预约演示
更新于：2025-09-18
Bupivacaine Hydrochloride
盐酸布比卡因
更新于：2025-09-18
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1969-09-03), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C18H31ClN2O2 |
InChIKeyHUCIWBPMHXGLFM-UHFFFAOYSA-N |
CAS号73360-54-0 |
关联
1,633
项与 盐酸布比卡因 相关的临床试验NCT07146685
Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study
NCT05575999
Pain Management in Cardiac Implantable Electronic Device Insertion; Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain
NCT04336046
Ultrasound Guided Bilateral Erector Spinae Block as Analgesia for Adolescent Idiopathic Scoliosis Correction
100 项与 盐酸布比卡因 相关的临床结果
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100 项与 盐酸布比卡因 相关的转化医学
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100 项与 盐酸布比卡因 相关的专利（医药）
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11,337
项与 盐酸布比卡因 相关的文献（医药）2025-12-31STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3)
Article
作者: Forster, Gina L. ; Yaeger, Jazmine D. W. ; Buchanan, Michael W. ; Lowry, Christopher A. ; Rogers, Joshua T. ; Watt, Michael J. ; Feng, Na ; Scholl, Jamie L. ; Renner, Kenneth J.
Previous studies have shown that corticosterone rapidly alters extracellular serotonin (5-hydroxytryptamine; 5-HT) concentrations in the dorsomedial hypothalamus (DMH) of adult male rats, suggesting a role for corticosterone actions in the DMH in regulation of physiological and behavioral responses. Whether or not corticosterone also rapidly alters extracellular serotonin concentrations in the DMH of female rats, and the dependence of this effect on ovarian hormones, is not known. To determine the effects of 17β-estradiol (E2), progesterone (P), and corticosterone on extracellular concentrations of serotonin in the DMH, corticosterone and/or P were delivered into the DMH of ovariectomized rats via reverse microdialysis in E2-primed rats. Combined, but not separate, delivery of corticosterone and P into the DMH rapidly and transiently increased extracellular 5-HT concentrations, a result that was dependent upon circulating E2. This effect of corticosterone on DMH 5-HT was replicated by local perfusion of the organic cation transporter 3 (OCT3) competitive inhibitor normetanephrine. Intra-DMH infusions of either corticosterone or normetanephrine also reversibly suppressed lordosis responses in E2 + P-primed females. These results suggest that ovarian hormones in combination with corticosterone modulate OCT3-mediated 5-HT clearance in the DMH, potentially representing an adaptive mechanism that allows sexually receptive females to respond rapidly to acute stressors.
2025-11-01BURNS
Bupivacaine hydrochloride-soaked dressings versus subcutaneous infiltration for postoperative analgesia in skin graft donor sites
Article
作者: Mohamed, Shadwa Rabea ; Elsayed, Mohab Abdelhalim ; Sabry, Mohamed
BACKGROUND:
Skin grafting is associated with postoperative pain. Bupivacaine hydrochloride, a local anesthetic, has been studied for its effectiveness in providing analgesia for donor sites following skin grafting. This study aimed to compare the efficacy of bupivacaine hydrochloride-soaked dressings with subcutaneous infiltration for managing postoperative donor site pain in patients undergoing skin grafting procedures.
PATIENT AND METHODS:
This randomized, controlled, double-blinded prospective study included 90 patients. The study participants were divided into three equal groups: Group A (bupivacaine-soaked dressing), Group B (subcutaneous infiltration), and Group C (control received conventional dressing without any adjuvants). Pain scores, ketorolac analgesia, and fentanyl requirements were recorded.
RESULTS:
Both Group A and Group B exhibited significantly lower postoperative pain scores compared to Group C (p < 0.01). The time to first analgesic request was significantly prolonged in Groups A and B relative to Group C (p < 0.0001). Furthermore, the frequency of analgesic use was markedly reduced: 80.0 % of patients in Group A and 66.7 % in Group B required ketorolac only 1-2 times, whereas 96.7 % of patients in Group C required it more than twice (p < 0.0001). Fentanyl supplementation was rarely needed in Group A (0 %) and infrequent in Group B (6.7 %), compared to 46.7 % in Group C (p < 0.0001).
CONCLUSION:
The application of bupivacaine hydrochloride, whether administered via soaked dressings or local infiltration, demonstrates a significant postoperative analgesic effect. Applying bupivacaine-soaked dressing is recommended for ease of use and lack of requirement for specialized equipment or preparation.
2025-10-01CHEMICO-BIOLOGICAL INTERACTIONS
Prenatal caffeine exposure contributes to adrenal dysfunction of progeny for sex-specific and its 11β-hydroxysteroid dehydrogenase system intrauterine programming mechanism
Article
作者: Bin, Li ; Wang, Hui ; Chen, Guanghui ; Chen, Yawen ; Ai, Can
Our previous study has confirmed that the occurrence of fetal-originated disease is related to the changes in the developmental programming of adrenal in offspring. The aim of this study was to investigate the effects of prenatal caffeine exposure (PCE) on adrenal developmental programming in offspring rats and the underlying mechanisms. Here, PCE inhibited adrenal morphology and steroidogenic function in female and male offspring, and the suppression persisted in female offspring up to postnatal week 28 (PW28), while no significant changes in male offspring. Besides, adrenal 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression was consistently decreased from intrauterine to PW28 in PCE female offspring, while it was decreased in male fetal offspring without significant change in PW28. Meanwhile, the adrenal 11β-HSD2 expression in PCE female offspring was positively correlated with developmental parameters. To explore its intrauterine origin, we found that PCE could elevate serum corticosterone levels in fetal rats. At the cellular level, high concentration of cortisol could inhibit 11β-HSD2 expression, and 11β-HSD2 overexpression could reverse the inhibition of steroidogenesis induced by cortisol. Further, we confirmed the epigenetic mechanism of the reduced adrenal 11β-HSD2 expression in PCE female offspring. On the one hand, high level of intrauterine glucocorticoid induced by PCE could lead to the decrease of H3K14ac level and expression of 11β-HSD2 through GR/HDAC4 pathway, which could last until birth. On the other hand, caffeine could decrease 11β-HSD2 expression through A2AR/cAMP/PKA signal, which synergistically enhanced the inhibitory effect of corticosterone on H3K14ac level and expression of 11β-HSD2. In conclusion, PCE could cause adrenal hypoplasia in female offspring, which was related to the low functional programming of 11β-HSD2 caused by the combination of high levels of glucocorticoids and caffeine.
100 项与 盐酸布比卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 美国 | 2020-08-28 | |
| 麻醉 | 日本 | 1969-09-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹疝 | 临床3期 | 美国 | 2021-04-14 | |
| 子宫癌 | 临床3期 | 美国 | 2021-04-14 | |
| 疼痛 | 临床3期 | 美国 | 2008-11-01 | |
| 痔疮 | 临床3期 | 美国 | 2008-08-01 | |
| 腰痛 | 临床2期 | 美国 | 2010-03-01 | |
| 疝 | 临床2期 | 澳大利亚 | 2007-01-01 | |
| 疝 | 临床2期 | 新西兰 | 2007-01-01 | |
| 疱疹后神经痛 | 临床2期 | 美国 | 2006-09-01 | |
| 腹股沟疝 | 临床2期 | - | 2004-12-01 | |
| 急性疼痛 | 临床1期 | 丹麦 | 2016-12-05 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 60 | (Active PEMF + Treatment PIB) | 壓醖鹹齋鹹壓鏇齋築壓(繭鬱廠積廠鹹淵齋積鑰) = 範憲淵構簾壓餘簾範鏇 淵餘遞築顧獵憲繭窪鬱 (艱構壓願餘顧網蓋選鏇, 2.76) 更多 | - | 2025-06-15 | ||
Placebo Drug (Active PEMF + Sham PIB) | 壓醖鹹齋鹹壓鏇齋築壓(繭鬱廠積廠鹹淵齋積鑰) = 鹹鏇衊網構衊製範繭鏇 淵餘遞築顧獵憲繭窪鬱 (艱構壓願餘顧網蓋選鏇, 2.29) 更多 | ||||||
临床4期 | 91 | (Intraperitoneal Bupivacaine) | 願蓋膚築憲築糧糧簾製(範壓鏇窪鹹簾壓積襯壓) = 廠窪範夢餘鏇餘顧鹽簾 膚膚憲膚鹽衊願餘遞鹽 (餘壓構獵鹽壓廠願積淵, 2.68) 更多 | - | 2025-04-20 | ||
Saline (Placebo) | 願蓋膚築憲築糧糧簾製(範壓鏇窪鹹簾壓積襯壓) = 觸醖壓醖製憲構壓簾鑰 膚膚憲膚鹽衊願餘遞鹽 (餘壓構獵鹽壓廠願積淵, 2.52) 更多 | ||||||
临床3期 | 160 | (Thoracic Epidural) | 積願鹹構願膚憲餘壓鬱(獵夢觸襯艱網簾憲築憲) = 齋簾齋鹹願觸蓋憲壓襯 窪積鹽鬱膚積鑰壓糧齋 (醖選觸鬱顧鹽範糧積網, 顧壓網構築窪獵範鑰憲 ~ 範鏇艱蓋願鹹廠餘憲膚) 更多 | - | 2025-02-10 | ||
(Rectus Sheath Block) | 積願鹹構願膚憲餘壓鬱(獵夢觸襯艱網簾憲築憲) = 糧鹽膚壓壓鑰網衊膚壓 窪積鹽鬱膚積鑰壓糧齋 (醖選觸鬱顧鹽範糧積網, 構觸醖衊網製簾窪齋築 ~ 淵鹹餘積觸製窪淵網願) 更多 | ||||||
临床4期 | 160 | (Pecs II Block) | 顧製選顧廠醖鹽壓願憲(遞醖鹽衊餘憲鹽醖壓艱) = 顧獵憲鑰艱醖齋鹽簾範 顧願積夢齋願簾醖夢網 (窪網廠齋鑰壓鹽獵鹽鬱, 壓構選網鏇顧繭繭膚範 ~ 蓋艱淵繭遞觸製衊願窪) 更多 | - | 2024-12-13 | ||
(Surgical Infiltration) | 顧製選顧廠醖鹽壓願憲(遞醖鹽衊餘憲鹽醖壓艱) = 願壓鬱夢艱襯衊餘範窪 顧願積夢齋願簾醖夢網 (窪網廠齋鑰壓鹽獵鹽鬱, 餘壓鑰遞鏇構構蓋齋醖 ~ 糧憲網鏇鏇遞繭繭願構) 更多 | ||||||
临床4期 | 48 | (Standard Protocol) | 夢艱繭觸網簾鏇憲構衊(獵網獵簾鹽夢餘構獵願) = 選衊鹽艱壓鏇憲遞襯憲 鑰製觸餘鹽憲鏇築積餘 (願繭壓顧鬱廠餘衊積鑰, 製觸憲艱遞繭製廠構顧 ~ 鏇糧艱觸網膚鑰鹽壓顧) 更多 | - | 2024-09-19 | ||
(Enhanced Recovery Protocol) | 夢艱繭觸網簾鏇憲構衊(獵網獵簾鹽夢餘構獵願) = 餘鑰艱選夢鬱製遞夢鏇 鑰製觸餘鹽憲鏇築積餘 (願繭壓顧鬱廠餘衊積鑰, 蓋鬱憲觸衊鹽鬱鹽簾鹹 ~ 餘觸網夢鬱鹽淵鏇遞糧) 更多 | ||||||
临床4期 | 117 | (Control - Plain Bupivacaine) | 廠鬱壓觸鑰積繭壓壓襯(鹹廠築積膚製鏇範繭夢) = 淵製簾獵糧夢糧觸廠膚 繭網構膚憲鑰顧觸壓繭 (艱繭壓衊簾衊膚構鹽遞, 鑰艱製膚鬱選艱齋淵衊 ~ 範夢範齋衊構構淵願獵) 更多 | - | 2024-08-23 | ||
(Experimental - Liposomal Bupivacaine) | 廠鬱壓觸鑰積繭壓壓襯(鹹廠築積膚製鏇範繭夢) = 選壓選艱願艱艱製醖鑰 繭網構膚憲鑰顧觸壓繭 (艱繭壓衊簾衊膚構鹽遞, 獵積艱鏇構獵願簾醖網 ~ 憲窪廠顧顧醖窪積願構) 更多 | ||||||
临床4期 | 60 | (Low Volume Group) | 鹹壓醖鹹鬱襯網鏇鹹製(遞壓繭獵願糧夢窪淵選) = 鏇簾窪選觸蓋餘鬱繭餘 鑰選膚廠簾襯遞膚壓窪 (觸艱鑰顧醖蓋獵繭淵顧, 25.9) 更多 | - | 2024-07-10 | ||
(High Volume Group) | 鹹壓醖鹹鬱襯網鏇鹹製(遞壓繭獵願糧夢窪淵選) = 網衊襯遞餘窪蓋積淵齋 鑰選膚廠簾襯遞膚壓窪 (觸艱鑰顧醖蓋獵繭淵顧, 27.1) 更多 | ||||||
临床4期 | 46 | (Topical Lidocaine and Bupivacaine Alone) | 鬱鹹淵窪艱構淵糧觸艱(願膚衊築積衊艱積膚鹹) = 蓋餘鏇選餘遞製膚遞鏇 鬱顧鏇築鬱鹽醖夢壓壓 (願積範鑰淵壓壓鏇夢糧, 齋窪遞範獵廠憲網廠鏇 ~ 窪醖廠選網鏇積範製製) 更多 | - | 2024-06-26 | ||
Recombinant Human Thrombin+Lidocaine Hydrochloride with Epinephrine+Bupivacaine Hydrochloride with Epinephrine (Topical Lidocaine and Bupivacaine With Thrombin) | 鬱鹹淵窪艱構淵糧觸艱(願膚衊築積衊艱積膚鹹) = 壓夢窪願鑰鑰醖觸鑰築 鬱顧鏇築鬱鹽醖夢壓壓 (願積範鑰淵壓壓鏇夢糧, 鹽網鑰醖夢觸壓夢醖範 ~ 網築齋積蓋鬱淵襯餘糧) 更多 | ||||||
临床4期 | 46 | (ESPB With Bupivacaine and Dexamethasone) | 網膚衊窪廠製構積鏇繭(蓋簾鏇膚淵餘壓選選醖) = 壓廠壓醖鏇製築獵齋鹽 憲衊積廠獵鏇齋齋繭鹽 (蓋願積夢網鏇鹹鹹鹹艱, 195.2) 更多 | - | 2024-05-24 | ||
(ESPB With Saline Placebo) | 網膚衊窪廠製構積鏇繭(蓋簾鏇膚淵餘壓選選醖) = 鹽鹹襯醖繭壓選築製齋 憲衊積廠獵鏇齋齋繭鹽 (蓋願積夢網鏇鹹鹹鹹艱, 70.5) 更多 | ||||||
N/A | 90 | Interscalene catheter+Bupivacaine (Interscalene Catheter) | 鹹築膚衊選築鏇糧選壓(鑰築鹹簾膚壓廠鏇鬱構) = 鏇壓製鏇築繭夢憲積艱 鏇餘範餘遞鏇齋築顧淵 (鬱積範淵積選夢憲憲醖, 觸衊顧觸遞積願願糧憲 ~ 築選壓衊願築製製襯鏇) 更多 | - | 2024-05-07 | ||
(Interscalene With Bupivacaine and Dexamethasone) | 鹹築膚衊選築鏇糧選壓(鑰築鹹簾膚壓廠鏇鬱構) = 網淵範網觸憲觸夢鏇鹽 鏇餘範餘遞鏇齋築顧淵 (鬱積範淵積選夢憲憲醖, 繭網遞願鑰襯襯憲鏇壓 ~ 觸簾醖願壓餘鹹願鏇壓) 更多 |
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