Navivumab(Navivumab) - 药物靶点：hemagglutinin_在研适应症：甲型流感病毒感染_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名

+ [1]

靶点

hemagglutinin

作用机制

hemagglutinin调节剂(血凝素调节剂)

治疗领域

感染呼吸系统疾病

在研适应症

甲型流感病毒感染

非在研适应症-

原研机构

Celltrion, Inc.

在研机构

Yonsei University Health System

Centers for Disease Control & Prevention

非在研机构

Celltrion, Inc.

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 9053374L

来源: *****

Sequence Code 316784540H

来源: *****

关联

5

项与 Navivumab 相关的临床试验

KCT0002211

/ Recruiting临床2期

A Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled Study Evaluating the Efficacy and Safety of CT-P27 in Subjects with Acute Uncomplicated Influenza A Infection

开始日期2016-12-09

申办/合作机构

Celltrion, Inc.

NCT03511066

/ Terminated临床2期

A Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled Study Evaluating the Efficacy and Safety of CT-P27 in Subjects With Acute Uncomplicated Influenza A Infection

This study is a Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled study evaluating the efficacy and safety of CT-P27 in subjects with acute uncomplicated influenza A infection.

开始日期2016-12-09

申办/合作机构

Celltrion, Inc.

NCT02071914

/ Completed临床2期

A Randomised, Double-Blind, Placebo-Controlled, Single-Centre, Phase IIa Study in Healthy Volunteers to Evaluate the Efficacy and Safety of CT-P27 in an Influenza Challenge Model

This study is to evaluate the efficacy of CT-P27 measured by quantitative PCR viral load from nasopharyngeal mucosa, compared to placebo.

开始日期2014-02-15

申办/合作机构

Celltrion, Inc.

100 项与 Navivumab 相关的临床结果

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100 项与 Navivumab 相关的转化医学

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100 项与 Navivumab 相关的专利（医药）

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1

项与 Navivumab 相关的文献（医药）

PLOS ONE3区 · 综合性期刊

Broader neutralization of CT-P27 against influenza A subtypes by combining two human monoclonal antibodies

3区 · 综合性期刊

ArticleOA

作者: Ryu, Dong-Kyun ; Shin, JiYoung ; Lee, Soo-Young ; Choi, Jung-Ah ; Yi, Kye Sook ; Lee, Sena ; Lee, Eun Beom ; Son, Dain ; Chae, Ji-Sang ; Song, Manki ; Yang, Eunji ; Kim, Pankyeom ; Im, Bok-Hyeon ; Park, Hayan ; Lee, HyunJoo

There are several broadly neutralizing monoclonal antibodies that neutralize influenza viruses with different mechanisms from traditional polyclonal antibodies induced by vaccination. CT149, which is one of the broadly neutralizing antibodies, was also previously reported to neutralize group 2 and some of group 1 influenza viruses (13 out of 13 tested group 2 viruses and 5 out of 11 group 1 viruses). In this study, we developed another antibody with the aim of compensating partial coverage of CT149 against group 1 influenza viruses. CT120 was screened among different antibody candidates and mixed with CT149. Importantly, although the binding sites of CT120 and CT149 are close to each other, the two antibodies do not interfere. The mixture of CT120 and CT149, which we named as CT-P27, showed broad efficacy by neutralizing 37 viruses from 11 different subtypes, of both group 1 and 2 influenza A viruses. Moreover, CT-P27 showed in vivo therapeutic efficacy, long prophylactic potency, and synergistic effect with oseltamivir in influenza virus-challenged mouse models. Our findings provide a novel therapeutic opportunity for more efficient treatment of influenza.

100 项与 Navivumab 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
甲型流感病毒感染	临床2期	-	Centers for Disease Control & Prevention	-
甲型流感病毒感染	临床2期	-	Yonsei University Health System	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03511066 (CTgov)	临床2期	甲型流感病毒感染	228	CT-P27 90 mg/kg (CT-P27 90 mg/kg)	鹹衊廠積壓選鑰構鏇網(簾蓋顧齋範襯觸窪膚壓) = 範壓鹽壓糧壓廠顧蓋範艱糧鹹網構顧鏇構獵醖 (製鑰積鏇壓夢鏇製遞壓, 齋齋顧遞觸窪艱構廠糧 ~ 壓觸壓構鹹範蓋簾淵鏇) 更多	-	2022-10-31
				CT-P27 45 mg/kg (CT-P27 45mg/kg)	鹹衊廠積壓選鑰構鏇網(簾蓋顧齋範襯觸窪膚壓) = 鹹範夢選鹽積鬱衊鹽鹹艱糧鹹網構顧鏇構獵醖 (製鑰積鏇壓夢鏇製遞壓, 鹽憲簾蓋衊鏇築鹹鬱膚 ~ 艱製積憲餘齋憲衊觸窪) 更多
NCT02071914 (CTgov)	临床2期	甲型流感病毒感染	81	CT-P27 (CT-P27 10mg/kg)	網醖選構簾醖鑰選淵鬱(壓鬱壓廠餘築壓鹽鏇遞) = 觸鏇廠淵夢膚簾夢鏇壓餘憲糧衊衊鬱製憲簾壓 (膚鑰艱夢艱廠簾窪網淵, 膚憲製遞蓋獵鑰憲襯廠 ~ 遞製壓艱襯遞鹹簾膚觸) 更多	-	2020-03-16
				CT-P27 (CT-P27 20mg/kg)	網醖選構簾醖鑰選淵鬱(壓鬱壓廠餘築壓鹽鏇遞) = 齋膚鹽糧簾壓襯築鹽鬱餘憲糧衊衊鬱製憲簾壓 (膚鑰艱夢艱廠簾窪網淵, 淵衊蓋繭衊鹽製窪網醖 ~ 鑰簾廠觸膚夢鑰廠繭簾) 更多