Thymol(Thymol) - 药物靶点：Adiponectin receptors x NF-κB x PPARγ_在研适应症：肥胖_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

Adiponectin receptors x NF-κB x PPARγ

作用机制

脂联素受体激动剂、NF-κB抑制剂(核因子NF-κB复合体抑制剂)、PPARγ激动剂(过氧化物酶体增长因子活化受体γ激动剂)

治疗领域

内分泌与代谢疾病

在研适应症

肥胖

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

7

项与 Thymol 相关的临床试验

IRCT20191106045356N12 / Recruiting临床2/3期IIT

Evaluation of the effectiveness of Thymol vaginal cream on improving symptoms in patients with bacterial vulvovaginitis; A double-blind randomized clinical trial

开始日期2022-08-23

申办/合作机构-

IRCT20191106045356N9 / Suspended临床3期IIT

Preparation and clinical evaluation of a aloe vera and thymol buccal gel for the treatment of aphthous stomatitis: An experimental study and a double blinded randomized clinical trial

开始日期2022-04-03

申办/合作机构-

NCT05427721 / Recruiting临床2期IIT

Thymol Administration Effects on Netrin-1 Serum Concentration on Obese Patients

The prevalence of obesity in Mexico is 35.4%, and it is considered a risk factor for the development of diabetes, systemic arterial hypertension and dyslipidemia. Obesity due to the increased distribution and growth of adipose tissue creates a pro-inflammatory state induced by molecules secreted by the adipocytes themselves. Netrin-1 is a cell migration protein, which directs the recruitment, migration and entrapment of macrophages in different tissues, within adipose tissue the entrapment of macrophages induces the release of pro-inflammatory cytokines, which increase the secretion of pro-inflammatory adipokines. It has been found in high concentration in patients with obesity, insulin resistance and type 2 diabetes. Thymol is a phytopharmaceutical derived from oregano oil that has shown powerful anti-inflammatory and antioxidant effects through the stimulation of PPAR-gamma, adiponectin and inhibition of the NF-κB pathway mediated by the JNK pathway, pathways in which netrin-1 is involved in macrophage entrapment and recruitment.

开始日期2022-04-01

申办/合作机构-

100 项与 Thymol 相关的临床结果

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100 项与 Thymol 相关的转化医学

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100 项与 Thymol 相关的专利（医药）

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3,330

项与 Thymol 相关的文献（医药）

2025-01-01·Talanta

Handshake of deep eutectic solvent and ionic liquid: Two liquid-liquid microextraction procedures for plant analysis

Article

作者: Karpitskiy, Dmitriy Alexeyevich ; Shishov, Andrey Yuryevich ; Bessonova, Elena Andreyevna ; Kartsova, Lyudmila Alexeyevna

Plants are subjects of interest due to the secondary metabolites in their extracts which are promising as new pharmaceuticals. Phytochemistry do not have united system of sample preparation or analysis still due to different structure of plant cells, wide broad range of chemical properties and concentrations of bioactive compounds. Such challenges can be addressed in a green chemistry manner using new approaches through smart materials in routine monitoring and researches. Liquid smart materials, such as ionic liquids (ILs) and deep eutectic solvents (DESs) are attractive due to flexible properties, lots of extraction approaches, recycle potential, and direct compatibility with powerful analytical methods. In this study DES-based microextraction procedure with pH-switching was developed. Four choline chloride DESs were suggested as selective extraction phases for polar compounds from acetonitrile extracts. Method was successfully tested on four plants (Iris sibirica L., Hypericum perforatum L., Scutellaria baicalensis G, Citrus reticulata B.). Developed procedure was optimized and validated for the choline chloride - urea (1:2 mol/mol) DES that demonstrated better results in extraction. LOD for rutin was found as 0.05 mg ml^-1. For low-polar compound, imidazolium ionic liquid-based dispersive liquid-liquid microextraction procedure was developed. 1-hexyl-3-methylimidazolium salts have demonstrated desired selectivity. The main factors influencing the extraction efficiency have been identified and optimized by design of experiment on two model plants (Iris sibirica L. and Scutellaria baicalensis G.). Validation procedures were done for thymol. LOD for thymol was found as 0.021 mg ml^-1. The methods were compared with each other and traditional methanol extraction. The selectivity of the smart materials supports each other, usage of such extraction phases provides same or better results as obtained with methanol.

2025-01-01·Food Chemistry

Protecting anthocyanins of postharvest blueberries through konjac glucomannan/low-acyl gellan gum coatings contained thymol microcapsule during low-temperature storage

Article

作者: Sameen, Dur E ; Lai, Yunya ; Liu, Yaowen ; Xiao, Zhenkun ; Sameen, Dur E. ; Chen, Mingrui ; Rong, Xingyu ; Qin, Wen ; Fu, Fengmei ; Zhu, Huiyan ; Tang, Tingting ; Xie, Jing

In order to protect the anthocyanins in blueberries during low-temperature storage, TMs/KGM/LAG (TKL) coatings were developed by composite thymol/β-cyclodextrin (β-CD) microcapsules (TMs), konjac glucomannan (KGM), and low acyl gellan gum (LAG). The results showed that the TMs prolonged the release of thymol for at least 30 d. The TKL was effective in maintaining the color of blueberry skin by regulating the activities of key enzymes for anthocyanin synthesis and degradation. Among the different treatment groups, TKL60 (thymol concentration of 60 mg/L) was the most effective in protecting anthocyanin. At 42 d of storage, the TKL60 group showed the highest anthocyanin levels of malvidin-3-O-galactoside (718.38 μg/g), delphinidin-3-O-galactoside (343.75 μg/g) and cyanidin-3-O-galactoside (40.67 μg/g). In addition, TKL60 treatment still showed good maintain the qualities of blueberries (weight loss, decay, hardness and TSS). Thus, this study provides a new approach to protect anthocyanin in blueberries after harvest during low-temperature storage.

2025-01-01·Food Microbiology

Antimicrobial activity of essential oil components against Escherichia coli depends on the food components present in a food matrix

Article

作者: Fernández-Segovia, Isabel ; Barat, José M ; Barat, José M. ; González-Bello, Concepción ; Jiménez, M, Consuelo ; Jiménez, M Consuelo ; Gómez-Llorente, Héctor ; Pérez-Esteve, Édgar ; Jiménez, M. Consuelo

Despite numerous studies evaluating the antimicrobial activity of essential oil components (EOCs) against different microorganisms, the effect of the composition of the matrix in which they are applied remains unexplored. Hence, the effect of different food components (i.e., proteins, lipids, carbohydrates, acids, ethanol) on vanillin antimicrobial activity was carried out by assessing the growth of E. coli at different incubation times (0, 1, 4, 8 and 24 h). Based on these outcomes, the food components that most adversely affected vanillin antimicrobial activity were subsequently tested with four other EOCs (i.e., carvacrol, eugenol, geraniol, thymol). The effective concentration of antimicrobials after coming into contact with food components was quantified. The results indicated that bovine serum albumin (BSA), sunflower oil and carbohydrates partially or completely inhibited the antimicrobial efficacy of the tested EOCs, and the inhibition rate depended on the specific EOC-food component combination. Geraniol was notably the most efficient with BSA present. Eugenol performed best with sunflower oil. Carvacrol, eugenol, geraniol and thymol were more effective than vanillin with D-lactose present. This study confirmed that loss of EOCs' effective concentration due to an interaction with food constituents is a significant cause of antimicrobial activity inhibition. These findings underscore the importance of considering matrix composition when selecting antimicrobials to combat a particular strain in real food applications.

100 项与 Thymol 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肥胖	临床2期	墨西哥	-	2022-04-01

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适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ERS2013	N/A	咳嗽	18	Nasal thymol	繭鹽鬱獵願襯膚積襯鬱(簾範夢鏇築繭鏇積餘鹹) = 繭憲餘艱憲網鏇窪繭窪製窪艱製網獵獵艱遞廠 (顧顧膚壓窪遞廠範鹹齋 ) 更多	-	2013-09-01
				Saline	繭鹽鬱獵願襯膚積襯鬱(簾範夢鏇築繭鏇積餘鹹) = 襯繭積獵鑰壓餘夢鹹繭製窪艱製網獵獵艱遞廠 (顧顧膚壓窪遞廠範鹹齋 ) 更多