预约演示
更新于：2026-02-26
Levalbuterol Tartrate
左沙丁胺醇
更新于：2026-02-26
概要
基本信息
在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2005-03-11), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C30H48N2O12 |
InChIKeyVNVNZKCCDVFGAP-FPDJQMMJSA-N |
CAS号661464-94-4 |
关联
32
项与 左沙丁胺醇 相关的临床试验CTRI/2025/07/091233
Randomized controlled clinical trial to compare the efficacy of oral administration of tekrajras syrup with levosalbutamol syrup in kaphaj kasa in children - NIL
NCT06422689
ANCHOR - Assessment of Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
CTR20240652
酒石酸左沙丁胺醇吸入气雾剂在中国健康受试者空腹状态下的单中心、随机、开放、单剂量、两序列、四周期、完全重复交叉生物等效性试验
100 项与 左沙丁胺醇 相关的临床结果
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100 项与 左沙丁胺醇 相关的转化医学
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100 项与 左沙丁胺醇 相关的专利（医药）
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349
项与 左沙丁胺醇 相关的文献（医药）2026-02-02Pakistan Journal of Pharmaceutical Sciences
Efficacy Of Levosalbutamol For Lung Cancer Patients Receiving Postoperative Sputum Expectoration By High-Frequency Chest Wall Oscillation
Article
作者: Leng, Hongrui ; Wang, Yongmei
Background: Sputum expectoration is an important nursing link for lung cancer patients after thoracoscopic lobectomy. Objectives: To evaluate the efficacy of levosalbutamol as an adjunct to high-frequency chest wall oscillation (HFCWO) for sputum expectoration in lung cancer patients after thoracoscopic lobectomy. Methods: Sixty lung cancer patients who underwent thoracoscopic lobectomy were retrospectively divided into control (n = 30) and study (n = 30) group. After thoracoscopic lobectomy, both groups received the sputum expectoration by HFCWO for one week. In addition, the study group was treated with levosalbutamol for one week. The postoperative sputum volume was recorded. The pulmonary complications were observed. The preoperative and postoperative pulmonary function indices, blood gas indices and inflammatory response indices were also observed. Results: The study group showed a significantly lower sputum volume on postoperative day 2, 3, 4 and 5, compared to control group. On postoperative day 7, the study group demonstrated significantly better function indices, blood gas indices and inflammatory response indices compared to control group. The pulmonary complications showed no significant different between two groups. Conclusion: Levosalbutamol as an adjunct can enhance the efficacy for lung cancer patients receiving postoperative sputum expectoration by HFCWO, which is evidenced by elevated sputum clearance, enhanced pulmonary function, increased oxygenation and declined inflammatory response.
2024-10-01DRUG METABOLISM AND DISPOSITION
Clotrimazole Identified as a Selective UGT2B4 Inhibitor Using Canagliflozin-2′-O-Glucuronide Formation as a Selective UGT2B4 Probe Reaction
Article
作者: Goosen, Theunis C ; Ferguson, Nicholas ; Lapham, Kimberly ; Niosi, Mark
UGT2B4 is a highly expressed drug-metabolizing enzyme in the liver contributing to the glucuronidation of several drugs. To enable quantitatively assessing UGT2B4 contribution toward metabolic clearance, a potent and selective UGT2B4 inhibitor that can be used for reaction phenotyping was sought. Initially, a canagliflozin-2'-O-glucuronyl transferase activity assay was developed in recombinant UGT2B4 and human liver microsomes (HLM) [±2% bovine serum albumin (BSA)]. Canagliflozin-2'-O-glucuronidation (C2OG) substrate concentration at half-maximal velocity value in recombinant UGT2B4 and HLM were similar. C2OG formation intrinsic clearance was five- to seven-fold higher in incubations containing 2% BSA, suggesting UGT2B4 susceptibility to the inhibitory unsaturated long-chain fatty acids released during the incubation. Monitoring for C2OG formation, 180 compounds were evaluated for UGT2B4 inhibition potency in the presence and absence of 2% BSA. Compounds that exhibited an apparent UGT2B4 IC50 of < 1 μM in HLM with 2% BSA were evaluated for inhibition of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B10, UGT2B15, and UGT2B17 catalytic activities to establish selectivity suitable for supporting UGT reaction phenotyping. In this study, clotrimazole was identified as a potent UGT2B4 inhibitor (HLM apparent IC50 of 11 to 35 nM ± 2% BSA). Moreover, clotrimazole exhibited selectivity for UGT2B4 inhibition (>24-fold) over the other UGT enzymes evaluated. Additionally, during this study it was discovered that the previously described UGT2B7 inhibitors 16α- and 16β-phenyllongifolol also inhibit UGT2B4. Clotrimazole, a potent and selective UGT2B4 inhibitor, will prove essential during UGT reaction phenotyping. SIGNIFICANCE STATEMENT: To mechanistically evaluate drug interactions, it is essential to understand the contribution of individual enzymes to the metabolic clearance of a drug. The present study describes the development of a UGT2B4 activity assay that enabled the discovery of the highly selective and potent UGT2B4 inhibitor clotrimazole. Clotrimazole can be used in UGT reaction phenotyping studies to estimate fractional contribution of UGT2B4.
2024-09-24JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Greenhouse Gas Emissions and Costs of Inhaler Devices in the US
Article
作者: Wilkinson, Alexander J. K. ; Tirumalasetty, Jyothi ; Prescott, Hallie C. ; Miller, Shelie A. ; Rabin, Alexander S. ; DeTata, Serena ; Arroyo, Anna Chen
This study assesses mean emissions and costs and estimated total yearly emissions and costs for US-branded inhalers prescribed to Medicare Part D and Medicaid beneficiaries.
100 项与 左沙丁胺醇 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 支气管痉挛 | 美国 | 2005-03-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 气道病变 | 临床3期 | 美国 | 2014-07-01 | |
| 哮喘 | 临床3期 | 加拿大 | 2003-01-01 | |
| 运动诱发哮喘 | 临床3期 | 美国 | 2002-10-01 | |
| 慢性阻塞性肺疾病 | 临床3期 | 美国 | 2002-02-01 | |
| 慢性阻塞性肺疾病 | 临床3期 | 加拿大 | 2002-02-01 | |
| 急性哮喘 | 临床3期 | 美国 | 2000-11-01 | |
| 过敏性哮喘 | 临床2期 | - | 2006-04-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 18 | (Levalbuterol Tartrate HFA Inhalation Aerosol Plus Placebo HFA) | 願糧衊鹹齋構蓋壓鹽範 = 繭繭築醖廠選鹽網構鹽 廠糧淵餘淵膚窪網鬱築 (網觸積膚鑰鬱壓積繭鹹, 廠襯繭獵醖襯願簾餘醖 ~ 齋蓋憲簾獵顧蓋遞膚鑰) 更多 | - | 2016-02-03 | ||
(Levalbuterol Tartrate HFA Inhalation Aerosol Plus Levalbuterol) | 願糧衊鹹齋構蓋壓鹽範 = 艱醖網齋廠淵鏇艱艱壓 廠糧淵餘淵膚窪網鬱築 (網觸積膚鑰鬱壓積繭鹹, 鹽鬱鹹築廠醖鹽鹽鑰築 ~ 網構壓簾獵壓夢鹽選餘) 更多 | ||||||
临床3期 | 197 | Placebo (Placebo) | 齋選製鬱積鹽積構簾鏇(繭鏇遞衊鬱夢糧壓顧顧) = 鹽糧壓夢衊鬱築憲獵簾 鬱繭鏇艱遞餘鬱艱齋範 (網顧築鹽觸壓鹹範襯繭, 2.722) 更多 | - | 2014-07-28 | ||
(Levalbuterol MDI) | 齋選製鬱積鹽積構簾鏇(繭鏇遞衊鬱夢糧壓顧顧) = 網膚鑰醖餘範網夢築鏇 鬱繭鏇艱遞餘鬱艱齋範 (網顧築鹽觸壓鹹範襯繭, 2.092) 更多 | ||||||
临床4期 | 81 | (Continuous Levalbuterol (R) Nebulized Solution) | 鬱淵顧積遞獵衊積網觸(鹽窪鑰繭製膚夢齋鹽積) = 艱蓋糧淵壓餘鬱憲餘顧 齋蓋鹽衊製壓選簾廠顧 (繭醖繭鬱鹽網築築衊醖, 遞網窪鑰鏇鏇鬱糧廠糧 ~ 糧壓鹽願願衊願廠襯憲) 更多 | - | 2013-03-14 | ||
(Continuous Racemic (R+S) Albuterol) | 鬱淵顧積遞獵衊積網觸(鹽窪鑰繭製膚夢齋鹽積) = 壓鏇遞鹹鑰糧顧願選鹹 齋蓋鹽衊製壓選簾廠顧 (繭醖繭鬱鹽網築築衊醖, 淵簾廠顧鹽製壓選襯餘 ~ 遞製築顧築衊膚構遞遞) 更多 |
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