氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症

疼痛

非在研适应症-

原研机构

New York University School of Medicine

在研机构

New York University School of Medicine

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

18

项与氯乙烷相关的临床试验

NCT06651788 / Not yet recruitingN/AIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

开始日期2024-11-01

申办/合作机构

The University of Chicago

NCT06596486 / Not yet recruitingN/AIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

开始日期2024-11-01

申办/合作机构

Barts & The London NHS Trust

CTRI/2024/07/070481 / Not yet recruiting临床2/3期IIT

A Randomised Study to Compare the Effectiveness of One Spray versus Two Sprays of Ethyl Chloride of Reducing Venepuncture Induced Pain in Patients requiring IV Cannulation Before Surgery under Anaesthesia at SMS Medical College, Jaipur - Nil

开始日期2024-07-31

申办/合作机构-

100 项与氯乙烷相关的临床结果

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100 项与氯乙烷相关的转化医学

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100 项与氯乙烷相关的专利（医药）

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589

项与氯乙烷相关的文献（医药）

2024-12-01·Biochemical and Biophysical Research Communications

Ethyl gallate ameliorates diabetes-induced Alzheimer's disease-like phenotype in rats via activation of α7 nicotinic receptors and mitigation of oxidative stress

Article

作者: Nagori, Kushagra ; Nakhate, Kartik T. ; Pradhan, Madhulika ; Nakhate, Kartik T

Cognitive decline, an important comorbidity of type 2 diabetes (T2D), is attributed to oxidative stress and impaired cholinergic signaling in the brain. The α7 nicotinic acetylcholine receptor (α7nAChR) is densely distributed in the hippocampus and cortex, and exerts neuroprotective and procognitive actions. Ethyl gallate (EG), a natural phenolic antioxidant compound, showed high in-silico binding affinity towards α7nAChR and brain penetrability. Therefore, the present study aimed to evaluate the involvement of α7nAChR in the potential of EG to ameliorate T2D-induced Alzheimer's disease-like condition. T2D was induced by intraperitoneal (i.p.) injection of streptozotocin (35 mg/kg) in rats on high-fat diet. Diabetic animals were treated with EG (10 and 20 mg/kg, i.p.) for four weeks, and their learning and memory performance was evaluated by the Morris water maze (MWM). Further, the brains were subjected to biochemical analysis of antioxidants like glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), and oxidative stress marker malonaldehyde (MDA). While diabetic rats showed a significant decline in cognitive performance in the MWM, a substantial improvement was noticed following EG treatment. Further, the diabetes-associated reductions in GSH, SOD, and CAT levels, along with increased MDA contents in the brain, were effectively restored by EG. Interestingly, pre-treatment with α7nAChR antagonist methyllycaconitine (1 mg/kg, i.p.) attenuated the effects of EG on behavioral and biochemical parameters. The results suggest that EG may augment cholinergic signaling in the brain via α7nAChR to mitigate oxidative stress, consequently alleviating T2D-associated dementia. Therefore, EG could be a potential candidate for addressing cognitive impairment comorbid with T2D.

2024-12-01·European Journal of Pharmaceutical Sciences

Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir

Article

作者: Martín-Bartolomé, Laura ; Ruiz-Caro, Roberto ; Notario-Pérez, Fernando ; Veiga, María Dolores

Genital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmission. In this work, we evaluated the potential of three polymers with different characteristics (chitosan, xanthan gum and ethyl cellulose) for obtaining acyclovir extended-release vaginal tablets. By combining the polymers, certain useful synergies were observed to modify their mucoadhesive capacity and control drug release. In the swelling studies, it observed that a polyelectrolyte complex with more moderate swelling and sustained gelation was formed between chitosan and xanthan gum exclusively in acidic medium (simulated vaginal fluid). This complex allowed prolonging the mucoadhesion of the tablets in ex vivo studies performed with vaginal mucosa, which would translate into better retention in the vagina after administration. In addition, the combination of chitosan and xanthan gum allowed obtaining a controlled release of acyclovir for 5 days, regardless of the pH of the medium, which would guarantee that drug release continues even in the presence of seminal fluid.

2024-11-01·International Journal of Pharmaceutics

Fabrication of osmotic pump tablets utilizing semisolid extrusion three-dimensional printing technology

Article

作者: Wang, Xiangyu ; Pan, Hao ; Gong, Ye ; Ji, Yang ; Fang, Dongyang ; Chen, Hao

The utilization of three-dimensional (3D) printing technology is prevalent in the fabrication of oral sustained release preparations; however, there is a lack of research on 3D-printed osmotic pump tablets. A 3D-printed core-shell structure bezafibrate osmotic pump tablet was developed based on the characteristics of rapid absorption and short half-life of bezafibrate, utilizing semisolid extrusion (SSE) 3D printing technology. First, the properties of different shell materials were investigated to define the composition of the shell, and ultimately, the optimal formulation was found to be ethyl cellulose:cellulose acetate:polyethylene glycol = 2:1:2. The formulation of the tablet core was defined based on the printing performance and release behavior. The formulation consisted of bezafibrate, lactis anhydrous, sodium bicarbonate, sodium alginate, polyethylene oxide and sodium dodecyl sulfate at a ratio of 400:400:300:80:50:50. The tablet was capable of achieving zero-order release. The physicochemical properties were also characterized. The pharmacokinetic data analysis indicated that there were no statistically significant differences in the pharmacokinetic parameters between the 3D-printed tablets and the reference listed drugs. There was a strong correlation between the in vitro and in vivo results for the 3D-printed tablets. The results showed that SSE printing is a practical approach for manufacturing osmotic pump tablets.

100 项与氯乙烷相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床1期	-	New York University School of Medicine	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	膚夢鏇膚鬱糧淵壓選膚(網鬱簾觸糧願淵築壓獵) = 積蓋膚積醖夢築獵製觸範遞壓遞鹽齋積鏇憲艱 (廠淵範範醖衊構醖衊鹹, 壓築糧簾願顧襯遞繭衊 ~ 齋夢鏇遞獵築選構鑰襯) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	膚夢鏇膚鬱糧淵壓選膚(網鬱簾觸糧願淵築壓獵) = 鹹築觸襯鏇積鏇憲範觸範遞壓遞鹽齋積鏇憲艱 (廠淵範範醖衊構醖衊鹹, 築夢範襯鑰鑰網鹹繭鏇 ~ 繭衊夢餘鹹選壓壓衊願) 更多
NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	齋衊鏇衊襯蓋鑰網鑰夢(製衊觸積窪鬱積鑰鹹憲) = 艱壓鏇選鹽願憲積壓壓憲願鏇餘蓋鹽願遞夢糧 (鏇艱襯壓繭築膚築糧願, 鏇廠鹹淵鬱鬱範鹹選鹽 ~ 憲網選範淵簾鹽壓繭鏇) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	齋衊鏇衊襯蓋鑰網鑰夢(製衊觸積窪鬱積鑰鹹憲) = 窪膚獵網製鹽簾鬱製製憲願鏇餘蓋鹽願遞夢糧 (鏇艱襯壓繭築膚築糧願, 選範夢壓衊齋壓齋膚網 ~ 選憲範鑰顧醖遞廠壓繭) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	築膚願範遞襯膚膚獵夢(廠夢廠壓醖選襯遞夢衊) = 鑰願觸製鬱夢鹽齋壓積齋網鑰艱壓夢網廠膚襯 (構餘遞鑰鹽遞齋齋築範, 積鑰齋襯襯衊艱餘艱鹹 ~ 觸餘簾膚觸齋獵夢願顧) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	築膚願範遞襯膚膚獵夢(廠夢廠壓醖選襯遞夢衊) = 觸願鏇網蓋網顧築積醖齋網鑰艱壓夢網廠膚襯 (構餘遞鑰鹽遞齋齋築範, 網壓艱餘選壓範獵獵壓 ~ 鹽鬱窪衊淵觸觸蓋艱積) 更多