别名 DEPRESSIVE DISORDER MAJOR、Depression, Involutional、Depressive Disorder, Major + [72] |
简介 Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) |
作用机制 5-HT1A receptor激动剂 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2023-09-22 |
作用机制 GABAA receptor正向变构调节剂 |
在研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2023-08-04 |
作用机制 多巴胺重摄取抑制剂 [+2] |
在研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2022-11-01 |
开始日期2026-02-01 |
申办/合作机构- |
开始日期2025-12-01 |
申办/合作机构 |
开始日期2025-12-01 |
申办/合作机构 |