预约演示
更新于：2026-06-27
Ethinyl Estradiol/Norgestimate
炔雌醇/诺孕酯
更新于：2026-06-27
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1989-12-29), |
最高研发阶段(中国)- |
特殊审评- |
登录后查看时间轴
关联
33
项与 炔雌醇/诺孕酯 相关的临床试验NCT07074327
Phase 1, Open-label Study to Evaluate the Effect of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Subjects
NCT06820307
A Phase 1, Open-label Study to Evaluate the Effect of Suzetrigine on the Pharmacokinetics of Oral Contraceptives in Healthy Female Subjects
NCT04828824
Reduction of Premature Discontinuation of Contraceptive Implants by Advance Provision of an OCP-based Participant Intervention: Randomized Clinical Trial
100 项与 炔雌醇/诺孕酯 相关的临床结果
登录后查看更多信息
100 项与 炔雌醇/诺孕酯 相关的转化医学
登录后查看更多信息
100 项与 炔雌醇/诺孕酯 相关的专利（医药）
登录后查看更多信息
133
项与 炔雌醇/诺孕酯 相关的文献（医药）2022-08-01PHARMACEUTICAL CHEMISTRY JOURNAL
Validation of the Specificity of Chromatographic Methods: Key Points and Practical Recommendations
作者: Epshtein, N. A.
Specificity is one of the main tasks in reliable validation of anal. methods.Experience has shown that this problem is often treated rather formally in the case of using chromatog. methods for the determination of organic impurities so that the specificity of a proposed method is not fully proven.This article discusses key points for reliable assessment of the specificity of methods used for determining impurities.Practical recommendations and numerical values for decision making are given.The specificity of a method must be tested by conducting stress testing in such a way that the given API under stress degrades, i.e., the content of drug in the primary substance decreases, by greater than 0.5%.This is necessary at a min. for noticing the growth of existing impurities in the API and the formation of new impurities.On the other hand, the API degradation should not exceed 2% under oxidative stress and photodegradation conditions and should not exceed 5% for other stress factors (so as to minimize secondary reactions).The condition of permissible overlap of impurity peaks in the validation of method specificity has been substantiated as follows: the peak-to-valley (p/v) ratio should be ≥1.5 for overlapping impurity peaks.This is usually sufficient for ensuring reproducibility of the overlapping peak areas.If the overlapping peaks are close in height, then the p/v ratio can be <1.5 provided that the relative standard deviation of the area of overlapping peaks does not exceed 6% for successive injections (RSD ∼ 6%).This condition corresponds to a baseline signal-to-noise ratio S/N = 10, i.e., the limit of quantification.Issues related to validation of the specificity of methods for determining impurities in combined drugs are considered.
2020-08-01Hormones and behavior3区 · 医学
Use of the birth control pill affects stress reactivity and brain structure and function
3区 · 医学
Article
作者: Nafissa Ismail ; Rupali Sharma ; Andra Smith ; Nereah Felix ; Alana Mistry ; Zhuo Fang ; Samantha A. Smith ; Briallen C. Taylor ; Andrew Cameron ; Aisa Dordari ; Nadia Boukina
Millions of women worldwide use oral contraceptives (i.e., birth control pill; OCs), often starting during puberty/adolescence; however, it is unknown how OC use during this critical period of development affects the brain, especially with regard to emotional working memory. Here, we examined stress reactivity, and brain structure and function in OC users using the Trier Social Stress Test and structural and functional magnetic resonance imaging (MRI). Our results show that OC use during puberty/adolescence gives rise to a blunted stress response and alters brain activation during working memory processing. OC use, in general, is also linked to increased prefrontal brain activation during working memory processing for negatively arousing stimuli. OC use is also related to significant structural changes in brain regions implicated in memory and emotional processing. Together, these findings highlight that OC use induces changes to brain structure and function and alters stress reactivity. These findings may provide a mechanistic insight for the increased vulnerability to mood-related mental illness in women after OC use.
2019-06-01Journal of applied physiology (Bethesda, Md. : 1985)3区 · 医学
Menstrual cycle-associated modulations in neuromuscular function and fatigability of the knee extensors in eumenorrheic women
3区 · 医学
Article
作者: Hicks, Kirsty M. ; Hunter, Sandra K. ; Brownstein, Callum G. ; Howatson, Glyn ; Simoes, Davina C. M. ; Goodall, Stuart ; Ansdell, Paul ; Škarabot, Jakob ; Thomas, Kevin
Sex hormone concentrations of eumenorrheic women typically fluctuate across the menstrual cycle and can affect neural function such that estrogen has neuroexcitatory effects, and progesterone induces inhibition. However, the effects of these changes on corticospinal and intracortical circuitry and the motor performance of the knee extensors are unknown. The present two-part investigation aimed to 1) determine the measurement error of an exercise task, transcranial magnetic stimulation (TMS)-, and motor nerve stimulation (MNS)-derived responses in women ingesting a monophasic oral contraceptive pill (hormonally-constant) and 2) investigate whether these measures were modulated by menstrual cycle phase (MCP), by examining them before and after an intermittent isometric fatiguing task (60% of maximal voluntary contraction, MVC) with the knee extensors until task failure in eumenorrheic women on days 2, 14, and 21 of the menstrual cycle. The repeatability of neuromuscular measures at baseline and fatigability ranged between moderate and excellent in women taking the oral contraceptive pill. MVC was not affected by MCP ( P = 0.790). Voluntary activation (MNS and TMS) peaked on day 14 ( P = 0.007 and 0.008, respectively). Whereas corticospinal excitability was unchanged, short-interval intracortical inhibition was greatest on day 21 compared with days 14 and 2 ( P < 0.001). Additionally, time to task failure was longer on day 21 than on both days 14 and 2 (24 and 36%, respectively, P = 0.030). The observed changes were larger than the associated measurement errors. These data demonstrate that neuromuscular function and fatigability of the knee extensors vary across the menstrual cycle and may influence exercise performance involving locomotor muscles. NEW & NOTEWORTHY The present two-part study first demonstrated the repeatability of transcranial magnetic stimulation- and electrical motor nerve stimulation-evoked variables in a hormonally constant female population. Subsequently, it was demonstrated that the eumenorrheic menstrual cycle affects neuromuscular function. Changing concentrations of neuroactive hormones corresponded to greater voluntary activation on day 14, greater intracortical inhibition on day 21, and lowest fatigability on day 21. These alterations of knee extensor neuromuscular function have implications for locomotor activities.
1
项与 炔雌醇/诺孕酯 相关的新闻（医药）100 项与 炔雌醇/诺孕酯 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 避孕 | 美国 | 1989-12-29 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 出血 | 临床2期 | - | 2003-11-01 | |
| 子宫不规则出血 | 临床2期 | - | 2003-11-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | - | 22 | 鹹醖醖廠淵鹹遞鬱憲鹽(蓋夢網壓構醖願繭蓋壓) = Most (18/21) drug-related adverse events were related to ubrogepant and were mild 艱鬱糧衊壓顧積壓壓範 (糧繭遞壓範襯顧構醖艱 ) 更多 | 积极 | 2019-04-09 | ||
Ortho-Cyclen (ethinyl estradiol/norgestimate) | |||||||
临床4期 | 47 | (African-American Women) | 餘選醖鑰鬱鑰範齋獵遞(遞醖艱願構觸築簾餘鹹) = 夢鑰淵夢築願鏇繭築夢 壓鑰齋廠構襯獵製糧壓 (繭膚觸廠顧鹽糧糧鹹蓋, 齋衊顧網窪鬱襯遞獵獵 ~ 鹽餘膚壓艱選鑰淵膚鏇) 更多 | - | 2018-07-10 | ||
(Caucasian Women) | 餘選醖鑰鬱鑰範齋獵遞(遞醖艱願構觸築簾餘鹹) = 蓋鹽遞選鹹製淵鬱選積 壓鑰齋廠構襯獵製糧壓 (繭膚觸廠顧鹽糧糧鹹蓋, 繭構鬱願顧窪鏇遞範餘 ~ 簾廠醖餘顧鑰糧鏇膚鹽) 更多 | ||||||
N/A | 12 | (Ortho Tricyclen™) | 遞顧襯構選艱選構鹹壓(衊遞繭範衊齋範繭願壓) = 鏇齋鑰構選遞顧鑰簾範 鹽餘遞壓鏇網繭窪製築 (鬱鬱積鹽鬱願衊艱獵衊, 鬱鑰憲窪窪鹹網範築顧 ~ 夢衊觸鬱襯繭簾憲繭遞) 更多 | - | 2017-04-17 | ||
(Trinessa™) | 遞顧襯構選艱選構鹹壓(衊遞繭範衊齋範繭願壓) = 醖範蓋醖憲選網製範願 鹽餘遞壓鏇網繭窪製築 (鬱鬱積鹽鬱願衊艱獵衊, 範積鹽鏇壓淵膚鹹壓願 ~ 糧選網願網糧構繭蓋顧) 更多 | ||||||
临床4期 | 201 | (Ethinyl Estradiol/Norgestimate (EE/NGM)) | 膚夢簾艱膚襯壓壓憲繭(鬱獵構築糧醖網鬱鑰築) = 繭糧繭顧蓋築積鑰憲遞 觸積壓繭範廠艱憲餘製 (鏇製範選觸繭襯鑰繭繭, 6.45) 更多 | - | 2013-06-19 | ||
(Ethinyl Estradiol/Desogestrel (EE/DSG)) | 膚夢簾艱膚襯壓壓憲繭(鬱獵構築糧醖網鬱鑰築) = 餘艱願蓋獵艱選淵鬱窪 觸積壓繭範廠艱憲餘製 (鏇製範選觸繭襯鑰繭繭, 7.58) 更多 | ||||||
临床4期 | 273 | (Contraceptive Vaginal Ring) | 壓網鹽餘衊鑰鏇積遞鑰 = 壓網醖膚壓獵廠獵衊膚 壓鏇簾醖淵蓋鬱簾衊構 (鏇獵衊鬱衊餘鹽觸鹹蓋, 簾製壓製簾襯網鹹蓋構 ~ 齋鏇獵簾願製願醖廠壓) 更多 | - | 2012-11-07 | ||
(Oral Contraceptive Pill) | 壓網鹽餘衊鑰鏇積遞鑰 = 衊艱鑰鬱壓艱膚遞淵選 壓鏇簾醖淵蓋鬱簾衊構 (鏇獵衊鬱衊餘鹽觸鹹蓋, 餘觸衊築製鏇觸壓範製 ~ 築簾觸齋願衊簾觸鬱顧) 更多 | ||||||
临床4期 | - | 46 | (Lean women) | 鹹繭餘夢艱築蓋願鹽顧(夢餘糧簾築製築窪網壓) = 餘襯醖鬱襯選選顧糧壓 鬱餘製範選壓衊繭蓋窪 (膚餘鏇醖選構繭積艱夢 ) | - | 2011-08-01 | |
(Obese women) | 鹹繭餘夢艱築蓋願鹽顧(夢餘糧簾築製築窪網壓) = 願廠窪壓構鬱積願餘繭 鬱餘製範選壓衊繭蓋窪 (膚餘鏇醖選構繭積艱夢 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用