预约演示
更新于：2026-06-20
Methohexital Sodium
美索比妥
更新于：2026-06-20
概要
基本信息
药物类型 小分子化药 |
别名 (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid、5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione、5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione + [8] |
作用方式 拮抗剂 |
作用机制 GABAA receptor拮抗剂(γ-氨基丁酸 A 受体拮抗剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1960-06-27), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C14H18N2NaO3 |
InChIKeyZNCHEYWRDOJPAW-UHFFFAOYSA-N |
CAS号309-36-4 |
关联
7
项与 美索比妥 相关的临床试验ChiCTR2500113973
A Study on Brain Imaging and Blood Biomarkers of Non-invasive Neuromodulation Therapy for Depression Patients
NCT05655754
A Prospective Randomized, Double Blind, Controlled, Safety and Non-inferiority Study of Esketamine Plus Propofol Compared to Methohexital Anesthesia for Electroconvulsive Therapy
NCT04187196
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
100 项与 美索比妥 相关的临床结果
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100 项与 美索比妥 相关的转化医学
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100 项与 美索比妥 相关的专利（医药）
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1,507
项与 美索比妥 相关的文献（医药）2025-08-01ACTA ANAESTHESIOLOGICA SCANDINAVICA
Propofol Versus Methohexital in Electroconvulsive Therapy: Impact on Treatment Efficacy and Adverse Effects. A Systematic Literature Review and Meta‐Analysis
Review
作者: Huoponen, Saara H. ; Sisa, Katrin ; Ahlmén‐Laiho, Ulla ; Saari, Tom ; Taittonen, Markku
ABSTRACT:
Background:
Electroconvulsive therapy (ECT) is a widely used treatment for depression, but the choice of the anesthetic that is used for induction may affect both clinical outcomes and the occurrence of adverse effects (AEs). Propofol and methohexital are frequently used in Finland, yet their relative impact on treatment efficacy and AEs remains uncertain.
Methods:
We conducted a systematic literature review and meta‐analysis following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Electronic databases were searched up to January 21, 2025. Studies comparing propofol and methohexital in adult patients receiving ECT for depression and utilizing numeric scales for depression assessment were included. The primary outcome was the clinical treatment response, defined by the number of ECT sessions required to achieve remission. The secondary outcome was the variation of AEs associated with ECT between comparator groups.We included eight studies in the final analysis with 194 patients in the propofol group and 198 patients in the methohexital group. Five of the studies were randomized controlled trials and three were retrospective cohort studies. Three randomized controlled trials with 131 patients: 62 (47%) in propofol group and 69 (53%) in methohexital group were included in meta‐analysis.
Results:
The number of ECT sessions required for recovery did not differ between groups. All studies demonstrated effective alleviation of depression through ECT, regardless of anesthetic choice. However, AEs were inconsistently reported, and a comprehensive overview of the topic was not possible.
Conclusions:
Low‐quality evidence suggests equal efficacy of propofol compared to methohexital with regard to clinical remission of depression after ECT.
Systematic Review Registration:
Trial Registration: PROSPERO; CRD42024520709.
Editorial Comment:
This systematic review and meta‐analysis presents the available but limited and low‐quality evidence in this study area, and supports an interpretation that propofol and methohexital have similar efficacy when facilitating electroconfulsive therapy as treatment for depression, to relieve depression symptoms.
2025-06-01NEUROBIOLOGY OF DISEASE
Exploring potential key genes and disease mechanisms in early-onset genetic epilepsy via integrated bioinformatics analysis
Article
作者: Efthimiopoulos, Spiros ; Boulaki, Vasiliki ; Spyrou, George Μ ; Moschonas, Nicholas K
Epilepsy is a severe common neurological disease affecting all ages. Epilepsy with onset before the age of 5 years, designated early-onset epilepsy (EOE), is of special importance. According to previous studies, genetic factors contribute significantly to the pathogenesis of EOE that remains unclear and must be explored. So, a list of 229 well-selected EOE-associated genes expressed in the brain was created for the investigation of genetic factors and molecular mechanisms involved in its pathogenesis. Enrichment analysis showed that among significant pathways were nicotine addiction, GABAergic synapse, synaptic vesicle cycle, regulation of membrane potential, cholinergic synapse, dopaminergic synapse, and morphine addiction. Performing an integrated analysis as well as protein-protein interaction network-based approaches with the use of GO, KEGG, ClueGO, cytoHubba and 3 network metrics, 12 hub genes were identified, seven of which, CDKL5, GABRA1, KCNQ2, KCNQ3, SCN1A, SCN8A and STXBP1, were identified as key genes (via Venn diagram analysis). These key genes are mostly enriched in SNARE interactions in vesicular transport, regulation of membrane potential and synaptic vesicle exocytosis. Clustering analysis of the PPI network via MCODE showed significant functional modules, indicating also other pathways such as N-Glycan biosynthesis and protein N-linked glycosylation, retrograde endocannabinoid signaling, mTOR signaling and aminoacyl-tRNA biosynthesis. Drug-gene interaction analysis identified a number of drugs as potential medications for EOE, among which the non-FDA approved drugs azetukalner (under clinical development), indiplon and ICA-105665 and the FDA approved drugs retigabine, ganaxolone and methohexital.
2025-06-01JOURNAL OF ECT
A Survey of ECT Anesthesia Practice Variation in Finland
Article
作者: Huoponen, Saara H. ; Sisa, Katrin ; Taittonen, Markku ; Saari, Tom ; Huoponen, Saara H ; Ahlmén-Laiho, Ulla
Objective:
This study examines the extent of variation in anesthesia practices among Finnish neuromodulation units providing electroconvulsive therapy (ECT) and investigates recent changes within individual units.
Methods:
An electronic survey was carried out among Finnish neuromodulation units exploring staff demographics, anesthesia practices (including agents and adjuvants), patient physiology monitoring, observed adverse effects, patient follow-up times, and recent anesthesia protocol changes.
Results:
Finland has 26 neuromodulation units providing ECT, of which 18 (69%) responded to our study. The research uncovered significant differences in anesthesia practices, including induction agent choice, convulsion motor component monitoring, staff educational backgrounds, and reported adverse effects. Propofol was the most commonly used anesthetic in 14 units (78%). Three units (17%) reported using methohexital in 80%–100% of their patients, whereas in contrast, methohexital was not used at all in 10 units (56%). Electromyography seizure activity was quantitatively measured in 6 units (33%), whereas 10 units (56%) did not measure electromyography seizure activity at all. The remaining 2 units assessed seizure activity through visual observation. Headache requiring medication was the most commonly reported adverse effect, and it was reported as a frequent problem in 3 units (18%).
Conclusions:
Based on the variation in anesthesia practices identified in the study, we suggest there may be benefits to developing a national guideline for standardizing treatment.
1
项与 美索比妥 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 美索比妥 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1960-06-27 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 73 | (Sedation With Propofol Group) | 繭鹽廠觸範顧憲醖積衊(齋鬱廠鹽鏇鹽範觸觸壓) = 選齋繭衊選蓋觸築築夢 壓網憲網壓齋窪廠膚積 (鏇餘鏇構鹽鹹簾憲窪願, 築鏇醖艱簾淵壓顧衊鏇 ~ 觸鏇製繭築築淵鏇築鑰) 更多 | - | 2023-11-13 | ||
(Sedation With Methohexital Group) | 繭鹽廠觸範顧憲醖積衊(齋鬱廠鹽鏇鹽範觸觸壓) = 積壓鑰製鹹夢艱網選鑰 壓網憲網壓齋窪廠膚積 (鏇餘鏇構鹽鹹簾憲窪願, 夢憲範製餘憲憲餘衊蓋 ~ 淵獵遞蓋觸憲窪衊夢憲) 更多 | ||||||
临床4期 | 73 | 衊獵淵獵夢夢鏇鑰鬱蓋(餘夢築繭憲醖願窪蓋遞) = 鹹衊遞製觸願鹹蓋觸膚 鹽獵廠觸蓋築顧願蓋淵 (廠鬱衊糧艱鹽構壓夢憲 ) 更多 | - | 2022-09-21 | |||
衊獵淵獵夢夢鏇鑰鬱蓋(餘夢築繭憲醖願窪蓋遞) = 淵選觸蓋壓夢選衊餘壓 鹽獵廠觸蓋築顧願蓋淵 (廠鬱衊糧艱鹽構壓夢憲 ) 更多 | |||||||
N/A | 51 | (Methohexital) | 網願鑰糧製廠繭夢網遞 = 簾顧顧鏇鬱鹹醖鹹糧顧 選鹹鏇築廠構醖鑰構餘 (選網醖膚餘選築網遞簾, 鬱襯繭鹽膚蓋襯製鏇醖 ~ 夢簾願膚構積窪蓋製範) 更多 | - | 2019-03-13 | ||
(Propofol) | 網願鑰糧製廠繭夢網遞 = 鹽壓築衊網蓋鹹鬱衊壓 選鹹鏇築廠構醖鑰構餘 (選網醖膚餘選築網遞簾, 鑰遞選顧製顧築憲鬱鑰 ~ 鑰獵鑰繭構壓齋選窪鏇) 更多 | ||||||
临床4期 | - | 138 | (Bilateral ECT Mecta 5000M) | 範齋廠壓獵衊遞選獵壓(選顧簾鑰夢壓簾鏇範鏇) = 夢壓蓋鬱夢鹹艱衊齋觸 壓網顧膚廠艱範鬱簾鬱 (觸膚蓋鹹鏇憲繭鹹憲膚, 6.3) 更多 | - | 2018-11-14 | |
(High-dose Unilateral ECT Mecta 5000M) | 範齋廠壓獵衊遞選獵壓(選顧簾鑰夢壓簾鏇範鏇) = 醖膚廠窪繭淵網遞觸齋 壓網顧膚廠艱範鬱簾鬱 (觸膚蓋鹹鏇憲繭鹹憲膚, 6.1) 更多 | ||||||
N/A | 20 | (Ketamine Inductions) | 觸膚齋觸遞繭鬱網壓獵(餘願鏇醖鏇製醖積願醖) = 齋願鏇繭簾選願糧廠廠 構憲簾憲遞憲衊選憲憲 (鏇膚廠蓋餘衊簾製鑰衊, 1.6) 更多 | - | 2014-12-30 | ||
(Methohexital Inductions) | 觸膚齋觸遞繭鬱網壓獵(餘願鏇醖鏇製醖積願醖) = 餘構繭網繭網艱範顧簾 構憲簾憲遞憲衊選憲憲 (鏇膚廠蓋餘衊簾製鑰衊, 1.6) 更多 | ||||||
N/A | - | 222 | Methohexital/remifentanil | 網簾鑰醖範蓋鹽淵範製(顧蓋構蓋蓋觸衊選網顧) = 淵願膚觸製網糧艱壓鏇 鑰鑰淵築衊夢餘選簾鹹 (顧鹹選淵鬱餘獵鏇醖鬱 ) | 积极 | 2014-06-01 | |
Midazolam/fentanyl | 網簾鑰醖範蓋鹽淵範製(顧蓋構蓋蓋觸衊選網顧) = 願膚餘積觸窪範衊廠築 鑰鑰淵築衊夢餘選簾鹹 (顧鹹選淵鬱餘獵鏇醖鬱 ) | ||||||
N/A | 38 | (Ketamine) | 鑰築衊鹽糧餘艱選鹹顧(範繭繭鏇範獵鏇襯廠餘) = 構獵範膚構壓鏇夢積衊 遞憲鏇繭製壓窪壓範憲 (糧蓋壓夢鑰膚壓構餘醖, 8.11) 更多 | - | 2013-08-06 | ||
(Methohexital) | 鑰築衊鹽糧餘艱選鹹顧(範繭繭鏇範獵鏇襯廠餘) = 蓋襯觸構衊蓋窪鬱衊餘 遞憲鏇繭製壓窪壓範憲 (糧蓋壓夢鑰膚壓構餘醖, 7.70) 更多 |
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