A Phase 2b, Open-label Study to Evaluate the Efficacy, Safety, Tolerability, Immunogenicity and Treatment Regimens of VTP-300 Combined With Low-dose Nivolumab in Chronic Hepatitis B Infection

This is an open-label study to determine the efficacy, safety, tolerability and immunogenicity of ChAdOx1-HBV and MVA-HBV, together VTP-300, in combination with low-dose nivolumab, in patients with chronic HBV who are virally suppressed with oral anti-viral therapies.

开始日期2022-09-21

申办/合作机构

Vaccitech (UK) Ltd.

ACTRN12622000317796 / Active, not recruiting临床2期

A Phase 2a, Randomized, Blinded, Multicenter Study Investigating a Combination of AB-729 and VTP-300 to evaluate their safety and reactogenicity in Virologically-Suppressed Chronic Hepatitis B Participants.

开始日期2022-06-02

申办/合作机构

Arbutus Biopharma Corp.

[+1]

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项与 ChAdOx1-HBV 相关的文献（医药）

2024-10-01·Hematology, transfusion and cell therapy

Anti-PF4 antibodies and their relationship with COVID infection

Review

作者: Yang, Chieh ; Swankutty, Jibin ; Patel, Rushin ; Wang, Irene ; Chitkara, Akshit ; Kubba, Samir V

Detecting anti-PF4 antibodies remains the golden diagnostic method for heparin-induced thrombocytopenia (HIT) diagnosis with high sensitivity and specificity. Various lab tests detect anti-PF4 antibodies, including immunoassays and functional assays. Even with positive detection of the anti-PF4 antibody, several factors are involved in the result. The concept of anti-PF4 disorders was recently brought to light during the COVID pandemic since the development of vaccine-induced thrombotic thrombocytopenia (VITT) with the adenovirus-vectored-DNA vaccine during the pandemic. Circumstances that detect anti-PF4 antibodies are classified as anti-PF4 disorders, including VITT, autoimmune HIT and spontaneous HIT. Some studies showed a higher percentage of anti-PF4 antibody detection among the population infected by COVID-19 without heparin exposure and some supported the theory that the anti-PF4 antibodies were related to the disease severity. In this review article, we provide a brief review of anti-PF4 disorders and summarize the current studies of anti-PF4 antibodies and COVID-19 infection.

2024-07-01·JOURNAL OF HEPATOLOGY

Phase Ib/IIa randomized study of heterologous ChAdOx1-HBV/MVA-HBV therapeutic vaccination (VTP-300) as monotherapy and combined with low-dose nivolumab in virally-suppressed patients with CHB

Article

作者: Brown, Anthony ; Bussey, Louise ; Anderson, Katie ; O'Brien, Susanne ; Chen, Chi-Yi ; Lo, Gin-Ho ; Barnes, Ellie ; Heo, Jeong ; Evans, Thomas ; Tak, Won Young ; Tseng, Kuo-Chih ; Teoh, Sui Lynn ; Lim, Young-Suk ; Chuang, Wan-Lobg ; Kopycinski, Jakub ; Agarwal, Kaushik ; Tria, A ; Kolenovska, Radka ; Vardeu, Antonella

BACKGROUND & AIMS:

The induction of effective CD8+ T cells is thought to play a critical role in the functional cure of chronic hepatitis B (CHB). Additionally, the use of checkpoint inhibitors is being evaluated to overcome T-cell dysfunction during CHB.

METHODS:

A chimpanzee adenoviral vector (ChAdOx1-HBV) and a Modified vaccinia Ankara boost (MVA-HBV) encoding the inactivated polymerase, core, and S region from a consensus genotype C HBV were studied. Fifty-five patients with virally suppressed CHB and HBsAg <4,000 IU/ml were enrolled. Group 1 received MVA-HBV intramuscularly on Day 0 and 28, Group 2 received ChAdOx1-HBV on Day 0 and MVA-HBV on Day 28 (VTP-300), Group 3 received VTP-300 + low-dose nivolumab (LDN) on Day 28, and Group 4 received VTP-300 plus LDN with both injections.

RESULTS:

VTP-300 alone and in combination with LDN was well tolerated with no treatment-related serious adverse events. Reductions of HBsAg were demonstrated in Group 2: 3 of 18 patients with starting HBsAg <50 IU/ml had durable log₁₀ declines of >0.7 log₁₀ at 2 months after the last dose. Group 3 (n = 18) had mean reductions in HBsAg of 0.76 log₁₀ and 0.80 log₁₀ (p <0.001) at 2 and 7 months after the last dose. Two patients developed persistent non-detectable HBsAg levels. CD4+ and CD8+ antigen-specific T-cell responses were generated and there was a correlation between IFN-γ ELISpot response and HBsAg decline in Group 2.

CONCLUSIONS:

VTP-300 induced CD4+ and CD8+ T cells and lowered HBsAg in a subset of patients with baseline values below 100 IU/ml. The addition of LDN resulted in significant reduction in surface antigen. VTP-300 is a promising immunotherapeutic that warrants further development alone or in combination therapies.

IMPACT AND IMPLICATIONS:

The induction of potent, durable CD8+ T cells may be critical to achieving a functional cure in chronic HBV infection. A prime-boost immunotherapeutic consisting of an adenoviral-vector encoding hepatitis B antigens followed by a pox virus boost was shown to induce CD8+ T cells and to lower HBsAg, either alone or more impactfully when administered in conjunction with a checkpoint inhibitor, in patients with chronic hepatitis B. The use of immunotherapeutics in this setting warrants further evaluation.

CLINTRIALS:

NCT047789.

2023-11-01·JHEP reports : innovation in hepatology

HBV001: Phase I study evaluating the safety and immunogenicity of the therapeutic vaccine ChAdOx1-HBV

Article

作者: Mehta, Reena ; Cargill, Tamsin ; Brown, Anthony ; Cicconi, Paola ; Klenerman, Paul ; Rutkowski, Kathryn ; Chinnakannan, Senthil ; Bussey, Louise ; Barnes, Eleanor ; Holland, Louise ; Sebastian, Sarah ; Sorensen, Henrik ; Evans, Thomas ; Karanth, Benaka ; Ashwin, Emily

Background & Aims:

Millions of people worldwide are infected chronically with HBV, which results in significant morbidity and mortality. Therapeutic vaccination is a strategy that aims to induce functional cure by restoring cellular immunity to HBV. Previously we have shown the candidate HBV immunotherapeutic vaccine ChAdOx1-HBV, encoding all major HBV antigens and a genetic adjuvant (shark invariant chain), is highly immunogenic in mice.

Methods:

Here we report the results of HBV001, a first-in-human, phase I, non-randomised, dose-escalation trial of ChAdOx1-HBV assessed in healthy volunteers and patients with chronic HBV (CHB).

Results:

Vaccination with a single dose of ChAdOx1-HBV was safe and well tolerated in both healthy and CHB cohorts. Vaccination induced high magnitude HBV-specific T cell responses against all major HBV antigens (core, polymerase, and surface) in healthy volunteers. Responses were detected but lower in patients with CHB. T cells generated by vaccination were cross-reactive between HBV C and D genotypes.

Conclusions:

ChAdOx1-HBV is safe and immunogenic in healthy volunteers and patients with CHB. In further studies, ChAdOx1-HBV will be used in combination with other therapeutic strategies with an aim to overcome the attenuated immunogenicity in patients with CHB.

Impact and implications:

Therapeutic vaccine ChAdOx1-HBV, a novel treatment for chronic hepatitis B infection (CHB), has been shown to be immunogenic in preclinical studies. In HBV001, a first-in-human phase I study, we show vaccination with ChAdOx1-HBV is safe and generates high magnitude T cell responses in healthy volunteers and lower levels of responses in patients with CHB. This is an important first step in the development of ChAdOx1-HBV as part of a wider therapeutic strategy to induce hepatitis B functional cure, and is of great interest to patients CHB and clinicians treating the condition.

Clinical Trials Registration:

This study is registered at ClinicalTrials.gov (NCT04297917).

项与 ChAdOx1-HBV 相关的新闻（医药）

2024-10-26

·医药观澜

有望“功能性治愈”乙肝，基因编辑疗法启动1期临床

▎药明康德内容团队编辑 Precision BioSciences近日宣布，其主打在研体内基因编辑疗法PBGENE-HBV的临床试验申请（CTA）已获得摩尔多瓦（Moldova）的监管单位批准。PBGENE-HBV旨在通过消除乙型肝炎病毒（HBV）的共价闭合环状DNA（cccDNA），同时灭活整合在肝细胞中的HBV DNA，以达到功能性治愈慢性乙型肝炎的目的。该公司已启动1期临床项目，并准备进行患者给药。Precision公司预计向全球监管单位提交更多的CTA和IND申请。根据新闻稿，PBGENE-HBV是进入临床阶段的首个靶向HBV的体内基因编辑疗法。据统计，在2019年全球约有3亿人患有慢性乙型肝炎感染。乙肝病毒可造成严重的肝脏感染并造成慢性疾病，约15%至40%的HBV感染患者可能会发展为肝硬化、肝衰竭或肝癌，这些并发症是导致HBV相关死亡的主要原因。乙肝病毒会在患者肝细胞内的细胞核中产生一种独特、游离的cccDNA，这是病毒进行复制时的模板，因此病患cccDNA的含量成为乙肝病患治疗与病情评估的一项重要指标。乙肝病毒DNA还能整合到细胞的DNA中，并成为生成乙肝表面抗原（HBsAg）的源泉之一。目前的肝治疗方式可以限制乙肝病毒的复制，但无法清除这些乙肝病毒的基因成分，这是导致病毒慢性感染与复发的原因，患者通常需要终身用药，这是乙肝治疗时的关键挑战。 PBGENE-HBV是一款基于Precision公司专有ARCUS基因编辑平台所开发的体内基因编辑疗法，设计专门靶向HBV的基因。该疗法通过脂质纳米颗粒将编码ARCUS核酸酶的mRNA递送至肝脏。当在HBV感染的肝细胞中表达时，ARCUS核酸酶可特异性切割乙型肝炎病毒DNA中高度保守的序列，旨在消除cccDNA并灭活整合到细胞DNA中的HBV基因。 ARCUS平台最初由北卡罗来纳州的科学家们于2006年创立公司时开发。与常见的CRISPR/Cas9技术不同，ARCUS使用的是一种源自藻类的编辑酶。根据新闻稿，PBGENE-HBV是首款进入临床阶段的靶向HBV慢性感染根本原因——cccDNA的疗法。 ▲ARCUS基因编辑平台介绍（图片来源：Precision BioSciences公司官网）目前，“功能性治愈”是乙肝治疗的一大重点方向。这指的是虽然我们无法彻底将病毒清除出人体外，但通过治疗，可以将其限制在非常低的水平，低到在血液中都无法被检测出的地步。研究人员们也期望在如此低的水平之下，乙肝患者依靠自身的免疫力就能控制病情，而无需继续接受药物的治疗。除了Precision公司，同样正在开发靶向HBV基因编辑疗法的还有Excision BioTherapeutics。该公司旗下的EBT-107是一种基于CRISPR的双引导RNA（gRNA）基因疗法，旨在有效抑制病毒并消除持续感染的根本来源，该公司计划在2026年第一季度启动临床1b期研究。浩博医药（AusperBio）旗下靶向所有乙肝病毒RNA的反义寡核苷酸（ASO）疗法AHB–137目前正在临床2期试验当中受检视。在临床前研究中，它可以激发所有乙肝病毒RNA的降解，并且显著降低HBsAg水平。Virion Therapeutics也正在开发潜在“first-in-class”检查点修饰免疫疗法VRON-0200，该疗法利用腺病毒载体，在抗原呈递细胞中表达HBV抗原的同时，还表达调节免疫检查点信号通路的重组蛋白，旨在提供慢性HBV感染患者的功能性治愈。今年6月公布该疗法的首个人体临床试验早期数据显示，在至少有28天免疫学随访的9名患者中，大多数患者在接种后显示出增强的T细胞反应。VTP-300则是一种由Vaccitech公司开发、与疫苗作用机制非常类似的免疫疗法。利用Vaccitech的黑猩猩腺病毒载体（ChAdOx1）和改良牛痘安卡拉病毒（MVA）载体表达乙肝病毒抗原，激发抗HBV的免疫应答，有望为慢性乙肝患者带来功能性治愈，目前该疗法正在临床2期试验当中接受评估。参考资料： [1] Precision BioSciences Receives First Approval of Clinical Trial Application to Initiate PBGENE-HBV First-In-Human Study for the Treatment of Chronic Hepatitis B. Retrieved October 24, 2024 from https://investor.precisionbiosciences.com/news-releases/news-release-details/precision-biosciences-receives-first-approval-clinical-trial [2] Exclusive: Moldova clears first gene editing study for HBV in humans. Retrieved October 24, 2024 from https://endpts.com/exclusive-moldova-clears-first-gene-editing-study-for-hbv-in-humans/ [3] Pipeline. Retrieved October 24, 2024 from https://www.excision.bio/technology/pipeline 本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权及其他合作需求，请联系wuxi_media@wuxiapptec.com。免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。

基因疗法临床1期临床申请信使RNA

2024-10-24

·药明康德

首次！旨在功能性治愈乙肝，体内基因编辑疗法步入临床

▎药明康德内容团队编辑 Precision BioSciences今日宣布，其主打在研体内基因编辑疗法PBGENE-HBV的临床试验申请（CTA）已获得摩尔多瓦（Moldova）的监管单位批准。PBGENE-HBV旨在通过消除乙型肝炎病毒（HBV）的共价闭合环状DNA（cccDNA），同时灭活整合在肝细胞中的HBV DNA，以达到功能性治愈慢性乙型肝炎的目的。该公司已启动1期临床项目，并准备进行患者给药。Precision公司预计向全球监管单位提交更多的CTA和IND申请。根据新闻稿，PBGENE-HBV是进入临床阶段的首个靶向HBV的体内基因编辑疗法。据统计，在2019年全球约有3亿人患有慢性乙型肝炎感染。乙肝病毒可造成严重的肝脏感染并造成慢性疾病，约15%至40%的HBV感染患者可能会发展为肝硬化、肝衰竭或肝癌，这些并发症是导致HBV相关死亡的主要原因。乙肝病毒会在患者肝细胞内的细胞核中产生一种独特、游离的cccDNA，这是病毒进行复制时的模板，因此病患cccDNA的含量成为乙肝病患治疗与病情评估的一项重要指标。乙肝病毒DNA还能整合到细胞的DNA中，并成为生成乙肝表面抗原（HBsAg）的源泉之一。目前的肝治疗方式可以限制乙肝病毒的复制，但无法清除这些乙肝病毒的基因成分，这是导致病毒慢性感染与复发的原因，患者通常需要终身用药，这是乙肝治疗时的关键挑战。图片来源：123RF PBGENE-HBV是一款基于Precision公司专有ARCUS基因编辑平台所开发的体内基因编辑疗法，设计专门靶向HBV的基因。该疗法通过脂质纳米颗粒将编码ARCUS核酸酶的mRNA递送至肝脏。当在HBV感染的肝细胞中表达时，ARCUS核酸酶可特异性切割乙型肝炎病毒DNA中高度保守的序列，旨在消除cccDNA并灭活整合到细胞DNA中的HBV基因。ARCUS平台最初由北卡罗来纳州的科学家们于2006年创立公司时开发。与常见的CRISPR/Cas9技术不同，ARCUS使用的是一种源自藻类的编辑酶。根据新闻稿，PBGENE-HBV 是首款进入临床阶段的靶向HBV慢性感染根本原因——cccDNA的疗法。 ▲ARCUS基因编辑平台介绍（图片来源：Precision BioSciences公司官网）目前，“功能性治愈”是乙肝治疗的一大重点方向。这指的是虽然我们无法彻底将病毒清除出人体外，但通过治疗，可以将其限制在非常低的水平，低到在血液中都无法被检测出的地步。研究人员们也期望在如此低的水平之下，乙肝患者依靠自身的免疫力就能控制病情，而无需继续接受药物的治疗。除了Precision公司，同样正在开发靶向HBV基因编辑疗法的还有Excision BioTherapeutics。该公司旗下的EBT-107是一种基于CRISPR的双引导RNA（gRNA）基因疗法，旨在有效抑制病毒并消除持续感染的根本来源，该公司计划在2026年第一季度启动临床1b期研究。浩博医药（AusperBio）旗下靶向所有乙肝病毒RNA的反义寡核苷酸（ASO）疗法AHB–137目前正在临床2期试验当中受检视。在临床前研究中，它可以激发所有乙肝病毒RNA的降解，并且显著降低HBsAg水平。Virion Therapeutics也正在开发潜在“first-in-class”检查点修饰免疫疗法VRON-0200，该疗法利用腺病毒载体，在抗原呈递细胞中表达HBV抗原的同时，还表达调节免疫检查点信号通路的重组蛋白，旨在提供慢性HBV感染患者的功能性治愈。今年6月公布该疗法的首个人体临床试验早期数据显示，在至少有28天免疫学随访的9名患者中，大多数患者在接种后显示出增强的T细胞反应。VTP-300则是一种由Vaccitech公司开发、与疫苗作用机制非常类似的免疫疗法。利用Vaccitech的黑猩猩腺病毒载体（ChAdOx1）和改良牛痘安卡拉病毒（MVA）载体表达乙肝病毒抗原，激发抗HBV的免疫应答，有望为慢性乙肝患者带来功能性治愈，目前该疗法正在临床2期试验当中接受评估。 ▲欲了解更多前沿技术在生物医药产业中的应用，请长按扫描上方二维码，即可访问“药明直播间”，观看相关话题的直播讨论与精彩回放参考资料： [1] Precision BioSciences Receives First Approval of Clinical Trial Application to Initiate PBGENE-HBV First-In-Human Study for the Treatment of Chronic Hepatitis B. Retrieved October 24, 2024 from https://investor.precisionbiosciences.com/news-releases/news-release-details/precision-biosciences-receives-first-approval-clinical-trial [2] Exclusive: Moldova clears first gene editing study for HBV in humans. Retrieved October 24, 2024 from https://endpts.com/exclusive-moldova-clears-first-gene-editing-study-for-hbv-in-humans/ [3] Pipeline. Retrieved October 24, 2024 from https://www.excision.bio/technology/pipeline 免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。分享，点赞，在看，聚焦全球生物医药健康创新

基因疗法临床申请临床1期信使RNA

2024-10-02

·PipelineReview

Barinthus Bio Completes Enrollment for Phase 2b HBV003 Clinical Trial in Chronic Hepatitis B and Phase 1 PCA001 Clinical Trial in Prostate Cancer

OXFORD, UK I October 01, 2024 I Barinthus Biotherapeutics plc (NASDAQ: BRNS), a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates that guide T cells to control disease, announced the completion of enrollment for two clinical trials: HBV003, a Phase 2b clinical trial of VTP-300 in adults with chronic hepatitis B (CHB); and PCA001, a Phase 1 clinical trial of VTP-850 in men with rising prostate-specific antigen (PSA) after definitive local therapy for prostate cancer (i.e., biochemical recurrence). “We continue to execute our strategy and are pleased to complete the enrollment in two different trials in CHB and prostate cancer, two diseases where recruitment can be a real challenge,” said Bill Enright, Chief Executive Officer of Barinthus Bio. “These two fantastic milestones keep us on track for anticipated data readouts from HBV003 in Q4 of 2024 and from PCA001 in the first half of 2025.” The Phase 2b HBV003 trial ( NCT05343481 ) has enrolled 121 participants and is designed to obtain critical dosing information for a potential functional cure regimen for CHB, with participants receiving VTP-300 and low-dose (LD) nivolumab. This trial design builds on positive monotherapy results from the clinical study HBV002, which included an evaluation of VTP-300 given alone and in combination with LD nivolumab. Earlier this year, interim data from the HBV003 trial was presented at the European Association for the Study of the Liver (EASL) Congress and demonstrated that treatment with VTP-300 and LD nivolumab is generally well-tolerated and led to a sustained decline in Hepatitis B surface antigen (HBsAg) levels. Participants reaching Day 169 were assessed for NUC therapy discontinuation eligibility in line with the study criteria, with 76% of participants meeting the criteria (n=16/21). 19% of the eligible participants (n=4/21) reached undetectable levels of HBsAg, with 2 of these patients maintaining undetectable levels for over 16 weeks. The PCA001 Phase 1 trial ( NCT05617040 ) has enrolled 22 participants and is designed to determine the recommended Phase 2 dosing regimen of VTP-850 as well as evaluate safety and efficacy, as measured by PSA and T cell response. VTP-850 is a next-generation prostate cancer immunotherapeutic candidate which utilizes Barinthus Bio’s ChAdOx/MVA platform of two proprietary nonreplicating viral vectors in a sequential dosing approach. About Chronic Hepatitis B Globally it is estimated that there are approximately 254 million people living with CHB infection. This includes up to 2.4 million in the U.S. and 10.6 million in Europe, with the highest prevalence in East Asia and Africa. Approximately 1.1 million people died from hepatitis B virus infection and related complications in 2022, such as liver cirrhosis and hepatocellular carcinoma. Due to low diagnosis rates, only 13% of people living with CHB are aware of their infection and less than 3% had received antiviral treatment at the end of 2022. About Prostate Cancer In 2020, prostate cancer was the fourth most common cancer worldwide, with 1.4 million new cases diagnosed. In the US, out of every 100 American men, an estimated 13 will get prostate cancer during their lifetime. In the UK, prostate cancer is the most common cancer in men, with more than 52,000 people diagnosed with the disease on average each year. 20-30% of patients experience rising levels of PSA after local therapy (e.g. prostatectomy), indicating that disease was not cured by local therapy. Of men who do experience biochemical recurrence, there is a 1 in 9 chance of developing metastases. About Barinthus Bio Barinthus Bio is a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates designed to guide the immune system to overcome chronic infectious diseases and autoimmunity. Helping people living with serious diseases and their families is the guiding principle at the heart of Barinthus Bio. With a focused pipeline built around our proprietary platform technologies, Barinthus Bio is advancing immunotherapeutic product candidates in infectious diseases and autoimmunity, including: VTP-300, that utilizing our ChAdOx/MVA platform designed as a potential component of a functional cure for chronic HBV infection and VTP-1000, utilizing our SNAP-Tolerance Immunotherapy (SNAP-TI) platform and is designed to treat people with celiac disease. Barinthus Bio is also conducting a Phase 1 clinical trial for VTP-850, a second-generation immunotherapeutic candidate designed to treat recurrent prostate cancer. Barinthus Bio’s differentiated technology platforms and therapeutic approach, coupled with deep scientific expertise and focus on clinical development, uniquely positions the company to navigate towards delivering treatments that improve the lives of people with chronic infectious diseases and autoimmunity. For more information, visit www.barinthusbio.com . SOURCE: Barinthus Bio

临床2期免疫疗法临床1期临床结果

100 项与 ChAdOx1-HBV 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
慢性乙型肝炎	临床2期	中国香港	Vaccitech (UK) Ltd.	2022-09-21
慢性乙型肝炎	临床2期	中国台湾	Vaccitech (UK) Ltd.	2022-09-21
慢性乙型肝炎	临床2期	泰国	Vaccitech (UK) Ltd.	2022-09-21
乙型肝炎	临床申请	中国	诺为泰医药科技（上海）有限公司	2022-10-14

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


IM-PROVE (Biospace \| EASL2024) 人工标引	临床2期	慢性乙型肝炎	38	VTP-300	醖願網鹹淵顧艱網餘淵(鬱衊遞遞選遞願繭鬱夢) = 齋構窪鏇餘鏇遞夢積壓繭膚艱醖窪簾獵醖顧築 (鏇衊繭簾鹹衊築齋窪餘 ) 更多	积极	2024-06-06
				Placebo	醖願網鹹淵顧艱網餘淵(鬱衊遞遞選遞願繭鬱夢) = 鑰鬱壓網積鹹夢選鹽鑰繭膚艱醖窪簾獵醖顧築 (鏇衊繭簾鹹衊築齋窪餘 ) 更多
HBV003 (Biospace) 人工标引	临床2期	慢性乙型肝炎	57	VTP-300+nivolumab	鏇衊簾餘廠鬱糧膚遞艱(簾餘窪艱艱網觸構鏇築) = 齋鏇蓋艱艱製窪蓋鑰網淵鑰觸窪憲範簾鹹網齋 (積範構築淵顧鹽築膚觸 ) 更多	积极	2023-11-09
				VTP-300+nivolumab (HBsAg levels ≤200 IU/mL at Day 1)	艱窪蓋廠夢壓醖鑰顧憲(襯窪獵顧醖鏇網範願鏇) = 齋壓齋壓鹽顧製醖構蓋簾遞選鏇醖淵糧範糧廠 (鹽鏇淵選衊蓋糧選顧範 )
AB-729-202 (GlobeNewswire) 人工标引	临床2期	乙型肝炎	40	imdusilan+VTP-300	築憲獵範窪憲顧淵網鬱(範憲壓齋繭衊壓觸繭遞) = There were no serious adverse events, Grade 3 or 4 adverse events or treatment discontinuations. 鹽獵淵憲糧醖鏇範願蓋 (衊憲蓋鹽鏇鏇顧鹹鏇蓋 ) 更多	积极	2023-11-09
				imdusilan+placebo
EASL2022	临床1/2期	-	52	Low dose nivolumab (LDN)	壓醖構艱鏇顧廠鬱艱構(鬱膚製築窪窪齋艱願鹽) = 網鏇膚壓願選蓋範鬱蓋壓範遞顧積鑰製膚膚憲 (製觸壓糧簾鬱襯構簾襯 )	-	2022-06-25