BMS-984923

Safety of ALX-001 Reinforced by New Data Presented at AD/PD™ 2024 Conference in Lisbon Two Oral Doses Selected for Further Study in Alzheimer’s and Parkinson’s Disease Patients NEW HAVEN, Conn., March 11, 2024 (GLOBE NEWSWIRE) -- Allyx Therapeutics, a clinical-stage biotechnology company, announced that its lead compound, ALX-001, is ready to proceed to Phase 2 clinical development in Alzheimer’s and Parkinson’s disease. This announcement was made in conjunction with the presentation of positive findings from the company’s Phase 1b multiple ascending dose study at the AD/PD™ 2024 Conference in Lisbon. ALX-001 is a highly selective, first-in-class, synapse-targeted, disease-modifying oral therapy in development for neurodegenerative diseases. The multiple ascending dose study (NCT05804383) examined the safety, tolerability and pharmacokinetics of twice-daily oral doses of ALX-001 in 32 heathy adult participants aged 50-80. Study results show that ALX-001 was safe in cognitively normal older adults at all tested doses. ALX-001 achieved high exposure and successfully characterized a wide safety window at all doses, which ranged from 50mg to 150mg. Two doses were identified for future studies: 50mg and 100mg. All doses were well-tolerated and there were no serious adverse events. “The data show that ALX-001 achieved high target engagement without any adverse events related to mGluR5, which supports our vision to mediate synaptic dysfunction and loss while avoiding the on-target toxicity observed with other treatment modalities,” commented Stephen Strittmatter, M.D., Ph.D., scientific founder of Allyx Therapeutics and professor and chair of Neuroscience at the Yale University School of Medicine. Building on twelve years of clinical research, ALX-001 continues to demonstrate promise in ongoing studies. Allyx Therapeutics has initiated a 28-day safety study of ALX-001 in Alzheimer’s disease patients (NCT05804383) and is initiating a study in Parkinson’s disease patients. “We are excited to begin the next phase of development with the initiation of two 28-day patient studies, the first studies of ALX-001 in people living with Alzheimer’s and Parkinson’s disease,” commented Tim Siegert, Ph.D., chief operating officer and co-founder of Allyx Therapeutics. “We believe that the results from the Phase 1b MAD study directly support larger scale Phase 2 clinical development to more fully understand the potential for ALX-001 to become the first-ever disease-modifying small molecule for neurodegenerative diseases.” The ALX-001 program has received more than $20 million in grant funding from the National Institutes of Health, the U.S. Government’s highly competitive Small Business Innovation Research (SBIR) programs, the Alzheimer’s Association, and The Michael J. Fox Foundation for Parkinson’s Research, among others. In addition to Allyx’s continued clinical development of ALX-001 in Alzheimer’s disease, the company has announced an expansion into Parkinson’s disease clinical research with the opening of an Investigational New Drug Application with the U.S. Food and Drug Administration (FDA). About ALX-001 ALX-001 (previously BMS-984923) is a silent allosteric modulator of mGluR5, and is a first-in-class compound that selectively blocks the pathogenic activation of the receptor while preserving the normal physiological glutamate signaling that is required for cognition. As such, ALX-001 has a wide therapeutic window that can saturate receptors while avoiding on-target toxicity observed with negative allosteric modulators. mGluR5 has been shown to be essential for mediating synaptic dysfunction and loss caused by multiple misfolded extracellular protein species, and as such, presents a novel approach for treating Alzheimer's and Parkinson’s disease. Importantly, ALX-001 is an orally bioavailable and brain penetrant small molecule with demonstrated mGluR5 selective engagement. The molecule was originally identified by Bristol Myers Squibb, but the mechanism of action for neurodegenerative diseases and the identification of ALX-001 as disease-modifying for Alzheimer’s disease was discovered by Allyx scientific founder Stephen Strittmatter at Yale. Allyx Therapeutics obtained an exclusive worldwide license for ALX-001 from Bristol Myers Squibb and Yale University. About Allyx Therapeutics Allyx Therapeutics was founded in 2019 by a group of seasoned biopharma industry executives, venture capitalists, and scientific experts. The company aims to deliver a novel approach to preserve and protect synapses for people living with neurodegenerative diseases. Its lead compound, ALX-001, is a first-in-class oral therapy with a unique mechanism of action at mGluR5 in clinical development for Alzheimer’s disease and Parkinson’s disease. Learn more at allyxthera.com. Contact Media: Eliza Schleifstein917.763.8106Eliza@schleifsteinpr.com Investors: Tim Siegert203-691-6543tsiegert@allyxthera.com

▎药明康德内容团队编辑本期看点1. 诺和诺德（Novo Nordisk）的下一代减重疗法amycretin的1期临床试验结果亮眼，患者在接受治疗12周后体重下降幅度达13.1%。2. 用于治疗复发性和难治性恶性胶质瘤的CAR-T细胞疗法MB-101在1期临床试验中使50%的患者有获益，两名患者获得了完全缓解（CR），其中一名已维持超过66个月。3. 用于治疗1型强直性肌营养不良（DM1）的抗体偶联RNAi疗法del-desiran在早期临床试验中获得了积极的长期数据，与自然疾病历史数据相比，在多个临床终点逆转了患者的疾病进展。4. 拜耳（Bayer）用于治疗帕金森病的干细胞疗法BRT-DA01在1期临床研究中继续保持了良好的耐受性，且患者获益随时间继续增长。5. 治疗杜氏肌营养不良（DMD）的基因疗法RGX-202的早期临床试验的额外中期安全性和有效性数据积极，将于今年启动关键试验。药明康德内容团队整理Amycretin：公布1期临床试验数据诺和诺德公布了其口服GLP-1和胰淀素的长效共激动剂amycretin的最新临床试验结果。在这项包含16位患者的小型1期试验当中，患者在接受治疗12周后其体重下降幅度达13.1%，相较之下，安慰剂组患者的体重下降幅度仅为1.1%。此外，amycretin展现良好的药代动力学特性，以及与诺和诺德所开发的GLP-1类疗法类似的良好安全性、耐受性以及不良反应。行业媒体Fierce Biotech指出，过去STEP-1临床试验结果显示，司美格鲁肽组患者在68周试验期间的体重降幅为14.9%。虽然不同临床试验之间的结果难以一同比较，然而amycretin在1期试验早期结果中所展现快速减重的效果，展现了该药物的巨大潜力。▲口服amycretin在1期试验当中展现显著减重效果（图片来源：诺和诺德公司官网）该公司预计在2024年下半年启动2期试验，在2型糖尿病患者中探索口服与皮下注射amycretin的疗效与安全性。MB-101：公布1期临床试验数据Mustang Bio公司宣布，其CAR-T细胞疗法MB-101在治疗复发性和难治性恶性胶质瘤（包括胶质母细胞瘤）患者方面具有良好的安全性和临床活性。MB-101是一种靶向IL13Rα2的CAR-T细胞疗法，IL13Rα2是一种局限在GBM中表达的受体，在大多数多形性胶质母细胞瘤（GBM）中大量表达。MB-101包括铰链优化的第二代CAR，其IgG4接头中的突变可以减少脱靶Fc相互作用、4-1BB（CD137）共刺激信号结构域可以提高CAR-T细胞的持久性。它同时表达CD19的细胞外结构域作为筛选/安全标记。此次公布的结果显示，MB-101的耐受性良好，50%（29/58）的患者达到了疾病稳定（SD）或更好的状况，两位患者达到了部分缓解（PR），两位患者达到了CR。两位达到CR的患者分别维持了7.5个月和超过66个月。复发性GBM患者的的预期生存期为6个月，该研究中所有患者的中位总生存期（OS）为8个月，而接受肿瘤内（ICT）/脑室内（ICV）双重给药和优化制造工艺的MB-101治疗的复发性GBM患者的中位OS为10.2个月，较此类患者的预期生存期延长了70%，。Del-desiran（AOC 1001）：公布1/2期临床试验的长期数据Avidity Biosciences公司公布了其抗体偶联RNAi疗法del-desiran（曾用名AOC 1001）治疗1型强直性肌营养不良患者的开放标签扩展试验MARINA-OLE的最新积极长期数据。Del-desiran由Avidity专有的靶向1型转铁蛋白受体（TfR1）单克隆抗体与靶向DMPK基因mRNA的siRNA偶联所构成。临床前研究显示，它能够成功递送siRNA至肌肉组织，在骨骼肌、心肌与平滑肌等组织中引起持续性、剂量依赖性DMPK的mRNA水平下降。美国FDA与欧洲药品管理局（EMA）皆授予其孤儿药资格，FDA还授予此疗法快速通道资格。DM1是一种未被充分认识、逐渐恶化且常常致命的神经肌肉疾病，目前没有获批的治疗方法。此次公布的数据显示，与匹配的自然病史研究人群相比，接受del-desiran治疗的DM1患者一年内在多个终点上逆转了疾病的进展，包括肌张力、肌肉力量和患者报告的日常生活活动。该公司计划在今年第二季度启动3期临床试验HARBOR，▲Del-desiran显著改善vHOT临床终点（图片来源：Avidity Biosciences公司官网）▲Del-desiran显著改善手握力和定量肌肉测试指标（图片来源：Avidity Biosciences公司官网）Bemdaneprocel（BRT-DA01）：公布1期临床试验的新数据拜耳及其旗下BlueRock Therapeutics公司公布了其在研干细胞衍生疗法bemdaneprocel（BRT-DA01）治疗帕金森病的1期临床试验的新数据。Bemdaneprocel是一种在研细胞疗法，由多能干细胞衍生、可产生多巴胺的神经元组成，可通过手术植入帕金森病患者的大脑。当这些细胞被移植后，它们有可能重建帕金森病患者脑内受破坏的神经网络，借此恢复患者的运动和非运动功能。该研究使用Hauser Diary对患者进行分类，患者在“开通”（on）状态表示症状得到良好控制；在“关闭”（off）状态则表示症状恶化。此前公布的结果显示，和基线相比，参与bemdaneprocel临床试验的高剂量组受试者在一年后处于“开通”状态的时间多2.16小时，且没有出现运动障碍；处于“关闭”状态的时间相应减少了1.91小时。低剂量组受试者处于“开通”状态的时间比基线多0.72小时，且没有出现运动障碍，处于“关闭”状态的时间相应减少了0.75小时。在高剂量组中，通过帕金森病评定量表MDS-UPDRS第三部分为“停药”状态下bemdaneprocel一年期疗效进行评分，得到相较于基线降低13.0分的结果。低剂量组结果为较基线降低7.6分。此次更新的数据显示，第18个月时，bemdaneprocel继续保持了良好的耐受性，没有发生重大安全性问题。移植到大脑中的细胞存活并定植了下来，在第12个月停止免疫抑制治疗后，F-DOPA信号依然在增加。此外，与基线相比，两个剂量队列的探索性临床终点都有所改善，高剂量队列的受试者表现出更大的改善。和基线相比，高剂量组受试者处于“开通”状态的时间多2.7小时；处于“关闭”状态的时间相应减少了2.7小时。低剂量组受试者处于“开通”状态的时间比基线多0.2小时，处于“关闭”状态的时间相应减少了0.8小时。此外，高剂量组18个月时的疗效评分与基线相比降低了23分，低剂量组较基线降低了8.6分。RGX-202：公布1/2期临床试验的新数据REGENXBIO公司公布了其在研基因疗法RGX-202在4至11岁杜氏肌营养不良患者中进行的1/2期AFFINITY DUCHENNE试验的额外中期安全性和有效性数据。RGX-202是一款基于AAV8载体的基因疗法，旨在递送表达微肌营养不良蛋白的转基因进入骨骼肌和心肌组织。接受两种剂量水平的所有4例患者皆完成了在第三个月时的试验评估，分析显示，其体内RGX-202微肌营养不良蛋白的表达皆有所增加，并且血清肌酐激酶（CK）水平较基线有所下降，显示该疗法具潜在临床疗效。首位接受剂量水平2治疗的12.1岁患者的数据显示，在三个月时其RGX-202微肌营养不良蛋白表达为标准对照的75.7%，且在十周时观察到患者的血清CK水平较基线降低了77%。CK水平的升高与肌肉损伤有关，DMD患者的CK水平普遍升高。试验详细数据如下所示：▲RGX-202试验疗效结果摘要（图片来源：参考资料[14]）EXN407：公布1b/2a期临床试验数据Exonate公司公布了其主打候选药物EXN407在1b/2a期临床试验中获得积极结果。EXN407是一种每日两次的眼科配方，主要成分为SRPK1小分子抑制剂。这种眼药水配方利用SRPK1在血管内皮生长因子（VEGF）的选择性剪接中的作用，VEGF是一种在血管生长调节中起重要作用的蛋白质。通过抑制SRPK1，EXN407可以选择性地靶向导致视网膜血管疾病进展的VEGF亚型，抑制眼内渗漏血管的异常生长。此次公布的结果显示，EXN407具有良好的安全性和耐受性，以及明显的生物活性信号。与安慰剂组相比，EXN407组黄斑厚度持续减少，与先前报道的抗VEGF注射效果相仿。该试验结果进一步显示，EXN407组60%的患者血管渗漏显著减少，安慰剂组这一数值为20%。新闻稿指出，这些数据支持进一步开发EXN407成为治疗糖尿病视网膜病和糖尿病性黄斑水肿等视网膜血管疾病的首个外用治疗方法。Exonate计划将EXN407推进到2b期临床试验。UB-312：公布1期临床试验数据Vaxxinity公司公布了其用于治疗帕金森病的疫苗UB-312取得的积极临床数据。UB-312旨在靶向导致帕金森病和其他突触核蛋白病的毒性物质——聚集形式的α突触核蛋白（α-synuclein，aSyn）。通过点印迹法测定，UB-312诱导的抗体优先与聚集的aSyn结合，而几乎不与正常的aSyn单体结合。经种子扩增试验（SAA）测定，单次治疗后，300/100/100 µg剂量组患者脑脊液（CSF）中聚集的aSyn与基线相比下降了20%，而安慰剂组则增加了3%（p<0.05）。此外，根据UPDRS II临床量表的结果，CSF中可检测到UB-312诱导抗体的患者的日常生活能力有所改善（p<0.01）。这些数据还表明，大脑中聚集的aSyn减少与MDS-UPDRS II的变化之间存在相关性（R=0.52，p=0.001）。Vaxxinity公司的新闻稿指出，UB-312是首个可减少帕金森病患者CSF中病理性aSyn的候选免疫疗法。NT-0796：公布1b/2a期临床试验数据NodThera公司公布了其NLRP3炎症小体抑制剂NT-0796在帕金森病患者中开展的早期临床试验的积极数据。结果显示，NLRP3炎症小体抑制剂NT-0796的安全性和耐受性良好，可在28天内将帕金森病患者的主要神经炎症和炎症生物标志物（例如IL-1β、IL-6、CCL2、CXCL1和CXCL8）降至健康老年对照组的水平。此外，研究人员还观察到神经退行性标志物的减少，包括神经丝轻链（NfL）和sTREM2。药代动力学结果表明，NT-0796在大脑中的浓度可在24小时内保持不变，支持每日一次的给药方案。该研究表明，NT-0796有可能改变帕金森病的治疗模式，并通过改变疾病进程阻止疾病进展。大家都在看药明康德为全球生物医药行业提供一体化、端到端的新药研发和生产服务，服务范围涵盖化学药研发和生产、生物学研究、临床前测试和临床试验研发、细胞及基因疗法研发、测试和生产等领域。如您有相关业务需求，欢迎点击下方图片填写具体信息。▲如您有任何业务需求，请长按扫描上方二维码，或点击文末“阅读原文/Read more”，即可访问业务对接平台，填写业务需求信息▲欲了解更多前沿技术在生物医药产业中的应用，请长按扫描上方二维码，即可访问“药明直播间”，观看相关话题的直播讨论与精彩回放参考资料（可上下滑动查看）[1] Cullinan Oncology Announces U.S. FDA Clearance of Investigational New Drug Application for Novel MICA/B Antibody, CLN-619, for Relapsed/Refractory Multiple Myeloma. Retrieved March 4, 2024, from https://www.globenewswire.com/news-release/2024/03/01/2838731/0/en/Cullinan-Oncology-Announces-U-S-FDA-Clearance-of-Investigational-New-Drug-Application-for-Novel-MICA-B-Antibody-CLN-619-for-Relapsed-Refractory-Multiple-Myeloma.html[2] SELLAS Life Sciences Delivers Oral Presentation of SLS009 Phase 1 Data for Acute Myeloid Leukemia Patients at 2024 European School of Haematology (ESH) Conference. Retrieved March 4, 2024, from https://www.globenewswire.com/news-release/2024/03/01/2838804/0/en/SELLAS-Life-Sciences-Delivers-Oral-Presentation-of-SLS009-Phase-1-Data-for-Acute-Myeloid-Leukemia-Patients-at-2024-European-School-of-Haematology-ESH-Conference.html[3] Indaptus Therapeutics Announces Positive Results from Second Cohort of Phase 1 Trial; Company Initiates Multi-Dose Cohort. Retrieved March 4, 2024, from https://www.globenewswire.com/news-release/2024/03/04/2839435/0/en/Indaptus-Therapeutics-Announces-Positive-Results-from-Second-Cohort-of-Phase-1-Trial-Company-Initiates-Multi-Dose-Cohort.html[4] Avidity Biosciences Announces Positive AOC 1001 Long-term Data Showing Reversal of Disease Progression in People Living with Myotonic Dystrophy Type 1 Across Multiple Endpoints; Same Key Endpoints Agreed for Phase 3 HARBOR™ Trial. Retrieved March 4, 2024, from https://www.prnewswire.com/news-releases/avidity-biosciences-announces-positive-aoc-1001-long-term-data-showing-reversal-of-disease-progression-in-people-living-with-myotonic-dystrophy-type-1-across-multiple-endpoints-same-key-endpoints-agreed-for-phase-3-harbor-trial-302078020.html[5] Gabather reports initial positive results from the EEG/fMRI target engagement study. Retrieved March 7, 2024 from https://www.prnewswire.com/news-releases/gabather-reports-initial-positive-results-from-the-eegfmri-target-engagement-study-302082660.html[6] BlueRock Therapeutics phase I clinical trial for Parkinson’s disease continues to show positive trends at 18 months. Retrieved March 6, 2024, from https://www.globenewswire.com/news-release/2024/03/06/2841077/0/en/BlueRock-Therapeutics-phase-I-clinical-trial-for-Parkinson-s-disease-continues-to-show-positive-trends-at-18-months.html[7] PhotonPharma, Inc. Receives FDA Clearance for a First in Human Clinical Study for Stage III/IV Ovarian Cancer Treatment with the Investigational Autologous Vaccine Therapy, Innocell. Retrieved March 6, 2024, from https://pipelinereview.com/photonpharma-inc-receives-fda-clearance-for-a-first-in-human-clinical-study-for-stage-iii-iv-ovarian-cancer-treatment-with-the-investigational-autologous-vaccine-therapy-innocell/[8] AIDS Clinical Trial Group Presents Results from Phase 1 Study of ModeX Trispecific Antibody for the Treatment and Prevention of HIV l. Retrieved March 6, 2024, from https://www.globenewswire.com/news-release/2024/03/05/2840482/0/en/AIDS-Clinical-Trial-Group-Presents-Results-from-Phase-1-Study-of-ModeX-Trispecific-Antibody-for-the-Treatment-and-Prevention-of-HIV.html[9] Highlights to be presented at Novo Nordisk’s Capital Markets Day 2024. Retrieved March 7, 2024 from https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=167029[10] Lipella Pharmaceuticals Announces FDA Clearance of IND for LP-410 for Oral Graft-Versus-Host Disease, Advancing Clinical Pipeline. Retrieved March 6, 2024, from https://www.globenewswire.com/news-release/2024/03/05/2840362/0/en/Lipella-Pharmaceuticals-Announces-FDA-Clearance-of-IND-for-LP-410-for-Oral-Graft-Versus-Host-Disease-Advancing-Clinical-Pipeline.html[11] Allyx Therapeutics Announces Expansion into Parkinson’s Disease Clinical Research with Lead Compound ALX-001 Following IND Acceptance. Retrieved March 6, 2024, from https://www.globenewswire.com/news-release/2024/03/05/2840394/0/en/Allyx-Therapeutics-Announces-Expansion-into-Parkinson-s-Disease-Clinical-Research-with-Lead-Compound-ALX-001-Following-IND-Acceptance.html[12] Apogee Announces Positive Interim Results from Phase 1 Healthy Volunteer Trial for APG777, its Novel Half-Life Extended Anti-IL-13 Antibody for the Treatment for Atopic Dermatitis and Other Inflammatory Diseases, Exceeding its Trial Objectives Ahead of Schedule with Half-Life of Approximately 75 Days. Retrieved March 6, 2024, from https://www.globenewswire.com/news-release/2024/03/05/2840218/0/en/Apogee-Announces-Positive-Interim-Results-from-Phase-1-Healthy-Volunteer-Trial-for-APG777-its-Novel-Half-Life-Extended-Anti-IL-13-Antibody-for-the-Treatment-for-Atopic-Dermatitis-a.html[13] Exonate first-in-class eye drop Phase Ib/IIa trial data demonstrate safety and biological activity in treatment of diabetic retinopathy and diabetic macular oedema. Retrievd March 5, 2024, from https://www.businesswire.com/news/home/20240304540449/en[14] REGENXBIO ANNOUNCES NEW POSITIVE INITIAL EFFICACY DATA FROM AFFINITY DUCHENNE® TRIAL. Retrieved March 5, 2024 from https://regenxbio.gcs-web.com/news-releases/news-release-details/regenxbio-announces-new-positive-initial-efficacy-data-affinity[15] KURA ONCOLOGY REPORTS FIRST PATIENT DOSED IN TRIAL OF KO-2806 PLUS CABOZANTINIB IN RENAL CELL CARCINOMA. Retrieved March 7, 2024 from https://ir.kuraoncology.com/news-releases/news-release-details/kura-oncology-reports-first-patient-dosed-trial-ko-2806-plus[16] Innate Pharma: First Patient dosed in Phase 1/2 study of IPH6501 in relapsed /refractory B-Cell non-Hodgkin’s Lymphoma. Retrieved March 7, 2024 from https://markets.ft.com/data/announce/detail?dockey=600-202403060100BIZWIRE_USPRX____20240305_BW907062-1[17] OnCusp Therapeutics Announces First Patient Dosed in Phase 1 Trial of CUSP06 in Patients with Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors. Retrieved March 7, 2024 from https://www.prnewswire.com/news-releases/oncusp-therapeutics-announces-first-patient-dosed-in-phase-1-trial-of-cusp06-in-patients-with-platinum-refractoryresistant-ovarian-cancer-and-other-advanced-solid-tumors-302081277.html[18] Dragonfly has Received Milestone Payment Following Dosing of First Patient in AbbVie Phase 1 Clinical Trial Evaluating DF4101/ABBV-303. Retrieved March 7, 2024 from https://www.prnewswire.com/news-releases/dragonfly-has-received-milestone-payment-following-dosing-of-first-patient-in-abbvie-phase-1-clinical-trial-evaluating-df4101abbv-303-302078923.html[19] Vaxxinity Announces Positive Target Engagement Data from Phase 1 Clinical Trial for Parkinson’s Disease at AD/PD™ 2024. Retrieved March 7, 2024 from https://www.globenewswire.com/news-release/2024/03/07/2842413/0/en/Vaxxinity-Announces-Positive-Target-Engagement-Data-from-Phase-1-Clinical-Trial-for-Parkinson-s-Disease-at-AD-PD-2024.html[20] Mustang Bio Announces Publication in Nature Medicine of Data from Phase 1 Trial Evaluating MB-101 IL13Rα2-targeted CAR T-Cells in High-Grade Glioma. Retrieved March 7, 2024 from https://ir.mustangbio.com/news-events/press-releases/detail/175/mustang-bio-announces-publication-in-nature-medicine-of[21] Alligator Bioscience and Aptevo Therapeutics Announce Positive Interim Data of Dose Escalation Phase of ALG.APV-527 Phase 1 Study in Solid Tumor Cancers Expressing Tumor Antigen 5T4. Retrieved March 7, 2024 from https://alligatorbioscience.se/en/mfn_news/alligator-bioscience-and-aptevo-therapeutics-announce-positive-interim-data-of-dose-escalation-phase-of-alg-apv-527-phase-1-study-in-solid-tumor-cancers-expressing-tumor-antigen-5t4/[22] NodThera’s NLRP3 Inhibitor NT-0796 Reverses Neuroinflammation in Parkinson’s Disease Phase Ib/IIa Trial. Retrieved March 7, 2024 from https://www.nodthera.com/news/nodtheras-nlrp3-inhibitor-nt-0796-reverses-neuroinflammation-in-parkinsons-disease-phase-ib-iia-trial/免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。分享，点赞，在看，聚焦全球生物医药健康创新