The purpose of this study is to prospectively analyze the value of 3D ultrasound perfusion imaging for treatment planning, the prediction of therapy success, and to monitor the treatment response in patients with a primary or metastatic liver tumor undergoing radiation treatment.

开始日期2014-11-18

申办/合作机构

Stanford University

ChiCTR-TRC-14004912

/ Recruiting临床4期IIT

Perfluorohexane through intratracheal instillation for smoke inhalation injury (SII) study

开始日期2012-05-01

申办/合作机构-

NCT01247740

/ Completed临床3期

A Prospective, Controlled, Randomized, Blinded, Parallel Group Multicentre Study on the Safety and Efficacy of a Convenience Three-chamber Bag for Parenteral Nutrition in Post-operative Patients After Abdominal Surgery Versus a Compounded Monobag

The purpose of the study is to investigate the efficacy and safety of a convenient 3-chamber-bag containing aminoacids, glucose and lipid emulsion (LCT/MCT 20%) compared to a conventionally compounded monobag for parenteral nutrition.

开始日期2010-10-01

申办/合作机构

B. Braun Melsungen AG

100 项与全氟己烷相关的临床结果

登录后查看更多信息

100 项与全氟己烷相关的转化医学

登录后查看更多信息

100 项与全氟己烷相关的专利（医药）

登录后查看更多信息

2,717

项与全氟己烷相关的文献（医药）

2025-07-01·International Journal of Heat and Mass Transfer

Onset of liquid films instability in microchannel flow boiling

作者: Moghaddam, Saeed ; Kriz, Adam

Microchannel flow boiling is becoming increasingly important in many applications, yet its modeling has remained a challenge due to a lack of mechanistic fluid flow models, particularly for thin liquid films.In a recent study, we determined the liquid film thickness and velocity in 300-μm-wide microchannels and used the results to calculate the shear stress at the liquid-vapor interface.A graph of the shear stress vs. the liquid film thickness delineated transition to wavy-annular flow regime.Here, we have extended our studies to different channel sizes and fluids, from low to high surface tension, using a combination of flow boiling and adiabatic test studies.The results show that the onset of films instability is a function of the shear stress at the liquid-vapor interface, consistent with the Kelvin-Helmholtz (K-H) instability.Various criteria for the onset of K-H instability are evaluated.The Richardson number (Ri) as an indicator of the onset of film instability is shown to decrease greatly for thin films in microchannels and is demonstrated to be dependent on surface tension such that Bond number, Bo/Ri for different fluids are relatively close.However, this criterion does not accurately predict the onset of instability of relatively thinner films.Further anal. suggests that Taitel and Dukler's (1976) criterion can accurately predict instability of adiabatic films.However, liquid films in boiling become unstable at a significantly lower interfacial shear stresses relative to Taitel and Dukler's prediction.Addnl. forces and perturbation mechanisms such as evaporative momentum effects, acoustics of nucleate boiling, and local temperature-induced surface tension variations could account for deviations relative to adiabatic films.

2025-06-01·Computers & Chemical Engineering

Operational flexibility-oriented selection of working fluid for organic Rankine cycles via Bayesian optimization

作者: Zhang, Yuxin ; Mei, Chentao ; Zhu, Lingyu ; Wang, Jiayuan

Working fluid selection is a crucial part of organic Rankine cycle (ORC) designs.Traditional selection methods primarily focus on optimizing performance under specific nominal operating conditions, often neglecting potential efficiency losses and feasibility issues that may arise under off-design conditions due to fluctuations in the heat source and sink.This research introduces a novel method for optimizing working fluid selection to achieve robust and efficient operation in the face of environmental variations.Specifically, operational flexibility is analyzed based on the ORC operational model to capture performance deviations from nominal conditions, and is quantified by evaluating the size of the feasible operational region within the uncertain parameter space.Working fluid selection is optimized simultaneously with the cycle configurations, resulting in a computationally challenging mixed-integer nonlinear programming (MINLP) problem, which is addressed through Bayesian optimization.A case study on geothermal brine heat recovery with a recuperative ORC compares flexibility-oriented and conventional working fluid selections, demonstrating a 102% increase in operational flexibility at the cost of an 11.5% efficiency loss.This research underscores the significant impact of working fluid selection on operational flexibility and demonstrates the effectiveness of Bayesian optimization in solving complex MINLP problems for integrated mol.-level and process-level designs.

2025-06-01·Fluid Phase Equilibria

Accurate calculation and reliable prediction of second virial coefficients for nonpolar mixtures

作者: Duan, Yuan-Yuan ; Qin, Kang ; Xu, Liu

The virial equation of state has a theor. advantage in the calculations of mixturesThe second mixture virial coefficients are with the theor. rigid mixing rules and composed of the second virial coefficients for pure fluids and the cross second virial coefficientsBased on the generalized corresponding state principle second virial coefficient model for pure fluids we proposed before, the generalized cross second virial coefficient models were established with three characteristic parameters for nonpolar binaries in this work.The calculation of the mixture critical temperature requires the binary interaction coefficients (k_ij).The mixture acentric factor was determined by the arithmetic mean.The mixture critical pressure could be calculated without the critical sp. volumeFor the most sensitive mixing rule of the mixture critical temperature, the k_ij was optimized for 145 nonpolar binaries.An easily accessible characteristic correlating parameter, the reduced diameter, was proposed to develop the predictive k_ij correlations for common nonpolar binaries.Due to the complex intermol. interactions between two different mols., the k_ij correlations were proposed resp. for alkane/alkane binaries, nonpolar binaries containing fluorocarbon, nonpolar binaries containing nitrogen or oxygen, nonpolar binaries containing simple fluids, nonpolar binaries containing carbon dioxide and nonpolar binaries containing neon.Our work was validated to perform satisfactorily from the comparison with the Chueh-Prausnitz k_ij correlation, Fender-Halsey k_ij correlation, and Meng k_ij correlation.Together with our previous work, this work could accurately calculate and reliably predict the second virial coefficients for common nonpolar mixtures

项与全氟己烷相关的新闻（医药）

2024-09-09

·drugs

Specific PFAS Differentially Affect Maternal Midlife Adiposity

MONDAY, Sept. 9, 2024 -- Specific perfluoroalkyl and polyfluoroalkyl substances (PFAS) measured in early pregnancy differentially affect maternal midlife adiposity, according to a study published online Sept. 5 in the Journal of Clinical Endocrinology & Metabolism . Jordan A. Burdeau, Ph.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues estimated associations of early pregnancy measures of individual PFAS and PFAS mixtures with maternal adiposity in midlife in 547 Project Viva participants. The researchers found that per doubling of perfluorooctane sulfonate (PFOS) and 2-(N-ethyl-perfluorooctane sulfonamido) acetate, linear regression estimated higher midlife weight (3.8 and 2.3 kg, respectively). A positive association was seen between PFOS and midlife adiposity (weight, 7.7 kg), trunk fat mass (1.2 kg), and total body fat mass (3.0 kg) in Bayesian Kernel Machine Regression; inverse associations were seen for perfluorononanoate and perfluorohexane sulfonate. For the overall PFAS mixture, no associations were seen. "If our findings are supported by additional evidence, we may improve understanding of the effects of PFAS on cardiometabolic health during pregnancy, which in turn may improve early prevention or detection of adverse cardiometabolic health outcomes," the authors write.

临床结果

2024-03-16

·生物制品圈

mRNA靶向研究|PD-L1靶向IL-15 mRNA肿瘤免疫治疗

导读：基于PD-1/PD-L1的免疫检查点阻断（ICB）疗法可阻断肿瘤细胞的免疫逃逸，引发抗肿瘤免疫反应。但由于肿瘤内免疫效应细胞浸润不足，通过PD-1/PD-L1 ICB治疗实现的持久有效的免疫应答的患者数较少，因此，在肿瘤免疫微环境中动员免疫效应细胞是促进上述疗法的有效策略。2024年1月，国内学者在Journal of Controlled Release（影响因子10.8）发表文章：《A combination of PD-L1-targeted IL-15 mRNA nanotherapy and ultrasound-targeted microbubble destruction for tumor immunotherapy 》，研究人员开发了一种“DPPA/IL-15 NPs”纳米平台，利用超声靶向微泡破坏技术（UTMD）将白介素-15（IL-15）mRNA靶向递送至PD-L1。该平台通过诱导免疫原性细胞死亡（ICD）和IL-15表达，介导有效的抗肿瘤免疫治疗。01背景介绍白细胞介素-15（Interleukin-15，IL-15）可增殖、募集和激活细胞毒性T淋巴细胞（CTLs）和自然杀伤细胞（NKs），但半衰期短、毒副作用强。因此，将IL-15 mRNA靶向递送至肿瘤细胞可解决上述问题。脂质纳米颗粒（LNPs）是最有效的非病毒递送载体，免疫原性低、生物安全性高、易于合成，可通过优化脂质的组成和比例将mRNA靶向递送至特定器官，但血管畸形和细胞外基质密度高等肿瘤特征限制LNPs的深度渗透。超声（US）介导的药物递送显示出良好的临床前景，可暂时破坏血管内皮屏障促进细胞内化。超声靶向微泡破坏技术（UTMD）可通过增加细胞内活性氧（ROS）介导多种细胞反应，如自噬、上皮-间充质转化和逆转耐药性。已知ROS诱导的内质网（ER）应激是免疫原性细胞死亡（ICD）的前兆，释放的DAMPs显著促进树突状细胞（DCs）的活化和CTLs的募集，DCs激活是肿瘤免疫周期的初始阶段，UTMD有望成为这一步骤的有效刺激剂。基于以上背景，研究人员提出基于UTMD实现免疫检查点靶向的mRNA纳米疗法，研究将其命名为DPPA/IL-15 NPs。其递送系统的特色在于核心成分为全氟己烷（PFH），赋予其超声响应性和超声造影成像性能，同时脂质层存在抗PD-L1肽DPPA修饰。02DPPA/IL-15 NPs的制备、表征和回声性2.1 DPPA/IL-15 NPs的制备PD-L1靶向性LNP递送系统的制备：将100mg DSPE-PEG-NHS溶于3mL DMF中，加入DPPA肽和三乙胺，使其完全溶解并反应12h。将反应液在纯化水中透析24h，透析液冷冻干燥，得DSPE-PEG-DPPA。MC3和PLGA溶于DMF，DSPE-PEG-DPPA溶于无RNase水中（所有试剂使用前超声处理2min）。在pH3.5下，将固定比例的MC3和mRNA加入柠檬酸盐缓冲液中，混合并孵育20min，MC3-mRNA复合物，200μL PFH和250μg PLGA在冰浴条件下超声处理1min。将1mg DSPE-PEG-DPPA水溶液滴加到混合物中并超声处理3min。用无RNase水离心洗涤3次后，收集DPPA/IL-15 NPs并分散到PBS缓冲液中。通过评估发现在相同mRNA质量下，增加MC3可提高转染和翻译效率，当MC3/mRNA质量比为10达到饱和，后续实验MC3/mRNA=10。为探究DPPA/IL-15 NPs的最佳mRNA封装效率，制备分别含有2%、5%、10%、15%、20%和30% MC3的DPPA/IL-15 NPs，发现随MC3含量增加，包封效率逐渐提高，但伴随的溶血速率也增加，为保证生物安全性，后续实验使用10%的MC3。2.2 IL-15 mRNA纳米颗粒的表征IL-15 NPs和DPPA/IL-15 NPs均带负电荷，平均流体动力学尺寸分别为290.8±9.8 nm和325.9±9.4 nm，PDI分别是0.169±0.015和0.139±0.016，表明均匀性高；透射电镜（TEM）显示，DPPA/IL-15 NPs分散良好，粒径主要分布在300nm处；AFM和SEM图像显示DPPA/IL-15 NPs具有完整的球形结构；纳米复合物中mRNA不易被RNase降解，稳定性好；在含10% FBS的培养基中储存48h的DPPA/IL-15 NPs的血清稳定性好，在血液循环过程中可保持稳定。2.3 回声性给药后24h对Cy5-DPPA-NPs和Cy5-NPs的生物分布进行成像和定量，其主要通过肝肾系统代谢。为评估DPPA/IL-15 NPs作为超声造影剂的回声性，使用灰度和CEUS模式获取体外和体内超声图像，静脉注射DPPA/IL-15 NPs后，荷瘤小鼠的US图像在CEUS模式下表现出回声信号和对比增强（p＜0.01），治疗性超声暴露后，肿瘤灌注面积和造影剂强度均较照射前增加（p＜0.05）。因此，DPPA/IL-15 NPs有望在实时超声成像引导下确定肿瘤位置、监测治疗过程和评估治疗效果，实现诊断和治疗的整合。图1 DPPA/IL-15 NPs合成及特征03mRNA递送至肿瘤细胞进行蛋白质翻译免疫细胞分泌的IFN-γ可上调黑色素瘤细胞中的PD-L1，DPPA-NPs与肿瘤细胞上的PD-L1结合效率实验结果发现：PD-L1在IFN-γ处理的B16F10细胞中高表达(83.6%)，经游离DPPA和DPPA-NPs处理后，PD-L1分别下降至24.6%和26.4%，故DPPA-NPs表面的DPPA与PD-L1具有良好的结合能力。进一步探究Cy5-DPPA-NPs的细胞内化及其在US下的增强作用。相较NPs组，DPPA-NPs+US组中cy5阳性细胞比例比DPPA-NPs组高1.15倍，比NPs+US组高1.21倍，表明DPPA-NPs可通过DPPA介导的主动靶向和UTMD介导的超声加工被肿瘤细胞内化。高翻译效率是mRNA有效治疗的基础，研究人员探究DPPA-NPs联合UTMD的翻译效率，与NPs相比，DPPA-NPs介导的主动靶向增强mRNA翻译。DPPA-NPs组与DPPA-NPs+US组观察结果表明增强的mRNA表达受益于US暴露。DPPA-NPs+US组中GFP阳性细胞的数量最多、百分比最高为9618±191#s，96.2±1.9%，DPPA-NPs组和NPs+US组分别为7671±547#s（76.8±5.5%），7220±688#s（72.2±6.8%），荷瘤小鼠模型体内翻译效率与细胞实验结果一致，综上，DPPA/IL15 NPs与UTMD组合可提高翻译效率。图2 UTMD介导的DPPA-NPs mRNA的体外递送IVIS光谱成像系统结果表明UTMD增加了肿瘤部位的药物富集，对肿瘤组织进行解剖发现DPPA-NPs联合UTMD可深度穿透肿瘤。图3 UTMD介导的DPPA-NPs mRNA的体内递送04UTMD诱导ER应激驱动的ICD增强肿瘤免疫原性对于激活抗肿瘤免疫反应至关重要，肿瘤免疫原性可能由死亡的肿瘤细胞引起，称为ICD。采用膜联蛋白V-FITC/PI染色测定UTMD的细胞毒性，单独用US、NPs和DPPA-NPs（无超声）无法诱导显著的细胞凋亡，NPs＋US和DPPA-NPs+US组诱导的细胞凋亡水平明显高于其他组，且出现细胞膜破裂、细胞内容物渗漏和明显的内质网扩张，表明UTMD的声毒性导致细胞凋亡。利用FCM和荧光显微镜评估细胞内ROS的产生，NPs和DPPA-NPs在US照射后均在细胞内产生超氧化物水平的ROS，表明UTMD可诱导氧化应激，且UTMD组中观察到的GRP78高表达表明UTMD在肿瘤细胞内诱导ER应激。内质网中ROS诱导的氧化应激是ICD的先决条件。产生ICD通常伴随着DAMPs的释放，促进DCs的募集和激活，从而触发针对肿瘤细胞的CTLs。进一步探究发现UTMD可诱导内质网应激以触发ICD并驱动多种DAMPs释放，如CRT暴露、HMGB1释放和HSP70增加，综上，UTMD增加了药物向肿瘤部位的递送及肿瘤微环境（TME）中的抗肿瘤免疫反应。图4 UTMD诱导的内质网应激提高DAMPs释放05UTMD联合DPPA/IL-15NPs在体外进行免疫激活为进一步证明UTMD与DPPA/IL-15 NPs在细胞水平上诱导免疫反应的功能，提取小鼠BMDCs，通过门控CD80/CD86阳性细胞评估UTMD联合DPPA/IL-15 NPs对DCs成熟的影响。DPPA/IL-15 NPs+US组的B16F10细胞与BMDCs共培养后成熟DCs（CD11c+CD80+CD86+）的百分比达29.9±0.4%，高于DPPA-NPs+US组（15.0±1.3%）和DPPA/IL-15 NPs组（19.8±1.6%），表明DPPA/IL-15 NPs联合UTMD有效促进DCs成熟。细胞因子分泌对免疫激活很重要，DPPA/IL-15 NPs与UTMD结合后产生的肿瘤细胞碎片触发BMDCs分泌高水平细胞因子（包括IL-6和TNF-α），增强免疫反应。IL-15（促炎细胞因子）可促进T细胞增殖并维持其存活，DPPA/IL15 NPs+US组中的T细胞增殖率高于DPPA/IL-15 NPs组（p＜0.05），与UTMD高效转染IL-15 mRNA有关。NK细胞在无抗原刺激的情况下通过自发裂解肿瘤细胞来消灭它，DPPA/IL-15 NPs+US组NK细胞细胞毒性最高，其次是DPPA/IL-15 NPs组，表明IL-15 mRNA翻译的IL-15在NK细胞中具刺激作用。综上，DPPA/IL-15 NPs与UTMD的结合足以诱导DCs成熟、T细胞增殖并增强NK细胞毒性，具有增强抗肿瘤免疫力的潜力。图5 UTMD联合DPPA/IL-15 NPs的体外免疫激活06UTMD联合DPPA/IL-15 NPs在小鼠体内的免疫作用为评估UTMD与DPPA/IL-15 NPs在B16F10荷瘤小鼠中的联合作用。在第14d切除肿瘤，与对照组相比，DPPA-NPs +US组和DPPA/IL-15 NPs组表现出中度抑制作用，DPPA/IL-15 NPs+US组几乎完全抑制B16F10肿瘤生长，表明联合疗法抑制肿瘤生长。H&E和TUNEL染色评估B16F10肿瘤内的坏死和凋亡，对照组肿瘤细胞结构完整，DPPA-NPs+US、DPPA/IL-15 NPs、DPPA/IL-15 NPs+US组细胞结构丧失、细胞核萎缩及细胞坏死碎裂，DPPA/IL-15 NPs+US组的坏死区明显大于其他组。PD-L1靶向IL-15 mRNA纳米疗法与UTMD联合使用可有效协同，提高抗肿瘤疗效。生物安全是纳米疗法临床应用的前提，UTMD和DPPA/IL-15 NPs组合未引发显著全身毒性及明显病理损伤和炎症浸润，表明组合疗法对活体动物的高度生物安全性。图6 体内原发性B16F10肿瘤的抑制效果07UTMD联合DPPS/IL-15 NPs诱导体内抗肿瘤免疫应答DCs是激活抗肿瘤免疫反应的桥梁，与体外结果一致，DPPA/IL-15 NPs+US组中成熟DCs（CD11c+CD80+CD86+）水平最高（50.0±1.5%），DPPA-NPs、DPPA-NPs+US、DPPA/IL-15 NPs组和对照组分别为26.7±0.9%、31.3±1.7%、38.3±2.3%和22.2±0.6%，表明可能由于UTMD增强IL-15表达，IL-15与死亡肿瘤细胞释放的DAMPs协同作用，启动抗肿瘤免疫反应。CTLs（CD8+ T细胞）是抗肿瘤免疫疗法中的关键效应细胞。DPPA/IL-15 NPs+US组CD8+ T细胞的浸润率(24.1±2.3%)比DPPA-NPs+US组(11.7±1.0%)高2.05倍，比DPPA/IL-15 NPs组(17.6±2.0%)高1.37倍。表明UTMD和DPPA/IL-15 NPs的协同作用导致CTLs有效浸润到B16F10肿瘤中。与其他组相比，DPPA/IL-15 NPs+US组CD8+CD44+ T细胞百分比显著增加，大量肿瘤浸润CD4+ T细胞、CD8+ T细胞及NK细胞，表明联合治疗可系统增强T细胞免疫。与对照组相比，DPPA/IL-15 NPs+US组中IFN-γ、IL6和TNF-α分别高出6.10、3.83和5.42倍，进一步支持联合疗法诱导有效的抗肿瘤免疫反应。综上，UTMD联合DPPA/IL-15 NPs重塑肿瘤免疫微环境，促进免疫杀伤反应。图7 体内全身抗肿瘤免疫分析08UTMD联合DPPS/IL-15 NPs诱导免疫记忆进一步使用转移性肿瘤模型验证抗复发能力。在实验终端收集肺部，对照组观察到大量转移性结节，DPPA/IL-15 NPs+US组中仅观察到散发性转移灶，结合H&E图像结果表明UTMD联合DPPA/IL-15 NPs显著增强抗转移作用。免疫记忆反应是成功适应性免疫的重要标志，采用流式细胞术检测小鼠脾脏中CD8+CD44highCD62Llow效应记忆T细胞(TEM)和CD8+CD44highCD62Lhigh中枢记忆T细胞(TCM)，DPPA/IL-15 NPs+US组CD8+ TEM(28.2±0.5%)和TCM(17.4±0.6%)的百分比高于DPPA-NPs+US组(分别为20.0±0.2%和11.1±0.5%)和DPPA/IL-15 NPs组(分别为25.5±0.8%和12.9±0.8%)，证实联合治疗可诱导稳健的T细胞记忆。综上，UTMD与DPPA/IL-15 NPs联合有利于建立针对复发肿瘤的免疫记忆，作为新的肿瘤治疗途径。图8 免疫治疗转移性B16F10肿瘤的体内研究09小结本研究建立的PD-L1靶向性递送系统DPPA/IL-15 NPs不仅保护了mRNA，还表现出US响应性和CEUS成像能力。当与UTMD联用时，DPPA/IL-15 NPs实现了PD-L1最佳靶向，促进IL-15 mRNA的递送，并在体外和体内显示出更高的mRNA转染和翻译效率。UTMD可显著增加细胞内ROS，诱导ER应激驱动的ICD，作为启动抗肿瘤免疫的第一步。且UTMD与DPPA/IL-15 NPs组合可增加免疫效应细胞的募集及免疫刺激细胞因子的产生，从而有效抑制肿瘤生长和肿瘤复发。该联合疗法具有通过增强免疫疗法进行临床转化的潜力，并提供实时超声成像指导。参考文献 [1] Wang X, Li F, Zhang J, Guo L, Shang M, Sun X, Xiao S, Shi D, Meng D, Zhao Y, Jiang C, Li J. A combination of PD-L1-targeted IL-15 mRNA nanotherapy and ultrasound-targeted microbubble destruction for tumor immunotherapy. J Control Release. 2024 Jan 24;367:45-60. doi: 10.1016/j.jconrel.2024.01.039.识别微信二维码，添加生物制品圈小编，符合条件者即可加入生物制品微信群！请注明：姓名+研究方向！版权声明本公众号所有转载文章系出于传递更多信息之目的，且明确注明来源和作者，不希望被转载的媒体或个人可与我们联系(cbplib@163.com)，我们将立即进行删除处理。所有文章仅代表作者观点，不代表本站立场。END

信使RNA免疫疗法临床研究

2024-01-12

·drugs

Persistent Fluorinated Chemicals Tied to Higher Risk for Inflammatory Bowel Disease

FRIDAY, Jan. 12, 2024 -- Perfluoroalkyl and polyfluoroalkyl substance (PFAS) exposure is associated with later occurrence of inflammatory bowel disease (IBD), according to a research letter published online Dec. 26 in Clinical Gastroenterology and Hepatology . Manasi Agrawal, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined the association of PFAS mixture concentrations in prediagnostic serum in patients with adult-onset IBD participating in a pilot study within the preclinical Proteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects study. The analysis included military personnel with Crohn disease (CD), those with ulcerative colitis (UC), and age-, sex-, and race-matched healthy controls (25 in each group). The researchers found that estimated mean concentrations in the study population were 5.19 µg/L for perfluorooctane sulfonic acid, 2.57 µg/L for perfluorooctanoic acid, and 2.32 µg/L for perfluorohexane sulfonate, which were comparable to PFAS levels in the general U.S. population. Within one year of diagnosis, each one-unit increase in decile mixture of fluorinated compounds in serum samples, including the known PFAS, was associated with higher odds of CD and UC (odds ratios, 2.13 and 1.76, respectively). At all four time points up to 10 years prior to diagnosis, these associations persisted for the PFAS mixture for both CD and UC. "Studies in larger cohorts, including analyses of pathways perturbed due to PFAS and the impact of new PFAS on disease outcomes, will be informative toward understanding IBD pathways and developing health policies to minimize exposure to harmful chemical pollutants," the authors write. Abstract/Full Text (subscription or payment may be required) Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

临床结果临床研究

100 项与全氟己烷相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	全氟己烷	V08CX01	DB09531

研发状态

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02424955 (CTgov)	N/A	肝细胞癌	11	3D ultrasound+perflutren lipid microspheres	淵膚壓鹽獵鹹鏇襯願淵(蓋淵襯觸廠範鏇繭繭觸) = 鬱鬱鑰鑰願鬱艱顧夢衊醖網獵鏇觸膚鬱構襯醖 (獵顧醖淵餘願顧築願膚, 憲餘製鹽鬱簾鹹廠艱獵 ~ 築鏇網壓積鹹鹽選壓糧) 更多	-	2023-07-11
NCT00584402 (CTgov)	N/A	肝癌	8	perflutren lipid microspheres	淵膚鬱蓋繭餘網鏇糧獵(壓齋鏇窪簾齋醖襯獵蓋) = 獵網艱積鏇積廠齋願蓋構顧艱齋築餘淵壓構窪 (鹹蓋鏇餘壓鹹蓋膚憲製, 衊廠壓醖窪淵糧夢範鏇 ~ 襯鹽繭糧衊遞築網憲夢) 更多	-	2017-07-11