预约演示
更新于：2025-11-15
Luliconazole
卢立康唑
更新于：2025-11-15
概要
基本信息
药物类型 小分子化药 |
别名 Luconac Solution、Luliconazole (JAN/USAN/INN)、Lulifin + [12] |
作用方式 抑制剂 |
作用机制 fungal CYP51A1抑制剂(真菌细胞色素P450家族成员51抑制剂) |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H9Cl2N3S2 |
InChIKeyYTAOBBFIOAEMLL-REQDGWNSSA-N |
CAS号187164-19-8 |
关联
21
项与 卢立康唑 相关的临床试验CTRI/2025/05/087906
Therapeutic Evaluation of a Topical Unani Formulation in Pityriasis Versicolor (Bahaq) and Its Comparative Study with Luliconazole 1 Percent Ointment: A Randomized, Parallel Group, Open-Label, Standard-Controlled Clinical Trial - NIL
IRCT20240711062393N1
Efficacy Evaluation of Loaded Nanostructured Lipid Carriers (NLC) with Luliconazole in Treatment-Resistant Dermatophytosis
CTRI/2024/03/063613
A Comparative study to evaluate the efficacy and safety of topical Luliconazole versus topical Ciclopirox olamine among patients with Tinea corporis/cruris - NIL
100 项与 卢立康唑 相关的临床结果
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100 项与 卢立康唑 相关的转化医学
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100 项与 卢立康唑 相关的专利（医药）
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301
项与 卢立康唑 相关的文献（医药）2025-10-01MYCOPATHOLOGIA
Topical Luliconazole Treatment for Hyperkeratotic Tinea Pedis
Article
作者: Noguchi, Hiromitsu ; Fukushima, Satoshi ; Kubo, Masahide ; Kashiwada-Nakamura, Kayo ; Kano, Rui ; Ohara, Sayaka ; Hayashi, Daiki ; Matsumoto, Tadahiko
Chronic hyperkeratotic tinea pedis is a treatment-resistant infection. We evaluated the efficacy of a 3-month course of topical 1% luliconazole in 21 hyperkeratotic tinea pedis patients. The diagnosis was confirmed through microscopy and culture. The lesion area was assessed monthly using a software program. Clinical responses were classified into five categories from "cured" to "no change." Among the isolates, one terbinafine-resistant T. rubrum strain was detected. The mean lesion area decreased significantly over 3 months, with an average improvement rate of 94.1% ± 12.7% and a cure rate of 61.9%. The mean amount of luliconazole used per foot was 27.5 ± 9.7 g monthly. The resistant case showed a partial improvement with topical luliconazole and was successfully treated with oral fosravuconazole. These findings suggest that 1% topical luliconazole is effective for treating hyperkeratotic tinea pedis.
2025-08-05Microbiology Spectrum
Article
作者: Li, Xiaofang ; Liu, Weida ; Xie, Wenting ; Liang, Guanzhao ; Mei, Huan ; Zheng, Hailin ; Kong, Xue ; Ge, Naicen
ABSTRACT:
The worldwide emergence of
Trichophyton indotineae
has garnered significant attention due to its growing resistance to conventional antifungal therapies, posing significant challenges to the effective management of dermatophytosis. The
in vitro
activities of 16 antifungals were tested against 37
T. indotineae
isolates using the broth microdilution method according to Clinical and Laboratory Standards Institute protocol M38-A3. Luliconazole and amorolfine exhibited low MICs, while itraconazole showed moderately decreased susceptibility, making them preferred treatment options. Echinocandins demonstrated favourable
in vitro
activity against
T. indotineae
, but their potential as therapeutic alternatives for recalcitrant dermatophytosis remains uncertain due to pharmacokinetic and pharmacodynamic limitations. In contrast, terbinafine, fluconazole, griseofulvin, oteseconazole, isavuconazole, ravuconazole, and amphotericin B exhibited elevated MICs for many strains, with strong correlations between certain azoles, indicating potential cross-resistance. A difference in the susceptibility to terbinafine and voriconazole between Chinese and Indian isolates was observed. These findings could provide valuable insights into antifungal resistance patterns and help guide treatment strategies for
T. indotineae
infections.
IMPORTANCE:
Trichophyton indotineae
is a novel emerging dermatophyte that has rapidly spread globally in recent years. Its resistance to first-line antifungal agents, particularly terbinafine and fluconazole, has significantly limited treatment options, emphasizing the urgent need for alternative therapies. This study provides comprehensive antifungal susceptibility data for 16 available antifungal agents, offering valuable insights into potential treatment strategies.
2025-07-01JOURNAL OF DERMATOLOGY
Widespread Majocchi's Granuloma Caused by Multidrug‐Resistant Trichophyton rubrum Successfully Treated With Amphotericin B and Posaconazole
Article
作者: Noguchi, Hiromitsu ; Hiruma, Masataro ; Takamori, Kenji ; Kano, Rui ; Suga, Yasushi ; Matsumoto, Tadahiko ; Kimura, Utako
ABSTRACT:
We encountered a 60‐year‐old Japanese female patient with disseminated dermatophytosis caused by terbinafine‐resistant Trichophyton rubrum with mutant SQLE (Leu393Phe substitution). Histopathology showed fungus in the dermis, indicating Majocchi granuloma. Oral fosravuconazole and topical luliconazole were administered for 18 months, resulting in invasive dermatophytosis with a high β‐d‐glucan level of 7320 pg/mL. The MICs of amphotericin B, posaconazole, griseofulvin, itraconazole, voriconazole, ravuconazole, and terbinafine were 0.5, 0.5, 8, 16, 8, 16, and 32 μg/mL, respectively. Amphotericin B for 6 months followed by oral posaconazole for another 6 months cured the disease. Posaconazole may be a promising agent for the treatment of multidrug‐resistant dermatophytes. We present the first reported case of multiazole‐resistant T. rubrum resulting from prolonged fosravuconazole treatment.
100 项与 卢立康唑 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 手癣 | 美国 | 2018-02-20 | |
| 甲癣 | 日本 | 2016-01-22 | |
| 皮肤念珠菌病 | 中国 | 2012-06-27 | |
| 真菌病 | 韩国 | 2010-02-01 | |
| 体癣 | 日本 | 2005-07-31 | |
| 股癣 | 日本 | 2005-07-31 | |
| 足癣 | 日本 | 2005-07-31 | |
| 念珠菌病 | 日本 | 2005-04-11 | |
| 癣 | 日本 | 2005-04-11 | |
| 花斑癣 | 日本 | 2005-04-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性皮肤黏膜念珠菌病 | 药物发现 | 美国 | 2011-01-11 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 75 | (Luliconazole Cream 1%) | 繭憲鹹齋淵願簾遞鏇餘(繭鬱窪廠襯衊鬱鹽糧衊) = 襯窪廠衊築網願窪齋積 構艱艱窪鏇顧鑰衊網積 (製觸製網繭憲餘鏇壓膚, 2.93) 更多 | - | 2019-11-27 | ||
Vehicle Cream (Vehicle Cream) | 繭憲鹹齋淵願簾遞鏇餘(繭鬱窪廠襯衊鬱鹽糧衊) = 遞膚觸糧糧鹽獵獵廠廠 構艱艱窪鏇顧鑰衊網積 (製觸製網繭憲餘鏇壓膚, NA) 更多 | ||||||
临床4期 | 30 | (Tinea Pedis) | 製淵獵襯襯製壓襯顧鏇(鑰憲範顧齋齋築觸網構) = 構鏇鹹積憲醖遞範窪壓 網顧構築憲簾鏇築鹽繭 (醖膚醖鏇獵鏇齋願憲積, 1.71) 更多 | - | 2019-11-27 | ||
(Tinea Cruris) | 糧願鏇夢夢襯鹽糧築鹹(膚鹹繭製製築鬱鏇鹹鏇) = 觸繭廠繭築膚齋淵構獵 選構窪艱蓋觸顧遞網襯 (齋遞繭餘襯夢網簾繭鏇, 13.62) 更多 | ||||||
临床4期 | 20 | Omeprazole 40 mg+Luliconazole Cream 1% | 壓範餘遞積醖選範衊鏇(淵齋遞餘壓餘壓夢構觸) = 襯鏇廠餘鹽壓簾夢淵醖 範網觸膚積膚壓膚範築 (壓憲襯獵簾鑰鏇齋簾膚, 0) 更多 | - | 2019-11-27 |
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