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更新于：2025-11-22
Dequalinium Chloride
地喹氯铵
更新于：2025-11-22
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (1996-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C30H40Cl2N4 |
InChIKeyLTNZEXKYNRNOGT-UHFFFAOYSA-N |
CAS号522-51-0 |
关联
9
项与 地喹氯铵 相关的临床试验ChiCTR2500098319
Clinical Observation on the Treatment of Acute Pharyngitis, Tonsillitis, Acute Exacerbation of Chronic Pharyngitis and Other Upper Respiratory Tract Infections Causing Throat Pain and Other Discomforts with Diquichloramine Lozenges: A Randomized Controlled Study
CTR20240880
地喹氯铵含片人体生物等效性研究（预试验）
NCT05788991
Comparative Study of the Efficacy and Safety of Vaginally Applied Dequalinium Chloride (10 mg) and Orally Applied Metronidazole (2 x 500 mg) in the Treatment of Bacterial Vaginosis
100 项与 地喹氯铵 相关的临床结果
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100 项与 地喹氯铵 相关的转化医学
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100 项与 地喹氯铵 相关的专利（医药）
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346
项与 地喹氯铵 相关的文献（医药）2025-11-01NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Nanogel-based delivery of dequalinium chloride: A novel approach for antimicrobial and controlled drug release
Article
作者: Ishtiaq, Syeda Momna ; Sohail, Muhammad Farhan ; Sayyeda, Ammara ; Ahmad, Zulcaif ; Shchinar, Saniia ; Irshad, Asma
Dequalinium chloride (DQC) is a potent antimicrobial agent; however, its therapeutic application is limited due to poor solubility, rapid degradation, and short half-life. In this study, we developed a nanogel-based delivery system to provide stability, bioavailability, and controlled release of DQC, subsequently improving antimicrobial impact. Carbopol 940 and PEG 6000 were used for the synthesis of the nanogel, which was characterized for physicochemical properties, drug entrapment, and release kinetics. Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD) confirmed the successful encapsulation and amorphous nature, whereas Thermogravimetric Analysis (TGA) validated improved thermal stability. The nanogel showed a high entrapment efficiency of 90%, and the drug was released sustained according to a non-Fickian diffusion mechanism with 86.23% cumulative release in 24 h. As per antimicrobial activity, it was observed that the developed formulation showed better inhibition against Escherichia coli and Staphylococcus aureus than free drug solutions. Thus, the findings indicate that the developed nanogel formulation can be considered a worthy advanced antimicrobial delivery system with controlled drug release.
2025-07-01COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Unveiling the role of hydrophobicity and foam property in froth flotation of lepidolite with decamine, dodecylamine, tetradecylamine, hexadecylamine and MIBC
作者: Li, Fangxu ; Liu, Shuo
In order to overcome the limitations of fatty amines (FAS) and reduce consumption and costs, this study developed a high-efficiency flotation system that FAS with Me iso-Bu methanol (MIBC).Single mineral flotation results showed that MIBC enhanced the collecting ability of decamine (DCA), dodecylamine (DDA), tetradecylamine (TDA), and hexadecylamine (HCA) while reducing their dosage.At pH 3, recoveries for DCA, DDA, TDA, and HCA were 63.22 ± 1.34%, 86.284 ± 4.33%, 72.30 ± 3.34%, and 40.02 ± 2.27%, resp.With MIBC added, these increased to 89.43 ± 1.87%, 89.58 ± 2.66%, 73.38 ± 4.27%, and 79.60 ± 2.23%.Batch flotation experiments also demonstrated that lepidolite recovery by DDA and HCA rose from 96.64% and 36.47-96.70% and 98.29%, resp.Surface tension and viscosity detection revealed that the addition of MIBC to FAS resulted in a decrease in surface tension and an increase in solution viscosity.The adsorption, zeta potential, contact angle and foaming property tests indicated that MIBC can enhanced the recovery of lepidolite by adjusting the adsorption densities of DCA and DDA, as well as modifying the bubble properties of TDA and HDA in the flotation pulp.These findings highlighted the critical role of bubble properties in lepidolite flotation systems, going beyond mere hydrophobicity effects.
2025-01-01Research in Pharmaceutical Sciences
The development of mitochondria-targeted quercetin for rescuing Sertoli cells from oxidative stress
Article
作者: Satrialdi ; Pratiwi, Cellina ; Mudhakir, Diky ; Khaeranny, Ryan Novia
Background and purpose::
The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant capacity leads to oxidative stress, which may damage several cellular functions, particularly spermatogenesis. This condition is a leading cause of male infertility, so controlling ROS levels is crucial. The ROS level can be controlled by supporting the endogenous antioxidant system through antioxidant therapy. Mitochondria are the prime target for antioxidant therapy due to the majority of endogenous ROS produced in mitochondria and their critical role in providing energy during fertilization. This research aimed to develop mitochondria-targeted hybrid nanoplatforms by combining liposomes with dequalinium’s mitochondriotropic agent (DQ) to deliver quercetin for targeted antioxidant therapy to mitochondria.
Experimental approach::
The quercetin-loaded nanocarrier was constructed using the hydration method. We varied the concentration of DQ to investigate its impact on physical characteristics, encapsulation efficiency, intracellular trafficking, and in vitro antioxidant activity.
Findings/Results::
The impact of different DQ densities on particle size, encapsulation efficiency, and mitochondria targeting was insignificant. However, lowering the DQ density reduced the zeta potential. Minimizing oxidative stress on TM4 cells was only achieved with low-density DQ (Q-LipoDQ LD), while high-density DQ (Q-LipoDQ HD) failed to mitigate the negative impact.
Conclusion and implications::
According to the findings, LipoDQ LD preserves a promising potential as mitochondria-targeted nanoplatforms and validates the importance of mitochondria as a target for antioxidant therapy.
100 项与 地喹氯铵 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 外阴阴道念珠菌病 | 瑞士 | 2007-05-29 | |
| 细菌性阴道炎 | 瑞士 | 2007-05-07 | |
| 口腔炎 | 中国 | 1996-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 151 | (Dequalinium Chloride) | 廠築製繭襯積廠齋衊壓 = 築廠夢築簾鹽選網網繭 齋築積鏇艱顧積觸醖醖 (衊鏇壓鏇鹹製鏇鑰衊膚, 鏇積構糧顧製襯淵願憲 ~ 壓觸窪餘選窪構齋襯壓) 更多 | - | 2024-10-16 | ||
(Metronidazole) | 廠築製繭襯積廠齋衊壓 = 膚顧蓋鬱餘構選衊築餘 齋築積鏇艱顧積觸醖醖 (衊鏇壓鏇鹹製鏇鑰衊膚, 鏇積窪選衊範餘淵餘憲 ~ 鑰襯鏇蓋鑰餘膚廠襯範) 更多 | ||||||
临床4期 | 147 | 願淵夢簾餘衊蓋獵壓願(糧餘簾齋淵網壓鏇繭簾) = Three patients in the metronidazole group suspended treatment due to an adverse event 膚餘餘積艱鹹範醖廠蓋 (鏇積鹹簾餘鹹醖醖夢積 ) | 积极 | 2024-05-02 | |||
临床4期 | 150 | 構鑰艱製齋鏇艱廠製廠(艱鹽網鹹遞衊獵鹹淵獵): OR = 0.79 (95% CI, 0.56 ~ 1.1), P-Value = 0.197 | - | 2021-01-01 | |||
临床3期 | 321 | Dequalinium Chloride Vaginal Tablets (Fluomizin) | 遞顧窪積鹽夢願繭醖觸(蓋築範醖廠繭選網醖積) = 餘簾窪齋繭齋蓋製積壓 鏇蓋獵遞願獵製夢窪鹽 (製窪壓蓋顧積廠壓觸範 ) 更多 | 积极 | 2012-01-01 | ||
Clindamycin Vaginal Cream | 遞顧窪積鹽夢願繭醖觸(蓋築範醖廠繭選網醖積) = 鹽範艱鏇選糧遞鬱範鹹 鏇蓋獵遞願獵製夢窪鹽 (製窪壓蓋顧積廠壓觸範 ) 更多 |
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