A Randomized Prospective Clinical Trial to Evaluate Efficacy and Safety of LACUDY for Improving Vaginal Environment Among Breast Cancer Survivals Who Receive Anti-estrogen Therapy

Adjuvant hormone treatments for early breast cancer are associated with frequent bothersome side effects with major negative impact on patients' quality of life and treatment adherence. Patients most commonly report menopausal symptoms including vaginal dryness, vaginal bleeding, and dyspareunia. Even though previous studies have reported that estrogen topical agent relives these symptoms, non-hormonal therapy should be considered first due to concerns about the role of estrogen in breast cancer development. Therefore, this trial is planned to evaluate the efficacy and safety of LacuD (hyaluronic acid, lactic acid and alginate) in the vaginal environment of breast cancer patients receiving hormone therapy.

开始日期2022-12-20

申办/合作机构

Kyungpook National University Hospital

100 项与海藻酸钠相关的临床结果

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100 项与海藻酸钠相关的转化医学

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100 项与海藻酸钠相关的专利（医药）

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项与海藻酸钠相关的文献（医药）

2024-12-01·FOOD CHEMISTRY

Alaska pollock surimi-based meat analogs by high-moisture extrusion: Effect of konjac glucomannan/curdlan/carrageenan/sodium alginate on fibrous structure formation

Article

作者: Tu, Xin ; Xia, Songgang ; Yang, Liuwei ; Xue, Yong ; Wang, Lei ; Yu, Jing ; Xue, Changhu

This study investigated the effects of the addition of konjac glucomannan (KGM), curdlan (CD), carrageenan (CA), and sodium alginate (SA) on fibrous structure formation in surimi-based meat analogs to livestock meat. Meat analogs were prepared using high-moisture extrusion with Alaskan pollock surimi and soy protein isolate at a ratio of 7:3 (w/w). The meat analogs samples were labeled as SSP. Macrostructure observation showed that the best fibrous structure was obtained in SSP containing 2% SA. Mesostructure and microstructure observations revealed that 2% CD, CA or SA promoted the formation of a less tight three-dimensional network structure, which contributed to the formation of fiber filaments. Increased β-sheet structure content, ordered degree, fractal dimension and thermal stability were observed in SSP with the three colloids. Moreover, fibrous texture was closely associated with the thermal stability and fractal dimension. This study has provided useful information for colloid application in surimi-based meat analogs.

2024-12-01·JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Doxycycline‐loaded carboxymethyl cellulose/sodium alginate/gelatin hydrogel: An approach for enhancing pressure ulcer healing in a rat model

Article

作者: Alizadeh, Morteza ; Salehi, Majid ; Aldaghi, Niloofar ; Kamalabadi‐Farahani, Mohammad

Abstract:

Pressure ulcers, or bedsores, are created by areas of the skin under prolonged pressure and can lead to skin and underlying tissue damage. The present study evaluated the effects of carboxymethyl cellulose/sodium alginate/gelatin (CMC/Alg/Gel) hydrogel containing doxycycline (DOX) on improving the healing process of pressure ulcers. The magnet was used to apply pressure on the dorsum skin rat to induce a pressure ulcer model. Then sterile gauze, CMC/Alg/Gel, and CMC/Alg/Gel/1% w/v DOX hydrogels were used to cover the wounds. Blood compatibility, weight loss, cytocompatibility, drug release rate, cell viability, wound closure, and re‐epithelialization were evaluated in all animals on the 14th day after treatment. In vivo results and histopathological evaluation showed 56.66% wound closure and the highest re‐epithelialization in the CMC/Alg/Gel/1% w/v DOX hydrogel group (14 days after treatment). Furthermore, real‐time PCR results indicated that the hydrogel containing DOX significantly decreased the expression of the MMP family consisting of MMP2 and MMP9 mRNA and also increased the expression of vascular endothelial growth factor VEGF mRNA. This study suggested that the addition of DOX, an antibiotic and MMP inhibitor, to hydrogels may be effective in the healing process of pressure ulcers.

2024-12-01·EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evaluation of a mucoadhesive auto-nanoemulsifying drug delivery system (SNEDDS) for oral insulin administration

Article

作者: Bravo-Alfaro, Diego A. ; Mendoza-Sánchez, L G ; Garcia, Hugo S. ; Bravo-Alfaro, Diego A ; Mendoza-Sánchez, L.G. ; Luna-Barcenas, Gabriel ; Muñoz-Correa, M O F ; Garcia, Hugo S ; Garcia-Varela, Rebeca ; Muñoz-Correa, M.O.F.

This study investigated the potential of self-nanoemulsifying drug delivery systems (SNEDDS) to optimize the oral bioavailability of insulin. Insulin complexes with phospholipids and enzymatically-modified phospholipids were developed and incorporated into the SNEDDS using Lauroglycol FCC as the oily phase and Cremophor EL and Labrafil M1944CS as the surfactant and co-surfactant, respectively. Additionally, mucoadhesive polysaccharides (sodium alginate and guar gum) were added further to enhance the bioavailability of insulin in these systems. The objective was to increase the bioavailability and bioactivity of an insulin-modified phosphatidylcholine complex by incorporating mucoadhesives into the SNEDDS. After polymer inclusion, the resulting nanoemulsions exhibited droplet diameters ranging from 57 to 83 nm. Cytotoxicity and apparent permeability tests were conducted on Caco-2 and NIH 3 T3 cell lines, revealing that toxicity was related to the concentrations of insulin and surfactant in the nanosystems-formulations containing guar gum as a mucoadhesive showed better tolerance to cell death in the Caco-2 line. In a murine diabetes model, the SNEDDS were observed to reduce glucose levels by up to 61.63 %, with a relative bioavailability of 2.25 % compared to subcutaneously administered insulin. These results suggest that SNEDDS incorporating mucoadhesives could represent a promising strategy for improving oral insulin delivery.

项与海藻酸钠相关的新闻（医药）

2024-04-09

·蒲公英Ouryao

药典委：乙醇、山梨酸等13种辅料标准公示

来源：国家药典委编辑：wangxinglai2004近日，国家药典委发布了13则辅料标准公示，涉及品种包括泊洛沙姆40、泊洛沙姆188、无水乙醇、丁香酚、海藻酸钠、乙醇、山梨酸钾、山梨酸、橄榄油等，其中乙醇、山梨酸钾、山梨酸、橄榄油公示期为1个月，其余品种全部为3个月。 01 泊洛沙姆407国家药用辅料标准我委拟修订泊洛沙姆407国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见，具体如下：重点内容说明：性状：根据《国家药用辅料标准编写细则（2023 年暂行版）》，微有异臭的描述不便于试验验证，故删除此描述；另外将溶解度放在正文最后，以注的形式体现。氧乙烯：2020 年版《中国药典》中 A1为 1.15×10-6 处双峰的积分面积，代表氧丙烯的甲基，因征集样品的核磁图显示，该处的峰型不一定是双峰，将此处的描述修订为“A1 为约 1.15×10-6 处峰的积分面积”。二丁基羟基甲苯（标示含二丁基羟基甲苯时测定）：2020 年版《中国药典》中的供试品溶液在室温较低时会出现析出的情况，故将原标准中的供试品浓度和对照品浓度降低一半，进样体积增加一倍，可避免析出。将供试品浓度由100mg/ml 修订为 50mg/ml，对照品浓度由 20µg/ml 修订为 10µg /ml；进样体积由1µl 修订为 2µl，绝对进样量不变。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 02 泊洛沙姆188国家药用辅料标准我委拟修订泊洛沙姆188国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见，具体如下：重点内容说明：性状：根据《国家药用辅料标准编写细则（2023 年暂行版）》，微有异臭的描述不便于试验验证，故删除此描述；另外将溶解度放在正文最后，以注的形式体现。氧乙烯：2020 年版《中国药典》中 A1 为 1.15×10-6 处双峰的积分面积，代表氧丙烯的甲基，因征集样品的核磁图显示，该处的峰型不一定是双峰，将此处的描述修订为“A1 为约 1.15×10-6 处峰的积分面积”。二丁基羟基甲苯（标示含二丁基羟基甲苯时测定）：2020 年版《中国药典》中的供试品溶液在室温较低时会出现析出的情况，故将原标准中的供试品浓度和对照品浓度降低一半，进样体积增加一倍，可避免析出。将供试品浓度由100mg/ml 修订为 50mg/ml，对照品浓度由 20µg/ml 修订为 10µg /ml；进样体积由1µl 修订为 2µl，绝对进样量不变。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 03 海藻酸钠国家药用辅料标准我委拟修订海藻酸钠国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 04 乙醇国家药用辅料标准我委拟修订乙醇国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起一个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 05 丁香酚国家药用辅料标准我委拟修订丁香酚国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 06 二甲硅油国家药用辅料标准我委拟修订二甲硅油国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 07 山梨醇国家药用辅料标准我委拟修订山梨醇国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 08 无水枸橼酸国家药用辅料标准我委拟修订无水枸橼酸国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 09 山梨酸钾国家药用辅料标准我委拟修订山梨酸钾国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起一个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 10 山梨酸国家药用辅料标准我委拟修订山梨酸国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起一个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 11 无水乙醇国家药用辅料标准我委拟修订无水乙醇国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566，67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 12 黑氧化铁国家药用辅料标准我委拟修订黑氧化铁国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起三个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566、67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061 13 橄榄油国家药用辅料标准我委拟修订橄榄油国家药用辅料标准。为确保标准的科学性、合理性和适用性，现将拟修订的标准公示征求社会各界意见（详见附件）。公示期自发布之日起一个月。请认真研核，若有异议，请及时在线反馈，并附相关说明、实验数据和联系方式。来函需打印后加盖公章，个人来函需打印后本人签名，并邮寄至我委通讯地址。公示期满未回复意见即视为对公示标准草案无异议。联系人：陈蕾、朱冉电话：010-67079566,010-67079581 通信地址：北京市东城区法华南里11号楼国家药典委员会办公室邮编：100061

申请上市

2023-06-21

·Science Daily

Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment

Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects. Probiotics can help maintain a healthy gut microbiome or restore populations of "good bacteria" after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers reporting in ACS Central Science have developed a microgel delivery system for probiotics that keeps "good" bacteria safe while actively clearing out "bad" ones. In mice, the system treated intestinal inflammation without side effects. In the digestive system, there's a delicate balance of bacterial populations. When this balance is disrupted, bad bacteria can take over the colon, causing it to swell, resulting in colitis. Certain diseases, including inflammatory bowel disease and Crohn's disease, involve chronic colitis and currently require immunosuppressants to treat them. These drugs are expensive and non-specific, sometimes giving rise to antibiotic-resistant bacteria. An alternative strategy is to deliver beneficial bacteria, or probiotics, to help restore balance. But to reach the colon, a treatment must first pass through stomach acid, withstand being cleared out by the intestine, then fight for space alongside the numerous invading bacteria. Pairing probiotics with a drug delivery system could make this strategy feasible, though most current approaches simply protect the probiotics from digestion without affecting the microbes responsible for the condition. So, Zhenzhong Zhang, Junjie Liu, Jinjin Shi and colleagues wanted to combine probiotics with specialized microgel spheres that could not only protect the good bacteria, but also actively help clear out the bad. To create their system, the researchers combined sodium alginate, tungsten and calcium-containing nanoparticles into small, spherical microgels, then coated them with beneficial, probiotic bacteria. The gels protected the bacteria as they made their way through the stomach and increased their retention time in the colon. Once there, calprotectin proteins -- highly expressed during colitis -- bound to the calcium and disassembled the gels, allowing the tungsten to escape. By displacing molybdenum in a key enzyme substrate of the bad bacterium Enterobacteriaceae, tungsten inhibited the microbe's growth while leaving the probiotics unaffected. In experiments using a colitis mouse model, the system allowed probiotics to proliferate in the intestine without any side effects. Additionally, mice with the microgel spheres did not exhibit many of the hallmarks of colitis, such as shortened colons or damaged intestinal barriers, showing that the delivery system could be a viable treatment strategy. Though the researchers also want to prove its utility in more advanced preclinical models, they say that this work provides a new perspective into treatments using colonizing probiotics. The authors acknowledge funding from the National Natural Science Foundation of China, the Outstanding Youth Foundation of Henan Province and the China Postdoctoral Science Foundation.

2023-05-17

·Science Daily

An edible CBD coating could extend the shelf life of strawberries

Soon, you'll be able to get a box of freshly picked, sweet strawberries from the grocery store or local farm stand. But it's disappointing when you get them home and find that the ones at the bottom have started to rot. To increase the berries' shelf life, researchers have incorporated cannabidiol -- a non-hallucinogenic compound from cannabis known as CBD -- and sodium alginate into an edible antimicrobial coating. Soon, you'll be able to get a box of freshly picked, sweet strawberries from the grocery store or local farm stand. But it's disappointing when you get them home and find that the ones at the bottom have started to rot. To increase the berries' shelf life, researchers reporting in ACS Applied Materials & Interfaces have incorporated cannabidiol -- a non-hallucinogenic compound from cannabis known as CBD -- and sodium alginate into an edible antimicrobial coating. CBD is popular because of its potential therapeutic effects. But this cannabinoid has also been shown to have antioxidant and antimicrobial properties. In previous studies, CBD limited the growth of some bacteria and pathogenic fungi, such as the ones that cause fresh fruits and vegetables to rot. However, the oily compound needs to be evenly distributed in water before it can be widely incorporated into foods or used for food preservation. One possible way to do this is to encapsulate the CBD molecules in edible polymers. So, Pongpat Sukhavattanakul, Sarute Ummartyotin and colleagues wanted to see if a food coating made using CBD-filled nanoparticles could promote antimicrobial activity and extend the freshness of strawberries. The researchers encapsulated CBD in poly(D,L-lactide-co-glycolide), a biodegradable polymer used in drug delivery, producing 400-nm-wide particles. They mixed the most stable nanoparticles, containing 20% by weight CBD, with sodium alginate in water. Strawberries were then submerged into solutions containing different amounts of nanoparticles before a second dip into a mixture of ascorbic acid and calcium chloride to turn the colorless coating into a gel. Untreated and treated strawberries were then placed in open plastic containers at refrigerator temperatures. After 15 days, CBD-treated samples ripened and decayed much more slowly than untreated ones, possibly because of reduced microbial growth. The coating with the most CBD-loaded nanoparticles preserved the berries' dark red appearance, enhanced their antioxidant activity the most and exhibited the largest antimicrobial protection over the storage period, suggesting that this version would lead to the longest shelf life. The researchers say that their results demonstrate how encapsulated CBD could be used to create a colorless antimicrobial coating for active food packaging.

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KEGG	Wiki	ATC	Drug Bank
D03336	-	-	-

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适应症	国家/地区	公司	日期
十二指肠溃疡	日本	Kaigen Pharma Co., Ltd.	2009-06-26
糜烂性胃炎	日本	Kaigen Pharma Co., Ltd.	2009-06-26
反流性食管炎	日本	Kaigen Pharma Co., Ltd.	2009-06-26
出血	日本	Kaigen Pharma Co., Ltd.	2009-06-26
胃溃疡	日本	Kaigen Pharma Co., Ltd.	2009-06-26

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适应症	最高研发状态	国家/地区	公司	日期
胃食管反流	临床3期	中国	北京和必康科技发展有限公司	2013-06-05
胃食管反流	临床3期	中国	Reckitt Benckiser Healthcare (UK) Ltd.	2013-06-05