This study is a two-arm placebo controlled randomized clinical trial, to assess the effect of a 12-week EGCG intervention on physical frailty compared to placebo in pre-frail older cancer survivors.

开始日期2024-07-01

申办/合作机构

Rochester Christian University

NCT06206759 / Not yet recruitingN/A

Vitamin C Administration and Triglycerides Level in Critical Care Patients: a Retrospective Study

Vitamin C (ascorbic acid) is a water-soluble vitamin with antioxidant properties. Previous studies showed that the administration of vitamin C was associated with decreased triglyceride (TG) levels in ambulatory patients, especially in patients with type 2 diabetes. The decrease in TG level was more significant the younger the patient's age (less than 52.8 years), the longer the administration of vitamin C lasted (over 12 weeks) and the higher the daily dose was (over 1 gram per day) (2). However, we did not find any studies that examined the relationship between administration of vitamin C and lowering of TG level in critical patients in intensive care. High TG levels are often found in these patients, secondary to sepsis, administration of propofol by continuous infusion, administration of TPN, pancreatitis, liver failure and chronic dyslipidemia, diabetes and chronic renal failure. High TG levels in these patients may cause pancreatitis secondary to elevated TG, and we take several actions to lower TG levels in the unit when they exceed 500 mg per dL in order to avoid these complications. The actions taken include starting treatment with fibrates and/or statins, giving high-dose insulin, stopping the propofol drip and changing it to another hypnotic drug (usually midazolam), and giving fat-free TPN instead of fat-containing TPN. There are of course disadvantages to these interventions, such as drug interactions, longer clearance time and higher incidence of delirium when giving midazolam compared to propofol, hypoglycemia when giving a continuous insulin drip in high doses and giving a lower amount of calories to a patient who will receive TPN without lipids.
There are many studies that examined the administration of vitamin C to patients in intensive care, especially patients with sepsis, with varied but inconclusive results. A recently published meta-analysis found a reduction in mortality among critical intensive care patients treated with intravenous vitamin C, especially in the subgroup of critically ill patients with a high risk of in-hospital mortality. The drug was found to be safe for use among patients in intensive care. In these patients in the various studies, vitamin C treatment was given intravenously in different doses, with most patients receiving a dose of 6 grams per day for 3-5 days. In light of a trend about five years ago that showed an improvement in survival among septic patients in intensive care who were treated with intravenous vitamin C as monotherapy, or in combination with steroids and/or intravenous thiamine, also in the intensive care unit at our institution (as well as in other hospitals) we started giving this treatment, at the recommended dose of 6 grams per day for 3-5 days. Over time, new studies did not find clear benefits for this treatment, so we gradually stopped giving it. However, if indeed vitamin C can contribute to a significant decrease in TG levels in patients in intensive care, there may be a point in administering it to a group of patients with high TG levels, in order to reduce complications associated with a high TG level and/or treatment to reduce it.

开始日期2024-05-01

申办/合作机构

Meir Medical Center

NCT04756063 / Recruiting临床4期IIT

Parenteral Ascorbic Acid Repletion in TransplantatIon (PARTI): A Randomized, Double-Blinded, Placebo-Controlled Trial

A single-center, randomized, double-blinded placebo-controlled trial is proposed to investigate administration of supraphysiologic doses of ascorbic acid (vitamin C, AA) to patients undergoing liver transplantation. Participants randomized to the intervention group will receive intravenous (IV) AA 1500 mg every 6 hours for 48 hours. Participants randomized to the control group will receive a saline placebo. The primary study outcome will be a change in the Sequential Organ Failure Assessment (SOFA) score from baseline to three days after the first dose of drug (dSOFA3). Secondary outcomes will include total vasopressor dose in norepinephrine equivalents, 30-day and 1-year mortality, and serum AA levels.

开始日期2024-05-01

申办/合作机构

University of Wisconsin-Madison

100 项与维生素C 相关的临床结果

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100 项与维生素C 相关的转化医学

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100 项与维生素C 相关的专利（医药）

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50,189

项与维生素C 相关的文献（医药）

2024-12-01·Renal failure

Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study.

Article

作者: Chunli Wang ; Jili Zhao ; Qiaoqiao Zhou ; Jing Li

INTRODUCTION:

Inflammation and oxidative stress play significant roles in the development of chronic kidney disease (CKD). Given the recognized antioxidant properties of vitamin C, our study aimed to explore the correlation between CKD and serum vitamin C levels.

METHODS:

Data were gathered from the 2017-2018 National Health and Nutrition Examination Survey. Participants below 18 years of age, pregnant individuals, those lacking essential data for CKD diagnosis, or individuals with incomplete serum vitamin C data were excluded. Subgroup and weighted multivariable logistic regression analyses were performed to assess the potential correlation between serum vitamin C and CKD.

RESULTS:

Our study comprised 4969 participants, revealing an overall CKD prevalence of 15.0%. The results indicated that individuals with reduced serum vitamin C levels were more likely to be male, possess lower educational attainment, have a diminished poverty-income ratio, engage in heavy drinking, and be current smokers. Additionally, they exhibited a higher prevalence of obesity and diabetes. Significantly, participants in the third quartile group experienced a 37.0%, 47.0%, and 46.6% decrease in the risk of developing albuminuria, low estimated glomerular filtration rate (eGFR), and CKD, respectively. Subgroup analysis demonstrated that individuals between 65 and 80 years of age showed a statistically reduced risk of developing CKD and low eGFR when their serum vitamin C levels fell in the third and fourth quartile groups.

CONCLUSIONS:

Our findings reveal a correlation between elevated serum vitamin C levels and a decreased risk of developing albuminuria, low eGFR, and CKD. Appropriately increasing serum vitamin C levels may hold promise in protecting renal function, particularly among older individuals.

2024-12-01·Applied microbiology and biotechnology

Integrated omics analysis reveals the alteration of gut microbiota and fecal metabolites in Cervus elaphus kansuensis.

Article

作者: Zhenxiang Zhang ; Changhong Bao ; Zhaonan Li ; Caixia He ; Wenjie Jin ; Changzhong Li ; Yanxia Chen

The gut microbiota is the largest and most complex microecosystem in animals. It is influenced by the host's dietary habits and living environment, and its composition and diversity play irreplaceable roles in animal nutrient metabolism, immunity, and adaptation to the environment. Although the gut microbiota of red deer has been studied, the composition and function of the gut microbiota in Gansu red deer (Cervus elaphus kansuensis), an endemic subspecies of red deer in China, has not been reported. In this study, the composition and diversity of the gut microbiome and fecal metabolomics of C. elaphus kansuensis were identified and compared for the first time by using 16S rDNA sequencing, metagenomic sequencing, and LC-MS/MS. There were significant differences in gut microbiota structure and diversity between wild and farmed C. elaphus kansuensis. The 16S rDNA sequencing results showed that the genus UCRD-005 was dominant in both captive red deer (CRD) and wild red deer (WRD). Metagenomic sequencing showed similar results to those of 16S rDNA sequencing for gut microbiota in CRD and WRD at the phylum and genus levels. 16S rDNA and metagenomics sequencing data suggested that Bacteroides and Bacillus might serve as marker genera for CRD and WRD, respectively. Fecal metabolomics results showed that 520 metabolites with significant differences were detected between CRD and WRD and most differential metabolites were involved in lipid metabolism. The results suggested that large differences in gut microbiota composition and fecal metabolites between CRD and WRD, indicating that different dietary habits and living environments over time have led to the development of stable gut microbiome characteristics for CRD and WRD to meet their respective survival and reproduction needs. KEY POINTS: • Environment and food affected the gut microbiota and fecal metabolites in red deer • Genera Bacteroides and Bacillus may play important roles in CRD and WRD, respectively • Flavonoids and ascorbic acid in fecal metabolites may influence health of red deer.

2024-06-01·IBRO neuroscience reports

The protective role of prenatal administration of ascorbic acid on autistic-like behavior in a rat model of autism

Article

作者: Margedari, Parisa ; Goudarzi, Iran ; Sepehri, Hamid

Background:

Autism is a complicated neurodevelopmental disorder characterized by several behavioral impairments. The pathology of autism is complex and not fully known. Several recent studies have shown alterations in the activities of antioxidant enzymes in autism. Vitamin C is a potent antioxidant that is present in high concentrations in the brain and acts as a neuromodulator. Prefrontal abnormality has been hypothesized to underlie autistic symptoms. The present study investigated the protective effect of prenatally Vitamin C on autistic-like behaviors, oxidative stress status, and histopathological change of prefrontal in valproic acid (VPA) rat model of autism.

Method:

The model of autism was induced by subcutaneous administration of Valproic acid (600 mg/kg) to pregnant rats at gestational day 12.5. Vitamin C was administered 600 mg/L in drinking water from the 5th day of gestaion (GD5) up to postnatal day 23 (PND23). Thirty-two rat offspring were divided into four groups: Control, Vitamin C, VPA, and Vitamin C + VPA. The offspring were tested for repetitive behaviors and cognitive ability with a Y-maze task and social interaction with a play behavior task on 31st of Postnatal days. Glutathione (GSH), superoxide dismutase (SOD) activity, and the histological change in the prefrontal lobe were assessed at the end of the study. The number of neurons from the left prefrontal lobe was counted in duplicate from slides stained with hematoxylin-eosin.

Results:

In the Y-maze apparatus, spontaneous alteration significantly decreased in the prenatal VPA treated rats compared to control rats showing autistic-like behavior; pre and postnatal Vitamin C treatment increased the alternation indicated benefit effect of Vitamin C. Prenatal VPA treatment impaired play behavior such as sniffing, grooming and darting. Vitamin C treatment attenuated the problems in male offspring social behavior. Histological examination showed an increase in the number of cells in the prefrontal cortex of valproic acid offspring rats compared to other groups. Moreover, prenatal VPA decreased antioxidant enzyme activities in the cortex (PFC) attenuated by Vitamin C administration.

Conclusion:

The present study showed that valproic acid induced oxidative stress and neural changes in the prefrontal lobe when administered prenatally which in turn may cause the development of some autistic-like behaviors, and vitamin C may reduce this symptom with its antioxidant effects.

293

项与维生素C 相关的新闻（医药）

2024-04-07

·药研发

抗炎饮食怎么吃？“抗炎食物”和“促炎食物”清单请收好！

“抗炎饮食”的说法正在流行，以往人们较为陌生的“抗炎饮食”“促炎饮食”成了热门词汇。那么，炎症对健康危害有多大？真的有吃了会促进炎症反应的食物吗？真正的抗炎饮食又该怎么吃？慢性炎症对健康危害有多大？这里说的“炎症”和我们平时说的“发炎”并不是一回事，平时说的发炎多为受伤以后的细菌感染导致的；而这里说的“炎症”是指体内的炎症环境，是人体内可能存在的慢性炎症，与人体C-反应蛋白和白介素的变化相关。身体慢性低度炎症，一般不容易察觉到，已有研究发现，其与亚健康、癌症、糖尿病、心脑血管疾病、阿尔茨海默病等都存在一定相关性。①1. 疲劳乏力、亚健康重庆大学附属肿瘤医院老年肿瘤科主任、营养科主任余慧青2023年在医院公众号刊文中表示，如果你平时有疲劳、乏力、状态差、亚健康状况，可能和身体慢性炎症有关。①2. 诱发癌症2023年发布的《抗炎饮食预防肿瘤的专家共识》表示，身体慢性低度炎症状态是诱发肿瘤的机制之一。②持续性的慢性炎症会对身体造成伤害，促进癌症的发生。比如：吸烟-气管炎-肺癌、胃炎-胃癌、慢性溃疡性结肠炎-结肠癌、肝炎-肝癌等。③3. 增加帕金森、心脏病风险特别是对于老年人，炎性衰老过程中的促炎反应还会增加阿尔茨海默病、帕金森病、动脉粥样硬化、心脏病、肌肉衰减等风险。如果本身就已经患有慢性疾病，慢性炎症的影响会更加不利。④“抗炎食物”和“促炎食物”清单请收好！中山大学孙逸仙纪念医院临床营养科林秀红曾在大众健康杂志刊文中表示，日常的生活习惯和饮食模式，都能在某种程度上影响慢性炎症的发展。在均衡营养的基础上，可以多选择具有“抗炎”效应的食物，认识和避免食用“促炎”食物。⑤【多吃丨“抗炎食物”清单】浙江省宁波市第一医院内分泌科主任励丽和营养科营养师刘佳宁曾在大众健康刊文中推荐了10种抗炎食物。⑥1. 三文鱼三文鱼含有抗炎成分欧米伽-3脂肪酸，对预防多种疾病都有帮助。可以每周吃两次鱼类。如果你不喜欢鱼，可以尝试高质量的鱼类相关食品。2. 海带这种含高纤维的褐色藻类可以帮助对抗炎症，而且有抗肿瘤和抗氧化的功效。海带、裙带菜和海藻都是很好的食物。3. 特级初榨橄榄油作为地中海地区的长寿秘诀，这种食用油提供了健康的脂肪量，可以对抗炎症、降低患哮喘和关节炎的风险，还可以保护心脑血管。4. 十字花科蔬菜青花菜、甘蓝小包菜、羽衣甘蓝和花椰菜都含抗氧化剂，可以使机体免受有害化合物的损伤。5. 蓝莓蓝莓不但可以减少炎症，而且可以防止大脑老化，预防癌症以及老年痴呆。6. 姜黄这种香料含一种天然的抗炎化合物——姜黄素，咖喱中也有这种成分。7. 姜姜对健康有很多益处，其中就有对抗炎症和控制血糖的作用。喝姜茶对任何一种饮食都是很好的补充品。8. 大蒜尽管在研究中的表现不稳定，但大蒜的确可以帮助对抗炎症、调节血糖和控制感染。9. 绿茶这种茶类含有抗炎的类黄酮成分，甚至还可以减少患某些癌症的风险。10. 红薯含有丰富的复合碳水化合物、纤维、β-胡萝卜素、锰和维生素B6、维生素C。红薯可以帮助体内的炎症康复。【少吃丨“促炎食物”清单】中国营养学会会员、注册营养师薛庆鑫2022年在科学辟谣刊文中表示，按照膳食炎症指数评分方法来看，以下食物都属于促炎食物。⑦1. 过量红肉红肉，包括常吃的猪牛羊肉，摄入过多的红肉会促进身体炎症反应的发生，还会增加患2型糖尿病、结直肠癌以及肥胖的风险。2. 加工肉类肉类食品在加工生产过程中会产生包括N-亚硝基化合物、多环芳烃类和杂环胺类在内的大量有害物质，过量食用会提高人体的氧化应激水平，产生炎症反应，比如烟熏肉、烤肉、火腿、香肠、培根等。3. 高碳食物摄入过多高碳水化合物的食物会刺激炎症分子的表达，比如精细的主食以及含糖较高的食物。4. 高盐食物食盐摄入过高不仅是高血压的危险因素，还会刺激炎症反应，对靶器官造成损害，比如烹调盐放得过多、常吃盐渍肉、咸菜。5. 反式脂肪酸经常摄入含有反式脂肪酸的食物也会促进炎症的发生，比如含有起酥油的面包、含有植脂末的奶茶、含有代可可脂的巧克力、含有人造奶油的蛋糕等。转自健康时报

2024-04-06

·CPHI制药在线

药品风险管理之二：换一种角度看药品的风险管理计划

关注并星标我们前言质量风险管理是一种事先的、有组织的活动，要求企业基于各种历史数据、理论分析、意见及风险涉众，对所有风险相关过程进行分析和评价，识别出潜在风险；进而进行风险分级，通过风险评估的结果来决定所需采用的适宜控制方法，从而达到质量风险管理的目的。ICH《Q9质量风险管理》更是将其定义为贯穿整个产品生命周期，用于药物（医疗）产品质量风险评估、控制、沟通和评审的系统化过程。除了《药品年度报告管理规定》要求持有人报告药品上市后风险管理计划制定及实施情况外，注册申请阶段同样要求申请人提交风险管理计划，所以，结合整个产品生命周期来制定风险管理计划，将是每个药品生产企业迫切需要掌握的内容。今天我们就换一种思路来聊一聊贯穿于产品整个寿命周期的风险管理计划。相关阅读：《药品风险管理之一：换一种角度看药品的风险管理过程》1 目的根据相关法律法规要求，从产品的设计开发开始开展风险管理评估，评价产品在安全性、有效性和质量可控性等方面存在的风险，并根据风险的高低采取相应的改进预防措施，确保产品的安全、有效、质量可控。2 风险管理方针主动发现风险问题，有效控制风险项目，以前瞻性或回顾式方式全面评估产品质量风险，最大限度的降低产品在寿命周期内的污染、交叉污染以及混淆、差错等风险，确保持续稳定的交付符合预期用途和注册要求的产品，保护患者利益。3 产品概述简略描述产品组成、本计划涉及的型号、工作原理、适用范围、市场情况、临床应用中可能出现的问题。4 范围适用于产品整个生命周期。5 风险管理小组的职责和权限风险管理活动并一定要形成正式的团队，但不管什么类型或级别的风险都应由合适的人员来参与评估。如：总经理：对产品风险负主要责任，保障协调项目所需人力、资金等资源；批准风险管理计划、风险管理报告，负责风险管理的组织、协调实施。质量受权人：风险管理的组织协调及执行监督人员，对风险分析管理的实施负责，并从整个生产周期的角度估计风险。研发经理：编制《风险管理计划》，会同其他组员从各个角度提出可能的风险，评估发生概率并采取措施，并协同销售人员从临床医学角度评估风险。质量负责人：主要从产品质量控制及历史问题的统计分析角度提出可能的风险；评估发生概率并采取措施。生产负责人：从产品生产过程控制和工艺设计的角度提出可能的风险，评估发生概率并采取措施。销售负责人：负责协调组织专家及客户，从临床实际应用的角度提出可能的风险；评估发生概率并采取措施。注册专员：从满足相关法律法规及国家、行业标准的角度提出意见。采购负责人：配合其他部门选择合格供方。6 风险管理计划内容6.1 市场调研阶段由研发部牵头：收集产品市场信息和相关资料，识别产品使用中的风险和产品实现过程中可能会遇到的风险。初步列出《风险因素清单》，确定所有的风险事件并初步估计其结果。6.2 设计开发初期1）由研发部牵头：根据设计开发输入资料及《风险因素清单》，分析风险产生的根本原因，确定影响风险发生的关键因素和可能造成的风险，综合风险管理小组的意见，形成《风险分析记录表》。并对《风险分析记录表》进行评审，评审其正确性和完整性。2）由研发部牵头：根据已识别的风险因素，按照规定的风险可接受准则（详见第7部分），评估风险因素的发生概率和严重程度，明确可接受与不可接受的风险。可接受的风险无需采取控制措施，对合理可降低的风险采取相应的措施予以控制，对不经过收益分析即判定为不可接受的风险，首先判定风险是否可以被降低，降低后的收益是否超过风险本身，然后采取控制措施降低风险。3）由研发部牵头：采取各种措施和方法，消灭或减少风险发生的可能性，将风险降至可接受程度。结合产品特性及风险评估过程中确定的需要降低的风险，形成《风险控制措施表》。并对《风险控制措施表》进行评审，评审其正确性和完整性。6.3 试生产阶段1）由研发部牵头：组织设计开发输出、验证、确认、批量生产等工作，验证风险控制措施的执行。并对风险控制措施的适用性和可操作性进行评审。2）由研发部牵头：按规定的风险可接受准则进行再次评价，必要时，可形成《剩余风险评价表》。3）由研发部、生产部、质量管理部共同牵头：试生产结束，评价风险管理过程的完整性、正确性和充分性（必要时可提供各控制点的合格率、符合性信息）。4）由总经理和研发部经理牵头：形成《风险管理报告》，并对其进行评审6.4 设计更改（若有）由研发部、生产部、质量管理部共同牵头，对拟更改事项进行评估：①设计更改风险的判定；②评估设计更改风险处境的风险；③设计更改的风险评价；④拟定设计更改的风险控制措施计划；⑤更改结束后，验证风险控制措施计划的执行；⑥设计更改后的剩余风险评价；⑦组织拟制完善《风险管理报告》，并组织评审。6.5生产和生产后信息由研发部、生产部、质量管理部共同牵头：按照《风险管理控制程序》进行生产和生产后信息的收集、评价，并形成《年度生产和生产后信息收集、评价汇总表》，对每一项信息及时开展分析评价，不断完善改进风险管理过程。7 风险可接受性准则7.1 严重度的定义7.2 概率的定义7.3 风险可接受准则风险是风险发生的概率及其造成损害严重程度的函数，用H表示风险值，P表示风险发生的概率，S表示风险发生造成的损害严重程度，则风险值可用公式表示：H=f（P，S）。参考单一故障原理，规定风险的可接受范围，将风险分为三个等级，可接受准则见下表：说明：A可接受的风险：不需要采取措施，常规监测即可。R合理可降低的风险：建议采取措施降低风险，并进行重点监测。U不可接受的风险：必须采取措施，降低为合理可行降低的风险或可接受的风险，并采取加严监测。8 验证要求对风险控制措施的实施及其适宜性、充分性和有效性进行验证，验证方法可根据产品特点综合相关标准要求结合经济性、可行性等因素进行评估，选择适当的方式方法，如人为制造超限法、同类产品比较法、样品试制与测试、批量生产与测试等，制定专项验证方案，并保留所有验证相关的文件与记录。9 获得相关生产后信息的一个或多个方法生产和生产后信息决定了是否需要改进产品（尤其是安全性），是上市后风险管理的直接依据。方法可参考以下方式：1）相关方反馈，如对产品和服务的建议、投诉等。2）不良事件、召回等向监管机构报告的相关事项。3）内、外部审核发现的问题及整改情况。4）过程与产品的监视和测量情况。5）纠正和预防措施完成情况。6）可能影响质量管理体系的变更。10 其他需要说明的情况1）风险可接受准则对应不同类别的产品，区别可能很大，如维生素C和抗肿瘤药物，两个产品的风险可接受准则差别必然很大，这里只做提示，风险管理小组应根据具体产品的安全特性具体分析。2）产品上市后，每年管理评审前，应结合市场反馈、生产中的问题进行风险管理，各部门提供相应数据（也可作为管理评审的输入文件），由质量管理部牵头，组织风险管理小组进行新风险和以往识别风险的适宜性评估，适时更新风险管理文档，持续到产品寿命终止。参考文献1《制药行业质量风险管理：实践指南》何国强2《BG公司生物医用材料开发风险管理研究》杨晴雯3《一次性使用输液器产品设计开发风险管理研究》王辉4《医疗器械研发项目风险管理研究》杨西康作者简介：今夏，多年从事医药质量法规和生产现场监督指导工作，指导大量企业成功完成多款产品的注册申报和体系考核，具有扎实的质量法规理论知识和丰富的实战经验。熟悉《GB/T 19001-2016/ISO 9001：2015质量管理体系要求》等QMS系列标准。期间通过了执业药师考试、聘任了中级工程师。【智药研习社近期课程预告】来源：智药公会声明：本文仅代表作者观点，并不代表制药在线立场。本网站内容仅出于传递更多信息之目的。如需转载，请务必注明文章来源和作者。投稿邮箱：Kelly.Xiao@imsinoexpo.com点击阅读原文，进入智药研习社~

医药出海

2024-04-04

·PRNewswire

LA ROCHE-POSAY CELEBRATES NATIONAL VITAMIN C DAY ON APRIL 4TH

La Roche-Posay's 10% Pure Vitamin C Serum is formulated with 10% Vitamin C to leave skin more radiant & hydrated NEW YORK, April 4, 2024 /PRNewswire/ -- For the fourth year in a row, dermatologist-recommended skincare brand La Roche-Posay is celebrating National Vitamin C Day on April 4th. La Roche-Posay aims to raise awareness of the key skin benefits of the ingredient and educate on proper usage of vitamin C products for optimal skin health. Continue Reading La Roche-Posay Vitamin C was one of the most searched for skincare ingredients of 2023, with an average of 8.3k searches per month.1 The powerful ingredient has quickly become a holy grail due to its versatility and suitability for all skin types and tones. Vitamin C has been a go-to ingredient for neutralizing free radicals that can lead to premature signs of aging. Dermatologically known benefits of Vitamin C for skin health include: Visibly boosts skin radiance Provides hydration Helps to reduce redness and even skin tone La Roche-Posay's 10% Pure Vitamin C Serum is formulated with an optimal level of Vitamin C (10%), alongside the exfoliating properties of salicylic acid and soothing effects of neurosensine. Vitamin C is an antioxidant that can help restore radiance, prevent premature aging, even out skin tone, and correct skin texture. 10% Pure Vitamin C Serum can be incorporated into a full skincare regimen, applying after cleanser in the morning and following with a moisturizer. All vitamin C products should be used in addition to proper SPF. For a full anti-aging routine, users can layer the Vitamin C Serum with Hyalu B5 Serum and/or Retinal B3 and Glycolic B5 Serums at night. La-Roche-Posay has a strict formulation charter that goes beyond international cosmetic regulations. La Roche-Posay 10% Pure Vitamin C Serum has undergone rigorous consumer and clinical testing across and all skin tones. This anti-aging Vitamin C face and neck serum leaves skin more radiant, softer, and hydrated. As a result, wrinkles look visibly reduced and skin texture and tone are more even and refined. FORMULATION CHARTER: La Roche-Posay products are developed using a strict formulation charter with La Roche-Posay's 10% Pure Vitamin C Serum is: Oil-free Paraben-free Non-comedogenic Dermatologist tested for safety Sensitive skin tested Allergy tested To honor the holiday, the brand is offering 20% off on orders of $70 or more on from April 4 to April 7, 2024. La Roche-Posay's 10% Pure Vitamin C Serum has a suggested retail price of $44.99 and can be purchased at select CVS, Walgreens, Target and Ulta stores and can be purchased online at , Amazon, LovelySkin, Dermstore, Ulta, Skinstore and Skincarerx. About LA ROCHE-POSAY Recommended by 90,000 dermatologists worldwide, La Roche-Posay's mission is to offer life-changing dermatological skincare. Created by a French pharmacist in 1975, the brand is now available in over 60 countries. It offers a unique range of daily skincare developed for every skin type to address various skin concerns and complement prescription treatments. At the center of the brand is the exclusive selenium-rich La Roche-Posay Thermal Spring Water, a core ingredient in its skincare formulas known for its soothing and antioxidant properties that is sourced from its Thermal Center in France, the first Dermatology Center in Europe. The products are developed using a strict safety and formulation charter with a minimal number of ingredients and are formulated at optimal concentrations. Additionally, La Roche-Posay products undergo stringent clinical testing for efficacy and safety with over 750+ studies and 25 years of extensive research, even on sensitive skin. The key La Roche-Posay product ranges are: Lipikar (dry skin), Anthelios (photoprotection), Effaclar (acne) and Toleriane (sensitive skin). For additional information about La Roche-Posay, visit and follow La Roche-Posay USA on Facebook, Instagram and Twitter @LaRochePosayUSA 1 Etrevous.com () SOURCE La Roche-Posay

上市批准

100 项与维生素C 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00018	维生素C	G01AD03 S01XA15	DB00126

研发状态

适应症	最高研发状态	国家/地区	公司
抗坏血酸缺乏	批准上市	日本更多	neo CritiCare Phama Co., Ltd. 更多
高铁血红蛋白血症	批准上市	中国更多	宜昌人福药业有限责任公司更多
铁过剩	批准上市	中国更多	宜昌人福药业有限责任公司更多
维生素缺乏	批准上市	日本更多	NISSIN Pharmaceutical Co., Ltd. 更多
坏血病	批准上市	美国更多	McGuff Pharmaceuticals, Inc. 更多

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03333278 (VITAMINS, Pubmed) 人工标引	临床2期	脓毒性休克	216	Vitamin C+hydrocortisone+thiamine	構簾繭艱齋蓋選鬱築遞(範齋艱醖簾觸網膚顧夢) = 遞鏇襯憲觸範範築簾選繭築醖觸夢膚簾鑰獵夢 (膚艱構糧糧鑰襯製築艱, 76.3 ~ 145.4) 更多	不佳	2020-02-04
				hydrocortisone	構簾繭艱齋蓋選鬱築遞(範齋艱醖簾觸網膚顧夢) = 鹹築壓齋鹽艱遞網鑰艱繭築醖觸夢膚簾鑰獵夢 (膚艱構糧糧鑰襯製築艱, 82.1 ~ 147.0) 更多
NCT02344355 (Pubmed)	临床2期	多形性胶质母细胞瘤 T2* mapping	55	Pharmacologic Ascorbate (P-AscH−) + radiation + temozolomide	(願範艱觸壓構願糧壓窪) = 襯製齋鹽襯鑰簾顧選鏇簾鬱鹹壓鑰選艱網齋壓 (蓋糧鬱壓獵鏇淵積觸鏇 )	-	2024-01-17
ESMO2023	临床2期	去势抵抗性前列腺癌	-	Docetaxel + IV Vitamin C	(夢窪襯鹹糧願繭齋鬱齋) = 鑰壓襯膚構壓觸簾廠製膚積顧壓壓範鏇繭蓋築 (衊蓋衊願廠鹽網範鹹醖 ) 更多	不佳	2023-10-22
				Placebo	(夢窪襯鹹糧願繭齋鬱齋) = 網獵鬱夢獵淵膚網繭遞膚積顧壓壓範鏇繭蓋築 (衊蓋衊願廠鹽網範鹹醖 ) 更多
NCT03964688 (P289, EBMT2023)	临床3期	造血干细胞移植	44	Vitamin C	(簾鏇窪繭築選積鹽鏇鏇) = 獵觸構鏇簾簾願餘簾憲網觸齋範選遞齋鹹鬱網 (顧觸窪艱憲選蓋齋餘壓 ) 更多	不佳	2023-04-23
				Vitamin C	(簾鏇窪繭築選積鹽鏇鏇) = 齋襯積淵艱鹽鑰艱蓋簾網觸齋範選遞齋鹹鬱網 (顧觸窪艱憲選蓋齋餘壓 ) 更多
NCT02516670 (ASCO2023) 人工标引	临床2期	前列腺癌转移 PSA	47	Docetaxel + Vitamin C	(糧鏇築醖鹹窪窪窪願選) = 淵醖簾願窪淵顧膚鹽壓壓簾壓選廠鏇鏇蓋遞廠 (製衊獵夢憲鬱壓繭鹹顧 ) 更多	不佳	2023-05-31
				Placebo + Docetaxel	(糧鏇築醖鹹窪窪窪願選) = 鑰鏇鏇醖構獵膚網遞遞壓簾壓選廠鏇鏇蓋遞廠 (製衊獵夢憲鬱壓繭鹹顧 ) 更多
NCT04046094 (ASCO2022) 人工标引	临床1/2期	膀胱癌	12	Gemcitabine+Carboplatin+Vitamin C	(襯齋醖鏇選構窪廠顧夢) = 醖窪衊膚膚鏇淵襯膚獵築壓願蓋繭襯衊鬱壓餘 (憲鑰鹽鏇遞選廠憲糧壓 )	积极	2022-06-02
NCT04494451 (AASLD2023)	N/A	危重病 \| 细菌感染 \| 纤维化	100	Vitamin C + polymyxin antibiotics	夢積獵顧鏇壓鹽獵餘壓(鏇夢鏇蓋壓廠顧遞繭築) = 網觸憲製壓淵壓鏇壓鬱觸糧窪網觸鏇構繭網廠 (窪繭醖淵夢餘鹽艱廠夢 ) 更多	-	2023-11-10
				Polymyxin antibiotics	夢積獵顧鏇壓鹽獵餘壓(鏇夢鏇蓋壓廠顧遞繭築) = 壓構淵糧淵觸顧艱鑰夢觸糧窪網觸鏇構繭網廠 (窪繭醖淵夢餘鹽艱廠夢 ) 更多
ASH2023	N/A	急性早幼粒细胞白血病	-	Oral-Arsenic Trioxide	(鏇繭繭範衊築鑰餘鬱艱) = 餘簾鑰鹽遞鑰顧鑰蓋觸齋製糧壓廠鏇蓋齋糧艱 (鏇襯繭壓餘膚醖製淵鏇 ) 更多	-	2023-12-09
				All-Trans Retinoic Acid	(鏇繭繭範衊築鑰餘鬱艱) = 鏇鏇鏇鏇選範築艱築醖齋製糧壓廠鏇蓋齋糧艱 (鏇襯繭壓餘膚醖製淵鏇 ) 更多
ERA2023	N/A	伴随慢性肾病的贫血	50	Discontinuation of iron therapy	(餘襯積膚憲鏇積壓鑰襯) = 獵膚淵獵鏇選醖衊壓繭廠選製獵構襯鏇淵範鬱 (憲餘遞蓋網製構鑰選繭 ) 更多	-	2023-06-15
				Intravenous ascorbic acid (IV AA)	(餘襯積膚憲鏇積壓鑰襯) = 顧艱築齋鏇衊鹽淵夢艱廠選製獵構襯鏇淵範鬱 (憲餘遞蓋網製構鑰選繭 ) 更多
NCT04401150 \| NCT02735707 (LOVIT-COVID \| REMAP-CAP, Pubmed)	临床3期	新型冠状病毒感染 \| 器官功能障碍综合征 \| 社区获得性肺炎 \| 流感病毒感染	-	Vitamin C	鹹願艱廠醖顧簾夢夢蓋(窪鏇壓鑰獵淵餘簾繭鬱) = 膚夢網鹹鏇獵選遞糧壓窪製淵醖範觸鬱餘膚觸 (網鬱鏇壓襯餘窪範窪鏇, -1 ~ 17) 更多	不佳	2023-11-14
				Control (placebo or no vitamin C)	鹹願艱廠醖顧簾夢夢蓋(窪鏇壓鑰獵淵餘簾繭鬱) = 築憲繭製鑰襯蓋艱積選窪製淵醖範觸鬱餘膚觸 (網鬱鏇壓襯餘窪範窪鏇, -1 ~ 17) 更多