更新于：2024-11-01

Superficial bacterial infection of skin

皮肤浅表细菌感染

更新于：2024-11-01

基本信息

别名

Superficial bacterial infection of skin、Superficial bacterial infection of skin (disorder)、superficial bacterial infection of skin

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简介-

关联

项与皮肤浅表细菌感染相关的药物

Nitrofurazone

呋喃西林

靶点

PFOR

作用机制

PFOR抑制剂

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1945-10-04

项与皮肤浅表细菌感染相关的临床试验

RBR-4kkq2h / Not yet recruiting早期临床1期IIT

Hydrofiber with silver versus colagenase in the control of surface infection and biofilms of venous ulcers: randomized clinical trial

开始日期2019-07-01

申办/合作机构-

TCTR20180828003 / Not yet recruiting临床2期IIT

A randomized, comparative study to assess the efficacy and safety of antimicrobial gauze pad coated with mangosteen extract versus 2% mupirocin ointment in the treatment of uncomplicated superficial bacterial skin infections in children.

开始日期2018-09-03

申办/合作机构

University of Chulalongkorn

CTR20131598 / Completed临床3期

以1 %呋喃西林乳膏为对照的随机III期试验，评价0.02%呋喃西林溶液治疗轻度浅表细菌感染性皮肤病的疗效和安全性

评价每天 3 次湿敷0.02%呋喃西林溶液治疗轻度浅表细菌感染性皮肤病的疗效及安全性。

开始日期2012-07-09

申办/合作机构

海南皇隆制药股份有限公司

100 项与皮肤浅表细菌感染相关的临床结果

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100 项与皮肤浅表细菌感染相关的转化医学

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0 项与皮肤浅表细菌感染相关的专利（医药）

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1,831

项与皮肤浅表细菌感染相关的文献（医药）

2025-01-01·Journal of Orthopaedics

Short-term outcomes with routine use of size ≥40 femoral heads in THA: A retrospective cohort study

Article

作者: Farooq, Hassan ; Hopkinson, William J ; Brown, Nicholas M ; Murphy, Michael P ; Grayson, Whisper ; Brown, Nicholas M. ; Ralles, Steven ; Murphy, Michael P. ; Hopkinson, William J.

BackgroundUsing larger femoral heads during total hip arthroplasty (THA) may result in a more stable hip. Greater volumetric wear and frictional torque, however, may result in increased postoperative complications. The purpose of this study was to compare outcomes of patients with femoral head size ≥40 mm compared to those with femoral head size <40 mm.Materials and methodsA retrospective chart review of 504 THAs performed by a single surgeon at a single institution from 2009 to 2016 was conducted. Following exclusions, 131 THAs were identified with femoral heads ≥40 mm and 348 THAs were identified with femoral heads <40 mm. In addition to demographic data, all postoperative complications were recorded. Plain radiographs were used to rule out/in periprosthetic osteolysis and/or acetabular loosening. Chi-square tests and Student's t-tests were used to compare categorical and continuous variables, respectively.ResultsMean follow-up period for the entire cohort was 5.5 years. Complications with ≥40 mm femoral heads included 1 superficial infection and 1 deep periprosthetic joint infection (PJI). There were no cases of dislocation, osteolysis, acetabular loosening, or trunnionosis. In contrast, complications with <40 mm femoral heads included 9 dislocations and 7 PJIs.ConclusionThe routine use of large femoral heads (≥40-mm) during THA appears to be a safe option for patients at short-term clinical follow-up. Notably, 0 patients had a clinical course complicated by dislocation, osteolysis, acetabular loosening, or trunnionosis.Level of evidenceLevel III Retrospective Cohort Study.

2024-12-01·Injury

Do the results of the OXYGEN trial change if analyzed as “as-treated?”: A secondary analysis of the OXYGEN trial

Article

作者: Obremskey, William ; McKinley, Todd O ; Gary, Joshua L. ; McKinley, Todd O. ; Bosse, Michael J ; Dagal, Arman ; Altman, Gregory T. ; Collins, Susan C ; Firoozabadi, Reza ; D'Alleyrand, Jean-Claude G ; Murray, Clinton K. ; Stall, Alec C ; Huang, Yanjie ; O'Hara, Nathan N ; Weaver, Michael J ; Warner, Stephen J ; Carlini, Anthony R. ; Stall, Alec C. ; Saiz, Augustine M. ; D'Alleyrand, Jean-Claude G. ; Warner, Stephen J. ; Collins, Susan C. ; Murray, Clinton K ; Bosse, Michael J. ; Agel, Julie ; Castillo, Renan C. ; O'Hara, Nathan N. ; O'Toole, Robert V ; O'Toole, Robert V. ; Weaver, Michael J. ; Karunakar, Madhav A ; Paryavi, Ebrahim ; Carlini, Anthony R ; Karunakar, Madhav A. ; Castillo, Renan C ; Altman, Gregory T ; Joshi, Manjari ; Saiz, Augustine M ; Taylor, Tara J. ; Taylor, Tara J ; Gary, Joshua L

OBJECTIVETo determine if the results of the OXYGEN trial changed using an "as-treated" approach instead of the original "intention-to-treat" approach. The multi-center randomized controlled OXYGEN trial aimed to determine the effectiveness of high FiO2 in decreasing infection rates for high-risk tibial plateau, tibial pilon, and calcaneus fractures.METHODSA secondary analysis of a multi-center randomized controlled trial conducted at 29 US trauma centers was performed. A total of 1231 patients aged 18-80 years with tibial plateau, tibial pilon, or calcaneus fractures thought to be at elevated risk of infection were enrolled. Patients were randomly assigned to receive inspired oxygen at a concentration of 80 % FiO2 (treatment) or 30 % FiO2 (control). Adherence was defined using two different criteria. Criterion 1 required at least 80 % of the surgery time ≤40 % FiO2 for the control group or ≥70 % FiO2 for the treatment group. Criterion 2 required at least 80 % of surgery time within 20-40 % (control) or 70-90 % FiO2 (treatment). The primary outcome was surgical site infection (SSI) within 182 days of definitive fracture fixation. Secondary outcomes were deep and superficial surgical site infections within 90, 182, and 365 days of definitive fixation.RESULTSUnder Criterion 1, the primary outcome occurred in 7 % (38/523) and 10 % (49/471) of patients in the treatment and control groups, respectively (p = 0.10). Deep infection occurred in 30 (6 %) treatment and 30 (6 %) control patients (p = 0.75). Superficial infection occurred in 9 (2 %) treatment and 20 (4 %) control patients (RR, 0.41; p = 0.03). Using Criterion 2, the primary outcome occurred in 7 % (36/498) of treatment and 10 % (48/468) of control patients (p = 0.12). Deep infection occurred in 28 (6 %) treatment and 29 (6 %) control patients (p = 0.81). Superficial infection occurred in 9 (2 %) treatment and 20 (4.3 %) control patients (RR = 0.43; p = 0.03).CONCLUSIONSWhen re-analyzing based on which patients actually received high or control levels of perioperative oxygen fraction, the results are somewhat consistent with the original "intent-to-treat" analysis. Specifically, high perioperative oxygen lowered the risk of superficial SSI but did not affect deep infections.

2024-11-01·The Journal of Foot and Ankle Surgery

Open Ankle Fractures in Older Individuals: A Multi-center Study

Article

作者: Van Eck, Carola F ; Elliott, Mark ; Toole, William ; Gauthier, Chase ; Bakaes, Yianni ; Kung, Justin ; Bowman, Erik ; Smoker, Brice ; Nathe, Kristen ; Giakas, Alec M ; Jackson, J Benjamin ; Townsend, Christine ; Grabowski, Gregory ; Boguski, Jonathan

The purpose of this study is to identify demographics, etiology, comorbidities, treatment, complications, and outcomes for older patients with open ankle fractures. Patients ≥60 years old who sustained an open ankle fracture between January 1, 2004 and March 31, 2014 at 6 Level 1 trauma centers were retrospectively reviewed. Univariate analysis using chi-squared or Student's t test was performed to identify associations between preoperative variables and 2 postoperative outcomes of interest: amputation and 1-year mortality. Multivariate analysis was performed using stepwise logistical regression to identify independent predictors of postoperative amputation and 1-year mortality. Of the 162 total patients, the most common mechanism of injury was a ground-level fall (51.9%). The most common fracture types were bimalleolar fractures (52.5%) followed by trimalleolar fractures (26.5%), with 41.5% of the fractures classified as Gustilo Anderson Classification Type 2 and 38.6% classified as Type 3A. The average number of surgeries required per patient was 2.1. Complications included: 15.4% superficial infection rate, 9.9% deep infection rate, and 9.3% amputation rate. The 1-year mortality rate was 13.6% and the overall mortality rate was 25.9%. Male gender and fracture type were found to be independent predictors for amputation after surgery (p = .009, .005, respectively). Older age and having diabetes were independent predictors for 1-year mortality after surgery (p = .021, .005 respectively). Overall, open ankle fractures in older individuals were associated with high rates of amputation and mortality.