更新于：2024-11-26
Diatrizoate Sodium/Meglumin diatrizoate
泛影酸钠/泛影葡胺
更新于：2024-11-26
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1955-08-02), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C18H26I3N3O9 |
InChIKeyMIKKOBKEXMRYFQ-WZTVWXICSA-N |
CAS号131-49-7 |
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关联
19
项与 泛影酸钠/泛影葡胺 相关的临床试验The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Phase 2 study of efficacy: The validation of Gastrografin measurement in postsurgical samples following low anterior resection when the rectal tube is flushed with Gastrografin
100 项与 泛影酸钠/泛影葡胺 相关的临床结果
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100 项与 泛影酸钠/泛影葡胺 相关的转化医学
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100 项与 泛影酸钠/泛影葡胺 相关的专利（医药）
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434
项与 泛影酸钠/泛影葡胺 相关的文献（医药）2025-01-01Radiology case reports
Complicated meconium ileus in a male neonate with cystic fibrosis: Case report
Article
作者: Sellouti, Mohamed ; Abilkassem, Rachid ; Agadr, Aomar
In about 10%-15% of instances, meconium ileus (MI) is the first sign of cystic fibrosis (CF). If a newborn exhibits signs of intestinal obstruction and does not pass meconium within a short period of time after birth, MI is suspected. The cystic fibrosis transmembrane conductance regulator gene (CFTR), which is found on chromosome 7q31, is mutated in CF patients. A premature baby, 5 days old, with clinical signs that were typical of MI. These attempts failed in spite of conservative therapies, such as rectal injection of gastrografin. An ileostomy was made and meconium was manually evacuated after an exploratory laparotomy revealed the presence of a typical MI. At ≥1300 µg/L (reference value ≤1000 µg/L), immunoreactive trypsinogen (IRT) levels were increased, which prompted the start of oral pancreatic enzyme replacement treatment. Discharge at 65 days of age included referrals to primary care and a specialized CF clinic. The baby has since shown normal growth and development. This case highlights the rapid onset of CF in a premature infant with complex MI as the initial clinical presentation.
2024-11-09Cureus Journal of Medical Science
Streamlining the Non-operative Management of Adhesive Small Bowel Obstruction: A Closed-Loop Audit Evaluating the Introduction of a Standardised Gastrografin Protocol in a District General Hospital
Article
作者: Farinella, Eriberto ; Thakur, Apoorva ; Rehman, Saif ; Baho, Yousif
Introduction Adhesive small bowel obstruction (ASBO) is a common cause of admissions to general surgery services. Water-soluble contrast (WSC), such as Gastrografin® (GGF), can be utilised in the conservative management of patients with ASBO, with predictive and possible therapeutic value. We audited the non-operative management of ASBO in the general surgery department of East and North Hertfordshire NHS Trust, a district general hospital. Following the introduction of a hospital-wide protocol standardising the use of GGF in patients with ASBO, a re-audit was conducted to assess its impact. Methods A retrospective audit of ASBO patients who received GGF was conducted in two cycles: before and after the implementation of the protocol. Data were collected between February and June 2022 for group 1 (pre-protocol) and between August and November 2023 for group 2 (post-protocol). Results Forty-eight patients were included in the analysis across both groups: 31 in group 1 (pre-protocol) and 17 in group 2 (post-protocol). The success rate of this non-operative trial with GGF increased from 77% (24/31) in group 1 to 88% (15/17) in group 2. The median duration of conservative management was two days in both groups. The median time from CT scan to GGF administration decreased from 24 hours in group 1 to 19 hours 22 minutes in group 2, and the interval between GGF administration and first abdominal radiograph decreased from 9 hours in group 1 to 6 hours 25 minutes in group 2. Conclusion Our closed-loop audit suggests that by streamlining the non-operative management pathway of adhesive small bowel obstruction, our standardised protocol is safe and possibly improves efficiency within a district general hospital setting.
2024-04-01Radiology case reports
A late presentation of a left paraduodenal hernia in an elderly patient admitted in emergency: A case report
作者: Iovine, Lorenzo ; Urciuoli, Luigi ; Brogna, Barbara ; Musto, Lanfranco Aquilino
Small bowel internal hernias (IHs), a rare cause of small bowel occlusion (SBO) and small bowel strangulation, while more commonly seen in young adults, can also affect elderly patients and pose a significant diagnostic challenge due to their nonspecific symptoms. In most cases, laparotomy was used to diagnose IHs. However, multidetector computed tomography (MDCT) is usually the best imaging tool to use in the emergency setting for the diagnosis of IHs. An 83-year-old man was admitted to emergency with acute abdominal pain and a coffee-ground vomitus. The abdominal MDCT showed a clustered-like appearance of proximal jejunal loops at the level of the Treitz ligament with the absence of transit of the medium water-soluble iodine oral contrast agent (Gastrografin). Mesenteric edema was also present with initial suffering of the intestinal wall. A left paraduodenal hernia (LPDH) with strangulation was suspected following the radiological report. The emergency laparotomy revealed about 20 cm of proximal jejunal loops herniated through a 3 cm wide hernia orifice (HO) along the Treitz ligament, at the level of Landzert fossa, located in the confluence of the descending mesocolon, posterior to the inferior mesenteric vein (IMV) and confirming the LPDH. The patient was discharged in good condition some days later. IHs do not have sufficient coverage in literature, especially in cases regarding elderly patients, however, they can be a cause of SBO in people older than 80 years of age. Radiologists and surgeons should be aware of the anatomical aspects of the IHs.
2
项与 泛影酸钠/泛影葡胺 相关的新闻（医药）2023-04-25
一致性评价上市批准医药出海
100 项与 泛影酸钠/泛影葡胺 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 造影剂 | 美国 | 1955-08-02 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | - | 簾襯壓鏇簾淵構鹹獵夢(窪憲觸膚網願壓網繭蓋) = 築願襯觸襯壓選艱製選 鏇製構觸鹹鑰觸構艱窪 (醖齋簾製積膚簾鑰齋顧, 6.51 ~ 11.68) | 不佳 | 2016-01-01 | |||
Placebo | 簾襯壓鏇簾淵構鹹獵夢(窪憲觸膚網願壓網繭蓋) = 醖積選鹹遞積齋窪獵齋 鏇製構觸鹹鑰觸構艱窪 (醖齋簾製積膚簾鑰齋顧, 6.96 ~ 10.29) | ||||||
N/A | - | 觸壓繭範觸窪獵鹹網齋(廠簾餘遞齋鏇顧獵鹹齋) = 製構築顧觸膚衊範製範 鬱壓齋衊鏇範遞膚鏇醖 (鬱構齋鹽願憲網淵膚鹽 ) 更多 | - | 2015-10-01 | |||
N/A | - | - | Gastrografin with magnesium citrate | 艱築鏇壓積憲蓋獵淵製(獵窪齋築獵築壓壓膚艱) = The median GI transit time was 4h 26 min (range 1h 9 min to 10h 11 min) 觸鏇網夢鹽觸鹹鏇選蓋 (齋築構醖鏇網壓齋糧顧 ) 更多 | - | 2015-10-01 | |
临床4期 | 96 | (Gastrografin) | 憲簾鏇網襯鹹鹽製壓選(鹽顧壓膚衊遞醖鏇齋糧) = 窪淵積壓艱構膚顧顧鏇 簾壓願餘範顧製糧鹽鏇 (艱願夢醖衊夢遞憲簾簾, 襯範築鏇鏇膚製構夢鹽 ~ 顧獵鬱壓餘夢觸艱選夢) 更多 | - | 2014-07-18 | ||
sterile water (Sterile Water) | 憲簾鏇網襯鹹鹽製壓選(鹽顧壓膚衊遞醖鏇齋糧) = 網觸構選廠鑰積顧餘願 簾壓願餘範顧製糧鹽鏇 (艱願夢醖衊夢遞憲簾簾, 範齋餘簾選範齋選壓衊 ~ 鑰鏇夢齋製窪醖選積醖) 更多 |
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