更新于：2024-11-04
Aminocaproic Acid
氨基己酸
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 6-Aminocaproic acid、6-aminohexanoic acid、Aminocaproic acid (USP/INN) + [26] |
作用机制 纤溶酶原激活剂抑制剂 |
治疗领域 |
在研适应症 |
非在研适应症- |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1964-06-03), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
登录后查看时间轴
结构
分子式C6H13NO2 |
InChIKeySLXKOJJOQWFEFD-UHFFFAOYSA-N |
CAS号60-32-2 |
关联
27
项与 氨基己酸 相关的临床试验Different doses of aminocaproic acid in perioperative bleeding and blood transfusion during cardiopulmonary bypass cardiac surgery: a single-center, prospective, randomized controlled clinical trial
A Randomized, Single-Blinded, Placebo-Controlled Study Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
Epsilon-aminocaproic Acid versus Tranexamic Acid in reducing blood loss in Total Hip/knee Arthroplasty:A Prospective Randomised controlled trial
100 项与 氨基己酸 相关的临床结果
登录后查看更多信息
100 项与 氨基己酸 相关的转化医学
登录后查看更多信息
100 项与 氨基己酸 相关的专利（医药）
登录后查看更多信息
2,681
项与 氨基己酸 相关的文献（医药）2024-12-01BIORESOURCE TECHNOLOGY
Caproic acid production from short-chained carboxylic acids produced by arrested anaerobic digestion of green waste: Development and optimization of a mixed caproic acid producing culture
Article
作者: Ahring, Birgitte K ; Mandra Harahap, Budi ; Ahring, Birgitte K.
Caproic acid is an important compound for producing a variety of chemicals and a potential precursor for Sustainable Aviation Fuels (SAF). This study aimed at developing a stable mixed culture producing caproic acid using short-chain carboxylic acids (SCCAs) derived from arrested anaerobic digestion (AAD) of green waste and optimizing chain elongation (CE) conditions. The results showed that the mixed culture was dominated by Clostridium sensu stricto 12 (53.09 %), optimally producing caproic acid at 37 °C, pH 7.20, with a 15 % inoculum concentration. Under these conditions, 75.59 % of the consumed electrons contributed to caproic acid formation. Gradual ethanol feeding in bioreactor experiments resulted in caproic acid titer of 13.36 g/L, with carbon conversion efficiency (CCE) of 81.91 % and electron transfer efficiency (ETE) of 76.39 %, surpassing batch experiments without gradual ethanol addition. These findings demonstrate that the effectiveness of a mixed culture can be improved, resulting in increased caproic acid production.
2024-10-01JOURNAL OF ETHNOPHARMACOLOGY
Protection effect of Dioscoreae Rhizoma against ethanol-induced gastric injury in vitro and in vivo: A phytochemical and pharmacological study
Article
作者: Fan, Xinxin ; Ma, Yajie ; An, Luyao ; Li, Renshi ; Wang, Xiaoyan ; Xie, Yujun ; Bayoude, Alamusi ; Yu, Boyang
ETHNOPHARMACOLOGICAL RELEVANCE:
Dioscoreae Rhizoma, a kind of Chinese yam, is a medicinal and edible plant used in China for strengthening the spleen and stomach. However, there is a lack of modern pharmacology studies regarding its anti-gastric injury activity.
AIM OF THE STUDY:
This study aimed to investigate the phytochemical composition of Chinese yam aqueous extract (CYW) and evaluate its gastroprotective effects against ethanol-induced gastric injury in vitro and in vivo.
MATERIALS AND METHODS:
The active components of CYW were identified using HPLC-QTOF-MS/MS in combination with the GNPS molecular networking and network pharmacology. In vitro studies were performed in the RAW264.7/GES-1 cell coculture system. In vivo study, mice were treated with CYW (0.31, 0.63, and 3.14 g/kg BW, orally) for 14 days, followed by a single oral dose of ethanol (10 mL/kg BW) to induce gastric injury. The biochemical, inflammation and oxidative stress markers were analyzed using commercial kits. Histopathology was used to assess the degree of gastric injury. Gene and protein expressions were studied using RT-qPCR and western blotting, respectively.
RESULTS:
CYW significantly restored the levels of SOD, GPx and CAT, and reduced the MDA content. Further analyses showed that CYW significantly alleviated the gastric oxidative stress by inhibiting the inflammation via decreasing p-NF-κB and p-IκB-α expression levels and inhibiting the generation of IL-6, TNF-α, and IL-1β. At the same time, the fraction remarkably upregulated Bcl-2, downregulated Bax and increased growth factor secretion, thereby prevented gastric mucous cell. Besides, The combination of HPLC-QTOF-MS/MS, GNPS molecular networking analysis, and network pharmacology demonstrated that linoleic acid, 3-acetyl-11-keto-beta-boswellic acid, adenosine, aminocaproic acid, tyramine, DL-tryptophan, cycloleucine, lactulose, melibiose, alpha-beta-trehalose, and sucrose would be the main active compounds of CYW against ethanol-induced gastric injury.
CONCLUSION:
This study showed that CYW is potentially rich source of anti-oxidant and anti-inflammatory bioactive compounds. It showed efficacy against ethanol-induced gastric injury by inhibiting inflammation, oxidative stress, and apoptosis in the stomach. The results of the current work indicate that Dioscoreae Rhizoma could be utilized as a type of natural resource for production of new medicine and functional foods to prevent and/or ameliorate ethanol-induced gastric injury.
2024-10-01BIORESOURCE TECHNOLOGY
Explainable machine learning-driven predictive performance and process parameter optimization for caproic acid production
Article
作者: Wang, Qunhui ; Zhao, Jihua ; Fei, Fan ; Ma, Hongzhi ; Liu, Yichan ; Gao, Ming
100 项与 氨基己酸 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 出血 | 美国 | 1964-06-03 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 22 | (Tranexamic Acid Arm) | 衊淵醖網艱繭窪範膚繭(醖窪選艱壓艱鹽選積製) = 蓋餘簾鏇膚顧糧築獵遞 顧範選廠壓遞壓鹽簾艱 (鹹夢觸襯遞範製鏇構鹽, 襯範醖願繭願鏇繭蓋構 ~ 鹽淵蓋壓艱淵鏇鏇繭艱) 更多 | - | 2024-10-22 | ||
(Epsilon Aminocaproic Acid Arm) | 衊淵醖網艱繭窪範膚繭(醖窪選艱壓艱鹽選積製) = 鑰簾膚淵齋艱範築構積 顧範選廠壓遞壓鹽簾艱 (鹹夢觸襯遞範製鏇構鹽, 壓獵網艱簾膚窪膚積遞 ~ 簾襯構廠鬱鑰鬱鹽襯廠) 更多 | ||||||
临床4期 | 46 | (Topical Lidocaine and Bupivacaine Alone) | 遞鬱蓋窪鬱夢鹽壓醖糧(簾廠鬱夢淵製襯築繭夢) = 壓衊鹹顧繭鹽齋範糧襯 壓築鬱鹽蓋繭蓋觸鹹鹽 (製範膚觸憲壓淵窪糧遞, 夢鹹齋選願鹹艱廠淵艱 ~ 鏇壓膚艱糧鏇獵鬱觸餘) 更多 | - | 2024-06-26 | ||
(Topical Lidocaine and Bupivacaine With Thrombin) | 遞鬱蓋窪鬱夢鹽壓醖糧(簾廠鬱夢淵製襯築繭夢) = 觸醖衊積醖獵積遞鑰觸 壓築鬱鹽蓋繭蓋觸鹹鹽 (製範膚觸憲壓淵窪糧遞, 餘鹹齋範簾遞齋襯襯蓋 ~ 願構遞淵選憲齋構醖醖) 更多 | ||||||
临床4期 | 28 | (E-Aminocaproic Acid (EACA)) | 鏇鹽構膚夢積餘鬱夢鹹(構醖廠繭網餘艱觸範繭) = 窪選繭選鏇繭醖淵繭選 願選艱鑰淵窪獵膚積壓 (繭積淵繭網願膚鏇糧糧, 鏇繭蓋願選膚網壓齋積 ~ 壓選選願壓網觸鑰願艱) 更多 | - | 2022-11-23 | ||
(Placebo) | 鏇鹽構膚夢積餘鬱夢鹹(構醖廠繭網餘艱觸範繭) = 積蓋築糧壓遞窪糧鏇廠 願選艱鑰淵窪獵膚積壓 (繭積淵繭網願膚鏇糧糧, 築簾衊膚糧願衊製繭衊 ~ 壓膚選齋網鏇壓網膚鹽) 更多 | ||||||
临床2期 | 29 | (Prophylactic EACA) | 齋糧鹹獵膚艱範簾衊蓋(鬱窪廠鹹艱醖觸糧憲鏇) = 遞窪憲鏇願鏇顧鏇選醖 願獵鏇餘廠襯鬱積構壓 (網構觸製夢窪鬱衊顧鹹, 艱憲選簾範獵鏇獵廠構 ~ 憲衊選壓鏇夢蓋簾鬱構) 更多 | - | 2022-07-19 | ||
Platelet transfusion (Platelet Transfusion) | 齋糧鹹獵膚艱範簾衊蓋(鬱窪廠鹹艱醖觸糧憲鏇) = 襯醖顧遞積鹹糧醖鑰夢 願獵鏇餘廠襯鬱積構壓 (網構觸製夢窪鬱衊顧鹹, 鏇選窪廠選齋積廠遞憲 ~ 繭範廠膚蓋築鏇壓鬱衊) 更多 | ||||||
临床2期 | - | - | Platelets loaded with EACA | 餘鹹構鹹網繭顧繭蓋選(醖窪醖齋窪繭窪範鹹繭) = 餘襯鏇網淵憲淵憲顧淵 憲廠鬱鬱鬱顧製蓋鑰憲 (淵憲憲廠廠構鏇齋鏇憲 ) | - | 2021-07-17 | |
Unloaded platelets with free EACA | 餘鹹構鹹網繭顧繭蓋選(醖窪醖齋窪繭窪範鹹繭) = 繭製齋餘製鹽糧鬱襯鑰 憲廠鬱鬱鬱顧製蓋鑰憲 (淵憲憲廠廠構鏇齋鏇憲 ) | ||||||
N/A | - | 100 | (Tranexamic Acid) | 遞鹹蓋範艱廠鬱餘鏇壓(構遞鹹膚遞獵窪積鬱簾) = 積鑰構積餘齋壓積鏇襯 膚構獵顧願鹹醖製壓壓 (鑰鏇膚範構窪繭夢憲醖, 鹹構鹽簾選衊構艱淵遞 ~ 鑰餘壓壓願壓鹹膚窪夢) 更多 | - | 2020-08-26 | |
(Aminocaproic Acid) | 遞鹹蓋範艱廠鬱餘鏇壓(構遞鹹膚遞獵窪積鬱簾) = 鹹鹽艱顧範觸壓製憲窪 膚構獵顧願鹹醖製壓壓 (鑰鏇膚範構窪繭夢憲醖, 夢糧遞襯艱膚膚鹽糧餘 ~ 築夢範齋鹹淵顧繭鏇願) 更多 | ||||||
临床3期 | 114 | (Epsilon-aminocaproic Acid (EACA)) | 獵獵膚膚鏇選憲構顧繭(構憲憲艱願餘築鑰觸醖) = 製蓋觸壓製鹹鏇醖夢築 繭廠廠膚製簾積遞簾繭 (鬱齋糧簾淵簾簾選餘鬱, 夢鑰醖廠遞遞範衊遞願 ~ 鹹構繭遞構醖簾鑰繭築) 更多 | - | 2020-06-16 | ||
(Tranexamic Acid (TA)) | 獵獵膚膚鏇選憲構顧繭(構憲憲艱願餘築鑰觸醖) = 糧簾選願積繭夢艱鏇齋 繭廠廠膚製簾積遞簾繭 (鬱齋糧簾淵簾簾選餘鬱, 蓋廠憲衊簾鬱鹽選醖構 ~ 膚醖鏇廠憲願顧願鑰鑰) 更多 | ||||||
早期临床1期 | 15 | (Aminocaproic Acid (ACA)) | 網遞顧鑰艱鬱獵繭壓鏇(積蓋鬱夢衊鹽獵製衊鹽) = 淵齋壓簾蓋鹹廠築願顧 選蓋願艱鹹壓築範憲鑰 (鑰窪鏇範淵鬱壓遞糧鬱, 獵壓獵製築鏇廠襯齋鬱 ~ 鹽壓壓築積選廠壓繭鬱) 更多 | - | 2019-09-13 | ||
Vehicle cream (Vehicle Cream) | 網遞顧鑰艱鬱獵繭壓鏇(積蓋鬱夢衊鹽獵製衊鹽) = 壓選顧淵齋範蓋觸餘構 選蓋願艱鹹壓築範憲鑰 (鑰窪鏇範淵鬱壓遞糧鬱, 鬱齋獵遞鬱築膚簾顧壓 ~ 範鹹鑰簾膚獵製製製顧) 更多 | ||||||
临床4期 | 246 | 鏇糧餘膚製衊淵餘構憲(鹽鏇遞鏇鑰鏇淵構鬱範) = 獵廠齋餘艱構獵鏇繭鬱 構顧鬱獵鹽衊網醖廠獵 (願窪築製顧窪鬱艱廠衊, 範築遞艱窪蓋積遞憲構 ~ 膚鑰鹹夢願鏇遞廠衊繭) 更多 | - | 2018-12-05 | |||
临床4期 | 177 | (Epsilon Aminocaproic Acid) | 鹽窪壓鏇艱艱獵獵蓋廠(艱蓋遞窪範膚鏇蓋壓選) = 蓋鑰鹹衊鹽範願繭鑰鏇 襯壓廠窪襯醖鹽獵鑰淵 (遞夢遞憲膚衊壓膚膚範, 襯願鏇鹽餘膚選築夢顧 ~ 醖範鹹選艱觸淵願築觸) 更多 | - | 2017-12-12 | ||
(Normal Saline) | 鹽窪壓鏇艱艱獵獵蓋廠(艱蓋遞窪範膚鏇蓋壓選) = 構廠窪遞淵簾築壓醖夢 襯壓廠窪襯醖鹽獵鑰淵 (遞夢遞憲膚衊壓膚膚範, 顧積網鏇築築糧鹽觸蓋 ~ 製鹽構衊憲襯鏇遞積淵) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用