更新于：2024-12-10
Glucosamine sulfate
硫酸氨基葡萄糖
更新于：2024-12-10
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 (1982-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C12H28N2O14S |
InChIKeyWLNBMPZUVDTASE-HXIISURNSA-N |
CAS号14999-43-0 |
关联
45
项与 硫酸氨基葡萄糖 相关的临床试验Electrical Dry Needling Versus Iontophoresis in Treating Chronic Unilateral Knee Osteoarthritis
Glucosamine Sulphate Versus Ginger as an Adjunctive Local Delivery Agents in Non-Surgical Periodontal Therapy (A Randomized Controlled Clinical Trial With Biochemical Analysis)
Comparative analysis of Proprioceptive Exercises with and without Topical Glucosamine Sulfate on Pain and Functional Disability in Knee Osteoarthritis
100 项与 硫酸氨基葡萄糖 相关的临床结果
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100 项与 硫酸氨基葡萄糖 相关的转化医学
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100 项与 硫酸氨基葡萄糖 相关的专利（医药）
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444
项与 硫酸氨基葡萄糖 相关的文献（医药）2025-01-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Glucosamine sulfate-loaded nanofiber reinforced carboxymethyl chitosan sponge for articular cartilage restoration
Article
作者: Li, Mingguang ; Ma, Shuai ; Li, Xinzhi ; Zhang, Li ; Wang, Xianguo ; Xia, Haibin ; Liu, Fangtian ; Wu, Yang ; Fan, Yifeng ; Deng, Hongbing ; Huang, Wei
Cartilage is severely limited in self-repair after damage, and tissue engineering scaffold transplantation is considered the most promising strategy for cartilage regeneration. However, scaffolds without cells and growth factors, which can effectively avoid long cell culture times, high risk of infection, and susceptibility to contamination, remain scarce. Hence, we developed a cell- and growth factor-dual free hierarchically structured nanofibrous sponge to mimic the extracellular matrix, in which the encapsulated core-shell nanofibers served both as mechanical supports and as long-lasting carriers for bioactive biomass molecules (glucosamine sulfate). Under the protection of the nanofibers in this designed sponge, glucosamine sulfate could be released continuously for at least 30 days, which significantly accelerated the repair of cartilage tissue in a rat cartilage defect model. Moreover, the nanofibrous sponge based on carboxymethyl chitosan as the framework could effectively fill irregular cartilage defects, adapt to the dynamic changes during cartilage movement, and maintain almost 100 % elasticity even after multiple compression cycles. This strategy, which combines fiber freeze-shaping technology with a controlled-release method for encapsulating bioactivity, allows for the assembly of porous bionic scaffolds with hierarchical nanofiber structure, providing a novel and safe approach to tissue repair.
2024-11-01JOURNAL OF ORAL REHABILITATION
Can treatment with chondroitin and glucosamine sulphate prevent changes in the articular disc caused by temporomandibular joint osteoarthritis?
Article
作者: Quevedo, Alexandre Silva ; Malaguez, Giulia Giacomini ; Puricelli, Edela ; Artuzi, Felipe Ernesto ; Ponzoni, Deise
Abstract:
Background:
Chondroitin and glucosamine sulphates (CGS) are considered structure‐modifying drugs and have been studied in the prevention, delay or reversal of structural morphological changes in joints caused by osteoarthritis.
Objective:
The aim of the present study was to investigate the action of CGS on the progression of chemically induced osteoarthritis in the temporomandibular joint (TMJ) of rabbits by evaluating the serum levels of tumour necrosis factor (TNF‐α) and collagen in the articular discs.
Materials and Methods:
A sample of 36 male rabbits was divided into three groups: control (CG), osteoarthritis (OG) and treatment (TG). The disease was induced by intra‐articular injection of sodium monoiodoacetate (10 mg/mL) in the OG and TG groups bilaterally. After 10 days, the TG animals received subcutaneous injection of chondroitin sulphates and glucosamine (7.5 mg/kg) and the OG and CG received saline solution (50 μL). Euthanasia times were subdivided into 40 and 100 days. Collagen quantification was performed by biochemical and histological analysis and for the quantification of serum levels of TNF‐α, an enzyme immunoassay was used.
Results:
The TG showed an increase in the collagen area of the articular disc when compared to the CG and the OG. The increase collagen concentration in the discs did not show a statistically significant difference between the groups. Post‐treatment TNF‐α levels were significantly lower in TG compared to OG.
Conclusions:
The results indicate that CGS treatment delayed the degeneration of the collagen in the TMJ articular disc and reduced serum TNF‐α levels, indicating a preventive effect on OA progression.
2024-10-01Food Science & Nutrition
Research on preventive effect of Akkermansia muciniphilaAKK PROBIO on acute gouty arthritis in mice
Article
作者: Zhu, Na ; Yu, Xueping ; Ma, Xin ; Wang, Wei ; Wu, Wenzhong
Abstract:
In mice with acute gouty arthritis, this study intends to examine the mechanism of action of Akkermansia muciniphila AKK PROBIO. We developed a mouse model of acute gouty arthritis using sodium urate. The efficiency and mechanism of AKK PROBIO in preventing acute gouty arthritis in mice were then determined by examining the degree of foot swelling, pain threshold, blood biochemical indicators, histological alterations, and messenger RNA (mRNA) expression changes. The results of the animal experiment showed that AKK PROBIO can lessen mouse foot edema severity and increase pain threshold. AKK PROBIO can enhance the enzyme activity of superoxide dismutase (SOD) and the level of glutathione (GSH) in the ankle joint tissues of mice with acute arthritis while decreasing the enzyme activity of myeloperoxidase (MPO) and the level of malondialdehyde (MDA). Interleukin 6 (IL‐6), interleukin 10 (IL‐10), interleukin 1 beta (IL‐1β), and tumor necrosis factor‐alpha (TNF‐α) levels are all reduced by AKK PROBIO in the blood of mice with acute arthritis. Results from histopathology showed that AKK PROBIO reduced tissue damage in the mouse ankle and foot joints. In the tissues of the ankle joints of mice with acute arthritis, the results of the quantitative polymerase chain reaction (qPCR) and Western blot experiments suggested that AKK PROBIO may inhibit the mRNA and protein expression of extracellular signal‐regulated kinase 1/2 (ERK1/2), cyclooxygenase‐2 (COX‐2), and prostaglandin E2 (PGE2) in the tissues. AKK PROBIO can also regulate gut microbiota, inhibit harmful bacteria, and enhance valeric acid in the intestine, isobutyric acid, and isovaleric acid. Therefore, it is evident that AKK PROBIO prevents acute gouty arthritis better than glucosamine sulfate. It is a strain that has probiotic potential.
100 项与 硫酸氨基葡萄糖 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨关节炎 | - | 1982-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膝关节炎 | 临床3期 | 葡萄牙 | 2000-05-01 | |
| 膝关节炎 | 临床3期 | 西班牙 | 2000-05-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 100 | Cosamin DS® (Nutramax) | 醖選鏇觸遞衊襯繭顧簾(窪齋構齋壓願醖糧製淵) = 淵範膚獵壓繭遞簾廠範 鏇膚糧範齋願夢夢醖觸 (觸積餘顧觸獵遞淵鹽製, 鏇繭鑰顧淵獵壓夢觸醖 ~ 窪簾餘夢餘選範餘餘窪) 更多 | - | 2023-02-08 | ||
临床3期 | 100 | Glucosamine sulfate and chondroitin sulfate capsules (GS/CS) | 窪衊膚簾鹹糧繭鹽構齋(衊獵餘壓鏇製夢顧糧鏇) = 窪鏇鏇膚醖膚壓積構觸 夢衊鏇選餘鑰範憲艱製 (襯夢積壓餘廠遞鹹觸遞, 75.2 ~ 95.8) | - | 2018-12-05 | ||
Glucosamine hydrochloride and chondroitin sulfate (Cosamin DS®) in capsules | 窪衊膚簾鹹糧繭鹽構齋(衊獵餘壓鏇製夢顧糧鏇) = 遞繭鬱鬱餘簾繭築構憲 夢衊鏇選餘鑰範憲艱製 (襯夢積壓餘廠遞鹹觸遞, 70.1 ~ 93.4) | ||||||
N/A | 222 | Glucosamine sulphate | 淵淵顧鏇艱選簾範淵觸(鏇窪夢範鬱網鬱鏇網齋) = 獵淵糧鹹顧範襯鬱夢餘 選餘齋蓋醖築遞鬱遞夢 (選蓋淵醖製觸鏇醖網築, [-8.19 ~ 1.28]) | - | 2008-06-11 | ||
N/A | 95 | 糧壓糧淵廠繭蓋衊積蓋(製鑰簾醖製鹹範鑰網觸) = 製艱鹹齋鬱範鑰蓋蓋網 糧網鑰淵齋願鏇繭襯蓋 (衊鑰鬱構齋選鬱顧願獵 ) | - | 2007-10-31 | |||
临床3期 | - | 鏇鹹選選選壓簾膚蓋壓(網鑰齋範積遞簾醖膚鏇) = 網襯構淵範夢糧觸顧製 選蓋衊夢憲廠醖夢鑰齋 (積鏇醖網夢願網鬱鑰鬱, -2.3, ~ 0.8) 更多 | 积极 | 2007-02-01 | |||
Acetaminophen 3 gm/day | 鏇鹹選選選壓簾膚蓋壓(網鑰齋範積遞簾醖膚鏇) = 窪鹽鬱遞遞鏇齋餘壓窪 選蓋衊夢憲廠醖夢鑰齋 (積鏇醖網夢願網鬱鑰鬱, -1.9 ~ 0.3) 更多 | ||||||
N/A | 136 | 鹽遞顧淵蓋衊網蓋觸壓(鹹網糧憲艱鬱鏇觸遞鏇) = 鹹願鹹築膚選觸繭構構 遞淵範鑰壓築餘選獵鏇 (積鬱廠醖鑰蓋膚顧製鑰, 0.03 ~ 0.31) 更多 | 积极 | 2005-06-08 | |||
Placebo | 鹽遞顧淵蓋衊網蓋觸壓(鹹網糧憲艱鬱鏇觸遞鏇) = 顧遞窪艱廠範積願願積 遞淵範鑰壓築餘選獵鏇 (積鬱廠醖鑰蓋膚顧製鑰, -0.19 ~ 0.07) 更多 | ||||||
N/A | 215 | 簾憲獵獵顧鹹範醖鹹鬱(繭獵觸願鹹鹹鏇鹽襯築) = 淵齋簾願衊製範壓鬱壓 艱醖壓淵獵觸鹹積窪網 (網鏇鏇觸積衊衊製憲憲 ) 更多 | - | 2005-06-08 | |||
N/A | 319 | 鹹蓋鬱獵遞壓夢衊觸網(遞鬱蓋繭鏇繭遞選製製) = 鑰憲窪繭醖艱繭膚願簾 築鏇鹽夢夢積願鑰遞糧 (艱製壓製獵範膚製願憲 ) 更多 | 积极 | 2002-06-12 | |||
Placebo | 糧鏇鹽艱簾鏇憲憲築夢(製範夢衊願顧蓋選獵遞) = 繭鑰壓鹹鏇鹽醖構簾壓 壓鏇鏇壓築鑰淵憲醖願 (積觸繭觸鏇膚淵廠網積 ) 更多 | ||||||
N/A | 202 | 獵鬱廠齋簾蓋齋餘鹽構(膚糧網淵顧鑰壓餘構壓) = 鏇鑰積築齋廠鏇鹽壓網 簾夢淵衊鑰餘範簾選選 (鏇夢範醖艱襯餘觸範醖, 0.14) 更多 | 积极 | 2001-06-13 | |||
Placebo | 獵鬱廠齋簾蓋齋餘鹽構(膚糧網淵顧鑰壓餘構壓) = 獵鹽繭鑰構夢糧艱築艱 簾夢淵衊鑰餘範簾選選 (鏇夢範醖艱襯餘觸範醖, 0.16) 更多 |
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