氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症

疼痛

非在研适应症-

原研机构

New York University School of Medicine

在研机构

New York University School of Medicine

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

19

项与氯乙烷相关的临床试验

NCT06011005 / RecruitingN/AIIT

Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel- a Single-blinded Randomized Controlled Trial.

The goal of this single-blinded randomized controlled trial is to compare pain perception during buccal infiltration using indirect EC spray and topical anesthesia and BC 20% topical gel, among seven to 10-year-old school children who attended Pediatric Dentistry Department at Dubai Dental Hospital (DDH), Mohammed Bin Rashid University (MBRU) in Dubai, the United Arab Emirates (UAE).
The main question[s] it aims to answer are:
• How effective is the indirect application of EC topical spray anesthesia on pain perception during intraoral buccal injection in children in comparsion to BC 20%?
Researchers will compare efficacy of 20% Benzocaine (BC) gel and indirect application of Ethyl Chloride (EC) spray to see if reducing pain perception during local anesthesia infiltration.

开始日期2023-09-01

申办/合作机构

Mohammed Bin Rashid University of Medicine & Health Sciences

NCT05405452 / Recruiting临床4期IIT

Investigation of the Effectiveness of Vibratory Stimulus in Trigger Finger Injections

This study aims to compare the effectiveness of the use of no topical anesthesia, topical coolant, and the use of vibration in the reduction of pain during trigger finger injections. This will be done by randomizing patients who are diagnosed with trigger finger, warrant and choose to continue with a steroid injection into each of the respective anesthetic (or lack thereof) methods described. After conducting this and gathering data on the subjects pain felt, we will compare the analgesia from each of the anesthetic methods.

开始日期2023-08-14

申办/合作机构

University of Arizona

NCT06274905 / CompletedN/A

Topical Anaesthesia in Cutaneous Head and Neck Surgery: a Randomized Controlled Trial

This study aims to assess if EMLA or ethyl chloride spray are effective in reducing the pain associated with local anaesthetic administration in cutaneous surgery of the head and neck compared to a placebo and control group through a randomized control trial study design.

开始日期2023-02-20

申办/合作机构

University Hospital Waterford

100 项与氯乙烷相关的临床结果

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100 项与氯乙烷相关的转化医学

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100 项与氯乙烷相关的专利（医药）

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572

项与氯乙烷相关的文献（医药）

2024-04-01·BJOG: An International Journal of Obstetrics & Gynaecology

Xenobiotic metabolites modify immune responses of the cervicovaginal epithelium: potential mechanisms underlying barrier disruption

Article

作者: Landau, Zachary ; Anton, Lauren ; Loder, Aaron ; Gerson, Kristin D

AbstractObjectiveXenobiotic metabolites are exogenous biochemicals that can adversely impact reproductive health. We previously identified xenobiotics in cervicovaginal fluid during pregnancy in association with short cervix. In other organ systems, xenobiotics can modify epithelial barrier function. We hypothesise that xenobiotics dysregulate epithelial cell and macrophage immune responses as a mechanism to disrupt the cervicovaginal barrier.DesignIn vitro cell culture system.SettingLaboratory within academic institution.SampleVaginal, ectocervical and endocervical epithelial cell lines and primary macrophages.MethodsCells were treated with diethanolamine (2.5 mM), ethyl glucoside (5 mM) or tartrate (2.5 mM) for 24 h.Main outcome measuresCytokines and matrix metalloproteinases were measured in cell supernatants (n = 3 per condition). One‐way analysis of variance (ANOVA) with Dunnett's test for multiple comparisons was performed.ResultsDiethanolamine induces inflammatory cytokines, whereas ethyl glucoside and tartrate generally exert anti‐inflammatory effects across all cells. Diethanolamine increases interleukin 6 (IL‐6), IL‐8, interferon γ‐induced protein 10 kDa (IP‐10), growth‐regulated oncogene (GRO), fractalkine, matrix metalloproteinase 1 (MMP‐1), MMP‐9 and MMP‐10 (p < 0.05 for all), factors involved in acute inflammation and recruitment of monocytes, neutrophils and lymphocytes. Ethyl glucoside and tartrate decrease multiple cytokines, including RANTES and MCP‐1 (p < 0.05 for all), which serve as chemotactic factors. Vaginal cells exhibit heightened inflammatory tone compared with cervical cells and macrophages, with a greater number of differentially expressed analytes after xenobiotic exposure.ConclusionsXenobiotic metabolites present in the cervicovaginal space during pregnancy modify immune responses, unveiling potential pathways through which environmental exposures may contribute to the pathogenesis of cervical remodelling preceding preterm birth. Future work identifying xenobiotic sources and routes of exposure offers the potential to modify environmental risks to improve pregnancy outcomes.

2024-02-01·EFSA Journal

Safety of a feed additive consisting of ethyl cellulose for all animal species (International Cellulosics Association)

Article

作者: Ramos, Fernando ; Puente, Secundino López ; Vettori, Maria Vittoria ; Anguita, Montserrat ; López-Alonso, Marta ; Mayo, Baltasar ; Manini, Paola ; Bampidis, Vasileios ; Marcon, Francesca ; Christensen, Henrik ; Azimonti, Giovanna ; Innocenti, Matteo ; Galobart, Jaume ; Pechová, Alena ; Kouba, Maryline ; Woutersen, Ruud ; Dusemund, Birgit ; Petkova, Mariana ; Villa, Roberto Edoardo ; Durjava, Mojca ; Bastos, Maria de Lourdes

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety of ethyl cellulose as a technological feed additive for all animal species. In its previous opinions on the safety and efficacy of the product, the FEEDAP Panel could not conclude on proper identification and characterisation as required for a feed additive. The occurrence of potential toxic impurities could also not be assessed. Based on the new data provided, the feed additive ethyl cellulose was properly identified and characterised and was shown to meet the specifications set for the food additive. Therefore, the conclusions of the safety assessment reached in the previous opinions for ethyl cellulose meeting the food additive specifications, apply to the ethyl cellulose under assessment as a feed additive. The feed additive is considered safe for all animal species, the consumer and the environment. In the absence of data, the FEEDAP Panel is not in the position to conclude on the safety for the user.

2024-01-01·Chemical Biology & Drug Design

Ethyl gallate concurrent administration protects against acetaminophen‐induced acute liver injury in mice: An in vivo and in silico approach

Article

作者: Karthick, Munusamy ; Shree Harini, Karthik ; Ezhilarasan, Devaraj ; Selvaraj, Chandrabose

AbstractAcetaminophen (APAP) in high doses causes acute liver injury and acute liver failure. Ethyl gallate (EG) is a natural polyphenol, possessing antioxidant, anti‐inflammatory, and anti‐microbial properties. Therefore, in this study, we evaluated the protective role of EG against APAP‐induced acute liver injury in mice. Acute liver injury was induced by a single dose of APAP (400 mg/kg., i.p.). In separate groups, EG (10 mg/kg), EG (20 mg/kg), and N‐acetylcysteine (NAC; 1200 mg/kg., i.p.) were administered concurrently with APAP. The mice were sacrificed after 24 h of treatment. Liver marker enzymes of hepatotoxicity, antioxidant markers, inflammatory markers, and histopathological studies were done. APAP administration caused a significant elevation of marker enzymes of hepatotoxicity and lipid peroxidation. APAP administration also decreased enzymic and nonenzymic antioxidants. Acute APAP intoxication induced nuclear factor κ B, tumor necrosis factor‐α, interleukin‐1, p65, and p52 and downregulated IκB gene expressions. Our histopathological studies have confirmed the presence of centrilobular necrosis, 24 h after APAP intoxication. All the above abnormalities were significantly inhibited in groups of mice that were concurrently administered with APAP + EG and APAP + NAC. Our in silico analysis further confirms that hydroxyl groups of EG interact with the above inflammatory proteins at the 3,4,5‐trihydroxybenzoic acid region. These effects of EG against APAP‐induced acute liver injury could be attributed to its antioxidative, free radical scavenging, and anti‐inflammatory potentials. Therefore, this study suggests that EG can be an efficient therapeutic approach to protect the liver from APAP intoxication.

100 项与氯乙烷相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床1期	-	New York University School of Medicine	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	窪衊網鏇積願憲鹹獵糧(艱壓願艱觸鑰廠範遞鬱) = 鏇鏇蓋蓋艱壓獵淵鑰膚夢膚選鏇餘顧衊觸積鏇 (糧艱鑰齋齋艱範簾餘鹹, 壓鑰醖廠製鏇鬱獵積鹹 ~ 繭夢繭廠廠觸淵廠範廠) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	窪衊網鏇積願憲鹹獵糧(艱壓願艱觸鑰廠範遞鬱) = 鏇鏇製積獵網糧鬱鏇餘夢膚選鏇餘顧衊觸積鏇 (糧艱鑰齋齋艱範簾餘鹹, 積簾鹽夢構糧窪夢齋夢 ~ 鏇鹹鬱艱糧積構窪願網) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	餘衊遞觸廠餘鏇觸衊餘(膚構淵廠獵遞壓顧構網) = 窪積網淵選選糧鹹齋糧窪餘獵簾顧窪願鏇觸積 (壓壓積鏇襯顧鬱積醖鑰, 觸願窪網廠夢製衊簾製 ~ 鹹淵鏇鬱觸遞鏇鑰襯夢) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	餘衊遞觸廠餘鏇觸衊餘(膚構淵廠獵遞壓顧構網) = 廠廠廠襯繭餘壓襯衊鑰窪餘獵簾顧窪願鏇觸積 (壓壓積鏇襯顧鬱積醖鑰, 夢顧選遞簾醖鬱窪構襯 ~ 鹽蓋窪蓋選鏇衊蓋衊艱) 更多
NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	窪餘願繭艱淵壓鏇構願(餘鏇窪夢壓糧廠襯遞積) = 艱獵鑰廠襯鏇襯窪鹹鑰壓壓襯淵蓋糧獵網廠淵 (糧壓積鬱壓簾廠築夢繭, 廠簾範襯簾夢鑰襯網壓 ~ 鬱簾憲齋鹹鑰製鑰顧範) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	窪餘願繭艱淵壓鏇構願(餘鏇窪夢壓糧廠襯遞積) = 夢觸糧獵鹽選衊窪醖夢壓壓襯淵蓋糧獵網廠淵 (糧壓積鬱壓簾廠築夢繭, 窪淵窪鏇築獵壓餘夢夢 ~ 窪鹹製蓋鑰鹽蓋鹽襯積) 更多
NCT04207710 (CTgov)	临床4期	疼痛	72	Gebauer's Ethyl Chloride (Microbial Growth on Wrist After Application of Gebauer's Ethyl Chloride)	積夢網夢鬱繭觸壓顧餘(積製蓋齋壓膚夢鏇遞簾) = 齋觸製獵衊願齋積鹽齋齋餘艱願製鬱餘醖窪醖 (鏇選築淵衊衊淵糧觸齋, 鏇積壓製壓構夢淵膚鏇 ~ 醖衊窪壓憲獵鏇獵鑰鹽) 更多	-	2024-03-04
				Gebauer's Ethyl Chloride (Microbial Growth on Lower Back After Application of Gebauer's Ethyl Chloride)	積夢網夢鬱繭觸壓顧餘(積製蓋齋壓膚夢鏇遞簾) = 鑰範選網遞鏇夢鏇遞襯齋餘艱願製鬱餘醖窪醖 (鏇選築淵衊衊淵糧觸齋, 蓋築積選範築憲壓鹹鏇 ~ 觸選範糧網構憲觸網願) 更多