This study is designed to obtain preliminary data on the safety, acceptability, and feasibility of direct-to-consumer telemedicine abortion in Mexico.

开始日期2019-04-01

申办/合作机构

Gynuity Health Projects, Inc.

NCT01758536 / Unknown status临床4期IIT

A Phase IV, Double Blind, Placebo-controlled, Randomized, Multi-Center Study to Evaluate the Efficacy of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke

The purpose of this study is to determine the efficacy of Huatuo Zaizao Pills in improving neural function and life quality in patients with acute ischemic stroke in China.

开始日期2012-12-01

申办/合作机构

复旦大学附属华山医院

[+1]

NCT01416818 / Unknown status临床2期IIT

A Randomized, Double-Blind, Placebo-Controlled Study of "Xiaoyao Pill" Treatment of Depression in Patients With Parkinson's Disease

The goal of this study is to evaluate the efficacy of Traditional Chinese Medicine-"Xiaoyao Pill" (Herb extracts)on depression, compared to placebo and "Bupleurum+Ginkgo" in patients with Parkinson's disease.

开始日期2008-05-01

申办/合作机构

首都医科大学宣武医院

100 项与逍遥丸相关的临床结果

登录后查看更多信息

100 项与逍遥丸相关的转化医学

登录后查看更多信息

100 项与逍遥丸相关的专利（医药）

登录后查看更多信息

1,258

项与逍遥丸相关的文献（医药）

2024-12-01·European Journal of Medicinal Chemistry

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

Review

作者: Negi, Arvind S. ; Negi, Arvind S ; Pathak, Nandini

Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin obtained from various steroidal saponins and specially from dioscin. It possesses diverse pharmacological activities as it is capable of modulating various endogenous pathways. Diosgenin is the molecule of choice for the industrial synthesis of the steroid based clinical drugs namely progesterone, testosterone, dexamethasone, dehydroepiandrosterone, vitamin D₃, steroidal contraceptive pills, norethindrone, norgestrel etc. Diosgenin has been a molecule of discussion due to its high demand in industry as well as for future research applications. Present review describes its chemistry and detailed pharmacological profile.

2024-12-01·Journal of Ethnopharmacology

A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling

Article

作者: Liu, Yan ; Li, Xianhui ; Zhang, Hailou ; Yin, Ying ; Adzic, Miroslav ; Sun, Yan ; Liu, Ruiyi ; Yau, Suk-Yu ; Wu, Zhangjie ; Chen, Gang ; Wu, Lei

ETHNOPHARMACOLOGICAL RELEVANCEJiawei-Xiaoyao Pill (JWX), a classic formula in traditional Chinese medicine, is derived from Xiaoyao Pill by adding significant amounts of Gardeniae Fructus (GF) and Moutan Cortex (MC). It is frequently used for the treatment of depression. JWX has been demonstrated to uniquely elicit rapid antidepressant-like effects within the prescribed dosage range. To date, GF has been shown to have rapid antidepressant-like effects, but a much higher dose is required than its proportion in JWX. It is assumed that the synergism of GF with a minimum number of other herbs in JWX serves as a refined formula that exerts these rapid antidepressant-like effects. Identification of a refined formula is important for prioritizing the herbs and ingredients to optimize the quality control of JWX. However, such a refined formula for JWX has not been identified yet.AIM OF THE STUDYHere we aimed to identify a refined formula derived from JWX for optimized rapid antidepressant-like effects. Since the neuroinflammation mechanism involving in depression treatment has not been previously investigated for JWX, we tested the mechanism for both JWX and the refined formula.MATERIALS AND METHODSIndividual herbs (MC; ASR, Angelica Sinensis Radix; Bupleuri Radix; Paeonia Radix Alba) that show antidepressant-like responses were mixed with GF at the proportional dosage in JWX to identify the refined formula. Rapid antidepressant-like effects were assessed by using NSF (Novelty Suppressed Feeding Test) and other behavioral tests following a single administration. The identified formula was further tested in a lipopolysaccharide (LPS)-induced depressive model, and the molecular signaling mechanisms were investigated using Western blot analysis, immunofluorescence, and pharmacological inhibition of mTOR signaling. Scopolamine (Scop) was used as a positive control for induction of rapid antidepressant effects.RESULTSA combination of GF, MC and ASR (GMA) at their dosages proportional to JWX induced behavioral signs of rapid antidepressant-like responses in both normal and LPS-treated mice, with the antidepressant-like effects sustained for 5 d. Similar to JWX or Scop, GMA rapidly reduced the neuroinflammation signaling of Iba-1-NF-кB, enhanced neuroplasticity signaling of CaMKII-mTOR-BDNF, and attenuated the upregulated expressions of the NMDAR sub-units GluN1 and GluN2B in the hippocampus of LPS-treated mice. GMA, JWX and Scop rapidly restored the number of BDNF-positive cells reduced by LPS treatment in the CA3 region of the hippocampus. Furthermore, rapamycin, a selective inhibitor of mTOR, blunted the rapid antidepressant-like effects and hippocampal BDNF signaling upregulation by GMA.CONCLUSIONGMA may serve as a refined formula from JWX, capable of inducing rapid antidepressant-like effects. In the LPS-induced depression model, the effects of GMA were mediated via rapidly alleviating neuroinflammation and enhancing neuroplasticity.

2024-10-17·BMC public health

Assessing well-being of university students and evaluation of its determinants.

Article

作者: Szepe, Orsolya ; Meszaros, Agnes

BACKGROUNDOur study aimed to examine the well-being of students studying at the three (non-medical) faculties of Semmelweis University Budapest, to analyse the relationships between well-being, stress, emotional support, sleep patterns, sport, and further variables like smoking, consumption of sleeping pills, sedatives, psychoactive agents, energy drinks, and exam anxiety.METHODSIn our cross-sectional study, we asked 561 students of the Semmelweis University of Budapest; two internationally recognised instruments were used: the WHO-5 well-being index and the Perceived Stress Scale.RESULTSThe mean WHO-5 well-being index was 42.62 ± 20.51 on a scale ranging from 0 to 100. We saw an inverse correlation between student well-being and years of study. The average anxiety level regarding oral exams and assessments was 7.63 ± SD = 2.04, while the mean level was lower concerning written exams and assessments 5.74 ± SD = 2.09. The result of a linear regression model indicates that the best level of explaining power by the regression model was with following variables combination: grade average + anxiety before written exam + academic year + stress.CONCLUSIONOur data indicate that some students have poor or very poor well-being, which fluctuates over the study period. The worst state was found in the first and final academic year. The students' well-being level is positively correlated with emotional support, physical activity, and quality of sleep and correlates negatively with anxiety before exams. Our results suggest that well-being could be improved when universities play an active role, supporting influential activities and offering help regarding coping with stress, like stress management, as well as by providing information on learning methods and techniques.

项与逍遥丸相关的新闻（医药）

2024-10-31

·蒲公英Ouryao

国抽、省抽发新→

转自：国家药监局内蒙古药监局广西药监局编辑：水晶 10月31日，国家药监局发布19批次药品不符合规定的通告。其中，注射剂3批次，固体制剂7批次，中药饮片9批次。 10月30日，内蒙古药监局发布药品质量抽查检验不符合规定药品的通告，其中，中药饮片6批次，固体制剂1批次。 10月31日，广西药监局也发布药品质量抽查结果通告，其中中药材、中药饮片10批次，固体制剂2批次。 1、国抽品种和检测项目19批次注射剂3批次：奥硝唑注射液（2批次），丙二醇和乙醇；注射用头孢地嗪钠，水分。固体制剂7批次：甘露聚糖肽口服溶液，pH值；咪喹莫特乳膏，装量；逍遥丸（浓缩丸），微生物限度；银翘解毒丸（2批次），重量差异；一清颗粒，粒度；枣仁安神颗粒，性状。中药饮片9批次：红花（2批次），性状；红花（2批次），含量测定；合欢花（4批次），杂质、含量测定；合欢花，含量测定；山豆根，含量测定。 2、内蒙古，省抽品种和检测项目，7批次中药饮片6批次：补骨脂，含量测定；红花，水分、总灰分、含量测定；炒酸枣仁（3批次），水分；牡丹皮，性状。固体制剂1批次：香砂养胃丸（水丸），装量差异。 3、广西，省抽品种和检测项目，12批次中药材、中药饮片10批次：卷柏，含量测定；紫菀，水分；玫瑰花，性状牡丹皮，性状；淫羊藿，杂质；艾叶，杂质；五加皮，性状、【鉴别】(1)显微鉴别、【鉴别】(2)薄层色谱；延胡索(醋延胡索)，【检查】黄曲霉毒素黄芪，【含量测定】毛蕊异黄酮葡萄糖苷；桑叶，杂质。固体制剂2批次：藿香正气水（2批次），装量

上市批准

2024-10-31

·国家药品监督管理局

国家药监局关于19批次药品不符合规定的通告（2024年第47号）

经江苏省食品药品监督检验研究院等11家药品检验机构检验，共17家企业生产的19批次药品不符合规定。现将相关情况通告如下：一、经江苏省食品药品监督检验研究院检验，标示为山西国润制药有限公司生产的2批次奥硝唑注射液不符合规定，不符合规定项目为丙二醇和乙醇。经四川省药品检验研究院（四川省医疗器械检测中心）检验，标示为河南全宇制药股份有限公司生产的1批次甘露聚糖肽口服溶液不符合规定，不符合规定项目为pH值。经山东省食品药品检验研究院检验，标示为天方药业有限公司生产的1批次咪喹莫特乳膏不符合规定，不符合规定项目为装量。经天津市药品检验研究院检验，标示为汕头金石粉针剂有限公司生产的1批次注射用头孢地嗪钠不符合规定，不符合规定项目为水分。经湖南省药品检验检测研究院检验，标示为上海华源制药安徽广生药业有限公司生产的1批次逍遥丸（浓缩丸）不符合规定，不符合规定项目为微生物限度。经黑龙江省药品检验研究院检验，标示为陕西汉王药业股份有限公司生产的2批次银翘解毒丸不符合规定，不符合规定项目为重量差异。经宁波市药品检验所检验，标示为天地恒一制药股份有限公司生产的1批次一清颗粒不符合规定，不符合规定项目为粒度。经吉林省药品检验研究院检验，标示为西安万隆制药股份有限公司生产的1批次枣仁安神颗粒不符合规定，不符合规定项目为性状。经河南省药品医疗器械检验院（河南省疫苗批签中心）检验，标示为安徽亳泰中药科技有限公司、上海汇济药业芜湖有限公司生产的2批次红花不符合规定，不符合规定项目为性状；标示为安徽德昌药业股份有限公司、江西彭氏国药堂饮片有限公司、湖北大顶山制药有限公司、四川新荷花中药饮片股份有限公司生产的4批次红花不符合规定，不符合规定项目为含量测定。经浙江省食品药品检验研究院检验，标示为洛阳祯杨家药业有限公司生产的1批次合欢花不符合规定，不符合规定项目为杂质、含量测定；标示为永州市永靛中药饮片股份有限公司生产的1批次合欢花不符合规定，不符合规定项目为含量测定。经广东省药品检验所检验，标示为天马（安徽）国药科技股份有限公司生产的1批次山豆根不符合规定，不符合规定项目为含量测定。二、对上述不符合规定药品，药品监督管理部门已要求相关企业和单位采取暂停销售使用、召回等风险控制措施，对不符合规定原因开展调查并切实进行整改。三、国家药品监督管理局要求相关省级药品监督管理部门依据《中华人民共和国药品管理法》，组织对上述企业和单位存在的涉嫌违法行为立案调查，并按规定公开查处结果。特此通告。附件：1.19批次不符合规定药品名单 2.不符合规定项目的小知识国家药监局2024年10月29日国家药品监督管理局2024年第47号通告附件1.doc国家药品监督管理局2024年第47号通告附件2.doc

疫苗核酸药物

2024-08-26

·蒲公英Ouryao

微生物不合格→药企被罚没近30万！

来源：安徽药监局编辑：wangxinglai2004 2024年08月26日，安徽药监局发布了行政处罚书，上海华源制药安徽广生药业有限公司因生产的逍遥丸（浓缩丸)因微生物限度不符合规定，被罚没近30万。行政处罚决定书文号：皖药监药处罚〔2024〕3-7号违法行为类型：《中华人民共和国药品管理法》第九十八条第一款、第三款第（七）项违法事实：湖南省药品检验检测研究院检验报告（报告编号：YP202410228）称：标示上海华源制药安徽广生药业有限公司生产的“逍遥丸（浓缩丸)”（规格：每8丸相当于原药材3克，批号231213），【检查】项下“微生物限度”，需氧菌总数不符合规定。处罚依据;《中华人民共和国药品管理法》第一百一十七条第一款和《中华人民共和国行政处罚法》第三十二条第（一）项处罚类别:罚款;没收违法所得处罚名称:《国家药品抽检不符合规定产品核查函》处罚内容没收违法生产的逍遥丸（浓缩丸)（批号231213）2324瓶；没收违法所得34269.42元；并处货值金额47718元（货值金额不足十万元按十万元计算）2.6倍罚款260000元；罚没款合计294269.42元。罚款金额(万元) :26 没收违法所得、没收非法财物的金额(万元) :3.426942

财报

100 项与逍遥丸相关的药物交易

登录后查看更多信息

研发状态

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
胁腹痛	中国	湖北瑞华制药有限责任公司	2020-09-27

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WPC	N/A	-	58	Xiaoyao Pill	(壓膚構選廠餘獵襯艱齋) = 鑰鹹齋網範廠觸壓網鹹築廠窪壓夢獵夢繭構選 (願醖齋夢憲鑰獵壓窪膚 ) 更多	积极	2013-10-01
				Bupleurum+Ginkgo	(壓膚構選廠餘獵襯艱齋) = 窪積壓觸鬱鹽壓淵繭顧築廠窪壓夢獵夢繭構選 (願醖齋夢憲鑰獵壓窪膚 ) 更多