A Phase I, Single Centre, Randomised, Interventional, Open-Label, Cross-Over Study to Evaluate the Pharmacokinetics (PK) and the Safety and Tolerability of a Total Daily Dose of 900mg of TETA 4HCL, Comparing a New Once Daily TETA 4HCL Formulation (300mg) (3x300mg Trientine Base Tablets, OD) With the Current Marketed Cuprior® Formulation (150mg) (3x150mg Trientine Base Tablets, BD) in Adult Healthy Male and Female Participants

A randomised, open-label study evaluating the pharmacokinetics, safety, and tolerability of a new once daily dose of 900mg of TETA 4HCL by comparing it against the current marketed Cuprior® formulation (450mg trientine base, twice daily) in healthy male and female participants.

开始日期2024-01-16

申办/合作机构

Orphalan SA

DRKS00028305N/A

Prospective, descriptive, non-interventional, German multicenter study to evaluate the quality of life of Wilson disease patients after switching from D-penicillamine to trientine tetrahydrochloride and to assess clinical and patient reported outcomes - PACUS

开始日期2022-04-01

申办/合作机构-

IRCT20200105046010N34 / Recruiting

In- Vivo Bioequivalence study of Trientine hard capsules 250 mg with brand drug (CYPRINE® 250 mg Merck & Co., Germany) in Iranian healthy volunteers.

开始日期2021-07-01

申办/合作机构-

100 项与四盐酸曲恩汀相关的临床结果

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100 项与四盐酸曲恩汀相关的转化医学

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100 项与四盐酸曲恩汀相关的专利（医药）

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项与四盐酸曲恩汀相关的文献（医药）

2023-02-01·Journal of gastroenterology and hepatology

Experience on switching trientine formulations in Wilson disease: Efficacy and safety after initiation of TETA 4HCl as substitute for TETA 2HCl

Article

作者: Morgil, Müzeyyen ; Poujois, Aurelia ; Mohr, Isabelle ; Bourhis, Hélène ; Morvan, Erwan ; Denk, Gerald ; Woimant, France ; Merle, Uta ; Obadia, Mickael Alexandre ; Weiss, Karl Heinz

Abstract:

Background and Aim:

This retrospective, multicenter study aims to assess the efficacy and safety in Wilson disease (WD) patients treated with trientine tetrahydrochloride (TETA 4HCl) after switch from trientine dihydrochloride (TETA 2HCl).

Methods:

In total, 68 WD patients with stable copper metabolism were identified to receive TETA 4HCl (Cuprior™) after previous treatment with TETA 2HCl. We analyzed biochemical markers such as urinary copper, serum copper, non‐coeruloplasmin bound copper (NCC), and transaminases as well as clinical scores (APRI; FIB‐4 score) at baseline with a follow‐up (FU) of 12 months. Safety of TETA 4HCl treatment was based on reported adverse events (AEs).

Results:

The study cohort reflects a common WD cohort with a mean age of 20.3 years at diagnosis and 38.3 years at baseline. There are no significant differences concerning serum copper, NCC, transaminases, APRI, and FIB‐4 score in the 3‐month FU. Six‐month FU revealed a decreased AST (P = 0.008), APRI (P = 0.042), and FIB‐4 score (P = 0.039). GGT varied only borderline significantly in the 3‐month, but not in the 6‐month FU. Comparison of urinary copper within the subsets did not reveal a difference to baseline in all FUs, suggesting stable control of copper metabolism. Few AEs during TETA 4HCl treatment were reported, most commonly gastrointestinal discomfort. Only three treatments with TETA 4HCl were discontinued.

Conclusion:

Copper parameters and liver function were stable after treatment switch to TETA 4HCl. Treatment with TETA 4HCl was generally well tolerated. This study indicates that the switch from TETA 2HCl to TETA 4HCl is safe and viable.

2022-12-01·The lancet. Gastroenterology & hepatology

Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial

Article

作者: To, Uyen ; Ala, Aftab ; Dubois, Nicolas ; Obadia, Alexandre ; Lachaux, Alain ; Sandahl, Thomas D ; Czlonkowska, Anna ; Weiss, Karl Heinz ; Belmalih, Abdelouahed ; Denk, Gerald ; Schilsky, Michael L ; Cury, Rubens G ; Piechal, Agnieszka ; Patel, Amar ; Langel, Andrea ; Moore, Joanna ; Litwin, Tomasz ; Cassiman, David ; Mohr, Isabelle ; Gerdes, Lisbet ; Couchonnal-Bedoya, Eduardo ; Monico, Sara ; Barbosa, Egberto Reis ; Poujois, Aurelia ; Freitas, Christian ; Cosgrove, Jeremy ; Boogers, Alexandra ; Ott, Peter ; Twardowschy, Carlos ; Giorgini, Alessia ; Hettiarachchi, Daksshi ; Rahli, Djamila ; D'Hollander, Koenraad ; Zuin, Massimo ; Kamlin, C Omar F ; D'Inca, Renata ; Gondim, Francisco de Assis A ; Skowronska, Marta

BACKGROUND:

Wilson disease is an inherited disorder of copper transport. Whereas penicillamine is used therapeutically to re-establish copper balance, trientine is indicated for patients with penicillamine intolerance. We aimed to compare penicillamine with trientine tetrahydrochloride (TETA4) for maintenance therapy in patients with Wilson disease.

METHODS:

We conducted a randomised, open-label, non-inferiority, phase 3 trial at 15 health-care centres across nine countries (patients were recruited from 13 of these health-care centres across Brazil, Europe, and the USA). We enrolled patients aged 18-75 years with stable Wilson disease who were treated for at least 1 year with penicillamine. Patients entered a 12-week period to determine stability through clinical assessment by site investigators and predefined thresholds for serum non-caeruloplasmin-bound copper (NCC; by an exchangeable copper assay; 25-150 μg/L), 24 h urinary copper excretion (100-900 μg/24 h), and alanine aminotransferase (ALT; <2 × upper limit of normal). Stable patients were randomly assigned (1:1) to continue receiving the maintenance twice daily dose of oral penicillamine or switched mg-for-mg to oral TETA4 centrally with a web-based system using minimisation. The primary endpoint, assessed 24 weeks after randomisation, was NCC by speciation assay. The non-inferiority margin of mean difference in NCC by speciation assay was -50 μg/L, as estimated by a general linear model for repeated visits, adjusted for baseline values. Further data on safety and efficacy were collected during a 24-week extension period. Data were analysed using an intention-to-treat approach. Safety was assessed in all patients who received at least one dose of study treatment. This study is registered with ClinicalTrials.gov, NCT03539952 (active, not recruiting).

FINDINGS:

Between June 4, 2018, and March 10, 2020, 77 patients were screened. 53 patients were randomly assigned (27 to the penicillamine group and 26 to the TETA4 group). After 24 weeks, the mean difference in serum NCC by speciation assay between the penicillamine group and TETA4 group was -9·1 μg/L (95% CI -24·2 to 6·1), with the lower limit of the 95% CI within the defined non-inferiority margin. At 24 weeks, urinary copper excretion was lower with TETA4 than with penicillamine (mean difference 237·5 μg/24 h (99% CI 115·6 to 359·4). At 48 weeks, TETA4 remained non-inferior to penicillamine in terms of NCC by speciation assay (mean difference NCC -15·5 μg/L [95% CI -34·5 to 3·6]). Urinary copper excretion at 48 weeks remained in the expected range for well treated patients in both study groups, and the mean difference (124·8 μg/24 h [99% CI -37·6 to 287·1]) was not significantly different. At 24 weeks and 48 weeks, masked clinical adjudication of stability assessed by three independent clinicians confirmed clinical stability (100%) of all participants, in agreement with the stability seen with the NCC by speciation assay. There were no notable changes in either the Clinical Global Impression of Change or Unified Wilson Disease Rating Scale (neurological assessment) from baseline (pre-randomisation) at weeks 24 and 48. The mean change in serum total copper from baseline to 24 weeks was 17·6 μg/L (99% CI -9·5 to 44·7) with penicillamine and -6·3 μg/L (-34·7 to 22·1) with TETA4, and the mean change in serum total caeruloplasmin from baseline to 24 weeks was 1·8 mg/L (-19·2 to 22·8) with penicillamine and -2·2 mg/L (-6·1 to 1·7) with TETA4. All liver enzymes were similar at 24 weeks and 48 weeks, with the exception of elevated ALT concentration at 48 weeks for patients in the TETA4 group. Penicillamine was associated with three post-randomisation serious adverse events (leukopenia, cholangiocarcinoma, and hepatocellular cancer); none were reported for TETA4. The most common treatment-emergent adverse events were headache for penicillamine (five [19%] of 27 patients vs two [8%] of 26) and abdominal pain for TETA4 (one [4%] vs four [15%]); all treatment-emergent adverse events resolved and were mild to moderate. One patient developed a rash with TETA4 that resolved on discontinuation of therapy.

INTERPRETATION:

The efficacy of TETA4 as oral maintenance therapy was non-inferior to penicillamine and well tolerated in adults with Wilson disease.

FUNDING:

Orphalan.

2021-09-01·European journal of drug metabolism and pharmacokinetics4区 · 医学

Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects

4区 · 医学

Article

作者: Weiss, Karl Heinz ; Jackson, Brinley ; Dogterom, Peter ; Morley, Tim ; Kamlin, Camille Omar Farouk ; Amin, Naseem ; Chiou, Yi-Jin ; Thompson, Catherine

BACKGROUND AND OBJECTIVE:

Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism. Chelation of excessive copper is recommended but data on the pharmacokinetics of trientine are limited. The aim of this study was to compare the pharmacokinetics of a new trientine tetrahydrochloride formulation (TETA 4HCl) with those of an established trientine dihydrochloride (TETA 2HCl) salt.

METHODS:

A randomised single-centre crossover study to evaluate the pharmacokinetics, safety and tolerability of two different oral formulations of trientine (TETA 4HCl tablets vs TETA 2HCl capsules) in 23 healthy adult subjects receiving a single dose equivalent to 600 mg of trientine base was performed.

RESULTS:

Following oral administration, the median time to reach maximum plasma concentration (T_max) was 2.00 h (TETA 4HCl) and 3.00 h (TETA 2HCl). The rate (maximum plasma concentration [C_max]) and extent (area under the plasma concentration-time curve from time zero to infinity [AUC_0-∞]) of absorption of the active moiety, trientine, were greater (by approximately 68% and 56%, respectively) for TETA 4HCl than for the TETA 2HCl formulation. The two formulations presented a similar terminal elimination rate (λ_z) and a similar terminal half-life (t_½) for trientine. Differences between TETA 4HCl and TETA 2HCl in the levels of the two main mono- and diacetylated metabolites were less than seen for trientine. For both tested formulations, healthy male volunteers demonstrated higher trientine plasma levels but lower mono- and diacetylated metabolite levels compared with females, with no sex differences in terminal half-life (t_½) observed. Single oral doses of both formulations were safe and well tolerated.

CONCLUSIONS:

Compared with an identical dose of a TETA 2HCl formulation, the TETA 4HCl formulation provided more rapid absorption of trientine and greater systemic exposure in healthy subjects. Clinical Trials Number EudraCT # 2015-002199-25.

项与四盐酸曲恩汀相关的新闻（医药）

2024-10-25

·药时代

买下“废弃管线”后，这家Biotech股价暴涨605.4%

买下“废弃管线”后，这家Biotech股价暴涨605.4%。 2024年10月24日，Monopar Therapeutics宣布与阿斯利康旗下罕见病公司Alexion达成合作，获得 ALXN-1840（四硫钼酸双胆碱）的全球独家许可。根据协议，Monopar将以现金加股权的形式向Alexion支付预付款，具体金额未披露。该消息如同巨石，投下了Monopar长期波澜不惊的二级市场，股价暴涨605.4%，报32.67美元/股。 Monopar的股价 ALXN-1840是一种用于治疗威尔逊病的候选药物，该产品并非阿斯利康原研。2018年4月，Alexion以8.55亿美元的金额并购了Wilson，获得WTX101（后更名为ALXN-1840）。 2021年，阿斯利康斥资390亿美元收购Alexion，除了获得C5补体抑制剂依库珠单抗之外，ALXN-1840也在其中。此次ALXN-1840落入Monopar手中，算是三次易主了。威尔逊病（Wilson disease，WD）学名“肝豆状核变性”，是一种常染色体隐性遗传病，因参与“铜代谢”的基因出了问题，使其功能降低或丧失，肝合成铜蓝蛋白（cNCC）速度减慢，胆汁排铜明显减少，最终导致“铜中毒”。因此临床上，患者多表现为肝脏疾病和神经系统疾病的症状，由于缺乏独特的指征，非常考验医生经验，误诊率很高。威尔逊病发病率约在万分之一到3万分之一之间，在小众疾病里属于发病率较高的。因此，尽管是一种罕见的遗传病，但威尔逊病却并非罕见病。为了便于理解，“铜娃娃”的概念于2011年出现，在中国，成为这类患者的代称。目前，关于“铜娃娃”的治疗包括药物治疗与非药物治疗两大类，药物治疗中主要分为铜螯合剂（青霉胺、曲恩汀、二巯基琥珀酸、四硫钼酸铵、甲烷氧化菌素等）、锌剂、靶向分子治疗、姜黄素及其衍生物。而ALXN-1840就是一种铜螯合剂，属于四硫钼酸铵类似物，即硫四硫钼酸铵二胆碱，较四硫钼酸铵更加稳定。在早期研究中，ALXN-1840展示出了极强的铜结合力，比其他的螯合剂强1万倍。 2018年，当ALXN-1840在Wilson手上的时候，就已经启动了3期临床试验。2021年，阿斯利康接手后跟进3期临床试验，达到主要试验终点。结果显示，ALXN-1840在治疗威尔逊病方面优于标准疗法，其清除体内铜的能力是其他药物的三倍。阿斯利康在2022年财报中表示，ALXN-1840将于2023年下半年获批上市。可世事无常，后续两项规模较小的2期机制试验结果不佳，显示铜在体内重新分布而非被有效清除。 2023年5月，也就是阿斯利康2022年财报公布的2个月后，阿斯利康宣布终止ALXN-1840的开发。为什么两项规模较小的2期机制试验结果，可以影响到阿斯利康的最终决策，即使在三期临床结果阳性的情况下。据悉，ALXN-1840的三期临床FoCus研究主要终点为非铜蓝蛋白接合铜（dNCC），即游离铜。但对患者来说，最致命的是那些藏在器官里的铜，游离铜和结合铜只是间接标准。而两项规模较小的2期机制试验目的就是为了证明，ALXN-1840可以清除器官里的铜。样本量都不大，一个9人，一个31人。主要终点为：患者体内每日铜平衡，以及患者治疗48周后肝铜含量的变化。结果不尽人意，阿斯利康无法证明清除器官里的铜。那么，FoCus的研究结果便没有意义。阿斯利康首席执行官 Pascal Soriot在媒体会上表示：“如果我们不能证明铜确实被清除了，那么就存在一种可能性，铜只是被重新分配到了其他组织中，而非排出体外。” 此次，Monopar愿意买下这条“废弃管线”，原因主要包括两点：（1）ALXN-1840处于临床后期，属于成熟资产，这对只有早期管线的Monopar而言，对公司估值有所帮助，股价表现立竿见影。（2）ALXN-1840与Monopar的联合创始人兼首席执行官Chandler Robinson颇有渊源。早在二十年前，他于西北大学求学期间，便参与了ALXN-1840的早期发现工作，并在《科学》杂志上发表了相关成果。据Chris Starr所述，在阿斯利康宣布停止开发后，威尔逊病协会的患者、医生及董事会成员纷纷呼吁重启ALXN-1840。他认为这是一个机会，并且自己也对该药知根知底，买下了说不定有机会。梦想是要有的，万一成功了呢？封面图来源：pixabay 版权声明/免责声明本文为原创文章。本文仅作信息交流之目的，不提供任何商用、医用、投资用建议。文中图片、视频、字体、音乐等素材或为药时代购买的授权正版作品，或来自微信公共图片库，或取自公司官网/网络，部分素材根据CC0协议使用，版权归拥有者，药时代尽力注明来源。如有任何问题，请与我们联系。衷心感谢! 药时代官方网站:www.drugtimes.cn 联系方式: 电话:13651980212 微信:27674131 邮箱:contact@drugtimes.cn 为什么中国创新药企，缺少商业化能力？有救了！30分钟改善老花眼！箕星药业这次算是押中了重要新政！生物制品分段生产试点工作启动点击查看更多精彩！

财报并购临床3期

2024-09-02

·Pharma CMC

刚刚，79个新批件，一款罕见病药物获批上市！

刚刚，NMPA发布2024年09月02日药品批准证明文件送达信息，本批次共有79个受理号获批，其中59个为上市申请受理号，获批品种包括：江苏正大清江制药的磷酸奥司他韦干混悬剂；齐鲁制药、昆山龙灯瑞迪制药的达格列净片；平光制药的己酮可可碱注射液；贵州益佰制药的普乐沙福注射液；北京诚济制药的布洛芬混悬液；北京福元医药的丙戊酸钠缓释片（I）等。此外，杰谛医药引进的盐酸曲恩汀胶囊获批上市，用于治疗对不能耐受青霉胺的肝豆状核变性（又称Wilson病）成人及儿童患者。据公开资料显示，盐酸曲恩汀胶囊是一款铜离子络合剂，作用类似青霉胺，可以促使铜通过肾脏排出体外。该药最早由德国默克开发，1985年在美国获批上市，用于治疗威尔逊病，可供不能耐受青霉胺的患者选用。原研药至今未在国内上市。 2023年3月，杰谛医药递交5.2类化药盐酸曲恩汀胶囊的上市申请，后续其上市申请被纳入优先审评。

上市批准优先审批

2024-08-19

·PRNewswire

Behind The Mystery Unveils Treatment in Wilson Disease with Cuviror® by Orphalan

Wilson Disease, a rare, genetic disorder, hampers the body's ability to eliminate copper, leading to serious health issues. Cuvrior® (trientine tetrahydrochloride) is the only FDA-approved treatment in nearly 30 years. FORT LAUDERDALE, Fla., Aug. 19, 2024 /PRNewswire/ -- This special episode of Behind the Mystery features insightful discussions with a dedicated physician, an advocacy leader, and a CEO whose company has pioneered the first FDA approved treatment for Wilson Disease in nearly 30 years. Mandy, diagnosed with Wilson Disease at a young age, shares her journey living with the condition on the show, addressing the challenges faced by patients in managing their treatment regimens and the need for more convenient options. In addition, Hepatologist Dr. Cheung delves into the complexities of Wilson Disease, including its genetic origins, symptoms, and the critical importance of early diagnosis, management, and adherence to treatment. "I'm proud to be part of the 'Behind the Mystery' team, where we use our platform to raise awareness for the rare disease community. Our series underscored the immense challenges faced by patients, as well as the dedication of physicians, the pharmaceutical industry, and advocacy leaders to provide meaningful solutions to the community," said Senior Writer and Producer of Behind the Mystery, Brittany Cocilova. Our latest episode highlights Orphalan's commitment to developing the only FDA-approved therapy for Wilson Disease in nearly 30 years, showcasing the continued efforts to help patients living with and managing their rare disease. Hosts Montel Williams and Olga Villaverde spotlight the Wilson Disease Association's (WDA) efforts to support patients, improve awareness, and facilitate access to developments. Rhonda Rowland, VP of the WDA, discusses the evolution of treatment options and the organization's role in fostering partnerships between patients, physicians, and the pharmaceutical industry. "Orphalan has a tremendous commitment to educating not only the Wilson Disease community and the general public, but also physicians," says Rhonda Rowland, Vice President of Wilson Disease Association. "We've seen a partnership evolve between advocacy and the pharmaceutical industry which enables an open line of communication addressing the unmet needs in our community." Dr. Naseem Amin, CEO of Orphalan, details how Orphalan is addressing unmet needs in the patient community and emphasizes the importance of empathy in the pharmaceutical industry. CUVRIOR®, a treatment marketed by Orphalan, offers a twice-daily dosing and is a non-refrigerated option for long-term maintenance therapy for Wilson Disease. Behind the Mystery - Wilson Disease will air on Lifetime on August 19th and August 27th at 7:30 AM ET/PT and will remain on the website. By sharing these intimate narratives, the series aims to educate the public, inspire empathy, and advocate for better research, treatments, and support systems. INDICATION CUVRIOR is a copper chelator indicated for the treatment of adult patients with stable Wilson Disease who are de-coppered and tolerant to penicillamine. IMPORTANT SAFETY INFORMATION Do not use CUVRIOR if you are allergic to trientine or to any of the ingredients in CUVRIOR. Your Wilson's Disease symptoms could get worse when you start treatment. This could happen because too much copper is removed from the body in a short period of time. Your doctor may need to reduce your dose or stop CUVRIOR treatment. Copper deficiency may develop following treatment with CUVRIOR. Your doctor will do tests to monitor your urine and blood for copper. Iron deficiency may develop while taking CUVRIOR. If this happens, your doctor may tell you to take iron supplements for a limited time. Allergic reactions, such as a rash, have been reported with trientine, the active ingredient in CUVRIOR. If a rash or other allergic reaction occurs, stop taking CUVRIOR and get emergency medical help. The most common side effects are pain in the abdomen, change in bowel habits, rash, hair loss (alopecia), and mood swings. Take CUVRIOR at least 1 hour apart from any other oral medicine. Tell your doctor about all the medicines you're taking, including over-the-counter medicines, vitamins, and herbal supplements. Avoid taking supplements when taking CUVRIOR. Taking CUVRIOR with mineral supplements (e.g., iron, zinc, calcium, magnesium) can reduce the effectiveness of CUVRIOR. If iron supplementation is necessary, take CUVRIOR at least 2 hours before or 2 hours after taking iron; for other mineral supplements (e.g., zinc, calcium, magnesium), take CUVRIOR at least 1 hour before or 2 hours after. Do not start or stop any medicines while taking CUVRIOR without talking to your doctor. These are not all the possible side effects of CUVRIOR. You are encouraged to report negative side effects of prescription drugs. Contact Orphalan at 1-800-961-8320 or [email protected] or FDA at 1-800-FDA-1088 or medwatch. Please see full Prescribing Information at: About Behind the Mystery: Behind the Mystery™ is the first and only television series dedicated to raising awareness about rare and genetic diseases through powerful patient storytelling. Each episode delves into the personal journeys of individuals and families affected by these conditions, highlighting their struggles, triumphs, and daily realities. By sharing these intimate narratives, the series aims to educate the public, inspire empathy, and advocate for better research, treatments, and support systems. Behind the Mystery not only sheds light on the medical aspects of rare diseases but also celebrates the resilience and strength of the human spirit. Join us weekday mornings on Lifetime®. About Orphalan Orphalan is an international orphan drug development and commercialization company headquartered in Paris. Founded in 2011, the company develops innovative therapies for people living with rare and debilitating diseases. Our trientine tetrahydrochloride product for the treatment of Wilson disease is approved and available in more than 20 countries, branded as CUPRIOR® in EU, the UK, Saudi Arabia, Switzerland, Columbia and China, and as CUVRIOR® in the United States. For more information visit and follow us on LinkedIn. SOURCE Behind The Mystery

孤儿药上市批准

100 项与四盐酸曲恩汀相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肝豆状核变性	欧盟	Orphalan SA	2017-09-05
肝豆状核变性	冰岛	Orphalan SA	2017-09-05
肝豆状核变性	列支敦士登	Orphalan SA	2017-09-05
肝豆状核变性	挪威	Orphalan SA	2017-09-05

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03539952 (EASL2021)	临床3期	肝豆状核变性维持 non-ceruloplasmin copper;(NCC)	53	D-penicillamine	膚遞膚築壓築膚鹹鬱蓋(醖網壓醖範選膚鹹願積) = 遞壓醖鑰觸鏇觸鏇繭壓遞鑰鹹齋鹹遞齋簾鏇壓 (鏇蓋積選鏇襯範鏇鹽鏇 )	积极	2021-06-23
				TETA4	膚遞膚築壓築膚鹹鬱蓋(醖網壓醖範選膚鹹願積) = 蓋膚鑰鏇壓糧顧鬱築淵遞鑰鹹齋鹹遞齋簾鏇壓 (鏇蓋積選鏇襯範鏇鹽鏇 )
ESC2017	N/A	肥大型心肌病 Copper	20	Trientine dihydrochloride	繭鹽襯廠築築簾顧積範(衊積醖製壓鹹願製觸糧) = 網範醖積繭憲願繭繭繭繭艱廠淵願蓋窪範鹽窪 (鹹觸糧糧餘壓餘鬱餘鏇 ) 更多	-	2017-08-28
				trientine	繭鹽襯廠築築簾顧積範(衊積醖製壓鹹願製觸糧) = 衊鬱範艱顧蓋壓鹽鹹顧繭艱廠淵願蓋窪範鹽窪 (鹹觸糧糧餘壓餘鬱餘鏇 ) 更多