更新于：2024-11-26
Calcium Chloride Hydrate
氯化钙
更新于：2024-11-26
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式CaCl2H4O2 |
InChIKeyLLSDKQJKOVVTOJ-UHFFFAOYSA-L |
CAS号10035-04-8 |
关联
14
项与 氯化钙 相关的临床试验Post Operative Atrial Fibrillation: Alleviation by Calcium Chloride Injection Into Cardiac Ganglionic Plexus During Coronary Artery Bypass Grafting.
Effect of intravenous calcium chloride injection on the amplitude of transcranial motor evoked potential in spine surgery: a pilot study
Efficacy of intravenous calcium chloride plus oxytocin vs oxytocin alone for the prevention of blood loss during caesarean delivery: A randomized controlled trial. - NIL
100 项与 氯化钙 相关的临床结果
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100 项与 氯化钙 相关的转化医学
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100 项与 氯化钙 相关的专利（医药）
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1,978
项与 氯化钙 相关的文献（医药）2025-02-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Engineering Robust Silver-Decorated calcium peroxide Nano-Antibacterial Platforms for chemodynamic enhanced sterilization
Article
作者: Liang, Xuexue ; Niu, Chunhua ; Guo, Xuhong ; Chen, Kai ; Bai, Ge ; Bohinc, Klemen ; Feng, Yulong ; Wei, Zhong ; Li, Lan
Calcium peroxide (CaO2) is commonly used as a hydrogen peroxide (H2O2) donor to eliminate bacterial infections. However, the rapid dissociation of CaO2 and the explosive release of H2O2 have limited the development of CaO2 in the antibacterial field. Therefore, a series of silver nanoparticles (AgNPs) functionalized bacteria-triggered smart hydrogels (CSA-H) that integrate sustained release of nanoparticles and localized chemodynamic sterilization were constructed. The pH-responsive hydrogel formed through the Schiff base reaction enables the responsive release of CaO2 nanoparticles while simultaneously regulating the concentration of H2O2 within the bacterial infection microenvironment. AgNPs are capable of reacting with H2O2 under mildly acidic conditions to produce hydroxyl radicals with enhanced antimicrobial activity. The antimicrobial results demonstrated that AgNPs functionalized silicon dioxide-coated calcium peroxide (CaO2@SiO2/AgNPs) nanoparticles exhibited enhanced bactericidal activity compared to AgNPs or CaO2 alone. Furthermore, CSA-H hydrogels exhibited significant antibacterial activity against S. aureus and E. coli under the dual effect of AgNPs and pH-driven Fenton-like reactions. This chemodynamic antibacterial platform is environmentally responsive and provides a promising strategy for creating multifunctional hydrogels loaded with nano-enzymes, thus advancing the development of AgNPs in chemodynamic-antibacterial related applications.
2025-01-01BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Involvement of aquaporins in Shiga toxin-induced swelling and water transport dysfunction in human renal microvascular endothelial cells
Article
作者: Girón Reyes, Daniel C ; Damiano, Alicia E. ; Gomez, Fernando D. ; Alvarez, Romina S ; Martínez, Nora A. ; Alvarez, Romina S. ; Reppetti, Julieta ; Amaral, María M. ; Di Giusto, Gisela ; Girón Reyes, Daniel C. ; Gomez, Fernando D ; Balestracci, Alejandro ; Amaral, María M ; Damiano, Alicia E ; Sacerdoti, Flavia ; Martínez, Nora A
One of the hallmarks of Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is kidney damage. Our previous research demonstrated that Shiga toxin type 2 (Stx2a) decreases cell viability and induces swelling of human glomerular endothelial cells (HGEC). However, Stx2a can disrupt net water transport across HGEC monolayers without affecting cell viability. This work aimed to elucidate the possible mechanisms involved in the water transport disruption caused by Stx2a across HGEC monolayers. We investigated paracellular and transcellular water transfer across HGEC by analyzing the passage of FITC-Dextran and the hydrostatic pressure (Phydr) and measuring the osmotic pressure (Posm), respectively. Stx2a selectively affected the transcellular pathway without impacting the paracellular route. Furthermore, Stx2a cell swelling was prevented by pretreatment with aquaporin inhibitors tetraethylammonium chloride (TEA), Mercury (II) chloride (HgCl2) or TGN-020, suggesting aquaporin involvement in this process. Confocal microscopy revealed that Stx2a increased HGEC total volume, which TEA and TGN-020 counteracted. Additionally, we identified in HGEC not only the expression of aquaporin-1 (AQP1) but also the expression of aquaporin-4 (AQP4). Surprisingly, we observed a decrease in the expression of both AQPs after Stx2a exposure. Our findings suggest that Stx2a may induce water movement into HGEC via AQP1 and AQP4, increasing total cell volume. Subsequently, decreased AQP1 and AQP4 expression could inhibit transcellular water transfer, potentially as a protective mechanism against excessive water entry and cell lysis.
2025-01-01FOOD CHEMISTRY
Role of calcium salts in modulating benzo[a]pyrene levels in barbecued pork sausages: A study on quality attributes and safety
Article
作者: Hu, Manzi ; Lu, Jingnan ; Zhou, Hui ; Ding, Honglie ; Xu, Baocai ; Cai, Kezhou ; Mei, Hebao
Benzo[a]pyrene (BaP), known for its carcinogenic and mutagenic properties, is a marker of polycyclic aromatic hydrocarbons (PAHs). This study aimed to investigate the effect of partially replacing sodium chloride with different calcium salts (calcium chloride, calcium gluconate, calcium citrate, and calcium lactate) on BaP formation in barbecued pork sausages. The results revealed that all four calcium salts inhibited BaP formation in barbecued pork sausages (P < 0.05). Specifically, calcium gluconate showed the most significant effect on BaP inhibition, with an inhibition rate of 61.82 %. Furthermore, calcium salts were found to inhibit lipid oxidation in barbecued pork sausages while promoting the Maillard reaction. Further validation experiments used resveratrol and sodium sulfite as lipid oxidation and Maillard reaction inhibitors, respectively. These results indicated that lipid oxidation is the primary pathway for BaP production in barbecued pork sausage and that the addition of calcium salts can effectively block this process.
100 项与 氯化钙 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 铅中毒 | 日本 | 1991-07-31 | |
| 骨软化 | 日本 | 1991-07-31 | |
| 低钙血症 | 日本 | 1991-07-31 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 120 | (Calcium Chloride) | 艱繭鏇願獵鑰膚構積鬱(觸製鑰壓鹽襯簾觸繭衊) = 選鏇繭襯簾膚壓蓋壓構 繭醖夢顧餘夢窪鏇鬱蓋 (遞鏇顧蓋鏇獵觸顧鏇襯, 艱鬱餘繭衊範襯淵鑰鑰 ~ 顧醖顧齋蓋糧獵選獵膚) 更多 | - | 2024-06-11 | ||
Saline placebo (Saline Placebo) | 艱繭鏇願獵鑰膚構積鬱(觸製鑰壓鹽襯簾觸繭衊) = 簾蓋製鏇廠淵築淵鹽獵 繭醖夢顧餘夢窪鏇鬱蓋 (遞鏇顧蓋鏇獵觸顧鏇襯, 憲網繭鹽壓餘壓顧膚廠 ~ 鹹繭憲獵壓築鹽餘簾構) 更多 | ||||||
临床1/2期 | 40 | 願廠壓蓋鑰衊糧範簾壓(觸觸淵繭窪淵鹹憲鹹簾) = Calcium recipients tolerated the drug infusion well, with no adverse events and an equal incidence of potential side effects in the calcium and placebo groups. 築顧範構遞繭範選簾襯 (選繭襯淵醖築觸鬱選襯 ) 更多 | 积极 | 2022-04-18 | |||
Saline placebo control | |||||||
临床2期 | 397 | (Calcium) | 範衊憲憲醖夢構範網憲(艱襯夢築壓鑰餘窪網獵) = 構餘窪鬱顧簾願製憲鑰 獵鹽壓憲衊醖窪選蓋艱 (衊積製鑰壓鹹鹽繭衊獵, 構淵衊憲製齋鬱繭繭衊 ~ 網淵糧鹹構蓋製廠膚廠) 更多 | - | 2022-02-25 | ||
(Placebo) | 範衊憲憲醖夢構範網憲(艱襯夢築壓鑰餘窪網獵) = 製觸鹽艱夢齋積鑰網廠 獵鹽壓憲衊醖窪選蓋艱 (衊積製鑰壓鹹鹽繭衊獵, 築構廠廠鬱範艱築構襯 ~ 製壓蓋鑰廠餘膚鑰鬱壓) 更多 | ||||||
临床4期 | 8 | Placebo | 鬱糧餘襯壓繭淵襯艱築(鬱壓遞糧糧範獵衊觸製) = 襯壓繭選艱鹽鏇廠衊繭 淵襯範願艱遞餘鬱襯簾 (觸淵膚蓋衊衊壓淵觸餘, 鑰衊夢獵衊遞鑰膚淵糧 ~ 壓艱遞餘齋鏇顧積齋繭) 更多 | - | 2017-05-22 |
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