LIGHTBEAM-U01 Substudy 01B: A Phase 1/2 Substudy to Evaluate the Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors

This study is a rolling arm study of pembrolizumab in combination with investigational agents in pediatric participants with relapsed or refractory classical Hodgkin lymphoma (cHL) solid tumors with microsatellite instability-high (MSI-H)/mismatch repair deficient (dMMR) or tumor mutational burden-high (TMB-H). This study will have 2 parts: a safety lead-in to demonstrate a tolerable safety profile and confirm a preliminary recommended phase 2 dose (RP2D) (Part 1) followed by an efficacy evaluation (Part 2). Participants will be assigned to a treatment arm (either Part 1 or Part 2) that is open for enrollment.
There will be no hypothesis testing in this study.

开始日期2025-01-15

申办/合作机构

Merck Sharp & Dohme LLC

NCT03598608

/ Completed临床1/2期

A Phase 1/Phase 2 Clinical Study to Evaluate the Safety and Efficacy of a Combination of MK-4280 and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies

This study will evaluate the safety and efficacy of favezelimab (MK-4280) in combination with pembrolizumab (MK-3475) using a non-randomized study design in participants with the following hematological malignancies:
* classical Hodgkin lymphoma (cHL)
* diffuse large B-cell lymphoma (DLBCL)
* indolent non-Hodgkin lymphoma (iNHL)
This study will also evaluate the safety and efficacy of pembrolizumab or favezelimab administered as monotherapy in participants with cHL using a 1:1 randomized study design.
The study will have 2 phases: a safety lead-in and an efficacy expansion phase. The recommended Phase 2 dose (RP2D) will be determined in the safety lead-in phase by evaluating dose-limiting toxicities.
There is no primary hypothesis for this study.

开始日期2018-10-17

申办/合作机构

Merck Sharp & Dohme LLC

NCT03516981

/ Completed临床2期

A Phase 2 Precision Oncology Study of Biomarker-Directed, Pembrolizumab-(MK-3475, SCH 900475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (KEYNOTE-495; KeyImPaCT)

This study will investigate the utility of biomarker-based triage for study participants with advanced non-small cell lung cancer (NSCLC) without prior systemic therapy. Study participants within groups defined by a biomarker-based classifier (gene expression profile [GEP] and tumor mutational burden [TMB]) will be randomized to receive pembrolizumab in combination with quavonlimab (MK-1308), favezelimab (MK-4280), or lenvatinib. The primary hypotheses are as follows: In participants receiving pembrolizumab in combination with either quavonlimab, favezelimab, or lenvatinib, the Objective Response Rate (ORR) will be 1) greater than 5% among participants with low GEP and low TMB, 2) greater than 20% among participants with low GEP and high TMB, 3) greater than 20% among participants with high GEP and low TMB, and 4) greater than 45% among participants with high GEP and high TMB.

开始日期2018-10-01

申办/合作机构

Merck Sharp & Dohme Corp.

100 项与 Favezelimab 相关的临床结果

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100 项与 Favezelimab 相关的转化医学

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100 项与 Favezelimab 相关的专利（医药）

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项与 Favezelimab 相关的文献（医药）

2026-02-01·ANNALS OF ONCOLOGY

Novel pembrolizumab-based treatments as first-line therapy in advanced clear-cell renal cell carcinoma: substudy 03A of the open-label, umbrella platform, phase I/II KEYMAKER-U03 trial

Article

作者: Shin, S J ; Hammers, H ; Dziadziuszko, R ; Suttner, L ; Lee, J-L ; Miller, W H ; Peer, A ; Keizman, D ; Zwenger Kloster, A ; Burgents, J E ; Powles, T ; Rojas, C ; Waddell, T ; Weickhardt, A ; Motzer, R ; Suarez, C ; Yanez Weber, P ; Neiman, V ; Sharma, M ; Albiges, L

BACKGROUND:

First-line triplet therapy may expand clinical benefit for advanced clear-cell renal cell carcinoma (ccRCC). The phase Ib/II KEYMAKER-U03 substudy 03A (NCT04626479) investigated novel pembrolizumab (pembro)-based regimens in this setting.

PATIENTS AND METHODS:

Participants with advanced ccRCC and no prior systemic therapy were randomized 2 : 1 to quavonlimab (qmab)/pembro plus lenvatinib (lenva), favezelimab (fave)/pembro plus lenva, pembro plus lenva plus belzutifan (bel), and vibostolimab (vibo)/pembro plus bel or a concurrent reference treatment (pembro plus lenva). A safety lead-in of ∼10 participants occurred for all investigative treatments before randomization. Primary endpoints were objective response rate (ORR) per RECIST v1.1 by blinded independent central review in all randomized participants (excluding safety lead-in), and safety in all treated participants. Secondary endpoints included progression-free survival (PFS) and overall survival (OS).

RESULTS:

As of 31 March 2025, 393 participants were enrolled. Median follow-up for randomized participants across the five cohorts ranged between 16 and 39 months. The ORR was 80.6% [95% confidence interval (CI) 68.6% to 89.6%] with pembro plus lenva, 71.3% (95% CI 60.0% to 80.8%) with qmab/pembro plus lenva, 62.7% (95% CI 48.1% to 75.9%) with fave/pembro plus lenva, 77.5% (95% CI 66.8% to 86.1%) with pembro plus lenva plus bel, and 42.5% (95% CI 31.5% to 54.1%) with vibo/pembro plus bel. Median PFS was 26.3 months (95% CI 15.3-39.8 months) with pembro plus lenva, 18.0 months (95% CI 11.6-34.3 months) with qmab/pembro plus lenva, 26.0 months (95% CI 8.2-31.8 months) with fave/pembro plus lenva, 31.8 months [95% CI 26.3 months-not reached (NR)] with pembro plus lenva plus bel, and 15.2 months (95% CI 12.4 months-NR) with vibo/pembro plus bel. Median OS was not reached in any arm. Grade ≥3 treatment-related adverse events occurred in 71.0% (44/62) of participants treated with pembro plus lenva, 73.3% (66/90) with qmab/pembro plus lenva, 86.9% (53/61) with fave/pembro plus lenva, 70.0% (63/90) with pembro plus lenva plus bel, and 68.9% (62/90) with vibo/pembro plus bel.

CONCLUSIONS:

Observed efficacy and safety of pembro plus lenva were confirmatory of prior observations for this combination. ORR was similar to reference for pembro plus lenva plus bel and qmab/pembro plus lenva, but not the other investigative arms. Further investigation of pembro plus lenva plus bel and qmab/pembro plus lenva versus pembro plus lenva is ongoing in the phase III LITESPARK-012 study.

2025-10-14·Blood Advances

Estimating efficacy of favezelimab plus pembrolizumab relative to pembrolizumab in anti–PD-1–refractory Hodgkin lymphoma

Article

作者: Pillai, Pallavi ; Lavie, David ; Herrera, Alex F. ; Timmerman, John ; Thiagarajan, Kannan ; Armand, Philippe ; Topp, Brian G. ; Johnson, Nathalie A. ; Zinzani, Pier Luigi

Abstract:

Favezelimab plus pembrolizumab had promising efficacy in anti–programmed cell death protein 1 (PD-1)–refractory classical Hodgkin lymphoma in MK-4280-003; however, the contribution of favezelimab was unclear. Here, we assessed the relative contribution of favezelimab by comparison with data from participants treated with only pembrolizumab beyond progression in KEYNOTE-087. Participants in MK-4280-003 had received ≥2 doses of anti–PD-1 therapy and progressed <12 weeks of last dose. Participants eligible from KEYNOTE-087 had received >2 doses of pembrolizumab beyond progression, and progressed <12 weeks of last dose. Participants received pembrolizumab 200 mg plus favezelimab 200 mg or 800 mg, or pembrolizumab 200 mg IV every 3 weeks. Change in target lesion size and response per International Working Group 2007 criteria were assessed. Baseline tumor size was reset at first progression for KEYNOTE-087. A bootstrapping method compared change in target lesion size between groups. Twenty-seven participants from MK-4280-003 and 81 from KEYNOTE-087 were included. Objective response rates were 37% (95% confidence interval [CI], 15-51) for favezelimab plus pembrolizumab, and 2% (95% CI, 0-6) for pembrolizumab alone. A clinically meaningful reduction (≥50%) in target lesion size was observed in 13 (48%) vs 4 participants (5%), respectively. The mean change from baseline in target lesion size was −49% and −0.4%. In the bootstrapping analysis, 99.4% of samples showed greater decrease in tumor burden with favezelimab plus pembrolizumab. Favezelimab plus pembrolizumab had a higher response rate and greater reduction in tumor burden vs pembrolizumab alone in anti–PD-1–refractory classical Hodgkin lymphoma, suggesting favezelimab contributed substantially to efficacy in MK-4280-003. The trials were registered at www.clinicaltrials.gov as #NCT03598608 and #NCT02453594.

2023-10-01·STRUCTURE

CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker

Article

作者: Agnihotri, Pragati ; Hasan, S Saif ; Kolesnikov, Alexander ; Karade, Sharanbasappa S ; Mariuzza, Roy A ; Mishra, Arjun K ; Shahid, Salman

Lymphocyte activation gene 3 protein (LAG3) is an inhibitory receptor that is upregulated on exhausted T cells in tumors. LAG3 is a major target for cancer immunotherapy with many anti-LAG3 antibodies in clinical trials. However, there is no structural information on the epitopes recognized by these antibodies. We determined the single-particle cryoEM structure of a therapeutic antibody (favezelimab) bound to LAG3 to 3.5 Å resolution, revealing that favezelimab targets the LAG3-binding site for MHC class II, its canonical ligand. The small size of the complex between the conventional (monovalent) Fab of favezelimab and LAG3 (∼100 kDa) presented a challenge for cryoEM. Accordingly, we engineered a bivalent version of Fab favezelimab that doubled the size of the Fab-LAG3 complex and conferred a highly identifiable shape to the complex that facilitated particle selection and orientation for image processing. This study establishes bivalent Fabs as new fiducial markers for cryoEM analysis of small proteins.

项与 Favezelimab 相关的新闻（医药）

2026-03-23

·百奥赛图

最新嘉宾阵容｜百奥赛图BioX创新论坛 · 国际版：下一个十年的抗体疗法

会议背景在下一个十年的抗体疗法浪潮中，科学突破与跨国协作正成为驱动行业前行的核心引擎。如何从早期分子精准跨越至临床阶段？AI与创新平台如何进一步释放抗体多样性的潜力？跨国BD合作又将如何重塑全球医药资本与产业格局？ 2026年百奥赛图BioX创新论坛将于3月27日在上海盛大开启。本次论坛将汇聚来自全球生物医药企业、创新机构与投资领域的资深专家与行业同仁，共同交流前沿洞见，分享实践经验。论坛将聚焦T Cell Engagers (TCE)、mRNA递送、ADC等前沿赛道，围绕创新技术、产业协同与全球化发展趋势展开深入探讨，共同展望生物医药新纪元下的科学逻辑与商业未来。本次论坛采用报名审核制，席位有限，诚邀感兴趣的行业同仁一起交流！会议信息会议时间 2026年3月27日（周五）8:00-20:00 会议地点上海浦东（详细地址将在确认邮件中通知）会议规模上限100人，报名审核制会议最终解释权归百奥赛图所有会议日程 3月27日 08:00-08:50 会议签到 08:50-09:00 欢迎致辞沈月雷博士-百奥赛图，董事长兼CEO 09:00-09:30 Keynote 1: Development of Novel, CD8-guided, T Cell Engagers for the Treatment of Solid Tumors and Hematological Malignancies Saso Cemerski, Ph.D., AstraZeneca, Executive Director, Head of Immune Engagers 09:30-10:00 Keynote 2: Intranasal Delivery of mRNA for Immunity, Inflammation, and Neurodegeneration Bruce Turner, M.D., Ph.D., Xanadu Bio, Founder, CEO & Chairman 10:00-10:30 Keynote 3: Synthetic Interferons Demonstrate Potent Antiviral and Anti-Tumor Activity with the Potential for an Improved Safety Profile Wade Blair, Ph.D., IntegerBio, CSO 10:30-11:00 Keynote 4: From Capital to Collaboration: Investment and Company Building with China Yi Ding, Ph.D., RA Capital, BD Director 11:00-12:00 Panel 1: The Next Frontier of Innovative Therapeutics: From Early-Stage Molecules to Clinical Trials Benny Yang, Ph.D. (Moderator), Biocytogen, CSO Saso Cemerski, Ph.D., Bruce Turner, M.D., Ph.D., Wade Blair, Ph.D., Yi Ding, Ph.D. 12:00-13:00 午餐 13:00-13:30 Keynote 5: RenSuper Workstation: An AI-Driven Antibody Discovery Platform From Target to Antibody Leads in Clicks 沈月雷博士-百奥赛图，董事长兼CEO 13:30-14:00 Keynote 6: Discovery of Novel ADC DB-1317 and Novel DUP9 Payload 花海清博士-映恩生物，高级副总裁、药物发现负责人 14:00-14:30 Keynote 7: Translating Immunobiology to Medicine 刘勇军博士-小路生物&拓胜医药，创始人&董事长 14:30-15:00 Keynote 8: Accelerating Translation with Integrated Humanized Mouse Models and Pharmacology Platforms 刘瑜洁博士-百奥赛图，药理药效部总监 15:00-15:20 茶歇 15:20-16:20 Panel 1: 谁定义创新药的未来？-- MNC视角 Icy Niu（主持人），百奥赛图， Executive Director, Business & Global Marketing 祁昱博士，默沙东（MSD），全球业务拓展与授权总监方明博士，葛兰素史克（GSK），业务拓展高级总监李哲丰博士，礼来制药（Lilly），外部创新合作总监徐琳鑫雨博士，罗氏（Roche），对外合作部肿瘤领域搜寻与评估负责人沈蓉博士，辉瑞投资有限公司（Pfizer Investment），炎症与免疫领域搜寻与评估及中国本土项目负责人 16:20-17:20 Panel 2: 谁定义创新药的未来？-- 中国Biotech视角沈月雷博士（主持人），百奥赛图，董事长兼CEO 刘勇军博士，小路生物&拓胜医药，创始人&董事长江山博士，翰森制药集团有限公司，首席技术官王卓智博士，安博宁生命科技公司，首席科学官赵昊先生，君合律师事务所，合伙人 17:20-20:00 晚宴 & 酒会报名方式 ● 请扫描下方二维码填写报名表单，审核通过后，我们将在会前一周内发送确认邮件，并提供详细会议信息。期待您的加入，共谋行业创新发展，与变革者同行！报告及圆桌讨论嘉宾 Saso Cemerski, Ph.D. AstraZeneca, Executive Director, Head of Immune Engagers Saso joined AZ in May 2021 from CUE Biopharma where they served as VP and Head of Discovery and Translational Immunology developing the company’s early discovery pipeline and enabling the entry of the CUE-101 and CUE-102 into clinical phase I testing. Prior to CUE, Saso was a Principal Scientist at Merck Research Laboratories where they were involved in the development of several IO programs and their transitioning into the clinic, including anti-LAG-3 mAb MK-4280 (as the in vitro biology lead) and two STING agonists MK-1454 and MK-2118 (as the program co-lead). Saso has also held positions in BMS focusing on early discovery autoimmunity programs and in Xencor where they were part of the team that led the advancement of the XmAb5871 program into the clinic. Saso is a trained immunologist with experience across working on programs targeting different immune cell types in different disease indications using both biologics and small molecule approaches. During their academic career at Washington University in St. Louis. Bruce Turner, M.D., Ph.D. Xanadu Bio, Founder, CEO & Chairman Bruce Turner is the managing partner and chief investment officer of Madison Avenue Investors which is a private equity investment vehicle investing in healthcare companies. Currently, Dr. Turner is the CEO of Xanadu Bio and IsoBio, Inc. which are focused on the intranasal delivery of mRNA for immunity, inflammation, oncology, and neurodegeneration, and targeted multi-valent radiotherapeutics, respectively. Dr. Turner was previously a cofounder and chief strategy o icer of Immunome (NASD: IMNM) which is a targeted oncology company focusing on ADC’s and small molecules. Dr. Turner received his M.D., Ph.D. degrees from the University of Pennsylvania School of Medicine and completed his oncology training at Yale University School of Medicine. Wade Blair, Ph.D. IntegerBio, Chief Scientific Officer (CSO) Dr. Blair has 25 years of industry experience at multiple biopharma companies. During his career, Dr. Blair has led numerous drug discovery programs that progressed to clinical trials in infectious disease and oncology. He contributed to the discovery and/or development of six approved drugs, including the HIV capsid inhibitor lenacapavir (Yeztugo), the HIV attachment inhibitor fostemsavir (Rukobia), and the RSV mAb nirsevimab (Beyfortus). In addition, he led the development of a personalized cancer vaccine platform at Gritstone Bio. Dr. Blair currently serves as Chief Scientific Officer of IntegerBio where he oversees immune modulatory programs in virology and oncology. Yi Ding, Ph.D. RA Capital, BD Director Dr. Yi Ding is acting as BD director at RA Capital Swiftbridge, bridging Chinese biotech innovation into global development. She is passionate about identifying innovative healthcare opportunities and supporting their growth; or helping to connect emerging science with international capital and expertise. She holds a Ph.D. from Duke University and a bachelor’s degree from Peking University. Benny Yang, Ph.D. (Moderator) Biocytogen, Chief Scientific Officer (CSO) Dr. Yang graduated from Fudan University with a Master’s degree in Microbiology. He received his Ph.D. degree in Immunology from the University of Connecticut and completed his postdoctoral training at New York University School of Medicine in Dr. Dan Littman’s research group. Then Dr. Yang was recruited to the Medical University of South Carolina (MUSC) as a tenure-track Assistant Professor in the Department of Microbiology and Immunology. In 2016, he joined Biocytogen as the Chief Scientific Officer, where he leads the Institute for Biologics. Dr. Yang has been instrumental in spearheading antibody drug discovery and has overseen the development of dozens of therapeutic antibody-based drugs, successfully advancing multiple projects to IND and clinical stages. 沈月雷博士百奥赛图，董事长兼CEO 沈博士本科毕业于武汉大学病毒学及分子生物学系，先后获得中国食品药品检定研究院免疫学硕士学位、美国马萨诸塞大学医学院免疫学博士学位，并在 HHMI/纽约大学医学院 Dan Littman 实验室从事博士后研究，长期深耕免疫学、基因编辑、模式动物和抗体药物研发等领域，拥有近三十年创新药底层技术与转化研究经验。 2008 年，沈博士在美国创立百奥赛图（股票代码：688796.SH；02315.HK），并带领公司构建了从靶点发现、全人抗体规模化开发、体内药效验证到全球 IND 申报的完整技术体系，打造出“全人抗体库 × 靶点人源化小鼠库”的双引擎平台，使百奥赛图成长为国际化、平台型的新药研发关键伙伴。始终坚持以技术创新驱动全球合作，推动公司向“成为全球新药发源地”的愿景持续迈进。花海清博士映恩生物，高级副总裁、药物发现负责人花海清博士于2003年从清华大学生物系生物技术专业毕业，于2009年从苏黎世大学毕业，获得分子生物学博士学位。毕业后一直从事创新药物的研发和生产。在过去十五年的工作中，花博士主持和参与了多项创新药物的研发，推进10余个产品进入临床研究。刘勇军博士小路生物&拓胜医药，创始人&董事长刘勇军博士于1984年获白求恩医科大学医学学士学位，1989年获英国伯明翰大学医学院免疫学博士学位，随后在该校进行2年的博士后工作。1991年刘博士作为Senior Scientist加入跨国制药公司法国里昂先灵葆雅，2001年加入先灵葆雅旗下美国生物技术公司DNAX研究所担任Principal Staff Scientist。2002年被美国得克萨斯大学安德森癌症中心聘为Vivian L. Smith杰出讲席教授、免疫学系主任和癌症免疫研究中心创始主任。2011年被贝勒研究所聘为首席科学官和贝勒免疫研究所所长。2014年被阿斯利康旗下全球生物制药子公司Medimmune聘为首席科学官和全球研究负责人。2014年至2020年，担任赛诺菲全球研究负责人。2020年至2024年，担任信达生物制药集团总裁。在2025年，刘博士创办了苏州小路生物科技有限公司和合肥拓胜医药科技有限公司，担任董事长一职。刘博士拥有丰富的科研成果，在Nature、Science、Cell等顶尖学术期刊上共发表了超过260篇论文，总引用次数超过10万次，这些研究为免疫学和肿瘤学领域提供了多个关键的药物靶点。刘瑜洁博士百奥赛图，药理药效部总监刘瑜洁博士博士毕业于北京大学药学院，后赴美国伊利诺伊理工大学、西北大学担任高级研究员，专注攻克肿瘤纳米药物跨血脑屏障（BBB）递送系统与肺损伤机制研究等前沿课题。2020年加入百奥赛图后，历任SD、药效资源与产品部经理，现任药理药效部总监，全面负责Biomice CRO业务体系的建设与运营，主导构建了覆盖300+PDX模型的标准化药效资源数据库及智能化数据服务系统。擅长并承接过多项国内外创新药企在肿瘤抗体药药理药效、免疫重建肿瘤药效业务，并且在使用人源化小鼠在临床前抗体药物在跨血脑屏障研究，肿瘤研究、自身免疫疾病领域和PDX应用领域具有丰富的项目经验。 Icy Niu（Moderator）百奥赛图，执行总监 Icy Niu 负责百奥赛图抗体资产的全球合作与授权，推动基于 RenMice 平台的创新抗体实现商业化转化。加入百奥赛图之前，她长期从事抗体发现工作，与多家药企及生物技术公司合作，支持从靶点验证、抗体筛选到早期优化的研发项目，对抗体成药性及转化路径有深入理解。当前，她聚焦推动抗体资产的对外合作与落地转化，通过提供可直接用于开发的抗体分子，帮助合作伙伴更高效地启动并推进药物研发项目，缩短从靶点到候选分子的周期，降低早期研发不确定性。祁昱博士默沙东（MSD），全球业务拓展与授权总监祁昱是默沙东全球业务拓展与授权总监，负责中国地区临床PoC前资产的搜索和评估。她有超过10年的研发和商务拓展经验。她在德国乌尔姆大学获得了分子医学博士学位，研究兴趣主要集中在免疫学、皮肤纤维化和干细胞生物学。徐琳鑫雨博士罗氏（Roche），对外合作部肿瘤领域搜寻与评估负责人徐琳鑫雨博士是一位在临床开发、全球战略及业务发展领域拥有深厚资历的生物医药人才。自2025年7月起，她正式出任对外合作部搜寻与评估负责人。徐博士拥有同济大学医学院医学博士学位。在结束了眼科医生执业生涯后，她于 2016 年投身工业界加入信达生物，负责 PD-1 抑制剂及多款新分子实体 (NME) 在中国及全球的临床开发工作。 2020年加入罗氏后，徐博士深耕早期临床开发领域。2021年至2022年期间，凭借其多元化的能力，她转入对外合作部门，专注于搜寻与评估以及项目交易。此后，她前往瑞士巴塞尔总部任职15个月，以医学总监的角色领导全球临床项目。2023年回国后，她重点负责ADC领域的开发工作，并最终凭借其在临床与商业领域的复合专业经验，领导相关业务开展。方明博士葛兰素史克（GSK），业务拓展高级总监方明博士是葛兰素史克（GSK）业务拓展高级总监，负责在中国市场探寻许可及并购机会。在加入葛兰素史克之前，她担任默克医药（Merck Healthcare KGaA）全球业务拓展与许可事务总监，牵头开展外部创新引进工作，并促进与中国及亚太地区生物制药公司的合作。方明主导了多项与本土创新企业的许可合作项目以及多个研发和临床合作项目。在加入默克之前，方明担任科望医药（Elpiscience Biopharma）业务拓展负责人，领导业务拓展及战略工作。在此职位上，她促成了多笔许可交易及合作项目。她也曾在再鼎医药（Zailab）和诺华（Novartis）任职，专注于外部合作及肿瘤学研发工作。方明在巴黎居里研究所（Curie Institute）完成了博士阶段的学习，拥有法国巴黎皮埃尔和玛丽・居里大学（Université Pierre et Marie Curie）癌症生物学与遗传学专业的博士学位及硕士学位。李哲丰博士礼来制药（Lilly），外部创新合作总监李哲丰博士拥有十余年基因疗法与药物递送的研发经验，他从中山大学毕业后在俄亥俄州立大学接受博士训练，研究方向为小核酸递送。随后加入礼来制药（Eli Lilly and Company）作为礼来基因疗法部门(Lilly Genetic Medicine)的创始团队成员之一专注于核酸药物的递送创新研究。目前主要负责礼来在基因疗法外部创新以及中国创新合作中心的工作。沈蓉博士辉瑞投资有限公司（Pfizer Investment），炎症与免疫领域搜寻与评估及中国本土项目负责人沈蓉女士在医疗产业、投资及咨询领域拥有多年工作经验，现任炎症与免疫领域搜寻与评估及中国本土项目负责人。在加入辉瑞之前，她曾在晨兴创投等知名投资机构任职，从事创新药和新兴技术的投资，并于IQVIA等咨询公司任管理咨询顾问，为跨国药企和本土生物科技公司提供战略支持。沈蓉女士于中国科学技术大学获得化学专业学士学位，后于宾夕法尼亚大学获得生物化学博士学位。江山博士翰森制药集团有限公司，首席技术官前辉瑞生物制药副总裁, 曾经任职于Bayer, BMS,和Seagen的高级管理岗位。从业生物制药领域28年，拥有开发⽣物药的丰富经验。在美国江博曾成功领导多功能CMC 部门获得5款药物全球商业批准，领导并支持更多管线产品从临床前到市场的研发和生产。江博领导翰森制药生物药的开发和生产，管线包括单抗，多抗，融合蛋白，抗体-药物偶联（ADC）药物，负责项目从pre-IND⾄BLA的CMC 开发，供应链管理，以及产品的临床和商业化生产。王卓智博士安博宁生命科技公司，首席科学官安博宁联合创始人和首席科学官，专注于研发新一代TCE用于实体瘤治疗。前药明生物副总裁，领导组建新药研发服务部，管理120+人的新药研发团队, 在公司发展不同阶段负责技术创新、创新药项目立项和管理、临床前开发以及 IND申报。 2024年全球TCE授权记录CN201（CD19 TCE）的药明生物研发负责人，以13亿美元授权默沙东，首付款7亿美元。成功打造具有自主知识产权的WuXiBody® 和SDArBody™等抗体技术平台，以超过10亿美元的合约授权给20+个客户和合作伙伴。 25年生物制药经验，包括领导拜耳抗体工程团队，是抗体屏蔽和酶激活的最早发明人之一，领导多个管线从靶点到临床开发。北京大学肿瘤学博士；加州大学伯克利MBA。赵昊先生君合律师事务所，合伙人赵昊律师是君合律师事务所的合伙人。他具有医药和法学双重背景，并且在加入君合之前就职于恒瑞医药，熟悉药品的早期研发。赵昊律师不仅处理了大量的专利事务和知识产权尽调项目，并且主导了超过200项医药领域的技术交易。赵律师近年主导了百奥赛图跟Ideaya、Gilead、Neurocrine、ABL等交易、德琪和UCB、先声再明与Ipsen和NextCure、嘉和生物跟TRC2004的NewCo交易、宜明昂科跟Instil Bio的许可交易、宜联生物跟BioNtech的平台合作、科望和Astellas的产品+平台合作、嘉越和Erasca、祐森健恒与AZ、加科思和艾力斯、艺妙神州与华东医药等等交易。嘉宾排名不分先后关于百奥赛图百奥赛图（股票代码：688796.SH；02315.HK）是一家创新技术驱动新药研发的国际性生物技术公司，致力于成为全球新药发源地。公司以自主研发的基因编辑技术为核心，构建起“全人抗体分子库 + 靶点人源化小鼠库”的双引擎平台，系统性加速全球药物研发。百奥赛图自主开发了RenMice® 全人抗体平台（涵盖 RenMab®、RenLite®、RenNano®、RenTCR®、RenTCR mimic™），用于治疗性全人单抗、双/多特异性抗体、双抗ADC、纳米抗体以及类TCR抗体等的发现。围绕1000+潜在可成药靶点，公司正推进规模化抗体发现计划——“千鼠万抗™”，已构建超过100万条真实全人抗体序列库，并开放全球合作。截至2025年6月30日，百奥赛图已累计签署约280项药物合作开发 / 授权 / 转让协议。公司子品牌百奥动物已建立数千种基因编辑动物/细胞模型，拥有全球规模领先的靶点人源化小鼠库，并为全球客户提供临床前药理药效研究、基因编辑服务与模型构建等全链条能力支持。百奥赛图总部位于北京，并在中国（江苏海门、上海）、美国（波士顿、旧金山、圣地亚哥）及德国海德堡等地设有分支机构，形成面向全球的研发与运营网络。更多信息请访问官网：https://biocytogen.com.cn/

信使RNA抗体药物偶联物

2026-03-18

·百奥赛图

百奥赛图BioX创新论坛 · 国际版 | 下一个十年的抗体疗法：科学突破，跨国合作与资本逻辑

会议背景在下一个十年的抗体疗法浪潮中，科学突破与跨国协作正成为驱动行业前行的核心引擎。如何从早期分子精准跨越至临床阶段？AI与创新平台如何进一步释放抗体多样性的潜力？跨国BD合作又将如何重塑全球医药资本与产业格局？ 2026年百奥赛图BioX创新论坛将于3月27日在上海盛大开启。本次论坛将汇聚来自全球生物医药企业、创新机构与投资领域的资深专家与行业同仁，共同交流前沿洞见，分享实践经验。论坛将聚焦T Cell Engagers (TCE)、mRNA递送、ADC等前沿赛道，围绕创新技术、产业协同与全球化发展趋势展开深入探讨，共同展望生物医药新纪元下的科学逻辑与商业未来。本次论坛采用报名审核制，席位有限，诚邀感兴趣的行业同仁一起交流！会议信息会议时间 2026年3月27日（周五）8:00-20:00 会议地点上海浦东（详细地址将在确认邮件中通知）会议规模上限100人，报名审核制会议最终解释权归百奥赛图所有会议日程 3月27日 08:00-08:50 会议签到 08:50-09:00 欢迎致辞沈月雷博士-百奥赛图，董事长兼CEO 09:00-09:30 Keynote 1: Development of Novel, CD8-guided, T Cell Engagers for the Treatment of Solid Tumors and Hematological Malignancies Saso Cemerski, Ph.D., AstraZeneca, Executive Director, Head of Immune Engagers 09:30-10:00 Keynote 2: Intranasal Delivery of mRNA for Immunity, Inflammation, and Neurodegeneration Bruce Turner, M.D., Ph.D., Xanadu Bio, Founder, CEO & Chairman 10:00-10:30 Keynote 3: Synthetic Interferons Demonstrate Potent Antiviral and Anti-Tumor Activity with the Potential for an Improved Safety Profile Wade Blair, Ph.D., IntegerBio, CSO 10:30-11:00 Keynote 4: From Capital to Collaboration: Investment and Company Building with China Yi Ding, Ph.D., RA Capital, BD Director 11:00-12:00 Panel 1: The Next Frontier of Innovative Therapeutics: From Early-Stage Molecules to Clinical Trials Benny Yang, Ph.D. (Moderator), Biocytogen, CSO Saso Cemerski, Ph.D., Bruce Turner, M.D., Ph.D., Wade Blair, Ph.D., Yi Ding, Ph.D. 12:00-13:00 午餐 13:00-13:30 Keynote 5: RenSuper Workstation: An AI-Driven Antibody Discovery Platform From Target to Antibody Leads in Clicks 沈月雷博士-百奥赛图，董事长兼CEO 13:30-14:00 Keynote 6: Discovery of Novel ADC DB-1317 and Novel DUP9 Payload 花海清博士-映恩生物，高级副总裁、药物发现负责人 14:00-14:30 Keynote 7: Translating Immunobiology to Medicine 刘勇军博士-小路生物&拓胜医药，创始人&董事长 14:30-15:00 Keynote 8: Accelerating Translation with Integrated Humanized Mouse Models and Pharmacology Platforms 刘瑜洁博士-百奥赛图，药理药效部总监 15:00-15:20 茶歇 15:20-16:20 Panel 1: 谁定义创新药的未来？-- MNC视角 Icy Niu（主持人），百奥赛图， Executive Director, Business & Global Marketing 祁昱博士，默沙东（MSD），全球业务拓展与授权总监方明博士，葛兰素史克（GSK），业务拓展高级总监李哲丰博士，礼来制药（Lilly），外部创新合作总监徐琳鑫雨博士，罗氏（Roche），对外合作部肿瘤领域搜寻与评估负责人 TBD，辉瑞（Pfizer） 16:20-17:20 Panel 2: 谁定义创新药的未来？-- 中国Biotech视角沈月雷博士（主持人）花海清博士，刘勇军博士江山博士，翰森制药集团有限公司，首席技术官赵昊先生，君合律师事务所，合伙人 17:20-20:00 晚宴 & 酒会报名方式 ● 请扫描下方二维码填写报名表单，审核通过后，我们将在会前一周内发送确认邮件，并提供详细会议信息。期待您的加入，共谋行业创新发展，与变革者同行！报告及圆桌讨论嘉宾 Saso Cemerski, Ph.D. AstraZeneca, Executive Director, Head of Immune Engagers Saso joined AZ in May 2021 from CUE Biopharma where they served as VP and Head of Discovery and Translational Immunology developing the company’s early discovery pipeline and enabling the entry of the CUE-101 and CUE-102 into clinical phase I testing. Prior to CUE, Saso was a Principal Scientist at Merck Research Laboratories where they were involved in the development of several IO programs and their transitioning into the clinic, including anti-LAG-3 mAb MK-4280 (as the in vitro biology lead) and two STING agonists MK-1454 and MK-2118 (as the program co-lead). Saso has also held positions in BMS focusing on early discovery autoimmunity programs and in Xencor where they were part of the team that led the advancement of the XmAb5871 program into the clinic. Saso is a trained immunologist with experience across working on programs targeting different immune cell types in different disease indications using both biologics and small molecule approaches. During their academic career at Washington University in St. Louis. Bruce Turner, M.D., Ph.D. Xanadu Bio, Founder, CEO & Chairman Bruce Turner is the managing partner and chief investment officer of Madison Avenue Investors which is a private equity investment vehicle investing in healthcare companies. Currently, Dr. Turner is the CEO of Xanadu Bio and IsoBio, Inc. which are focused on the intranasal delivery of mRNA for immunity, inflammation, oncology, and neurodegeneration, and targeted multi-valent radiotherapeutics, respectively. Dr. Turner was previously a cofounder and chief strategy o icer of Immunome (NASD: IMNM) which is a targeted oncology company focusing on ADC’s and small molecules. Dr. Turner received his M.D., Ph.D. degrees from the University of Pennsylvania School of Medicine and completed his oncology training at Yale University School of Medicine. Wade Blair, Ph.D. IntegerBio, Chief Scientific Officer (CSO) Dr. Blair has 25 years of industry experience at multiple biopharma companies. During his career, Dr. Blair has led numerous drug discovery programs that progressed to clinical trials in infectious disease and oncology. He contributed to the discovery and/or development of six approved drugs, including the HIV capsid inhibitor lenacapavir (Yeztugo), the HIV attachment inhibitor fostemsavir (Rukobia), and the RSV mAb nirsevimab (Beyfortus). In addition, he led the development of a personalized cancer vaccine platform at Gritstone Bio. Dr. Blair currently serves as Chief Scientific Officer of IntegerBio where he oversees immune modulatory programs in virology and oncology. Yi Ding, Ph.D. RA Capital, BD Director Dr. Yi Ding is acting as BD director at RA Capital Swiftbridge, bridging Chinese biotech innovation into global development. She is passionate about identifying innovative healthcare opportunities and supporting their growth; or helping to connect emerging science with international capital and expertise. She holds a Ph.D. from Duke University and a bachelor’s degree from Peking University. Benny Yang, Ph.D. (Moderator) Biocytogen, Chief Scientific Officer (CSO) Dr. Yang graduated from Fudan University with a Master’s degree in Microbiology. He received his Ph.D. degree in Immunology from the University of Connecticut and completed his postdoctoral training at New York University School of Medicine in Dr. Dan Littman’s research group. Then Dr. Yang was recruited to the Medical University of South Carolina (MUSC) as a tenure-track Assistant Professor in the Department of Microbiology and Immunology. In 2016, he joined Biocytogen as the Chief Scientific Officer, where he leads the Institute for Biologics. Dr. Yang has been instrumental in spearheading antibody drug discovery and has overseen the development of dozens of therapeutic antibody-based drugs, successfully advancing multiple projects to IND and clinical stages. 沈月雷博士百奥赛图，董事长兼CEO 沈博士本科毕业于武汉大学病毒学及分子生物学系，先后获得中国食品药品检定研究院免疫学硕士学位、美国马萨诸塞大学医学院免疫学博士学位，并在 HHMI/纽约大学医学院 Dan Littman 实验室从事博士后研究，长期深耕免疫学、基因编辑、模式动物和抗体药物研发等领域，拥有近三十年创新药底层技术与转化研究经验。 2008 年，沈博士在美国创立百奥赛图（股票代码：688796.SH；02315.HK），并带领公司构建了从靶点发现、全人抗体规模化开发、体内药效验证到全球 IND 申报的完整技术体系，打造出“全人抗体库 × 靶点人源化小鼠库”的双引擎平台，使百奥赛图成长为国际化、平台型的新药研发关键伙伴。始终坚持以技术创新驱动全球合作，推动公司向“成为全球新药发源地”的愿景持续迈进。花海清博士映恩生物，高级副总裁、药物发现负责人花海清博士于2003年从清华大学生物系生物技术专业毕业，于2009年从苏黎世大学毕业，获得分子生物学博士学位。毕业后一直从事创新药物的研发和生产。在过去十五年的工作中，花博士主持和参与了多项创新药物的研发，推进10余个产品进入临床研究。刘勇军博士小路生物&拓胜医药，创始人&董事长刘勇军博士于1984年获白求恩医科大学医学学士学位，1989年获英国伯明翰大学医学院免疫学博士学位，随后在该校进行2年的博士后工作。1991年刘博士作为Senior Scientist加入跨国制药公司法国里昂先灵葆雅，2001年加入先灵葆雅旗下美国生物技术公司DNAX研究所担任Principal Staff Scientist。2002年被美国得克萨斯大学安德森癌症中心聘为Vivian L. Smith杰出讲席教授、免疫学系主任和癌症免疫研究中心创始主任。2011年被贝勒研究所聘为首席科学官和贝勒免疫研究所所长。2014年被阿斯利康旗下全球生物制药子公司Medimmune聘为首席科学官和全球研究负责人。2014年至2020年，担任赛诺菲全球研究负责人。2020年至2024年，担任信达生物制药集团总裁。在2025年，刘博士创办了苏州小路生物科技有限公司和合肥拓胜医药科技有限公司，担任董事长一职。刘博士拥有丰富的科研成果，在Nature、Science、Cell等顶尖学术期刊上共发表了超过260篇论文，总引用次数超过10万次，这些研究为免疫学和肿瘤学领域提供了多个关键的药物靶点。刘瑜洁博士百奥赛图，药理药效部总监刘瑜洁博士博士毕业于北京大学药学院，后赴美国伊利诺伊理工大学、西北大学担任高级研究员，专注攻克肿瘤纳米药物跨血脑屏障（BBB）递送系统与肺损伤机制研究等前沿课题。2020年加入百奥赛图后，历任SD、药效资源与产品部经理，现任药理药效部总监，全面负责Biomice CRO业务体系的建设与运营，主导构建了覆盖300+PDX模型的标准化药效资源数据库及智能化数据服务系统。擅长并承接过多项国内外创新药企在肿瘤抗体药药理药效、免疫重建肿瘤药效业务，并且在使用人源化小鼠在临床前抗体药物在跨血脑屏障研究，肿瘤研究、自身免疫疾病领域和PDX应用领域具有丰富的项目经验。 Icy Niu（Moderator）百奥赛图，执行总监 Icy Niu 负责百奥赛图抗体资产的全球合作与授权，推动基于 RenMice 平台的创新抗体实现商业化转化。加入百奥赛图之前，她长期从事抗体发现工作，与多家药企及生物技术公司合作，支持从靶点验证、抗体筛选到早期优化的研发项目，对抗体成药性及转化路径有深入理解。当前，她聚焦推动抗体资产的对外合作与落地转化，通过提供可直接用于开发的抗体分子，帮助合作伙伴更高效地启动并推进药物研发项目，缩短从靶点到候选分子的周期，降低早期研发不确定性。祁昱博士默沙东（MSD），全球业务拓展与授权总监祁昱是默沙东全球业务拓展与授权总监，负责中国地区临床PoC前资产的搜索和评估。她有超过10年的研发和商务拓展经验。她在德国乌尔姆大学获得了分子医学博士学位，研究兴趣主要集中在免疫学、皮肤纤维化和干细胞生物学。徐琳鑫雨博士罗氏（Roche），对外合作部肿瘤领域搜寻与评估负责人徐琳鑫雨（Tracy Xu）博士是一位在临床开发、全球战略及业务发展领域拥有深厚资历的生物医药人才。自2025年7月起，她正式出任对外合作部搜寻与评估负责人。徐博士拥有同济大学医学院医学博士学位。在结束了眼科医生执业生涯后，她于 2016 年投身工业界加入信达生物，负责 PD-1 抑制剂及多款新分子实体 (NME) 在中国及全球的临床开发工作。2020年加入罗氏后，徐博士深耕早期临床开发领域。2021年至2022年期间，凭借其多元化的能力，她转入对外合作部门，专注于搜寻与评估以及项目交易。此后，她前往瑞士巴塞尔总部任职15个月，以医学总监的角色领导全球临床项目。2023年回国后，她重点负责ADC领域的开发工作，并最终凭借其在临床与商业领域的复合专业经验，领导相关业务开展。方明博士葛兰素史克（GSK），业务拓展高级总监方明博士是葛兰素史克（GSK）业务拓展高级总监，负责在中国市场探寻许可及并购机会。在加入葛兰素史克之前，她担任默克医药（Merck Healthcare KGaA）全球业务拓展与许可事务总监，牵头开展外部创新引进工作，并促进与中国及亚太地区生物制药公司的合作。方明主导了多项与本土创新企业的许可合作项目以及多个研发和临床合作项目。在加入默克之前，方明担任科望医药（Elpiscience Biopharma）业务拓展负责人，领导业务拓展及战略工作。在此职位上，她促成了多笔许可交易及合作项目。她也曾在再鼎医药（Zailab）和诺华（Novartis）任职，专注于外部合作及肿瘤学研发工作。方明在巴黎居里研究所（Curie Institute）完成了博士阶段的学习，拥有法国巴黎皮埃尔和玛丽・居里大学（Université Pierre et Marie Curie）癌症生物学与遗传学专业的博士学位及硕士学位。李哲丰博士礼来制药（Lilly），外部创新合作总监李哲丰博士拥有十余年基因疗法与药物递送的研发经验，他从中山大学毕业后在俄亥俄州立大学接受博士训练，研究方向为小核酸递送。随后加入礼来制药（Eli Lilly and Company）作为礼来基因疗法部门(Lilly Genetic Medicine)的创始团队成员之一专注于核酸药物的递送创新研究。目前主要负责礼来在基因疗法外部创新以及中国创新合作中心的工作。江山博士翰森制药集团有限公司，首席技术官前辉瑞生物制药副总裁, 曾经任职于Bayer, BMS,和Seagen的高级管理岗位。从业生物制药领域28年，拥有开发⽣物药的丰富经验。在美国江博曾成功领导多功能CMC 部⻔获得5款药物全球商业批准，领导并支持更多管线产品从临床前到市场的研发和生产。江博领导翰森制药生物药的开发和生产，管线包括单抗，多抗，融合蛋白，抗体-药物偶联（ADC）药物，负责项目从pre-IND⾄BLA的CMC 开发，供应链管理，以及产品的临床和商业化生产。赵昊先生君合律师事务所，合伙人赵昊律师是君合律师事务所的合伙人。他具有医药和法学双重背景，并且在加入君合之前就职于恒瑞医药，熟悉药品的早期研发。赵昊律师不仅处理了大量的专利事务和知识产权尽调项目，并且主导了超过200项医药领域的技术交易。赵律师近年主导了百奥赛图跟Ideaya、Gilead、Neurocrine、ABL等交易、德琪和UCB、先声再明与Ipsen和NextCure、嘉和生物跟TRC2004的NewCo交易、宜明昂科跟Instil Bio的许可交易、宜联生物跟BioNtech的平台合作、科望和Astellas的产品+平台合作、嘉越和Erasca、祐森健恒与AZ、加科思和艾力斯、艺妙神州与华东医药等等交易。嘉宾排名不分先后关于百奥赛图百奥赛图（股票代码：688796.SH；02315.HK）是一家创新技术驱动新药研发的国际性生物技术公司，致力于成为全球新药发源地。公司以自主研发的基因编辑技术为核心，构建起“全人抗体分子库 + 靶点人源化小鼠库”的双引擎平台，系统性加速全球药物研发。百奥赛图自主开发了RenMice® 全人抗体平台（涵盖 RenMab®、RenLite®、RenNano®、RenTCR®、RenTCR mimic™），用于治疗性全人单抗、双/多特异性抗体、双抗ADC、纳米抗体以及类TCR抗体等的发现。围绕1000+潜在可成药靶点，公司正推进规模化抗体发现计划——“千鼠万抗™”，已构建超过100万条真实全人抗体序列库，并开放全球合作。截至2025年6月30日，百奥赛图已累计签署约280项药物合作开发 / 授权 / 转让协议。公司子品牌百奥动物已建立数千种基因编辑动物/细胞模型，拥有全球规模领先的靶点人源化小鼠库，并为全球客户提供临床前药理药效研究、基因编辑服务与模型构建等全链条能力支持。百奥赛图总部位于北京，并在中国（江苏海门、上海）、美国（波士顿、旧金山、圣地亚哥）及德国海德堡等地设有分支机构，形成面向全球的研发与运营网络。更多信息请访问官网：https://biocytogen.com.cn/

信使RNA抗体药物偶联物

2026-03-13

·EndPoints

A LAG-3 pioneer fails in Phase 3, pouring more cold water on a once-hot cancer target

A few years ago, the oncology world wondered if it had found its next big breakthrough: a third major checkpoint inhibitor beyond PD-1 and CTLA-4. The FDA in 2022 approved Bristol Myers Squibb’s LAG-3-targeting Opdualag. Many drugmakers hoped that would be the start of a new class of cancer immunotherapy. But there have been few positive updates in the LAG-3 world since then. A tiny Australian biotech added to the list of failures on Friday. Immutep said its lead LAG-3 drug candidate flunked an interim futility analysis for a Phase 3 lung cancer study, triggering plans to wind down the trial. Immutep’s drug, eftilagimod alfa (or efti for short), is a LAG-3 fusion protein designed to help the body’s immune system fight cancer. The company did not disclose detailed results on Friday, but the press release and subsequent market reaction suggest there may not be many silver linings. Its stock, trading on the Australian market, fell over 80%, leaving the company valued at less than $100 million. “We are very disappointed and surprised with the outcome of the futility analysis, in light of efti’s performance in every other clinical trial,” Immutep CEO Marc Voigt said in a statement. Immutep has been a pioneer in LAG-3. Frédéric Triebel, a French immunologist who discovered the LAG-3 receptor in 1990, founded the company in 2001. Triebel is still leading Immutep as its chief scientific officer. The study, called TACTI-004, was efti’s first Phase 3 trial. There are several ongoing mid-stage studies for the drug, but Immutep’s release did not comment on the future of those studies or the drug program more broadly. Opdualag remains the only FDA-approved treatment targeting LAG-3. While Bristol Myers earned a melanoma approval in 2022, the company has faced clinical setbacks in expanding into other indications, including coming up short in lung and colon cancer. Other major drugmakers have cooled on LAG-3. Merck abandoned its own LAG-3 inhibitor favezelimab in 2024, following underwhelming Phase 3 data in colon cancer and classical Hodgkin lymphoma. Immutep’s failure comes ahead of a highly anticipated readout from Regeneron on its LAG-3 inhibitor called fianlimab. Regeneron expects a pivotal readout in first-line melanoma in the first half of 2026. The New York biopharma is also running a head-to-head melanoma study that pits a combination of fianlimab and its own PD-1 inhibitor Libtayo against Opdualag.

临床3期免疫疗法

100 项与 Favezelimab 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
实体瘤	临床3期	美国	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	中国	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	日本	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	阿根廷	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	澳大利亚	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	奥地利	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	比利时	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	巴西	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	加拿大	Merck Sharp & Dohme Corp.	2018-08-21
实体瘤	临床3期	智利	Merck Sharp & Dohme Corp.	2018-08-21

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03598608 (ASCO2024) 人工标引	临床1/2期	难治性经典霍奇金淋巴瘤	34	Favezelimab + Pembrolizumab	範選膚選積製鏇鹹範範(鬱選膚鹽願襯積願簾鏇) = 網襯齋範獵糧鑰齋齋繭鹹簾淵遞夢廠衊餘構觸 (憲壓膚構醖鬱餘構糧簾 ) 更多	积极	2024-05-24
NCT03598608 (ASCO2024) 人工标引	临床1/2期	难治性经典霍奇金淋巴瘤	34	Favezelimab + Pembrolizumab (With anti–PD-1 as most recent therapy)	築醖築繭廠憲淵獵窪膚(憲鏇鏇鹽憲築淵衊遞製) = 糧夢鬱廠鹹構鹽製廠醖鏇積廠蓋顧簾醖遞襯壓 (製醖醖範窪遞齋醖簾簾, 14 ~ 62)	积极	2024-05-24
NCT03598608 (ASCO2024)	临床1/2期	复发性经典霍奇金淋巴瘤 LAG-3	30	Pembrolizumab 200 mg IV Q3W plus favezelimab 200-mg starting dose	獵鬱積築夢淵餘鏇願窪(簾夢獵遞鹹艱夢繭憲願) = 製壓醖構衊積鬱選遞遞選艱觸鏇鹹齋簾艱窪糧 (簾鑰襯網壓憲淵廠齋鑰, 65 ~ 94) 更多	积极	2024-05-24
NCT03598608 (MK-4280-003, EHA2024)	临床1/2期	难治性惰性非霍奇金淋巴瘤	24	Favezelimab plus Pembrolizumab	鬱網淵獵築窪繭淵鹽壓(繭遞範糧齋製醖齋築蓋) = 築糧鬱壓製廠淵鹽觸窪艱壓壓夢構齋顧觸齋簾 (淵範獵鬱鏇壓壓遞鑰製, 8 ~ 44) 更多	积极	2024-05-14
NCT03598608 (4280-003 \| MK-4280-003, ASH2023)	临床1/2期	难治性经典霍奇金淋巴瘤	34	Favezelimab + Pembrolizumab	淵夢糧簾壓繭醖艱網廠(襯憲積膚膚齋膚廠鏇觸) = 淵鹽蓋窪夢膚製廠築鬱簾鑰醖鏇餘積構鏇蓋鬱 (鹽襯壓獵遞蓋鑰範築夢, 15 ~ 48) 更多	-	2023-12-11
NCT03598608 (4280-003 \| MK-4280-003, ASH2023)	临床1/2期	复发性弥漫性大B细胞淋巴瘤	25	Favezelimab 800 mg	顧糧鹹遞餘製糧築艱淵(簾憲範構齋選繭網鹽顧) = 醖糧窪廠艱糧鹹壓夢簾鹹願淵壓製鏇壓憲襯築 (襯獵夢齋觸齋夢齋築蓋, 2.5 ~ 31.2) 更多	-	2023-12-09
NCT03598608 (4280-003 \| MK-4280-003 \| Phase 1/2 Study, ASH2023)	临床1/2期	难治性经典霍奇金淋巴瘤	30	Favezelimab 800 mg + Pembrolizumab 200 mg	範鹹網壓選鑰廠艱憲範(顧鏇醖憲衊範築淵憲觸) = 網艱獵網選網觸壓繭鏇蓋壓鑰膚願製壓膚襯齋 (範夢齋糧選鏇齋壓襯鑰, 61 ~ 92) 更多	-	2023-12-09
NCT03598608 (MK-4280-003, ICML2023)	临床1/2期	霍奇金淋巴瘤 \| 血液肿瘤 \| B细胞淋巴瘤 ... anti-PD-1-refractory 更多	33	Favezelimab + Pembrolizumab	顧繭餘繭鹹襯艱構鹹願(淵壓窪範襯繭衊艱構襯) = 構壓鹽製築積襯夢網築淵齋衊顧積築遞憲鹹獵 (淵繭壓遞鹽築蓋網廠蓋, 15 ~ 51)	积极	2023-06-09
NCT03598608 (MK-4280-003, ICML2023)	临床1/2期	霍奇金淋巴瘤 \| 血液肿瘤 \| B细胞淋巴瘤 ... anti-PD-1-refractory 更多	33	Pembrolizumab	顧繭餘繭鹹襯艱構鹹願(淵壓窪範襯繭衊艱構襯) = 衊醖壓鹹蓋夢簾鏇獵築淵齋衊顧積築遞憲鹹獵 (淵繭壓遞鹽築蓋網廠蓋, 0 ~ 5.9)	积极	2023-06-09
NCT03598608 (ICML2023)	临床1/2期	复发性经典霍奇金淋巴瘤 anti-PD-1	-	Favezelimab plus Pembrolizumab	構襯窪鬱築鑰蓋蓋網夢(淵獵鹽網淵襯簾鹽醖淵) = 構壓築齋衊鹹鹽衊構簾壓艱鏇願遞鬱襯築憲顧 (獵壓鏇簾窪壓窪鬱願構 ) 更多	积极	2023-06-09
NCT03598608 (4280-003 \| MK-4280-003, EHA2023)	临床1/2期	霍奇金淋巴瘤 \| 血液肿瘤 \| B细胞淋巴瘤	34	Favezelimab + Pembrolizumab	襯衊鹽範淵鏇製餘襯淵(餘鏇壓齋遞顧衊壓鑰壓) = 鹽繭艱餘遞淵襯網選鑰窪襯艱繭鹹憲鏇齋觸顧 (願蓋衊餘遞鹽鹹壓壓積, 15 ~ 48) 更多	-	2023-06-08
NCT03598608 (4280-003 \| MK-4280-003, EHA2023)	临床1/2期	霍奇金淋巴瘤 \| B细胞淋巴瘤 \| 血液肿瘤	-	Favezelimab + Pembrolizumab	觸觸範鬱願顧膚壓衊構(製鹹夢範蓋夢淵顧選簾) = 積窪醖淵齋願顧鏇餘鑰構鹽窪築衊鏇艱獵網願 (鏇積鏇繭簾窪齋構鑰糧, 61 ~ 92) 更多	-	2023-06-08