预约演示
更新于：2026-01-03
Dequalinium Chloride
地喹氯铵
更新于：2026-01-03
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (1996-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C30H40Cl2N4 |
InChIKeyLTNZEXKYNRNOGT-UHFFFAOYSA-N |
CAS号522-51-0 |
关联
10
项与 地喹氯铵 相关的临床试验ChiCTR2500098319
Clinical Observation on the Treatment of Acute Pharyngitis, Tonsillitis, Acute Exacerbation of Chronic Pharyngitis and Other Upper Respiratory Tract Infections Causing Throat Pain and Other Discomforts with Diquichloramine Lozenges: A Randomized Controlled Study
CTR20240880
地喹氯铵含片人体生物等效性研究（预试验）
NCT05788991
Comparative Study of the Efficacy and Safety of Vaginally Applied Dequalinium Chloride (10 mg) and Orally Applied Metronidazole (2 x 500 mg) in the Treatment of Bacterial Vaginosis
100 项与 地喹氯铵 相关的临床结果
登录后查看更多信息
100 项与 地喹氯铵 相关的转化医学
登录后查看更多信息
100 项与 地喹氯铵 相关的专利（医药）
登录后查看更多信息
283
项与 地喹氯铵 相关的文献（医药）2025-11-01NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Nanogel-based delivery of dequalinium chloride: A novel approach for antimicrobial and controlled drug release
Article
作者: Ishtiaq, Syeda Momna ; Sohail, Muhammad Farhan ; Sayyeda, Ammara ; Ahmad, Zulcaif ; Shchinar, Saniia ; Irshad, Asma
Dequalinium chloride (DQC) is a potent antimicrobial agent; however, its therapeutic application is limited due to poor solubility, rapid degradation, and short half-life. In this study, we developed a nanogel-based delivery system to provide stability, bioavailability, and controlled release of DQC, subsequently improving antimicrobial impact. Carbopol 940 and PEG 6000 were used for the synthesis of the nanogel, which was characterized for physicochemical properties, drug entrapment, and release kinetics. Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD) confirmed the successful encapsulation and amorphous nature, whereas Thermogravimetric Analysis (TGA) validated improved thermal stability. The nanogel showed a high entrapment efficiency of 90%, and the drug was released sustained according to a non-Fickian diffusion mechanism with 86.23% cumulative release in 24 h. As per antimicrobial activity, it was observed that the developed formulation showed better inhibition against Escherichia coli and Staphylococcus aureus than free drug solutions. Thus, the findings indicate that the developed nanogel formulation can be considered a worthy advanced antimicrobial delivery system with controlled drug release.
2025-07-01COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Unveiling the role of hydrophobicity and foam property in froth flotation of lepidolite with decamine, dodecylamine, tetradecylamine, hexadecylamine and MIBC
作者: Li, Fangxu ; Liu, Shuo
In order to overcome the limitations of fatty amines (FAS) and reduce consumption and costs, this study developed a high-efficiency flotation system that FAS with Me iso-Bu methanol (MIBC).Single mineral flotation results showed that MIBC enhanced the collecting ability of decamine (DCA), dodecylamine (DDA), tetradecylamine (TDA), and hexadecylamine (HCA) while reducing their dosage.At pH 3, recoveries for DCA, DDA, TDA, and HCA were 63.22 ± 1.34%, 86.284 ± 4.33%, 72.30 ± 3.34%, and 40.02 ± 2.27%, resp.With MIBC added, these increased to 89.43 ± 1.87%, 89.58 ± 2.66%, 73.38 ± 4.27%, and 79.60 ± 2.23%.Batch flotation experiments also demonstrated that lepidolite recovery by DDA and HCA rose from 96.64% and 36.47-96.70% and 98.29%, resp.Surface tension and viscosity detection revealed that the addition of MIBC to FAS resulted in a decrease in surface tension and an increase in solution viscosity.The adsorption, zeta potential, contact angle and foaming property tests indicated that MIBC can enhanced the recovery of lepidolite by adjusting the adsorption densities of DCA and DDA, as well as modifying the bubble properties of TDA and HDA in the flotation pulp.These findings highlighted the critical role of bubble properties in lepidolite flotation systems, going beyond mere hydrophobicity effects.
2025-01-01Research in Pharmaceutical Sciences
The development of mitochondria-targeted quercetin for rescuing Sertoli cells from oxidative stress
Article
作者: Satrialdi ; Pratiwi, Cellina ; Mudhakir, Diky ; Khaeranny, Ryan Novia
Background and purpose::
The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant capacity leads to oxidative stress, which may damage several cellular functions, particularly spermatogenesis. This condition is a leading cause of male infertility, so controlling ROS levels is crucial. The ROS level can be controlled by supporting the endogenous antioxidant system through antioxidant therapy. Mitochondria are the prime target for antioxidant therapy due to the majority of endogenous ROS produced in mitochondria and their critical role in providing energy during fertilization. This research aimed to develop mitochondria-targeted hybrid nanoplatforms by combining liposomes with dequalinium’s mitochondriotropic agent (DQ) to deliver quercetin for targeted antioxidant therapy to mitochondria.
Experimental approach::
The quercetin-loaded nanocarrier was constructed using the hydration method. We varied the concentration of DQ to investigate its impact on physical characteristics, encapsulation efficiency, intracellular trafficking, and in vitro antioxidant activity.
Findings/Results::
The impact of different DQ densities on particle size, encapsulation efficiency, and mitochondria targeting was insignificant. However, lowering the DQ density reduced the zeta potential. Minimizing oxidative stress on TM4 cells was only achieved with low-density DQ (Q-LipoDQ LD), while high-density DQ (Q-LipoDQ HD) failed to mitigate the negative impact.
Conclusion and implications::
According to the findings, LipoDQ LD preserves a promising potential as mitochondria-targeted nanoplatforms and validates the importance of mitochondria as a target for antioxidant therapy.
100 项与 地喹氯铵 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 外阴阴道念珠菌病 | 瑞士 | 2007-05-29 | |
| 细菌性阴道炎 | 瑞士 | 2007-05-07 | |
| 口腔炎 | 中国 | 1996-01-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 151 | (Dequalinium Chloride) | 鏇築壓齋製鏇築鏇鏇憲 = 艱鹹憲遞糧範廠夢鏇糧 壓獵構糧壓鬱襯窪構遞 (艱醖齋廠網鏇淵壓淵觸, 衊壓鏇製範夢餘觸觸觸 ~ 窪夢構鹽餘鹽願蓋獵願) 更多 | - | 2024-10-16 | ||
(Metronidazole) | 鏇築壓齋製鏇築鏇鏇憲 = 獵網鹹鏇淵顧蓋廠鏇餘 壓獵構糧壓鬱襯窪構遞 (艱醖齋廠網鏇淵壓淵觸, 製鑰鑰糧觸廠艱糧鏇糧 ~ 顧鏇簾網顧製觸簾範繭) 更多 | ||||||
临床4期 | 147 | 選齋鹽餘壓鹽齋蓋製簾(襯築淵顧製蓋遞獵鏇窪) = Three patients in the metronidazole group suspended treatment due to an adverse event 夢糧鑰製製廠願顧廠網 (鑰夢艱積窪鬱簾簾鹽餘 ) | 积极 | 2024-05-02 | |||
临床4期 | 150 | 蓋齋獵鹹壓齋鹽鏇鹽憲(膚壓遞蓋獵蓋築餘憲鹽): OR = 0.79 (95% CI, 0.56 ~ 1.1), P-Value = 0.197 | - | 2021-01-01 | |||
临床3期 | 321 | Dequalinium Chloride Vaginal Tablets (Fluomizin) | 選夢襯夢蓋鹽願艱網積(醖網築膚鹹網鹹衊遞鏇) = 選淵積簾廠窪壓鹹窪觸 壓鹹鏇選膚觸鹹築窪蓋 (膚蓋醖鑰鏇襯製顧製製 ) 更多 | 积极 | 2012-01-01 | ||
Clindamycin Vaginal Cream | 選夢襯夢蓋鹽願艱網積(醖網築膚鹹網鹹衊遞鏇) = 製衊繭鏇壓糧繭製齋窪 壓鹹鏇選膚觸鹹築窪蓋 (膚蓋醖鑰鏇襯製顧製製 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用