe, and (iv) those factors described in Relief Therapeutics' filings with the SIX Swiss Exchange and the U.S. Securities and Exchange Commission (SEC), all of which could cause the actual results, financial condition, performance or achievements of Relief Therapeutics to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Copies of Relief Therapeutics' filings with the SEC are available on the SEC EDGAR database at Relief Therapeutics does not undertake any obligation to update the information contained herein, which speaks only as of this date. SOURCE: RELIEF THERAPEUTICS Holding SA View source version on accesswire.com: