The aim of this study is to determine how two different types of iodinated contrast media (CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect specific markers of thrombogenesis and platelet function in patients undergoing coronary angiography, and if the use of bivalirudin, a direct thrombin inhibitor used during percutaneous coronary intervention (PCI), affects any contrast-related changes in thrombogenesis and platelet function.

开始日期2013-02-01

申办/合作机构

NYU Langone Health

[+1]

100 项与碘克酸钠相关的临床结果

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100 项与碘克酸钠相关的转化医学

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100 项与碘克酸钠相关的专利（医药）

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632

项与碘克酸钠相关的文献（医药）

2023-05-01·Urology practice

International Iohexol Shortage: Alternative Contrast Agents and Imaging Procedures for the Urologist.

Review

作者: Yeaman, Clinton ; Kennady, Emmett H ; Lardieri, Grant ; Schenkman, Noah

INTRODUCTIONIn April 2022, GE Healthcare announced a COVID-19-related interruption in iohexol manufacturing, leading to an international iodinated contrast shortage. The shortage greatly impacted urological practice, highlighting the value of alternative contrast agents and imaging/procedure alternatives. These alternatives are reviewed in this work.METHODSA review of existing literature describing the use of alternative contrast agents, alternative imaging procedures, and contrast conservation strategies in urological care was performed using the PubMed database. The review was not performed systematically.RESULTSOlder iodinated contrast agents such as ioxaglate and diatrizoate can replace iohexol for intravascular imaging in patients without renal impairment. These agents, along with gadolinium-based agents such as Gadavist, have been used intraluminally for urological procedures and diagnostic imaging. Several lesser-known imaging and procedure alternatives are described and include air contrast pyelography, contrast-enhanced ultrasound, voiding urosonography, and low tube voltage CT urography. Conservation strategies include contrast dose reductions and use of contrast management devices for contrast vial splitting.CONCLUSIONSThe COVID-19-related iohexol shortage caused significant hardship for urological care internationally, leading to delayed contrasted imaging studies and urological procedures. Alternative contrast agents, imaging/procedure alternatives, and conservation strategies are reviewed in this work with the goal of equipping the urologist to mitigate the current iodinated contrast shortage and to prepare in the event of a future shortage.

2023-04-11·ACS Nano

Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis

Article

作者: Bajpayee, Ambika G. ; Charles, Julia F. ; Vedadghavami, Armin ; He, Tengfei ; Zhang, Chenzhen

Cartilage tissue exhibits early degenerative changes with onset of osteoarthritis (OA). Early diagnosis is critical as there is only a narrow time window during which therapeutic intervention can reverse disease progression. Computed tomography (CT) has been considered for cartilage imaging as a tool for early OA diagnosis by introducing radio-opaque contrast agents like ioxaglate (IOX) into the joint. IOX, however, is anionic and thus repelled by negatively charged cartilage glycosaminoglycans (GAGs) that hinders its intra-tissue penetration and partitioning, resulting in poor CT attenuation. This is further complicated by its short intra-tissue residence time owing to rapid clearance from joints, which necessitates high doses causing toxicity concerns. Here we engineer optimally charged cationic contrast agents based on cartilage negative fixed charge density by conjugating cartilage targeting a cationic peptide carrier (CPC) and multi-arm avidin nanoconstruct (mAv) to IOX, such that they can penetrate through the full thickness of cartilage within 6 h using electrostatic interactions and elicit similar CT signal with about 40× lower dose compared to anionic IOX. Their partitioning and distribution correlate strongly with spatial GAG distribution within healthy and early- to late-stage arthritic bovine cartilage tissues at 50-100× lower doses than other cationic contrast agents used in the current literature. The use of contrast agents at low concentrations also allowed for delineation of cartilage from subchondral bone as well as other soft tissues in rat tibial joints. These contrast agents are safe to use at current doses, making CT a viable imaging modality for early detection of OA and staging of its severity.

2023-03-04·Connective Tissue Research

Early patellofemoral cartilage and bone pathology in a rat model of noninvasive anterior cruciate ligament rupture

Article

作者: Hartner, Samantha E. ; Fleischer, Mackenzie M. ; Maerz, Tristan ; Baker, Kevin C. ; Newton, Michael D.

OBJECTIVEAnterior cruciate ligament rupture (ACLR) is a risk factor for the development of post-traumatic osteoarthritis (PTOA). While PTOA in the tibiofemoral joint compartment is well-characterized, very little is known about pathology in the patellofemoral compartment after ACL injury. Here, we evaluated the extent to which ACLR induces early patellofemoral joint damage in a rat model.METHODSAdult female Lewis rats were randomized to noninvasive ACLR or Sham. Two weeks post-injury, contrast-enhanced micro-computed tomography (µCT) of femoral and patellar cartilage was performed using 20% v/v ioxaglate. Morphometric parameters of femoral trochlear and patellar cartilage, subchondral bone, and trabecular bone were derived from µCT. Sagittal Safranin-O/Fast-Green-stained histologic sections were graded using the OARSI score in a blinded fashion.RESULTSCartilage and bone remodelling consistent with an early PTOA phenotype were observed in both femoral trochleas and patellae. ACLR caused osteophyte formation of the patella and pathology in the superficial zone of articular cartilage, including surface fibrillation, fissures, increased cellularity, and abnormal chondrocyte clustering. There were significant increases in thickness of patellar and trochlear cartilage. Loss of subchondral bone thickness, bone volume fraction, and tissue mineral density, as well as changes to patellar and trochlear trabecular microarchitecture, were indicative of catabolic bone remodelling. Several injury-induced changes, including increased cartilage thickness and trabecular spacing and decreased trabecular number were more severe in the patella compared to the trochlea.CONCLUSIONThe patellofemoral joint develops mild but evident pathology in the early period following ACL rupture, extending the utility of this model to the study of patellofemoral PTOA.

100 项与碘克酸钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04599	碘克酸钠	V08AB03	DB09313

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01848899 (CTgov)	临床4期	血栓形成 \| 冠心病	100	Bivalirudin+Ioxaglate (Ioxaglate Arm)	鹽網簾糧廠夢蓋膚糧餘(憲構遞網窪範顧鬱製廠) = 願觸鹽範觸壓鏇網鹽醖鬱製鏇憲夢襯鏇廠願齋 (齋壓積鏇壓憲鏇鬱願餘, 艱糧夢積廠糧蓋願餘鏇 ~ 廠積網積顧夢淵膚廠壓) 更多	-	2016-04-06
				Bivalirudin+Iodixanol (Iodixanol Arm)	鹽網簾糧廠夢蓋膚糧餘(憲構遞網窪範顧鬱製廠) = 襯艱網淵糧壓醖窪膚網鬱製鏇憲夢襯鏇廠願齋 (齋壓積鏇壓憲鏇鬱願餘, 衊獵範積選鬱鬱願憲廠 ~ 醖鬱獵鬱艱醖鏇簾顧鑰) 更多