精氨酸谷氨酸(Arginine glutamate) - 在研适应症：高氨血症，肝性脑病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

2-amino-5-(diaminomethylideneamino)pentanoic acid、2-amino-5-guanidino-pentanoic acid、2-aminoglutaric acid

+ [8]

靶点-

作用机制-

治疗领域

其他疾病神经系统疾病消化系统疾病+ [1]

在研适应症

高氨血症肝性脑病

非在研适应症

慢性肝病

原研机构

AY Pharmaceuticals Co Ltd.

在研机构

辅仁药业集团有限公司

AY Pharmaceuticals Co Ltd.

辽宁海思科制药有限公司

非在研机构

扬子江药业集团有限公司

最高研发阶段批准上市

首次获批日期

日本 (1960-11-18),

高氨血症

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C11H23N5O6

InChIKeyRVEWUBJVAHOGKA-WOYAITHZSA-N

CAS号4320-30-3

关联

12

项与精氨酸谷氨酸相关的临床试验

ChiCTR2300068160 / Completed临床4期IIT

The efficacy and safety of arginine glutamate injection in the treatment of hepatic encephalopathy with cirrhosis: a randomized, open, positive-controlled, single-center clinical study

开始日期2020-07-01

申办/合作机构-

CTR20131217 / Completed临床2期

评价精氨酸谷氨酸注射液治疗慢性肝病伴高血氨有效性和安全性的随机、盲法、阳性药平行对照、多中心临床试验

以门冬氨酸鸟氨酸注射液（雅博司）为对照，评价精氨酸谷氨酸注射液治疗慢性肝病伴高血氨的有效性和安全性

开始日期2013-04-12

申办/合作机构

扬子江药业集团有限公司

NCT00213915 / Completed临床4期IIT

Effects of Oral Chronic L-Arginine Supplementation on Exercise and Renal Function of Heart Transplant Recipients

exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction
cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

开始日期2004-02-01

申办/合作机构

Les Hopitaux Universitaires de Strasbourg

100 项与精氨酸谷氨酸相关的临床结果

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100 项与精氨酸谷氨酸相关的转化医学

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100 项与精氨酸谷氨酸相关的专利（医药）

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561

项与精氨酸谷氨酸相关的文献（医药）

2024-05-01·Journal of Plant Research

Involvement of GLR-mediated nitric oxide effects on ROS metabolism in Arabidopsis plants under salt stress

Article

作者: Sekmen Cetinel, Askim Hediye ; Gokce, Azime ; Turkan, Ismail

AbstractPlant glutamate receptor-like channels (GLRs) play important roles in plant development, immune response, defense signaling and Nitric oxide (NO) production. However, their involvement in abiotic stress responses, particularly in regulating Reactive Oxygen Species (ROS), is not well understood. This study aimed to investigate GLR-mediated NO production on ROS regulation in salt-stressed cells. To achieve this, Arabidopsis thaliana Columbia (Col-0) were treated with NaCl, glutamate antagonists [(DNQX (6,7-dinitroquinoxaline-2,3-dione and AP-5(D-2-amino-5-phosphono pentanoic acid)], and NO scavenger [cPTIO (2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt)]. Salt-stressed plants in combination with DNQX and AP-5 have exhibited higher increase in lipid peroxidation (TBARS), hydrogen peroxide (H2O2) and superoxide radical (O−2) contents as compared to solely NaCl-treated plants. Furthermore, NO and total glutathione contents, and S-nitrosoglutathione reductase (GSNOR) activity decreased with these treatments. AP-5 and DNQX increased the activities of NADPH oxidase (NOX), catalase (CAT), peroxidase (POX), cell wall peroxidase (CWPOX) in salt-stressed Arabidopsis leaves. However, their activities (except NOX) were significantly inhibited by cPTIO. Conversely, the combination of NaCl and GLR antagonists, NO scavenger decreased the activities of ascorbate peroxidase (APX), superoxide dismutase (SOD), glutathione reductase (GR), dehydroascorbate reductase (DHAR) and monodehydroascorbate reductase (MDHAR) resulting in elevated GSSG levels, a low GSH/GSSG ratio, impaired ROS scavenging, excessive ROS accumulation and cell membrane damage. The findings of this study provide evidence that GLR-mediated NO plays a crucial role in improvement of the tolerance of Arabidopsis plants to salt-induced oxidative stress. It helps to maintain cellular redox homeostasis by reducing ROS accumulation and increasing the activity of SOD, GSNOR, and the ASC-GSH cycle enzymes.

2024-02-01·Environmental Research

Selective detection of ionic liquid fluorescence probes for visual colorimetry of different metal ions

Article

作者: Liu, Baoyou ; Kang, Kaiming ; Wang, Limin ; Yue, Gang ; Wang, Zhiqiang ; Peng, Zhixiao ; Shi, Lei ; Du, Xiaohan ; Zhang, Xiaojie ; Chen, Shaohua

At present, the fast distinction of different metal ions in pure water media is not only a great challenge, but also drives the protection of water quality in environmental water bodies. In this paper, a novel ionic liquid fluorescent probe Glycolic Acid-L-Arginine (GA-L-Arg) was rationally created and designed through an in-depth study of ionic liquids. It is also used as an innovative multi-ion fluorescent probe for colorimetric detection and separate identification of Fe³⁺ and Co²⁺ in aqueous solutions of various metal ions. GA-L-Arg has excellent water solubility due to the strong hydrophilicity of Glycolic Acid and L-Arginine. The probe showed high sensitivity, extremely significant selectivity, and great pH stability for Fe³⁺ and Co²⁺ in pure water. The GA-L-Arg structure and the mechanism of Fe³⁺ and Co²⁺ detection were analyzed by infrared spectroscopic characterization and quantum chemical calculations. More importantly, the distinct colorimetric partitioning of Fe³⁺ and Co²⁺ was performed by the unique extraction of Fe³⁺ in the presence of the fluorescent probe and buffer solution.

2023-11-01·Pflugers Archiv : European journal of physiology

Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon.

Article

作者: Hashitani, Hikaru ; Nakamori, Hiroyuki

In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D₁-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the bath. Spatio-temporal maps of colonic motility were constructed from video recordings of peristaltic contractions, and the maximum diameter was measured as an index of colonic contractility. GBR (1 μM)-induced dilatations of colonic segments were prevented by SCH (5 μM), L-nitro arginine (L-NA; 100 μM), a nitric oxide synthase inhibitor, or tetrodotoxin (0.6 μM). In contrast, constrictions induced by a higher concentration of SCH (20 μM) were unaffected by either L-NA or tetrodotoxin. The vasoactive intestinal peptide (VIP) receptor antagonist VIP_10-28 (3 μM) or P2Y₁ receptor antagonist MRS 2500 (1 μM) had no effect on either the GBR-induced dilatation or the SCH-induced constriction. In colonic segments that had been pretreated with 6-hydroxydopamine (100 μM, 3 h) to deplete enteric dopamine, GBR failed to increase the colonic diameter, while SCH was still capable of constricting colonic segments. Enteric dopaminergic neurons appear to project to nitrergic neurons to dilate the proximal colon by activating neuronal D₁-like receptors. In addition, constitutively activated D₁-like receptors expressed in cells yet to be determined may provide a tonic inhibition on colonic constrictions.

100 项与精氨酸谷氨酸相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D02397	精氨酸谷氨酸	A05BA01	DB13207

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
高氨血症	日本	AY Pharmaceuticals Co Ltd.	1960-11-18

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肝性脑病	临床1期	中国	辅仁药业集团有限公司	2013-11-13
慢性肝病	药物发现	中国	扬子江药业集团有限公司	2013-04-12
高氨血症	药物发现	中国	扬子江药业集团有限公司	2013-04-12