更新于：2024-05-01
Calcium Chloride Hydrate
氯化钙
更新于：2024-05-01
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式CaCl2 |
InChIKeyUXVMQQNJUSDDNG-UHFFFAOYSA-L |
CAS号10043-52-4 |
关联
13
项与 氯化钙 相关的临床试验Post Operative Atrial Fibrillation: Alleviation by Calcium Chloride Injection Into Cardiac Ganglionic Plexus During Coronary Artery Bypass Grafting.
Calcium Chloride for Prevention of Blood Loss From Uterine Atony During Intrapartum Cesarean Delivery (CALBLOC): a Double Blind, Randomized, Placebo Controlled Trial and Nested Population Pharmacokinetic and Pharmacodynamic Analysis
Calcium for Out-of-Hospital Cardiac Arrest - A Randomized, Double-Blind, Placebo-Controlled Trial
100 项与 氯化钙 相关的临床结果
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100 项与 氯化钙 相关的转化医学
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100 项与 氯化钙 相关的专利（医药）
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1,865
项与 氯化钙 相关的文献（医药）2024-04-01Data in brief
Data on searching for synergy between alcohol and salt to produce more potent and environmentally benign gas hydrate inhibitors.
Article
作者: Anton P Semenov ; Rais I Mendgaziev ; Vladimir A Istomin ; Daria V Sergeeva ; Vladimir A Vinokurov ; Yinghua Gong ; Tianduo Li ; Andrey S Stoporev
In order to systematically study the synergistic effect of gas hydrate inhibition with mixtures of methanol (MeOH) and magnesium chloride (MgCl2), the impact of these compounds on the thermodynamic stability of methane hydrate in the systems of CH4-MeOH-H2O, CH4-MgCl2-H2O, and CH4-MeOH-MgCl2-H2O was experimentally investigated. The pressure and temperature conditions of the three-phase vapor-aqueous solution-gas hydrate equilibrium were determined for these systems. The resulting dataset has 164 equilibrium points within the range of 234-289 K and 3-13 MPa. All equilibrium points were measured as the endpoint of methane hydrate dissociation during the heating stage. The phase boundaries of methane hydrate were identified for 8 systems with MeOH (up to 60 mass%), 5 MgCl2 solutions (up to 26.7 mass%), and 14 mixtures of both inhibitors. Most equilibrium points were measured using a ramp heating technique (0.1 K/h) under isochoric conditions when the fluids were stirred at 600 rpm. It was found that even a 0.5 K/h heating rate for the CH4-MgCl2-H2O system at low salt concentrations, along with all mixed aqueous solutions with methanol, gives results that do not differ from 0.1 K/h, considering the measurement uncertainties. Most measurements for the CH4-MgCl2-H2O system at high salt content were acquired using a step heating technique. The coefficients of the empirical equations approximating the equilibrium points for each inhibitor concentration were defined. The change in the slope parameter of the empirical equation was analyzed as a function of inhibitor content. Correlations that accurately describe the thermodynamic inhibition effect of methane hydrate with methanol and magnesium chloride on a mass% and mol% scale were obtained. The freezing temperatures of single and mixed aqueous solutions of methanol and magnesium chloride were determined experimentally to confirm the thermodynamic consistency of the methane hydrate equilibrium data.
2024-02-20Journal of the science of food and agriculture
Alginate beads loaded with rambutan extract: characterization and stability during in vitro gastrointestinal digestion.
Article
作者: Tanwarat Aksornsri ; Methavee Peanparkdee
BACKGROUND:
The fallen young rambutan fruit are an underrated agricultural-wastes which may contain several bioactive compounds. In this study, the fallen young rambutan fruit was assessed regarding their phenolic contents and antioxidant activities. In order to expand its utilization, rambutan extract-loaded hydrogel beads were developed by basic spherification technique using sodium alginate. The effect of ratios of polymer and extract and different calcium sources were evaluated. The recovery of bioactive compounds from hydrogel beads were determined using in vitro gastrointestinal digestion models.
RESULTS:
A 50% (v/v) of ethanol yielded rambutan extract with high chemical properties. The production of hydrogel beads using ratio of 1:3 with calcium lactate (CL) provided the highest percent of production yield of 122.94%. The hydrogel beads developed using the ratio of 1:3 with combination of calcium lactate and calcium chloride (CC) showed high recovery of phenolic compounds and their antioxidant activity after simulated intestinal digestion, which were greater values compared to unencapsulated extract.
CONCLUSION:
This finding demonstrates that the ratio of wall material to rambutan extract and the calcium sources influence the physical properties, chemical properties, and in vitro gastrointestinal digestion stability of alginate beads. The obtained hydrogel beads may potential application in the food or pharmaceutical industries. This article is protected by copyright. All rights reserved.
2024-02-06ACS omega
Controlled Release of Oxygen from Calcium Peroxide in a Weak Acidic Condition by Stabilized Amorphous Calcium Carbonate Nanocoating for Biomedical Applications.
Article
作者: Daisuke Tomioka ; Satoshi Fujita ; Michiya Matsusaki
Calcium peroxide (CaO2) has recently attracted much attention as an oxygen-releasing biomaterial for tissue engineering. CaO2 has also been used in cancer therapies, such as photodynamic therapy. However, the uncontrollability of oxygen release after immersion in water is a challenge. Furthermore, the nanoscale surface chemistry of CaO2 on the oxygen release properties under cell culture conditions has not been taken into account in these applications. Herein, we report the stabilized amorphous calcium carbonate (ACC) nanocoating on CaO2 in a cell culture medium, which suppressed the reaction between CaO2 and water. Stabilized ACC was produced by the reaction between calcium hydroxide (Ca(OH)2) derived from CaO2 and sodium hydrogen carbonate (NaHCO3) including sodium dihydrogen phosphate (NaH2PO4) in a cell culture medium. In contrast, surface modification of CaO2 by calcium carbonate crystals was difficult due to the crystallization process via dissolution-reprecipitation. Strikingly, ACC-CaO2 showed pH-dependent oxygen release in a cell culture medium probably because of the dissolution of ACC under weak acidic condition. Since the environments in ischemic tissue and cancer are weakly acidic, our findings should be important for understanding and designing properties related to biomaterials and drugs using CaO2.
100 项与 氯化钙 相关的药物交易
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研发状态
| 适应症 | 最高研发状态 | 国家/地区 | 公司 |
|---|---|---|---|
| 铅中毒 | 批准上市 | 日本 更多 | |
| 骨软化 | 批准上市 | 日本 更多 | |
| 低钙血症 | 批准上市 | 美国 更多 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 397 | (Calcium) | 醖廠醖壓獵獵衊鑰簾蓋(廠淵蓋鹹衊窪鏇窪遞醖) = 鹽鹹衊構鏇鑰遞鬱觸膚 蓋蓋鑰鏇餘築艱齋構築 (製鹽壓鏇觸願艱繭鏇衊, 蓋鏇築構遞觸淵鹹築糧 ~ 齋夢構範簾鏇繭簾憲夢) 更多 | - | 2022-02-25 | ||
(Placebo) | 醖廠醖壓獵獵衊鑰簾蓋(廠淵蓋鹹衊窪鏇窪遞醖) = 襯遞範醖繭鏇憲網艱鏇 蓋蓋鑰鏇餘築艱齋構築 (製鹽壓鏇觸願艱繭鏇衊, 鬱網膚蓋鏇鑰鏇齋鹽獵 ~ 鏇選餘糧簾夢餘糧顧觸) 更多 | ||||||
临床1/2期 | 40 | (範鏇獵簾鏇選膚糧網糧) = Calcium recipients tolerated the drug infusion well, with no adverse events and an equal incidence of potential side effects in the calcium and placebo groups. 願鹹願淵憲鹽範鏇鬱簾 (淵網鹽選構簾構獵齋鬱 ) 更多 | 积极 | 2022-04-18 | |||
Saline placebo control |
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