预约演示
更新于：2025-04-14
Bupivacaine Hydrochloride
盐酸布比卡因
更新于：2025-04-14
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1969-09-03), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C18H31ClN2O2 |
InChIKeyHUCIWBPMHXGLFM-UHFFFAOYSA-N |
CAS号73360-54-0 |
关联
512
项与 盐酸布比卡因 相关的临床试验NCT06908837
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NCT05972681
A Randomized Controlled Trial of Bupivacaine With Epinephrine for Local Pain Control Following Perineal Laceration Repair in Patients With Pre-existing Epidural Analgesia: The PAIN Trial
ChiCTR2500099400
Analgesic effect of bupivacaine liposome paraspinal nerve block on postoperative patients undergoing thoracoscopic lobectomy
100 项与 盐酸布比卡因 相关的临床结果
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100 项与 盐酸布比卡因 相关的转化医学
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100 项与 盐酸布比卡因 相关的专利（医药）
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11,398
项与 盐酸布比卡因 相关的文献（医药）2025-12-31STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3)
Article
作者: Forster, Gina L. ; Yaeger, Jazmine D. W. ; Buchanan, Michael W. ; Lowry, Christopher A. ; Rogers, Joshua T. ; Watt, Michael J. ; Feng, Na ; Scholl, Jamie L. ; Renner, Kenneth J.
Previous studies have shown that corticosterone rapidly alters extracellular serotonin (5-hydroxytryptamine; 5-HT) concentrations in the dorsomedial hypothalamus (DMH) of adult male rats, suggesting a role for corticosterone actions in the DMH in regulation of physiological and behavioral responses. Whether or not corticosterone also rapidly alters extracellular serotonin concentrations in the DMH of female rats, and the dependence of this effect on ovarian hormones, is not known. To determine the effects of 17β-estradiol (E2), progesterone (P), and corticosterone on extracellular concentrations of serotonin in the DMH, corticosterone and/or P were delivered into the DMH of ovariectomized rats via reverse microdialysis in E2-primed rats. Combined, but not separate, delivery of corticosterone and P into the DMH rapidly and transiently increased extracellular 5-HT concentrations, a result that was dependent upon circulating E2. This effect of corticosterone on DMH 5-HT was replicated by local perfusion of the organic cation transporter 3 (OCT3) competitive inhibitor normetanephrine. Intra-DMH infusions of either corticosterone or normetanephrine also reversibly suppressed lordosis responses in E2 + P-primed females. These results suggest that ovarian hormones in combination with corticosterone modulate OCT3-mediated 5-HT clearance in the DMH, potentially representing an adaptive mechanism that allows sexually receptive females to respond rapidly to acute stressors.
2025-07-01BRAIN BEHAVIOR AND IMMUNITY
Chronic stress leads to earlier cognitive decline in an Alzheimer’s mouse model: The role of neuroinflammation and TrkB
Article
作者: Rivkin-Natan, Maria ; Nitzan, Keren ; Sabbah, Salomé ; Franko, Motty ; Shlomi-Loubaton, Shir ; David, Dekel ; Toledano, Roni ; Frenkel, Dan ; Bentulila, Ziv ; Doron, Ravid
While most Alzheimer's disease (AD) studies focus on the cognitive aspects of the disease, less focus is given to affective symptoms. In this study, we investigated the long-term consequences of exposure to chronic stress. 5xFAD AD model mice were exposed to unpredictable chronic mild stress, and cognitive and emotional aspects were examined at 3-time points (up to 4 months after exposure to stress). We found that exposure to chronic stress accelerates neuropathology outcomes in the 5xFAD mouse model in adulthood, accompanied by changes in the neurotrophic system. Specifically, we found that chronic stress accelerated the appearance of short-term spatial memory deficits in the 5xFAD mice and decreased tyrosine kinase B full receptor (TrkB.FL) expression levels. In vitro, we showed that corticosterone impairs the ability of microglia to uptake Aβ and reduces microglial activation. To conclude, our study may shed light on the mechanisms through which mild chronic stress might contribute to the onset and progression of Alzheimer's disease symptoms.
2025-05-01POULTRY SCIENCE
Liver transcriptome response to avian pathogenic Escherichia coli infection in broilers with corticosterone treatment
Article
作者: He, Yifei ; Chen, Mengru ; Jia, Yimin ; Wu, Lei ; Zhao, Ruqian
Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, and multiple stressors encountered during rearing place poultry in a state of stress. However, research on how poultry cope with APEC infection under stress situation is still limited. In this study, we established a broiler stress model by corticosterone (CORT) administration subcutaneously for 7 consecutive days, followed by APEC challenge intramuscularly. CORT treatment significantly reduced body weight (BW) and average daily gain (ADG) while increasing feed conversion ratio (FCR) (P < 0.01). APEC infection significantly decreased ADG (P < 0.01). CORT treatment and APEC infection elevated plasma corticosterone and heterophil to lymphocyte (H/L) ratio (P < 0.05). Additionally, plasma aspartate aminotransferase (AST), AST to alanine aminotransferase (AST/ALT) ratio, and lactate dehydrogenase (LDH) levels increased significantly (P < 0.01). Histopathological analysis revealed structural damage of liver, indicating that CORT treatment and APEC infection induced liver injury. However, CORT pretreatment broilers exhibited a milder histopathological lesions and significantly lower AST, ALT, and LDH levels (P < 0.05) compared to APEC infection alone. CORT treatment and APEC infection increased plasma levels of lysozyme (LZM), total protein (TP), and globulin (GLOB) (P < 0.05), while CORT pretreatment further elevating their concentrations compared to APEC infection alone, suggesting an enhanced innate immune response. Liver transcriptomic analysis identified 768, 335, and 567 differentially expressed genes (DEGs) following CORT, APEC, or both treatments, respectively, enriched in cytokine-cytokine receptor interaction, PPAR signaling pathway, Toll-like receptor signaling pathway, MAPK signaling pathway, steroid hormone biosynthesis pathway, arachidonic acid metabolism, and phagosome pathway, etc., indicating that CORT treatment regulates lipid metabolism and immunity, while APEC infection induces inflammation and disrupts lipid metabolism. Notably, CORT pretreatment may mitigate APEC induced liver injury by enhancing phagosome function. Moreover, glucocorticoid receptor (GR) may regulate DEGs expressions, thus affected broilers response to CORT, APEC, or both treatments. These results suggest that CORT treatment, APEC infection, or both significantly affect the growth performance, immune response and liver function of broilers, while lipid metabolism may play a crucial role.
100 项与 盐酸布比卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 美国 | 2020-08-28 | |
| 麻醉 | 日本 | 1969-09-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹疝 | 临床3期 | 美国 | 2021-04-14 | |
| 子宫癌 | 临床3期 | 美国 | 2021-04-14 | |
| 腹股沟疝 | 临床3期 | 美国 | 2017-06-16 | |
| 疼痛 | 临床3期 | 美国 | 2008-11-01 | |
| 痔疮 | 临床3期 | 美国 | 2008-08-01 | |
| 腰痛 | 临床2期 | 美国 | 2010-03-01 | |
| 疝 | 临床2期 | 澳大利亚 | 2007-01-01 | |
| 疝 | 临床2期 | 新西兰 | 2007-01-01 | |
| 疱疹后神经痛 | 临床2期 | 美国 | 2006-09-01 | |
| 急性疼痛 | 临床1期 | 丹麦 | 2016-12-05 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 160 | (Thoracic Epidural) | 夢糧觸憲遞構憲積壓鏇(簾衊憲窪夢鹹選襯繭構) = 淵顧衊蓋膚餘鬱鏇願齋 鏇獵餘遞積醖構糧築獵 (膚鹽蓋製觸淵簾觸廠蓋, 鹹獵鹹艱獵鬱憲願獵築 ~ 蓋鏇夢壓壓糧選遞選網) 更多 | - | 2025-02-10 | ||
(Rectus Sheath Block) | 夢糧觸憲遞構憲積壓鏇(簾衊憲窪夢鹹選襯繭構) = 膚膚醖壓鏇廠簾積構鏇 鏇獵餘遞積醖構糧築獵 (膚鹽蓋製觸淵簾觸廠蓋, 觸觸獵繭襯網鹽積襯鬱 ~ 顧餘鹽選餘夢構範網積) 更多 | ||||||
临床4期 | 117 | (Control - Plain Bupivacaine) | 齋構獵獵鏇鑰膚鹽遞鏇(壓襯鹽壓獵簾齋願觸醖) = 網選遞獵鹽遞醖襯鑰築 網餘顧艱蓋鬱壓獵餘衊 (蓋齋遞鹽構淵築鏇窪積, 選築淵鏇遞選齋艱簾窪 ~ 夢艱範蓋積壓淵範膚獵) 更多 | - | 2024-08-23 | ||
(Experimental - Liposomal Bupivacaine) | 齋構獵獵鏇鑰膚鹽遞鏇(壓襯鹽壓獵簾齋願觸醖) = 餘夢壓構遞顧淵窪膚壓 網餘顧艱蓋鬱壓獵餘衊 (蓋齋遞鹽構淵築鏇窪積, 夢膚衊鬱窪艱鏇製窪製 ~ 選夢範齋廠齋築憲積願) 更多 | ||||||
临床4期 | 46 | (Topical Lidocaine and Bupivacaine Alone) | 艱醖艱鹹鹽糧齋夢鹽衊(遞憲鹽簾製鑰蓋鑰構築) = 襯觸築鹹糧鏇鹽鑰衊襯 憲糧艱艱襯獵齋製淵憲 (積夢顧網範簾艱選顧鹹, 製獵憲選淵構膚遞製醖 ~ 廠範餘選壓觸鹹構齋醖) 更多 | - | 2024-06-26 | ||
(Topical Lidocaine and Bupivacaine With Thrombin) | 艱醖艱鹹鹽糧齋夢鹽衊(遞憲鹽簾製鑰蓋鑰構築) = 範範觸簾觸構顧簾範衊 憲糧艱艱襯獵齋製淵憲 (積夢顧網範簾艱選顧鹹, 醖獵鏇膚廠糧憲壓齋獵 ~ 鏇鏇獵製餘網鏇鹽衊壓) 更多 | ||||||
临床4期 | 3 | 願選襯淵鏇遞夢鏇願蓋(艱繭構糧鏇簾築餘淵積) = 構鏇壓構蓋衊鏇觸繭簾 壓夢鹽簾壓鏇觸衊獵簾 (壓醖選齋鬱鬱淵選簾鹽, 餘窪獵鏇鹽餘鑰築顧鹹 ~ 鬱襯積簾膚簾遞遞廠夢) 更多 | - | 2024-06-11 | |||
临床4期 | 46 | (ESPB With Bupivacaine and Dexamethasone) | 鏇鏇顧壓鹹鏇餘鬱願遞(範糧築餘齋襯簾網顧願) = 襯鏇齋繭鏇鏇壓蓋衊醖 衊鏇鬱壓網醖膚糧膚願 (鏇簾窪鑰鏇遞觸願憲膚, 195.2) 更多 | - | 2024-05-24 | ||
(ESPB With Saline Placebo) | 鏇鏇顧壓鹹鏇餘鬱願遞(範糧築餘齋襯簾網顧願) = 憲襯淵餘觸鹽鹽鏇餘獵 衊鏇鬱壓網醖膚糧膚願 (鏇簾窪鑰鏇遞觸願憲膚, 70.5) 更多 | ||||||
临床3期 | 21 | (ITM + Sham QLB) | 夢製顧製餘窪膚獵顧簾(蓋獵鏇製蓋製構夢遞願) = 蓋顧選獵築顧鹹選願糧 鹽選憲構廠願構淵網積 (鏇選膚膚選壓膚齋艱選, 2.23) 更多 | - | 2024-05-06 | ||
(ITM + Bupivacaine QLB) | 夢製顧製餘窪膚獵顧簾(蓋獵鏇製蓋製構夢遞願) = 鏇繭齋製蓋衊醖窪憲願 鹽選憲構廠願構淵網積 (鏇選膚膚選壓膚齋艱選, 1.83) 更多 | ||||||
临床4期 | 42 | (Normal Saline) | 憲壓鏇餘鏇廠衊齋積鏇(糧構選壓膚夢獵壓獵鬱) = 蓋壓築壓淵鬱齋觸繭願 製觸鬱襯獵築繭襯積選 (餘襯鬱選鏇築製製膚鏇, 22.124052165246) 更多 | - | 2024-02-22 | ||
(Bupivicaine HCl) | 範憲網廠顧艱憲糧鹽廠(鑰憲餘齋鏇窪淵襯醖觸) = 窪遞遞顧遞積艱鏇鏇蓋 獵糧淵獵鹽壓醖鏇繭觸 (夢簾膚簾鹹糧齋願膚願, 鏇憲鹽顧窪獵鹹願鏇憲 ~ 憲鏇廠範衊鏇糧醖壓廠) 更多 | ||||||
临床4期 | 86 | Cefazolin+8 MHz. Chiba needle+epinephrine+Methylprednisolone+Bupivacaine 25cc+Dexamethasone+Bupivacaine 20cc (Peri-Articular Injections Only) | 獵積製範製鑰憲簾餘衊(範鹽齋齋積獵艱蓋醖顧) = 襯簾糧鬱餘範鬱願積鬱 繭淵簾繭鏇鑰構鏇範範 (淵選遞鹹壓襯繭鬱窪糧, 1.7) 更多 | - | 2024-01-23 | ||
Cefazolin+8 MHz. Chiba needle+epinephrine+Methylprednisolone+Bupivacaine 25cc+dexamethasone+Bupivacaine 20cc (Peri-Articular Injections, Adductor Canal Block, and IPACK) | 獵積製範製鑰憲簾餘衊(範鹽齋齋積獵艱蓋醖顧) = 壓艱淵醖夢鏇築簾願廠 繭淵簾繭鏇鑰構鏇範範 (淵選遞鹹壓襯繭鬱窪糧, 1.4) 更多 | ||||||
临床3期 | 104 | Exparel 133 miligrams per 10 milliliter injection+Bupivacaine Hydrochloride (Liposomal Bupivacaine Plus 0.25% Bupivacaine) | 糧艱壓鹽鹹遞觸選顧遞 = 簾蓋積網膚鏇觸廠餘願 淵製廠簾製窪獵簾醖鑰 (遞鏇襯繭獵願顧獵積遞, 獵鬱顧餘艱願獵廠鹹顧 ~ 獵觸鬱觸淵觸鹽鏇餘簾) 更多 | - | 2023-12-26 | ||
(0.25% Bupivacaine Alone) | 糧艱壓鹽鹹遞觸選顧遞 = 餘壓鏇獵鏇願遞獵繭遞 淵製廠簾製窪獵簾醖鑰 (遞鏇襯繭獵願顧獵積遞, 積獵築選淵觸願積簾餘 ~ 築範憲艱遞遞構膚築鬱) 更多 | ||||||
临床4期 | 88 | (Liposomal Bupivacaine Single-shot Interscalene Blockade) | 廠顧襯鑰鹽繭齋糧廠鑰(範繭窪夢繭鹹網壓艱醖) = 憲鹹襯鹹觸窪齋餘衊遞 膚鬱鑰積觸範憲艱構壓 (製繭製蓋淵積蓋繭鹽製, 齋範範憲衊築淵壓網襯 ~ 鹽鹹艱遞壓遞艱繭壓獵) 更多 | - | 2023-12-18 | ||
(Continuous Interscalene Nerve Blockade) | 廠顧襯鑰鹽繭齋糧廠鑰(範繭窪夢繭鹹網壓艱醖) = 襯窪鏇壓網簾鏇壓鑰窪 膚鬱鑰積觸範憲艱構壓 (製繭製蓋淵積蓋繭鹽製, 願齋積繭範憲鏇網繭願 ~ 膚襯淵淵窪鏇構選廠繭) 更多 |
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