氯乙烷(Ethyl chloride) - 在研适应症：疼痛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ethyl chloride (USP)、chloroethane、monochloroethane

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病其他疾病

在研适应症

疼痛

非在研适应症-

原研机构-

在研机构

Gebauer Co.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS号75-00-3

关联

26

项与氯乙烷相关的临床试验

NCT06920381

/ Not yet recruiting早期临床1期IIT

Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery: A Randomized Clinical Trial

Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1. If not properly managed, needle phobia can persist, affecting a patient's experience during each visit. This effect may compound and lead to avoidance behaviors that can delay necessary treatments 2. This issue is particularly relevant in a Mohs micrographic surgery (MMS) clinic where each patient experiences several painful needle injections before the day is over.
Ethyl chloride is gaining popularity among dermatologists for its routine use in clinical practice due to its anesthetic and antiseptic properties, especially as a pre-injection agent. Research indicates that cryotherapy or pre-cooling the skin before administering a local anesthetic may offer benefits over topical anesthetics, such as enhanced pain relief, quicker onset, and better patient compliance 3,4. However, to our knowledge, no studies have specifically examined the effectiveness of pre-cooling with ethyl chloride prior to Mohs micrographic surgery. To address this gap, we're conducting a trial aimed at evaluating the impact of pre-cooling with ethyl chloride on pain perception in adult patients undergoing Mohs micrographic surgery with local anesthetic injections.
The trial is a single-center, split-body study. The split-body design will involve dividing the surgical site into two equal halves, with one half (right side relative to patient) designated as the treatment side (receiving ethyl chloride spray prior to lidocaine injection) and the other as the control side (no ethyl chloride spray prior to injection). During the procedure, the participant will be asked to rate the pain associated with the needle injection AND the pain from infiltration of anesthetic from each side of the wound using the visual analog scale (VAS) scoring system (1 = no pain, 10 = most amount of pain possible). The results of the study will help us better understand how to mitigate pain and anxiety for patients requiring MMS.

开始日期2025-06-01

申办/合作机构

University of California, Davis

NCT06651788

/ Not yet recruitingN/AIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

开始日期2025-06-01

申办/合作机构

The University of Chicago

NCT06596486

/ RecruitingN/AIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

开始日期2024-11-01

申办/合作机构

Barts & The London NHS Trust

100 项与氯乙烷相关的临床结果

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100 项与氯乙烷相关的转化医学

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100 项与氯乙烷相关的专利（医药）

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5,287

项与氯乙烷相关的文献（医药）

2025-07-01·Journal of Pharmaceutical and Biomedical Analysis

Effect of Astragalus polysaccharide combined with cisplatin on exhaled volatile organic compounds as biomarkers for lung cancer and its anticancer mechanism

Article

作者: Zhang, Zhijuan ; Zhang, Huanqing ; Shi, Wenmin ; Feng, Weisheng ; Tang, Hanxiao

Cisplatin (DDP) is widely used to fight lung cancer, but there is a risk of immune damage. Astragalus polysaccharides (APS) is the main active component of Astragalus membranaceus Bunge. It has demonstrated anticancer properties across a range of cancer types as well as to be effective against cisplatin induced immune damage. However, its therapeutic mechanism has not been fully explored. This study aimed to explore the antitumor mechanisms of APS and elucidate the relationship between APS and volatile organic compounds (VOCs) in exhaled breath of Lewis lung cancer (LLC) mice. Gas chromatography-mass spectrometry (GC-MS) was utilized to analyze the exhaled VOCs in LLC mice. A specific group of VOCs was identified as potential biomarkers for monitoring tumor progression. Furthermore, the effects of combined treatment with APS and DDP on the concentration of exhaled VOCs in LLC mice was evaluated. Stoichiometric analysis revealed that the levels of 12 VOCs exhibited substantial recovery following APS treatment. And a high concentration of APS (400 mg/kg), when combined with DDP, exhibited enhanced antitumor efficacy. The metabolic pathways involved in the action of APS include 12 pathways. Our methodology elucidated both the effects and mechanisms of APS on lung cancer, as well as the pharmacological enhancement of cisplatin by APS. These findings facilitate real-time monitoring of lung cancer treatments and contribute to the future development of anticancer therapies.

2025-06-01·Food Chemistry

Antioxidant and chemosensory properties of rice (Oryza sativa L.) bran under different oven-roasting conditions

Article

作者: Yoon, Sojeong ; Moon, Hee Sung ; Park, Hyeonjin ; Yu, Se Young ; Hong, Seong Jun ; Ban, Younglan ; Shin, Eui-Cheol

In this study, the antioxidant and chemosensory properties of rice bran were evaluated under different oven-roasting temperatures (160 °C, 180 °C, and 200 °C) and durations (5 min, 10 min, and 15 min). The γ-oryzanol and total phenolic contents initially increased in raw rice bran but decreased with increasing roasting levels, whereas total flavonoid content initially decreased and then increased. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity exhibited a decreasing trend. Electronic tongue (E-tongue) analysis revealed that sweetness was decreased and bitterness was increased as accelerated roasting times and temperatures. Electronic nose (E-nose) analysis confirmed that the generation of vanillin was identified during roasting, which contributed to a vanilla-like odor. The roasting conditions enhanced γ-oryzanol contents while improving flavor were 200 °C for 5 min, 180 °C for 5 min or 10 min, and 160 °C for 5 min or 10 min. These findings provide fundamental insights into the potential use of rice bran by-products as food ingredients.

2025-06-01·Food Chemistry

Sensomics and chemometrics approaches of differential brewed and roasted coffee (Coffea arabica) from Ethiopia using biomimetic sensory-based machine perception techniques: Effects of caffeine on bitter taste and the generation of volatiles

Article

作者: Yu, Se Young ; Moon, Hee Sung ; Ban, Younglan ; Shin, Eui-Cheol ; Park, Hyeonjin ; Hong, Seong Jun

This study investigated the effects of caffeine in coffee extract (CE) prepared under various roasting and brewing conditions on non-volatile characteristics (antioxidant activity, caffeine contents, chlorogenic acid contents, and taste patterns) and volatile compounds. The representative taste of coffee is bitter taste, and it was mainly influenced by roasting processes compared with the contents of caffeine. Non-volatile compounds were influenced by the bean types (regular and decaffeinated beans) and brewing methods, whereas volatile compounds were mainly affected by the brewing methods and roasting processes. In chemometrics approaches, the correlation between caffeine and bitterness (-0.003) and sourness (0.549) was identified. The correlation between chlorogenic acid and bitterness (0.399) and sourness (0.693) was identified. This study is expected to serve as a basis for understanding changes in bitterness and the generation of volatile compounds according to the contents of caffeine.

100 项与氯乙烷相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
疼痛	美国	Gebauer Co.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04207710 (CTgov)	临床4期	疼痛	72	Ethyl Chloride (Microbial Growth on Wrist After Application of Gebauer's Ethyl Chloride)	糧夢廠範鏇衊糧願網鹽(觸鏇顧願窪積簾築壓鏇) = 艱顧鑰齋觸襯遞鹽夢鑰鏇鹽觸衊鏇襯夢鹽衊構 (鑰齋鏇淵顧築製觸選鏇, 鹽繭蓋觸鏇積窪艱鹹範 ~ 築餘蓋願壓鹽憲餘夢夢) 更多	-	2024-03-04
				Ethyl Chloride (Microbial Growth on Lower Back After Application of Gebauer's Ethyl Chloride)	糧夢廠範鏇衊糧願網鹽(觸鏇顧願窪積簾築壓鏇) = 襯鏇獵鑰淵鹹獵製選憲鏇鹽觸衊鏇襯夢鹽衊構 (鑰齋鏇淵顧築製觸選鏇, 淵夢範鑰鹹襯積鬱獵艱 ~ 繭醖醖廠襯網醖獵餘網) 更多
NCT02587143 (CTgov)	N/A	疼痛 \| 麻醉	126	Alcohol (Control)	網糧製淵鹽製構餘淵積(餘鹹範鏇鏇獵網窪構鏇) = 築夢觸餘獵構範夢糧顧衊鬱繭選廠壓顧鏇蓋憲 (廠鏇憲蓋壓衊積遞鹹簾, 選鑰選構簾醖觸鹹選餘 ~ 獵壓齋淵蓋餘選遞觸憲) 更多	-	2020-01-22
				Ethyl chloride (Ethyl Chloride)	網糧製淵鹽製構餘淵積(餘鹹範鏇鏇獵網窪構鏇) = 餘顧糧鹹顧糧艱獵憲壓衊鬱繭選廠壓顧鏇蓋憲 (廠鏇憲蓋壓衊積遞鹹簾, 艱鹽襯獵遞積繭製艱膚 ~ 憲襯鹹製築觸醖顧壓鹽) 更多
NCT03054740 (CTgov)	临床4期	疼痛	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	築蓋襯積淵鹹齋製遞製(鏇糧膚夢構顧獵選遞廠) = 簾網構範網鬱簾襯選糧窪鹽遞醖廠鬱觸窪築鹹 (觸艱齋獵築齋鹽觸簾範, 獵蓋構鹽餘鑰鹹膚壓製 ~ 鑰鏇積憲膚簾餘積餘醖) 更多	-	2018-10-03
				Nature's Tears (Nature's Tears)	築蓋襯積淵鹹齋製遞製(鏇糧膚夢構顧獵選遞廠) = 艱繭糧鹽襯糧夢範淵艱窪鹽遞醖廠鬱觸窪築鹹 (觸艱齋獵築齋鹽觸簾範, 簾選膚膚簾艱鹽鏇網衊 ~ 獵願夢膚願鹹壓遞憲築) 更多
NCT02592629 (CTgov)	临床4期	肩痛	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	選齋壓繭襯鹽糧鹹廠淵(襯積淵糧餘齋窪鹹觸膚) = 夢夢蓋顧淵艱構範鹽醖網鏇範齋選蓋鑰遞製壓 (襯鏇獵築蓋鹹憲餘鏇窪, 窪網夢夢壓膚觸製醖鏇 ~ 顧鏇獵艱製顧衊窪網構) 更多	-	2018-09-10
				lidocaine+Kenalog (Subcutaneous Lidocaine)	選齋壓繭襯鹽糧鹹廠淵(襯積淵糧餘齋窪鹹觸膚) = 廠顧選廠齋襯夢夢積積網鏇範齋選蓋鑰遞製壓 (襯鏇獵築蓋鹹憲餘鏇窪, 願鹽齋憲獵鏇繭鹹願廠 ~ 範顧艱淵網鏇鹽獵淵糧) 更多