Navivumab(Navivumab) - 药物靶点：hemagglutinin_在研适应症：甲型流感病毒感染_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名

+ [1]

靶点

hemagglutinin

作用方式

调节剂

作用机制

hemagglutinin调节剂(血凝素调节剂)

治疗领域

感染呼吸系统疾病

在研适应症

甲型流感病毒感染

非在研适应症-

原研机构

Celltrion, Inc.

在研机构

Yonsei University Health System

Centers for Disease Control & Prevention

非在研机构

Celltrion, Inc.

权益机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 9053374L

来源: *****

Sequence Code 316784540H

来源: *****

关联

5

项与 Navivumab 相关的临床试验

NCT03511066

/ Terminated临床2期

A Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled Study Evaluating the Efficacy and Safety of CT-P27 in Subjects With Acute Uncomplicated Influenza A Infection

This study is a Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled study evaluating the efficacy and safety of CT-P27 in subjects with acute uncomplicated influenza A infection.

开始日期2016-12-09

申办/合作机构

Celltrion, Inc.

KCT0002211

/ Recruiting临床2期

A Phase IIb, Randomized, Double-blind, Multicenter, Placebo-controlled Study Evaluating the Efficacy and Safety of CT-P27 in Subjects with Acute Uncomplicated Influenza A Infection

开始日期2016-12-09

申办/合作机构

Celltrion, Inc.

NCT02071914

/ Completed临床2期

A Randomised, Double-Blind, Placebo-Controlled, Single-Centre, Phase IIa Study in Healthy Volunteers to Evaluate the Efficacy and Safety of CT-P27 in an Influenza Challenge Model

This study is to evaluate the efficacy of CT-P27 measured by quantitative PCR viral load from nasopharyngeal mucosa, compared to placebo.

开始日期2014-02-15

申办/合作机构

Celltrion, Inc.

100 项与 Navivumab 相关的临床结果

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100 项与 Navivumab 相关的转化医学

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100 项与 Navivumab 相关的专利（医药）

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1

项与 Navivumab 相关的文献（医药）

PLOS ONE3区 · 综合性期刊

Broader neutralization of CT-P27 against influenza A subtypes by combining two human monoclonal antibodies

3区 · 综合性期刊

ArticleOA

作者: Ryu, Dong-Kyun ; Shin, JiYoung ; Lee, Soo-Young ; Choi, Jung-Ah ; Yi, Kye Sook ; Lee, Sena ; Lee, Eun Beom ; Son, Dain ; Chae, Ji-Sang ; Song, Manki ; Yang, Eunji ; Im, Bok-Hyeon ; Kim, Pankyeom ; Park, Hayan ; Lee, HyunJoo

There are several broadly neutralizing monoclonal antibodies that neutralize influenza viruses with different mechanisms from traditional polyclonal antibodies induced by vaccination. CT149, which is one of the broadly neutralizing antibodies, was also previously reported to neutralize group 2 and some of group 1 influenza viruses (13 out of 13 tested group 2 viruses and 5 out of 11 group 1 viruses). In this study, we developed another antibody with the aim of compensating partial coverage of CT149 against group 1 influenza viruses. CT120 was screened among different antibody candidates and mixed with CT149. Importantly, although the binding sites of CT120 and CT149 are close to each other, the two antibodies do not interfere. The mixture of CT120 and CT149, which we named as CT-P27, showed broad efficacy by neutralizing 37 viruses from 11 different subtypes, of both group 1 and 2 influenza A viruses. Moreover, CT-P27 showed in vivo therapeutic efficacy, long prophylactic potency, and synergistic effect with oseltamivir in influenza virus-challenged mouse models. Our findings provide a novel therapeutic opportunity for more efficient treatment of influenza.

100 项与 Navivumab 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
甲型流感病毒感染	临床2期	-	Centers for Disease Control & Prevention	-
甲型流感病毒感染	临床2期	-	Yonsei University Health System	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03511066 (CTgov)	临床2期	甲型流感病毒感染	228	CT-P27 90 mg/kg (CT-P27 90 mg/kg)	蓋積壓窪餘廠觸窪積鹽(範鑰範鬱壓鹹遞鬱憲醖) = 鹹蓋艱獵衊簾鑰淵鬱積膚鏇網遞膚製夢鏇網衊 (鹹膚簾鬱糧構齋廠艱鬱, 鬱鑰鏇簾範窪膚艱襯獵 ~ 築餘醖遞艱繭衊壓窪壓) 更多	-	2022-10-31
				CT-P27 45 mg/kg (CT-P27 45mg/kg)	蓋積壓窪餘廠觸窪積鹽(範鑰範鬱壓鹹遞鬱憲醖) = 窪製觸願鑰網遞衊衊廠膚鏇網遞膚製夢鏇網衊 (鹹膚簾鬱糧構齋廠艱鬱, 願範醖艱鬱積構獵製築 ~ 襯網網廠鬱壓鏇餘觸遞) 更多
NCT02071914 (CTgov)	临床2期	甲型流感病毒感染	81	CT-P27 (CT-P27 10mg/kg)	壓簾齋淵餘積餘獵窪憲(齋獵顧鬱構壓觸鬱鑰襯) = 網鹹壓憲鬱艱範蓋窪製鏇廠鑰壓顧鹹鬱製遞積 (糧糧襯膚醖膚鬱膚網襯, 醖淵築鬱築廠鹽鑰餘觸 ~ 積窪觸簾築鑰衊願淵淵) 更多	-	2020-03-16
				CT-P27 (CT-P27 20mg/kg)	壓簾齋淵餘積餘獵窪憲(齋獵顧鬱構壓觸鬱鑰襯) = 構膚製憲築製鑰鹹顧範鏇廠鑰壓顧鹹鬱製遞積 (糧糧襯膚醖膚鬱膚網襯, 網鬱鏇獵餘淵遞夢糧簾 ~ 獵齋遞獵壓構簾鹽醖淵) 更多