A double-blind, placebo-controlled, randomized, parallel-group study evaluating the efficacy and tolerability of oral BVT.115959, a novel A2A agonist, versus placebo in the treatment of diabetic neuropathic pain

开始日期2007-06-20

申办/合作机构

Swedish Orphan Biovitrum AB

NCT00452777 / Completed临床2期

A Double-blind, Placebo-controlled, Randomized, Parallel-group Study Evaluating the Efficacy and Tolerability of Oral BVT.115959, a Novel A2A Agonist, Versus Placebo in the Treatment of Diabetic Neuropathic Pain

The purpose of this study is to evaluate the efficacy and tolerability of BVT.115959 in diabetic patients with neuropathic pain who are either not on analgesia or are on stable analgesia in the month prior to entering the study.

开始日期2007-05-01

申办/合作机构

Swedish Orphan Biovitrum AB

100 项与 Spongosine 相关的临床结果

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100 项与 Spongosine 相关的转化医学

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100 项与 Spongosine 相关的专利（医药）

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项与 Spongosine 相关的文献（医药）

2015-03-27·Journal of natural products2区 · 生物学

Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta

2区 · 生物学

Article

作者: Lee, John ; Bertin, Matthew J. ; Dorrestein, Pieter C. ; Korobeynikov, Anton ; Gerwick, Lena ; Schwartz, Sarah L. ; Gerwick, William H.

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

2011-03-01·Mini reviews in medicinal chemistry3区 · 医学

Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates

3区 · 医学

Review

作者: Proksch, P. ; Ebada, S. S.

Natural Guanidines from marine invertebrates represent a group of bioactive secondary metabolites that revealed prominent pharmacological activities such as antimicrobial, antiproliferative, analgesic, and anti-coagulant properties. Acyclovir (Zovirax(®)), the first guanidine-derived pharmaceutical for the treatment of herpes infections since late 1970s, was synthesized based on a marine arabinosyl nucleoside, spongosine. Recently, ziconotide (Prialt(®)), a synthetic form of the marine-derived peptide (ω-conotoxin MVIIA) comprising a guanidine moiety, has been approved for the treatment of chronic pain. This review surveys over 130 compounds of guanidine-containing secondary metabolites from marine invertebrates with emphasis on their pharmacological significance and structure-activity relationships.

100 项与 Spongosine 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Spongosine	-	-

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病周围神经性疼痛	临床2期	捷克	Swedish Orphan Biovitrum AB	2007-05-01
糖尿病周围神经性疼痛	临床2期	德国	Swedish Orphan Biovitrum AB	2007-05-01
糖尿病周围神经性疼痛	临床2期	南非	Swedish Orphan Biovitrum AB	2007-05-01
糖尿病性神经病变	临床2期	-	Sobi Analytics Ltd.	-
糖尿病性神经病变	临床2期	-	浙江冠科美博生物科技有限公司	-
炎症性疼痛	临床前	英国	Swedish Orphan Biovitrum AB	-