Investigation of the Pharmacokinetics, Safety and Tolerability of Runcaciguat in Participants With Hepatic Impairment (Classified as Child Pugh A or B) and in a Control Group of Age-, Weight-, and Gender-matched Participants Following a Single Oral 15 mg Modified Release (MR) Tablet Dose in a Non-randomized, Non-controlled, Non-blinded, Observational Study With Group Stratification

Researchers are looking for a better way to treat people with chronic kidney diseases. Before a treatment can be approved for patients to take, researchers do clinical studies to better understand its safety and what happens to the drug in the body.
In this study researchers will investigate how the liver function influences blood concentrations of runcaciguat in participants with different degrees of liver impairment compared to participants with normal liver function.
The participants will all take one tablet with 15 mg runcaciguat by mouth. Prior to inclusion into the study, all participants will have a screening examination within 21 to 2 days prior to dosing to check eligibility for study participation.
During the study, all of the participants will stay at the study site for up to 8 days (from Day -1 to Day 7), whereby Day 6 and 7 might also be performed in an ambulatory setting. Blood and urine samples will be collected. The physician will check the participants' heart health using an electrocardiogram (ECG) and by measuring blood pressure and heart rate. The participants will answer questions about their wellbeing and taken medications.
The participants will have a follow-up examination 7 to 11 days after dosing to follow-up their health.
Each participant will be in the study for approximately 5 weeks. The entire study will last about 9 months.

开始日期2021-04-07

申办/合作机构

Bayer AG

NCT04722991

/ Completed临床2期

A Phase 2 Randomized, Placebo-controlled, Double-masked Proof-of-concept Study to Investigate the Efficacy and Safety of Runcaciguat (BAY 1101042) in Patients With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy

This Phase 2 study is conducted to investigate the safety and efficacy of runcaciguat in the treatment of diabetic retinopathy. To assess efficacy, the retinal morphology will be investigated by 7-field color fundus photography for central assessment of the diabetic retinopathy severity score, or DRSS. Two-step DRSS improvement at 24 weeks of treatment will be the primary efficacy endpoint. DRSS assessments are repeated after completion of 48 weeks of treatment. In addition, vision threatening complications will be recorded throughout the study and assessed as secondary efficacy endpoint.

开始日期2021-03-17

申办/合作机构

Bayer AG

CTR20202670

/ Terminated临床1期

在中国健康受试者中评估BAY 1101042单次和多次给药的药代动力学、安全性、耐受性和药效学的I期研究

在中国健康男性受试者中单次和多次给药后，评价BAY 1101042的药代动力学、安全性、耐受性和药效学

开始日期2021-03-17

申办/合作机构

Bayer AG

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100 项与 Runcaciguat 相关的临床结果

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100 项与 Runcaciguat 相关的转化医学

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100 项与 Runcaciguat 相关的专利（医药）

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项与 Runcaciguat 相关的文献（医药）

2025-07-01·CURRENT PHARMACEUTICAL DESIGN

Potential New Treatments for Chronic Kidney Diseases: A Concise Review

Article

作者: Al-Horani, Rami A.

Chronic Kidney Disease (CKD) affects about 37 million Americans. Approximately 20% of patients with high blood pressure and 33% of patients with diabetes have kidney disease. CKD is most common among people aged 65 or older and is slightly more common in women. It substantially impacts certain ethnic groups more than others and is associated with a huge financial burden. End-Stage Kidney Disease (ESKD) is treated with dialysis or a kidney transplantation. CKD and ESKD are very detrimental and expensive illnesses, demanding creative therapeutic interventions to enable better management and enhanced clinical outcomes. Toward this goal, agents from various novel drug classes showed promising safety and efficacy in patients with varying severity of CKD in several phase 2 studies. This concise review will shed light on the clinical trials of runcaciguat, cotadutide, osocimab, and Endothelin Receptor Antagonists (ERAs) in patients with CKD and/or ESKD. These drugs were retrieved following surveying the Clinical Trial database as well as the Pubmed database, both maintained by the US National Library of Medicine.

2025-06-01·EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery of the first isoform-specific sGC activator: Selective activation of GC-1 by runcaciguat

Article

作者: Rühle, Anne ; Sandner, Peter ; Behrends, Sönke ; Stomberg, Svenja ; Wittrien, Theresa

Drug research and development programmes targeting soluble guanylyl cyclase (sGC) have been highly successful, leading to the launch of the sGC stimulators riociguat for pulmonary hypertension (2013) and vericiguat for chronic heart failure (2021). As the main receptor for nitric oxide, sGC plays a vital role in various physiological processes. It consists of an alpha and a beta subunit, with two distinct isoforms identified in humans: GC-1 (α₁/β₁) and GC-2 (α₂/β₁). Growing evidence indicates that these isoforms engage in different downstream signalling pathways, indicating that isoform-specific approaches could lead to novel therapeutic opportunities and reduce potential side effects. In this study, we performed concentration-response measurements with the sGC activators BAY 60-2770, BI 703704 and runcaciguat (BAY 1101042) in cell systems expressing each isoform and in purified enzymes. We found that runcaciguat selectively activated GC-1, while acting as a competitive antagonist to other activators in GC-2, without interfering with nitric oxide. BAY 60-2770 and BI 703704 activated both isoforms, albeit with varying efficacy. Our findings challenge the historical view that the two sGC isoforms are functionally indistinguishable. In fact, we demonstrate that the isoforms can be activated independently, highlighting their distinct functional profiles. Notably, runcaciguat is the first sGC activator identified to selectively target GC-1 at therapeutic concentrations. This selective targeting of isoforms not only opens avenues for new therapeutic strategies but also provides an alternative to knockout animal models for investigating isoform-specific functions.

2025-02-01·BIOCHEMICAL PHARMACOLOGY

Runcaciguat activates soluble guanylyl cyclase via the histidine essential for heme binding and nitric oxide activation

Article

作者: Rühle, Anne ; Elgert, Christin ; Mathar, Ilka ; Behrends, Sönke ; Wittrien, Theresa ; Sandner, Peter

Soluble guanylyl cyclase (sGC) is a well-established pharmacological target for the treatment of acute angina pectoris, pulmonary hypertension and heart failure. Histidine 105 in the heme binding pocket of sGC is a crucial residue for heme binding and natural enzyme activation by NO. It was assumed that the heme-free sGC mutants α₁/β₁H105F and α₁/β₁H105A were valuable research tools for studying NO independent sGC activators. These mutants have been used in drug screening and animal models. We confirm that the first generation of sGC activators cinaciguat and BAY 60-2770 activate the α₁/β₁H105F and α₁/β₁H105A mutants. In contrast, we show that the second generation sGC activators runcaciguat and BAY 543 only activate heme-free sGC when the β₁H105 residue is present. By testing runcaciguat in β₁ H105F knock-in mice, we confirm this histidine-dependency in vivo. We propose a novel classification of sGC activators, distinguishing between the histidine-dependent activators runcaciguat and BAY 543 and the histidine-independent activators cinaciguat, BAY 60-2770 and BI703704. The histidine-dependency of some of the sGC activators provides a compelling rationale for a re-evaluation of previous research and drug development programs based on sGC histidine mutants. Whether the classification of sGC activators based on the activation mechanism also makes a therapeutic difference needs to be clarified in the future.

项与 Runcaciguat 相关的新闻（医药）

2024-09-12

·生物制药小编

拜耳弃子重获新生

近日，知名“变废为宝”的二手商Roivant携带着新公司Pulmovant亮相欧洲呼吸学会大会，新公司Pulmovant手握肺动脉高压药mosliciguat，是从拜耳处收购得来。 Roivant公司的战略一直以来是收购其他人不要的管线，再将其开发，此次交易也不例外，拜耳在2022年上半年放弃了处于I期临床的mosliciguat的开发，而如今Roivant以1400万美元的预付款从拜耳获得了mosliciguat的全球许可权，未来里程碑付款高达2.8亿美元，拜耳还有资格获得专利使用费。 sGC通路的开发历程 Mosliciguat，前称BAY 1237592，是一款吸入剂型可溶性鸟苷酸环化酶（sGC）激动剂，靶向的是一氧化氮（NO）-可溶性鸟苷酸环化酶（sGC）-环鸟苷酸（cGMP）途径。这是1998年诺奖获得者Ferid Murad等三位科学家首次发现的通路，这位美国三院院士的团队最初在研究爆炸物硝化甘油为何能够治疗心脏病。他们意外发现硝化甘油释放的一氧化氮会作为信号分子刺激sGC，进而产生cGMP舒张血管。具体而言，sGC本身是NO的受体，在接收到NO信号后，会发生构象变化，由静息状态转变为高活力激活状态，进而催化GTP生成cGMP。cGMP作为第二信使，能够激活下游的效应蛋白，如PKG（蛋白激酶G），从而调节多种生理过程，如血管舒张、神经信号传递、血小板凝集等。在肺动脉高压和一些心血管疾病中，sGC通路受到抑制，这导致血管紧缩。因此靶向NO/sGC/cGMP途径被广泛认为是治疗心血管疾病，包括慢性心力衰竭、肺动脉高压等疾病的重要靶标。值得一提的是，“伟哥”西地那非同样也是在这一机制背景下开发的药物（“伟哥”西地那非是一种PDE-5抑制剂，PDE-5能够降解cGMP，而抑制PDE-5有利于血管舒张），因此亲自参与“伟哥”临床的Ferid Murad可以说是“伟哥”之父。“伟哥”为代表的PDE-5抑制剂同样也可以用于肺动脉高压。 sGC激动剂药物的困境从药物机制来看，Mosliciguat并不是非常新颖的，毕竟已经有上市药物在先。 mosliciguat的老东家拜耳正是sGC激动剂领域的研发大牛，2013年首款在美上市sGC激动剂Riociguat（利奥西呱）就是由拜耳开发的，Mosliciguat这款后续开发的吸入剂型是拜耳在诸多sGC激动剂中的尝试之一。利奥西呱的劣势主要在于可替代性，是西地那非等PDE-5抑制剂的下位替代，临床实践中常常是患者对西地那非无反应才使用利奥西呱，而且虽然是同一通路的不同机制，但是不能一同使用，否则可能造成严重低血压。考虑到相比之下西地那非价格也不贵，这也难怪，在商业上，利奥西呱并不算太成功，半衰期短，价格贵，又要经常服用，市场起步还晚，市场渗透率自然相对较低，增长也相对比较缓慢。而事实上，后续业内的sGC激动剂迭代产品开发也不顺利。Cyclerion Therapeutics公司想要将praliciguat用于保留射血分数的心衰、糖尿病肾病，但是19年I期临床的概念验证就失败了。开发的另外一款分子Olinciguat在镰状细胞性贫血中的临床也宣告失败，Cyclerion Therapeutics后续打算开发中枢神经系统中的sGC激动剂Zagociguat和CY3018，不过也已经出售给了Tisento Therapeutics公司，Cyclerion Therapeutics现在是待价而沽，寻求股东价值最大化的状态。拜耳方面，vericiguat在2021年以心衰适应症上市，但市场并不看好这一药物的未来市场前景，疗效看起来似乎不如诺华的Entresto和阿斯利康的达格列净，普遍给出的较低销售额预测。 2022年H1拜耳放弃了mosliciguat的开发，其实纵向对比Riociguat，mosliciguat已经将原本12h但半衰期提升到40h了。但横向对比，合作伙伴默沙东的肺动脉高压新药Sotatercept机制完全不相同，服药间隔长，三周一支，虽然价格贵，年治疗费用能达到24.2万美元，但效果好，市场普遍看好Sotatercept未来该是个重磅炸弹。 2024年上半年放弃了runcaciguat用于慢性肾病的开发，转而投入药效和药动更优化的BAY3283142。和上述的开发途径相比，此次Roivant倒是另辟蹊径。 Roivant的算盘拜耳的出售固然有拜耳新CEO上任改革的缩影，Roivant的收购也有自己的算盘。此次Roivant表示观察到Mosliciguat能够使肺动脉高压患者的肺血管阻力（PVR）持续降低高达38%，降幅确实是史无前例的，但值得指出的是，Roivant选择的适应症是与间质性肺病（PH-ILD）相关的肺动脉高压，选择的是存在巨大未满足临床需求中的药物，而他们认为这一患者群体在欧美可能有20万人。如果确实存在这样的一个市场，那么Roivant在这场博弈中可能确实找准了位置，未来默沙东新药Sotatercept可能会取代利奥西呱的位置，实际可能会反映在Sotatercept放量后利奥西呱的销售额变化。 Mosliciguat在这一空白市场的开发，可能为这类sGC激动剂药物找到出路。参考来源： Friebe A, Kraehling JR, Russwurm M, Sandner P, Schmidtko A. The 10th International Conference on cGMP 2022: recent trends in cGMP research and development-meeting report. Naunyn Schmiedebergs Arch Pharmacol. 2023 Aug;396(8):1669-1686. doi: 10.1007/s00210-023-02484-8. Epub 2023 Apr 20. 周婷婷,刘潇.可溶性鸟苷酸环化酶刺激药的研究现状[J].中国临床药理学杂志,2023,39(21):3178-3182.DOI:10.13699/j.cnki.1001-6821.2023.21.029.

并购专利到期

2023-08-08

·FierceBiotech

Bayer ends respiratory distress drug development in latest phase 2 cleanout

It was not until May that Bayer decided “not to pursue further development activities” for adrenomedullin pegol. Bayer has dropped an acute respiratory distress syndrome drug in phase 2 development for “scientific reasons,” the German pharma giant revealed in its latest earnings results. The company “decided not to pursue further development activities” for the drug, called adrenomedullin pegol, in May, Bayer said in this morning’s second-quarter earnings release (PDF). Adrenomedullin is a human hormone that is involved in vasodilation, among other activities. A phase 2 trial of the inhaled formulation wrapped up at the end of last year, according to ClinicalTrials.gov. While Bayer only alluded to “scientific reasons” as the cause of its decision, a note attached to the trials register said the study was terminated due to the results of part A of the trial and “not due to any safety data.” It was not until May that the company decided “not to pursue further development activities” for adrenomedullin pegol, Bayer added. Picking out some other notable pipeline developments over the first half of the year, Bayer used the same document to reaffirm two previously disclosed phase 2 pipeline culls. The company explained that a decision was made in April to halt work on runcaciguat, a soluble guanylate cyclase (sGC) activator that was being developed for chronic kidney disease (CKD). Bayer didn’t give a reason for the decision, but did point out that it hasn’t given up on its sGC program entirely. The company is still pushing ahead with another sGC activator called BAY3283142. The oral therapy, which is currently in a phase 1 trial for CKD, is considered by Bayer to be a “follow-up” therapy to runcaciguat, with the added benefit of an “improved pharmacokinetic/pharmacodynamic profile.” Finally, the company explained that a BDKRB1 receptor antagonist was benched because of the results of a phase 2a trial in neuropathic pain.

临床2期临床3期临床失败临床1期

2023-05-29

·PRNewswire

Diabetic Retinopathy Clinical Trial Pipeline Space Brims With Novel Emerging Therapies with Over 50 Key Companies Working in the Domain | DelveInsight

The prevalence of diabetic retinopathy has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of diabetic retinopathy and the growing research and development activities to develop novel therapies to treat diabetic retinopathy to drive the market. The companies developing the potential therapies in the last stage of development include Roche, Kodiak Sciences, Novartis, and several others. LAS VEGAS, May 29, 2023 /PRNewswire/ -- DelveInsight's ' Diabetic Retinopathy Pipeline Insight – 2023 ' report provides comprehensive global coverage of pipeline diabetic retinopathy therapies in various stages of clinical development, major pharmaceutical companies working to advance the pipeline space and future growth potential of the diabetic retinopathy pipeline domain. Key Takeaways from the Diabetic Retinopathy Pipeline Report DelveInsight's diabetic retinopathy pipeline report depicts a robust space with 50+ active players working to develop 55+ pipeline therapies for diabetic retinopathy treatment. Key diabetic retinopathy companies such as Kodiak Sciences, Novartis, Regenxbio Inc., OcuTerra Therapeutics, Ocular Therapeutix, Bayer, RemeGen, Roche, Ocuphire Pharma, Adverum Biotechnologies, Boehringer Ingelheim, Palatin Technologies, Valo Health, EyePoint Pharmaceuticals, Kubota Vision, MingSight Pharmaceuticals, Oxurion, Aerie Pharmaceuticals, AsclepiX Therapeutics, Ocugen, Ashvattha Therapeutics, Stealth BioTherapeutics, and others are evaluating new diabetic retinopathy drugs to improve the treatment landscape. Promising diabetic retinopathy pipeline therapies in various stages of development include KSI-301, Brolucizumab, RGX 314, OTT-166, OTX-TKI, Runcaciguat, RC 28 E, RG7774, APX3330, ADVM-022, Faricimab, BI 764524, PL8331, OPL-0401, EYP-1901, emixustat hydrochloride, MS-553, THR-149, AR-13503, AXT107, OCU200, D 4517.2, Elamipretide, and others. In May 2023, Oculic Holding AG announced positive top-line results from Stage 1 of its Phase III DIAMOND trial of OCS-01 eye drops in diabetic macular edema (DME). According to the company, the DIAMOND trial in diabetic macular edema with topical OCS-01 met its stage 1 objective of validating the loading and maintenance dosing regimen designed to optimize OCS-01 efficacy potential with robust statistical significance. In April 2023, Palatin Technologies announced The International Journal of Molecular Sciences published a manuscript, "Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the Retina" by Tat Fong Ng and Andrew W. Taylor from Department of Ophthalmology, Boston University Chobanian and Avedisian School of Medicine, in Boston, Massachusetts. The manuscript summarizes data demonstrating the effects of PL8331 in two mouse models of retinal disease, experimental autoimmune uveoretinitis (EAU) and diabetic retinopathy (DR). Palatin and the National Institute of Health (NIH) and the Massachusetts Lions Eye Research Foundation provided funding for the study. In February 2023, Ocugen announced that it had submitted an Investigational New Drug application (IND) with the US Food and Drug Administration (FDA) to initiate a Phase 1 clinical trial of OCU200, a fusion protein with a distinct mechanism of action (MOA), for the treatment of diabetic macular edema (DME). This regulatory milestone fulfills the Company's commitment to file the IND for OCU200 within the first quarter of 2023. In January 2023, Ocuphire Pharma announced topline efficacy and safety results from its ZETA-1 Phase II trial evaluating oral APX3330 for the treatment of diabetic retinopathy (DR). Oral APX3330 demonstrated favorable safety and tolerability allowing for a potential attractive non-invasive option for protection of vision in both eyes in DR patients. In May 2022, EyePoint Pharmaceuticals announced the EYP-1901 license to Betta Pharmaceuticals, to develop and commercialize EYP-1901 in China, Hong Kong, Macau, and Taiwan. EyePoint retains all rights for EYP-1901 in the rest of the world and expands its exclusive rights to local delivery of vorolanib for the treatment of all ophthalmic diseases, including diabetic macular edema (DME). Request a sample and discover the recent advances in diabetic retinopathy drug treatment @ Diabetic Retinopathy Pipeline Report The diabetic retinopathy pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage diabetic retinopathy drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the diabetic retinopathy clinical trial landscape. Diabetic Retinopathy Overview Diabetic retinopathy is a microvascular condition caused by diabetes mellitus's long-term effects. Diabetic retinopathy can cause vision-threatening retinal damage, eventually leading to blindness. It is found in one-third of patients with diabetes and is linked to an increased risk of life-threatening systemic vascular consequences such as stroke, coronary heart disease, and heart failure. Diabetic retinopathy affects an estimated 40% (8% for vision-threatening retinopathy) of people with type 2 diabetes and 86% (42%) of people with type 1 diabetes in the United States. The keys to avoiding diabetic retinopathy blindness are early detection and appropriate intervention. Several large studies have found that the onset of diabetic retinopathy does not usually occur within the first 5 years of type 1 diabetes diagnosis. In contrast, the onset of type 2 diabetes is frequently more subtle, and as a result, retinal damage may be evident at the time of diagnosis. As a result, screening for diabetic retinopathy is advised in type 2 diabetics at the time of diagnosis. Find out more about drugs for diabetic retinopathy @ New Diabetic Retinopathy Drugs A snapshot of the Diabetic Retinopathy Pipeline Drugs mentioned in the report: Learn more about the emerging diabetic retinopathy pipeline therapies @ Diabetic Retinopathy Clinical Trials Diabetic Retinopathy Therapeutics Assessment The diabetic retinopathy pipeline report proffers an integral view of diabetic retinopathy emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Diabetic Retinopathy Pipeline Report Coverage: Global Diabetic Retinopathy Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Diabetic Retinopathy Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Diabetic Retinopathy Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous, Parenteral, Topical Diabetic Retinopathy Therapeutics Assessment By Molecule Type: Recombinant fusion proteins, Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy Diabetic Retinopathy Therapeutics Assessment By Mechanism of Action: Vascular endothelial growth factors inhibitors, Angiogenesis inhibitors, Vascular endothelial growth factor A inhibitors, Gene transference, Integrin alphaVbeta3 antagonists, Integrin alphaVbeta6 inhibitors, Integrin alphavbeta8 inhibitors, Platelet-derived growth factor beta receptor antagonists, Protein tyrosine kinase inhibitors, Proto oncogene protein c-kit inhibitors, Vascular endothelial growth factor receptor 3 antagonists, Vascular endothelial growth factor receptor-1 antagonists, Vascular endothelial growth factor receptor-2 antagonists, Guanylate cyclase stimulants, APEX1 protein inhibitors, DNA apurinic apyrimidinic site lyase inhibitors Key Diabetic Retinopathy Companies: Kodiak Sciences, Novartis, Regenxbio Inc., OcuTerra Therapeutics, Ocular Therapeutix, Bayer, RemeGen, Roche, Ocuphire Pharma, Adverum Biotechnologies, Boehringer Ingelheim, Palatin Technologies, Valo Health, EyePoint Pharmaceuticals, Kubota Vision, MingSight Pharmaceuticals, Oxurion, Aerie Pharmaceuticals, AsclepiX Therapeutics, Ocugen, Ashvattha Therapeutics, Stealth BioTherapeutics, and others. Key Diabetic Retinopathy Pipeline Therapies: KSI-301, Brolucizumab, RGX 314, OTT-166, OTX-TKI, Runcaciguat, RC 28 E, RG7774, APX3330, ADVM-022, Faricimab, BI 764524, PL8331, OPL-0401, EYP-1901, emixustat hydrochloride, MS-553, THR-149, AR-13503, AXT107, OCU200, D 4517.2, Elamipretide, and others. Dive deep into rich insights for new drugs for diabetic retinopathy treatment; visit @ Diabetic Retinopathy Medications Table of Contents For further information on the diabetic retinopathy pipeline therapeutics, reach out @ Diabetic Retinopathy Drug Treatment Related Reports Diabetic Retinopathy Market Diabetic Retinopathy Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key diabetic retinopathy companies, including Genentech, Inc., Regeneron Pharmaceuticals, Roche, Opthea Limited, Regenxbio, Kodiak Sciences Inc, Ocuphire Pharma, Eisai Co Ltd, Apexian Pharmaceuticals, Oculis, among others. Diabetic Retinopathy Epidemiology Forecast Diabetic Retinopathy Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and diabetic retinopathy epidemiology trends. Proliferative Diabetic Retinopathy Pipeline Proliferative Diabetic Retinopathy Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key proliferative diabetic retinopathy companies, including Kubota Vision, among others. Diabetic Neuropathy Pipeline Diabetic Neuropathy Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key diabetic neuropathy companies, including Goldfinch Bio, Novartis, Serodus, CURACLE, Daiichi Sankyo, NeuroBo Pharmaceuticals, Dong-A Pharmaceutical, among others. Diabetic Neuropathy Market Diabetic Neuropathy Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key diabetic neuropathy companies, including Goldfinch Bio, Novartis, Serodus, CURACLE, Daiichi Sankyo, NeuroBo Pharmaceuticals, Dong-A Pharmaceutical, among others. Related Healthcare Services Healthcare Consulting Healthcare Competitive Intelligence Services Healthcare Asset Prioritization Services About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Connect with us on LinkedIn |Facebook|Twitter Contact Us Shruti Thakur [email protected] +1(919)321-6187 Logo: SOURCE DelveInsight Business Research, LLP

临床结果临床1期临床3期

100 项与 Runcaciguat 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
非增殖性糖尿病视网膜病变	临床2期	美国	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	保加利亚	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	捷克	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	丹麦	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	德国	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	拉脱维亚	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	荷兰	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	波兰	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	葡萄牙	Bayer AG	2021-03-17
非增殖性糖尿病视网膜病变	临床2期	罗马尼亚	Bayer AG	2021-03-17

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04722991 (NEON-NPDR, CTgov)	临床2期	非增殖性糖尿病视网膜病变	109	Placebo (Placebo)	齋觸憲衊簾壓淵鹽遞醖 = 衊製衊衊積艱齋繭艱構鏇繭窪窪鹹淵廠繭獵齋 (蓋衊觸願繭簾築糧繭夢, 獵窪齋顧築糧構範獵鑰 ~ 窪窪觸遞鹹蓋鬱製鹹範) 更多	-	2025-04-08
				Runcaciguat (BAY1101042) (Runcaciguat (BAY1101042))	壓餘鑰蓋獵蓋鏇觸襯顧(願艱製衊糧壓觸糧鏇鏇) = 艱願願餘鑰憲鬱餘廠壓鬱鹹鑰餘製鏇壓願艱淵 (襯鏇蓋獵鹹淵鹹糧簾鏇, 製壓觸觸醖鹽製憲壓顧 ~ 繭範鹽鹽憲鑰淵衊醖壓) 更多
NCT04507061 (Pubmed \| Int J Mol Sci)	临床2期	-	-	Runcaciguat 1 mg/kg/bid	網簾齋構製糧淵鹹遞鬱(醖窪鑰網構淵鏇襯襯選) = 築獵糧繭觸壓餘鑰窪願積觸築襯鹽蓋鏇網艱鹹 (襯襯餘鹹糧鬱鬱選範鹹 ) 更多	-	2023-08-25
				Runcaciguat 3 mg/kg/bid	網簾齋構製糧淵鹹遞鬱(醖窪鑰網構淵鏇襯襯選) = 壓簾壓繭選獵餘窪鏇鏇積觸築襯鹽蓋鏇網艱鹹 (襯襯餘鹹糧鬱鬱選範鹹 ) 更多
ARVO2021	N/A	视网膜疾患	-	Runcaciguat	醖窪衊觸襯製繭製壓壓(鑰壓製夢網壓簾鹹窪構) = 衊憲壓遞觸憲醖夢膚齋鬱獵製憲觸憲鹽選糧積 (鹽憲衊夢艱構醖鹹壓夢 ) 更多	-	2021-06-01
				Vehicle	醖窪衊觸襯製繭製壓壓(鑰壓製夢網壓簾鹹窪構) = 蓋夢鏇醖選齋淵艱淵糧鬱獵製憲觸憲鹽選糧積 (鹽憲衊夢艱構醖鹹壓夢 ) 更多
ARVO2021	N/A	视网膜血管疾病	-	Runcaciguat	淵鹹範膚網範淵糧廠網(鑰鏇鹽築願獵範鹹鹹願) = a trend of increased cpRNFL thickness was detected in rat STZ model 壓艱構蓋艱簾遞糧選廠 (積窪製獵鏇築壓構夢製 ) 更多	-	2021-06-01