呋喃西林(Nitrofurazone) - 药物靶点：PFOR_在研适应症：出血，烧伤，泪囊炎_专利_临床

概要

基本信息

药物类型

小分子化药

别名

5-Nitro-2-furaldehyde semicarbazone、Furacilin、Furancilin

+ [9]

靶点

PFOR

作用机制

PFOR抑制剂(丙酮酸合酶抑制剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

非在研机构

最高研发阶段批准上市

首次获批日期

美国 (1945-10-04),

皮肤疾病

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C6H6N4O4

InChIKeyIAIWVQXQOWNYOU-UHFFFAOYSA-N

CAS号59-87-0

关联

6

项与呋喃西林相关的临床试验

NCT04950647 / Unknown status临床2期IIT

Efficacy and Safety of Nitrazine in the Treatment of Amyotrophic Lateral Sclerosis: a Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study

To evaluate the trend of safety and effectiveness of Nitroketazine tablets for ALS patients, and to explore the best effective dose.

开始日期2020-07-01

申办/合作机构

北京大学第三医院

[+1]

IRCT20190325043107N5 / Recruiting临床3期IIT

The effect of dressing with vaseline gas, nitrofurazone, 2% mupirocin on epithelization, pain and infection at the site of donor skin graft

开始日期2019-07-06

申办/合作机构

Tabriz University of Medical Sciences

IRCT20181216041996N1 / Recruiting临床2/3期IIT

Comparison of dressing with Amniotic membrane and Nitrofurazone ointment in second degree burn wound in THE IMAM KHOMEYNI hospital of URMIA

开始日期2019-01-21

申办/合作机构-

100 项与呋喃西林相关的临床结果

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100 项与呋喃西林相关的转化医学

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100 项与呋喃西林相关的专利（医药）

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978

项与呋喃西林相关的文献（医药）

2024-12-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Rationally design a novel Zn-MOF for fluorescent detection of nitrofuran antibiotics: The synthesis, structure and sensing applications

Article

作者: Ju, Ping ; Li, Anzhang ; Zhang, Guixue ; Zhang, Ensheng ; Jiang, Long ; Zhang, Qingxiang ; Lu, Wenhui

Nitrofuran antibiotics (NFAs) residues in waterare a persistent concern for the public due to the potential threats they pose to human health and the environment. Therefore, efficient probes that are capable of detecting trace amounts of antibiotics in real water environments have become a top priority. Herein, a novel fluorescent Zn-MOF probe (MOF-1) was revealed for the highly selective and sensitive sensing of NFAs. MOF-1 was rationally constructed with Zn(NO₃)₂·6H₂O, 5,5'-(anthracene-9,10-diyl) diisophthalic acid (H₄ADIP) and 1,3-bis(imidazol-1-ylmethyl)-benzene (mbib) by using the solvothermal method. Fluorescence sensing experiments demonstrate that MOF-1 can function as a fluorescent sensor for selective, sensitive, and rapid detection of NFAs among 15 antibiotics including ciprofloxacin (CPFX), chloramphenicol (CAP), sulfonamides and NFAs. Fluorescence titration experiments indicated that MOF-1 exhibited remarkably low detection limits of 0.19 μM, 0.26 μM, and 0.34 μM for furazolidone (FZD), furaltadone (FDH) and nitrofurazone (NFZ), respectively. Meanwhile, MOF-1 was successfully employed for NFAs detection in real samples with the recoveries of 98.7 % - 104.1 %, and a relative standard deviation below 5.1 %. Moreover, the sensing mechanism could be ascribed to the synergistic effect between the internal filtering effect and photoinduced electron transfer according to the experiment results and DFT calculations. Additionally, test strips were prepared based on MOF-1 for point of care testing of NFAs.

2024-11-01·Food Chemistry

Synthesis of P, N-dopped carbon nanosheets for highly sensitive fluorescence analysis of nitrofuran antibiotics in fish

Article

作者: Li, Zhuo ; Dai, Jing ; Guo, Xinrong ; Yang, Huan ; Huang, Huiqun ; Yao, Wen ; Huang, Hongyuan ; Yang, Jie

The misuse of antibiotics has caused serious impacts on food safety and human health, making it crucial to develop rapidly and highly sensitive methods for detecting trace nitrofuran antibiotics (NFs). In this study, phosphorus, nitride-doped carbon nanosheets (PN/CNs) were synthesized using a simple hydrothermal method based on graphitic carbon nitride. This prepared material showed excellent water solubility and stable optical properties. A new fluorescence sensing platform based on PN/CNs was constructed for the highly sensitive detection of four NFs. This sensitivity was mainly attributed to the fluorescence resonance energy transfer (FRET) mechanism. The limits of detection for nitrofurazone, nitrofurantoin, furazolidone and furaltadone were determined to be 13.41, 15.24, 16.37 and 19.94 nM, respectively. The high sensitivity and selectivity of PN/CNs for these four NFs were thoroughly evaluated by the Stern-Volmer equation and FRET quenching efficiency. This proposed method exhibited high sensitivity and can be successfully applied to detect NFs in fish.

2024-10-01·Biosensors and Bioelectronics

Multiple-readout lateral flow immunoassay for the sensitive detection of nitrofurazone metabolites through ultrabright AIE-MOF coupled in-situ growth strategy

Article

作者: Li, Yuechun ; Yin, Xuechi ; Wu, Qiaoying ; Zhang, Daohong ; Cheng, Yuanyuan ; Wang, Shaochi ; Wang, Jianlong ; Xue, Shouyu

The multiple-readout capability of multimodal detection enhances the flexibility, reliability, and accuracy of lateral flow immunoassay (LFIA). The conjugation of two different metal-organic frameworks (MOFs) as a new-generation composite material offers extraordinary opportunities for developing multimodal LFIA. It is anticipated to compensate limitations of traditional single colorimetric signal LFIA and improve the analysis performance. Herein, an ultra-bright fluorescent AIE-MOF was proposed and coupled with an in-situ growth of Prussian blue (PB) nanoparticles strategy to obtain a novel multimodal signal tracer (AIE-MOF@PB). Thereafter, it was successfully applied to develop the multimodal LFIA platform for the detection of nitrofurazone metabolites. The synergy of AIE-MOF and PB endows AIE-MOF@PB with superb water dispersibility, robust fluorescence emission, brilliant colorimetric signal, marvelous photothermal conversion, and enhanced antibody coupling efficiency, all of which facilitate a highly sensitive triple-readout LFIA platform. The detection sensitivity improved by at least 5-fold compared with the colloidal gold-based LFIA. This work not only inspires the rational design of aggregation-induced emission luminogens (AIEgen)-based complex materials but also highlights the promising potential in flexible point-of-care applications.

100 项与呋喃西林相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00862	呋喃西林	P01CC02 S02AA02 S01AX04 D08AF01 D09AA03 B05CA03	DB00336

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
出血	中国	黄石燕舞药业有限公司	1988-01-01
烧伤	中国	湖南湘易康制药有限公司	1981-01-01
泪囊炎	中国	湖南湘易康制药有限公司	1981-01-01
皮炎	中国	湖南湘易康制药有限公司	1981-01-01