活血通络粉针(Huoxue Tongluo Powder Injection) - 在研适应症：脑梗塞_专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

神经系统疾病心血管疾病

在研适应症

脑梗塞

非在研适应症-

原研机构-

在研机构

南京中医药大学

江苏康缘药业股份有限公司

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)临床2期

特殊审评-

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关联

2

项与活血通络粉针相关的临床试验

ITMCTR2024000361 / RecruitingIIT

Huoxue Tongluo acupuncture in the treatment of neovascular age-related macular degeneration: a randomized, open-label trial

开始日期2024-07-15

申办/合作机构

中国中医科学院西苑医院

CTR20132036 / Recruiting临床2期

活血通络治疗脑梗死瘀血阻络证（中风中经络急性期）随机双盲、安慰剂对照、剂量探索、多中心Ⅱ期临床试验

在Ⅰ期临床人体耐受性试验的基础上，通过Ⅱ期临床研究，探索不同剂量活血通络粉针治疗脑梗死—瘀血阻络证（中风中经络-急性期）的有效性，观察活血通络粉针临床应用的安全性，为进一步临床试验研究提供依据。

开始日期2013-06-15

申办/合作机构

江苏康缘药业股份有限公司

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100 项与活血通络粉针相关的临床结果

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100 项与活血通络粉针相关的转化医学

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100 项与活血通络粉针相关的专利（医药）

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34

项与活血通络粉针相关的文献（医药）

2024-09-01·Asian Journal of Surgery

Traditional Chinese medicine reyanbao combined with huoxue powder in treatment of knee osteoarthritis of qi stagnation and blood stasis type

Letter

作者: Liu, Chang ; Yan, Sumin ; Li, Fengping ; Mai, Qingxia

2024-03-14·Journal of Back and Musculoskeletal Rehabilitation

Huoxue Tongluo decoction combined with acupuncture in the treatment of lumbar disc herniation and its effect on JOA and VAS scores

Article

作者: Jin, Kang ; Zhong, Zhinian ; Qin, Fengling ; Nie, Rongrong

BACKGROUND: Lumbar disc herniation (LDH) is a common clinical disease of the skeletal system, and its prevalence has been on a rise. OBJECTIVE: To evaluate the efficacy of Huoxue Tongluo decoction plus acupuncture in the treatment of lumbar disc herniation and its effectiveness in improving the functional recovery of the patients’ affected joints and mitigating their pain. METHODS: In this prospective study, 110 patients with lumbar disc herniation enrolled in our Hospital from June 2019 to June 2021 were collected and randomized to receive either conventional treatment (control group) or Huoxue Tongluo Decoction plus acupuncture (study group). RESULTS: Huoxue Tongluo Decoction plus acupuncture resulted in more rapid mitigation of lower extremity symptoms and lumbar symptoms versus conventional treatment (P< 0.05). Patients receiving traditional Chinese medicine (TCM) showed milder inflammatory responses than those with conventional medication, as evidenced by the lower serum concentrations of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and high-sensitivity C-reactive protein (hs-CRP) (P< 0.05). After treatment, the study group had higher Japanese Orthopedic Association (JOA) scores and lower visual analogue scale (VAS) scores than the control group (P< 0.05), suggesting that the combination of the herbal decoction and acupuncture provided better functional recovery of the affected joints and pain mitigation for the patients. Furthermore, the lower Pittsburgh sleep quality index (PSQI) scores in patients in the study group indicated better sleep quality of patients after TCM intervention than after conventional treatment (P< 0.05). Huoxue Tongluo Decoction plus acupuncture was associated with a significantly higher efficacy (94.55%) versus conventional treatment (80%) (P< 0.05). CONCLUSIONS: Huoxue Tongluo Decoction combined with acupuncture significantly offers a viable treatment alternative for lumbar disc herniation with promising treatment outcomes, mitigates patients’ limb pain, and improves their lumbar function and sleep quality. Further trials are, however, required prior to general application in clinical practice.

2024-01-01·Iranian journal of basic medical sciences

Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.

Article

作者: Wu, Qin ; Liu, Ling ; Wang, Nansu ; Shao, Liang ; Wang, Mingming ; Yan, Yan ; Tan, Yali ; Lei, Lei

ObjectivesTubal factor infertility (TFI) is common female infertility responsible for a large portion of female factor infertility. This study reveals the effect of the quercetin of Huoxuehuayu Tongluo Decoction with azithromycin on the pregnancy rate and inflammation of TFI female rats.Materials and MethodsFemale Sprague Dawley rats were constructed into the TFI model and treated with quercetin, Huoxuehuayu Tongluo Decoction, and combination therapy (quercetin and azithromycin). Pregnancy rate and litter size were measured. Network pharmacology was applied to analyze the interaction between Huoxuehuayu Tongluo Decoction and TFI. The combination of quercetin and IL-6 was analyzed by molecular docking. HE staining and electron microscopy were used to observe the histopathology and ultrastructure of fallopian tube tissues. The TNF-α, IL-1β, IL-6, IL-8, and MPO levels were detected by ELISA. The activation of JAK/STAT, MAPK, and NF-κB p65 pathways was detected by western blot or immunohistochemistry.ResultsQuercetin was the main active component of Huoxuehuayu Tongluo Decoction, and could bind to IL-6 in TFI. Target genes were enriched in the IL-17 signaling pathway, JAK-STAT signaling pathway, inflammatory disease, etc. Under the quercetin and azithromycin combination therapy, both rat pregnancy rates and litter sizes increased significantly. quercetin and azithromycin alleviated the symptoms of hydrosalpinx and inflammatory damage in fallopian tube tissues. The phosphorylation of JAK/STAT and MAPK pathways and NF-κB p65 translocation to the nucleus were significantly inhibited by the quercetin and azithromycin therapy.ConclusionQuercetin and azithromycin combination therapy inhibited inflammation and phosphorylation of JAK/STAT and MAPK pathways to improve TFI inflammation and pregnancy function.

100 项与活血通络粉针相关的药物交易

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