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更新于：2025-07-08
Ethyl chloride
氯乙烷
更新于：2025-07-08
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C2H5Cl |
InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N |
CAS号75-00-3 |
关联
26
项与 氯乙烷 相关的临床试验NCT06651788
Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections
NCT06920381
Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery: A Randomized Clinical Trial
NCT06596486
A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia
100 项与 氯乙烷 相关的临床结果
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100 项与 氯乙烷 相关的转化医学
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100 项与 氯乙烷 相关的专利（医药）
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5,309
项与 氯乙烷 相关的文献（医药）2025-08-01Atmospheric Pollution Research
Study on volatile organic compound source profiles and dynamic emission inventories in an integrated refinery-petrochemical complex
作者: Li, Wei ; Li, Sujing ; Cheng, Aizhong
Volatile organic compound (VOCs) emissions from integrated refinery-petrochem. complex (IRPC) were difficult to quantify due to complex production processes and significant fugitive emissions.Previous studies had largely focused on upstream refinery units, with limited research on comprehensive emission factors (EFs) and inventories for the entire IRPC.We analyzed multiple emission sources within IRPC, including equipment leaks (EL), stationary combustion (SC), cooling towers (CT), storage tanks (ST), wastewater collection and treatment systems (WT), process vents (PV), flares (F), and loading operations (LO).The EFs of IRPC was 0.21 kg VOCs/t of crude processed.Addnl., to mitigate the temporal lag associated with traditional emission inventories, we developed dynamic accounting methods for VOCs emissions in IRPC.These methods integrate monitoring data and time-varying meteorol. parameters (e.g., temperature, air pressure, wind speed) to estimate emissions from SC and ST.An integrated anal. system combining gas chromatog.-mass spectrometry (GC-MS) and flame ionization detection (FID) was used to characterize and quantify 115 VOCs species.Composite source profiles were sampling from 35 sites collected across 18 units using a weighted average method.This detailed breakdown provided a more comprehensive view of IRPC emissions compared to studies focusing solely on upstream units.In the IRPC, key pollutants identified include propane, ethane, acetone, ethanol, propylene, and dichloromethane.Alkenes and alkynes had the highest ozone formation potential (OFP) contribution, while aromatics had the greatest secondary organic aerosol formation potential (SOAP) contribution.The study's detailed source profiles and dynamic emission inventory aid petrochem. pollution control and regional air quality improvements.
2025-07-01JOURNAL OF HAZARDOUS MATERIALS
Increased VOC reactivity forcing ozone pollution in the Yangtze River Delta region, China: Evidence from an eight-year observation at an urban site and implications for future control strategies
Article
作者: Chu, Wanghui ; Ma, Qiang ; Chen, Tianshu ; Shi, Xurong ; Wu, Zhijun ; Ning, Miao ; Zhang, Xin ; Zheng, Wei ; Dong, Yuanzhou ; Wu, Yezheng ; Wang, Lijuan
Ozone (O3) is the most critical air pollutant in the Yangtze River Delta (YRD) region of China. This study performed long-term field observation of O3 precursors and meteorological variables from 2015 to 2022 at an urban site in the YRD region, and we identified the driving forces and key sources of O3 formation rate (OFR) and evaluated the future pathways for mitigating O3 pollution, combining the positive matrix factorization and observation-based model (PMF-OBM). During 2015-2022, O3 formation bypassed the NOX titration trap and was in the volatile organic compound (VOC) and NOX transitional regime, and the OFR increased. The changes of rapidly decreased NOX mixing ratio and increased VOC reactivity were the main contributors to the increase in OFR with 69.2 %, while increased temperature, enhanced radiation and other factors contributed to the residual proportion. Our result indicates that simultaneous reductions in ambient VOCs and NOX could significantly mitigate current O3 pollution. The control measurements of O3 pollution should be focused on VOC evaporative emissions (e.g., solvent usage and gasoline evaporation) and complemented by industrial emission and diesel engine exhaust. Furthermore, this study predicted the OFR could decrease around 2025 and that O3 pollution would be under control, and the sustained reductions in pollutant emissions could enable substantial mitigation of O3 pollution under the carbon peak and neutrality policies in China.
2025-07-01JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Effect of Astragalus polysaccharide combined with cisplatin on exhaled volatile organic compounds as biomarkers for lung cancer and its anticancer mechanism
Article
作者: Shi, Wenmin ; Feng, Weisheng ; Zhang, Zhijuan ; Zhang, Huanqing ; Tang, Hanxiao
Cisplatin (DDP) is widely used to fight lung cancer, but there is a risk of immune damage. Astragalus polysaccharides (APS) is the main active component of Astragalus membranaceus Bunge. It has demonstrated anticancer properties across a range of cancer types as well as to be effective against cisplatin induced immune damage. However, its therapeutic mechanism has not been fully explored. This study aimed to explore the antitumor mechanisms of APS and elucidate the relationship between APS and volatile organic compounds (VOCs) in exhaled breath of Lewis lung cancer (LLC) mice. Gas chromatography-mass spectrometry (GC-MS) was utilized to analyze the exhaled VOCs in LLC mice. A specific group of VOCs was identified as potential biomarkers for monitoring tumor progression. Furthermore, the effects of combined treatment with APS and DDP on the concentration of exhaled VOCs in LLC mice was evaluated. Stoichiometric analysis revealed that the levels of 12 VOCs exhibited substantial recovery following APS treatment. And a high concentration of APS (400 mg/kg), when combined with DDP, exhibited enhanced antitumor efficacy. The metabolic pathways involved in the action of APS include 12 pathways. Our methodology elucidated both the effects and mechanisms of APS on lung cancer, as well as the pharmacological enhancement of cisplatin by APS. These findings facilitate real-time monitoring of lung cancer treatments and contribute to the future development of anticancer therapies.
100 项与 氯乙烷 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 疼痛 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 72 | (Microbial Growth on Wrist After Application of Gebauer's Ethyl Chloride) | 壓壓壓膚膚鬱鑰顧襯壓(遞鹹獵鑰築膚衊淵遞繭) = 糧艱襯願鹹鏇鏇網廠廠 鑰襯顧鑰蓋鏇積願觸遞 (鬱鹹蓋顧鏇憲簾鑰膚積, 製鹽齋膚襯顧壓糧膚鏇 ~ 鹹鬱鏇壓觸選簾糧範觸) 更多 | - | 2024-03-04 | ||
(Microbial Growth on Lower Back After Application of Gebauer's Ethyl Chloride) | 壓壓壓膚膚鬱鑰顧襯壓(遞鹹獵鑰築膚衊淵遞繭) = 壓構襯顧鹹壓繭鬱艱醖 鑰襯顧鑰蓋鏇積願觸遞 (鬱鹹蓋顧鏇憲簾鑰膚積, 構獵鏇壓觸夢壓憲鏇獵 ~ 築範齋齋廠獵鬱獵顧廠) 更多 | ||||||
N/A | 126 | Alcohol (Control) | 積鹹鏇願憲鬱廠顧選鏇(襯鏇願選齋蓋糧鹹蓋觸) = 鏇膚築糧鏇窪選鹹糧衊 齋選選蓋糧遞網醖築窪 (餘淵鬱顧襯膚襯齋窪鏇, 鑰壓襯膚顧鏇壓選觸膚 ~ 獵艱鑰壓壓製網夢淵網) 更多 | - | 2020-01-22 | ||
(Ethyl Chloride) | 積鹹鏇願憲鬱廠顧選鏇(襯鏇願選齋蓋糧鹹蓋觸) = 糧餘鹽積鑰製製夢製壓 齋選選蓋糧遞網醖築窪 (餘淵鬱顧襯膚襯齋窪鏇, 範觸醖夢獵廠鑰廠願鏇 ~ 憲糧鏇鹽築鏇顧憲夢簾) 更多 | ||||||
临床4期 | 30 | (Gebauer Ethyl Chloride) | 窪築製積襯夢鹹繭糧醖(選鏇願鑰蓋壓齋醖製製) = 遞獵顧鬱願鏇蓋壓夢範 膚製願製廠糧夢製選餘 (獵壓構憲齋蓋蓋憲範願, 1.302) 更多 | - | 2018-10-03 | ||
Nature's Tears (Nature's Tears) | 窪築製積襯夢鹹繭糧醖(選鏇願鑰蓋壓齋醖製製) = 範積鹽願齋築餘蓋顧膚 膚製願製廠糧夢製選餘 (獵壓構憲齋蓋蓋憲範願, 1.639) 更多 | ||||||
临床4期 | 19 | 獵衊願繭網選鬱鹹鹹鬱(簾醖壓顧窪廠襯蓋鹽齋) = 壓製製選鏇簾觸餘鬱蓋 窪網醖蓋鏇夢範廠簾鏇 (淵鑰窪願餘鹽製獵壓醖, 1.6) 更多 | - | 2018-09-10 | |||
獵衊願繭網選鬱鹹鹹鬱(簾醖壓顧窪廠襯蓋鹽齋) = 築鑰鏇鬱積淵窪壓齋膚 窪網醖蓋鏇夢範廠簾鏇 (淵鑰窪願餘鹽製獵壓醖, 2.19) 更多 |
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