泛影酸钠/泛影葡胺(Diatrizoate Sodium/Meglumin diatrizoate) - 在研适应症：造影剂_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Gastroview、Gastrografin

靶点-

作用机制-

治疗领域

其他疾病

在研适应症

造影剂

非在研适应症-

原研机构

G&E Healthcare Co., Ltd.

在研机构

G&E Healthcare Co., Ltd.Bracco Diagnostics, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (1955-08-02),

造影剂

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C18H26I3N3O9

InChIKeyMIKKOBKEXMRYFQ-WZTVWXICSA-N

CAS号131-49-7

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关联

21

项与泛影酸钠/泛影葡胺相关的临床试验

NCT06182319 / Recruiting临床3期IIT

The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study

Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team.
The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO.
This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.

开始日期2024-01-01

申办/合作机构

University of California, Los Angeles

NCT05726097 / Completed临床3期

Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure

The study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.

开始日期2023-02-01

申办/合作机构

Region Skåne Holding AB

[+2]

ACTRN12620000710921 / RecruitingN/A

A Phase 2 study of efficacy: The validation of Gastrografin measurement in postsurgical samples following low anterior resection when the rectal tube is flushed with Gastrografin

开始日期2020-08-18

申办/合作机构-

100 项与泛影酸钠/泛影葡胺相关的临床结果

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100 项与泛影酸钠/泛影葡胺相关的转化医学

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100 项与泛影酸钠/泛影葡胺相关的专利（医药）

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428

项与泛影酸钠/泛影葡胺相关的文献（医药）

2024-05-01·Journal of Trauma and Acute Care Surgery

Improving outcomes in emergency general surgery: Construct of a collaborative quality initiative

Article

作者: Yang, Amanda Y ; Kramer, Kim A ; Gerhardinger, Laura ; Jakubus, Jill L ; Scott, John W ; Golden, Roy J ; Hemmila, Mark R ; Hoppe, Beckie L ; Mitchell, Eric J ; Napolitano, Lena M ; Neiman, Pooja U ; Lindsey, Hugh J ; Mikhail, Judy N

BACKGROUNDEmergency general surgery conditions are common, costly, and highly morbid. The proportion of excess morbidity due to variation in health systems and processes of care is poorly understood. We constructed a collaborative quality initiative for emergency general surgery to investigate the emergency general surgery care provided and guide process improvements.METHODSWe collected data at 10 hospitals from July 2019 to December 2022. Five cohorts were defined: acute appendicitis, acute gallbladder disease, small bowel obstruction, emergency laparotomy, and overall aggregate. Processes and inpatient outcomes investigated included operative versus nonoperative management, mortality, morbidity (mortality and/or complication), readmissions, and length of stay. Multivariable risk adjustment accounted for variations in demographic, comorbid, anatomic, and disease traits.RESULTSOf the 19,956 emergency general surgery patients, 56.8% were female and 82.8% were White, and the mean (SD) age was 53.3 (20.8) years. After accounting for patient and disease factors, the adjusted aggregate mortality rate was 3.5% (95% confidence interval [CI], 3.2–3.7), morbidity rate was 27.6% (95% CI, 27.0–28.3), and the readmission rate was 15.1% (95% CI, 14.6–15.6). Operative management varied between hospitals from 70.9% to 96.9% for acute appendicitis and 19.8% to 79.4% for small bowel obstruction. Significant differences in outcomes between hospitals were observed with high- and low-outlier performers identified after risk adjustment in the overall cohort for mortality, morbidity, and readmissions. The use of a Gastrografin challenge in patients with a small bowel obstruction ranged from 10.7% to 61.4% of patients. In patients who underwent initial nonoperative management of acute cholecystitis, 51.5% had a cholecystostomy tube placed. The cholecystostomy tube placement rate ranged from 23.5% to 62.1% across hospitals.CONCLUSIONA multihospital emergency general surgery collaborative reveals high morbidity with substantial variability in processes and outcomes among hospitals. A targeted collaborative quality improvement effort can identify outliers in emergency general surgery care and may provide a mechanism to optimize outcomes.LEVEL OF EVIDENCETherapeutic/Care Management; Level III.

2024-04-01·Radiology Case Reports

A late presentation of a left paraduodenal hernia in an elderly patient admitted in emergency: A case report

作者: Iovine, Lorenzo ; Urciuoli, Luigi ; Musto, Lanfranco Aquilino ; Brogna, Barbara

Small bowel internal hernias (IHs), a rare cause of small bowel occlusion (SBO) and small bowel strangulation, while more commonly seen in young adults, can also affect elderly patients and pose a significant diagnostic challenge due to their nonspecific symptoms. In most cases, laparotomy was used to diagnose IHs. However, multidetector computed tomography (MDCT) is usually the best imaging tool to use in the emergency setting for the diagnosis of IHs. An 83-year-old man was admitted to emergency with acute abdominal pain and a coffee-ground vomitus. The abdominal MDCT showed a clustered-like appearance of proximal jejunal loops at the level of the Treitz ligament with the absence of transit of the medium water-soluble iodine oral contrast agent (Gastrografin). Mesenteric edema was also present with initial suffering of the intestinal wall. A left paraduodenal hernia (LPDH) with strangulation was suspected following the radiological report. The emergency laparotomy revealed about 20 cm of proximal jejunal loops herniated through a 3 cm wide hernia orifice (HO) along the Treitz ligament, at the level of Landzert fossa, located in the confluence of the descending mesocolon, posterior to the inferior mesenteric vein (IMV) and confirming the LPDH. The patient was discharged in good condition some days later. IHs do not have sufficient coverage in literature, especially in cases regarding elderly patients, however, they can be a cause of SBO in people older than 80 years of age. Radiologists and surgeons should be aware of the anatomical aspects of the IHs.

2024-01-01·Journal of Surgical Research

Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries

Article

作者: Starr, Nichole ; Zewdu, Ebenezer ; Zemenfes, Daniel ; Desalegn, Migbar ; Tamirat, Daniel ; Harris, Hobart ; Igwebuike, Chinaemere ; Aregawi, Yohanna ; Genetu, Abraham ; Getahun, Bantie ; Tadesse, Mekdim ; Sherefa, Kalid

INTRODUCTIONSmall bowel obstruction (SBO) is one of the most common causes for hospital admission in Ethiopia. The use of water-soluble contrast agents (WSCAs) such as Gastrografin to manage adhesive SBO can predict nonoperative resolution of SBO and reduce decision time to surgery and length of hospital stay. However, nothing is known about practice patterns and Gastrografin use in low-income settings. We sought to characterize current management practices, including use of WSCAs, as well as outcomes for patients with SBO in Addis Ababa, Ethiopia.METHODSWe conducted a mixed-methods study consisting of a survey of surgeons throughout Ethiopia and a retrospective record review at five public, tertiary care-level teaching hospitals in Addis Ababa.RESULTSOf the 76 surgeons who completed the survey, 63% had heard of the use of WSCAs for SBO and only 11% used oral agents for its management. Chart review of 149 patients admitted with SBO showed the most common etiology was adhesion (39.6% of admissions), followed by small bowel volvulus (20.8%). Most patients (83.2%) underwent surgery during their admission. The most common diagnosis in patients who did not require surgery was also adhesion (68.0%), as well as for those who had surgery (33.9%), followed by small bowel volvulus (24.2%).CONCLUSIONSThe etiology of SBO in Ethiopia may be changing, with postoperative adhesions becoming more common than other historically more prevalent causes. Although a Gastrografin protocol as a diagnostic and potentially therapeutic aid for SBO is feasible in this population and setting, challenges can be anticipated, and future studies of protocol implementation and effectiveness are needed to further inform its utility in Ethiopia and other low-income and middle-income countries.

100 项与泛影酸钠/泛影葡胺相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
造影剂	中国	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01515696 (CTgov)	临床4期	胎粪性肠梗阻	96	Gastrografin (Gastrografin)	齋壓憲觸築艱窪獵夢淵(蓋繭醖觸膚願願夢顧艱) = 積醖築衊簾糧遞繭鹹衊選齋觸遞鑰鹽繭顧壓廠 (選膚淵艱醖築願餘壓壓, 齋餘選醖夢遞廠膚鑰壓 ~ 窪艱範衊醖廠繭壓夢鑰) 更多	-	2014-07-18
				sterile water (Sterile Water)	齋壓憲觸築艱窪獵夢淵(蓋繭醖觸膚願願夢顧艱) = 夢鹽製壓齋襯鑰憲窪範選齋觸遞鑰鹽繭顧壓廠 (選膚淵艱醖築願餘壓壓, 廠鹹憲膚襯獵鑰積憲鑰 ~ 鹹夢衊繭膚醖淵製醖鑰) 更多
NCT00601809 (Pubmed \| World J Surg)	临床4期	小肠梗阻	76	Water-soluble contrast medium (gastrografin) (Control group)	觸醖鏇選蓋壓艱膚簾顧(鹹積襯選齋餘範獵夢夢) = 蓋鑰醖鑰獵鹽觸範餘築觸壓鹹顧窪憲廠製襯範 (積衊鏇遞遞夢鹽淵糧鹽 )	积极	2008-10-01
				Water-soluble contrast medium (gastrografin) (Study group)	觸醖鏇選蓋壓艱膚簾顧(鹹積襯選齋餘範獵夢夢) = 糧鹽範膚糧築膚鏇膚夢觸壓鹹顧窪憲廠製襯範 (積衊鏇遞遞夢鹽淵糧鹽 )
NCT01440712 (Pubmed \| World J Surg)	临床4期	术后肠梗阻	-	Gastrografin	獵繭範築醖憲壓蓋簾壓(餘夢夢獵鬱繭鹽壓壓選) = 構廠廠鹽鏇鑰齋網夢鏇觸簾簾積鏇艱觸簾選觸 (壓築夢簾製廠艱選憲網, 6.51 ~ 11.68)	不佳	2016-01-01
				Placebo	獵繭範築醖憲壓蓋簾壓(餘夢夢獵鬱繭鹽壓壓選) = 餘窪壓積積觸鬱襯衊選觸簾簾積鏇艱觸簾選觸 (壓築夢簾製廠艱選憲網, 6.96 ~ 10.29)