Two-thirds of the US population, particularly African Americans (AA), is at risk for inadequate or deficient 25-hydroxy-vitamin D (25(OH)VD). Epidemiological studies demonstrate an association between better health outcomes and higher blood levels of 25(OH)VD . Randomized controlled clinical trials have shown that, while supraphysiological high doses of VD are needed to achieve adequate blood levels of 25(OH)VD, not all subjects respond to them. Recent studies have also questioned the therapeutic effects of high-dose VD supplementation. Severe VD deficiency has been associated independently with the future risk of mild cognitive impairment (MCI) and dementia. A reduction in GSH and an increase in the oxidative stress levels of serum, erythrocytes, and circulating lymphocytes has been observed in MCI and Alzheimer disease, findings similar to those in VD deficient persons. Scholarly reviews conclude that excess oxidative stress is one of the major risk factors for AD and support a potential therapeutic role for L-cysteine (LC, a GSH precursor) and vitamin D (VD) supplementation in the treatment of Alzheimer disease symptoms. This application presents the investigators' design for a randomized, double-blind, placebo-controlled clinical trial to test the hypothesis that supplementation with VD in combination with L-cysteine (LC) is more successful at optimizing the statuses of 25(OH)VD [biological signatures] and simultaneously decreasing TNF-α, IR [functional or clinical outcomes], and oxidative stress, suggesting a better therapeutic approach compared with supplementation with VD alone in AA subjects.

开始日期2020-11-06

申办/合作机构

LSU Health Sciences Center

ChiCTR2000029206 / Suspended临床4期IIT

A real-world study for the efficacy and safety of Monoammonium Glycyrrhizinate and Cysteine and Sodium Chloride Injection in patients with perioperative liver injury

开始日期2020-01-06

申办/合作机构

中山大学

PACTR202401759325189 / Completed临床4期IIT

Effect of Myo-Inositol-in combination with alpha-lipoic acid and cysteine (Celine) based co-treatment on Oocyte Quality in Women with Polycystic Ovarian Syndrome Undergoing Assisted Reproductive Technology

开始日期2019-01-02

申办/合作机构-

100 项与盐酸半胱氨酸相关的临床结果

登录后查看更多信息

100 项与盐酸半胱氨酸相关的转化医学

登录后查看更多信息

100 项与盐酸半胱氨酸相关的专利（医药）

登录后查看更多信息

6,655

项与盐酸半胱氨酸相关的文献（医药）

2025-02-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Dual-Channel fluorescent detection of Biothiols: A novel probe for Distinguishing Cysteine, Homocysteine, Glutathione, and N-Acetylcysteine in cellular environments

Article

作者: Wu, Cuiyan ; Yin, Peng ; Huang, Wei ; Yin, Guoxing ; He, Mengxue ; Gan, Yabing ; Chen, Shiying ; Li, Haitao

Biothiols, including cysteine (Cys), homocysteine (Hcy), glutathione (GSH), and N-acetylcysteine (NAC), possess similar chemical structures and properties but play crucial, distinct roles in biological cells and blood serum. Imbalances in the concentrations of these biothiols are associated with various diseases, highlighting the importance of precise discrimination, especially between Cys and other biothiols. Owing to the similarity of the chemical properties of Cys, Hcy, GSH, and NAC, developing an effective methodology to differentiate these thiol compounds is challenging. In this study, we designed and synthesized a novel dual-channel fluorescent probe, hereafter referred to as CNTC, by integrating coumarin and acrylonitrile. This probe enabled the simultaneous discrimination of Cys from Hcy, GSH, and NAC, producing distinct fluorescent signals: blue for Cys and green for Hcy, GSH, and NAC. CNTC exhibited rapid response kinetics (within 30 min) and impressive detection limits of 0.31, 0.11, 0.029, and 0.032 μM for Cys, Hcy, GSH, and NAC, respectively. Furthermore, CNTC was successfully applied in the fluorescence imaging of both exogenous and endogenous Cys, Hcy, GSH, and NAC in living cells. The remarkable analytical and bioimaging capabilities of CNTCin vivo establish it as a promising tool for elucidating the pathophysiological roles of biothiols, particularly Cys, Hcy, GSH, and NAC.

2025-01-01·Biosensors and Bioelectronics

An AIE-based ratiometric fluorescent probe for highly selective detection of H2S in plant stress responses

Article

作者: Yang, Xiaopeng ; Sun, Kai ; Ye, Yong ; Luo, Fei ; Zhang, Shiyi ; Lai, Miao ; Ji, Xiaoming ; Zhang, Ying ; Yan, Dingwei

Hydrogen sulfide (H₂S) has emerged as a crucial signaling molecule in plant stress responses, playing a significant role in regulating various physiological and biochemical processes. In this study, we report an aggregation-induced emission (AIE)-based ratiometric fluorescent probe TPN-H₂S for the highly selective detection of H₂S in plant tissues. The probe exhibited excellent sensitivity and selectivity towards H₂S over other analytes, enabling real-time monitoring of H₂S dynamics in living cell. Furthermore, the AIE-based ratiometric probe TPN-H₂S allowed for accurate quantification of H₂S levels, providing valuable insights into the spatiotemporal distribution of Cys metabolism produces H₂S. Importantly, the physiological pathways and signaling mechanisms of H₂S production of was investigated in plant tissues under Cr and nano-plastics stress. Utilizing a high-throughput screening approach, we identified exogenous substances such as calcium chloride (CaCl₂) and abscisic acid (ABA) that could induce higher level of H₂S production during the stress response in plants. Overall, those findings demonstrate the potential of the AIE-based ratiometric fluorescent probe TPN-H₂S as a powerful tool for unraveling the role of H₂S in plant stress responses and pave the way for further exploration of H₂S-mediated signaling pathways in plants.

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Simultaneous detection of cysteine and glutathione in food with a two-channel near-infrared fluorescent probe

Article

作者: Zhang, Jin ; Chen, Hong ; Hu, Xichao ; Duan, Ruizhe ; Wang, Jiali ; Zeng, Lintao ; Li, Mingchao

L-Cysteine (Cys) and glutathione (GSH) are closely related biological species that widely exist in food and living cells. To simultaneously detect Cys and GSH from different emission channels, we developed a fluorescent probe (BDP-NBD) based on near-infrared BODIPY and 7-nitrobenzofurazan (NBD). Upon nucleophilic substitution reaction with GSH, BDP-NBD generated an emission band at 713 nm, which can be used to determine GSH (0-100 μM) with a low detection limit (34 nM). Different from GSH, BDP-NBD underwent a nucleophilic substitution-rearrangement reaction with Cys, affording two emission bands at 550 nm and 713 nm, respectively. BDP-NBD was successfully employed to quantify Cys and GSH in various food samples with good recoveries (86.6%-104.6%). Besides, BDP-NBD can image Cys and GSH in living cells from two emission channels. Therefore, this work developed a tool for the simultaneous determination of Cys and GSH in both food and living cells so as to ensure food safety and human health.

项与盐酸半胱氨酸相关的新闻（医药）

2024-10-30

·生物探索

Nat Commun | 魏民/王杨团队与巴雪青团队合作揭示甲硫氨酸-SAM代谢依赖的泛醌合成对铁死亡诱导中ROS的积累至关重要

引言铁死亡（Ferroptosis）是区别于细胞凋亡、坏死、自噬的一种新型调节性的细胞死亡方式【1】，由铁依赖的脂质过氧化物积累所导致，铁死亡的诱发在许多疾病（如缺血再灌注心肌损伤、神经退行性病变、自身免疫性以及传染性疾病）中起关键致病作用【2,3】，同时也是临床中治疗肿瘤的新型手段【4,5】。诱发细胞铁死亡的主要因素包括ROS（•OH）、含有多不饱和脂肪酸的磷脂（PUFA-PL）和Fe2+，因而铁死亡严格受到氧化还原稳态、铁代谢和脂代谢的调控。近年来，糖代谢和氨基酸代谢对铁死亡的调控作用也日渐凸显，但具体精细的调节机制很大程度上仍然未知。 2024年10月17日，东北师范大学分子表观遗传学教育部重点实验室魏民/王杨团队与巴雪青团队合作在Nature Communications上发表了题为Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction的研究论文，系统地报道了甲硫氨酸衍生的S-腺苷甲硫氨酸（S-adenosylmethionine, SAM）促进电子载体泛醌（Ubiquinone, UQ）的合成及线粒体ROS的产生，是细胞发生铁死亡的必要条件。铁死亡的根本诱因是由于细胞的氧化还原平衡被打破，导致ROS的大量积累，进而产生过量的脂质过氧化物所致。细胞内的抗氧化系统可还原脂质过氧化物防御细胞发生铁死亡，其中Cyst(e)ine/GSH/GPX4系统是目前公认的最主要的铁死亡防御系统。过氧化物酶（GPX4）利用其底物谷胱甘肽（GSH）提供的电子将过氧化的脂质还原为无毒性的脂质醇，从而达到清除脂质过氧化物的目的，使细胞免于铁死亡【6-10】。GSH是Cyst(e)ine/GSH/GPX4系统中核心的抗氧化物质，由半胱氨酸（Cysteine, Cys）、甘氨酸和谷氨酸三种氨基酸组成。虽同为非必需氨基酸，但Cys的巯基是GSH抗氧化能力的来源，正因如此Cys是GSH合成的限制性底物，Cys的可获得性是GSH合成的限制因素。已知细胞中存在两种途径获取Cys：以胱氨酸为基础的半胱氨酸的外源吸收途径和以甲硫氨酸（Methionine, Met）为基础的半胱氨酸的内源合成途径。然而，在目前铁死亡研究中，仅限制Cys外源吸收途径即可诱导细胞发生铁死亡。那么，以Met为基础的Cys内源合成途径在此过程中为什么无法有效防御铁死亡呢？Met与铁死亡的发生到底是什么关系呢？该研究发现，即使使用远高于生理浓度的Met，也并没有缓解细胞内Cys和GSH的耗竭，同时也未对细胞铁死亡产生缓解作用，这说明，由Met生成的Cys的途径可能是受阻的。随后该研究发现，由Met生成的Cys的内源合成途径具有肝脏组织特异性。同时，研究还意外地发现，Met不仅不能通过内源合成途径生成Cys抑制细胞铁死亡，反而Met的存在是细胞铁死亡发生所必需的，Met衍生的SAM是调节铁死亡的关键代谢物，以SAM为基础的甲基化修饰作用促进了线粒体电子传递链中电子载体UQ的合成及线粒体ROS的产生，从而参与铁死亡的发生。小鼠体内的实验结果显示，注射SAM能增效铁死亡诱导剂Imidazole Ketone Erastin（IKE）引起的肿瘤细胞内铁死亡水平并进一步抑制肿瘤生长；灌胃MAT2A的抑制剂FIDAS-5，即抑制Met向SAM的转化，能降低小鼠心肌细胞铁死亡水平并缓解阿霉素Doxorubicin（DOX）诱导的心肌损伤。模式图（Credit: Nature Communications）综上所述，该研究从探究甲硫氨酸向半胱氨酸转化的内源合成途径在防御铁死亡中的可能作用切入，但预期之外地发现Met不但不能通过合成半胱氨酸抑制铁死亡，反而通过增加电子载体泛醌的合成贡献于线粒体ROS的产生和积累，且对铁死亡的发生至关重要。此项研究为深刻认识氨基酸调控铁死亡的作用提供新理解，并为铁死亡相关病理干预提供新策略。参考文献 1. Dixon, S.J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060-1072 (2012). 2. Gao, M., Monian, P., Quadri, N., Ramasamy, R. & Jiang, X. Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell 59, 298-308 (2015). 3. Friedmann Angeli, J.P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16, 1180-1191 (2014). 4. Jiang, L. et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520, 57-62 (2015). 5. Badgley, M.A. et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368, 85-+ (2020). 6. Ingold, I. et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. CELL 172, 409-422 (2018). 7. Tang, D., Chen, X., Kang, R. & Kroemer, G. Ferroptosis: molecular mechanisms and health implications. Cell research 31, 107-125 (2021). 8. Hassannia, B., Vandenabeele, P. & Vanden Berghe, T. Targeting Ferroptosis to Iron Out Cancer. Cancer cell 35, 830-849 (2019). 9. Dixon, S. & Olzmann, J. The cell biology of ferroptosis. Nature reviews. Molecular cell biology (2024). 10. Stockwell, B. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401-2421 (2022). https://www.nature.com/articles/s41467-024-53380-5 责编|探索君排版|探索君来源|BioArt End 往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文 Cell | 是什么决定了细胞的大小？热文 Nature | 2024年值得关注的七项技术热文 Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文 CRISPR技术进化史 | 24年Cell综述

核酸药物申请上市

2024-10-22

·药通社

【论药海南】专供特色化学原料药-山西阳和药业，涉及呼吸系统、消化系统等领域

2023年12月3-4日 2024MAH&DDS制剂合作大会·海南站展位号：37号公司简介山西阳和药业有限公司成立于2017年，坐落于山西省大同市阳高县龙泉工业园区。公司注册资本5100万元，总占地面积100亩。阳和药业作为化学原料药的商业化生产基地，专业从事特色化学原料药的研发、生产、销售。公司现拥有多条原料药生产线，产品涉及呼吸系统、消化系统等多个领域。目前公司可大批量生产乙酰半胱氨酸、间苯三酚、间苯三酚三甲醚、聚乙烯醇等原料药。 COMPANY PROFILE Shanxi Yanghe Pharmaceutical Co., Ltd. was established in 2017 and is located in Longquan lndustrial Park, Yanggao County, Datong city, shanxi Province. The registered capital of the company is 51 million yuan, and the total area is 100 acres.As a commercial production base of chemical APls, Yanghe Pharmaceutical specializes in the R&D, production and sales of specialty chemical APls. The company now has a number of API production lines, and its products involve respiratory system, digestive system and other fields. At present,the company can produce acetylcysteine, resorcinol, and resorcinol trimethyl ether in large quantities, polyvinyl alcohol and other APls. 公司团队公司拥有一支年轻有干劲的新型团队；建立了完善的生产和质量管理体系；公司建有多个原料药多功能车间，实现从小试研究、中试放大、注册申报、大规模生产的一条龙服务；严格的质量控制，完善的检验设施和仪器设备，严密的质量保证系统，能够有效保障法规符合性、CFDl注册核查和客户审计的要求。 COMPANY TEAM The company has a young and energetic new team, has established a sound production and QMS system, the company has built a number of APl multifunctional workshops, to achieve a small test research, pilot scale-up, registration declaration, large-scale production one-stop service, strict QC, perfect inspection facilities and equipment, strict QA system, can effectively ensure regulatory compliance,CFDl registration verification and customer audit requirements. 01 乙酰半胱氨酸化学名：N-乙酰基-L-半胱氨酸 CAS No.: 616-91-1 登记号：Y20210001235 用途：呼吸系统药物，具有祛痰的作用，其注射液用于肝衰竭早期治疗，也可用于配置复合氨基酸输液、特医食品及保健品。符合ChP2020年版、BP2022、EP10.8、JPX VlII、USP-NF2022药典标准；已获得GMP、CP Chemical name: N-acetyl-L-cysteine CAS No.: 616-91-1 Registration No.: Y20210001235 Uses: Respiratory system drug, with expectorant effect, its injection for the early treatment of liver failure, can also be used to configure complex amino acid infusion, special medical food and health care products. In accordance with ChP2020、BP2022、EP10.8、JPX VlII、USP-NF2022；GMP and CP have been obtained 02 间苯三酚三甲醚化学名：1，3，5-三甲氧基苯 CAS NO.: 621-23-8 登记号：Y20220000338 用途：消化系统和胆道功能障碍引起的急性痉挛性疼痛；急性痉挛性尿道、膀胱、肾绞痛；妇科痉挛性疼痛已获得GMP、CP Chemical name: 1,3,5-Trimethoxybenzene CAS No.: 621-23-8 Registration No.: Y20220000338 Uses: Acute spasmodic pain caused by digestive system and biliary tract dysfunction; Acute spastic colic of urethra, bladder and kidney; Gynecologic spasmodic pain GMP and CP have been obtained 03 间苯三酚化学名：苯基-1，3，5-三酚二水合物 CAS No.: 6099-90-7 登记号：Y20220000471 用途：消化系统和胆道功能障碍引起的急性痉挛性疼痛；急性痉挛性尿道、膀胱、肾绞痛；妇科痉挛性疼痛符合BP2022、EP10. 8药典标准；已获得GMP、CP Chemical name: Benzene-1,3,5-triol dihydrate CAS No.: 6099-90-7 Registration No.: Y20220000471 Uses: Acute spasmodic pain caused by digestive system and biliary tract dysfunction; Acute spastic colic of urethra, bladder and kidney; Gynecologic spasmodic pain In accordance with BP2022, EP10.8；GMP and CP have been obtained 04 聚乙烯醇化学名：聚乙烯醇 CAS NO.: 9002-89-5 用途：用于润滑和滋润眼睛表面，有助于暂时缓解干眼症（DED）或环境因素引起的干燥、刺激、灼热、不适和/或任何其他症状符合ChP2020年版、BP2022、EP10.8、USP-NF2022药典标准；已获得GMP Chemical name: Poly(vinyl alcohol) macromolecule CAS No.: 9002-89-5 Use: To lubricate and moisturize the surface of the eye to help temporarily relieve dryness, irritation, burning, discomfort and/or any other symptoms of dry eye (DED) or environmental factors。 In accordance with ChP2020、BP2022、EP10.8、USP-NF2022；GMP have been obtained 联系方式周女士13306586060 薛女士15958675001 点击查看大会详情 ▽ 立即扫码报名 ▽

2024-09-27

·生物探索

Mol Cell | OPA1协调线粒体ROS和整合应激反应调控细胞铁死亡

引言铁死亡是一种铁依赖的非凋亡性细胞死亡形式，这种细胞死亡形式与传统的细胞凋亡、坏死等形式不同，主要由细胞内铁的积累以及脂质过氧化引发【1, 2】。细胞内存在抗氧化机制试图抑制这些氧化物的积累，其中谷胱甘肽过氧化物酶4（GPx4）是抵御铁死亡的主要防御机制之一，它是一种PL氢过氧化物酶，利用谷胱甘肽（GSH）作为辅助因子催化氧化脂质的还原【3, 4】。GSH的生成依赖于半胱氨酸的供应，而半胱氨酸通过细胞膜上的转运体导入细胞，一旦GSH耗尽，GPx4无法正常发挥功能，细胞将变得易于发生铁死亡【5】。线粒体是活性氧（ROS）生成的主要场所，高水平的ROS会导致细胞的氧化性死亡，而抑制线粒体ROS特别是脂质ROS可以减轻铁死亡，说明线粒体在直接促进脂质过氧化中起到的关键作用。但是，关于线粒体如何调控铁死亡的具体仍然未知。近日，来自美国阿尔伯特-爱因斯坦医学院的Richard N. Kitsis在Molecular Cell上发表了论文OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response。在本研究中，作者探究了线粒体蛋白OPA1在调控铁死亡中的作用，研究发现OPA1能通过调节线粒体ROS和整合应激反应来调控细胞对铁死亡的敏感性。 OPA1是一种线粒体动力蛋白样GTP酶，负责线粒体形态发生、融合和能量动力学。鉴于OPA1在控制线粒体结构和能量方面的作用，作者推测OPA1可能是通过线粒体依赖机制来调节铁死亡的关键节点。为了研究OPA1在铁死亡中的作用，作者使用了小鼠胚胎成纤维细胞（MEFs）和人类U2OS骨肉瘤细胞，并在这两种细胞中分别敲除Opa1，通过三种方法（半胱氨酸剥夺、小分子抑制剂诱导和脂质过氧化检测）诱导铁死亡。研究发现，OPA1的缺失可以显著减少脂质过氧化和由多种铁死亡诱导剂引起的细胞死亡。这表明OPA1可能是铁死亡的一个正调控因子，在铁死亡中起到促进作用。此外，OPA1的GTPase活性在这个过程中十分重要，GTPase功能缺陷突变体（K301A）不能拯救Opa1缺失导致的铁死亡抑制。研究人员进一步的机制研究发现，OPA1促进铁死亡的能力与其促进线粒体融合的能力无关，因为在缺失Opa1的细胞中表达L-OPA1（具有促进线粒体融合能力）和S-OPA1（不具有促进线粒体融合能力）两种异构体时，所有细胞的死亡率相似，脂质过氧化水平也无显著差异。除了介导线粒体融合外，OPA1还调控线粒体嵴的超微结构、电子传递链复合物（ETC）的组装以及氧化磷酸化。因此，缺失Opa1导致线粒体嵴的结构混乱和ETC I、III、IV和V的组装受损，但不影响复合物II的组装。有趣的是，OPA1在通过半胱氨酸剥夺和xGT抑制剂（erastin）导致的线粒体ROS和脂质ROS积累中发挥作用，而在通过GPx4抑制剂（RSL3）引发的ROS积累中不发挥作用。这种差异性解释了为什么Opa1缺失的MEFs对erastin诱导的铁死亡比对RSL3更具抗性。为了理解OPA1缺失如何赋予细胞对铁死亡的抗性，研究人员接下来探究了OPA1缺失是否影响xCT-GSH-GPx4通路。研究发现，OPA1的缺失上调了xCT基因的转录和活性，进而GSH水平也得到提升。更加重要的是，OPA1缺失细胞表现出更高的GPx4蛋白水平，并在erastin和RSL3处理期间GPx4水平并没有很快的下降，这与细胞对铁死亡的抗性一致。敲低xCT基因使得OPA1缺失细胞对铁死亡的抗性消失，细胞重新变得对铁死亡敏感。这些结果表明，OPA1缺失通过上调xCT-GSH-GPx4通路赋予细胞对铁死亡的抗性。研究人员随后通过RNA-seq分析发现，ATF4转录因子是整合应激反应的关键转录激活因子，能够上调一些铁死亡抗性相关基因（如xCT基因）的表达，OPA1的缺失导致ATF4表达上调以及整合应激反应的激活。文章的最后，作者还探究了OPA1对脂质代谢的影响。通过脂质组学分析，磷脂、溶血磷脂、甘油酯、游离脂肪酸和鞘脂在OPA1缺失的细胞中表现出显著变化。其中，多不饱和脂肪酸的某些种类表现出减少的现象，大多数单不饱和脂肪酸则显著富集。多不饱和脂肪酸在铁死亡过程中特别容易发生过氧化，而单不饱和脂肪酸可以减少细胞膜上脂质过氧化的积累，这表明单不饱和脂肪酸的积累可能在抑制铁死亡中发挥了潜在作用。模式图（Credit: Molecular Cell）参考文献 https://www.nature.com/articles/d41591-024-00013-5 1. Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., Skouta, R., Zaitsev, E.M., Gleason, C.E., Patel, D.N., Bauer, A.J., Cantley, A.M., Yang, W.S., et al. (2012). Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072. 2. Dixon, S.J., and Stockwell, B.R. (2019). The hallmarks of ferroptosis. Annu. Rev. Cancer Biol. 3, 35–54. 3. Yang, W.S., SriRamaratnam, R., Welsch, M.E., Shimada, K., Skouta, R., Viswanathan, V.S., Cheah, J.H., Clemons, P.A., Shamji, A.F., Clish, C.B., et al. (2014). Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331. 4. Seiler, A., Schneider, M., Fo ̈ rster, H., Roth, S., Wirth, E.K., Culmsee, C., Plesnila, N., Kremmer, E., Ra ̊ dmark, O., Wurst, W., et al. (2008). Glutathione peroxidase 4 senses and translates oxidative stress into 12/ 15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, 237–248 5. Poltorack, C.D., and Dixon, S.J. (2022). Understanding the role of cysteine in ferroptosis: progress & paradoxes. FEBS Journal 289, 374–385. https://doi.org/10.1016/j.molcel.2024.07.020 责编|探索君排版|探索君文章来源|“BioArt” End 往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文 Cell | 是什么决定了细胞的大小？热文 Nature | 2024年值得关注的七项技术热文 Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文 CRISPR技术进化史 | 24年Cell综述

100 项与盐酸半胱氨酸相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D02326	盐酸半胱氨酸	A16AA	DB00151

研发状态

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
营养紊乱	美国	Exela Pharma Sciences LLC	2019-04-16
肿瘤	中国	陕西汉唐制药有限公司	1982-01-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASGCT2020	N/A	-	-	Glutamate-Cysteine Ligase Modifi er Subunit	鑰糧積範艱憲鏇鏇醖築(廠觸齋壓淵願鹽構齋築) = Cell death and proliferation in all cell cultures were in an AUC-dependent manner 遞壓積願築鹽遞鹽觸範 (糧壓願襯衊選齋構窪構 ) 更多	-	2020-04-28
				Glutamate-Cysteine Ligase Modifi er Subunit
ARVO2015	N/A	-	-	L-cysteine	蓋鹹憲衊顧壓蓋窪膚鬱(選襯衊鏇衊遞淵齋範壓) = 襯廠積構夢遞鬱衊衊積艱艱鬱糧顧選網淵遞築 (膚廠網繭顧鹹顧構製鏇 )	-	2015-06-01
				Anandamide	蓋鹹憲衊顧壓蓋窪膚鬱(選襯衊鏇衊遞淵齋範壓) = 廠範網襯蓋糧築衊餘選艱艱鬱糧顧選網淵遞築 (膚廠網繭顧鹹顧構製鏇 )
ARVO2011	N/A	视网膜疾患 CD34+	-	Cysteine-Rich Protein 61 (CCN1/Cyr61)	(蓋願壓鏇鑰觸範構願積) = 選艱廠選膚簾鹽鑰遞願積願餘範憲積衊艱遞網 (鬱膚齋夢衊製廠蓋醖獵 )	-	2011-04-01
				Cysteine-Rich Protein 61 (CCN1/Cyr61)	(蓋願壓鏇鑰觸範構願積) = 鹽網範夢簾窪積憲遞範積願餘範憲積衊艱遞網 (鬱膚齋夢衊製廠蓋醖獵 )