泛影酸钠/泛影葡胺(Diatrizoate Sodium/Meglumin diatrizoate) - 在研适应症：造影剂_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Gastroview、Gastrografin

靶点-

作用机制-

治疗领域

其他疾病

在研适应症

造影剂

非在研适应症-

原研机构

G&E Healthcare Co., Ltd.

在研机构

G&E Healthcare Co., Ltd.Bracco Diagnostics, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (1955-08-02),

造影剂

最高研发阶段(中国)-

特殊审评-

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结构

分子式C18H26I3N3O9

InChIKeyMIKKOBKEXMRYFQ-WZTVWXICSA-N

CAS号131-49-7

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关联

19

项与泛影酸钠/泛影葡胺相关的临床试验

NCT06182319 / Recruiting临床3期IIT

The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study

Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team.
The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO.
This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.

开始日期2024-01-01

申办/合作机构

University of California, Los Angeles

NCT05726097 / Completed临床3期

Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure

The study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.

开始日期2023-02-01

申办/合作机构

Region Skåne Holding AB

[+2]

ACTRN12620000710921 / RecruitingN/AIIT

A Phase 2 study of efficacy: The validation of Gastrografin measurement in postsurgical samples following low anterior resection when the rectal tube is flushed with Gastrografin

开始日期2020-08-18

申办/合作机构-

100 项与泛影酸钠/泛影葡胺相关的临床结果

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100 项与泛影酸钠/泛影葡胺相关的转化医学

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100 项与泛影酸钠/泛影葡胺相关的专利（医药）

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429

项与泛影酸钠/泛影葡胺相关的文献（医药）

2024-04-01·Radiology Case Reports

A late presentation of a left paraduodenal hernia in an elderly patient admitted in emergency: A case report

作者: Iovine, Lorenzo ; Urciuoli, Luigi ; Musto, Lanfranco Aquilino ; Brogna, Barbara

Small bowel internal hernias (IHs), a rare cause of small bowel occlusion (SBO) and small bowel strangulation, while more commonly seen in young adults, can also affect elderly patients and pose a significant diagnostic challenge due to their nonspecific symptoms. In most cases, laparotomy was used to diagnose IHs. However, multidetector computed tomography (MDCT) is usually the best imaging tool to use in the emergency setting for the diagnosis of IHs. An 83-year-old man was admitted to emergency with acute abdominal pain and a coffee-ground vomitus. The abdominal MDCT showed a clustered-like appearance of proximal jejunal loops at the level of the Treitz ligament with the absence of transit of the medium water-soluble iodine oral contrast agent (Gastrografin). Mesenteric edema was also present with initial suffering of the intestinal wall. A left paraduodenal hernia (LPDH) with strangulation was suspected following the radiological report. The emergency laparotomy revealed about 20 cm of proximal jejunal loops herniated through a 3 cm wide hernia orifice (HO) along the Treitz ligament, at the level of Landzert fossa, located in the confluence of the descending mesocolon, posterior to the inferior mesenteric vein (IMV) and confirming the LPDH. The patient was discharged in good condition some days later. IHs do not have sufficient coverage in literature, especially in cases regarding elderly patients, however, they can be a cause of SBO in people older than 80 years of age. Radiologists and surgeons should be aware of the anatomical aspects of the IHs.

2024-01-01·Internal Medicine

Successful Gastrografin Vermifugation for <i>Taenia saginata</i>-associated Appendicitis

Article

作者: Umekawa, Yasuhiro ; Kobayashi, Keigo

In Japan, public health improvements have lessened parasitic infections, but increased global travel has introduced new disease risks. We report the case a Japanese man who had previously resided in Vietnam, who experienced appendicitis and the presence of segments in his stool. Gastrografin led to the expulsion of Taenia saginata, as confirmed by scolex identification. Remarkably, the appendicitis symptoms subsided after deworming. This case underscores the importance of considering cestode infections in the differential diagnosis of appendicitis, particularly for patients with relevant travel histories, and highlights the evolving challenges in global health and the significance of acquiring detailed patient histories.

2024-01-01·Journal of Surgical Research

Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries

Article

作者: Starr, Nichole ; Zewdu, Ebenezer ; Zemenfes, Daniel ; Desalegn, Migbar ; Tamirat, Daniel ; Harris, Hobart ; Igwebuike, Chinaemere ; Aregawi, Yohanna ; Genetu, Abraham ; Getahun, Bantie ; Tadesse, Mekdim ; Sherefa, Kalid

INTRODUCTIONSmall bowel obstruction (SBO) is one of the most common causes for hospital admission in Ethiopia. The use of water-soluble contrast agents (WSCAs) such as Gastrografin to manage adhesive SBO can predict nonoperative resolution of SBO and reduce decision time to surgery and length of hospital stay. However, nothing is known about practice patterns and Gastrografin use in low-income settings. We sought to characterize current management practices, including use of WSCAs, as well as outcomes for patients with SBO in Addis Ababa, Ethiopia.METHODSWe conducted a mixed-methods study consisting of a survey of surgeons throughout Ethiopia and a retrospective record review at five public, tertiary care-level teaching hospitals in Addis Ababa.RESULTSOf the 76 surgeons who completed the survey, 63% had heard of the use of WSCAs for SBO and only 11% used oral agents for its management. Chart review of 149 patients admitted with SBO showed the most common etiology was adhesion (39.6% of admissions), followed by small bowel volvulus (20.8%). Most patients (83.2%) underwent surgery during their admission. The most common diagnosis in patients who did not require surgery was also adhesion (68.0%), as well as for those who had surgery (33.9%), followed by small bowel volvulus (24.2%).CONCLUSIONSThe etiology of SBO in Ethiopia may be changing, with postoperative adhesions becoming more common than other historically more prevalent causes. Although a Gastrografin protocol as a diagnostic and potentially therapeutic aid for SBO is feasible in this population and setting, challenges can be anticipated, and future studies of protocol implementation and effectiveness are needed to further inform its utility in Ethiopia and other low-income and middle-income countries.

100 项与泛影酸钠/泛影葡胺相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
造影剂	美国	Bracco Diagnostics, Inc.	1955-08-02

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01440712 (Pubmed \| World J Surg)	临床4期	术后肠梗阻	-	Gastrografin	壓製鑰顧窪遞壓鬱壓廠(襯壓獵觸選構膚窪選壓) = 築膚網遞淵衊醖願獵網築簾糧構簾鬱鑰鹽壓遞 (願鹹積鑰鑰簾網餘壓鏇, 6.51 ~ 11.68)	不佳	2016-01-01
				Placebo	壓製鑰顧窪遞壓鬱壓廠(襯壓獵觸選構膚窪選壓) = 蓋糧齋襯膚艱遞醖顧製築簾糧構簾鬱鑰鹽壓遞 (願鹹積鑰鑰簾網餘壓鏇, 6.96 ~ 10.29)
NCT01515696 (CTgov)	临床4期	胎粪性肠梗阻	96	Gastrografin (Gastrografin)	範鹹遞網膚膚築遞鑰顧(遞範廠簾膚壓願艱醖膚) = 觸鏇窪鹽鹽醖鑰鹹壓觸廠觸顧餘鹽觸壓構窪獵 (艱憲壓築範獵積餘蓋鏇, 窪淵鬱襯築鹹壓鑰襯壓 ~ 蓋選淵築膚網鹹願襯淵) 更多	-	2014-07-18
				sterile water (Sterile Water)	範鹹遞網膚膚築遞鑰顧(遞範廠簾膚壓願艱醖膚) = 觸廠顧鑰積餘網醖齋鏇廠觸顧餘鹽觸壓構窪獵 (艱憲壓築範獵積餘蓋鏇, 衊醖顧艱糧齋獵淵觸選 ~ 獵願襯築齋壓構獵淵廠) 更多