预约演示
更新于：2026-04-02
Sulodexide
舒洛地特
更新于：2026-04-02
概要
基本信息
原研机构 |
在研机构 |
权益机构- |
最高研发阶段临床3期 |
最高研发阶段(中国)撤市 |
特殊审评- |
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关联
50
项与 舒洛地特 相关的临床试验NCT07465627
Early Vessel Recoil Following Below-the-knee (BTK) Artery Treatment With the Spur Peripheral Retrievable Scaffold System in Specific Patient Populations With Chronic Limb-threatening Ischemia (CLTI) - The DEEPER CHALLENGE Single Center Prospective Study
Chronic limb threatening ischemia (CLTI) represents the most advanced stage of peripheral arterial disease (PAD) and is characterized by ischemic rest pain, non-healing wounds, or ischemic gangrene. High-risk PAD populations including patients with end-stage renal disease and or diabetes also experience worse outcomes with significantly increased rates of amputation and mortality.
Although some patients with PAD are best treated with a combination of medical management, exercise and lifestyle modification, revascularization is indicated in those with advanced stages of disease and particularly in the presence of CLTI. Revascularization of below-the-knee (BTK) arteries is required for most patients suffering from CLTI, but treatment faces numerous challenges comprising calcification, small vessel size, long-lesion length and early elastic recoil. With regard to these challenges, numerous innovative techniques and devices have been developed within the past decades to optimize endovascular treatment of BTK vessels.
The Spur Peripheral Retrievable Scaffold System (Spur) was developed to directly address many of these pitfalls of infrapopliteal arterial disease. The premise of the design of the Spur is to provide temporary mechanical scaffolding and to prepare the vessel for treatment with a drug-coated balloon (DCB) to enhance drug absorption by creating channels in the endothelium by the deployed Spur.
The objective of this study is to perform a prospective, single-center, single-arm, non-randomized study to evaluate acute vessel recoil following BTK treatment with the Spur Retrievable Scaffold System in combination with a commercially available DCB in specific patients populations. Specific patient populations that are selected to participate in this study are either at high risk to discover unfavorable outcomes with standard techniques due to a high complexity of lesions and/or patients that are not adequately mirrored in available studies. The patient cohorts that will be studied are diabetics and patients on hemodialysis (for at least 6 months). As women are commonly under-represented in comparable trials, this study requires at least 50% of women for each cohort.
The primary endpoint is vessel recoil within 15 minutes post treatment assessed with angiography. Secondary endpoints will be followed out to 12 months.
Although some patients with PAD are best treated with a combination of medical management, exercise and lifestyle modification, revascularization is indicated in those with advanced stages of disease and particularly in the presence of CLTI. Revascularization of below-the-knee (BTK) arteries is required for most patients suffering from CLTI, but treatment faces numerous challenges comprising calcification, small vessel size, long-lesion length and early elastic recoil. With regard to these challenges, numerous innovative techniques and devices have been developed within the past decades to optimize endovascular treatment of BTK vessels.
The Spur Peripheral Retrievable Scaffold System (Spur) was developed to directly address many of these pitfalls of infrapopliteal arterial disease. The premise of the design of the Spur is to provide temporary mechanical scaffolding and to prepare the vessel for treatment with a drug-coated balloon (DCB) to enhance drug absorption by creating channels in the endothelium by the deployed Spur.
The objective of this study is to perform a prospective, single-center, single-arm, non-randomized study to evaluate acute vessel recoil following BTK treatment with the Spur Retrievable Scaffold System in combination with a commercially available DCB in specific patients populations. Specific patient populations that are selected to participate in this study are either at high risk to discover unfavorable outcomes with standard techniques due to a high complexity of lesions and/or patients that are not adequately mirrored in available studies. The patient cohorts that will be studied are diabetics and patients on hemodialysis (for at least 6 months). As women are commonly under-represented in comparable trials, this study requires at least 50% of women for each cohort.
The primary endpoint is vessel recoil within 15 minutes post treatment assessed with angiography. Secondary endpoints will be followed out to 12 months.
开始日期2026-03-01 |
申办/合作机构 |
NCT07084727
Retinal Biomarkers as a Tool for Early Detection of Endothelial Dysfunction in Women With Preeclampsia
Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.
开始日期2025-07-01 |
申办/合作机构- |
NCT07038707
Research on the Identification of Early Screening Markers for Herpes Zoster Neuralgia Based on Intestinal Flora Analysis
Herpes zoster (HZ), especially postherpetic neuralgia, is one of the most typical types of clinical neuralgia. The incidence rate of HZ in China is approximately 7.7%. Among them, 29.8% of HZ patients eventually develop PHN. About 20% of PHN patients suffer from severe neuralgia for more than one year, or even ten years. It is worth noting that patients with neuralgia are prone to comorbidities such as depression, anxiety and sleep disorders, which seriously affect their work efficiency and quality of life. This is a great torment to both the patients and their families, and it also imposes a heavy burden on the medical system.
Professor Xiao Lizu, a collaborator of our team, has discovered in clinical practice that spinal cord electrical stimulation for HZ patients can significantly reduce the risk of developing PHN. Other therapies for reducing the risk of PHN include multiple parvertebral injections of local anesthetics/steroids, which require patients to return for repeated visits. Although these intervention measures have good effects, they may bring additional economic burdens to patients, treatment side effects and prolong their hospital stays. Therefore, they are not suitable for all patients. From this perspective, our development of early screening methods and selective non-pharmacological intervention only for high-risk patients will improve the overall treatment status of HZ, effectively reduce the incidence of PHN, and alleviate the burden on medical insurance and the medical system at the same time.
This project aims to conduct the following research by analyzing the intestinal flora of patients: identifying biomarkers with the ability to predict the risk of PHN in patients, constructing a machine learning classifier for risk prediction, and developing an early screening kit based on this.
Furthermore, traditional studies mostly focus on a single pathological link and lack systematic multi-dimensional analysis. In recent years, the cerebral lymphatic system, as a key pathway for the clearance of metabolic wastes in the brain, has attracted widespread attention. Furthermore, the role of the gut-brain axis in pain regulation has gradually been recognized. Therefore, it is of great scientific significance to integrate and explore the pathological mechanism of PHN from three dimensions: the lymphatic system, neuroinflammation, and intestinal flora.
This project assumes that patients with PHN have a pathological triad of "lymphoid dysfunction - neuroinflammatory activation - intestinal flora imbalance". The specific manifestations are as follows: Impaired lymphoid clearance function (decreased DTI-ALPS index and increased free water), activated systemic inflammatory response (elevated TNF-α and IL-6), and disordered intestinal flora structure (decreased α diversity and increased opportunistic pathogenic bacteria). The three interact with each other and have a synergistic effect, jointly participating in the pathogenesis of PHN.The expected outcome of this project may provide new options for pain management of the large group of neuralgia patients, improve their quality of life, and has great practicality and practical value.
Professor Xiao Lizu, a collaborator of our team, has discovered in clinical practice that spinal cord electrical stimulation for HZ patients can significantly reduce the risk of developing PHN. Other therapies for reducing the risk of PHN include multiple parvertebral injections of local anesthetics/steroids, which require patients to return for repeated visits. Although these intervention measures have good effects, they may bring additional economic burdens to patients, treatment side effects and prolong their hospital stays. Therefore, they are not suitable for all patients. From this perspective, our development of early screening methods and selective non-pharmacological intervention only for high-risk patients will improve the overall treatment status of HZ, effectively reduce the incidence of PHN, and alleviate the burden on medical insurance and the medical system at the same time.
This project aims to conduct the following research by analyzing the intestinal flora of patients: identifying biomarkers with the ability to predict the risk of PHN in patients, constructing a machine learning classifier for risk prediction, and developing an early screening kit based on this.
Furthermore, traditional studies mostly focus on a single pathological link and lack systematic multi-dimensional analysis. In recent years, the cerebral lymphatic system, as a key pathway for the clearance of metabolic wastes in the brain, has attracted widespread attention. Furthermore, the role of the gut-brain axis in pain regulation has gradually been recognized. Therefore, it is of great scientific significance to integrate and explore the pathological mechanism of PHN from three dimensions: the lymphatic system, neuroinflammation, and intestinal flora.
This project assumes that patients with PHN have a pathological triad of "lymphoid dysfunction - neuroinflammatory activation - intestinal flora imbalance". The specific manifestations are as follows: Impaired lymphoid clearance function (decreased DTI-ALPS index and increased free water), activated systemic inflammatory response (elevated TNF-α and IL-6), and disordered intestinal flora structure (decreased α diversity and increased opportunistic pathogenic bacteria). The three interact with each other and have a synergistic effect, jointly participating in the pathogenesis of PHN.The expected outcome of this project may provide new options for pain management of the large group of neuralgia patients, improve their quality of life, and has great practicality and practical value.
开始日期2025-07-01 |
申办/合作机构- |
100 项与 舒洛地特 相关的临床结果
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100 项与 舒洛地特 相关的转化医学
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100 项与 舒洛地特 相关的专利（医药）
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312
项与 舒洛地特 相关的文献（医药）2026-01-01·EUROPEAN JOURNAL OF PHARMACOLOGY
Sulodexide can ameliorates renal interstitial fibrosis in adenine-induced kidney injury rats
Article
作者: Li, Wenbin ; Xing, Minghui ; Xu, Huiyan ; Wang, Qun ; Li, Lin ; Zhang, Yifei ; Liang, Liming ; Kong, Xianglei ; Xu, Shuqi
OBJECTIVE:
To investigate the effect and mechanisms of sulodexide(SDX) on adenine-induced kidney injury (KI) in rats.
METHODS:
Thirty female Sprague-Dawley rats were randomized into 3 groups: rats were fed on a normal diet (control group), rats received 0.75 % adenine diet for 4 weeks and 0.9 % saline intraperitoneally for 8 weeks (KI group) and rats received 0.75 % adenine diet for 4 weeks and sulodexide (15 mg/kg/day) intraperitoneally for 8 weeks (KI + SDX group). After the treatments of 8 weeks, the blood and kidney tissue specimens were obtained. Biochemical index and pathological staining were used to assess renal injury and fibrosis. Immunohistochemistry and Western blot were used to detect fibrosis-related proteins and signaling pathways.
RESULTS:
Compared with the control group, the KI group showed higher blood creatinine and urea nitrogen levels, lower total protein levels, and increased renal injury, with significantly higher expression of α-SMA (p < 0.01) and FN (p < 0.01) and increased expression of the Wnt/β-catenin signaling pathway proteins Wnt3a (p < 0.05) and β-catenin (p < 0.01). After sulodexide treatment, biochemical indexes and renal pathological manifestations were improved, and the expression of α-SMA (p < 0.01) and FN (p < 0.01) were significantly reduced, and the expression of Wnt/β-catenin signaling pathway proteins Wnt3a (p < 0.01) and β-catenin (p < 0.05) was decreased.
CONCLUSIONS:
The study demonstrated that SDX can delay renal interstitial fibrosis in adenine-induced kidney injury rats, which may be related to the inhibition of Wnt/β-catenin signaling pathway.
2025-12-19·Khirurgiia
Pharmacological support strategies following endovenous laser ablation in patients with varicose veins
Article
作者: Kamaev, A.A. ; Pshennikov, A.S. ; Suchkov, I.A. ; Kalinin, R.E.
Objective. To evaluate the impact of endovenous laser ablation (EVLA) combined with micronized purified flavonoid fraction (MPFF), sulodexide, and their combination on the dynamics of circulating biomarkers and quality of life in patients with varicose vein disease of the lower extremities. Material and methods. A prospective study included 173 patients who underwent EVLA. They were allocated into four groups: EVLA alone (n=44), EVLA+MPFF (n=43), EVLA+sulodexide (n=43), and EVLA+MPFF+sulodexide (n=43). MPFF was prescribed at 1000 mg/day and sulodexide at 500 LSU/day for two months. Serum levels of E-selectin, MCP-1, VEGF, MMP-2, and MMP-9 were measured using ELISA at baseline (V0), after 2 months (V2), and after 12 months (V3). Quality of life was assessed with validated questionnaires CIVIQ-20 and SF-36. Results. EVLA alone provided early improvements in quality of life and reductions in E-selectin and MCP-1, although the effect partially diminished by 12 months in patients with advanced disease. MPFF mainly reduced MCP-1 (213.8 → 115.5 pg/mL; p<0.001) and VEGF (109.6 → 52.6 pg/mL; p<0.001), particularly in patients with CEAP C2–C3. Sulodexide significantly decreased MMP-2 (517.8 → 250.8 ng/mL; p<0.001) and MMP-9 (19.4 → 9.9 ng/mL; p<0.001) in CEAP C4–C6, although the effect partly attenuated at 12 months. The most pronounced and sustained effect was observed in the combination group: E-selectin (60.1 → 43.1 ng/mL), MCP-1 (265.4 → 131.3 pg/mL), VEGF (188.7 → 87.1 pg/mL), MMP-2 (487.8 → 230.1 ng/mL), and MMP-9 (19.8 → 8.7 ng/mL) all significantly decreased (all p<0.001), while improvements in CIVIQ-20 and SF-36 were maintained throughout one year. Conclusion. EVLA provides clinical improvement and reductions in inflammatory biomarkers, but the effect is less durable in advanced disease. MPFF primarily modulates MCP-1 and VEGF, while sulodexide acts on MMP-2 and MMP-9. Their combination shows complementary pathogenetic mechanisms, yielding the most durable biochemical and clinical benefits, and may represent the optimal pharmacological support for EVLA in patients with severe chronic venous disease.
2025-10-01·JOURNAL OF CLINICAL LABORATORY ANALYSIS
Clinicopathological Characteristics and Prognosis of
IgA
Nephropathy Combined With Malignant Hypertension Kidney Injury
Article
作者: Yang, Wenzhuo ; Dai, Zefang ; Li, Zhijian ; Li, Jianbo ; Zhong, Zhong
ABSTRACT:
Background:
IgA nephropathy (IgAN), a major cause of primary glomerulonephritis, is closely associated with malignant hypertension (MHT). This study aimed to explore the clinicopathological characteristics and renal prognosis of patients with IgAN combined with malignant hypertension kidney injury (IgAN‐MHT) and investigate the associations of clinicopathological indicators with prognosis.
Methods:
In this single‐center retrospective cohort study, patients diagnosed with IgAN‐MHT through kidney biopsy between January 1, 2008, and June 30, 2023, in our hospital were enrolled. Cox regression models were used to assess the associations between clinical indicators and renal prognosis in IgAN‐MHT patients.
Results:
A total of 70 patients were included in the analysis of renal function improvement. During a median follow‐up time of 9.4 months, 26 patients (37.1%) achieved renal function improvement. Patients in the improved renal function group had higher hemoglobin levels (
p
= 0.003), lower serum creatinine levels (
p
= 0.006), a higher proportion of patients using sulodexide (
p
= 0.018), and a lower proportion of glomerulosclerosis (
p
< 0.001). Multivariable Cox regression analysis indicated that a higher proportion of glomerulosclerosis was independently associated with a lower likelihood of renal function improvement (HR = 0.97, 95% CI = 0.96–0.99,
p
= 0.003), while sulodexide administration was independently associated with a higher likelihood of improvement (HR = 2.75, 95% CI = 1.18–6.41,
p
= 0.019).
Conclusion:
This study revealed that in IgAN‐MHT patients, a higher proportion of glomerulosclerosis was independently associated with poorer renal outcomes, while the use of sulodexide showed a significant independent association with improved renal function.
160
项与 舒洛地特 相关的新闻（医药）2026-03-31
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截至03月31日15点59分，近期共有 497 本期刊发布了 1131 篇文章，其中糖尿病相关的文章共 339 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 EHJ-QCCO IF: 04.600 GLP-1受体激动剂与减重手术在患有肥厚型心肌病的肥胖患者中的结局比较：一项多中心倾向匹配分析
Mahmoud, Ahmed K, Awad, Kamal, Sheashaa, Hesham, Kandil, Omneya, Farina, Juan M, Ibrahim, Ramzi, etc.
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。
研究纳入5002例符合条件的患者，经1:1倾向匹配后每组955例，平均年龄54±13岁，70%为女性，基线体重指数（BMI）均为40.0 kg/m²。
研究将患者分为两组，一组为从未接受过减重手术的GLP-1 RA使用者，另一组为从未使用过GLP-1 RA的减重手术患者，通过倾向匹配平衡人口统计学特征、合并症及用药情况。随访24个月，评估全因死亡率、急性心力衰竭（HF）住院、心律失常、BMI变化及心血管症状等指标。
结果显示，与减重手术相比，GLP-1 RA治疗在全因死亡率和心力衰竭事件方面表现更优。具体数据显示，GLP-1 RA组全因死亡率为2.0%，显著低于BS组的4.4%（HR=0.46，95%CI 0.27-0.80，P=0.004）；HF住院率GLP-1 RA组为8.7%，低于BS组的14.0%（HR=0.60，95%CI 0.46-0.79，P<0.001）。此外，GLP-1 RA组复合心血管结局发生率（10.7%）显著低于BS组（17.2%）（HR=0.60，95%CI 0.47-0.77，P<0.001）。
BMI变化方面，BS组平均降低4.0 kg/m²，高于GLP-1 RA组的2.6 kg/m²（P<0.001）。但两组在心律失常和心血管症状发生率上无显著差异。
研究结论指出，在患有肥厚型心肌病的肥胖患者中，GLP-1 RA治疗与减重手术相比，全因死亡率和心力衰竭事件风险更低。未来研究需进一步验证这一发现。
本文由 韩玉莲 编辑
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EHJ-QCCO | Ahead of Print.
10.1093/ehjqcco/qcag051
02 Frontiers in immunology IF: 05.900 早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据
Liu, Peiyan, Yao, Guixiang, Wu, Yixia, Zhou, Qi, etc.
近日，一项发表于Frontiers in Immunology的研究通过对美国国家健康与营养检查调查（NHANES）2005-2018年数据的二次分析及小鼠实验，揭示了咖啡摄入时间对胰岛素抵抗的关键影响。
研究发现，早晨集中摄入咖啡（如上午4:00-11:59 AM）与胰岛素抵抗（通过甘油三酯-葡萄糖指数（TyG）、代谢性胰岛素抵抗指数（METS-IR）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）三个指标验证）呈线性负相关，而全天分散摄入咖啡则呈J形关联。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。
本文由 韩玉莲 编辑
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Frontiers in immunology | Volume 17, Issue
10.3389/fimmu.2026.1775412
03 EJPC IF: 07.500 2型糖尿病成人对有氧运动训练的最大摄氧量峰值（VO2peak）反应性决定因素：PROTECTION研究
Michielsen, Matthijs, Gojevic, Tin, Bekhuis, Youri, Claes, Jomme, Machado, Felipe, Claessen, Guido, etc.
European Journal of Preventive Cardiology在线发表的PROTECTION研究表明，26周中等强度骑行计划可显著改善2型糖尿病（T2D）成人的心肺功能（最大摄氧量峰值VO2peak），但个体反应差异显著，脂肪质量和胰岛素抵抗是关键预测因素。
该研究纳入108例T2D成人参与26周监督下的中等强度骑行训练（3次/周），最终88例完成全程（平均年龄59.8±9.2岁，64%为男性）。结果显示，VO2peak平均提升3.6±2.5 mL/kg/min（增幅17%）。分组分析发现，与无反应者相比，高反应者的脂肪质量更低、胰岛素抵抗更小，且基线体能（心肺功能）也较低。
研究通过单变量和多变量LASSO回归分析，识别出影响VO2peak变化的关键因素：女性性别、吸烟、人体测量指标（如体重/体脂）、胰岛素抵抗及β受体阻滞剂或GLP-1受体激动剂的使用与VO2peak改善负相关；而肺功能、肌肉力量和血红蛋白水平与之正相关。多变量模型进一步证实，脂肪质量（%）和胰岛素抵抗是决定VO2peak反应性的核心基线因素。
研究结论指出，26周中等强度骑行能有效提升T2D成人的心肺功能，但个体反应差异较大。建议在糖尿病（前期）诊断后尽早开展运动干预，并结合改善身体成分的措施，以增强心肺功能的提升效果。
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EJPC | Ahead of Print.
10.1093/eurjpc/zwag150
04 Diabetes, obesity & metabolism IF: 05.700 司美格鲁肽1.7 mg用于青少年肥胖治疗的有效性、安全性和药代动力学：基于模型的药物开发方法
Strathe, Anders, Bomberg, Eric M, Jensch, Garrit, Kildegaard, Jonas, Harder-Lauridsen, Nina M, Weghuber, Daniel, etc.
本研究采用基于模型的药物开发方法（MIDD），结合青少年STEP TEENS 3期研究（N=201）和成人STEP研究（约3100名参与者）数据，分析1.7 mg司美格鲁肽在青少年肥胖治疗中的有效性、安全性和药代动力学特征。研究目的是探索青少年肥胖治疗的低剂量选择，评估1.7 mg剂量与成人及2.4 mg剂量的比较效果。
方法上，研究整合了不同剂量（0.25-2.4 mg）的浓度-时间曲线模型，通过模拟分析青少年与成人的药代动力学（PK）参数差异，同时计算BMI变化百分比，估算达成≥5%、≥10%、≥15% BMI降低的比例，并根据暴露量预测胃肠道不良事件（AE）发生率。主要协变量分析显示体重是影响司美格鲁肽暴露量的关键因素。
结果显示，青少年与成人在68周内的司美格鲁肽浓度模拟值相似，表明青少年无需调整剂量即可维持稳定暴露水平。1.7 mg剂量组青少年的平均BMI变化为-15.2%，与2.4mg剂量组（-17.4%）相当，且显著优于安慰剂（P<0.01）。预设BMI降低阈值（≥5%、≥10%、≥15%）的达成比例在青少年、成人及不同剂量组间均无显著差异，胃肠道不良事件发生率也与剂量和人群特征无关。
该研究证实，药代动力学/药效学（PK/PD）和安全性模型证实1.7 mg司美格鲁肽在青少年中具有与成人及2.4m g剂量相当的暴露量、耐受性及BMI降低效果，这些结果支持2024年11月Wegovy标签批准1.7 mg剂量用于≥12岁青少年肥胖治疗，无需额外开展青少年1.7 mg安慰剂对照试验。
本文由 韩玉莲 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70678
中国发表（86）
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Frontiers in immunology IF: 05.900Volume 17, Issue No.56Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems胸腺瘤相关GAD65自身免疫：一种涉及神经、内分泌和肾脏系统多器官损伤的统一机制DOI: 10.3389/fimmu.2026.1790631
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Drug Des Devel Ther IF: 05.100Volume 20, Issue No.58A Comprehensive Review on the Cardioprotective and Nephroprotective Effects of Semaglutide, and Its Therapeutic Efficacy and Mechanisms in Cardiorenal Syndrome司美格鲁肽在心肾综合征中的应用：有效性、机制及临床证据综合综述DOI: 10.2147/DDDT.S581491
Drug Des Devel Ther IF: 05.100Volume 20, Issue No.59Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)胰高血糖素样肽-1受体激动剂（GLP-1RAs）与心脏心律失常：作用机制与治疗潜力DOI: 10.2147/DDDT.S579419
Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation知母-黄柏对2型糖尿病的作用：通过线粒体功能多靶点调节的分子机制DOI: 10.3389/fcell.2026.1763178
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Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.62Association Between Thyroid Hormone Sensitivity and Peripheral Arterial Disease in Euthyroid Patients with Type 2 Diabetes甲状腺功能正常的2型糖尿病患者中甲状腺激素敏感性与外周动脉疾病的关系DOI: 10.2147/DMSO.S571291
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study甲状腺功能正常的2型糖尿病患者中甲状腺激素指标与糖尿病肾病组织病理学严重程度的关系：一项基于活检的横断面研究DOI: 10.2147/DMSO.S589576
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.64Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease非酒精性脂肪肝患者中甲状腺激素水平与2型糖尿病的关系：聚焦游离三碘甲状腺原氨酸与游离甲状腺素比值DOI: 10.2147/DMSO.S577491
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Emulating the LEADER trial in China: a regulatory science case study on non-interventional research在中国模拟LEADER试验：一项关于非干预性研究的监管科学案例研究DOI: 10.3389/fendo.2026.1777954
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data超越甘油三酯-葡萄糖指数，胆固醇-高密度脂蛋白-葡萄糖指数作为主要不良心血管事件患者糖尿病风险的更优预测指标：来自CHARLS数据库和真实世界数据的双重证据DOI: 10.3389/fendo.2026.1797342
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study妊娠期糖尿病（GDM）复发史与后续妊娠高血压疾病风险独立相关：一项大型回顾性队列研究DOI: 10.3389/fendo.2026.1736779
Frontiers in immunology IF: 05.900Volume 17, Issue No.68Timing of coffee consumption and insulin resistance: evidence from human and animal studies早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据DOI: 10.3389/fimmu.2026.1775412
FCVM IF: 02.900Volume 13, Issue No.69From lipid dysbalance to cardiorenal decompensation: apoB/ApoA1 ratio is associated with acute cardiorenal injury in CAD patients载脂蛋白B/载脂蛋白A1比值与冠心病患者1型心肾综合征的关联DOI: 10.3389/fcvm.2026.1754713
Frontiers in oncology IF: 03.300Volume 16, Issue No.70The correlation between the triglyceride-glucose index and the odds of cervical cancer甘油三酯-葡萄糖指数与宫颈癌风险的关联研究DOI: 10.3389/fonc.2026.1766167
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.71Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study甘油三酯-葡萄糖系统性炎症指数(TyG-SII)与创伤性骨折患者术前深静脉血栓形成的单中心回顾性研究DOI: 10.3389/fendo.2026.1700809
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.72Metformin Induces Ferroptosis and Inhibits Malignant Progression in Diabetic Breast Cancer二甲双胍诱导铁死亡并抑制糖尿病乳腺癌的恶性进展DOI: 10.1007/s12010-026-05648-3
Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.73BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial CellsBHMT通过降低同型半胱氨酸并抵消晶状体上皮细胞中的内质网应激来预防糖尿病性白内障DOI: 10.1007/s12010-026-05678-x
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.74Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort多基因和多社会风险评分在2型糖尿病后痴呆中的应用：英国生物样本库队列中的风险分层与预测建模DOI: 10.1177/13872877261435200
Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.75Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges血红蛋白浓度与母婴结局：确定最佳血红蛋白范围DOI: 10.1111/ppe.70142
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.76Liver-pancreas communication in disease and drug development代谢性疾病中的肝脏-胰腺轴：从机制到治疗DOI: 10.1016/j.apsb.2026.01.018
Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.77Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification整合中医药与间歇性禁食：治疗糖尿病血管钙化的有前景方法DOI: 10.1016/j.apsb.2026.01.004
Frontiers in immunology IF: 05.900Volume 17, Issue No.78Transcending risk factors: the implications of redefining diabetes as an immunometabolic disease for infectious disease studies超越风险因素：将糖尿病重新定义为免疫代谢疾病对传染病研究的意义DOI: 10.3389/fimmu.2026.1794628
Bioactive materials IF: 20.300Volume 62, Issue No.79Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair智能响应水凝胶协同介导免疫重塑-抗菌-血管生成级联反应用于糖尿病足溃疡修复DOI: 10.1016/j.bioactmat.2026.03.034
Kidney diseases IF: 03.100Volume 12, Issue 1No.80Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis非奈利酮用于合并2型糖尿病的慢性肾脏病中国患者：FIDELITY亚组分析DOI: 10.1159/000550850
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.81Exercise-derived exosomes mediate crosstalk between skeletal muscle, adipose tissue, and bone: mechanisms of inter-organ communication and tissue adaptation运动来源外泌体介导骨骼肌、脂肪组织与骨间串扰：器官间通讯及组织适应机制DOI: 10.1080/10408398.2026.2646268
Journal of proteome research IF: 03.600Ahead of Print.No.82Proteome Profiling Reveals Inflammation and Fibrosis Biomarkers in Urinary Migrasomes of Patients with Diabetic Kidney Disease蛋白质组分析揭示糖尿病肾病患者尿迁移小体中的炎症和纤维化生物标志物DOI: 10.1021/acs.jproteome.5c01073
Journal of diabetes IF: 03.700Volume 18, Issue 4No.83Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy富氢透明质酸敷料通过促进线粒体自噬改善糖尿病足溃疡DOI: 10.1111/1753-0407.70209
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Acta radiologica IF: 01.100Ahead of Print.No.86Association of coronary computed tomography angiography-derived plaque characteristics and brain white matter hyperintensity: an observational study冠状动脉计算机断层血管造影衍生斑块特征与脑白质高信号的关联：一项观察性研究DOI: 10.1177/02841851261421597
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Vitamins and hormonesVolume 131, Issue No.52Growth hormone: Synthesis and regulation生长激素：合成与调节DOI: 10.1016/bs.vh.2025.10.001
Annales d'endocrinologie IF: 02.900Ahead of Print.No.53Facts and news about growth hormone replacement therapy in adults成人生长激素替代治疗的事实与新闻DOI: 10.1016/j.ando.2026.102547
Vitamins and hormonesVolume 131, Issue No.54Acromegaly-Physiopathology and etiology肢端肥大症-病理生理学和病因学DOI: 10.1016/bs.vh.2026.01.001
Vitamins and hormonesVolume 131, Issue No.55Acromegaly and genetics肢端肥大症与遗传学DOI: 10.1016/bs.vh.2025.10.008
CMAJ IF: 11.300Volume 198, Issue 12No.56Management of brain-heart multimorbidity: a clinical practice guideline脑心共病的管理：临床实践指南DOI: 10.1503/cmaj.251137
RheumatologyAhead of Print.No.57Cardioprotective mechanisms and effects of glucagon-like peptide-1 receptor agonists in autoimmune rheumatic diseases胰高血糖素样肽-1受体激动剂在自身免疫性风湿病中的心脏保护机制及作用DOI: 10.1093/rheumatology/keag147
Am J Physiol Cell Physiol IF: 04.700Volume 330, Issue 4No.58Vagal GABAergic signaling in autonomic control of cardiometabolic function迷走神经GABA能信号在心脏代谢功能自主控制中的作用DOI: 10.1152/ajpcell.00790.2025
JMIR diabetes IF: 02.600Volume 11, Issue No.59Exploring the Needs of Health Professionals for a Type 2 Diabetes Remote Patient Monitoring Dashboard for Personalized Care: Focus Group Study探索医疗专业人员对个性化护理用2型糖尿病远程患者监测仪表板的需求：焦点小组研究DOI: 10.2196/84894
Advances in physiology education IF: 01.700Ahead of Print.No.60Exploring physiology's past to inspire learning: an engaging undergraduate experience at the University of La Réunion探索生理学的历史以激发学习：留尼汪大学的沉浸式本科学习体验DOI: 10.1152/advan.00255.2025
Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.61Overweight and Obesity are Associated with Lower Renal Blood Flow in Autosomal Dominant Polycystic Kidney Disease超重和肥胖与常染色体显性多囊肾病患者的肾血流量降低相关DOI: 10.1159/000550949
Annals of Internal Medicine IF: 15.200Ahead of Print.No.62Summary for Patients: Fluvoxamine and Metformin for Fatigue in Patients With Long COVID新冠长期患者疲劳症状治疗的氟伏沙明与二甲双胍患者摘要DOI: 10.7326/ANNALS-25-03959-PS
Annals of Internal Medicine IF: 15.200Ahead of Print.No.63The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial氟伏沙明和二甲双胍对长新冠患者疲劳的作用：一项适应性随机试验DOI: 10.7326/ANNALS-25-03959
Annals of Internal Medicine IF: 15.200Ahead of Print.No.64Patient-Reported Outcomes in People With Type 2 Diabetes Escalating Dulaglutide or Switching From Dulaglutide to Tirzepatide2型糖尿病患者度拉糖肽升级或切换至替尔泊肽时的患者报告结局DOI: 10.7326/ANNALS-25-03219
Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.65Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system秀丽隐杆线虫中脂肪酸对摄食的调节揭示了类似GLP-1的多激动剂信号系统的潜在祖先起源DOI: 10.1073/pnas.2530979123
Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.66Regulation of STK38 by autophagy governs YAP1 activity during paligenosis自噬对STK38的调控在再生过程中控制YAP1活性DOI: 10.1073/pnas.2517488123
Diabetes IF: 07.500Ahead of Print.No.67LEAP2 Reduces Ad Libitum Food Intake and Attenuates Postprandial Glucose Excursions in Men With ObesityLEAP2减少肥胖男性的自由摄食并减轻餐后血糖波动DOI: 10.2337/db25-1132
Circulation IF: 38.600Volume 153, Issue 13No.68Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study"Hundemer和Vaidya对文章《亚临床原发性醛固酮增多症与主要不良心血管事件：一项基于人群的纵向队列研究》的回复DOI: 10.1161/CIRCULATIONAHA.125.079057
Diabetes care IF: 16.600Ahead of Print.No.69Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring连续血糖监测中缺失数据和监测时长对下游分析的影响DOI: 10.2337/dc25-2935
PloS one IF: 02.600Volume 21, Issue 3No.70Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol测试血流限制训练在增强2型糖尿病患者运动健康益处方面的可行性（BOOST-HEALTH试验）：研究方案DOI: 10.1371/journal.pone.0346176
PloS one IF: 02.600Volume 21, Issue 3No.71Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study韩国成年人降压药物不依从的心理社会预测因素：一项全国性横断面研究DOI: 10.1371/journal.pone.0345509
Diabetes care IF: 16.600Ahead of Print.No.72Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test囊性纤维化中使用非空腹50克1小时口服葡萄糖耐量试验筛查糖尿病和前驱糖尿病DOI: 10.2337/dc25-2806
PloS one IF: 02.600Volume 21, Issue 3No.73Temporal-spatial trends in childbirth in Ontario, Canada加拿大安大略省分娩的时空趋势DOI: 10.1371/journal.pone.0342215
PloS one IF: 02.600Volume 21, Issue 3No.74Editorial Note: Machine learning-driven Diabetes Health Tracer (DHT): Optimizing prognosis using RaSK_GraDe and RaSK_GraDeL models社论注记：机器学习驱动的糖尿病健康追踪器（DHT）：使用RaSK_GraDe和RaSK_GraDeL模型优化预后DOI: 10.1371/journal.pone.0346001
PloS one IF: 02.600Volume 21, Issue 3No.75The effect of game-based education on adherence to treatment and anxiety level in type 2 diabetics started on insulin therapy游戏化教育对开始胰岛素治疗的2型糖尿病患者的治疗依从性和焦虑水平的影响DOI: 10.1371/journal.pone.0345292
Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.76T1D GRS: a tool for identifying children and adolescents with monogenic diabetesT1D GRS：一种用于识别儿童和青少年单基因糖尿病的工具DOI: 10.1159/000551615
Age and ageing IF: 07.100Volume 55, Issue 3No.77Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials非药物和药物干预措施在预防老年人谵妄中的有效性：一项随机对照试验的系统综述和荟萃分析DOI: 10.1093/ageing/afag068
Frontiers in physiology IF: 03.400Volume 17, Issue No.78MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress甲硫氨酸亚砜还原酶B2（MsrB2）缺陷在高血压应激下放大细胞外基质驱动的心脏纤维化DOI: 10.3389/fphys.2026.1772933
Gut microbes reportsVolume 3, Issue 1No.79Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults肥胖与肠道菌群作为老年人群认知衰退的关键驱动因素：系统综述与荟萃分析DOI: 10.1080/29933935.2025.2605879
iScience IF: 04.100Volume 29, Issue 4No.80Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration累积的mtDNA突变与NADH相关呼吸的特定损伤相关联DOI: 10.1016/j.isci.2026.115184
iScience IF: 04.100Volume 29, Issue 4No.81A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss脂肪库特异性瘦素基因表达调控的新机制及其减重后的持续性DOI: 10.1016/j.isci.2026.115101
Frontiers in medicine IF: 03.000Volume 13, Issue No.82Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts英国生物样本库衍生多基因风险评分在巴西队列中的有限可转移性DOI: 10.3389/fmed.2026.1771205
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.83Six-year Follow-Up of Nonpharmacological and Nonsurgical Obesity Treatments非药物和非手术肥胖治疗的六年随访DOI: 10.2147/DMSO.S590255
JCEM case reportsVolume 4, Issue 4No.84Unanticipated remission of primary hyperparathyroidism following cinacalcet西那卡塞治疗后原发性甲状旁腺功能亢进症的意外缓解DOI: 10.1210/jcemcr/luag014
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.85Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania连续性葡萄糖监测、1型糖尿病患者的糖尿病困扰及幸福感：来自立陶宛全国性调查的结果DOI: 10.3389/fcdhc.2026.1708124
Preventive medicine reports IF: 02.400Volume 65, Issue No.86Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan密歇根州基于人群的纵向研究中，长期新冠与新发心血管代谢及呼吸系统疾病关联的性别差异DOI: 10.1016/j.pmedr.2026.103449
J Clin Exp Hepatol IF: 03.200Volume 16, Issue 3No.87The Association Between Genetic Polymorphism in the Receptor for Advanced Glycation End-Products and Metabolic Dysfunction-Associated Steatotic Liver Disease晚期糖基化终产物受体基因多态性与代谢功能障碍相关脂肪性肝病的关联DOI: 10.1016/j.jceh.2026.103530
Kidney medicine IF: 03.400Volume 8, Issue 4No.88Primary Care Use and Clinical Outcomes in a Prevalent Cohort of Patients Receiving Hemodialysis接受中心性血液透析的医疗保险受益人中初级医疗服务使用情况及临床结局DOI: 10.1016/j.xkme.2026.101278
In silico pharmacologyVolume 14, Issue 1No.89NMR-guided metabolomic evaluation of Aegle marmelos (L.) Correa: unveiling antihypertensive, antidiabetic, and anti-inflammatory activitiesNMR引导的木苹果代谢组学评估：揭示其抗高血压、抗糖尿病及抗炎活性DOI: 10.1007/s40203-026-00609-4
Bioinformation IF: 01.900Volume 21, Issue 12No.90Maternal obesity and its impact on pregnancy孕妇肥胖及其对妊娠的影响DOI: 10.6026/973206300214648
Bioinformation IF: 01.900Volume 21, Issue 12No.91Oral lesions in patients with systemic diseases: A hospital-based observational study系统性疾病患者的口腔病变：一项基于医院的观察性研究DOI: 10.6026/973206300214359
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.92Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOSPum1_0014环状RNA、miRNA-146a和miRNA-141-3p作为多囊卵巢综合征生物标志物的评估DOI: 10.1016/j.jtumed.2026.03.002
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa撒哈拉以南非洲地区儿童代谢相关脂肪性肝病：范围综述DOI: 10.3389/fendo.2026.1784970
Int J Nanomedicine IF: 06.500Volume 21, Issue No.94Chitosan-Microcapsulated Insulin Alleviates Mesenteric Microcirculation Dysfunction via Modulating COX-2 and VCAM-1 Expression in Rats with Diabetes Mellitus [Retraction]壳聚糖微囊化胰岛素通过调节糖尿病大鼠COX-2和VCAM-1表达改善肠系膜微循环功能障碍 [撤稿]DOI: 10.2147/IJN.S599834
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.95Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy奈玛特韦/利托那韦诱导的钙通道阻滞剂中毒经大剂量胰岛素治疗成功DOI: 10.6515/ACS.202603_42(2).20251213B
Br J Community NursVolume 31, Issue 4No.96Management of diabetes when comorbid with dementia痴呆合并糖尿病的管理DOI: 10.12968/bjcn.2026.0042
Curēus IF: 01.300Volume 18, Issue 2No.97Differentiated and Poorly Differentiated Thyroid Carcinoma in Ovarian Teratoma With Primary Papillary Thyroid Carcinoma: A Series of Two Case Reports卵巢畸胎瘤中合并原发性乳头状甲状腺癌的分化型和未分化型甲状腺癌：两例病例报告DOI: 10.7759/cureus.104169
Curēus IF: 01.300Volume 18, Issue 2No.98Exercise Intervention for Blood Pressure Reduction in Diabetic Patients: A Systematic Review and Meta-Analysis糖尿病患者的血压降低运动干预：一项系统综述和荟萃分析DOI: 10.7759/cureus.104244
Curēus IF: 01.300Volume 18, Issue 2No.99Clinico-Microbiological Profile of Carbapenem-Resistant Acinetobacter baumannii Isolates From Intensive Care Unit Patients and In Vitro Activity of Sulbactam-Durlobactam: A Cross-Sectional Study From Eastern India印度东部三级医院重症监护病房中碳青霉烯耐药鲍曼不动杆菌的临床及抗菌药物敏感性分析DOI: 10.7759/cureus.104172
Curēus IF: 01.300Volume 18, Issue 2No.100Intramedullary Spinal Cord Abscess With Brain Abscess Secondary to Empyema: A Report of a Rare Case继发于脓胸的髓内脊髓脓肿合并脑脓肿：一例罕见病例报告DOI: 10.7759/cureus.104151
Curēus IF: 01.300Volume 18, Issue 2No.101Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index评估死亡率预测：比较Fournier坏疽严重度指数与Uludag指数的有效性DOI: 10.7759/cureus.104290
Curēus IF: 01.300Volume 18, Issue 2No.102Emphysematous Gastritis With Portal and Mesenteric Venous Gas Complicated by Septic Shock and Ileus: A Case Report伴有门静脉和肠系膜静脉气体的气肿性胃炎，表现为严重休克和肠梗阻：一例报告及文献综述DOI: 10.7759/cureus.104164
Frontiers in nutrition IF: 05.100Volume 13, Issue No.103Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study膝关节骨关节炎患者食用植物性饮食的障碍与促进因素：一项定性研究DOI: 10.3389/fnut.2026.1743219
J Public Health ResVolume 15, Issue 1No.104In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study埃塞俄比亚东部哈拉里市公立医院成人缺血性卒中患者的死亡率及其预测因素：一项回顾性队列研究DOI: 10.1177/22799036261433150
Kidney medicine IF: 03.400Volume 8, Issue 4No.105Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate Based on Creatinine or Cystatin C: Adjust Model Development With More Than 300,000 UK Biobank Participants慢性肾脏病流行病学协作组（CKD-EPI）基于肌酐、胱抑素C及两者结合估算肾小球滤过率（eGFR）：英国生物样本库中的差异分析与预测价值DOI: 10.1016/j.xkme.2026.101288
Infection and drug resistance IF: 02.900Volume 19, Issue No.106Management of Diabetic Foot Infections Using Phage Therapy噬菌体疗法在糖尿病足感染中的综合综述DOI: 10.2147/IDR.S577526
Curēus IF: 01.300Volume 18, Issue 2No.107Unprovoked Deep Vein Thrombosis as a Manifestation of Cushing's Disease自发性深静脉血栓形成作为库欣病的一种表现DOI: 10.7759/cureus.104148
Farmaceuticos comunitarios IF: 00.500Volume 18, Issue 2No.108Mystery Shopper: Antibiotics for sale at flea markets in a Mexican urban area神秘购物者：墨西哥城市地区跳蚤市场中抗生素的销售情况DOI: 10.33620/FC.2173-9218.2026.16
Bioinformation IF: 01.900Volume 21, Issue 12No.109Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study射血分数保留的心力衰竭患者结局中的性别差异：一项回顾性队列研究DOI: 10.6026/973206300214355
Safety and health at work IF: 02.900Volume 17, Issue 1No.110Do the Long-Term Cardiometabolic Effects of Night Shift Work Differ Between Men and Women? A 17-Year Cohort Study of the U.S. Workforce夜班工作对男女心代谢健康的长期影响是否存在差异？一项针对美国劳动力的17年队列研究DOI: 10.1016/j.shaw.2025.11.001
FCVM IF: 02.900Volume 13, Issue No.111Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome结合门诊和家庭有氧运动项目及远程可穿戴设备监测改善代谢综合征患者的焦虑和抑郁症状DOI: 10.3389/fcvm.2026.1798233
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.112Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools磷酸肌醇3-激酶异构体选择性及定量构效关系（QSAR）在糖尿病视网膜病变药物设计中的研究DOI: 10.3389/fphar.2026.1744181
Int Med Case Rep J IF: 00.600Volume 19, Issue No.113Bilateral Superior Branch Retinal Artery Occlusions in a Patient on Pembrolizumab使用帕博利珠单抗治疗的患者出现双眼分支视网膜动脉闭塞DOI: 10.2147/IMCRJ.S584574
Frontiers in medicine IF: 03.000Volume 13, Issue No.114Diabetic retinopathy severity detection using an improved Whale optimization algorithm and convolutional Kolmogorov-Arnold network使用改进鲸鱼优化算法和卷积Kolmogorov-Arnold网络的糖尿病视网膜病变严重程度检测DOI: 10.3389/fmed.2026.1709872
Preventive medicine reports IF: 02.400Volume 65, Issue No.115Nationwide trends and geographic variations of diabetes in pregnancy in Thailand: Epidemiology, neonatal outcomes, and healthcare costs under the universal health coverage scheme (2013-2023)泰国妊娠期糖尿病全国趋势与地理变异：全民医保计划下的流行病学、新生儿结局及医疗费用（2013-2023）DOI: 10.1016/j.pmedr.2026.103452
J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.116The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction人工智能在妊娠糖尿病管理中的变革性作用：筛查、管理及长期预后预测的进展DOI: 10.1007/s40200-025-01817-z
Bioinformation IF: 01.900Volume 21, Issue 12No.117Prevalence of gestational diabetes using IADPSG criteria in North India: A cross-sectional study北印度地区应用IADPSG标准的妊娠糖尿病患病率：一项横断面研究DOI: 10.6026/973206300214876
Bioinformation IF: 01.900Volume 21, Issue 12No.118Impact of thyroid autoantibodies on pregnancy: A prospective cohort study甲状腺自身抗体对妊娠的影响：一项前瞻性队列研究DOI: 10.6026/973206300214749
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.119Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous WomenG4PD指数：机器学习推导的经产妇女糖尿病前期和2型糖尿病风险评分DOI: 10.2147/DMSO.S590000
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.120Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes糖尿病前期在急性冠脉综合征中的作用：被忽视的不良结局预测因子DOI: 10.3389/fcdhc.2026.1745724
Glob Cardiol Sci PractVolume 2025, Issue 2No.121Evaluation of electrocardiographic alterations before and after bariatric surgery重度肥胖患者减重手术前后的心电图变化DOI: 10.21542/gcsp.2025.22
J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.122Operative time and outcome after carotid endarterectomy for symptomatic and asymptomatic carotid stenosis: a retrospective multicenter cohort study有症状和无症状颈动脉狭窄患者颈动脉内膜切除术的手术时间与结局：一项回顾性多中心队列研究DOI: 10.23736/S0021-9509.26.13541-1
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.123Association between vitamin D deficiency and metabolic syndrome among adults in Arab countries阿拉伯国家成年人维生素D缺乏与代谢综合征的关联DOI: 10.26719/2026.32.3.156
Gut microbes reportsVolume 2, Issue 1No.124Gut microbial metabolites as a convergence point between autoimmunity and solid tumors肠道微生物群在连接自身免疫性疾病与癌症中的作用DOI: 10.1080/29933935.2025.2470805
Curēus IF: 01.300Volume 18, Issue 2No.125Association of Gastrointestinal Symptoms and Psychological Issues With the Intake of Fruits, Vegetables, and Junk Food in School Children: A Community-Based Study From Melmaruvathur, Tamil Nadu, India印度泰米尔纳德邦学童中显著的胃肠道症状、心理问题及异常营养状况：一项基于社区的研究DOI: 10.7759/cureus.104262
Curēus IF: 01.300Volume 18, Issue 2No.126Racial and Gender Disparities in the Occurrence and Outcomes of Alcohol-Associated Hepatitis in Hospitalized Patients With Prior Bariatric Surgery减重手术后酒精性肝炎的结局：基于全国住院患者样本的分析DOI: 10.7759/cureus.104251
Curēus IF: 01.300Volume 18, Issue 2No.127Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates皮肤仅闭合术与波哥大袋闭合术：完整筋膜近似率的对比研究DOI: 10.7759/cureus.104203
Curēus IF: 01.300Volume 18, Issue 2No.128Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates阿联酋肛门直肠疾病回顾性分析：人口统计学特征、临床表现与管理策略DOI: 10.7759/cureus.104155
JCEM case reportsVolume 4, Issue 4No.129Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young青年成熟期糖尿病家族的表型异质性与多基因风险评分DOI: 10.1210/jcemcr/luag001
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.130Obesity and Knee Arthroplasty: One Size Does Not Fit All-A Review with an Indian Perspective肥胖与膝关节置换术：一刀切并不适用——从印度视角的综述DOI: 10.1007/s43465-025-01669-y
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.131Functional Outcome of Single Bundle ACL Reconstruction with Superficial Quadriceps Tendon Graft in an Indian Cohort: A 3-Year Study印度队列中浅层股四头肌肌腱单束前交叉韧带重建的功能结果：一项为期3年的研究DOI: 10.1007/s43465-026-01750-0
Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.132Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes胰高血糖素样肽-1受体激动剂与全膝关节置换术结局：一项系统综述和荟萃分析DOI: 10.1007/s43465-025-01646-5
Frontiers in public health IF: 03.400Volume 14, Issue No.133From gene to plate in Indonesia: a food system framework for the triple burden of malnutrition遗传创新、生物多样性与气候智能型农业：秘鲁、印度尼西亚和南非应对三重营养不良负担的系统性方法DOI: 10.3389/fpubh.2026.1755411
Curēus IF: 01.300Volume 18, Issue 3No.134Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study术后呼吸抑制（PORD）的共识定义与临床框架：一项电子德尔菲研究DOI: 10.7759/cureus.104612
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.135Effectiveness of a school-based obesity control program among adolescents in Makkah: A pretest-posttest intervention study麦加青少年基于学校的肥胖控制项目的有效性：一项前测-后测干预研究DOI: 10.1016/j.jtumed.2026.03.005
J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.136Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction接受辅助生殖治疗的多囊卵巢综合征女性血清铁蛋白水平的变化DOI: 10.1016/j.jtumed.2026.03.004
Bioinformation IF: 01.900Volume 21, Issue 12No.137Assessment of health management strategies and socioeconomic factors contributing to obesity in urban populations城市人群中健康管理策略及社会经济因素对肥胖的影响评估DOI: 10.6026/973206300215038
ArXivVolume 2026, Issue No.138Modeling Metabolic State Transitions in Obesity Using a Time-Varying Lambda-Omega Framework使用时变λ-Ω框架模拟肥胖中的代谢状态转变https://pubmed.ncbi.nlm.nih.gov/41907585
Frontiers in endocrinology IF: 04.600Volume 17, Issue No.139The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives促黑素激动剂：从临床前失败到肥胖治疗的新兴疗法DOI: 10.3389/fendo.2026.1797586
Frontiers in physiology IF: 03.400Volume 17, Issue No.140Effects of psychophysiological stress on perceptual responses during low-volume high intensity interval exercise: insights from ACTH and cortisol in overweight-to-obese adults低容量高强度间歇运动改善超重和肥胖成人的心理生理应激及感知反应DOI: 10.3389/fphys.2026.1762153
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.141Management of Severe Buried Penis With Bilateral Hernia重度埋藏阴茎合并双侧疝的管理DOI: 10.1097/GOX.0000000000007601
FCVM IF: 02.900Volume 13, Issue No.142The impact of body composition variability on coagulation monitoring in patients on direct oral factor Xa inhibitors for treatment of venous thromboembolism生物信息指导的抗Xa治疗（BIARIVA）中的体成分与凝血监测：一项初步研究DOI: 10.3389/fcvm.2026.1773664
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.143Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study台湾动脉粥样硬化性心血管疾病患者二级预防中低密度脂蛋白胆固醇目标达标率研究——基于长庚研究数据库DOI: 10.6515/ACS.202603_42(2).20251012A
Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.144Pharmacokinetics, efficacy, and safety of arsenic formulations in acute promyelocytic leukemia treatment急性早幼粒细胞白血病治疗中砷制剂的药代动力学、有效性和安全性DOI: 10.1080/17512433.2026.2652979
Kidney medicine IF: 03.400Volume 8, Issue 4No.145SGLT2 Inhibitors, Muscle Loss, and Creatinine-Based Estimated GFR: An Integrative Conceptual Review of Renoprotection基于肌酐的eGFR终点评估中肌肉质量流失对SGLT2抑制剂肾脏保护作用的影响DOI: 10.1016/j.xkme.2026.101297
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.146Safety and efficacy of tirzepatide in transplant recipients: a systematic review and meta-analysis替尔泊肽在实体器官移植受者中的安全性和有效性：一项系统综述和荟萃分析DOI: 10.3389/fphar.2026.1735987
Pediatrics international IF: 00.900Volume 68, Issue 1No.147A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications用于新生儿败血症的非手术盲肠浆模型：病理生理学见解与治疗应用DOI: 10.1111/ped.70381
Frontiers in reproductive health IF: 02.900Volume 8, Issue No.148Correction: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome修正：芪功丸在增强多囊卵巢综合征大鼠模型子宫内膜容受性中的作用及潜在机制DOI: 10.3389/frph.2026.1826232
Curēus IF: 01.300Volume 18, Issue 2No.149Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity脂肪性水肿与乳糜泻：全国代表性大样本中的不同表型DOI: 10.7759/cureus.104222
Curēus IF: 01.300Volume 18, Issue 2No.150Necrobiosis Lipoidica in Pregnancy Complicated by Gestational Diabetes Mellitus: A Case Report妊娠期糖尿病合并坏死性类脂质硬化症病例报告DOI: 10.7759/cureus.104273
Curēus IF: 01.300Volume 18, Issue 2No.151Insulin Glulisine Versus Regular Human Insulin for Prednisolone-Associated Hyperglycemia Assessed by Continuous Glucose Monitoring: An Open-Label Crossover Study连续葡萄糖监测评估的赖脯胰岛素与常规人胰岛素治疗泼尼松龙相关高血糖的开放标签交叉研究DOI: 10.7759/cureus.104228
Am J Lifestyle Med IF: 01.300Ahead of Print.No.152Medication Deprescribing Practices Among Lifestyle Medicine Providers: A Cross-Sectional Survey生活方式医学临床医生在启动生活方式医学糖尿病管理后调整降糖药物的调查DOI: 10.1177/15598276261430281
Discover analyticsVolume 4, Issue 1No.153Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees使用皮马印第安人数据库进行糖尿病预测的非线性统计方法比较分析DOI: 10.1007/s44257-026-00057-6
Genom PsychiatryVolume 1, Issue 4No.154Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution白细胞介素1受体拮抗剂（Il1rn）基因表达水平的变化影响循环瘦素浓度和脂肪分布DOI: 10.61373/gp025l.0056
Toxicon X IF: 02.800Volume 30, Issue No.155Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders非洲黑眉蝮蛇（Bitis arietans）毒液金属蛋白酶的生化与免疫学特征DOI: 10.1016/j.toxcx.2026.100253
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.156Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico墨西哥基层医疗中2型糖尿病相关并发症累积负担及健康相关生活质量研究：一项横断面研究DOI: 10.3389/fcdhc.2026.1773692
3 biotech IF: 02.900Volume 16, Issue 4No.157α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetesα-葡萄糖苷酶抑制剂：识别2型糖尿病的关键靶点和机制DOI: 10.1007/s13205-026-04772-5
Frontiers in medicine IF: 03.000Volume 13, Issue No.158Skin lesions in patients treated with growth hormone and those with growth hormone excess: a current overview接受生长激素治疗患者及生长激素过多患者的皮肤表现：当前综述DOI: 10.3389/fmed.2026.1777658
Neurochemical research IF: 03.800Volume 51, Issue 2No.159Vitamin D(3) Attenuates Alzheimer's Disease-Like Pathology via Remodeling Amyloid Protein Production and Clearance Pathway in Wistar Rats维生素D₃通过重塑淀粉样蛋白产生与清除途径减轻Wistar大鼠的阿尔茨海默病样病理DOI: 10.1007/s11064-026-04721-x
Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.160Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus发作性偏身肌张力障碍作为既往未诊断糖尿病的首发表现DOI: 10.5334/tohm.1185
Curēus IF: 01.300Volume 18, Issue 2No.161Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up GapGLP-1受体激动剂疗法停药后的体重反弹：失败、生理机制还是随访缺口DOI: 10.7759/cureus.104259
Int J Nephrol Renovasc Dis IF: 02.500Volume 19, Issue No.162Current Insights and Future Directions on the Role of GLP-1 Receptor Agonists in Chronic Kidney DiseaseGLP-1受体激动剂在慢性肾脏病中的应用现状与未来方向DOI: 10.2147/IJNRD.S522424
Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.163The Glucagon-like Peptide-1 Receptor Agonist Era and Its Influence on Body-Contouring Referrals After Weight Loss in Appalachia胰高血糖素样肽-1受体激动剂时代及其对阿巴拉契亚地区减重后体型塑造转诊的影响DOI: 10.1097/GOX.0000000000007620
Int J Gen Med IF: 02.000Volume 19, Issue No.164Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study内皮蛋白C受体（EPCR）多态性rs867186与2型糖尿病患者血浆可溶性EPCR水平及血液学参数的关联DOI: 10.2147/IJGM.S566052
Curēus IF: 01.300Volume 18, Issue 2No.165Fulminant Toxic Megacolon Without Identifiable Underlying Cause Requiring Emergent Total Colectomy: A Case Report暴发性中毒性巨结肠无明确根本病因需紧急全结肠切除一例报告DOI: 10.7759/cureus.104288
Curēus IF: 01.300Volume 18, Issue 2No.166A Rare Case of Tirzepatide-Associated Immune Thrombocytopenia替尔泊肽相关免疫性血小板减少症的罕见病例DOI: 10.7759/cureus.104281
Curēus IF: 01.300Volume 18, Issue 2No.167Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study老年2型糖尿病患者在三级医院的处方模式：一项真实世界观察性研究DOI: 10.7759/cureus.104264
Curēus IF: 01.300Volume 18, Issue 2No.168X-ray Findings in a Case of Acute Osteomyelitis Following Puncture Injury: A Case Report穿刺伤后急性骨髓炎一例的X线表现：病例报告DOI: 10.7759/cureus.104291
Curēus IF: 01.300Volume 18, Issue 2No.169Where Is the Lactate Coming From? An Unusual Presentation of Persistent Lactic Acidosis乳酸从何而来？持续性乳酸酸中毒的罕见表现DOI: 10.7759/cureus.104328
Curēus IF: 01.300Volume 18, Issue 2No.170Understanding Diabetes Distress: A Study of Contributing Factors Among Adults With Type 2 Diabetes in Rural East Godavari, Andhra Pradesh印度安得拉邦农村地区2型糖尿病成年患者糖尿病困扰的患病率及相关因素DOI: 10.7759/cureus.104183
Curēus IF: 01.300Volume 18, Issue 2No.171Determinants of Left Ventricular Diastolic Dysfunction in Normotensive Patients With Type 2 Diabetes Mellitus: A Tertiary Hospital-Based Study in Ghana正常血压2型糖尿病患者左心室舒张功能障碍的决定因素：基于加纳一家三级医院的研究DOI: 10.7759/cureus.104317
J Public Health ResVolume 15, Issue 1No.172Traditional diets and cultural beliefs affecting diabetes prevention and control in Africa撒哈拉以南非洲2型糖尿病预防与控制：传统非洲饮食和以社区为中心的方法综合综述DOI: 10.1177/22799036261430965
Bioinformation IF: 01.900Volume 21, Issue 12No.173Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction使用瑜伽管理2型糖尿病：对免疫和自主神经功能障碍的影响DOI: 10.6026/973206300214777
Bioinformation IF: 01.900Volume 21, Issue 12No.174Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease唾液和血清碱性磷酸酶作为2型糖尿病的生物标志物：与牙周健康和疾病的关联DOI: 10.6026/973206300214559
Bioinformation IF: 01.900Volume 21, Issue 12No.175Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus印度2型糖尿病患者抗氧化酶活性的评估DOI: 10.6026/973206300215029
Bioinformation IF: 01.900Volume 21, Issue 12No.176Integrative management of chronic kidney disease: A case study combining siddha and modern medicine慢性肾脏病的综合管理：结合悉达（传统）医学与现代医学的案例研究DOI: 10.6026/973206300214344
Clinical ophthalmology IF: 02.200Volume 20, Issue No.177Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks胰高血糖素样肽-1受体激动剂降低2型糖尿病合并心血管风险因素患者的法律失明风险DOI: 10.2147/OPTH.S581826
Front Mol Biosci IF: 04.000Volume 13, Issue No.178Non-coding RNA biomarkers in resistant hypertension: a scoping review抵抗性高血压中的循环非编码RNA生物标志物：一项范围综述DOI: 10.3389/fmolb.2026.1786399
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.179Real-World Effectiveness and Safety of Imeglimin in Type 2 Diabetes: Prospective Multi-Center Study in Bangladesh伊格列净在2型糖尿病中的真实世界观察性研究——孟加拉国患者DOI: 10.2147/DMSO.S576436
Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.180Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study1型糖尿病女性分娩后一年内白细胞端粒显著缩短：一项前瞻性队列研究DOI: 10.3389/fcdhc.2026.1776531
Journal of inflammation research IF: 04.100Volume 19, Issue No.181Diagnosis and Management of Comorbid Autoimmune Disorders in Children with Chronic Spontaneous Urticaria儿童慢性自发性荨麻疹患者合并自身免疫性疾病的诊断与管理DOI: 10.2147/JIR.S558731
Frontiers in veterinary science IF: 02.900Volume 13, Issue No.182Case Report: Bexagliflozin as an adjunct decongestive strategy in a cat with congestive heart failure and advanced chronic kidney disease病例报告：贝格列净作为伴充血性心力衰竭和晚期慢性肾脏病猫的辅助减充血策略DOI: 10.3389/fvets.2026.1791139
FCVM IF: 02.900Volume 12, Issue No.183Safety and efficacy of physical activity in hypertrophic cardiomyopathy patients: a systematic review and metanalysis肥厚型心肌病患者的运动：安全性和有效性的荟萃分析DOI: 10.3389/fcvm.2025.1739956
Kidney international reports IF: 05.700Volume 11, Issue 5No.184Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE卡格列净对基于胱抑素C的估算肾小球滤过率斜率的影响DOI: 10.1016/j.ekir.2026.106374
Circulation IF: 38.600Ahead of Print.No.185Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study奥雷沙恩抑制载脂蛋白C-III对冠状动脉粥样硬化的影响：Essence-TIMI 73b成像研究DOI: 10.1161/CIRCULATIONAHA.126.080012
Frontiers in nutrition IF: 05.100Volume 13, Issue No.186Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial绿原酸富集的咖啡果渣提取物改善高脂血症和肥胖成人的脂质谱：一项随机、双盲、安慰剂对照试验DOI: 10.3389/fnut.2026.1755054
Curēus IF: 01.300Volume 18, Issue 2No.187Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use左乙拉西坦使用后部分症状改善的脑干出血继发霍姆斯震颤DOI: 10.7759/cureus.104226
Frontiers in pharmacology IF: 04.800Volume 17, Issue No.188Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain加巴喷丁中枢神经系统暴露和镇痛反应受慢性神经病理性疼痛患者中OCT2基因型调节DOI: 10.3389/fphar.2026.1760901
Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.189GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov StudiesGLP-1受体激动剂在2型糖尿病老年患者中的应用：4期临床试验的定性分析DOI: 10.2147/DMSO.S584052
NEJM IF: 78.500Ahead of Print.No.190IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease血管内超声引导与血管造影引导在无保护左主干冠状动脉疾病中的经皮冠状动脉介入治疗比较DOI: 10.1056/NEJMoa2600440
Current obesity reports IF: 11.000Volume 15, Issue 1No.191Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment超越体重秤：在循证肥胖治疗中设定超越体重的结局目标DOI: 10.1007/s13679-026-00706-7
Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.192Hypothalamus-liver talks: whispers in the language of metabolism下丘脑-肝脏对话：代谢语言中的低语DOI: 10.1007/s11154-026-10031-y
J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.193In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor桃花心木中分离的柠檬苦素作为潜在α-葡萄糖苷酶抑制剂的计算机和体外研究DOI: 10.1007/s10822-026-00785-7
Journal of molecular modeling IF: 02.500Volume 32, Issue 4No.194Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers槲皮素-ZnO纳米杂化物中Stokes诱导斯塔克场的量子建模用于慢性糖尿病足溃疡的无偏生物电修复DOI: 10.1007/s00894-026-06693-9
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.195Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction射血分数保留的重度主动脉瓣狭窄患者经导管主动脉瓣置换术后，有创测量的血流梯度模式对临床终点及心室重构的影响DOI: 10.1007/s00392-026-02881-y
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.196Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study居住噪声污染对早发性心肌梗死风险的影响——DECIBEL-MI研究结果DOI: 10.1007/s00392-026-02902-w
Clinical Research in Cardiology IF: 03.700Ahead of Print.No.197Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden导管消融对心房颤动的心脏心室电活动的影响：室性早搏负荷评估DOI: 10.1007/s00392-026-02906-6
Inflammopharmacology IF: 05.300Ahead of Print.No.198Enhanced wound healing in diabetic rats using Boswellia serrata Roxb.- Zn gel: a multifunctional approach targeting inflammation, oxidative stress, and tissue regeneration使用乳香提取物-锌凝胶增强糖尿病大鼠伤口愈合：针对炎症、氧化应激和组织再生的多功能方法DOI: 10.1007/s10787-026-02214-5
Infectious diseases and therapy IF: 05.300Ahead of Print.No.199Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations海湾合作委员会国家老年人呼吸道合胞病毒免疫策略：专家共识与建议DOI: 10.1007/s40121-026-01313-8
J Muscle Res Cell Motil IF: 01.700Volume 47, Issue 2No.200Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化及代谢表型的影响：一项概念验证研究DOI: 10.1007/s10974-026-09729-y
Pancreas IF: 01.700Ahead of Print.No.201Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning全宏基因组分析通过机器学习识别慢性胰腺炎的肠道微生物特征DOI: 10.1097/MPA.0000000000002618
Kidney360 IF: 03.000Volume 7, Issue 3No.202Erosion of Immune Regulation in Diabetic Kidney Disease糖尿病肾病中免疫调节的侵蚀DOI: 10.34067/KID.0000001182
Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.203The ABOARD-RWD infrastructure: Using linked real-world data to study the diagnosis and management of dementiaABOARD-RWD基础设施：利用链接的真实世界数据研究痴呆症的诊断与管理DOI: 10.1177/13872877261429858
Alcohol and alcoholism : IF: 02.200Volume 61, Issue 3No.204Moderate-to-heavy habitual alcohol use appears to be detrimentally associated with inflammation even when accounting for diet quality in humans: findings from an observational intensive longitudinal study中度至重度习惯性饮酒即使在考虑饮食质量时也与炎症呈不利关联：一项观察性强化纵向研究的结果DOI: 10.1093/alcalc/agag015
The Journal of school health IF: 01.800Volume 96, Issue 5No.205Evaluation of the Impact of a Psychoeducational Program on Type 1 Diabetes in Italian Schools: A Pre-Post Study评估心理教育项目对意大利学校1型糖尿病的影响：一项前后测研究DOI: 10.1111/josh.70141
The Journal of rural health IF: 02.700Volume 42, Issue 2No.206Barriers to consulting for symptoms of possible colorectal cancer among rural patients in England: A cross-sectional survey英格兰农村患者对可能结直肠癌症状咨询的障碍：一项横断面调查DOI: 10.1111/jrh.70142
Advanced materials IF: 26.800Ahead of Print.No.207AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound HealingAI引导的4D打印受食肉植物启发的微针用于加速伤口愈合DOI: 10.1002/adma.202523665
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.208Comparative Efficacy of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Conventional Therapy in Chronic Non-Healing Skin Ulcers: A Randomised Clinical Trial富血小板血浆、富血小板纤维蛋白与常规治疗在慢性难愈性皮肤溃疡中的比较有效性：一项随机临床试验DOI: 10.1111/wrr.70151
Nephrol Dial Transplant IF: 05.600Ahead of Print.No.209Better cardiorenal protection for patients with CKD and type 1 diabetes对慢性肾病合并1型糖尿病患者更好的心肾保护DOI: 10.1093/ndt/gfag076
J Am Coll Surg IF: 03.400Ahead of Print.No.210Unraveling Metabolic Syndrome解读代谢综合征DOI: 10.1097/XCS.0000000000001952
J Prim Care Community Health IF: 02.500Volume 17, Issue No.211Self-Reported Depression, Anxiety, Stress, Health-Related Quality of Life, and Diabetes Distress During a 2-Year Pedometer-Based Physical Activity Intervention in Prediabetes and Type 2 Diabetes: Secondary Outcomes of a Randomized Controlled Trial针对前驱糖尿病和2型糖尿病患者的为期2年基于计步器的体力活动干预中自我报告的抑郁、焦虑、压力、健康相关生活质量及糖尿病困扰：随机对照试验的次要结局DOI: 10.1177/21501319261434134
Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.212NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney DiseaseNBL1与小鼠肾脏表型相关，但部分Nbl1减少并不能改善肾脏疾病DOI: 10.1152/ajprenal.00465.2025
J Geriatr Psychiatry Neurol IF: 02.500Ahead of Print.No.213The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis创伤后应激障碍作为痴呆风险因素的作用：一项荟萃分析DOI: 10.1177/08919887261435186
Pancreas IF: 01.700Ahead of Print.No.214Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records使用电子健康记录对胰腺疾病患者的合并症及临床结局进行纵向研究DOI: 10.1097/MPA.0000000000002636
East Mediterr Health J IF: 01.900Volume 32, Issue 3No.215The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region解决东地中海地区体力不活动危机的紧迫性DOI: 10.26719/2026.32.3.127
Gut microbes reportsVolume 2, Issue 1No.216Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history与家族史相关的2型糖尿病风险梯度中肠道菌群组成DOI: 10.1080/29933935.2025.2527766
Gut microbes reportsVolume 2, Issue 1No.217Toxic metals impact gut microbiota and metabolic risk in five African-origin populations非洲起源个体中的有毒金属暴露、肠道微生物群与心脏代谢风险DOI: 10.1080/29933935.2025.2481442
Frontiers in big data IF: 02.300Volume 9, Issue No.218FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detectionFunduScope：一种以人为主导、基于机器学习的交互式工具，用于培训初级眼科医生进行糖尿病视网膜病变检测DOI: 10.3389/fdata.2026.1676922
Food Science and Biotechnology IF: 03.100Volume 35, Issue 5No.219Multifaceted role of plant polyphenols in human health: a comprehensive review植物多酚在人类健康中的多方面作用：综述DOI: 10.1007/s10068-025-01991-z
Curēus IF: 01.300Volume 18, Issue 2No.220When Drainage is Not Enough in Emphysematous Pyelonephritis Complicated by Necrotizing Fasciitis: A Case Report气肿性肾盂肾炎并发坏死性筋膜炎时引流不足：一例报告DOI: 10.7759/cureus.104189
Journal of Cardiac Failure IF: 08.200Ahead of Print.No.221Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients with Obesity and HFpEF肥胖和射血分数保留的心力衰竭（HFpEF）患者的脂肪分布与肺毛细血管楔压的体位变化DOI: 10.1016/j.cardfail.2026.03.029
JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.222The Liraglutide Effects in Atrial Fibrillation (LEAF) Study利拉鲁肽对心房颤动（LEAF）研究的影响DOI: 10.1016/j.jacep.2026.03.026
World journal of surgery IF: 02.500Ahead of Print.No.223Enhanced Recovery After Surgery (ERAS) Protocol for Abdominal Wall Reconstruction. A Scoping Review of Items Included in Current Protocols腹部重建术后的加速康复（ERAS）方案：当前方案中包含项目的范围综述DOI: 10.1002/wjs.70356
Diabetic medicine IF: 03.400Ahead of Print.No.224'Darkness as we face the unknown': Biopsychosocial-spiritual experiences of parents of children and young people with type 1 diabetes from the Middle East and North Africa (MENA) region面对未知的黑暗：中东和北非（MENA）地区患有1型糖尿病的儿童和青少年的父母的生物-心理-社会-精神体验DOI: 10.1111/dme.70303
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.225How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage谷氨酸和GABA如何“成为”神经递质：一位研究者65年的历程自述DOI: 10.1111/jnc.70325
Clinical endocrinology IF: 02.400Ahead of Print.No.226Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry肾上腺静脉取样期间的明显双侧醛固酮抑制：Liaison化学发光免疫分析法的假象及与另一种商业免疫分析法和质谱法比较揭示的其他原因DOI: 10.1111/cen.70135
World J Biol Psychiatry IF: 03.800Ahead of Print.No.227Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study食欲激素失调对青少年注意力缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究DOI: 10.1080/15622975.2026.2646508
ANZ journal of surgery IF: 01.600Ahead of Print.No.228Patient Reported Outcomes After Total Pancreatectomy With Islet Autotransplantation: A Narrative Review全胰腺切除联合胰岛自体移植术后患者报告结局：一项叙事综述DOI: 10.1111/ans.70638
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.229Multifactorial influence of type 2 diabetes on cardiovascular risk assessed by PolSCORE, SCORE2 in the age group 40-69 years2型糖尿病对40-69岁人群心血管风险的多因素影响（PolSCORE与SCORE2评估）DOI: 10.26444/aaem/205804
Pediatric obesity IF: 02.700Volume 21, Issue 4No.230Metabolic Complications and Ultrasound-Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy杜氏肌营养不良症患儿的代谢并发症及超声检测的肝脏异常DOI: 10.1111/ijpo.70106
Int J Soc Psychiatry IF: 02.700Ahead of Print.No.231Disordered Eating in Patients With Remission Schizophrenia: A Highly Prevalent but Largely Under-Explored Condition Despite Its Potential Relation to Psychopathology缓解期精神分裂症患者的进食障碍：一种高度流行但在很大程度上未被充分探索的疾病，尽管其可能与精神病理学相关DOI: 10.1177/00207640261424409
Gut microbes IF: 11.000Volume 18, Issue 1No.232Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction进食行为失调与针对进食障碍和食物成瘾的基于微生物群的干预措施DOI: 10.1080/19490976.2026.2647535
Pediatric obesity IF: 02.700Volume 21, Issue 4No.233Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children母亲孕前BMI与幼儿前额纹状体连接性的关联DOI: 10.1111/ijpo.70101
Medical science monitor IF: 02.100Volume 32, Issue No.234Social Attitudes Towards Public Health Interventions in Community Pharmacies in Poland: A Nationwide Cross-Sectional Survey波兰社区药房公共卫生干预措施的社会态度：全国横断面调查DOI: 10.12659/MSM.951732
Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.235Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors可卡因诱导伏隔核中即早基因表达：不同cAMP传感器的作用DOI: 10.1111/jnc.70374
Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.236Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group减重手术后妊娠的围产期结局与匹配对照组比较DOI: 10.1111/ajo.70117
Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.237Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes自体血凝块疗法治疗伤口：研究其对糖尿病患者外周血单核细胞和成纤维细胞的趋化作用DOI: 10.1111/wrr.70153
European journal of neurology IF: 03.900Volume 33, Issue 4No.238Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors普通成年人群中的主观记忆障碍：与早年认知、同期客观记忆及痴呆风险因素的关联DOI: 10.1111/ene.70556
European journal of pain IF: 03.400Volume 30europeanjournalofpain, Issue 4, Page e70252-e70262No.239Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals短期睡眠中断不会改变健康个体对实验性膝关节疼痛的反应DOI: 10.1002/ejp.70260
Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.240Effect of overweight and obesity on clinical course and prognosis in patients with acute coronary syndromes超重和肥胖对急性冠脉综合征患者临床进程及预后的影响DOI: 10.26444/aaem/213894
Journal of food science IF: 03.400Volume 91, Issue 4No.241A Critical Review of Antidiabetic Properties of Tempeh From Various Substrates各种底物发酵天贝的抗糖尿病特性批判性综述DOI: 10.1111/1750-3841.71014
Clinical toxicology IF: 03.300Ahead of Print.No.242Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose临床毒理学推荐协作组关于急性口服过量中毒中活性炭给药的建议DOI: 10.1080/15563650.2025.2609807
Hypertension IF: 08.200Ahead of Print.No.243Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity饮食钠调节的血浆SVEP1与反向盐敏感性DOI: 10.1161/HYPERTENSIONAHA.125.26827
Natural product research IF: 01.600Ahead of Print.No.244Harnessing mangroves for epigenetic therapies利用红树林进行表观遗传疗法DOI: 10.1080/14786419.2026.2649921
Brain : IF: 11.700Ahead of Print.No.245Synapse-associated neuropathological markers in Alzheimer disease阿尔茨海默病中突触相关的神经病理标志物DOI: 10.1093/brain/awag117
European Journal of Immunology IF: 03.700Volume 56, Issue 4No.246Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis系统性I型干扰素阻断可减轻银屑病临床前模型中的胰岛素抵抗DOI: 10.1002/eji.70160
The FASEB journal : IF: 04.200Volume 40, Issue 7No.247Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages肥胖破坏缺氧巨噬细胞中H3K4me3介导的乳酸积累和胞葬作用DOI: 10.1096/fj.202502626R
Journal of health psychology IF: 02.200Ahead of Print.No.248Technology readiness associated with insulin pump and automated insulin delivery system use in young adults with type 1 diabetes与1型糖尿病青年成年人胰岛素泵及自动化胰岛素递送系统使用相关的技术准备度DOI: 10.1177/13591053261433230
Diabetic medicine IF: 03.400Ahead of Print.No.249Exploring inequities in access to diabetes technologies among children and young people with type 1 diabetes: Perspectives of parents and young people from ethnic minority groups and low socio-economic areas探索1型糖尿病儿童和青少年获取糖尿病技术的不平等：少数族裔及低社会经济区域群体父母与青少年的视角DOI: 10.1111/dme.70304
Medeniyet medical journal IF: 01.100Volume 41, Issue 1No.250Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对新诊断1型糖尿病儿童糖尿病酮症酸中毒的影响：一项前瞻性多中心研究DOI: 10.4274/MMJ.galenos.2026.55256
211
Diabetes Mellitus(DM)
糖尿病
103
Obesity
肥胖症
70
Insulin
胰岛素
32
Type 2 diabetes mellitus(T2DM)
2型糖尿病
18
Metformin
二甲双胍
16
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
13
Metabolic Syndrome
代谢综合征
13
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
8
Semaglutide
司美格鲁肽
8
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
7
Hypoglycemic Agents
降糖药
7
Diabetic Retinopathy
糖尿病视网膜病
5
Diabetic Foot
糖尿病足
5
Liraglutide
利拉鲁肽
4
Tirzepatide
替尔泊肽
3
Dulaglutide
度拉糖肽
3
Diabetes Complications
糖尿病并发症
2
Diabetic Cardiomyopathies
糖尿病心肌病
2
gamma-Aminobutyric Acid(GABA)
γ-氨基丁酸
2
Gabapentin
加巴喷丁
2
Exenatide
艾塞那肽
2
Type 1 diabetes mellitus(T1DM)
1型糖尿病
1
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
1
Sitagliptin
西他列汀
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
1
Diabetic Peripheral Neuropathy(PDN)
糖尿病周围神经病变
1
Diabetic Neuropathies
糖尿病性神经病变
1
Diabetic acidosis
糖尿病性酸中毒
1
Bexagliflozin
贝沙格列净
1
Canagliflozin
卡格列净
1
Dapagliflozin
达格列净
编辑：韩玉莲
审校：韩玉莲
临床结果临床3期
2026-03-30
导读
在肿瘤研究与创新药开发领域，VEGF 一直是一个绕不开的关键词。它既是肿瘤血管生成研究中最经典的分子之一，也是临床上被反复验证、持续拓展的成熟成药通路。过去，VEGF 更多被理解为抗血管生成治疗的核心靶点；而在今天，随着肿瘤微环境、免疫抑制机制以及联合治疗策略研究不断深入，VEGF 的意义早已不再局限于“抑制新生血管”，而是逐渐演变为连接肿瘤血管异常、免疫逃逸和联合治疗设计的重要枢纽。相关研究验证了 VEGF/VEGFR 轴在肿瘤血管生成及转化开发中的核心地位[1]。
从药物开发史看，VEGF 通路之所以能长期保持热度，并不是因为它“新”，而恰恰因为它“足够重要且已被验证有效”。早在2004年，贝伐珠单抗就成为首个在美国获批、用于肿瘤抗血管生成治疗的 VEGF 靶向药物；此后，这一通路不断从肿瘤延展到眼科等疾病领域，并在双抗、联合免疫治疗等新策略中焕发出新的临床价值[2]。到了2024至2026年，以PD-1/VEGF 双特异性抗体为代表的新一代分子持续推动 VEGF 赛道升温，也让这一经典通路重新站上创新前沿。
背景概述
VEGF即vascular endothelial growth factor，常译为“血管内皮生长因子”。它并不是单一分子，而是一个家族，其中 VEGF-A 是研究最深入、在肿瘤和药物研发中最具代表性的核心成员[2]。VEGF-A 最早因其对血管内皮细胞具有显著促增殖作用而受到关注，随后大量研究表明，它在血管生成、血管通透性调控以及胚胎血管发育中都发挥着关键作用。也正因如此，VEGF-A 被广泛视为病理性血管生成的核心驱动因子之一。
在肿瘤微环境中，VEGF-A 的异常高表达可推动肿瘤周围形成大量结构异常、功能紊乱的新生血管。这些血管虽然为肿瘤持续生长提供了氧气和营养，但同时也会带来高通透性、低灌注、局部缺氧和免疫抑制等一系列问题，从而进一步促进肿瘤进展、转移和治疗耐受。因此，VEGF 的临床价值并不在于把它简单理解为“通用肿瘤早筛标志物”，而在于它是异常血管生成和肿瘤微环境重塑中的关键生物学节点，也是极具成药价值的核心通路[3]。
VEGF 家族与受体网络
VEGF 家族主要包括 VEGF-A、VEGF-B、VEGF-C、VEGF-D 和胎盘生长因子 PlGF[4]。它们通过与 VEGFR-1、VEGFR-2、VEGFR-3 等受体结合，参与血管生成或淋巴管生成等生物学过程。其中，VEGFR-2 被普遍认为是介导 VEGF-A 促血管生成作用的最关键受体，而 VEGFR-1、VEGFR-3 以及 neuropilin 等辅受体则在不同组织、不同病理状态下参与更精细的信号调节[5]。围绕这一配体-受体网络构建治疗策略，是 VEGF 靶向药物研发长期成功的重要基础。
从机制上看，VEGF/VEGFR 轴不仅影响内皮细胞增殖和迁移，还会调节血管通透性、内皮细胞存活以及局部微环境状态[5]。正因为这一通路同时连接“肿瘤供血”和“微环境调节”两大核心问题，它才会在过去二十多年里持续成为肿瘤药物开发中的高价值靶点。无论是单抗、受体陷阱蛋白，还是近年来更受关注的双特异性抗体，其研发逻辑本质上都建立在对 VEGF 家族与受体网络的深入理解之上。
图1. VEGF家族成员与受体网络示意图[4]
核心信号通路
如果说 VEGF 是肿瘤血管生成的“启动信号”，那么 VEGF 信号通路就是把这一信号真正转化为血管生长、血管异常和微环境重塑的执行系统。在整个家族中，VEGF-A 与 VEGFR-2 结合后诱导受体二聚化和酪氨酸激酶结构域磷酸化，被认为是促血管生成作用最经典、最核心的信号起点[6]。
VEGF-A 激活 VEGFR-2 后，可进一步牵动多条下游通路。其一是 PLCγ–PKC–MAPK/ERK 轴，主要促进内皮细胞增殖；其二是 PI3K–AKT 轴，更多参与细胞存活、抗凋亡以及血管功能维持[7]；此外，Src 相关信号及其他骨架重塑网络还可增强血管通透性并促进内皮细胞迁移。这些信号共同作用，最终推动血管芽生、分支形成以及异常血管网络扩张。在肿瘤中，VEGF 信号长期过度激活，常常导致血管结构紊乱、通透性过高、灌注效率低下以及肿瘤局部持续缺氧。这样的微环境一方面促进肿瘤侵袭和转移，另一方面也会妨碍免疫细胞有效浸润，削弱免疫治疗效果[8]。
图2. VEGF下游经典信号通路[8]
VEGF药物研发进展
VEGF 靶向治疗的价值，首先来自其扎实的临床验证基础。贝伐珠单抗于 2004 年 2 月获美国 FDA 批准用于转移性结直肠癌一线治疗，成为首个获批的抗肿瘤血管生成药物之一，也标志着抗 VEGF 治疗正式进入临床主流视野。此后，围绕 VEGF 或 VEGFR 的药物不断扩展至多种实体瘤和眼科疾病，逐步建立起成熟的临床应用基础。在肿瘤领域，VEGF 的“再度升温”则主要来自与免疫治疗的深度融合。随着研究者逐渐认识到 VEGF 不仅影响血管生成，还可参与免疫抑制微环境塑造，PD-1/VEGF 双通路协同阻断的开发逻辑开始越来越清晰：一方面通过 PD-1 通路解除 T 细胞抑制，另一方面通过 VEGF 通路改善异常血管和免疫抑制环境，从而在同一分子层面实现免疫激活与微环境重塑[9]。
截至目前，VEGF 赛道最受关注的前沿方向之一，无疑是 PD-1/VEGF 双特异性抗体。依沃西单抗（ivonescimab）是其中最具代表性的产品之一。公开资料显示，它于 2024年5月在中国获得首次批准，用于 EGFR 突变、经 EGFR-TKI 治疗后进展的局部晚期或转移性非鳞状 NSCLC；随后又于 2025年4月在中国获批用于 PD-L1 阳性 NSCLC 一线治疗[10]。
进入2026年后，该方向的临床与注册推进仍在持续。Akeso 于2026年2月5日公布，依沃西单抗联合化疗获得中国 NMPA 第五项突破性治疗认定，适用于晚期胆道癌一线治疗。与此同时，公司又在2026年3月公布多项以 ivonescimab 或 cadonilimab 为基础骨干疗法、联合新一代 ADC 的 II 期研究启动信息，显示 VEGF 相关双抗正进一步从“单药竞争”走向“联合治疗平台”[10]。
无论是经典抗 VEGF 单抗、VEGF Trap 类药物，还是以 PD-1/VEGF 双抗为代表的新一代创新分子，真正决定研发效率的，除了分子本身的设计质量，还包括是否具备可以准确反映靶点生物学和药效差异的体内评价体系。尤其是在双靶点药物开发中，研究者往往不仅要关注肿瘤体积变化，还要同步观察血管相关表型、免疫微环境变化以及人源靶点表达状态，这对模型平台提出了更高要求。
基于这一研发需求，百奥动物围绕 VEGFA 及 PD-1/PD-L1 相关通路建立了可用于药效评价的模型体系，为相关疾病提供更优的临床治疗选择。部分模型数据如下：
B-hVEGFA/hPD-L1 B16-F10
肿瘤生长曲线与体重变化
B-hVEGFA/hPD-L1 B16-F10细胞的皮下肿瘤生长。将B-hVEGFA/hPD-L1 B16-F10细胞（1×105）和野生型B16-F10细胞（1×105）皮下植入C57BL/6小鼠（雌性，6周龄，n=8）体内。每周测量两次肿瘤体积和体重。（A）平均肿瘤体积；（B）体重。体积以mm3表示，公式为：V=0.5×长径×短径^2。结果表明，B-hVEGFA/hPD-L1 B16-F10能够在体内形成肿瘤，可用于疗效研究。数值表示为平均值±标准误（SEM）。
B-hVEGFA/hPD-L1 B16-F10细胞皮下肿瘤生长。将B-hVEGFA/hPD-L1 B16-F10（1×105）细胞和野生型B16-F10（1×105）细胞皮下植入B-hPD-1/hPD-L1/hVEGFA小鼠（雄性，7-9周龄，n=8）体内。每周测量两次肿瘤体积和体重。（A）平均肿瘤体积；（B）体重。体积以mm3表示，公式为：V=0.5×长径×短径^2。结果表明，B-hVEGFA/hPD-L1 B16-F10能够在体内形成肿瘤，可用于疗效研究。数值表示为平均值±标准误（SEM）。
肿瘤中mVEGFA/hVEGFA的表达分析
实验结束时收集肿瘤细胞，并通过ELISA检测小鼠和人VEGFA的表达。如图所示，人VEGFA在B-hVEGFA/hPD-L1 B16-F10肿瘤匀浆中持续高表达，表达水平超过每毫克总蛋白2000皮克。数据以平均值±标准误（SEM）表示。
依沃西单抗在B-hPD-1/hPD-L1/hVEGFA小鼠体内的药效研究
依沃西单抗（Ivonescimab，AK112）在B-hPD-1/hPD-L1/hVEGFA小鼠中的抗肿瘤活性。将小鼠黑色素瘤细胞B-hVEGFA/hPD-L1 B16-F10皮下植入纯合B-hPD-1/hPD-L1/hVEGFA小鼠（雌性，8周龄，n=6）体内。当肿瘤体积达到约150 mm3时，将小鼠分组，并按照图示腹腔注射依沃西单抗。如图A所示，依沃西单抗在控制B-hPD-1/hPD-L1/hVEGFA小鼠的肿瘤生长方面有效。数值表示为平均值±标准误（SEM）。注意：G3组在第12天有一只小鼠死亡。
除此之外，我们也开发了其他的模型，用于药效研究。
B-hVEGFA MC38
依沃西单抗在B-hPD-1/hPD-L1小鼠中的抗肿瘤活性。当肿瘤体积达到约400 mm3时，将小鼠分组，并在此时间点通过腹腔注射图示抗体。如图所示，依沃西单抗在控制B-hPD-1/hPD-L1小鼠的肿瘤生长方面有效。
B-hVEGFA/hPD-L1 plus MC38
依沃西单抗在B-hPD-1/hPD-L1/hVEGFA小鼠中的抗肿瘤活性。将小鼠结肠癌B-hVEGFA/hPD-L1细胞与MC38细胞混合后，皮下植入纯合B-hPD-1/hPD-L1/hVEGFA小鼠（雄性，8周龄，n=5）体内。当肿瘤体积达到约300 mm3时，将小鼠分组，并按照图示腹腔注射依沃西单抗。如图A所示，与单一疗法相比，依沃西单抗表现出更优的抗肿瘤效果。数值表示为平均值±标准误（SEM）。
从基础研究中的血管生成关键因子，到肿瘤治疗中的经典靶点，再到双特异性抗体时代的重要组合节点，VEGF 的价值正在被不断重新定义。它不再只是一个“老靶点”，而是连接血管生成、肿瘤微环境、免疫调控和联合治疗策略的重要枢纽。
随着 PD-1/VEGF 双抗、VEGF/Ang-2 双抗以及更多围绕 VEGF 通路的联合方案持续推进，VEGF 赛道也正在进入新的竞争阶段。对于创新药研发而言，围绕这一通路开展更精准的分子设计与更高质量的体内评价，将成为下一轮突破的关键。而百奥动物持续深耕相关模型构建与评价体系优化，也将为靶向 VEGFA 及其相关双机制药物的临床前研究提供更有力的支持。
VEGF靶点相关模型
参考文献
[1] Nilsson MB, Heymach JV. Vascular endothelial growth factor (VEGF) pathway. J Thorac Oncol. 2006.
[2] Ferrara N. VEGF-A: a critical regulator of blood vessel growth[J]. European cytokine network, 2009, 20(4): 158-163.
[3] Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003.
[4] Brogowska KK, et al.Vascular Endothelial Growth Factor Ligands and Receptors in Breast Cancer.Int J Mol Sci.2023 Mar 21;12(6):2412.
[5] Wang X, Bove AM, Simone G, Ma B. Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role. Front Cell Dev Biol. 2020.
[6] Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal. 2007.
[7] Abhinand CS, Raju R, Soumya SJ, et al. VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis. J Cell Commun Signal. 2016.
[8] Monique and John. Vascular Endothelial Growth Factor (VEGF) Pathway[J]. J Thorac Oncol.2006 Oct;1(8):768-70.
[9] https://www.akesobio.com/en/media/akeso-news/250426/?utm_source=chatgpt.com
[10] https://link.springer.com/article/10.1007/s40265-024-02073-w
百奥动物
立足全球生物医药行业，从技术创新出发，百奥赛图建立“BioMice百奥动物”子品牌。百奥动物集创新动物模型研发制备、生产供应和实验服务为一体，拥有4390个独特基因编辑动物/细胞系模型，覆盖肿瘤，自免，代谢，心血管等多个疾病领域，包括重度免疫缺陷B-NDG及系列鼠、靶点人源化鼠、疾病模型鼠及基因敲除鼠等，结合优质的药理药效评价服务及转化医学服务平台，针对靶点类型、抗体亚型与作用机制，可订制个性化项目方案，提供具有广泛实验类型或数据分析结果的体内药效、PK/PD、生物标志物评估、Non-GLP毒理学评估、体外免疫细胞和细胞因子分析以及细胞功能测定，完整的体内药效和体外药理学服务能力能够为药物开发提供完整的PoC和MoA。为全球约950个合作伙伴完成了6350项药物评估项目，已支持了多项IND应用和临床试验。以高标准的3大动物中心为支撑，极大的满足了全球科学研究和药物开发需求。创新的动物模型、高标准的质量管理、多元化的服务平台，助推生物医药创新产业的快速发展。
免疫疗法
2026-03-30
2026年第7期
SCI周报
本周SCI数据库共收录172篇以重医为单位发表的论文，其中以第一单位或通讯单位发文124篇。
第1条，共124条
标题: Cross-tissue multicellular coordination and its rewiring in cancer期刊: NATURE作者: Shi, Q;Chen, YH;Li, Y; et al.通讯作者: Shi, Q; Zhang, ZM (通讯作者)，Peking Univ, Sch Life Sci, Biomed Pioneering Innovat Ctr BIOPIC, Beijing, Peoples R China.; Shi, Q; Zhang, ZM (通讯作者)，Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China.; Zhang, ZM (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.文献类型: Article影响因子: 48.5, JCR分区: Q1, 中信所分区: Q1学院: 重庆医科大学
摘要：支撑组织稳态和疾病进展的多细胞协调是基础性的（1-5）。然而，不同细胞类型如何在组织生态位中组织以实现凝聚功能仍大多未知。我们系统地描述了健康组织中跨组织协调的细胞模块，揭示了它们的时空动态和表型关联，并研究了它们在癌症中的重连。我们首先从35个人类组织编制了一份全面的单细胞转录组图谱，揭示了细胞组成在组织间存在显著的变异性。通过利用细胞丰度的协方差，我们识别出12个具有不同细胞组成、组织流行率和空间组织的细胞模块，并利用原位空间和体内扰动数据展示了细胞模块内协调的细胞间通信。其中，脾脏中的两个免疫细胞模块与衰老形成了对比的年龄动态。对乳腺多细胞变化的分析显示，更年期轨迹与成纤维细胞动态相关。此外，跨癌症类型的探究揭示了肿瘤进展过程中两种多细胞生态系统的同时重塑，包括组织特异性健康组织的丧失和趋同的癌症生态系统的出现。这些发现揭示了多细胞生态系统在健康和癌症中的基本组织原理，为在不同环境中组织层面功能协调的进一步研究奠定了基础。
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第2条，共124条
标题: KDM5B-driven glucose metabolic reprogramming promotes enzalutamide resistance in prostate cancer via the lactate/hnRNPA1 lactylation/AR-V7 axis期刊: MOLECULAR CANCER作者: Sun, R;Huang, Y;He, H; et al.通讯作者: He, WY; Yang, L; Liu, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China.; Gao, YY (通讯作者)，Chongqing Med Univ, Banan Hosp, Dept Clin Lab, Chongqing 401320, Peoples R China.文献类型: Article影响因子: 33.9, JCR分区: Q1, 中信所分区: Q1学院: 附一院; 附一院, 附属巴南医院摘要：恩杂鲁胺（enzalutamide, Enza）用于治疗去势抵抗性前列腺癌（castration-resistant prostate cancer, CRPC），其中组蛋白去甲基化酶5B（KDM5B）表达升高。研究采用了乳酸化蛋白质组学（lactylation proteomics）、CRISPR/Cas9基因编辑技术、染色质免疫沉淀（ChIP）以及双荧光素酶报告基因实验等方法。机制上，KDM5B通过表观遗传抑制第10号染色体缺失的磷酸酶及张力蛋白同源基因（PTEN），进而激活PI3K/Akt信号通路，上调磷酸甘油酸激酶1（PGK1）。乳酸作为底物，通过p300介导不均一核核糖核蛋白A1（hnRNPA1）第179位赖氨酸（K179）的乳酸化修饰，阻断NEDD4L介导的泛素化从而稳定hnRNPA1，促进雄激素受体剪接变异体7（AR-V7）的剪接。此外，雄激素受体（AR）与KDM5B之间形成正反馈调节，而组蛋白去乙酰化酶1/2（HDAC1/HDAC2）与p300共同参与hnRNPA1的乳酸化调控。
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第3条，共124条
标题: The Ly6ghigh Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8+ T Cell Death期刊: CANCER COMMUNICATIONS作者: Wang, R;Liu, XQ;Hou, YX; et al.通讯作者: Wan, XY; Liu, MR (通讯作者)，Chongqing Med Univ, Key Lab Lab Med Diagnost, Chinese Minist Educ, Chongqing 400016, Peoples R China.; Liu, MR (通讯作者)，Western Inst Digital Intelligent Med, Chongqing 401329, Peoples R China.; Shi, ZR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 24.9, JCR分区: Q1, 中信所分区: Q1学院: 检验医学院; 检验医学院, 附一院
摘要：背景：肺转移是乳腺癌（BC）相关死亡率的主要原因之一，主要由转移性肿瘤微环境的免疫抑制性状驱动。然而，细胞间相互作用在形成转移生态位内免疫规避的机制仍不明确。中性粒细胞外陷阱（NET）及其相关蛋白（如碳酸杀菌素）已成为癌症转移调控的关键介质。本研究旨在解析以高表达淋巴细胞抗原6复合体g（Ly6ghigh）为特征的中性粒细胞亚组与通过嵌入NETs的细胞杀死蛋白介导的分化8阳性T淋巴细胞簇（CD8+ T细胞）之间的相互作用，以及它们在促进肺转移中的协同机制和协同作用。方法：我们通过对来自BC肺转移小鼠模型的肺组织进行单细胞RNA测序和流式细胞术，表征了中性粒细胞的异质性和功能动力学。我们利用与Cathelicidin相关的抗菌肽（Cramp）敲除小鼠，解析了NETs中cathelicidin的作用。通过多重免疫荧光分析了凋亡CD8+ T细胞和NETs的空间共定位，并通过蛋白质结合测定探查了分子间相互作用。结果：肺转移生态位中的中性粒细胞根据Ly6g表达被分为两个亚组：Ly6ghigh和Ly6glow中性粒细胞。Ly6glow中性粒细胞在大转移阶段被招募，表现出骨髓系衍生的抑制细胞样特征。值得注意的是，Ly6ghigh中性粒细胞通过NET形成诱导CD8+ T细胞凋亡，凋亡的CD8+ T细胞空间性地聚集在富含NET的区域。机制上，NET来源的cathelicidin（小鼠痉挛）直接结合到CD8+ T细胞中的线粒体腺嘌呤核苷酸转运因子1（Ant1），触发构象变化和与电压依赖性阴离子通道1（Vdac1）的复杂形成。这些事件导致线粒体通透性过渡孔的打开和线粒体膜电位的丧失。结论：本研究表明，Ly6ghigh中性粒细胞通过NET诱导CD8+ T细胞凋亡，在免疫抑制和免疫逃避中起关键作用。这些发现强调了NETs和房铁杀菌素在BC肺转移中的重要性，表明它们在恢复抗肿瘤免疫和预防转移进展方面具有治疗靶点的潜力。
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第4条，共124条
标题: Ultrasound-activated drug delivery systems tackle biofilm-associated infections: Biomaterials engineering and therapeutic mechanisms期刊: COORDINATION CHEMISTRY REVIEWS作者: Xia, CY;Zhou, JL;Wu, NH; et al.通讯作者: Qian, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Pharm, Chongqing 400010, Peoples R China.; Li, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China.; Li, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging & Therapy, Chongqing 400010, Peoples R China.; Chen, Y (通讯作者)，Shanghai Univ, Sch Life Sci, Materdicine Lab, Shanghai 200444, Peoples R China.; Chen, Y (通讯作者)，Shanghai Inst Materdicine, Shanghai 200051, Peoples R China.文献类型: Review影响因子: 23.5, JCR分区: Q1, 中信所分区: Q1学院: 附二院; 附二院
摘要：生物膜相关感染（BAI）对全球健康构成重大挑战，因为传统治疗方案不可避免地因复杂的抗BAI级联挑战和难以解决的药物设计而效果较低。近年来，超声（美）激活药物递送作为一种有前景的解决方案出现，利用其特异的热效应、空蚀和机械效应，提升功能性生物材料药物递送系统（DDSs）的抗BAI性能。然而，多个关键概念仍未明确，包括超声的潜在治疗机制、理性生物材料选择以及超导激活DDS的最优设计原则，严重阻碍了后续药物研发。本综合综述旨在破译复杂的生物膜结构，揭示连锁治疗挑战与可行药物递送策略，阐明美国激活DDS的操作机制及特殊优势，总结晚期模型生物材料选项，重点介绍DDS开发的最新突破，概述未来抗BAIs前景，并提出下一代抗BAIs药物的关键设计原则。通过解决这些方面，本综述希望能够完善先进美国激活DDS的设计理念，探索US与药物递送的最佳融合，为成功的抗BAIs革命铺平高效道路。
第5条，共124条
标题: Mitochondrial-Targeting DNA Origami Delivering TIPE-2 mRNA for Microglial Metabolic Reprogramming and Neurological Recovery in Intracerebral Hemorrhage期刊: ADVANCED FUNCTIONAL MATERIALS作者: Xiao, JN;Wu, MX;Peng, W; et al.通讯作者: Hou, X (通讯作者)，Jiamusi Univ, Sch Basic Med, Jiamusi, Heilongjiang, Peoples R China.; Lai, LF (通讯作者)，Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Neurosurg, Nanchang, Jiangxi, Peoples R China.; Yang, Z (通讯作者)，Chongqing Med Univ, Affiliated Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 19, JCR分区: Q1, 中信所分区: Q1学院: 附属永川医院
摘要：脑内出血（ICH）后的继发性脑损伤由持续的神经炎症和代谢功能障碍驱动，其中异常激活的小胶质细胞形成自我放大循环，损害神经修复。TIPE-2（TNFAIP8样2）是关键的免疫代谢调控因子，但其在中枢神经系统（CNS）中的治疗应用受限于mRNA稳定性差和细胞内靶向效率低下。本研究创新地构建了经三苯基膦（TPP）修饰的DNA折纸纳米结构，用于TIPE-2 mRNA递送（TPP-DNA Origami@TIPE-2），以恢复小胶质细胞的代谢免疫稳态。实验表明，该纳米平台具有高度结构稳定性（48小时内尺寸变化<5%）和高效mRNA负载（82.6%），显著增强线粒体功能（OCR提升76.3%），促进M2小胶质细胞极化（CD206+细胞增加2.5倍），并抑制炎症信号（IL-1 β减少3.8倍）。在小鼠ICH模型中，TPP-DNA Origami@TIPE-2通过激活PGC-1α通路显著改善了神经系统结局，而单细胞RNA测序则揭示了小胶质亚群体层面协调的代谢和免疫重编程。总体而言，这项工作建立了一种针对细胞器靶向mRNA的神经刺激策略，用于精确调节神经炎症，解决中枢神经系统mRNA递送的关键障碍。
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第6条，共124条
标题: EGFR/ZBED1 reciprocal regulation promotes stemness and tumorigenesis in glioblastoma期刊: NEURO-ONCOLOGY作者: Hou, NN;Wang, YT;You, QX; et al.通讯作者: Zhang, YD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Neurol & Neurosurg, 1 Shuanghu Branch Rd, Chongqing 401120, Peoples R China.; Cui, HJ (通讯作者)，Southwest Univ, State Key Lab Resource Insects, 2 Tiansheng Rd, Chongqing 400715, Peoples R China.文献类型: Article影响因子: 13.4, JCR分区: Q1, 中信所分区: Q1学院: 附三院; 附三院
摘要：胶质母细胞瘤干细胞（GSCs）是胶质母细胞瘤（GBM）内的一种类干肿瘤亚群，表现出显著的自我更新能力和治疗耐药性。锌指BED结构域蛋白1（ZBED1），一种双功能转录因子和SUMO E3连接酶，已被揭示参与恶性肿瘤的致癌过程，其功能作用和调控机制在GSCs中仍然神秘。方法 采用多模态方法，包括免疫组织化学、免疫印迹和免疫荧光，评估GSCs和临床GBM样本中的ZBED1表达模式。功能表征利用体外模型（增殖分析、肿瘤球形成分析和极限稀释分析），并辅以体内正位异种移植模型。机制性研究整合了RNA测序、无标记蛋白质组学、染色质免疫沉淀（ChIP）、免疫组化和西方印迹法，以确定EGFR/ZBED1调控轴。结果 我们证明ZBED1在GSCs中显著上调，且与不良预后相关。ZBED1的遗传消融显著降低了GSC的增殖和自我更新能力，同时延长了异种移植模型中的存活期。在机制上，EGFR介导的酪氨酸残基Y160/Y513上的ZBED1磷酸化增强了ZBED1-UBC9的相互作用，促进了SUMOylation依赖的蛋白质稳定。值得注意的是，ZBED1通过对E3泛素连接酶PARK2的转录抑制，相互维持EGFR表达，建立了对GSC维持至关重要的自我强化EGFR/ZBED1/PARK2信号回路。结论 我们的发现阐明了一种新的EGFR/ZBED1正反馈回路，该回路驱动GSC的传播和肿瘤发生，凸显了ZBED1作为GBM治疗靶向的有吸引力的候选。
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第7条，共124条
标题: Hyaluronic acid-modified CuS nanocages for MRSA-infected wound therapy: Mechanistic insights into size effect期刊: CHEMICAL ENGINEERING JOURNAL作者: Meng, XL;Wu, SY;Wu, JL; et al.通讯作者: Zhang, P (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China.; Wang, Y (通讯作者)，Chongqing Normal Univ, Coll Chem & Mat Sci, Chongqing Key Lab Green Catalysis Mat & Technol, Chongqing 401331, Peoples R China.文献类型: Article影响因子: 13.2, JCR分区: Q1, 中信所分区: Q1学院: 药学院; 药学院
摘要：纳米抗菌剂对抗耐药细菌展现出巨大希望。然而，纳米颗粒大小对杀菌效果的影响仍不充分。阐明这一机制对于优化治疗效果和解决耐药性至关重要。本研究中，我们合成了三种不同尺寸的透明质酸官能化铜硫化纳米笼（HA-CuS NCs）（201.2 +/- 0.5 nm、107.5 +/- 0.3 nm和61.9 +/- 0.6 nm）。在808纳米激光照射10分钟下，HA-CuS NCs通过光热疗法（PTT）、光动力疗法（PDT）和铜离子释放实现了协同杀菌效果。值得注意的是，最小的CuS NCs在体外和体内表现出最低杀菌浓度和优异的抗菌活性，这归因于其活性氧物种生成增强和Cu（II）/Cu（I）比值更高的。令人惊讶的是，纳米颗粒尺寸对其光热转化效率的影响微乎其微。近红外光激活的HA-CuS自然抗电表现出优异的生物安全、高效的广谱抗菌活性以及加速伤口愈合。在MRSA感染的伤口模型中，最小的CuS无损在治疗9天后显著优于临床使用的万古霉素（相对伤口面积比：4.4% vs. 49.1%，t = 6.547，P < 0.05，Cohen's d = 5.346）。本研究为基于尺寸效应的纳米抗菌药物合理设计和优化提供了关键指导。
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第8条，共124条
标题: Rational design of CRISPR-Cas12a crRNAs for enhanced allelic discrimination and low-abundance variant detection期刊: CHEMICAL ENGINEERING JOURNAL作者: Wu, W;Gong, YJ;Deng, MJ; et al.通讯作者: Xie, GM; Li, JJ (通讯作者)，Chongqing Med Univ, Coll Lab Med, Chongqing Med Lab Microfluid & SPRi Engn Res Ctr, Key Lab Clin Lab Diagnost,Chinese Minist Educ, Chongqing 400016, Peoples R China.; Yang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China.; Chen, XP (通讯作者)，Chongqing Med Univ, Ctr Clin Mol Med Detect, Affiliated Hosp 1, Innovat & Translat Lab Mol Diagnost,Lab Med Ctr, Chongqing 400016, Peoples R China.; Xie, GM; Li, JJ (通讯作者)，Western Inst Digital Intelligent Med, Chongqing Natl Biomed Ind Pk, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 13.2, JCR分区: Q1, 中信所分区: Q1学院: 检验医学院; 检验医学院, 附一院
摘要：单核苷酸变异体（SNV）的准确检测对于精确诊断至关重要，但通常受限于序列环境、靶向外激活和放大引起的噪声。CRISPR-Cas虽然高度可编程，但受限于PAM要求和序列依赖性。本文介绍了一个可编程框架，利用CRISPR-Cas12a进行超灵敏SNV检测，整合突变引导crRNA设计（M-crRNA）、分裂靶crRNA（S-crRNA）及PfAgo介导的可编程切割。M-crRNA筛选识别中心敏感位置以最大化错配排斥，而S-crRNA则缩小识别窗口以排除非靶点变异，实现更优异的特异性。PfAgo生成与S-crRNA兼容的靶向分裂激活剂，实现单管扩增-切割整合，保持线性。我们还进一步证明，PCR聚合酶保真度对检测准确性产生关键影响：高保真扩增确保线性定量读数，而低保真聚合酶会扭曲信号并增加假阳性。这两个平台均检测到0.01%等位基因频率的变异，并在26个临床组织样本中实现与下一代测序100%一致，其中包括EGFR L858R阳性NSCLC病例。总体而言，这项工作建立了一个稳健、可推广且临床上可转化的高度灵敏和特异性SNV检测框架，对分子诊断和精准肿瘤学具有广泛意义。
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第9条，共124条
标题: Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis期刊: NUCLEIC ACIDS RESEARCH作者: Yu, S;Zeng, XY;Chen, J; et al.通讯作者: Zhu, Y (通讯作者)，Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China.; Wang, F; Wang, XS (通讯作者)，Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll,Dept Biochem & Mol Biol, Sch Basic Med,State Key Lab Med Mol Biol, Beijing 100005, Peoples R China.; Wang, F; Wang, XS (通讯作者)，Chinese Acad Med Sci, Key Lab RNA & Hematopoiet Regulat, Beijing 100005, Peoples R China.; Zhu, Y (通讯作者)，Chongqing Med Univ, Ctr Med Epigenet, Sch Basic Med Sci, Chongqing 400016, Peoples R China.; Yi, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 13.1, JCR分区: Q1, 中信所分区: Q1学院: 基础医学院; 基础医学院, 附一院
摘要：红细胞生成需要精确协调转录及共转录/后转录程序，但替代多腺苷酸化（APA）在此过程中的作用仍不充分。本研究中，我们利用单细胞RNA测序（scRNA-seq）分析了红细胞生成过程中全基因组动态APA景观。通过聚类和功能富集分析，识别出七种不同的APA动态模式，其中基因表现出阶段特异性APA变化，并在红细胞谱系分化、血红素合成和铁代谢中富集。结合多腺苷酸化位点（PASs）附近的基序分析和APA调控因子表达剖析，我们观察到关键的APA调控因子——切割和多腺苷酸化特异性因子6（CPSF6）表现出显著变异。功能性检测显示，CPSF6促进红细胞生成，因其耗竭会损害血红素合成和细胞内铁缺乏。从机制上看，CPSF6的耗竭缩短了铁代谢调控因子（FAM210B、IREB2、TFRC）的3' UTR长度，同时伴随着这些基因表达的降低。临床上，CPSF6及这些APA调控的铁代谢相关基因在真红细胞增多症（PV）患者中异常上调，与红细胞增生相关。总体而言，我们的研究支持CPSF6-APA铁稳态轴作为红血球生成中重要的共转录调控机制，并指出其失调与PV的发病机制有关，为治疗骨髓增生性肿瘤提供了新的分子靶点。
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第10条，共124条
标题: DNA methyltransferase inhibition is a therapeutic vulnerability in VHL-deficient renal cell carcinoma cells期刊: EXPERIMENTAL AND MOLECULAR MEDICINE作者: Pu, Y;Wang, ZRY;Tao, SS; et al.通讯作者: Shim, JS (通讯作者)，Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa, Peoples R China.; Dang, YJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Basic Med Res & Innovat Ctr Novel Target & Therape, Minist Educ,Coll Pharm, Chongqing, Peoples R China.; Wang, JF (通讯作者)，Shanghai Jiao Tong Univ, Renji Hosp, Dept Urol, Shanghai, Peoples R China.; Shim, JS (通讯作者)，Univ Macau, Frontiers Sci Ctr Precis Oncol, Minist Educ, Taipa, Peoples R China.文献类型: Article; Early Access影响因子: 12.9, JCR分区: Q1, 中信所分区: Q1学院: 药学院
摘要：冯·希佩尔-林道（VHL）是一种肿瘤抑制剂，在肾细胞癌（RCC）中常被失活，其丧失与异常DNA甲基化有关。我们证明了缺乏VHL的RCC细胞对DNA甲基转移酶（DNMT）抑制剂极为敏感。美国食品药品监督管理局批准的DNMT抑制剂，如decitabine和azacitidine，以及RX-3117和SGI-1027等试验药物，选择性抑制了VHL缺失RCC细胞的生长。机制上，VHL的丧失导致HIF-2α依赖性转录上调DNMT1，导致广泛的CpG高甲基化。转录组谱分析和基于RNA干扰的救援筛查确认了KCNK3，一种疑似的肿瘤抑制因子，是VHL缺失RCC中DNMT抑制剂诱导合成致死性的关键介导因子。在VHL缺失的RCC中，KCNK3启动子被高甲基化并被转录抑制，使用DNMT抑制剂可逆转该甲基化，恢复KCNK3表达并导致细胞生长抑制。沉默KCNK3显著减弱了DNMT抑制剂在体外和体内的抗肿瘤效果。进一步的机制分析显示，KCNK3的再激活会触发TNF-α、MAPK和凋亡信号通路，促进观察到的合成致死性。综合来看，这些发现确立了DNMT抑制作为VHL缺失RCC中合成致死策略的存在，并凸显了个性化治疗方法的潜在治疗脆弱性。
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第11条，共124条
标题: An osteoimmunomodulatory microneedle patch targeting ER-mitochondria calcium crosstalk for periodontal tissue regeneration期刊: JOURNAL OF CONTROLLED RELEASE作者: Li, JD;Xiao, QY;Cai, WJ; et al.通讯作者: Gao, X; Song, JL (通讯作者)，426 Songshi North Rd, Chongqing, Peoples R China.文献类型: Article影响因子: 11.5, JCR分区: Q1, 中信所分区: Q1学院: 附属口腔医院
摘要：牙周组织缺损的功能重建仍是临床挑战，主要因持续的促炎反应。内质网应激（ERS）和线粒体功能障碍已被确认是驱动巨噬细胞促炎激活的关键调控因子，但其病理关联尚不明确。本研究通过转录组分析显示，ERS与线粒体功能障碍通过细胞内Ca2+转运失调相互强化。为针对这一机制，我们利用多多巴胺的金属离子螯合特性，设计了双功能多多巴胺纳米颗粒（PDAB NPs），以清除过量的Ca2+，同时加载成骨肽骨形态发生蛋白9（BMP9）以增强促骨生成活性。考虑到牙周组织的解剖限制阻碍新药递送，我们战略性地构建了一种骨免疫调节微针（OIMN），集成了去细胞化细胞外基质（dECM）以实现局部PDAB非注射器的递送。结果表明，OIMN不仅恢复了ERS和线粒体稳态，还重塑了巨噬细胞极化，从而减轻了牙周炎症。此外，改善的骨免疫微环境进一步促进了骨间充质干细胞（BMSC）的骨生成分化和牙周骨再生加速。总体而言，本研究通过调控内质网-线粒体Ca2+的交互作用，提出了一种针对牙周炎的新治疗策略，并建立了治疗其他炎症性骨疾病的转化范式。
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第12条，共124条
标题: Electric field-accelerated allosteric DNA-driven immune reaction for highly rapid and sensitive electrochemiluminescence detection of cMyBP-C protein期刊: BIOSENSORS & BIOELECTRONICS作者: Li, JL;Han, Y;Chen, XR; et al.通讯作者: Chen, YQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China.; Yuan, R (通讯作者)，Southwest Univ, Coll Chem & Chem Engn, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China.文献类型: Article影响因子: 10.5, JCR分区: Q1, 中信所分区: Q1学院: 附二院; 附二院
摘要：构建了超高速且灵敏的电化学发光（ECL）生物传感器，通过电场效应下的变构DNA调控免疫反应，高度特异性地检测急性心肌梗死相关的心脏肌球蛋白结合蛋白C（cMyBP-C）。与传统的低特异性夹心免疫测定相比，变构DNA免疫测定系统避免了免疫交叉反应，即靶蛋白特异性结合两个抗体触发远处DNA构象变化。此外，通过调节热力学稳定性，有助于调整环间区域长度，从而提升目标识别效率。同时，电场加速使变构DNA系统的免疫反应时间从1小时显著缩短至2分钟，提升了急性心肌梗死的诊断效率。该传感平台实现了对cMyBP-C的准确且灵敏的检测，动态范围从100 fg/mL到10 ng/mL，检测极限（LOD）为28.9 fg/mL。ECL生物传感器还被应用于分析80份人体实际血浆样本，表现出卓越的临床表现，包括卓越的灵敏度、准确性和可信度。因此，这种新型蛋白质检测策略在临床诊断中展现出有前景的潜力。
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第13条，共124条
标题: Intense18F-FDG Activity of Aneurysmal Bone Cyst期刊: CLINICAL NUCLEAR MEDICINE作者: Shu, QQ;Feng, Y;Sun, GJ; et al.通讯作者: Cai, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Nucl Med, 74 Linjiang Rd, Chongqing 400010, Peoples R China.文献类型: Editorial Material影响因子: 9.6, JCR分区: Q1, 中信所分区: Q1学院: 附二院; 附二院
摘要：一名20岁男子因颈部疼痛被送入我们医院。增强CT显示C5椎骨后部存在异质增强肿块。在F-18-FDG PET/CT中，该单一病变FDG摄取显著，SUVmax为7.61。患者接受了后方手术进入，切除位于C5的骨病变。术后病理检查显示有动脉瘤性骨囊肿。我们的案例表明动脉瘤性骨囊肿可能表现出强烈的F-18-FDG摄取。因此，对于具有显著FDG敏感度的单发椎体病变，应将动脉瘤骨囊肿纳入鉴别诊断。
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标题: Schisandrin B alleviates liver allograft rejection by stabilizing ACOD1 in Kupffer cells to potentiate itaconate-NRF2-mediated suppression of CD8+T cell chemotaxis期刊: PHYTOMEDICINE作者: Wang, YH;Peng, DD;Lei, DL; et al.通讯作者: Yu, C (通讯作者)，Guizhou Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Guiyang 550001, Guizhou, Peoples R China.; Chen, TX (通讯作者)，Guizhou Med Univ, Sch Basic Med Sci, Dept Physiol, Guiyang 550009, Guizhou, Peoples R China.; Chen, TX (通讯作者)，Guizhou Med Univ, Affiliated Hosp, Guizhou Inst Precis Med, Guiyang 550009, Guizhou, Peoples R China.; Wu, ZJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China.; Chen, TX (通讯作者)，Guizhou Med Univ, Engn Res Ctr Chron Dis Diag & Treatment, Sch Basic Med, Guiyang 550009, Guizhou, Peoples R China.文献类型: Article影响因子: 8.3, JCR分区: Q1, 中信所分区: Q1学院: 附一院
摘要：引言：预防急性排斥反应对于实现肝移植后持久生存至关重要。目前免疫抑制剂受限于毒性和突破性排斥，凸显了新治疗方法的紧迫需求。目的：本研究旨在评估分裂剂B（SchB）在减弱肝脏异体移植物排斥反应中的治疗潜力。方法：采用异基因正位肝移植大鼠模型（刘易斯转BN）。SchB的效果通过功能、组织学和生化评估进行了评估。通过多组学分析、分子生物学方法和体外实验，包括原版Kupffer细胞（KC）-T细胞共培养系统，获得了机制性见解。结果：SchB治疗显著延长异体移植物的存活期，减轻肝损伤，并减少CD8*T细胞的浸润。多组学分析和功能测定显示，SchB显著上调KCs中的免疫代谢物斜锥酸盐。对肌锥酸合成关键酶Acod1的KC特异性敲低，消除了SchB的保护作用，补充肉干酸衍生物4-OI后SchB得以恢复。在机制上，SchB直接结合ACOD1，破坏其与新发现的E3泛素连接酶NEDD4的相互作用，从而抑制K48相关泛素化及随后蛋白酶体降解。积累的意大利锥酸盐激活NRF2，缓解氧化应激并抑制T细胞化学诱导物CXCL10的表达，最终降低CD8*T细胞的招募。结论：本研究揭示了SchB稳定KCs中ACOD1以增强蛋白酸-NRF2信号的新机制，抑制CXCL10介导的CD8*T细胞趋化并缓解排斥反应，使SchB成为肝脏异体排斥的有前景免疫代谢因子。
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标题: Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs-Macrophage Crosstalk期刊: ACS NANO作者: Chen, Y;Lei, RJ;Guo, Q; et al.通讯作者: Li, YZ; He, P; Yang, S (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China.; Li, YZ; He, P; Yang, S (通讯作者)，Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing 401147, Peoples R China.; Li, YZ; He, P; Yang, S (通讯作者)，Chongqing Key Lab Oral Dis, Chongqing 401147, Peoples R China.; Li, YZ; He, P; Yang, S (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China.文献类型: Article; Early Access影响因子: 16.1, JCR分区: Q1, 中信所分区: Q2学院: 附属口腔医院
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标题: Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization期刊: ADVANCED SCIENCE作者: Luo, SH;Lou, FZ;Yang, PR; et al.通讯作者: Jin, X (通讯作者)，Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing, Peoples R China.; Jin, X (通讯作者)，Chongqing Key Lab Oral Dis, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 14.1, JCR分区: Q1, 中信所分区: Q2学院: 附属口腔医院; 附属口腔医院
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标题: Cytoskeletal remodeling promotes tunneling nanotube formation and drives cardiac resident cell mitochondrial transfer in sepsis期刊: SCIENCE ADVANCES作者: Song, R;Huang, C;Ma, YR; et al.通讯作者: Conde, J; Duan, CY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Crit Care Med & Anesthesiol, Chongqing 400010, Peoples R China.; Conde, J (通讯作者)，Univ NOVA Lisboa, Fac Ciencias Med, Comprehens Hlth Res Ctr, NOVA Med Sch,NMS FCM, Lisbon, Portugal.文献类型: Article影响因子: 12.5, JCR分区: Q1, 中信所分区: Q2学院: 附二院; 附二院
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标题: Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8+ T cells期刊: JOURNAL FOR IMMUNOTHERAPY OF CANCER作者: Yang, Y;He, JJ;Liang, TX; et al.通讯作者: Ye, LL (通讯作者)，Southern Med Univ, Sch Lab Med & Biotechnol, Guangdong Prov Key Lab Immune Regulat & Immunother, Guangzhou, Guangdong, Peoples R China.; Ye, LL (通讯作者)，Third Mil Med Univ, Inst Immunol, Chongqing, Peoples R China.; Li, TM (通讯作者)，Third Mil Med Univ, Xinqiao Hosp, Dept Gen Surg, Chongqing, Peoples R China.; Yue, S (通讯作者)，Third Mil Med Univ, Daping Hosp, Canc Ctr, Chongqing, Peoples R China.; Yue, S (通讯作者)，Third Mil Med Univ, Army Med Ctr PLA, Chongqing, Peoples R China.; Chen, XY (通讯作者)，Chongqing Med Univ, Ctr Immune Ageing & Rejuvenat, Dept Rheumatol & Immunol, Affiliated Hosp 1, Chongqing, Peoples R China.文献类型: Article影响因子: 10.6, JCR分区: Q1, 中信所分区: Q2学院: 附一院
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标题: Diagnosis of Major Depressive Disorder With High Suicide Risk Using Slow-Wave Sleep Electroencephalograms by TCFM-CNN期刊: IEEE TRANSACTIONS ON AFFECTIVE COMPUTING作者: Wei, J;Zhang, HY;Penzel, T; et al.通讯作者: Zhang, Y (通讯作者)，Southwest Univ, Coll Elect & Informat Engn, Chongqing 400715, Peoples R China.; Zhang, Y (通讯作者)，Southwest Univ, Yibin Acad, Yibin 644005, Peoples R China.; Qiu, HT (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Qiu, HT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat,Psychiat Ctr, Key Lab Major Brain Dis & Aging Res,Minist Educ, Chongqing 400014, Peoples R China.文献类型: Article影响因子: 9.8, JCR分区: Q1, 中信所分区: Q2学院: 附一院
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标题: The Application of 3D Printing in Cardiac Patch Manufacture期刊: ADVANCED HEALTHCARE MATERIALS作者: Shen, DL;Wang, YL;Zhou, XY; et al.通讯作者: Zhao, MM (通讯作者)，Chongqing Med Univ, Ctr Med Epigenet, Sch Basic Med Sci, Chongqing, Peoples R China.; Zhao, CZ (通讯作者)，Chongqing Med Univ, Lab Skeletal Dev & Regenerat, Key Lab Clin, Lab Diagnost,Coll Lab Med,Minist Educ, Chongqing, Peoples R China.文献类型: Review; Early Access影响因子: 9.6, JCR分区: Q1, 中信所分区: Q2学院: 基础医学院; 基础医学院, 检验医学院
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标题: Ligand-Activated Fluorescent Probe Reveals Mitochondrial Long-Chain Saturated Fatty Acid Flux: An Effective Tool for Metabolic Disorder Studies期刊: SMALL METHODS作者: Lan, TL;Zhao, YF;Zhang, N; et al.通讯作者: Chen, YX; Ruan, XZ (通讯作者)，Chongqing Med Univ, Ctr Lipid Res, Chongqing, Peoples R China.; Chen, YX; Ruan, XZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2,Minist Educ, Inst Viral Hepatitis,Key Lab Mol Biol Infect Dis, Dept Infect Dis,Chongqing Key Lab Metab Lipid & Gl, Chongqing, Peoples R China.; Ruan, XZ (通讯作者)，UCL, Med Sch, Ctr Nephrol, John Moorhead Res Lab, London, England.文献类型: Article; Early Access影响因子: 9.1, JCR分区: Q1, 中信所分区: Q2学院: 附二院; 附二院
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标题: The Effect of Multifunctional Wet Adhesive Hydrogels on the Repair of Full-Thickness Oral Mucosal Defects期刊: ACS APPLIED MATERIALS & INTERFACES作者: Du, WT;Yu, L;Liu, YY; et al.通讯作者: Wu, XH (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing Municipal Hlth Commiss Key Lab Oral Biom, Chongqing Key Lab Oral Dis,Affiliated Stomatol Hos, Chongqing 401147, Peoples R China.文献类型: Article; Early Access影响因子: 8.2, JCR分区: Q1, 中信所分区: Q2学院: 附属口腔医院
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标题: Cationic nanoparticles-enabled mouthwash combats precancerous oral mucosal inflammation期刊: REGENERATIVE BIOMATERIALS作者: Du, MJ;Wang, KY;Ning, QX; et al.通讯作者: Shao, D (通讯作者)，Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China.; Huang, HY; Shao, D; Li, Y; Leong, KW (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Sichuan, Peoples R China.; Huang, HY; Leong, KW (通讯作者)，Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.; Li, Y (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing Municipal Hlth Commiss Key Lab Oral Biom, Chongqing Key Lab Oral Dis,Affiliated Stomatol Hos, Chongqing 404100, Peoples R China.; Leong, KW (通讯作者)，Columbia Univ, Med Ctr, Dept Syst Biol, New York, NY 10032 USA.文献类型: Article影响因子: 8.1, JCR分区: Q1, 中信所分区: Q2学院: 附属口腔医院
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标题: Integrated bulk and single-cell RNA sequencing reveals peripheral immune dysregulation in adolescent major depressive disorder期刊: BRAIN BEHAVIOR AND IMMUNITY作者: Liu, XE;Huang, F;He, YQ; et al.通讯作者: Zhou, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Guo, K (通讯作者)，Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.文献类型: Article影响因子: 7.6, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院
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标题: Retinoblastoma: unveiling molecular pathogenesis and pioneering organoid-driven therapeutic innovations期刊: STEM CELL RESEARCH & THERAPY作者: Li, H; Jin, CR通讯作者: Li, H (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Yongchuan Hosp, Chongqing 402160, Peoples R China.文献类型: Review影响因子: 7.3, JCR分区: Q1, 中信所分区: Q2学院: 附属永川医院; 附属永川医院
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标题: Inhalation of mesenchymal stromal cell-derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia - reperfusion injury期刊: STEM CELL RESEARCH & THERAPY作者: Wang, T;Wu, GD;Gao, PG; et al.通讯作者: Wu, JQ; Zhao, DP (通讯作者)，Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai, Peoples R China.; Wu, JQ; Zhao, DP (通讯作者)，Shanghai Engn Res Ctr Lung Transplantat, Shanghai, Peoples R China.; Li, CW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Chongqing, Peoples R China.文献类型: Article影响因子: 7.3, JCR分区: Q1, 中信所分区: Q2学院: 附一院
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标题: Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan-East Asian crossroads期刊: JOURNAL OF GENETICS AND GENOMICS作者: Wang, MG;Duan, SH;Sun, QX; et al.通讯作者: Tang, RK (通讯作者)，Chongqing Med Univ, Coll Basic Med, Dept Forens Med, Chongqing 400331, Peoples R China.; He, GL (通讯作者)，Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610000, Sichuan, Peoples R China.; Yun, LB (通讯作者)，Sichuan Univ, Ctr Archaeol Sci, Chengdu 610000, Sichuan, Peoples R China.; Yun, LB (通讯作者)，Sichuan Univ, West China Sch Basic Sci & Forens Med, Chengdu 610041, Sichuan, Peoples R China.; Liu, C (通讯作者)，Antidrug Technol Ctr Guangdong Prov, Guangzhou 510230, Guangdong, Peoples R China.文献类型: Article影响因子: 7.1, JCR分区: Q1, 中信所分区: Q2学院: 基础医学院; 基础医学院
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标题: Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation期刊: NEUROTHERAPEUTICS作者: Ke, ZJ;Zhang, Y;Jiang, X; et al.通讯作者: Luo, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 6.9, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院
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标题: Blood-brain barrier penetration determines link between beta blockers and reduced mortality in patients with sepsis-associated encephalopathy: A multicenter cohort study and an effect heterogeneity tool期刊: NEUROTHERAPEUTICS作者: Wang, K;Xia, MS;Long, YX; et al.通讯作者: Yin, YH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Neuromodulat Res & Treatment Ctr, Dept Cardiol,Chongqing Key Lab Arrhythmias, Chongqing 402160, Peoples R China.文献类型: Article影响因子: 6.9, JCR分区: Q1, 中信所分区: Q2学院: 附二院; 附二院
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标题: Salidroside ameliorates experimental autoimmune neuritis by dually modulating neuroinflammation and immune homeostasis via PI3K/ AKT signaling期刊: NEUROTHERAPEUTICS作者: Gu, T;Wang, L;Kang, X; et al.通讯作者: Wang, GW (通讯作者)，NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing 400016, Peoples R China.; Wang, GW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Wang, ZH (通讯作者)，Ningxia Med Univ, Gen Hosp, Inst Med Sci, Yinchuan 750004, Peoples R China.; Wang, ZH (通讯作者)，Diag & Treatment Engn Technol Res Ctr Nervous Syst, Yinchuan 750004, Peoples R China.; Wang, ZH (通讯作者)，Ningxia Med Univ, Neurol Ctr, Gen Hosp, Yinchuan 750004, Peoples R China.文献类型: Article影响因子: 6.9, JCR分区: Q1, 中信所分区: Q2学院: 附一院
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标题: PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis期刊: CELLULAR AND MOLECULAR LIFE SCIENCES作者: Guo, JS;Lin, Y;Gong, X; et al.通讯作者: Wan, JY; Wang, T (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 2, Chongqing, Peoples R China.; Wan, JY (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China.; Zhang, L (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing, Peoples R China.文献类型: Article影响因子: 6.2, JCR分区: Q1, 中信所分区: Q2学院: 附二院; 附二院, 药学院
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标题: The Global Reading Room: A Patient With Rectal Gas Artifact on Prostate MRI期刊: AMERICAN JOURNAL OF ROENTGENOLOGY作者: He, XJ;Pausch, AM;Platzek, I; et al.通讯作者: Pausch, AM (通讯作者)，Univ Hosp Zurich, Diagnost & Intervent Radiol, Zurich, Switzerland.文献类型: Editorial Material影响因子: 6.1, JCR分区: Q1, 中信所分区: Q2学院: 附二院
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标题: Development of EL/PLGA nanoparticles for oral delivery of methotrexate with enhanced bioavailability and reduced toxicity期刊: DRUG DELIVERY AND TRANSLATIONAL RESEARCH作者: Wu, XW;Zhang, QY;Zeng, XL; et al.通讯作者: Chen, HL (通讯作者)，Chongqing Med Univ, Coll Pharm, Pharmaceut Preparat & Nanomed Technol Res Ctr, Med Sch Rd, Yuzhong Dist, Chongqing 400042, Peoples R China.文献类型: Article; Early Access影响因子: 5.5, JCR分区: Q1, 中信所分区: Q2学院: 药学院; 药学院
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标题: Analyzing the role of GNG4 molecular mechanism in neuroendocrine differentiation process through electrochemical sensors: biomarker diagnosis of prostate cancer期刊: MICROCHEMICAL JOURNAL作者: Li, YF;Han, K;He, JK; et al.通讯作者: Wei, CC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China.; Su, S (通讯作者)，Army Med Univ, Third Mil Med Univ, Xinqiao Hosp, Urol Surg Ctr,Dept Urol, Chongqing 400037, Peoples R China.文献类型: Article影响因子: 5.1, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院
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标题: HSDL2 Suppresses Epileptic Seizures Through Phosphorylation-Dependent Modulation of the PSD95-NMDAR Signaling Axis期刊: CNS NEUROSCIENCE & THERAPEUTICS作者: Xia, Y;Jing, W;Hui, Z; et al.通讯作者: Demei, X; Liang, W (通讯作者)，Chongqing Med Univ, Dept Neurol, Chongqing Key Lab Major Neurol & Mental Disorders, Chongqing Key Lab Neurol,Affiliated Hosp 1, Chongqing, Peoples R China.; Xi, P (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 2, Chongqing, Peoples R China.; Liang, W (通讯作者)，Chongqing Med Univ, Key Lab Major Brain Dis & Aging Res, Minist Educ, Chongqing, Peoples R China.文献类型: Article影响因子: 5, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院, 附二院
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标题: Sequenced treatment alternatives to relieve adolescent depression: A pragmatic clinical trial期刊: JOURNAL OF AFFECTIVE DISORDERS作者: He, YQ;Xian, Y;Li, XM; et al.通讯作者: Liu, XE; Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China.文献类型: Article影响因子: 4.9, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院
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标题: IR-780 improves urination function and complications in rats with partial bladder outlet obstruction by protecting bladder smooth muscle cell mitochondria from oxidative stress期刊: FRONTIERS IN PHARMACOLOGY作者: Pi, F;Yan, BH;Jia, M; et al.通讯作者: Fang, Q; Li, WB (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Urol, Chongqing, Peoples R China.文献类型: Article影响因子: 4.8, JCR分区: Q1, 中信所分区: Q2学院: 附三院; 附三院
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标题: Epithelial-mesenchymal transition and sunitinib resistance in renal cell carcinoma: mechanisms and therapeutic strategies期刊: FRONTIERS IN PHARMACOLOGY作者: Zhang, MK;Zhang, YR;Shen, F; et al.通讯作者: Li, W (通讯作者)，Chongqing Med Univ, Ctr Med Epigenet, Sch Basic Med Sci, Chongqing, Peoples R China.文献类型: Review影响因子: 4.8, JCR分区: Q1, 中信所分区: Q2学院: 国际医学院; 基础医学院
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标题: Adenosine A2A receptors regulate D2-type medium spiny neurons in the nucleus accumbens to mediate pain and depression comorbidity期刊: FRONTIERS IN PHARMACOLOGY作者: Zhou, DY;Yang, XA;Song, LZ; et al.通讯作者: Min, S (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China.; Cao, JL (通讯作者)，Nanjing Med Univ, Nanjing, Peoples R China.文献类型: Article影响因子: 4.8, JCR分区: Q1, 中信所分区: Q2学院: 附一院; 附一院
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标题: Tumor-Educated Extracellular Vesicle-Derived LINC01116 Drives Non-Small Cell Lung Cancer Progression and Immunosuppression by Sponging miR-3614-5p to Upregulate ARHGAP1期刊: INTERNATIONAL IMMUNOPHARMACOLOGY作者: Zhang, HW;Hou, YB;Wang, YJ; et al.通讯作者: Yang, Z (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Yongchuan Hosp, Chongqing 402160, Peoples R China.; Mao, N (通讯作者)，Chongqing Med Univ, Dept Cardiothorac Surg, Affiliated Yongchuan Hosp, Chongqing 402160, Peoples R China.文献类型: Article影响因子: 4.7, JCR分区: Q1, 中信所分区: Q2学院: 附属永川医院; 附属永川医院
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标题: Rab32-mediated macrophage apoptosis and apoptotic body release promote M1 polarization in ARDS via the Cxcl11/Ccl4/NF-κB pathway期刊: INTERNATIONAL IMMUNOPHARMACOLOGY作者: Wu, D;Liu, Q;Zhou, XX; et al.通讯作者: Wang, DX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Chongqing 400010, Peoples R China.; Qian, H (通讯作者)，Army Med Univ, Third Mil Med Univ, Xinqiao Hosp, Dept Pulm & Crit Care Med,Inst Resp Dis, Chongqing 400037, Peoples R China.; He, BF (通讯作者)，Army Med Univ, Third Mil Med Univ, Xinqiao Hosp, Dept Gen Practice, Chongqing 400037, Peoples R China.文献类型: Article影响因子: 4.7, JCR分区: Q1, 中信所分区: Q2学院: 附二院; 附二院
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标题: Letter to the Editor: A deep learning framework to stratify Nottingham histologic grade 2 breast tumors based on dynamic contrast-enhanced MRI期刊: EUROPEAN RADIOLOGY作者: Xu, YK;Wang, Y;Gao, S; et al.通讯作者: Liu, SC (通讯作者)，Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 1, Chongqing, Peoples R China.文献类型: Letter; Early Access影响因子: 4.7, JCR分区: Q1, 中信所分区: Q2学院: 附一院
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标题: The Association Between Prepubertal Polycyclic Aromatic Hydrocarbon Exposure and Physical Development During Puberty in Chinese Girls: A Longitudinal Study期刊: EXPOSURE AND HEALTH作者: Li, Y;He, ZW;Zhang, Q; et al.通讯作者: Liu, Q (通讯作者)，Chongqing Med Univ, Res Ctr Environm & Human Hlth, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing, Peoples R China.文献类型: Article影响因子: 4.6, JCR分区: Q1, 中信所分区: Q2学院: 公卫学院; 公卫学院
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标题: Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study期刊: CLINICAL EPIGENETICS作者: Zhang, Z;Wang, XL;Qiu, HT; et al.通讯作者: Jiang, CG (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Sleep & Psychol, Chongqing 401147, Peoples R China.; Jiang, CG (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Sleep & Psychol, Chongqing 401147, Peoples R China.; Jiang, CG (通讯作者)，Chongqing Res Ctr Prevent & Control Maternal & Chi, Chongqing 401147, Peoples R China.; Yang, G (通讯作者)，Xuzhou Med Univ, Lianyungang Hosp, Peoples Hosp Lianyungang 1, Dept Psychosomat Med, Lianyungang 222000, Jiangsu, Peoples R China.; Yang, G (通讯作者)，Nanjing Med Univ, Affiliated Hosp 1, Peoples Hosp Lianyungang 1, Kangda Coll,Dept Psychosomat Med, Lianyungang 222000, Jiangsu, Peoples R China.文献类型: Article影响因子: 4.4, JCR分区: Q1, 中信所分区: Q2学院: 妇幼保健院
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标题: Effectiveness of escape room in Chinese nursing education: a systematic review and meta-analysis期刊: BMC NURSING作者: Yang, M;Zhu, L;Zhang, ZJ; et al.通讯作者: Xu, QG (通讯作者)，Chongqing Med Univ, Sch Pharm, Chongqing, Peoples R China.文献类型: Review影响因子: 3.9, JCR分区: Q1, 中信所分区: Q2学院: 药学院
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标题: Bilateral intralobar and extralobar pulmonary sequestration in an infant with severe pectus excavatum期刊: ASIAN JOURNAL OF SURGERY作者: Han, Z;Li, HB;Lv, PJ; et al.通讯作者: Li, HB (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Chongqing 401122, Peoples R China.文献类型: Letter影响因子: 3.8, JCR分区: Q1, 中信所分区: Q2学院: 附属儿童医院; 附属儿童医院
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标题: Correlation of early blood lactate clearance with short- and mid-term outcomes in patients with septic shock期刊: ASIAN JOURNAL OF SURGERY作者: Song, J; Liu, CC; Gong, MW通讯作者: Gong, MW (通讯作者)，Chongqing Med Univ, Dept Crit Care Med, Affiliated Hosp 3, Chongqing, Peoples R China.文献类型: Letter影响因子: 3.8, JCR分区: Q1, 中信所分区: Q2学院: 附三院; 附三院
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标题: The impact of structured educational intervention on elderly patients with Type 2 diabetes期刊: ASIAN JOURNAL OF SURGERY作者: Zhou, JH; Jiang, ML; Zeng, Y通讯作者: Zeng, Y (通讯作者)，Chongqing Med Univ, Chongqing Peoples Hosp 9, Dept Endocrinol, Affiliated Beibei Hosp, 1,Yueya Village, Chongqing, Peoples R China.文献类型: Letter影响因子: 3.8, JCR分区: Q1, 中信所分区: Q2学院: 附属北碚医院; 附属北碚医院
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标题: ACOT11 as a novel biomarker and therapeutic target in lung squamous cell carcinoma期刊: ASIAN JOURNAL OF SURGERY作者: Liu, CH;Wang, YZ;Tang, MZ; et al.通讯作者: Zhang, Y (通讯作者)，Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing 400010, Peoples R China.文献类型: Letter影响因子: 3.8, JCR分区: Q1, 中信所分区: Q2学院: 检验医学院
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标题: Risk factors for mortality in children with pertussis and hyperleukocytosis undergoing exchange transfusion: a single-center retrospective cohort study期刊: ITALIAN JOURNAL OF PEDIATRICS作者: Wu, XY;Yang, RL;Xu, HM; et al.通讯作者: Gan, C (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Child Rare Dis Infect & Immun, Natl Clin Res Ctr Children & Adolescents Hlth & Di, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, 136 Zhongshaner Rd, Chongqing 400014, Peoples R China.文献类型: Article影响因子: 3.1, JCR分区: Q1, 中信所分区: Q2学院: 附属儿童医院; 附属儿童医院
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标题: Exploring factors that affect job crafting behavior among nurses: A qualitative study期刊: NURSING ETHICS作者: Li, JZ;Lao, YQ;Xing, L; et al.通讯作者: Li, JZ (通讯作者)，Chongqing Med Univ, Affiliated Banan Hosp, Chongqing 401320, Peoples R China.; Lao, YQ (通讯作者)，Guilin Med Univ, Affiliated Hosp 1, Guilin 541001, Peoples R China.; Jiang, HC (通讯作者)，Jingdezhen Univ, Sch Informat Engn, Jingdezhen, Jiangxi, Peoples R China.文献类型: Article; Early Access影响因子: 2.7, JCR分区: Q1, 中信所分区: Q2学院: 附属巴南医院; 附属巴南医院
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标题: NOX2 exacerbates periodontitis via JAK2-STAT3-mediated ferroptosis of gingival epithelial cells期刊: FRONTIERS IN IMMUNOLOGY作者: Ping, Y;Wang, ZM;Yang, B; et al.通讯作者: He, YJ (通讯作者)，Chongqing Med Univ, Dept Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China.; Wang, W (通讯作者)，First Affiliated Hosp, Chongqing Med & Pharmaceut Coll, Chongqing, Peoples R China.文献类型: Article影响因子: 5.9, JCR分区: Q1, 中信所分区: Q3学院: 检验医学院; 检验医学院
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标题: Immune-activated & pathology-characterized: the distinct clear cell renal cell carcinoma subtypes for 3PM strategies derived from artificial intelligence in multi-omics期刊: EPMA JOURNAL作者: Zhang, C;Zeng, HJ;Liu, XJ; et al.通讯作者: Xie, B; Zhong, XN (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Yixue Rd, Chongqing 400016, Peoples R China.; Fu, HT (通讯作者)，Hubei Univ, Sch Artificial Intelligence, Wuhan 430062, Peoples R China.文献类型: Article; Early Access影响因子: 5.9, JCR分区: Q1, 中信所分区: Q3学院: 公卫学院; 公卫学院
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标题: Glomerular cell atlas of multi-disease model revealed the characteristic changes of glomerular cell subtypes in diseases期刊: FRONTIERS IN IMMUNOLOGY作者: Huang, Y;Li, S;Li, SY; et al.通讯作者: Chen, QL (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Children & Adolescents Hlth & Di, Dept Nephrol,Chongqing Key Lab Pediat Metab & Infl, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing, Peoples R China.文献类型: Article影响因子: 5.9, JCR分区: Q1, 中信所分区: Q3学院: 附属儿童医院
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标题: Unraveling the Molecular Mechanisms of Benzo(a)pyrene (BaP)-Induced Ovarian-Related Disorders: Integrating Computational Predictions and Experimental Validation期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES作者: Ma, MW;Qi, T;Lin, YQ; et al.通讯作者: Chen, XM (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Toxicol, Chongqing 400016, Peoples R China.; Xu, HT; Chen, XM (通讯作者)，Chongqing Med Univ, Minist Educ, Joint Int Res Lab Reprod & Dev, Chongqing 400016, Peoples R China.; Xu, HT (通讯作者)，Chongqing Med Univ, Sch Basic Med, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 4.9, JCR分区: Q1, 中信所分区: Q3学院: 公卫学院; 公卫学院, 基础医学院
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标题: Leonurine alleviates HFD-induced inflammation and dyslipidemia via modulating gut microbiota-derived indole-3-propionic acid signaling期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY作者: Xi, TL;Jiang, WL;Luo, ZL; et al.通讯作者: Ouyang, J (通讯作者)，Chongqing Publ Hlth Med Ctr, 109 Baoyu Rd, Chongqing 400036, Peoples R China.; Yang, JD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 4.9, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院
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标题: Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES作者: Li, XB;Wang, FX;Liu, NX; et al.通讯作者: Tang, M (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Cardiovasc Res Ctr, Dept Cardiovasc Med, Chongqing 400016, Peoples R China.; Yu, WM (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 4.9, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院, 药学院
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标题: 2016 sJIA-MAS criteria and a step-up therapeutic approach in KD-MAS: insights from a combined cohort and literature review期刊: RMD OPEN作者: Zhao, YH;Tang, ZH;Liu, HX; et al.通讯作者: Yang, X (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Children & AdolescentsHealth & D, Dept Rheumatol & Immunol, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China.; Yang, X (通讯作者)，Chongqing Key Lab Child Rare Dis Infect & Immun, Chongqing, Peoples R China.文献类型: Article影响因子: 4.8, JCR分区: Q1, 中信所分区: Q3学院: 重庆医科大学
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标题: Symptom-level relationships between depressive and anxiety symptoms in rural children and adolescents: A network analysis of gender-specific patterns期刊: ASIAN JOURNAL OF PSYCHIATRY作者: Zhu, HA;Yuan, BW;Qiu, TY; et al.通讯作者: Jiang, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gen Med, Chongqing 400010, Peoples R China.文献类型: Letter影响因子: 4.5, JCR分区: Q1, 中信所分区: Q3学院: 附二院; 附二院
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标题: Imaging features of central nervous system paragonimiasis in children based on a large-scale case series study期刊: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES作者: Qin, Y;Ji, WY;Tian, L; et al.通讯作者: Cai, JH (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Childrens, Dept Radiol,China Int Sci & Technol Cooperat base, Minist Educ Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China.; Chen, X (通讯作者)，Chongqing Med Univ, Dept Outpatient Surg, Childrens Hosp, Chongqing, Peoples R China.文献类型: Article影响因子: 4.3, JCR分区: Q1, 中信所分区: Q3学院: 附属儿童医院; 附属儿童医院
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标题: High palmitate induces ferroptosis in RIN-m5f cells via miR-3584-5p-mediated suppression of AQP7期刊: SCIENTIFIC REPORTS作者: Luan, C;Wang, Z;Li, MJ; et al.通讯作者: Yang, M (通讯作者)，Chongqing Med Univ, Ctr Neurosci, Sch Basic Med Sci, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3.9, JCR分区: Q1, 中信所分区: Q3学院: 基础医学院; 基础医学院
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标题: Comparison of Postoperative Adjuvant CTACE vs DEB-TACE Combined with Tislelizumab and Lenvatinib in BCLC Stage B/C Hepatocellular Carcinoma: A Propensity Score-Matched Analysis of Survival Outcomes期刊: ACADEMIC RADIOLOGY作者: Shi, Y;Yang, LP;Li, XD; et al.通讯作者: Shi, ZR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China.文献类型: Article影响因子: 3.9, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院
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标题: A predictive model for depression in Chinese middle-aged and elderly people with arthritis期刊: BMC PSYCHIATRY作者: Yin, L; Pu, KH; Ke, W通讯作者: Ke, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Emergency, Chongqing 400000, Peoples R China.文献类型: Article影响因子: 3.6, JCR分区: Q1, 中信所分区: Q3学院: 附二院; 附二院
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标题: Foods rich in anti-inflammatory components and anti-inflammatory supplements for the prevention and treatment of Sarcopenia in older adults: A systematic review and network meta-analysis期刊: COMPLEMENTARY THERAPIES IN MEDICINE作者: Li, S;Li, JX;Ren, KK; et al.通讯作者: Zhao, QH; Huang, HH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nursing, Chongqing 400016, Peoples R China.文献类型: Review影响因子: 3.5, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院
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标题: A Laboratory-Adaptive Dynamic Quality Control Framework Reduces Targeted Capture Sequencing Failure in Solid Tumors by >90% A Scalable Solution for Clinical Genomics期刊: JOURNAL OF MOLECULAR DIAGNOSTICS作者: Wu, J;Zhao, J;Wang, XF; et al.通讯作者: Chen, LX; Chen, XP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Ctr Clin Mol Med Detect, Innovat & Translat Lab Mol Diagnost,Lab Med Ctr, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Chen, LX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Cent Lab, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3.4, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院
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标题: The ripple effect of stigmatization on children with congenital hypospadias: impacts on psychological and behavioral aspects期刊: FRONTIERS IN PUBLIC HEALTH作者: Zhang, W; Mo, L; Liu, T通讯作者: Mo, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Children & Adolescents Hlth & Di, Dept Outpatient,Chongqing Key Lab Child Neurodev &, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China.文献类型: Article影响因子: 3.4, JCR分区: Q1, 中信所分区: Q3学院: 附属儿童医院
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标题: Quality and reliability of glaucoma-related online Chinese videos on Douyin and Bilibili: Cross-sectional content analysis study期刊: DIGITAL HEALTH作者: Wang, DD;Pu, YY;Li, YF; et al.通讯作者: Li, H (通讯作者)，Chongqing Med Univ, Chongqing Eye Inst,Chongqing Key Lab Prevent & Tre, Chongqing Branch,Natl Clin Res Ctr Ocular Dis, Dept Ophthalmol,Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3.3, JCR分区: Q1, 中信所分区: Q3学院: 附一院; 附一院
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标题: Safety and user perception of general-purpose large language models in pediatric healthcare: Evaluations of ChatGPT by doctors and parents期刊: DIGITAL HEALTH作者: Tan, J;Wang, L;Wang, GH; et al.通讯作者: Chen, L (通讯作者)，Chongqing Med Univ, Growth Dev & Mental Hlth Ctr Children & Adolescent, Natl Clin Res Ctr Children & AdolescentsHealth & D, Chongqing Key Lab Child Neurodev & Cognit Disorder, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China.文献类型: Article影响因子: 3.3, JCR分区: Q1, 中信所分区: Q3学院: 附属儿童医院; 附属儿童医院
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标题: Evaluating the value of lactic dehydrogenase in anti-MDA5-positive Dermatomyositis associated with interstitial lung disease期刊: FRONTIERS IN MEDICINE作者: Huang, WH;Ren, FF;Qian, KC; et al.通讯作者: Tang, L (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Chongqing, Peoples R China.文献类型: Article影响因子: 3, JCR分区: Q1, 中信所分区: Q3学院: 附二院; 附二院
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标题: The temporal trends of incidence, prevalence, mortality, and disability-adjusted life years of inflammatory bowel disease in the Chinese population aged 0-54 years and prediction to 2030期刊: FRONTIERS IN MEDICINE作者: Jiang, X; Xie, N; Hu, YQ通讯作者: Hu, YQ (通讯作者)，Chongqing Gen Hosp, Chongqing, Peoples R China.; Hu, YQ (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.文献类型: Article影响因子: 3, JCR分区: Q1, 中信所分区: Q3学院: 重庆医科大学
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标题: Adverse events related to drug-drug interactions in tocilizumab combination therapy: a retrospective analysis and clinical implications期刊: FRONTIERS IN MEDICINE作者: Huo, BN;Shu, L;Zhang, Y; et al.通讯作者: Jia, YT; Song, L (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Child Rare Dis Infect & Immun, Natl Clin Res Ctr Child & Adolescents Hlth & Dis,D, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing, Peoples R China.文献类型: Article影响因子: 3, JCR分区: Q1, 中信所分区: Q3学院: 附属儿童医院; 附属儿童医院
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标题: Diabetes Impairs the Virological Response in Patients with Chronic Hepatitis B: Glycemic Control as a Key Modifiable Risk Factor期刊: JOURNAL OF CLINICAL MEDICINE作者: Li, AY;Han, Y;Xiao, GL; et al.通讯作者: He, TY; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Minist Educ,Key Lab Mol Biol Infec, Chongqing 401336, Peoples R China.文献类型: Article影响因子: 2.9, JCR分区: Q1, 中信所分区: Q3学院: 附二院; 附二院
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标题: Pulmonary infection by Nocardia saintgeorgesii mimicking lung cancer with concurrent pulmonary embolism in an immunocompetent host: a case highlighting the diagnostic role of mNGS期刊: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY作者: Hu, H;Cai, DS;Li, J; et al.通讯作者: Wang, KJ (通讯作者)，Chongqing Med Univ, Bishan Hosp, Chongqing, Peoples R China.; Li, J (通讯作者)，Chongqing Liang Jiang New Area Tradit Chinese Med, Chongqing, Peoples R China.文献类型: Article影响因子: 4.8, JCR分区: Q2, 中信所分区: Q3学院: 附属璧山医院; 附属璧山医院
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标题: Characterization of phage AbpL with a terminally redundant genome and its therapeutic potential against drug-resistant Acinetobacter baumannii infections期刊: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY作者: Liu, DF;Zhang, KX;Li, D; et al.通讯作者: Jiang, WW; Qian, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Pharm, Chongqing, Peoples R China.文献类型: Article影响因子: 4.8, JCR分区: Q2, 中信所分区: Q3学院: 附二院; 附二院
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标题: Sodium Danshensu promotes diabetic wound healing by targeting the EGFR-mediated PI3K-AKT pathway: a combined network pharmacology, machine learning, and in vitro approach期刊: RSC ADVANCES作者: Ning, P;Yang, F;Cao, HY; et al.通讯作者: Zhou, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 4.6, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院
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标题: m6A RNA Methylation Promotes the Melanoma Metastasis Mediated by Extracellular Vesicle miR-23a-5p期刊: CANCERS作者: Li, CS;Li, J;Han, X; et al.通讯作者: Chen, M; Huang, GN (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Chongqing Key Lab Human Embryo Engn & Precis Med, Ctr Reprod Med,Women & Childrens Hosp, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 4.4, JCR分区: Q2, 中信所分区: Q3学院: 妇幼保健院
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标题: Dual-Responsive Micelles Co-delivering All-Trans Retinoic Acid and Paclitaxel for Enhanced Eradication of Osteosarcoma Stem Cells期刊: ACS OMEGA作者: Chen, ZY;Chen, JH;Liu, S; et al.通讯作者: Zhang, H (通讯作者)，Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China.; Zhang, Y (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Orthopaed,Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China.; Pu, XL (通讯作者)，Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Peoples R China.文献类型: Article; Early Access影响因子: 4.3, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附属儿童医院
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标题: A PLGA-based aptamer delivery system for modulating subconjunctival fibrosis after glaucoma filtration surgery期刊: BIOMEDICAL MATERIALS作者: Luo, WD;Li, LL;Lin, Y; et al.通讯作者: Xie, L (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 3, Chongqing 401120, Peoples R China.文献类型: Article影响因子: 3.7, JCR分区: Q2, 中信所分区: Q3学院: 附三院; 附三院
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标题: Synthesis and biological evaluation of chitosan-coated ZnO nanoparticles: Impact on fibroblast differentiation, mitochondrial health, and oxidative stress in mouse embryonic fibroblast cells期刊: CHINESE JOURNAL OF CHEMICAL ENGINEERING作者: Ullah, M;Li, HY;Ullah, R; et al.通讯作者: Song, FZ (通讯作者)，Chongqing Med Univ, Mol Med & Canc Res Ctr, Yuzhong 400016, Peoples R China.文献类型: Article影响因子: 3.7, JCR分区: Q2, 中信所分区: Q3学院: 基础医学院; 基础医学院
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标题: SFS-Net: A Method for Medical Image Segmentation Based on Shallow Feature Supplementation and Enhancement期刊: IEEE ACCESS作者: Jiang, Z;Wang, R;Lv, FJ; et al.通讯作者: Zhang, ZW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Yuzhong, Peoples R China.文献类型: Article影响因子: 3.6, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院
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标题: NSUN6-mediated m5C RNA methylation aggravate osteosarcoma progression through promoting PKP2 mRNA stability and expression期刊: BONE作者: Zhao, CY;Tang, Y;He, YP; et al.通讯作者: Fu, KW (通讯作者)，Chongqing Univ, Canc Hosp, Chongqing Key Lab Mech & Intervent Canc Metastasis, 181 Hanyu Road, Chongqing 400030, Peoples R China.; Fu, KW (通讯作者)，Chongqing Canc Inst, 181 Hanyu Road, Chongqing 400030, Peoples R China.; Fu, KW (通讯作者)，Chongqing Canc Hosp, 181 Hanyu Road, Chongqing 400030, Peoples R China.; Yu, ZY (通讯作者)，Chongqing Orthoped Hosp Tradit Chinese Med, Dept Foot & Ankle Surg, Chongqing 400039, Peoples R China.; Yu, ZY (通讯作者)，Peoples Hosp Chongqing Yuzhong Dist, Chongqing 400039, Peoples R China.; Yu, ZY (通讯作者)，Chongqing Inst Orthoped Tradit Chinese Med, Chongqing 400039, Peoples R China.文献类型: Article影响因子: 3.6, JCR分区: Q2, 中信所分区: Q3学院: 重庆医科大学
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标题: A comparative study (2024) on the web impact of institutional repository between the United States, the United Kingdom, India, and China期刊: SCIENTOMETRICS作者: Li, M; Wu, H通讯作者: Wu, H (通讯作者)，Chongqing Med Univ, Sci Res Management Off, Chongqing 400016, Peoples R China.文献类型: Article; Early Access影响因子: 3.5, JCR分区: Q2, 中信所分区: Q3学院: 重庆医科大学
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标题: Transcriptomic analysis of tigecycline-induced colistin collateral sensitivity in carbapenem-resistant Enterobacter cloacae complex期刊: MSPHERE作者: Liang, YT;Wu, JM;Zhang, JS; et al.通讯作者: Gou, XM; Zhang, XL (通讯作者)，Chongqing Med Univ, Affiliated Yongchuan Hosp, Dept Microbiol, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 3.1, JCR分区: Q2, 中信所分区: Q3学院: 附属永川医院; 附属永川医院
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标题: Afebrile Presentation in COPD Patients with Influenza A: A Risk Factor for Prolonged Viral Shedding期刊: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE作者: Fan, YC;Fan, JL;Ma, L; et al.通讯作者: Chen, YJ (通讯作者)，Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3.1, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院
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标题: Serum Raman spectroscopy combined with PCA-CNN model for the diagnosis of hepatitis B, liver cirrhosis, and Hepatocellular Carcinoma期刊: VIBRATIONAL SPECTROSCOPY作者: Wang, BY;Zhang, L;Wu, GH; et al.通讯作者: Mei, T (通讯作者)，Beijing Univ Posts & Telecommun, Sch Sci, Beijing 100876, Peoples R China.; Tang, YS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3.1, JCR分区: Q2, 中信所分区: Q3学院: 附一院
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标题: Multimodal MRI radiomics for predicting HIFU ablation efficacy in uterine fibroids: a machine learning study期刊: INTERNATIONAL JOURNAL OF HYPERTHERMIA作者: Zhou, X;Qiu, YX;Chen, Y; et al.通讯作者: Chen, JY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.; Yang, MJ (通讯作者)，Chongqing Med Univ, Coll Artificial Intelligence Med, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 3, JCR分区: Q2, 中信所分区: Q3学院: 生物医学工程学院; 生物医学工程学院, 人工智能医学学院
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标题: Moderated mediating effects of perceived loneliness and economic burden between social support and mental health for lung cancer patients期刊: SUPPORTIVE CARE IN CANCER作者: Zhang, C;Dan, JY;Sun, XM; et al.通讯作者: Qiu, C (通讯作者)，Sichuan Univ, West China Hosp, West China Sch Med, Chengdu, Sichuan, Peoples R China.; Qiu, C (通讯作者)，Sichuan Univ, West China Sch Nursing, Chengdu, Sichuan, Peoples R China.; Dong, JS (通讯作者)，Sichuan Univ, West China Hosp, Dept Thorac Surg, Chengdu, Sichuan, Peoples R China.; Dong, JS (通讯作者)，Sichuan Univ, West China Hosp, Lung Canc Inst, Lung Canc Ctr, Chengdu, Sichuan, Peoples R China.文献类型: Article影响因子: 3, JCR分区: Q2, 中信所分区: Q3学院: 人工智能医学学院
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标题: Refining the Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing in High-Risk Population of Infection: A Narrative Review期刊: INFECTION AND DRUG RESISTANCE作者: Li, XY;Li, JJ;Zhang, LB; et al.通讯作者: Yang, SS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Review影响因子: 2.9, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院
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标题: Machine learning-based prognostic analysis of patients with status epilepticus in the neurological intensive care unit期刊: JOURNAL OF CRITICAL CARE作者: Qin, NX;Yi, FH;Feng, L; et al.通讯作者: Liang, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China.; Xi, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China.文献类型: Article影响因子: 2.9, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院, 附二院
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标题: A systematic exploration of gut microbiota-driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study期刊: FRONTIERS IN GENETICS作者: Zhang, YH;Qiu, CH;Li, XY; et al.通讯作者: Liu, J; Zhu, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China.文献类型: Article影响因子: 2.8, JCR分区: Q2, 中信所分区: Q3学院: 附二院; 附二院
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标题: Correlation between umbilical cord concentration of the growth hormone-IGF axis and small for gestational age: A single-center retrospective, observational study期刊: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS作者: Wen, J;Zhao, Y;Xian, RL; et al.通讯作者: Fan, X (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Pediat, Women & Childrens Hosp, 120 Longshan Rd, Yubei Dist, Chongqing 401147, Peoples R China.文献类型: Article影响因子: 2.6, JCR分区: Q2, 中信所分区: Q3学院: 妇幼保健院
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标题: Choroid plexus structural and functional abnormalities correlate with disease severity and cognition in cerebral small vessel disease期刊: NEURORADIOLOGY作者: Luo, D;Wang, XH;Peng, YL; et al.通讯作者: Luo, TY; Li, YM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 2.6, JCR分区: Q2, 中信所分区: Q3学院: 附一院; 附一院
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标题: Comparative efficacy and acceptability of non-pharmacological and pharmacological treatments in post-stroke depression: protocol for a systematic review and network meta-analysis期刊: BMJ OPEN作者: Yao, XY;Pu, JC;Fan, Y; et al.通讯作者: Yang, LN (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Key Lab Phys Med & Precis Rehabil, Dept Rehabil Med,Chongqing Municipal Hlth Commiss, Chongqing, Peoples R China.文献类型: Article影响因子: 2.3, JCR分区: Q2, 中信所分区: Q3学院: 附一院
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标题: Linkage between IL-23 and coronary arterial lesions in pediatric patients with Kawasaki disease期刊: FRONTIERS IN PEDIATRICS作者: Wei, Y;Feng, SQ;Wu, JH; et al.通讯作者: Su, Y; Yi, QJ (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Children & AdolescentsHlth & D, Dept Cardiol,Childrens Hosp, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Su, Y; Yi, QJ (通讯作者)，Natl Clin Key Cardiovasc Specialty, Chongqing, Peoples R China.; Su, Y; Yi, QJ (通讯作者)，Chongqing Municipal Hlth Commiss, Key Lab Childrens Vital Organ Dev & Dis, Chongqing, Peoples R China.文献类型: Article影响因子: 2, JCR分区: Q2, 中信所分区: Q3学院: 附属儿童医院; 附属儿童医院
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标题: Mobile cognitive assessment demonstrates diagnostic equivalence to MMSE and MoCA scales in Alzheimer's disease screening期刊: FRONTIERS IN NEUROLOGY作者: Zhang, YZ;Chen, Q;Xie, H; et al.通讯作者: Zhang, M (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Outpatient, Chengdu, Peoples R China.文献类型: Article影响因子: 2.8, JCR分区: Q2, 中信所分区: Q4学院: 附一院
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标题: The effects of perceived social support and psychological capital on attitudes towards professional psychological help-seeking among Chinese college students: The mediating role of psychological help-seeking stigma期刊: PLOS ONE作者: Xie, YY; Yao, LH; Ye, CR通讯作者: Yao, LH (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China.文献类型: Article影响因子: 2.6, JCR分区: Q2, 中信所分区: Q4学院: 公卫学院; 公卫学院
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标题: Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model期刊: AIDS RESEARCH AND THERAPY作者: Zhu, LJ;Yan, JY;Wang, QH; et al.通讯作者: Ouyang, J (通讯作者)，Clin Res Ctr, Chongqing Publ Hlth Med Ctr, Chongqing, Peoples R China.; Yang, JD (通讯作者)，First Affiliated Hosp Chongqing Med Univ, Dept Pharm, Chongqing, Peoples R China.文献类型: Article影响因子: 2.5, JCR分区: Q2, 中信所分区: Q4学院: 附一院
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标题: Altered anterior segment biometrics in cataract patients with retinitis pigmentosa: a propensity-matched analysis suggests patterns of zonular weakness期刊: PEERJ作者: Chen, YL;Lian, ZH;Xiang, YG; et al.通讯作者: Hu, K; Zheng, SJ (通讯作者)，Chongqing Med Univ, Chongqing Eye Inst,Affiliated Hosp 1, Chongqing Branch,Municipal Div,Natl Clin Res Ctr O, Chongqing Key Lab Prevent & Treatment Major Blindi, Chongqing, Peoples R China.; Hu, K (通讯作者)，Changdu Peoples Hosp Xizang, Tibet, Qamdo, Peoples R China.文献类型: Article影响因子: 2.4, JCR分区: Q2, 中信所分区: Q4学院: 附一院; 附一院
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标题: Identifying Measurement Dimensions of Users' Benefit-Risk Perceptions of AI in Healthcare: A Scoping Review期刊: INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING作者: Shi, HN;Xiang, Y;Yang, XL; et al.通讯作者: Huang, HH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Ctr Nursing Res, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Huang, HH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Translat Med Ctr, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Review影响因子: 2.3, JCR分区: Q2, 中信所分区: Q4学院: 附一院; 附一院
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标题: Effects of epigallocatechin-3-gallate on left ventricular remodeling and functional recovery following aortic coarctation surgery期刊: BMC CARDIOVASCULAR DISORDERS作者: Yu, SY;Luo, M;Tian, J; et al.通讯作者: Liu, LF (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Anesthesiol, Chongqing, Peoples R China.; Tian, J (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Cardiol, Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China.; Tian, J; Liu, LF (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Tian, J; Liu, LF (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Tian, J; Liu, LF (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Tian, J; Liu, LF (通讯作者)，Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China.文献类型: Article影响因子: 2.3, JCR分区: Q2, 中信所分区: Q4学院: 附属儿童医院; 附属儿童医院
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标题: Paeoniflorin alleviates nephrolithiasis by targeting serpine1 and inhibiting the NF-κB signaling pathway期刊: UROLITHIASIS作者: Sun, Y;Zhang, XY;Chen, XY; et al.通讯作者: He, WY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China.; Liu, YL (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Urol, Zhengzhou 450052, Henan, Peoples R China.; Zhao, JW (通讯作者)，Guangxi Med Univ, Affiliated Hosp 1, Dept Urol, Nanning 530021, Guangxi Zhuang, Peoples R China.文献类型: Article影响因子: 2.2, JCR分区: Q2, 中信所分区: Q4学院: 附一院; 附一院
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标题: New Methods for Activated Partial Thromboplastin Time-Based Clot Waveform Analysis: Normalization and Multi-Parameter Combination期刊: INTERNATIONAL JOURNAL OF GENERAL MEDICINE作者: Dong, HM;Hu, Q;Wang, H; et al.通讯作者: Chen, H (通讯作者)，Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China.文献类型: Article影响因子: 2, JCR分区: Q2, 中信所分区: Q4学院: 附二院; 附二院
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标题: AI-augmented mixed reality for 3D visualization of perforator vessels: A feasibility study in fibular flap surgery期刊: JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY作者: Liu, YX;Wu, J;Zhao, YG; et al.通讯作者: Ji, P (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Coll Stomatol, Chongqing, Peoples R China.; Wu, SJ (通讯作者)，Southwest Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Luzhou, Peoples R China.; Wu, SJ (通讯作者)，Southwest Med Univ, Affiliated Hosp, Dept Oral & Maxillofacial Surg, Luzhou, Peoples R China.文献类型: Article影响因子: 2, JCR分区: Q2, 中信所分区: Q4学院: 附属口腔医院
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标题: Association between hemodynamic instability and noninvasive ventilation failure: A large multicenter observational study期刊: AMERICAN JOURNAL OF THE MEDICAL SCIENCES作者: Zhou, HB;Liu, XY;Wang, K; et al.通讯作者: Duan, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Youyi Rd 1, Chongqing 400016, Peoples R China.; Zhang, XF (通讯作者)，Peoples Hosp Wenjiang Dist, Dept Geriatr Resp, Kangtai Rd 86, Chengdu 611130, Sichuan, Peoples R China.文献类型: Article影响因子: 1.8, JCR分区: Q2, 中信所分区: Q4学院: 附属大足医院; 附一院
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标题: Causal association between blood immune cells and chronic hepatitis B Univariable and multivariable Mendelian randomization期刊: MEDICINE作者: Dong, JH;Peng, ZT;Qin, CF; et al.通讯作者: Shi, TD (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Affiliated Hosp 2, Dept Infect Dis,Key Lab Mol Biol Infect Dis Minis, 288 Tianwen Ave, Chongqing 400072, Peoples R China.文献类型: Article影响因子: 1.4, JCR分区: Q2, 中信所分区: Q4学院: 附二院; 附二院
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标题: Clinical significance of YAP and androgen receptor expression in osteosarcoma Evidence from a retrospective cohort study期刊: MEDICINE作者: Wang, J;Xiang, P;Zou, CQ; et al.通讯作者: Zou, CQ (通讯作者)，Chongqing Med Univ, Dept Orthopaed, Banan Hosp, Chongqing 400000, Peoples R China.文献类型: Article影响因子: 1.4, JCR分区: Q2, 中信所分区: Q4学院: 附属巴南医院
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标题: Characteristics and etiological profile of bilateral adrenal nodules: A Post-hoc analysis期刊: ENDOCRINE作者: Li, JY;Xiong, Y;Li, JL; et al.通讯作者: Li, QF; Jing, Y (通讯作者)，Chongqing Med Univ, Sichuan Chongqing Joint Key Lab Metab Vasc Dis, Chongqing Key Lab Translat Med Major Metab Dis, Affiliated Hosp 1,Dept Endocrinol, Chongqing, Peoples R China.文献类型: Article影响因子: 2.9, JCR分区: Q3, 中信所分区: Q4学院: 附一院; 附一院
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标题: Apelin-36 attenuates diabetic glomerular endothelial hyperpermeability via the KLF2/Occludin pathway期刊: PEPTIDES作者: Jiang, JX;Yang, L;Cheng, YH; et al.通讯作者: Zhou, XQ (通讯作者)，Chongqing Med Univ, Bishan Hosp, Bishan Hosp Chongqing, 382 Wenxing Rd, Chongqing 402760, Peoples R China.; Xiong, MQ (通讯作者)，Qianjiang Cent Hosp Hubei Prov, Dept Nephrol, 22 Zhanghua Middle Rd, Qianjiang 433100, Hubei, Peoples R China.文献类型: Article影响因子: 2.9, JCR分区: Q3, 中信所分区: Q4学院: 附属璧山医院
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标题: Burden of tracheal, bronchus, and lung cancer based on GBD 2021期刊: DISCOVER ONCOLOGY作者: Hu, C;Nong, SX;Meng, YX; et al.通讯作者: Hu, C; Luo, BS (通讯作者)，Dianjiang Peoples Hosp Chongqing, Dept Cardiothorac Surg, Chongqing 408300, Peoples R China.; Cheng, Y (通讯作者)，Tradit Chinese Med Hosp Dianjiang Cty Chongqing, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China.; Wang, J (通讯作者)，Chongqing Med Univ, Clin Hosp 2, Dept Resp Med, Chongqing 400010, Peoples R China.; Hu, C (通讯作者)，Wuhan Univ, Sch Med, Wuhan 430062, Peoples R China.文献类型: Article影响因子: 2.9, JCR分区: Q3, 中信所分区: Q4学院: 附二院
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标题: Transcriptome analysis of patients with loss-of-function POGZ variants in four unrelated Chinese families期刊: GENE作者: Wu, Y;Liang, N;He, FY; et al.通讯作者: Tan, B (通讯作者)，Chongqing Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 2.4, JCR分区: Q3, 中信所分区: Q4学院: 附二院
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标题: Dynapenic Abdominal Obesity and Cognitive Impairment in Type 2 Diabetic Patients: A Single-Center Cross-Sectional Study期刊: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY作者: Li, YH;Pi, Y;Ye, X; et al.通讯作者: Zhou, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 2.3, JCR分区: Q3, 中信所分区: Q4学院: 附一院; 附一院
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标题: Study on the construction of a predictive model for delayed encephalopathy after acute carbon monoxide poisoning期刊: BMC NEUROLOGY作者: Gong, HK;You, CJ;Chen, X; et al.通讯作者: Wang, YC (通讯作者)，Chongqing Med Univ, Affiliated Banan Hosp, Dept Emergency Med, Chongqing 401320, Peoples R China.文献类型: Article影响因子: 2.2, JCR分区: Q3, 中信所分区: Q4学院: 附属巴南医院; 附属巴南医院
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标题: PDK4 and RGMA as Biomarkers for Gastric Cancer Diagnosis and Prognostication: Transcriptomic and Mendelian Randomization Analyses期刊: DISCOVERY MEDICINE作者: Tu, MW;Wang, MX;Zhen, Z; et al.通讯作者: Zhang, JB (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing 400010, Peoples R China.文献类型: Article影响因子: 2.1, JCR分区: Q3, 中信所分区: Q4学院: 附二院; 附二院
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标题: Value of blended teaching in graduate tobacco medicine training: A prospective intervention study期刊: TOBACCO INDUCED DISEASES作者: Wang, HJ;Zhang, JY;Xu, XP; et al.通讯作者: Zhou, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 1.9, JCR分区: Q3, 中信所分区: Q4学院: 附一院; 附一院
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标题: HORMAD1 inhibits senescence and promotes proliferation of triple negative breast cancer by facilitating ubiquitination-mediated degradation of p27期刊: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH作者: Zong, BG;Lei, JW;Lou, M; et al.通讯作者: Li, ZF (通讯作者)，Chongqing Univ, Peoples Hosp Chongqing 4,Cent Hosp, Chongqing Emergency Med Ctr, Dept Gen Surg, Chongqing 400000, Peoples R China.; Liu, SC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing 40000, Peoples R China.文献类型: Article影响因子: 1.6, JCR分区: Q3, 中信所分区: Q4学院: 附一院
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标题: Development and validation of the parental inhaled medication literacy scale for school-age children with asthma (PIMLS-SA)期刊: JOURNAL OF ASTHMA作者: Zhang, SJ;Cui, C;Wang, ZJ; et al.通讯作者: Liu, YL (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 1.3, JCR分区: Q3, 中信所分区: Q4学院: 附属儿童医院; 附属儿童医院
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标题: Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS作者: Zhou, Y;Wu, XL;Xu, XS; et al.通讯作者: Li, JZ; Liu, YM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 40010, Peoples R China.文献类型: Article影响因子: 2.2, JCR分区: Q4, 中信所分区: Q4学院: 附二院; 附二院
第118条，共124条
标题: Suramin directly targets PI3K to alleviate experimental colitis by restoring intestinal barrier and activating autophagy期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS作者: Yan, B;Mao, XJ;Wang, SM; et al.通讯作者: Liao, ST; Mei, ZC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, 76 Linjiang Rd, Chongqing 400010, Peoples R China.; Liao, ST; Mei, ZC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Municipal Hlth Commiss Key Lab Precis Di, Chongqing 400010, Peoples R China.; Sun, J (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai, Peoples R China.文献类型: Article影响因子: 2.2, JCR分区: Q4, 中信所分区: Q4学院: 附二院; 附二院
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标题: S100A9 Integrates Autophagic Deficiency With Immunopathology and Latanoprost Responsiveness in Primary Open-Angle Glaucoma期刊: INTERNATIONAL JOURNAL OF GENOMICS作者: Hu, LL;Pan, SX;Chen, G; et al.通讯作者: Chang, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1,Ophthalmol Med Ctr, Chongqing Branch,Municipal Div,Natl Clin Res Ctr O, Chongqing Key Lab Prevent & Treatment Major Blindi, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 1.9, JCR分区: Q4, 中信所分区: Q4学院: 附一院; 附一院
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标题: Absence of lumbosacral plexus abnormalities in preschool children with tethered cord syndrome: A multiparametric MRI study期刊: CHILDS NERVOUS SYSTEM作者: Xu, SW;Tang, SL;Chen, WS; et al.通讯作者: Li, FQ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.文献类型: Article影响因子: 1.2, JCR分区: Q4, 中信所分区: Q4学院: 生物医学工程学院; 生物医学工程学院
第121条，共124条
标题: Right Axillary Thoracotomy for Anomalous Aortic Origin of a Coronary Artery in Children期刊: CONGENITAL HEART DISEASE作者: Li, K;Tang, Y;Li, YG; et al.通讯作者: Li, YG; Wu, YH (通讯作者)，Chongqing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Chongqing 400014, Peoples R China.; Li, YG; Wu, YH (通讯作者)，Minist Educ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Struct Birth Defect & Reconstruc, Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China.文献类型: Article影响因子: 1.2, JCR分区: Q4, 中信所分区: Q4学院: 附属儿童医院; 附属儿童医院
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标题: Serological Markers and EBV DNA of Epstein-Barr Virus Infection in a Health Examination Cohort from Chongqing, China期刊: VIRAL IMMUNOLOGY作者: Ou, ZJ;Wang, C;Zhao, P; et al.通讯作者: Xiang, Y (通讯作者)，Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.文献类型: Article; Early Access影响因子: 1.2, JCR分区: Q4, 中信所分区: Q4学院: 附一院; 附一院
第123条，共124条
标题: Osteoclasts may play key roles in initiating vascular calcification during atherosclerosis期刊: MEDICAL HYPOTHESES作者: Liu, YX;Wu, JQ;Chen, JR; et al.通讯作者: Zhang, HM; Li, MZ (通讯作者)，Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing, Peoples R China.; Zhang, HM; Li, MZ (通讯作者)，Chongqing Key Lab Oral Dis, Chongqing, Peoples R China.; Zhang, HM; Li, MZ (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China.; Zhang, HM; Li, MZ (通讯作者)，Chongqing Municipal Hlth Commiss, Key Lab Oral Biomed Engn, Chongqing, Peoples R China.文献类型: Article影响因子: 0.8, JCR分区: Q4, 中信所分区: Q4学院: 附属口腔医院
第124条，共124条
标题: Repair of a coronary artery fistula via right axillary thoracotomy in an infant期刊: CARDIOLOGY IN THE YOUNG作者: Dai, JT; Li, YG; Wu, YH通讯作者: Wu, YH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, Chongqing, Peoples R China.; Wu, YH (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Struct Birth Defect & Reconstruc, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China.文献类型: Article; Early Access影响因子: 0.7, JCR分区: Q4, 中信所分区: Q4学院: 附属儿童医院; 附属儿童医院
*蓝色字体部分为中信所分区Q1期刊论文，文献类型为Article和Review。
文中中文摘要由 AI 辅助翻译，准确含义以英文原文为准。
文稿：罗丽
排版|编辑|初审：李铭
复审：欧荣
终审：陈朝琴
END
临床研究
100 项与 舒洛地特 相关的药物交易
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研发状态
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10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 动脉粥样硬化 | 中国 | 2003-08-15 | |
| 糖尿病并发症 | 中国 | 2003-08-15 | |
| 血栓形成 | 中国 | 2003-08-15 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 内皮功能障碍 | 临床3期 | 墨西哥 | 2023-06-01 | |
| 新冠肺炎后遗症 | 临床3期 | 墨西哥 | 2023-06-01 | |
| 慢性静脉功能不全 | 临床3期 | 捷克 | 2021-06-08 | |
| 静脉血管疾病 | 临床3期 | 捷克 | 2021-06-08 | |
| 冠心病 | 临床3期 | 突尼斯 | 2019-01-31 | |
| 间歇性跛行 | 临床3期 | 突尼斯 | 2019-01-31 | |
| 外周动脉闭塞性疾病 | 临床3期 | 突尼斯 | 2019-01-31 | |
| 静脉功能不全 | 临床3期 | 波兰 | 2016-09-03 | |
| 复发性深静脉血栓形成 | 临床3期 | 捷克 | 2010-08-20 | |
| 静脉血栓栓塞 | 临床3期 | 捷克 | 2010-08-20 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 1,056 | (Sulodexide) | 襯觸膚構膚觸觸顧糧醖 = 鏇襯鏇窪廠窪選醖廠餘 廠簾顧夢衊遞窪襯願壓 (餘選廠網襯憲蓋鹽鏇醖, 夢鬱獵積襯衊簾廠淵鹽 ~ 鹽餘構繭築構簾齋鑰鹹) 更多 | - | 2018-03-23 | ||
Placebo (Placebo) | 襯觸膚構膚觸觸顧糧醖 = 構觸鏇夢範鏇衊壓艱獵 廠簾顧夢衊遞窪襯願壓 (餘選廠網襯憲蓋鹽鏇醖, 鹹積窪顧憲製廠築選艱 ~ 願壓構窪網範繭夢鹹窪) 更多 | ||||||
N/A | 94 | Sulodexidum 2 tb/day | 鑰醖繭壓獵製鏇憲鹹選(蓋範壓繭廠範鏇獵壓鹽) = 鏇壓淵糧構醖淵繭選壓 構鬱鏇鏇鏇鏇齋淵窪鑰 (構鏇鹽蓋願積窪衊構獵 ) | 积极 | 2016-10-01 | ||
临床2期 | 130 | 艱積窪夢夢鹽艱鹹鏇築(獵網觸網糧繭範廠壓鬱) = 遞簾繭觸蓋艱夢餘襯簾 餘餘獵選鹹獵鏇窪鏇觸 (鏇顧鏇壓衊網糧網衊繭 ) | 积极 | 2015-06-01 | |||
Placebo | 艱積窪夢夢鹽艱鹹鏇築(獵網觸網糧繭範廠壓鬱) = 選構襯壓繭簾製願鏇構 餘餘獵選鹹獵鏇窪鏇觸 (鏇顧鏇壓衊網糧網衊繭 ) | ||||||
临床3期 | 1,056 | 壓範遞鏇鑰鏇製壓廠夢(鹽艱鏇願壓夢壓齋顧鬱) = 壓築網願範蓋壓顧膚簾 範蓋構選築築構鏇壓獵 (顧淵襯夢遞膚選網壓願 ) 更多 | 不佳 | 2011-11-01 | |||
Placebo | 壓範遞鏇鑰鏇製壓廠夢(鹽艱鏇願壓夢壓齋顧鬱) = 鏇艱淵窪夢淵壓鹹餘憲 範蓋構選築築構鏇壓獵 (顧淵襯夢遞膚選網壓願 ) 更多 | ||||||
N/A | 20 | (Participants with type 2 diabetes) | 構觸顧齋壓襯繭鹽鏇糧(醖積餘觸築衊選製觸襯) = 餘蓋遞網選觸獵艱製觸 鏇獵壓鹽壓簾願衊醖糧 (網淵鏇淵艱壓網獵膚壓 ) 更多 | - | 2010-12-01 | ||
(Controls) | 構觸顧齋壓襯繭鹽鏇糧(醖積餘觸築衊選製觸襯) = 顧糧鑰遞鬱膚積積遞繭 鏇獵壓鹽壓簾願衊醖糧 (網淵鏇淵艱壓網獵膚壓 ) 更多 |
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