Sibutramine Hydrochloride

摘要：癌症仍是全球最严峻的健康挑战之一，其疾病负担持续攀升。由于传统抗癌疗法缺乏组织选择性导致的局限性，亟需开发更安全、更具选择性的靶向肿瘤治疗方案。对癌症基本特征的识别为有效靶向肿瘤提供了全面的生物学认知，涵盖促瘤性炎症、代谢重编程、免疫逃逸、基因组不稳定性、表型可塑性、表观遗传重编程及多态性微生物组等机制。此外，药物再利用作为一种经济高效且省时的癌症治疗策略，通过重新利用现有药物开发新适应症，加速了药物发现进程。当前研究聚焦于将药物再利用与纳米载体相结合，通过单一纳米制剂实现增强肿瘤靶向性、降低副作用及提高药物生物利用度的目标。本文分析了封装不同类别药物（如苯乙肼、非索非那定、替米沙坦、氯沙坦、二甲双胍、坎格列净、阿托伐他汀和芬苯达唑）的各类纳米颗粒，重点探讨其抗癌效应及纳米载体对药物疗效的影响。结果表明，与游离药物溶液相比，药物封装纳米颗粒的抗肿瘤效果显著提升，这归因于纳米载体功能化、药物缓释及肿瘤内细胞摄取改善所实现的协同作用，从而靶向干预多种癌症特征。此外，本综述还指出纳米制剂临床转化面临的现存挑战，并阐释人工智能如何助力药物筛选与鉴定、治疗优化及大规模生产。最终，将这些技术与药物再利用相结合，为推进癌症治疗提供了前景广阔的发展方向。 关键词：药物重定位、癌症特征、机器学习、智能纳米颗粒 引言 癌症是二十一世纪造成重大社会、经济和公共卫生挑战的主要原因之一，全球报告显示其死亡率居高不下。根据美国癌症协会数据，2022年全球约有2000万新增癌症确诊病例，并报告了970万例癌症相关死亡病例。这些数据表明约五分之一的人可能在一生中罹患癌症。目前预测显示，到2050年新增癌症病例数将攀升至超过3500万例[1]。与此同时，新型抗癌药物的研发已变得极其昂贵且耗时。据估算，将一款新抗癌药物推向市场可能耗费约20‑30亿美元[2]。为应对这些挑战，药物重定位已成为一种前景广阔的策略，即利用现有药物治疗新适应症。该方法为加速抗癌药物开发提供了成本效益高且省时的替代方案[2]。 除了其优势外，抗癌药物重定位的成功取决于对癌症生物学的深入理解，尤其是驱动肿瘤进展的分子通路和细胞机制，以实现有效的肿瘤靶向。此外，许多被重定位的药物面临诸如水溶性差、生物利用度有限和全身毒性等挑战[3]。这些不利的理化性质是其成功临床转化的主要障碍。因此，基于纳米载体的递送系统为这些挑战提供了强有力的解决方案，因为它们提高了药物的生物利用度，增强了肿瘤靶向性，延长了药物释放时间，并降低了全身毒性。因此，纳米载体为抗癌药物重定位提供了一个多功能平台，能够通过表面功能化引入肿瘤靶向基团，并利用聚合物提供协同效应，从而进一步提升整体治疗效果[3]。 本文阐述了如何通过药物重定位技术靶向癌症特征标志物，并结合纳米技术提升药物整体疗效。文章系统回顾了癌症的发病机制、药物重定位策略及纳米医学在癌症治疗中的应用，并通过讨论部分的案例研究深入探讨载药纳米载体的理化特性、抗癌属性及靶向机制。同时，通过将纳米载体的每种抗癌机制与对应癌症特征标志相关联，本综述建立了纳米载体设计与治疗结果间的逻辑关联。最后，文章指出了当前可能限制纳米制剂临床转化的挑战。 癌症的发病机制 癌症被定义为一种复杂的多因素疾病，涉及正常细胞向恶性肿瘤的转化[4]。这种转化的原因已被研究数十年。2000年，研究者Hanahan和Weinberg开展了一项开创性研究，塑造了癌症研究的未来。他们的工作概括了癌症的主要特征标志，以及癌细胞从正常细胞恶变过程中获得的关键生物学能力。如图1所示，癌症特征包括：抵抗生长抑制信号、维持生长信号、逃避凋亡、不受控的细胞分裂、诱导血管生成，以及激活组织侵袭和转移[5]。 这些特性使得细胞能够以不受控制的方式在体内存活、增殖和扩散。这些标志性特征为理解癌症发展奠定了基础；然而，2011年Hanahan和Weinberg发表了该研究的更新版本，引入了对癌症发展的新见解。这一更新框架识别出了更多特征及新兴可能对癌症经典标志特征有所贡献的标志，包括(图1)： 能量代谢重编程 癌细胞依赖糖酵解而非线粒体氧化磷酸化来产生能量，这导致三磷酸腺苷（ATP）产量较低。尽管糖酵解每分子葡萄糖产生的ATP较少，但癌细胞通过上调葡萄糖转运蛋白（GLUT1）来补偿这种效率损失，从而增加细胞质中的葡萄糖摄取。此外，糖酵解代谢与某些癌基因的激活以及突变的肿瘤抑制基因TP53有关，这些变化促进细胞增殖并抑制细胞凋亡。此外，肿瘤内的缺氧条件进一步增强了糖酵解作用，缺氧反应系统通过激活葡萄糖转运蛋白和糖酵解酶，最终提高了葡萄糖的利用率。这些遗传变化上调了糖酵解酶和葡萄糖转运蛋白，促进了糖酵解供能。这种转变为癌细胞提供了代谢优势，为快速细胞生长和分裂提供了必要的能量和构建模块[6]。 逃避免疫摧毁 免疫系统在检测和清除癌细胞中起着至关重要的作用。免疫系统通过多种机制逃避免疫监视。一个关键因素是癌细胞会发生基因改变，导致肿瘤特异性抗原的产生。这些抗原使免疫系统能够区分恶性细胞与正常细胞[6]。在正常生理条件下，免疫系统会按以下步骤对抗原作出反应并激活：首先，T细胞受体通过主要组织相容性复合体（MHC）分子识别抗原呈递细胞（APCs）表面呈现的特定抗原。这种识别启动了T细胞激活的第一信号[7]。其次，T细胞上的共刺激受体（CD28）与APC上的配体结合，提供T细胞完全激活所需的第二信号。一旦激活，T细胞就能有效清除癌细胞。然而，为防止过度免疫激活和潜在的组织损伤，T细胞会下调其活性。诸如细胞毒性T淋巴细胞相关抗原4（CTLA‑4）和程序性细胞死亡蛋白1（PD‑1）等抑制性受体负责下调T细胞激活。因此，PD‑1与其配体（PD‑L1和PD‑L2）结合，阻断第一信号（抗原识别）并抑制T细胞激活。而CTLA‑4则以比CD28更高的亲和力与CD80和CD86结合，这些配体原本与CD28结合，从而阻断第二信号（共刺激）并阻止T细胞激活[7]。共刺激信号与抑制机制之间的平衡被称为免疫检查点。正常情况下，这些检查点对于维持自身耐受、预防自身免疫以及避免因感染反应导致过度组织损伤至关重要[8]。 在癌症背景下，PD‑1通路可被肿瘤细胞利用以逃避免疫检测。许多肿瘤表面表达PD‑L1，其能与肿瘤浸润淋巴细胞上的PD‑1结合。这种相互作用会抑制T细胞活性，使肿瘤细胞得以增殖。此外，免疫抑制的关键调节者——调节性T细胞（Treg细胞）同样表达PD‑1。由于许多肿瘤组织中存在大量Treg细胞浸润，会进一步抑制免疫应答，从而在保护肿瘤免受免疫攻击的同时促进肿瘤增殖[8]。然而，肿瘤能够逃避免疫监视。 基因组不稳定性与突变 肿瘤会随时间积累多重突变，导致其不受控地生长。正常情况下，细胞具有修复机制来应对突变造成的DNA损伤。其中TP53是重要的参与基因，它作为基因组守护者，能监测DNA损伤并触发细胞周期停滞或凋亡以应对遗传损伤。 相反，癌细胞经常表现出TP53基因的缺陷，这会导致突变率升高，而这些突变会破坏负责维持基因组完整性的监控机制，从而促进癌细胞不受控制地生长[6]。 尽管此前的标志性特征为理解癌症生物学提供了有价值的框架，但它们并未涉及使肿瘤获得此类恶性特征的潜在分子和细胞机制，并且不足以全面阐释癌症发病机制的复杂性[9]。因此，Hanahan于2022年[9] 发表了《癌症特征》理论的更新文章，阐明了促进肿瘤发展的关键过程（如图1所示），包括： 图1 癌症的特征 解锁表型可塑性 细胞改变其身份和功能（表型）转变为另一种细胞类型的能力被称为细胞可塑性。在正常生理状态下，这可能是一种有益的适应机制。例如，细胞可塑性可能因炎症或损伤而发生。这一过程被称为转分化。此类机制通过替换受损组织或形成屏障以抵御致病条件，成为对抗慢性损伤的保护性过程。然而，失调或过度的细胞可塑性，尤其是跨多个组织发生时，可能增加癌症进展的易感性[10]。最近一项研究证实，可塑性是癌症起始和进展的基础，它使癌细胞能够适应并逃避治疗，导致细胞对不同治疗策略产生耐药性[9, 11]。 非突变性表观遗传重编程 如前所述，基因突变是癌症形成的主要原因；然而，不改变 DNA 序列的基因表达变化也能成为癌症进展的重要原因。这种现象被称为表观遗传变化[9]。表观遗传修饰的诱因之一是肿瘤微环境（TME）的异常物理特性，这将在后文中详述。TME驱动的表观遗传调控典型案例是实体瘤边缘癌细胞侵袭行为的可逆激活。该过程由EMT介导，这是一种发育调控机制，通过驱动表观遗传修饰来增强细胞可塑性和转移潜能，同时提升迁移能力、生存能力和耐药性[9]。 多态微生物组 众所周知，人体内寄居着多样化的微生物组，它们与宿主之间进行着复杂的相互作用。值得注意的是，这些微生物组的个体间差异会深刻影响癌症的发生、发展及治疗反应[9]。近期一项研究表明，患者个体中独特的微生物组可通过物理粘附或释放代谢物与毒素来促进肿瘤发生，从而导致基因组不稳定、表观遗传改变以及多种信号通路的激活。此外，这一过程还会破坏免疫系统并引发炎症。微生物组与宿主细胞（包括肿瘤细胞和免疫细胞）之间的相互关联极为复杂，可能引发遗传、表观遗传、转录及代谢层面的初始性改变，这有待进一步研究[12]。 理解TME 肿瘤微环境（TME）是围绕肿瘤的一个复杂生态系统，负责癌症代谢和进展。该环境以酸性本质和缺氧条件为特征，同时伴随着内源性过氧化氢（H2O2）的产生以及细胞外基质蛋白表达的变化。值得一提的是，由膜蛋白通过无氧糖酵解排泄质子（H+）和乳酸产生的酸性pH是细胞侵袭的关键因素，因为它促进血管生成因子的表达，包括VEGF A和白细胞介素（IL）。此外，随着肿瘤的生长，中心部位的细胞由于与血管的距离增加而变得缺氧。为了克服这一限制并确保持续生长，肿瘤细胞增加了如VEGF等血管生成因子的产生，这些因子刺激新血管的形成。然而，新生血管化导致血管结构异常，因为肿瘤相关血管的内皮细胞存在多个间隙，导致血管渗漏。此外，低浓度下，ROS如H2O2, 在各种生理过程中扮演关键角色。然而，H2O2 水平升高会导致氧化应激，最终引起细胞损伤和功能障碍。有趣的是，癌细胞利用ROS的产生来获得优势，它们利用ROS来调节信号通路、增加增殖、适应缺氧并发展出化疗耐药性[7]。 这些特征共同作用，使癌细胞得以发展并绕过正常的生长控制，导致细胞分裂失控和肿瘤进展。如图所示，这些特征的发展涉及一个由多种信号通路调控的复杂机制。有趣的是，种系突变在所有癌症中只占少数原因，因为大多数肿瘤是由体细胞突变和环境因素引起的。癌症的环境诱因通常与炎症相关。其他因素如慢性感染、吸烟、吸入污染物和肥胖，也会促进癌症的发展[4]。因此，深入理解癌症的发病机制有助于通过靶向这些潜在机制来制定有效的治疗策略。目前，标准的抗癌治疗依赖于手术、放疗和化疗的组合，其中化疗和放疗主要通过诱导癌细胞DNA损伤来发挥作用。然而，这些治疗也会损伤健康组织，导致周围正常细胞的DNA损伤，从而引发全身毒性。 其他常见副作用包括癌症复发的可能性、耐药癌细胞的出现，以及与治疗相关的继发性恶性肿瘤和器官特异性损伤（如肾毒性、肝毒性、神经毒性、心脏毒性和耳毒性）等并发症[13, 14]。 除了传统疗法带来的衰弱副作用外，肿瘤的多药耐药性(MDR)导致近90%接受传统化疗或新型靶向药物治疗的癌症患者死亡。MDR通过多种分子机制产生，包括药物外排增加、药物代谢增强、DNA修复能力提升，以及基因突变和表观遗传修饰。这些反应共同降低了治疗效果，并使癌症治疗变得极为复杂[15]。 癌症中MDR的主要机制涉及4种ATP结合盒(ABC)转运蛋白的上调，例如p‑糖蛋白(MDR1)、多药耐药相关蛋白1(MRP1)、多药耐药相关蛋白2(MRP2)和乳腺癌耐药蛋白(ABCG2)。这些外排泵能主动将多种化疗药物排出肿瘤细胞[16]。此外，抗凋亡蛋白如B细胞淋巴瘤2(BCL‑2)的上调，以及促存活信号通路的激活，也是MDR形成的原因[17]。 因此，当前的研究方向集中于寻找既能最大限度减少不良反应、又能实现最佳抗癌疗效的理想治疗药物。药物重定位已成为这一领域内的创新策略，为抗癌药物研发提供了前景广阔的新途径。 药物重定位 从初始研究到监管批准，发现和开发一种新药是一个繁琐、昂贵且耗时的历程。平均而言，这一过程可能需要13年时间，耗资约20‑30亿美元才能将一种新药推向市场。因此，药物再利用方法是一种节省时间的过程，其中已获得食品药品监督管理局（FDA）等监管机构批准的药物会被重新开发并用于新的适应症[2]。随着多药耐药性（MDR）严重损害各种癌症类型的治疗效果，制药公司越来越多地采用药物再利用策略，以识别能够绕过耐药机制的新型抗癌剂。例如，维拉帕米已被证明可作为p‑糖蛋白抑制剂，有效逆转卵巢癌中的耐药性[17]。类似地，环孢素A作为一种强效的p‑糖蛋白抑制剂，能够有效克服癌细胞中对紫杉醇的耐药性p‑糖蛋白过度表达[18]。过去十年间，来自不同药理类别的数百种药物已被探索其潜在的抗癌特性。虽然其中一些药物已进入临床试验阶段，但其他药物仍处于临床前研究的调查中。表I和II列出了不同药物的示例及其癌细胞靶点和当前临床状态。 表I 临床前研究中研究的再利用药物示例及其靶向癌细胞类型 表II 目前处于临床试验阶段、用于癌症治疗的再利用药物示例 以及其作用机制 这些成功案例彰显了药物重定位在现代药物开发中的重要意义。因此，理解指导药物重定位的核心原则至关重要。通常，药物重定位主要依赖两大核心原则：或是由于疾病间存在共同的病理生理机制，使对某疾病有效的药物可能获得治疗其他病症的潜力；或是药物通过脱靶效应和多通路调节作用与多个靶点或通路产生交互。由此，新药物适应症的发现可能通过假设驱动或偶然发现两种途径实现[83]。其中，假设驱动法作为前景广阔的重定位方法已被广泛研究和应用。这类方法涉及实验与计算策略，如图2所示，该图汇总了实现成功药物重定位成果的双重策略及所用技术。 图2 基于假设的药物重定位策略 从实验策略入手，常采用结合试验和表型筛选等技术。首先，结合试验通过测量配体结合时蛋白质热稳定性或溶解度的变化，来研究配体与靶蛋白之间的相互作用。细胞热位移分析（CETSA）、热蛋白质组分析及蛋白质组整体溶解度变化（PISA）等技术被广泛用于鉴定测试化合物的蛋白质靶标[84, 85]。该方法的一个典型例子是将抗寄生虫药乙胺嘧啶用于癌症治疗。通过PISA技术可明确发现，乙胺嘧啶的作用机制源于抑制人类二氢叶酸还原酶，最终阻断促进肿瘤发生的STAT3信号通路[85]。这些结果通过人类二氢叶酸还原酶对热变性的稳定性得以揭示，证实该酶是药物的直接分子靶点[85]。乙胺嘧啶还显著降低了癌细胞中的ATP水平。值得注意的是，所发现的乙胺嘧啶抗癌机制主要针对代谢重编程和持续生长信号这两大癌症特征[85]。 另一方面，表型筛选通过测试大型化合物库对生物系统（如细胞系或动物模型）的作用来识别化合物，其鉴定依据是化合物对细胞表型改变的诱导作用。当活性化合物被识别后，将进一步研究以确定其与疾病状态的相关性并检测其潜在作用机制[84]。例如，最近一项研究对1,280种食品药品监督管理局批准的药物进行了针对人类结直肠癌模型的高通量表型筛选。结果显示，他汀类药物（尤其是匹伐他汀）表现出最强的抗癌效果。为验证这些结果，体外细胞毒性试验证实，匹伐他汀治疗可诱导肿瘤内促炎基因表达，从而增强抗肿瘤免疫[86]。 通过结合表型筛选和结合实验，研究人员可以识别出具有再利用潜力的候选药物，从而加速并优化整体药物发现流程[87]。 当前，传统药物重定位研究主要致力于识别药物作用机制（MoA）相似性与药效；通过针对新型生物靶标筛选现有药典来发现药物新适应症；分析包括分子结构和不良反应在内的常见药物特性；或阐明药物间的关联关系与疾病[83]。相比之下，许多重定位技术缺乏疾病特异性，因其依赖于从不同生物框架获取的药物机制和通路数据，而这些信息未必总能适用于相关药物[88]。这种方法的差异性常导致不同研究报告结果存在不一致性。 为应对这些局限性，计算驱动的药物再利用策略正迅速兴起，这得益于近期公开的大规模生物医学、生物学及电子健康相关数据的扩展，以及高性能计算能力的提升[83]。 因此，计算药物重定位的成功很大程度上依赖于对强大且全面数据库的访问。表III列举了该领域最广泛使用的一些数据库。例如，DrugBank、PubChem和ChEMBL等数据库提供的化学与药理学数据，可支持识别有潜力的候选药物及训练机器学习模型。此外，蛋白质相互作用数据可通过STITCH获取，STRING和BindingDB等数据库对预测药物‑靶点相互作用至关重要。与此同时，蛋白质数据库通过3D靶点‑药物复合体支持基于结构的药物发现。此外，癌细胞系百科全书提供的基因组数据对肿瘤学应用具有重要价值[21, 83, 89–91]。 表III 常见数据库及其关键特性示例 此外，计算方法的主要优势之一在于，基于化学结构来评估特定性质或活性的预测工具可能提供更高的预测准确性[88]。这些工具包括数据挖掘与语义推理、机器学习（ML）、网络生物学、全基因组关联分析、组学驱动的特征匹配以及in silico研究。它们共同克服了传统统计方法的局限性，提供了更可靠的数据洞察[83, 89]。此外，这些方法学支持诸如基于靶点、基于知识、基于特征、基于通路以及基于靶点‑机制等药物重定位策略[83, 84, 92]。例如，基于靶点的策略依赖于已知靶点（如与某种疾病相关的特定蛋白质或生物标志物）与测试化合物之间的相互作用。该策略采用配体筛选或分子对接等计算技术来预测这些相互作用[92]。相比之下，基于知识的重定位利用药物现有信息来揭示新机制，例如未识别的药物靶点或新型生物标志物。这种方法通过生物信息学、化学信息学及数据挖掘等工具支持，能够检测单一药物的多种适应症[84]。 尽管如此，基于通路的方法利用了疾病相关的组学数据，通过绘制疾病相关分子通路来发现药物再利用的新靶点。该方法利用代谢和信号通路中的信息，预测药物与疾病之间潜在的关联性或相似性[84, 92]。例如，一项研究利用生物信息学分析、分子对接、分子动力学模拟和蛋白质‑蛋白质相互作用网络，探索抗血管生成药物恩扎妥林治疗结直肠癌的治疗机制。尽管该药物此前已用于癌症治疗，但该研究发现了参与结直肠癌发病机制的关键失调基因，包括蛋白质磷酸化的正向调控、细胞凋亡的抑制、蛋白质酪氨酸激酶活性、黏着斑通路以及磷酸肌醇‑3‑激酶调节亚基1信号通路。值得注意的是，该药物对两个关键枢纽蛋白（包括caspase‑3和髓系细胞白血病1蛋白MCL1）表现出强结合亲和力，这些蛋白与癌症进展密切相关[93]。 类似地，基于特征的重定向策略依赖于从疾病相关组学数据中获取的基因表达模式，以揭示药物先前未被识别的脱靶效应或未被发现的靶向疾病机制。该方法通过分析基因和蛋白质表达的变化，能够识别新的药物作用机制[84]。最近一项研究利用膀胱癌相关蛋白质组学和转录组学数据，鉴定出能够逆转相关分子特征的药物将侵袭性高风险非肌层浸润性膀胱癌的分子特征转变为侵袭性较低的低风险亚型。通过这种组学指导的方法，哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂WYE‑354脱颖而出，成为具有潜力的重定向候选药物，展现出强大逆转侵袭性膀胱癌分子特征的能力。 最后，基于靶标机制的方法整合了来自信号通路、蛋白质‑蛋白质相互作用网络和治疗相关组学的数据，以揭示药物的新作用机制。这一策略为治疗特异性机制提供了宝贵见解，并支持精准医学的开发[84]。除了这些重新利用策略外，成功的计算药物再利用依赖于强大的工具，如机器学习（ML），以提高药物发现的效率和精确性。 机器学习利用先进算法在复杂数据集中发现隐藏模式。在药物研发领域，该技术能促进治疗靶点的识别与验证，同时提升化合物筛选和药物设计效率。此外，它还可推动生物标志物发现、优化精准医疗中的患者分层，并改进临床试验设计。基于这些能力，机器学习尤其适用于肿瘤学应用，因为它能通过文献挖掘、电子健康记录分析和药物‑靶点相互作用模型实现药物重定位[94]。值得注意的是，机器学习能够克服实验性药物重定位的缺陷。例如，传统基于细胞的表型筛选难以阐明已识别靶点化合物活性的精确分子机制。为突破这一局限，PRISM（混合样本相对抑制谱分析）技术提供了革命性方法，可精准测试候选药物对人类癌细胞系的作用，大幅提升筛选效率。Corsello等人[95] 就采用PRISM条形码混合检测法，测试了4,518种现有药物对578种癌细胞系的作用。通过机器学习算法分析化合物响应模式，成功预测了癌细胞系对多数药物的敏感性，这些预测源自癌细胞系的基因组特征，从而提示了潜在适用的患者群体[95]。模型输入数据包括DNA甲基化水平、microRNA、基因拷贝数、热点或错义突变以及信使RNA等分子特征。结果显示大量非抗癌药物表现出选择性抗癌活性，其效果可通过癌细胞系的分子特征预测。其中包括双硫仑（选择性杀伤低金属硫蛋白表达的癌细胞）和抗炎药替泊沙林（通过MDR蛋白ABC亚家族B成员发挥抗癌作用）1 [95]。本文阐明了PRISM技术结合机器学习与多组学数据，可为加速药物重定位进程和揭示药物新机制提供强大框架。另一个成功案例是Ramesh团队最近的研究[96] ，他们通过机器学习模型将孟鲁司特识别为潜在RET（转染重排）抑制剂——一种用于治疗非小细胞肺癌的受体酪氨酸激酶。该研究使用2,854种化合物评估食品药品监督管理局批准药物对RET蛋白的抑制效力。预测模型采用系统方法开发：初始阶段包括数据准备与收集，通过检索、整理和过滤数据使其适用于机器学习模型的训练与测试。 作者最初从BindingDB数据库中获取了9,914种针对RET蛋白测试的化合物。通过去除重复项并以范德他尼药物为参考标准将化合物分类为活性与非活性后，这一数量减少至2,854种具有IC50 值的化合物，同时排除了无IC50 值的候选物[96]。这一数据筛选至关重要，因为建立平衡的数据集对于开发稳健的预测模型极为关键，显著的类别不平衡会严重降低机器学习性能[97]。数据准备完成后，使用ChemSAR标准化工具对化学结构进行优化，包括净化、断开金属键、应用归一化规则、酸再离子化及重新计算化合物的立体化学[96]。随后，化学结构通过分子描述符转化为数值。这些描述符（如PaDEL描述符）编码了化合物的物理化学特性（结构、拓扑、几何及电化学性质），使化学结构可量化以用于计算分析和预测建模[97]。 随后的关键阶段涉及特征选择，通过识别最佳预测变量并排除无关变量来提升模型性能。这一过程减少了过拟合现象，并通过节省预测时间提高了计算效率[97]。作者实施的众多特征选择方法中，采用了基于交叉验证的递归特征消除法（RFECV），因其高精度特性。RFECV根据变量与目标之间计算得出的相关性水平，识别出最显著且相关的特征[96]。 在识别出关键特征后，作者们着手进行机器学习模型开发。该框架通过在活性化合物及其性质的精选数据集上训练预测性机器学习模型，从而实现对未知化合物活性的预测[97]。本研究采用多种机器学习算法进行评估，包括逻辑回归（LR）、随机森林（RF）、支持向量机（SVM）、朴素贝叶斯（NB）、梯度提升（GB）、决策树（DT）以及神经网络（NN）。这些模型因其快速处理能力和预测准确性，被广泛应用于分类建模。结果显示，SVM模型获得了最高准确率，而NB在分析中表现最差。SVM模型共识别出497种活性分子，表明该模型能以高精度将化合物分类为活性与非活性物质，有望成为筛选大型数据库的虚拟管道的理想选择。 此外，一项计算机模拟研究采用分子对接技术，通过评估所发现化合物与RET蛋白结合位点的相互作用来验证这些发现。结果表明，孟鲁司特和碘克沙酸被鉴定为最具潜力的药物。进一步通过分子动力学模拟，基于结合稳定性，孟鲁司特被确定为RET抑制剂的首选。随后，该药物在肺癌细胞系中的活性评估揭示了其细胞毒性，并通过ADMET分析证实其具备适宜的药代动力学特性[96]。图3直观展示了基于机器学习的孟鲁司特发现流程，突出了各阶段的关键步骤并总结了每个环节的主要发现。同时，该图也说明了计算方法如何指导孟鲁司特的鉴定过程。 图 3 用于发现 RET 抑制剂的机器学习药物再利用流程。ML：机器学习 此外，另一项研究也证明了利用机器学习（ML）成功重新利用抗生素Eravacycline治疗胰腺导管腺癌（PDAC）的案例，该研究采用了神经网络模型Chemprop。该模型主要通过从数据库（如DrugBank和Clinical‑Trials.gov）获取数据，对具有抗癌潜力的药物进行排序。为进一步提升模型预测能力，研究者整合了分子结构、药物‑药物相互作用及药物‑靶点相互作用数据。值得注意的是，四环素类抗生素因在加入药物‑药物相互作用数据后持续表现出高模型准确率，被确定为有前景的抗癌候选药物。其中，合成卤化四环素Eravacycline排名最高，表明其具有显著的抗癌特性[88]。尽管药物‑靶点生物活性数据有助于预测化合物对靶点的调控作用及效力，但这些信息通常缺乏细胞层面的背景。由于药物的作用机制（MoA）高度依赖特定细胞环境，利用相关细胞系统进行实验验证仍至关重要[98]。因此，为验证模型的预测准确性，研究者开展了体外实验，评估药物效力排名是否与实际生物活性相关。研究采用多种细胞系（如人乳腺癌、肺、结肠及PDAC细胞）比较Eravacycline与其他药物（如替加环素和奥马环素）对这些癌症的抑制效果。结果显示，Eravacycline对胰腺癌细胞的治疗能强力抑制肿瘤生长（抑制率约90–93%），而替加环素仅表现出中等抗增殖效果（生长抑制率为60–65%）。奥马环素的活性较弱，生长抑制率为40%。这些结果表明，Eravacycline在抑制PDAC细胞增殖方面显著优于其他四环素类药物[88]。 上一部分阐述了机器学习在药物重定向中的影响，揭示了其精准高效识别癌症治疗药物的能力，并通过实验测试或计算机模拟研究加以验证和补充。整合多重重定向策略可增强机器学习预测的可信度，提升其准确性，并强化对已识别药物治疗潜力的信心。 然而，尽管药物识别是药物重定位过程中的关键步骤，但许多候选药物仍面临溶解性差、生物利用度有限和全身毒性等挑战。例如，抗高血压药物替米沙坦的水溶性低，限制了其生物利用度和治疗效果[99],而抗抑郁药苯乙肼则因其神经副作用使用受限[100]。这些发现凸显了药物重定位过程中的一个主要缺陷——已识别药物的不良理化性质可能极大限制其临床转化。为此，基于纳米载体的系统已成为一种前景广阔的解决方案，它能提供改善的生物利用度、降低的全身毒性和增强的治疗潜力，标志着其在推进癌症治疗中的关键作用。 纳米技术在癌症领域的应用 由于癌症是一种具有遗传、分子和细胞起源的复杂多因素疾病，它需要创新的诊断和治疗方法以实现有效治疗。随着药物重定位的发展，基于纳米技术的医学作为一种有前景的解决方案应运而生，提供了新型药物递送系统、多功能诊断工具和治疗剂，以更有效地对抗癌症。纳米医学利用纳米技术预防和治疗疾病，使用纳米级材料，如生物相容性纳米颗粒（NPs），用于药物递送和诊断等不同应用[101]。NPs的尺寸范围在1至1000纳米之间，由于其微小尺寸和大表面积，具有独特的物理化学性质。 近年来，生物相容性NPs已被应用于癌症治疗研究，以缓解传统疗法的局限性，包括药物溶解度低、生物利用度差、肿瘤定位有限以及缺乏组织特异性。这些NPs为抗癌药物递送提供了多重优势，包括快速起效的同时维持药物释放、延长肿瘤滞留时间以及增强在生物体液中的稳定性。此外，NPs促进了靶向细胞递送，并有助于减轻耐药性[3, 102]。研究表明，一些药物递送系统，如有机基NPs，具有克服p‑糖蛋白介导的外排的潜力，因为它们能够绕过并抑制p‑糖蛋白[103]。 基于这些进展以及个性化医疗日益增长的重视，当前研究聚焦于设计多种类型的纳米颗粒（NPs），以定制治疗方案满足患者个体需求。值得注意的是，以下类型的NPs目前在癌症治疗中展现出最大的临床潜力： 1. 有机纳米颗粒 有机纳米颗粒（NPs）分为脂质基和聚合物基纳米材料，是癌症治疗中最广泛应用的纳米载体之一。脂质基NPs包括多种结构，如脂质体、类脂质体、纳米结构脂质载体、固体脂质NPs和脂质纳米乳剂。相比之下，聚合物NPs则采用合成可生物降解聚合物（如聚乳酸‑羟基乙酸共聚物PLGA、聚乳酸PLA、聚己内酯PCL和聚乙二醇PEG）或天然蛋白质（如明胶和白蛋白）制备[104]。 值得注意的是，多种脂质和聚合物基NPs已获得监管批准，目前用于治疗不同类型的癌症。例如，脂质NPs如Doxil®（聚乙二醇化脂质体阿霉素）和DaunoXome®（非聚乙二醇化脂质体柔红霉素）均用于治疗艾滋病相关的卡波西肉瘤。Myocet®（非聚乙二醇化脂质体阿霉素）是另一例证，在欧洲和加拿大 获批用于转移性乳腺癌治疗[102]。关于聚合物NPs，白蛋白包裹紫杉醇NPs的Abraxane目前已获批用于转移性乳腺癌治疗[44]。这些成功案例凸显了纳米载体在癌症治疗中的重要性，它们能以最小副作用提供更佳疗效。基于这些临床批准的纳米药物，近期研究探索了将重新利用的药物封装入NPs的潜力，强调其可安全、选择性地改善治疗效果。例如，将苯乙肼载入脂质体后，因药物脱靶分布受限而降低全身副作用，同时增强肿瘤渗透性并实现靶向递送[100]。此外，白蛋白NPs封装的非索非那定通过增强渗透滞留（EPR）效应改善递送效率——其小尺寸和肿瘤内滞留时间延长归因于可控药物释放，从而增强抗癌潜力[44]。另有研究表明，玉米醇溶蛋白NPs封装的阿苯达唑具有更高溶解度和生物利用度，从而提升药物疗效[105]。阿苯达唑溶解性增强源于玉米醇溶蛋白疏水区域促进亲脂性药物封装。类似地，玉米醇溶蛋白NPs可通过调节外排泵活性克服癌细胞多药耐药（MDR），进而增强载药NPs的整体抗癌效果[47]。 这些结果表明，纳米载体的物理化学特性，结合集成聚合物的协同效应和增强的药物靶向性，可显著提升老药新用的治疗效果。讨论部分将进一步提供这些应用的具体案例。 2.无机纳米颗粒 当前纳米医学发展的趋势聚焦于将治疗、诊断和靶向能力整合至单一纳米平台[106]。这类“一体化”纳米平台能将分子成像造影剂与治疗剂相结合，实现同步诊断与治疗。该理念催生了纳米诊疗学——单个混合纳米结构即可执行诊断和治疗功能，包括化疗‑光热、化疗‑光动力及光热‑光动力等联合疗法[107]。 在众多纳米材料中，无机纳米颗粒（NPs）因其独特特性（如精准靶向性、热稳定性、特殊光学性质、超小尺寸、大表面积、可控物理形态及磁响应特性）展现出作为抗癌剂，尤其是纳米诊疗剂的巨大潜力。无机NPs主要由金属、金属氧化物、碳基材料和介孔二氧化硅构成，常见实例包括金、银、氧化铁和氧化锌NPs，以及量子点和碳点[106, 108]。NPs的形态对这些性质具有决定性影响——与通常呈球形的有机NPs不同，无机NPs可呈现多孔结构、纳米棒等多种形状[108]。此外，鉴于其潜在毒性，无机NPs常被生物相容性聚合物包覆以提升安全性[108]。值得注意的是，多种无机NPs已被探索用于癌症治疗的纳米诊疗潜力。其中，超顺磁性氧化铁NPs（SPIONs）因其磁热效应（暴露于振荡磁场时产生局部热量）备受关注。由于肿瘤对42–49°C的适度温升耐受性低，这种局部加热可有效诱导癌细胞死亡[109]。将该技术与药物重定位概念相结合，或能通过单一纳米制剂（如ferumoxytol）改善癌症治疗。Ferumoxytol是食品药品监督管理局批准的、右旋糖酐包覆氧化铁核的超小型SPION，原用于治疗美国缺铁性贫血，但最新研究发现其通过铁死亡机制在体外和体内均具抗白血病效果。具体而言，ferumoxytol靶向低表达铁转运蛋白的癌细胞，导致细胞内铁蓄积增加并引发细胞死亡。这种细胞毒性源于NPs组分通过铁物种诱导过量ROS产生，进而引发氧化应激致细胞死亡[110–112]。该药物的作用机制有效针对了癌症特征——凋亡逃逸。 尽管尚未开展针对白血病治疗的临床试验，但菲立磁的应用已超越其抗癌特性。值得注意的是，近期研究探索了菲立磁的诊断潜力，现有临床研究正评估其作为核磁共振（MRI）造影剂的用途，以评估接受放疗和替莫唑胺治疗的胶质母细胞瘤患者的早期肿瘤反应[113]。菲立磁是药物重定位中纳米诊疗制剂的成功范例，同时展现了单一纳米载体内的治疗功效与诊断能力。 总体而言，多年来人们研究了各种类型的纳米颗粒（NPs），以寻找一种兼具良好理化特性、治疗功效和癌症治疗安全性的最优纳米系统。基于这一基础，载药纳米载体与药物重定位技术的结合，辅以对癌症生物学及其独特特征的深入理解，为应对肿瘤学领域的治疗挑战提供了一种前景广阔的策略。本综述重点阐述了当前癌症治疗领域的最新进展，包括应用纳米技术和药物重定位靶向特定癌症通路，以实现有效且精准的肿瘤消除。通过批判性视角，我们评估了不同类型NPs的抗癌特性、靶向机制和理化特征，并对比了多项研究结果。最终，本文献综述旨在通过批判性分析现有文献，重点介绍具有潜力的载药NPs及可能改善癌症治疗效果的潜在治疗策略。 方法 本叙述性综述依据系统综述和荟萃分析优先报告条目（PRISMA）框架指南对所选文章进行分析。首先，检索方法基于对PubMed、ScienceDirect、ClinicalTrials.gov和Google Scholar等电子数据库的搜索。 检索涵盖2010年至2025年的出版物，使用以下关键词：‘药物重定位’、‘纳米颗粒’、‘重定位方法’、‘抗高血压药抗癌’、‘抗糖尿病药抗癌’、‘他汀类抗癌’、‘抗抑郁药抗癌’、‘抗寄生虫药抗癌’、‘癌症特征’、‘纳米颗粒制备’、‘机器学习’和‘人工智能’。相关文章（共172篇，包括研究论文和综述）被下载。使用Mendeley文献管理软件去除重复文章。此外，通过筛选摘要和结论来选取符合综述目的的文章。 纳入标准包含以下内容：• 2018年至2025年间的最新研究文章。• 发表在健康科学与药物创新领域的文章，重点探讨通过药物再利用方法治疗癌症。• 所讨论的药物应整合或与纳米载体联合使用。 • 引言部分收录的文章应介于2010年至2025年间（Hanahan和Weinberg发表的癌症特征研究除外）。 排除标准包括： • 专注于癌症以外其他疾病的研究论文。 • 2010年之前发表的论文。 • 关于未进行药物重定向的传统抗癌药物的研究。 讨论 过去十年间，各类小分子药物被探索其潜在的抗癌效果，包括抗抑郁药、抗组胺药、降压药、降糖药、降脂药及抗寄生虫药。其中部分药物已被报道对多种细胞系具有抗肿瘤作用。本节通过案例研究展示了不同药物（如苯乙肼、非索非那定、氯沙坦、替米沙坦、二甲双胍、卡格列净、阿托伐他汀和芬苯达唑）在实验性药物重定向方法中的最新发现。每个案例均分析了将这些药物封装至不同类型纳米颗粒（NPs）的影响，重点探讨纳米制剂如何增强它们在癌症治疗中的治疗潜力[44, 47, 59, 99,100，114–116]。 参考文献 1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/CAAC.21834. 2. Zhang Z, Zhou L, Xie N, Nice EC, Zhang T, Cui Y, et al. Overcoming cancer therapeutic bottleneck by drug repurposing. Signal Transduct Target Ther. 2020;5:1–25. https://doi.org/10.1038/s41392-020-00213-8. 3. Bhatia S. Nanoparticles types, classification, characterization,fabrication methods and drug delivery applications. In: Natural Polymer Drug Delivery Systems. Springer, Cham. 2016. https://doi.org/10.1007/978-3-319-41129-3_2. 4. Singh N, Baby D, Rajguru J, Patil P, Thakkannavar S, Pujari V. Inflammation and cancer. Ann Afr Med. 2019;18:121. https://doi.org/10.4103/AAM.AAM_56_18. 5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70. https://doi.org/10.1016/s0092-8674(00)81683-9. 6. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74. https://doi.org/10.1016/j.cell.2011.02.013. 7. Sadeghi Rad H, Monkman J, Warkiani ME, Ladwa R, O’Byrne K, Rezaei N, et al. Understanding the tumor microenvironment for effective immunotherapy. Med Res Rev. 2021;41:1474–98.https://doi.org/10.1002/med.21765. 8. Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252. https://doi.org/10.1038/NRC3239. 9. Hanahan D. Hallmarks of cancer: New dimensions. Cancer Discov. 2022;12:31–46. https://doi.org/10.1158/2159-8290.CD-21-1059. 10. Yuan S, Norgard RJ, Stanger BZ. Cellular plasticity in cancer. Cancer Discov. 2019;9:837. https://doi.org/10.1158/2159-8290.CD-19-0015. 11. Torborg SR, Li Z, Chan JE, Tammela T. Cellular and molecular mechanisms of plasticity in cancer. Trends Cancer. 2022;8:735.https://doi.org/10.1016/J.TRECAN.2022.04.007. 12. Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, et al. Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets. Signal Transduct Target Ther. 2024;9:1–36. https://doi.org/10.1038/s41392-024-01848-7. 13. Piktel E, Niemirowicz K, Watek M, Wollny T, Deptuła P, Bucki R. Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy. J Nanobiotechnol. 2016;14:1–23. https://doi.org/10.1186/S12951-016-0193-X. 14. Van den Boogaard WMC, Komninos DSJ, Vermeij WP. Chemotherapy side-effects: not all DNA damage is equal. Cancers. 2022;14:627. https://doi.org/10.3390/CANCERS14030627. 15. Bukowski K, Kciuk M, Kontek R. Mechanisms of multidrug resistance in cancer chemotherapy. Int J Mol Sci. 2020;21:3233.https://doi.org/10.3390/IJMS21093233. 16. Wang H, Li X, Chen T, Wang W, Liu Q, Li H, et al. Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation. Oncol Rep. 2013;29:676–84. https://doi.org/10.3892/or.2012.2156. 17. Zheng W, Li M, Lin Y, Zhan X. Encapsulation of verapamil and doxorubicin by MPEG-PLA to reverse drug resistance in ovarian cancer. Biomed Pharmacother. 2018;108:565–73. https://doi.org/10.1016/J.BIOPHA.2018.09.039. 18. Sarisozen C, Vural I, Levchenko T, Hincal AA, Torchilin VP. PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells. Drug Deliv. 2012;19:169–76. https://doi.org/10.3109/10717544.2012.674163. 19. Liao YQ, Fang BB, Wu QX, Dong WY, Deng GM. Verapamil modulates NFAT2 to inhibit tumor growth and potentiates PD1ab immune checkpoint inhibitor therapy in cervical cancer treatment. J Signal Transduct. 2023;43:93–101. https://doi.org/10.1080/10799893.2023.2291562. 20. Chen YC, Wu CT, Chen JH, Tsai CF, Wu CY, Chang PC, et al. Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition. Oncogenesis. 2022;11:1–9. https://doi.org/10.1038/s41389-022-00423-5. 21. Hermawan A, Putri H, Utomo RY. Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy. DARU J Pharm Sci. 2020;28:685–99. https://doi.org/10.1007/s40199-020-00375-4. 22. Yang S, Li Z, Yi J, Pan M, Cao W, Ma J, et al. Nebivolol, an antihypertensive agent, has new application in inhibiting melanoma. Anticancer Drugs. 2024;35:512–24. https://doi.org/10.1097/CAD.0000000000001597. 23. Dezong G, Zhongbing M, Qinye F, Zhigang Y. Carvedilol suppresses migration and invasion of malignant breast cells by inactivating Src involving camp/PKA and pkcδ signaling pathway. J Cancer Res Ther. 2014;10:991–7. https://doi.org/10.4103/0973-1482.137664. 24. Koh M, Takahashi T, Kurokawa Y, Kobayashi T, Saito T, Ishida T, et al. Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis. Gastric Cancer. 2021;24:1037–49. https://doi.org/10.1007/s10120-021-01184-7. 25. Terzi MY, Urhan-Kucuk M. Anti-proliferative effects of betablocker propranolol on human lung cancer and noncancer cells. Bratisl med j. 2023;124:292–303. https://doi.org/10.4149/BLL_2023_045. 26. Tamim YM, Nagy AA, Abdellah AM, Osman AH, Ismail AFM. Anticancer effect of propranolol on diethylnitrosamine-induced hepatocellular carcinoma rat model. Fundam Clin Pharmacol. 2024;38:742–57. https://doi.org/10.1111/FCP.12990. 27. Wang F, Liu H, Wang F, Xu R, Wang P, Tang F, et al. Propranolol suppresses the proliferation and induces the apoptosis of liver cancer cells. Mol Med Rep. 2018;17:5213–21. https://doi.org/10.3892/mmr.2018.8476. 28. Alqudah MAY, Al-Samman R, Azaizeh M, Alzoubi KH. Amlodipine inhibits proliferation, invasion, and colony formation of breast cancer cells. Biomed Rep. 2022;16:50. https://doi.org/10.3892/BR.2022.1533. 29. Chen YM, Yang WQ, Gu CW, Fan YY, Liu YZ, Zhao BS. Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress. World J Gastroenterol. 2024;30:367. https://doi.org/10.3748/WJG.V30.I4.367. 30. Fu B, Dou X, Zou M, Lu H, Wang K, Liu Q, et al. Anticancer effects of amlodipine alone or in combination with gefitinib in non-small cell lung cancer. Front Pharmacol. 2022;13:902305. https://doi.org/10.3389/fphar.2022.902305. 31. Huang W, Yang S, Deng M, Luo R, Liang H, Shen Y, et al. Amlodipine inhibits Synaptotagmin-4’s oncogenic activity on gastric cancer proliferation by targeting calcium signaling. Funct Integr Genomics. 2024;24:1–14. https://doi.org/10.1007/s10142-024-01345-8. 32. Hashemzehi M, Rahmani F, Khoshakhlagh M, Avan A, Asgharzadeh F, Barneh F, et al. Angiotensin receptor blocker losartan inhibits tumor growth of colorectal cancer. EXCLI J. 2021;20:506. https://doi.org/10.17179/EXCLI2020-3083. 33. Chang YL, Chou CH, Li YF, Huang LC, Kao Y, Hueng DY, et al. Antiproliferative and apoptotic effects of telmisartan in human glioma cells. Cancer Cell Int. 2023;23:1–16. https://doi.org/10.1186/s12935-023-02963-1. 34. Marinov L, Georgieva A, Toshkova R, Kostadinova I, Mangarov I, Toshkova-Yotova T. The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines. Pharmacia. 2024;71:1–12. https://doi.org/10.3897/PHARMACIA.71.E113677. 35. Akrami H, Aminzadeh S, Fallahi H. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumor Biol. 2015;36:3237–43. https://doi.org/10.1007/ s13277-014-2952-3. 36. Da Silveira EF, Chassot JM, Teixeira FC, Azambuja JH, Debom G, Beira FT, et al. Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme. Invest New Drugs. 2013;31:1424–35. https://doi.org/10.1007/s10637-013-0016-y. 37. Patra I, Naser RH, Hussam F, Hameed NM, Kadhim MM, Ahmad I, et al. Ketoprofen suppresses triple negative breast cancer cell growth by inducing apoptosis and inhibiting autophagy. Mol Biol Rep. 2023;50:85–95. https://doi.org/10.1007/s11033-022-07921-0. 38. Yang L, Li J, Li Y, Zhou Y, Wang Z, Zhang D, et al. Diclofenac impairs the proliferation and glucose metabolism of triple-negative breast cancer cells by targeting the c-Myc pathway. Exp Ther Med. 2021;21:584. https://doi.org/10.3892/ETM.2021.10016. 39. Medeiros HCD, Colturato-Kido C, Ferraz LS, Costa CA, Moraes VWR, Paredes-Gamero EJ, et al. AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020;315:108888. https://doi.org/10.1016/J.CBI.2019.108888. 40. Liu X, Zhong R, Huang J, Chen Z, Xu H, Lin L, et al. Loratidine is associated with improved prognosis and exerts antineoplastic effects via apoptotic and pyroptotic crosstalk in lung cancer. J Exp Clin Cancer Res. 2024;43:1–13. https://doi.org/10.1186/s13046-023-02914-8. 41. Chien MH, Hung WY, Lai TC, Tsai CH, Lee KL, Hsieh FK, et al. The off-target effect of loratadine triggers autophagy-mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A-dependent and independent pathways. Int J Mol Med. 2025;55:1–17. https://doi.org/10.3892/IJMM.2025.5495/HTML. 42. Toriyama K, Okuma T, Abe S, Nakamura H, Aoshiba K. In vitro anticancer effect of azithromycin targeting hypoxic lung cancer cells via the inhibition of mitophagy. Oncol Lett. 2023. https://doi.org/10.3892/OL.2023.14146. 43. De Guadalupe Chávez-López M, Hernández-Gallegos E, Vázquez-Sánchez AY, Gariglio P, Camacho J. Antiproliferative and proapoptotic effects of astemizole on cervical cancer cells. Int J Gynecol Cancer. 2014;24(5):824–8. https://doi.org/10.1097/IGC.0000000000000151. 44. Lai X, Yao F, An Y, Li X, Da YX. Novel nanotherapeutics for cancer immunotherapy by PD-L1-aptamer-functionalized and fexofenadine-loaded albumin nanoparticles. Molecules. 2023;28:2556. https://doi.org/10.3390/MOLECULES28062556. 45. Wang WT, Chen YH, Hsu JL, Leu WJ, Yu CC, Chan SH, et al. Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:33–45.https://doi.org/10.1007/s00210-013-0912-x. 46. Trybus E, Król T, Trybus W. The multidirectional effect of azelastine hydrochloride on cervical cancer cells. Int J Mol Sci. 2022;23:5890. https://doi.org/10.3390/IJMS23115890. 47. Elmahboub Y, Albash R, Magdy William M, Rayan AH, Hamed NO, Ousman MS, et al. Metformin loaded zein polymeric nanoparticles to augment antitumor activity against Ehrlich carcinoma via activation of AMPK pathway: d-optimal design optimization, in vitro characterization, and in vivo study. Molecules. 2024;29:1614. https://doi.org/10.3390/MOLECULES29071614. 48. Courtois S, Lehours P, Bessède E. The therapeutic potential of metformin in gastric cancer. Gastric Cancer. 2019;22:653–62.https://doi.org/10.1007/s10120-019-00952-w. 49. Wu B, Li S, Sheng L, Zhu J, Gu L, Shen H, et al. Metformin inhibits the development and metastasis of ovarian cancer. Oncol Rep. 2012;28:903–8. https://doi.org/10.3892/or.2012.1890. 50. Park D, Lee JH, Yoon SP. Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells. Korean J Physiol Pharmacol. 2022;26:377. https://doi.org/10.4196/KJPP.2022.26.5.377. 51. Castro LSEPW, Kviecinski MR, Ourique F, Parisotto EB, Grinevicius VMAS, Correia JFG, et al. Albendazole as a promising molecule for tumor control. Redox Biol. 2016;10:90–9. https:// doi.org/10.1016/J.REDOX.2016.09.013. 52. Gupta R, Roy D, Ghosh A, Begum Y, Ghosh D, Swarnakar S. Mebendazole exerts anticancer activity in ovarian cancer cell lines via novel girdin-mediated AKT/ikkα/β/NF-κb signaling axis. Cells. 2025;14:113. https://doi.org/10.3390/cells14020113. 53. Gross ME, Agus DB, Dorff TB, Pinski JK, Quinn DI, Castellanos O, et al. Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer Prostatic Dis. 2021;24:61–8. https://doi.org/10.1038/s41391-020-0211-9. 54. Yan S, Yang X, Chen T, Xi Z, Jiang X. The PPARγ agonist troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Cancer Gene Ther. 2014;21:188–93. https://doi.org/10.1038/cgt.2014.16. 55. Fujita M, Hasegawa A, Yamamori M, Okamura N. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017;36:1–9. https://doi.org/10.1186/ s13046-017-0557-6. 56. Li G, Zheng J, Xu B, Ling J, Qiu W, Wang Y. Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer. Biomed Pharmacother. 2017;85:418–24. https://doi.org/10.1016/J.BIOPHA.2016.11.045. 57. Wang T, Seah S, Loh X, Chan CW, Hartman M, Goh BC, et al. Simvastatin-induced breast cancer cell death and deactivation of PI3K/AKTand MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. Oncotarget. 2015;7:2532. https://doi.org/10.18632/ONCOTARGET.6304. 58. Hu MB, Zhang JW, Gao JB, Qi YW, Gao Y, Xu L, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018;42:409–15. https://doi.org/10.1080/01913123.2018.1522406. 59. Gaber DM, Ibrahim SS, Awaad AK, Shahine YM, Elmallah S, Barakat HS, et al. A drug repurposing approach of Atorvastatin calcium for its antiproliferative activity for effective treatment of breast cancer: in vitro and in vivo assessment. Int J Pharm: X. 2024;7:100249. https://doi.org/10.1016/J.IJPX.2024.100249. 60. Niclosamide in Pediatric Patients With Relapsed and Refractory AML. Clinicaltrials.gov. 2025.https://clinicaltrials.gov/study/NCT05188170?Cond=Cancer&intr=Niclosamide&rank=3. Accessed 10 July 2025. 61. Li Y, Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ. Multi-targeted therapy of cancer by niclosamide: a new application for an old drug. Cancer Lett. 2014;349:8. https://doi.org/10.1016/J.CANLET.2014.04.003. 62. Wang Z, Ren J, Du J, Wang H, Liu J, Wang G. Niclosamide as a promising therapeutic player in human cancer and other diseases. Int J Mol Sci. 2022;23:16116. https://doi.org/10.3390/IJMS232416116. 63. Evaluating the effect of itraconazole on pathologic complete response rates in esophageal cancer. Clinicaltrials.gov. 2021.https://clinicaltrials.gov/study/NCT04018872?Cond=Cancer%20&intr=Itraconazole%20&aggfilters=status:act%20not%20rec&rank=3. Accessed 11 July 2025. 64. A Study of Propranolol to Treat Kaposi Sarcoma. Clinicaltrials.gov. 2025. https://clinicaltrials.gov/study/NCT05797662?Cond=Cancer&intr=Propranolol%20Hydrochloride&rank=22.Accessed 10 July 2025. 65. Mcallister SC, Hanson RS, Manion RD. Propranolol decreases proliferation of endothelial cells transformed by Kaposi’s sarcoma-associated herpesvirus and induces lytic viral gene expression. J Virol. 2015;89:11144. https://doi.org/10.1128/JVI.01569-15. 66. Calcium channel blocker amlodipine for endometrial cancer therapy. Clinicaltrials.gov. 2025. https://clinicaltrials.gov/study/NCT06942377?Cond=Cancer&intr=Amlodipine&limit=100&rank=1. Accessed 10 July 2025. 67. Wu TTL, Niu HS, Chen LJ, Cheng JT, Tong YC. Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. Eur J Pharmacol. 2016;775:35–42.https://doi.org/10.1016/j.ejphar.2016.02.017. 68. Telmisartan in prostate cancer. Clinicaltrials.gov. 2024. https://clinicaltrials.gov/study/NCT06168487?Cond=Cancer&intr=Telmisartan&limit=100&rank=3. Accessed 10 July 2025. 69. Mebendazole as adjuvant treatment for colon cancer. Clinicaltrials.gov. 2019. https://clinicaltrials.gov/study/NCT03925662?Cond=Cancer&intr=Mebendazole&rank=3. Accessed 10 July 2025. 70. Hegazy SK, El-Azab GA, Zakaria F, Mostafa MF, El-Ghoneimy RA. Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer. Life Sci.2022;299:120536. https://doi.org/10.1016/J.LFS.2022.120536. 71. Diclofenac for the treatment of patients with metastatic non-small cell lung cancer on single agent immunotherapy. Clinicaltrials. gov. 2025. https://clinicaltrials.gov/study/NCT06731270?Cond=Cancer&intr=Diclofenac&limit=100&rank=30. Accessed 10 July 2025. 72. Amanullah A, Upadhyay A, Dhiman R, Singh S, Kumar A, Kumar Ahirwar D, et al. Development and challenges of diclofenac-based novel therapeutics: targeting cancer and complex diseases. Cancers. 2022. https://doi.org/10.3390/cancers14184385. 73. Phase 2, open-label, single-arm study on the use of metformin as adjunctive therapy in high-grade glioma. Clinicaltrials.gov. 2023. https://clinicaltrials.gov/study/NCT05929495?Cond=Cancer%20&intr=Metformin&rank=3. Accessed 10 July 2025. 74. Metformin as a metabolic intervention in oesophageal adenocarcinomas to improve response to neoadjuvant chemoradiotherapy. Clinicaltrials.gov. 2025. https://clinicaltrials.gov/study/NCT06687876?Cond=Cancer%20&intr=Metformin&rank=12 .Accessed 10 July 2025. 75. Basheer HA, Salman NM, Abdullah RM, Elsalem L, Afarinkia K. Metformin and glioma: targeting metabolic dysregulation for enhanced therapeutic outcomes. Transl Oncol. 2025;53:102323.https://doi.org/10.1016/J.TRANON.2025.102323. 76. Alrosan AZ, Heilat GB, Al Subeh ZY, Alrosan K, Alrousan AF, Abu-Safieh AK, et al. The effects of statin therapy on brain tumors, particularly glioma: a review. Anticancer Drugs. 2023;34:985. https://doi.org/10.1097/CAD.0000000000001533. 77. Evaluate the efficacy and safety of atorvastatin combined with temozolomide in the treatment of glioblastoma. Clinicaltrials. gov. 2024. https://clinicaltrials.gov/study/NCT06327451?Cond=Glioblastoma&intr=Atorvastatin&limit=100&rank=2. Accessed 11 July 2025. 78. Clinical study evaluating the effect of losartan. Clinicaltrials. gov. 2024 https://clinicaltrials.gov/study/NCT06539806?Cond=Cancer&intr=Losartan%20&limit=100&rank=4#study-overview.Accessed 10 July 2025. 79. Phase IB metformin, digoxin, simvastatin in solid tumors. Clinicaltrials.gov. 2024. https://clinicaltrials.gov/study/NCT03889795?Cond=Cancer%20&intr=Simvastatin&aggfilters=status:act%20not%20rec&rank=1.Accessed 11 July 2025. 80. Abiraterone acetate, niclosamide, and prednisone in treating patients with hormone-resistant prostate cancer. Clinicaltrials. gov. 2024. https://clinicaltrials.gov/study/NCT02807805?Cond=Cancer&intr=Niclosamide&rank=6.Accessed 10 July 2025. 81. Propranolol hydrochloride in combination with sintilimab and platinum-based chemotherapy for treatment of advanced nonsmall cell lung cancer. Clinicaltrials.gov. 2024. https://clinicaltrials.gov/study/NCT05979818?Cond=Cancer&intr=Propranolol&limit=50&rank=12.Accessed 10 July 2025. 82. PHL treatment in pancreatic cancer. Clinicaltrials.gov. 2025.https://clinicaltrials.gov/study/NCT05365893?Cond=Cancer&intr=Losartan%20&limit=100&rank=24. Accessed 10 July 2025. 83. Jarada TN, Rokne JG, Alhajj R. A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions. J Cheminform. 2020;12:1–23. https:// doi.org/10.1186/S13321-020-00450-7. 84. Parvathaneni V, Kulkarni NS, Muth A, Gupta V. Drug repurposing: a promising tool to accelerate the drug discovery process. Drug Discov Today. 2019;24:2076–85. https://doi.org/10.1016/J.DRUDIS.2019.06.014. 85. Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, et al. The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. J Biol Chem. 2021;298:101531. https://doi.org/10. 1016/J.JBC.2021.101531. 86. Selvin T, Berglund M, Lenhammar L, Jarvius M, Nygren P, Fryknäs M, et al. Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death. BMC Cancer. 2023;23:1–10. https://doi.org/10.1186/s12885-023-10645-4. 87. Meera M, Sekar S, Mahatao R. A novel approach for drug discovery-drug repurposing. Natl J Physiol Pharm Pharmacol. 2022;12:1. https://doi.org/10.5455/njppp.2022.12.03127202230032022. 88. Jabarin A, Shtar G, Feinshtein V, Mazuz E, Shapira B, BenShabat S, et al. Eravacycline, an antibacterial drug, repurposed for pancreatic cancer therapy: insights from a molecular-based deep learning model. Brief Bioinform. 2024. https://doi.org/10.1093/BIB/BBAE108. 89. Wieder R, Adam N. Drug repositioning for cancer in the era of AI, big omics, and real-world data. Crit Rev Oncol Hematol. 2022;175. https://doi.org/10.1016/J.CRITREVONC.2022. 103730. 90. Gilson MK, Liu T, Baitaluk M, Nicola G, Hwang L, Chong J. Bindingdb in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology. Nucleic Acids Res. 2016;44:D1045–53. https://doi.org/10.1093/NAR/GKV1072. 91. Cheng T, Pan Y, Hao M, Wang Y, Bryant SH. Pubchem applications in drug discovery: a bibliometric analysis. Drug Discov Today. 2014;19:1751. https://doi.org/10.1016/J.DRUDIS.2014.08.008. 92. Park K. A review of computational drug repurposing. Transl Clin Pharmacol. 2019;27:59. https://doi.org/10.12793/TCP.2019.27.2.59. 93. Somadder PD, Hossain MA, Ahsan A, Sultana T, Soikot SH, Rahman MM, et al. Drug repurposing and systems biology approaches of enzastaurin can target potential biomarkers and critical pathways in colorectal cancer. Comput Biol Med. 2023;155:106630. https://doi.org/10.1016/J.COMPBIOMED.2023.106630. 94. Malla RR, Viswanathan S, Makena S, Kapoor S, Verma D, Raju AA, et al. Revitalizing cancer treatment: exploring the role of drug repurposing. Cancers. 2024;16:1463. https://doi.org/10. 3390/CANCERS16081463. 95. Corsello SM, Nagari RT, Spangler RD, Rossen J, Kocak M, Bryan JG, et al. Discovering the anticancer potential of nononcology drugs by systematic viability profiling. Nat Cancer. 2020;1:235–48. https://doi.org/10.1038/s43018-019-0018-6. 96. Ramesh P, Karuppasamy R, Veerappapillai S. Machine learning driven drug repurposing strategy for identification of potential RET inhibitors against non-small cell lung cancer. Med Onco. 2023;40:1–18. https://doi.org/10.1007/s12032-022-01924-4. 97. Raju B, Verma H, Narendra G, Sapra B, Silakari O. Multiple machine learning, molecular docking, and ADMET screening approach for identification of selective inhibitors of CYP1B1. J Biomol Struct Dyn. 2022;40:7975–90. https://doi.org/10.1080/07391102.2021.1905552. 98. Tanoli Z, Vähä-Koskela M, Aittokallio T. Artificial intelligence, machine learning, and drug repurposing in cancer. Expert Opin Drug Discov. 2021;16:977–89. https://doi.org/10.1080/17460441.2021.1883585. 99. Dhavale RP, Dhavale RP, Sahoo SC, Kollu P, Jadhav SU, Patil PS, et al. Chitosan coated magnetic nanoparticles as carriers of anticancer drug telmisartan: pH-responsive controlled drug release and cytotoxicity studies. J Phys Chem Solids. 2021. https://doi.org/10.1016/j.jpcs.2020.109749. 100. Brown J, Li Z, Wang X, Kim YJ, Wang YC, Zuo Y, et al. Nanoformulation improves antitumor efficacy of MAOI immune checkpoint blockade therapy without causing aggressionrelated side effects. Front Pharmacol. 2022;13:970324. https://doi.org/10.3389/fphar.2022.970324. 101. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16:1–33. https://doi.org/10.1186/S12951-018-0392-8. 102. Pucci C, Martinelli C, Ciofani G. Innovative approaches for cancer treatment: current perspectives and new challenges. Ecancermedicalscience. 2019;13:961. https://doi.org/10.3332/ECANCER.2019.961. 103. Nguyen TTL, Duong VA, Maeng HJ. Pharmaceutical formulations with p-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability. Pharmaceutics. 2021;13:1103. https://doi.org/10.3390/PHARMACEUTICS13071103. 104. Vieira IRS, Tessaro L, Lima AKO, Velloso IPS, Conte-Junior CA. Recent progress in nanotechnology improving the therapeutic potential of polyphenols for cancer. Nutrients. 2023;15:3136. https://doi.org/10.3390/NU15143136. 105. Mneimneh AT, Hayar B, Al Hadeethi S, Darwiche N, Mehanna MM. Application of Box-Behnken design in the optimization and development of albendazole-loaded zein nanoparticles as a drug repurposing approach for colorectal cancer management. Int J Biol Macromol. 2024;281:136437. https://doi.org/10.1016/J.IJBIOMAC.2024.136437. 106. Narayana S, Gowda BHJ, Hani U, Shimu SS, Paul K, Das A, et al. Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges. J Nanobiotechnol. 2024;22:1–25. https://doi.org/10.1186/s12951-024-02701-3. 107. Prasad R, Selvaraj K. Choice of nanoparticles for theranostics engineering: surface coating to nanovalves approach. Nanotheranostics. 2024;8:12. https://doi.org/10.7150/NTNO.89768. 108. Dennahy IS, Han Z, Maccuaig WM, Chalfant HM, Condacse A, Hagood JM, et al. Nanotheranostics for image-guided cancer treatment. Pharmaceutics. 2022;14:917. https://doi.org/10.3390/PHARMACEUTICS14050917. 109. Vangijzegem T, Lecomte V, Ternad I, Van Leuven L, Muller RN, Stanicki D, et al. Superparamagnetic iron oxide nanoparticles (SPION): from fundamentals to state-of-the-art innovative applications for cancer therapy. Pharmaceutics. 2023;15:236. https://doi.org/10.3390/PHARMACEUTICS15010236. 110. Su Y, Zhao B, Zhou L, Zhang Z, Shen Y, Lv H, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020;483:127–36. https://doi.org/10.1016/j.canlet.2020.02.015. 111. Trujillo-Alonso V, Pratt EC, Zong H, Lara-Martinez A, Kaittanis C, Rabie MO, et al. FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels. Nat Nanotechnol. 2019;14:616. https://doi.org/10.1038/S41565-019-0406-1. 112. Finn JP, Nguyen KL, Han F, Zhou Z, Salusky I, Ayad I, et al. Cardiovascular MRI with ferumoxytol. Clin Radiol. 2016;71:796–806. https://doi.org/10.1016/j.crad.2016.03.020. 113. Pandey N, Anastasiadis P, Carney CP, Kanvinde PP, Woodworth GF, Winkles JA, et al. Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment. Adv Drug Deliv Rev. 2022;188:114415. https://doi.org/10.1016/J.ADDR.2022.114415. 114. Zhang X, Zhao Y, Teng Z, Sun T, Tao J, Wu J, et al. Combination of losartan and platinum nanoparticles with photothermal therapy induces immunogenic cell death effective against neuroblastoma. Int J Nanomedicine. 2024;19:10213–26. https://doi.org/10.2147/IJN.S467968. 115. Wang S, Sui M, Chen Q, Guo J, Yang H, Zhou Y, et al. Engineering PD-L1 targeted liposomal canagliflozin achieves multimodal synergistic cancer therapy. Chem Eng J. 2024;498:155074.https://doi.org/10.1016/J.CEJ.2024.155074. 116. Esfahani MKM, Alavi SE, Cabot PJ, Islam N, Izake EL. Β-lactoglobulin-modified mesoporous silica nanoparticles: a promising carrier for the targeted delivery of fenbendazole into prostate cancer cells. Pharmaceutics. 2022;14:884. https://doi.org/10.3390/pharmaceutics14040884.  ✦  关于我们 江苏百奥信康医药科技有限公司是一家以新药研发驱动制药全产业链发展的高科技创新型医药企业。公司以研发自我持有的改良型新药和高端特色仿制药产品为主业，构建核心技术平台，同时为国内外客户提供新药和仿制药产品的研发服务。 版权及免责声明 「百奥信康」公众号推送的内容来源于原创或根据公开资料整理编辑，欢迎个人转发至朋友圈。媒体或机构如需转载，请完整注明：本文转载自百奥信康公众号（ID: BioScenePharma）；作者栏请填写：百奥信康；并插入百奥信康公众号链接。 本公众号的目的在于分享行业相关知识、传递最新医药资讯。如有侵权，请在留言栏及时告知，我们将及时删除相关信息。本公众号推送的文章中的观点不代表百奥信康的立场，也不是治疗方案的推荐。如需获得诊断或治疗方面的指导，请前往正规医院就诊。

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至12月13日15点59分，近期共有 516 本期刊发布了 1042 篇文章，其中糖尿病相关的文章共 423 篇，覆盖 36 个领域的内容。中国专家参与发表的文章有 133 篇。今日，影响因子最高的文章刊登在 Nature medicine (IF: 50.000) 期刊上。 今日头条 Headlines 01 Int J Biol Macromol IF: 08.500 自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合 Xiao, Zhenyong, Zhao, Hu, Yu, Qiuyi, Luo, Hanwen, Liu, Yan, Liu, Ziying, etc. 糖尿病引起的慢性伤口，因其复杂的病理环境，如持续炎症、易发感染和血管生成障碍，一直是临床治疗中的巨大挑战。近日，一项发表在《International journal of biological macromolecules》上的研究，为这一难题带来了新的解决方案。由研究人员Xiao Zhenyong、Zhao Hu、Yu Qiuyi、Luo Hanwen、Liu Yan、Liu Ziying、Xie Xiangtao和Liu Bo共同完成的研究，成功开发出一种名为PCCCu的多功能自适应可注射水凝胶，该水凝胶在实验中展现出加速糖尿病伤口愈合的显著效果。 该研究的核心是一种创新的水凝胶材料。研究人员将氧化普鲁兰糖与羧甲基壳聚糖（CMCS)通过动态的希夫碱反应进行交联，构建了一个灵活的网络结构。在此基础上，他们进一步将具有抗炎活性的姜黄素和具有抗菌潜力的氧化铜纳米颗粒整合到网络中，最终形成了PCCCu水凝胶。这种设计使得水凝胶不仅具备可注射性，能够轻松填充和贴合不规则的伤口创面，还赋予了其结构上的稳定性，为伤口提供了理想的物理屏障和药物递送平台。 为了全面评估PCCCu水凝胶的效能，研究团队进行了一系列严谨的体外实验。结果显示，该水凝胶具有良好的生物相容性，其溶血率低于5%，表明其对血液细胞的安全性。在对抗细菌感染方面，PCCCu水凝胶表现突出，其抗菌率超过90%，为伤口免受感染提供了有力保障。此外，实验还证实该水凝胶具备强大的促血管生成能力，并能通过调节巨噬细胞极化来调控炎症反应，这恰恰针对了糖尿病伤口愈合过程中炎症失控和血管新生不足的核心问题。 研究的最终验证在糖尿病大鼠模型中进行。动物实验的结果令人鼓舞，应用了PCCCu水凝胶的糖尿病伤口，其愈合过程被显著加速。组织学分析进一步揭示了其作用的深层机制：水凝胶处理后的伤口，上皮化进程更快，新生肉芽组织更丰富，血管再生更为活跃，并且胶原纤维的排列也更趋有序和成熟。这些微观层面的改善，共同促成了宏观上伤口更快更好地闭合。 综上所述，这项研究开发的PCCCu自适应可注射水凝胶，通过其抗菌、促血管生成和免疫调节的多重协同作用，在实验模型中有效促进了糖尿病伤口的愈合。该成果为开发新型糖尿病伤口敷料提供了有价值的思路和实验依据。 本文由 丁克芳 编辑 扫描二维码查看源文 Int J Biol Macromol | Ahead of Print. 10.1016/j.ijbiomac.2025.149616 02 Diabetes Res Clin Pract IF: 07.400 动态血糖监测在临床实践中对使用胰岛素方案的2型糖尿病患者的效用：病例系列与专家意见 一项聚焦于动态血糖监测技术临床应用的最新综述与专家意见，为使用胰岛素治疗的2型糖尿病患者的精准管理提供了实用指引。这项工作的核心在于，针对亚洲地区相关临床指导相对缺乏的现状，通过结合真实病例与专家分析，旨在帮助临床医生更有效地利用这一技术。 该文章明确指出，对于依赖胰岛素的2型糖尿病患者，动态血糖监测能够提供传统指尖血糖检测难以获取的连续血糖信息，清晰揭示患者全天的血糖波动模式。这不仅有助于医生精细化调整胰岛素剂量和用药方案，还能为患者选择饮食、运动等生活方式提供直观依据，同时免去了频繁扎手指带来的痛苦与不便。 值得关注的是，文章特别区分了三种常见的临床场景进行深入探讨。首先是身体状况相对简单、没有其他严重合并症的患者；其次是同时伴有高血压、血脂异常等心血管疾病风险因素的患者；第三则是需要特别关注的老年糖尿病患者群体。针对每一类人群，动态血糖监测的应用重点和考量均有不同。 为了将理论转化为实践，文中精心展示了五个经过匿名处理的真实临床病例。这些案例均附有详细的动态葡萄糖图谱，生动演示了如何解读数据，并基于数据发现的问题来调整治疗策略，从而改善患者的血糖控制结局。这些来自临床一线的实例，为同行提供了极具参考价值的操作范本。 基于病例分析与现有文献依据，专家们系统阐述了动态血糖监测在上述不同患者群体中能够带来的多重获益。其价值不仅局限于优化降糖效果，更延伸到通过预防和及时处理低血糖事件来提升治疗安全性，并最终改善患者的治疗体验与长期生活质量。 综合所有讨论，文章的最终产出是一份包含十项要点的核心临床实践建议清单。这些建议旨在全方位指导临床工作者，更科学地运用动态血糖监测技术，以实现个体化的血糖控制目标，优化胰岛素治疗方案，增强患者对健康生活方式的执行力，最大程度降低低血糖风险，从而全面守护患者的健康与福祉。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Diabetes Res Clin Pract | Ahead of Print. 10.1016/j.diabres.2025.113054 03 Drug delivery IF: 08.100 无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析 Wang, Jing, Chen, Xinhao, Ge, Zhili, Xia, Yingran, Tang, Zixiang, Sun, Zehao, etc. 一项近期发表于《Drug delivery》期刊的全面荟萃分析，为糖尿病患者的胰岛素注射方式提供了新的循证依据。该研究系统比较了无针注射器与传统胰岛素笔在治疗效果、安全性和患者感受方面的差异。 这项研究由Wang Jing, Chen Xinhao等多位研究者共同完成。为了获得可靠的结论，研究团队系统检索了截至2024年6月，发表在CNKI、Weipu、PubMed等多个主流中英文数据库中的相关随机对照试验。最终，共计22项符合标准的研究被纳入分析，这些研究共涉及2580名糖尿病患者，其中使用无针注射器与胰岛素笔的患者各占一半，均为1290名。 分析结果显示，在控制血糖的核心指标上，无针注射器展现出了一定优势。与使用胰岛素笔的患者相比，使用无针注射器的患者其糖化血红蛋白、空腹血糖以及餐后2小时血糖的下降程度更为显著。这表明，在改善血糖水平方面，无针注射器可能是一种更有效的给药工具。 在安全性方面，研究评估了局部和全身两种类型的风险。在注射局部，无针注射器相关的皮肤不良反应发生率更低。而在全身性风险方面，最为患者关注的低血糖事件，其发生率在两组之间并无统计学上的显著差异，提示两种注射方式的系统性安全风险可能相近。 除了客观的临床指标，研究还关注了患者的主观体验。分析发现，患者对无针注射器的接受度和满意度普遍高于传统的胰岛素笔。这提示，减少或避免针头使用可能从心理和使用感受层面改善患者的治疗体验。 然而，研究也指出了一些未观察到显著差异的领域。例如，在反映日内血糖波动的持续血糖监测相关指标上，两种注射方式并未体现出明显区别。研究者表示，这意味着无针注射器对血糖稳定性的长期影响，仍需更多研究来明确。 综合来看，这项荟萃分析表明，对于需要胰岛素治疗的糖尿病患者，无针注射器在改善部分关键血糖指标、减少局部皮肤反应以及提升患者治疗体验方面可能优于传统胰岛素笔。研究结果为临床选择个体化的胰岛素注射方式提供了参考，但研究者也强调，其长期疗效和安全性仍有待进一步验证。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Drug delivery | Volume 32, Issue 1 10.1080/10717544.2025.2597906 04 Hepatobiliary Surg Nutr IF: 07.800 评估2型糖尿病中代谢功能障碍相关脂肪性肝病的风险：Fibrosis-4指数仍是可靠工具吗？ Yoneda, Masato, Kobayashi, Takashi, Iwaki, Michihiro, Wada, Naohiro, Nogami, Asako, Nakajima, Atsushi, etc. 近期发表于《Clinical and Molecular Hepatology》的一项重磅荟萃分析，对广泛应用于肝纤维化评估的FIB-4指数在2型糖尿病（T2DM）人群中的可靠性提出了重要质疑。该研究由Han等人完成，系统评估了FIB-4在鉴别T2DM合并代谢功能障碍相关脂肪性肝病（MASLD）患者晚期肝纤维化方面的诊断性能。 研究发现，当使用临床常用的FIB-4低阈值（1.3至1.67）进行筛查时，其排除晚期纤维化的能力——即阴性预测值（NPV）仅为0.82。这一数值低于通常认为足以确保临床信心的0.90门槛。这意味着，即使在FIB-4评分被认为是“低风险”的T2DM患者中，仍有相当一部分人可能实际存在需要关注的晚期肝纤维化，从而面临漏诊风险。 研究进一步揭示，问题在晚期纤维化患病率较高的人群中尤为突出。众所周知，T2DM患者是肝纤维化快速进展的高危群体，其晚期纤维化的患病率可能显著高于普通人群。该分析模拟显示，当患病率上升到30%至50%的范围内时，FIB-4的阴性预测值会急剧下降至0.70以下。这一数据强烈提示，在当前指南推荐的使用FIB-4作为初筛工具的策略下，大量本应被识别出来的高风险T2DM患者可能被错误地归类，从而错失早期干预和专科转诊的时机。 另一方面，当采用较高的FIB-4阈值（2.67至3.25）时，虽然确诊能力很强——特异性高达0.92，阳性预测值达到0.70，但其发现疾病的能力却非常有限，灵敏度低至0.33。这表明高阈值不适用于广泛的筛查目的，因为它会漏掉超过三分之二的晚期纤维化病例。 该荟萃分析共纳入了12项研究，涉及全球范围内5624名经肝脏活检确诊的T2DM合并MASLD患者，确保了结论的广泛代表性和可靠性。分析还指出，患者年龄、更晚期纤维化的比例等因素可能进一步影响FIB-4的准确性，强调了对这一人群需要更个体化的评估方法。 这些发现对广大初级保健医生、内分泌科医生及肝病科医生具有直接的实践意义。它警示临床工作者，对于T2DM患者，单纯依赖FIB-4指数可能不足以安全地排除严重的肝脏疾病。研究团队在文中强调，当前的临床管理路径可能需要调整，例如考虑对T2DM患者采用更低的FIB-4阈值来触发进一步检查，或者更频繁地进行FIB-4评估。 同时，研究支持了当前国际指南中已提及的补充策略的重要性，即在FIB-4初筛后，对于不确定或高危的患者，应积极采用第二线评估工具。这包括诸如振动控制瞬时弹性成像（VCTE）、血清学标志物如增强肝纤维化（ELF）检测，或在亚洲地区应用日益广泛的Mac-2结合蛋白糖基化异构体（M2BPGi）等。开发融合了T2DM特异性风险因素（如血糖控制情况）的新型纤维化评分系统，也被认为是未来的重要方向。 随着全球T2DM和MASLD患病率的持续攀升，如何在资源有限的情况下精准识别出肝病进展风险最高的个体，已成为公共卫生和临床医学面临的关键挑战。这项研究为优化这一高风险人群的肝纤维化筛查策略提供了关键的循证依据，呼吁学界和临床界共同审视并完善现有实践。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Hepatobiliary Surg Nutr | Volume 14, Issue 6 10.21037/hbsn-2025-439 05 Diabetology & metabolic syndrome IF: 03.900 代谢控制对2型糖尿病合并慢性多支冠状动脉疾病患者心血管结局的影响：一项队列研究 Andrade, Vitor Coutinho, Rezende, Paulo Cury, Hueb, Whady, Garcia, Rosa Maria Rahmi, de Assis, Arthur Cicupira Rodrigues, da Silva, Marcela Francisca, etc. 一项发表在Diabetology & metabolic syndrome上的研究，深入探讨了代谢控制水平对于2型糖尿病合并慢性多支冠状动脉疾病患者长期心血管健康的关键影响。该研究由Andrade, Vitor Coutinho、Rezende, Paulo Cury、Hueb, Whady等研究者共同完成。 研究团队回顾性分析了自1995年至2010年间纳入的884名患者数据，最终筛选出718名符合条件的研究对象进行深入分析。这些患者平均年龄为61岁，其中女性占比35.3%。研究的核心在于评估低密度脂蛋白胆固醇、糖化血红蛋白和甘油三酯这三项关键代谢指标的控制情况与心血管结局之间的关联。根据指标达标数量，患者被分为四个组别进行长期随访，平均随访时间长达8年。 分析结果显示，患者代谢控制情况分布如下：27.8%的患者三项指标均控制在目标范围内，36.2%的患者有两项达标，24.3%的患者仅一项达标，而11.7%的患者则三项指标均未达标。研究团队在调整了年龄、性别、吸烟状况、射血分数、病变血管数量及初始治疗方案等多种潜在混杂因素后，进行了严谨的统计分析。 研究发现了一个清晰的趋势：代谢指标控制得越差，主要不良心血管事件的发生风险就越高，呈现出显著的“剂量-反应”关系。具体而言，与三项指标全部达标的患者群体相比，那些没有任何一项指标达标的患者，在长期随访中遭遇全因死亡、心肌梗死、卒中或非计划性血运重建等复合终点的风险增加了近三倍，其风险比高达2.87。 这项研究通过长期的队列数据表明，对于已经确诊为稳定型冠状动脉疾病和2型糖尿病的患者而言，持续、综合地管理好血脂和血糖等代谢指标，对于降低未来发生严重心血管事件的风险具有明确的临床重要性。研究结果强调了在这一高危人群中实施全面风险管理策略的必要性。 本文由 天纳乾坤 编辑 扫描二维码查看源文 Diabetology & metabolic syndrome | Ahead of Print. 10.1186/s13098-025-02027-6 中国发表（133） China Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.01Dual clinical utility of cholesterol, high density lipoprotein, and glucose index: from advanced cardiovascular-kidney-metabolic syndrome pathogenesis to inflammatory-mediated mortality across early-transitional stages胆固醇-高密度脂蛋白-葡萄糖指数的双重临床效用：从晚期心血管-肾脏-代谢综合征发病机制到早期过渡阶段的炎症介导死亡率DOI: 10.1186/s13098-025-02055-2 npj science of food IF: 07.800Ahead of Print.No.02A moderate lard-included diet reduces fat deposition and inflammation in the adipose tissue适量摄入猪油饮食可减少脂肪组织中的脂肪沉积和炎症DOI: 10.1038/s41538-025-00657-8 Nature neuroscience IF: 20.000Ahead of Print.No.03Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus明亮光线经由与下丘脑外侧区相关的视觉环路抑制摄食并减缓体重增加DOI: 10.1038/s41593-025-02156-1 Scientific reports IF: 03.900Ahead of Print.No.04MiRNA expression analysis from circulating exosomes in Barrett's esophagus patients with visceral obesity内脏肥胖巴雷特食管患者循环外泌体中的MiRNA表达分析DOI: 10.1038/s41598-025-29379-3 BMJ open IF: 02.300Volume 15, Issue 12No.05Developing policy on sugar-sweetened beverages for children and adolescents in China: a qualitative study of stakeholder views and perceptions制定中国儿童及青少年含糖饮料政策的探索：一项关于利益相关者观点与认知的定性研究DOI: 10.1136/bmjopen-2025-098746 Phytomedicine IF: 08.300Ahead of Print.No.06Shenling Baizhu Powder attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice参苓白术散通过肠-脑轴改善饮食诱导肥胖小鼠的认知障碍DOI: 10.1016/j.phymed.2025.157654 Journal of applied toxicology IF: 02.800Ahead of Print.No.07Atypical Antipsychotics-Induced Glucose and Lipid Metabolism Disorders and Therapeutic Intervention非典型抗精神病药所致糖脂代谢紊乱及治疗干预DOI: 10.1002/jat.70036 International immunopharmacology IF: 04.700Ahead of Print.No.08GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathwayGLP-1受体激动剂利拉鲁肽通过GLP-1R-AMPK/SIRT1通路减轻肌腱细胞炎症和内质网应激促进肩袖愈合DOI: 10.1016/j.intimp.2025.116010 Eur J Med Res IF: 03.400Ahead of Print.No.09Combined triglyceride-glucose index and systemic inflammation response index are associated with coronary artery stenosis severity in acute coronary syndrome: a retrospective cohort study联合甘油三酯-葡萄糖指数与全身炎症反应指数与急性冠脉综合征冠脉狭窄严重程度相关：一项回顾性队列研究DOI: 10.1186/s40001-025-03650-9 Free radical biology & medicine IF: 08.200Ahead of Print.No.10Insulin-activated β-cell-liver axis protects against acetaminophen-induced acute liver injury by suppressing oxidative stress and purine catabolism胰岛素激活的β细胞-肝脏轴保护对乙酰氨基酚所致急性肝损伤的机制：抑制氧化应激与嘌呤分解代谢DOI: 10.1016/j.freeradbiomed.2025.12.009 Advanced science IF: 14.100Ahead of Print.No.11Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1(+) Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid结直肠癌细胞的武器：RNF32募集SPP1阳性巨噬细胞促进肝转移，吲哚-3-乙酸可靶向干预DOI: 10.1002/advs.202519735 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.12Bioinformatics and experimental validation of MAPK pathway activation in diabetic kidney disease induced by glucose variability血糖波动诱导的糖尿病肾病中MAPK通路激活的生物信息学与实验验证DOI: 10.1016/j.jgeb.2025.100598 Biochim Biophys Acta Mol Basis Dis IF: 04.200Ahead of Print.No.13Duration-dependent alterations of lipid profiles and microvascular complications in GCK-MODYGCK-MODY中脂质谱与微血管并发症的时长依赖性改变DOI: 10.1016/j.bbadis.2025.168137 Stem cell research & therapy IF: 07.300Ahead of Print.No.14‌Dual-target hUCMSCs/EVs therapy for autism spectrum disorder: remodeling gut microbiota and modulating neuroimmune crosstalk in a valproic acid-induced C57BL/6 mice model双靶向hUCMSCs/EVs疗法治疗自闭症谱系障碍：在丙戊酸诱导的C57BL/6小鼠模型中重塑肠道微生物群及调控神经免疫交互DOI: 10.1186/s13287-025-04829-x BMC urology IF: 01.900Ahead of Print.No.15Association between red cell distribution width-to-albumin ratio and risk of diabetic kidney disease: a cross-sectional NHANES study红细胞分布宽度与白蛋白比值与糖尿病肾病风险的相关性：一项基于NHANES的横断面研究DOI: 10.1186/s12894-025-02009-w Nature communications IF: 15.700Ahead of Print.No.16Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction常见疾病中循环蛋白质组的遗传图谱分析提示致病蛋白并提升风险预测效能DOI: 10.1038/s41467-025-67238-x Pediatric research IF: 03.100Ahead of Print.No.17Sleep heterogeneity in adolescents with type 1 diabetes: correlations with glycemic control, stigma, and resilience青少年1型糖尿病患者的睡眠异质性：与血糖控制、病耻感及心理韧性的相关性研究DOI: 10.1038/s41390-025-04644-3 Nature communications IF: 15.700Ahead of Print.No.18Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation高血糖通过CD11b乳酸化修饰损伤巨噬细胞胞葬作用加剧骨关节炎DOI: 10.1038/s41467-025-67473-2 Obesity reviews IF: 07.400Ahead of Print.No.19Circulating Proteins Link Obesity With Cardiac Remodeling: Insights From Mendelian Randomization循环蛋白连接肥胖与心脏重塑：孟德尔随机化研究的启示DOI: 10.1111/obr.70059 Nano letters IF: 09.100Ahead of Print.No.20Programming Molecular Switches within Capacitive PEDOT:DNA Hydrogels for Deciphering Pathophysiological Microenvironment Dynamics in Diabetic Wound在电容式PEDOT:DNA水凝胶中编程分子开关用于解码糖尿病伤口病理生理微环境动态DOI: 10.1021/acs.nanolett.5c05009 J Neurointerv Surg IF: 04.300Ahead of Print.No.21Safety and efficacy of sequential intra-arterial and intravenous administration of tirofiban during the periprocedural period of stenting in perforator-rich intracranial arteries穿支丰富颅内动脉支架围手术期序贯动脉内与静脉内应用替罗非班的安全性与有效性DOI: 10.1136/jnis-2025-024471 Int J Biol Macromol IF: 08.500Ahead of Print.No.22Adaptive injectable pullulan/carboxymethyl chitosan hydrogel accelerates diabetic wound healing through antibacterial, angiogenic, and immunomodulatory effects自适应可注射普鲁兰糖/羧甲基壳聚糖水凝胶通过抗菌、促血管生成和免疫调节作用加速糖尿病伤口愈合DOI: 10.1016/j.ijbiomac.2025.149616 European journal of pharmacology IF: 04.700Ahead of Print.No.23Metformin's Hidden Power: Unveiling Its Role in Melanoma Suppression Through endo-lysosome pH and Autophagy Regulation二甲双胍的隐藏力量：通过内溶酶体pH与自噬调控揭示其在黑色素瘤抑制中的作用DOI: 10.1016/j.ejphar.2025.178438 Fitoterapia IF: 02.600Ahead of Print.No.24Amide alkaloids from the fruits of Piper longum L. and their bioactivities长果胡椒果实中酰胺生物碱的分离鉴定及其生物活性研究DOI: 10.1016/j.fitote.2025.107024 Fitoterapia IF: 02.600Ahead of Print.No.25Integrating mouse oral trial, LC-HRMS-based untargeted metabolomics and network pharmacology for screening bioactive components of Astragalus membranaceus curing type-II diabetes mellitus (T2DM)整合小鼠口服试验、LC-HRMS非靶向代谢组学与网络药理学技术筛选黄芪治疗2型糖尿病的生物活性成分DOI: 10.1016/j.fitote.2025.107033 Arch Biochem Biophys IF: 03.000Ahead of Print.No.26LncRNA SNHG6 Attenuates Ferroptosis in High Glucose-treated Renal Tubular Epithelial Cells by Stabilizing YY1 to Activate the PI3K/AKT/GSK-3β PathwayLncRNA SNHG6通过稳定YY1激活PI3K/AKT/GSK-3β通路减轻高糖处理的肾小管上皮细胞铁死亡DOI: 10.1016/j.abb.2025.110702 Phytomedicine IF: 08.300Ahead of Print.No.27Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3藏花醛通过调节转录因子Forkhead Box O3抑制铁死亡从而加速糖尿病伤口愈合DOI: 10.1016/j.phymed.2025.157675 Phytomedicine IF: 08.300Ahead of Print.No.28Corylin ameliorates diabetic osteoporosis by inhibiting inflammation via targeting RAG1Corylin通过靶向RAG1抑制炎症改善糖尿病骨质疏松症DOI: 10.1016/j.phymed.2025.157671 Phytomedicine IF: 08.300Ahead of Print.No.29Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathySwietenine通过激活线粒体自噬减轻糖尿病肾病的肾小管损伤DOI: 10.1016/j.phymed.2025.157668 Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.30Chiglitazar, a PPAR pan-agonist: Impacts on type 2 diabetes mellitus and multi-system metabolic regulation - A reviewPPAR泛激动剂Chiglitazar：对2型糖尿病及多系统代谢调节的影响——一篇综述DOI: 10.1016/j.biopha.2025.118850 Cell reports IF: 06.900Ahead of Print.No.31Tracing the origin of testosterone-producing Leydig cells during pubertal development, homeostasis, and regeneration追踪睾酮生成Leydig细胞在青春期发育、稳态和再生过程中的起源DOI: 10.1016/j.celrep.2025.116674 J Diabetes Investig IF: 03.000Ahead of Print.No.32FGF11 regulated by CTBP1-AS2/miR-520a-5p/miR-432-5p axis inhibits the progression and angiogenesis in high glucose-treated human microvascular endothelial cellsCTBP1-AS2/miR-520a-5p/miR-432-5p轴调控的FGF11抑制高糖处理的人微血管内皮细胞的进展与血管生成DOI: 10.1111/jdi.13990 J Clin Monit Comput IF: 02.200Ahead of Print.No.33Predicting difficult videolaryngoscopic intubation in patients with obesity using ultrasound: an observational, prospective study使用超声预测肥胖患者视频喉镜下插管困难的观察性前瞻性研究DOI: 10.1007/s10877-025-01394-9 Am J Gastroenterol IF: 07.600Ahead of Print.No.34Long-term effectiveness of tenofovir alafenamide versus entecavir in treatment-naïve chronic hepatitis B: A REAL-B study替诺福韦艾拉酚胺对比恩替卡韦在初治慢性乙型肝炎患者中的长期有效性：一项REAL-B研究DOI: 10.14309/ajg.0000000000003881 Skin research and technology IF: 03.200Volume 31, Issue 12No.35Clinical Characteristics of Plantar Warts and Association With BMI: A Retrospective Case Series Study跖疣的临床特征及其与BMI的关联：一项回顾性病例系列研究DOI: 10.1111/srt.70303 Gut microbes IF: 11.000Volume 17, Issue 1No.36Helicobacter pylori infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m(6)A modification幽门螺杆菌感染通过乳酸化驱动的WTAP介导的m6A修饰加重肝脏脂肪变性DOI: 10.1080/19490976.2025.2599543 Gynecological endocrinology IF: 01.700Volume 41, Issue 1No.37A review of immunometabolic crosstalk in PCOS-related pregnancy loss: mechanisms and emerging therapeutic strategiesPCOS相关流产中免疫代谢串扰的综述：机制与新兴治疗策略DOI: 10.1080/09513590.2025.2600160 Int J Clin Oncol IF: 02.800Ahead of Print.No.38Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies子宫内膜癌筛查进展：现有方法与新兴技术的全面综述DOI: 10.1007/s10147-025-02941-9 Breast Cancer Res Treat IF: 03.000Volume 215, Issue 1No.39Risk factors for postoperative bleeding following breast cancer surgery: a systematic review and meta-analysis乳腺癌术后出血的风险因素：一项系统评价与荟萃分析DOI: 10.1007/s10549-025-07849-6 Molecular biology reports IF: 02.800Volume 53, Issue 1No.40Exploration of common therapeutic targets for diabetic nephropathy and diabetic foot ulcers by integrated bioinformatics analysis and experimental validation整合生物信息学分析与实验验证探索糖尿病肾病和糖尿病足溃疡的共同治疗靶点DOI: 10.1007/s11033-025-11350-0 Irish journal of medical science IF: 01.600Ahead of Print.No.41Vitamin D deficiency and depression in obese adults: NHANES 2009-2018维生素D缺乏与肥胖成人抑郁：基于NHANES 2009-2018数据的分析DOI: 10.1007/s11845-025-04224-8 Clin Appl Thromb Hemost IF: 02.000Volume 31, Issue No.42Effect of Physical Restraint on the Occurrence of Venous Thromboembolism in Stroke Patients身体约束对卒中患者静脉血栓栓塞发生的影响DOI: 10.1177/10760296251408064 The FASEB journal : IF: 04.200Volume 39, Issue 24No.43Bruceine A Ameliorates Osteoporosis Through Suppression of RACK1-Mediated OsteoclastogenesisBruceine A通过抑制RACK1介导的破骨细胞生成改善骨质疏松DOI: 10.1096/fj.202502953R JMIR serious games IF: 04.100Volume 13, Issue No.44Development and Evaluation of a Monocular Camera-Based Mobile Exergame for at-Home Intervention in Individuals at High Risk of Type 2 Diabetes: Randomized Controlled Trial开发与评估基于单目摄像头的移动体感游戏用于2型糖尿病高风险人群的家庭干预：一项随机对照试验DOI: 10.2196/75823 Journal of materials chemistry IF: 05.700Ahead of Print.No.45A multifunctional composite hydrogel with natural polymer silk fibroin and gelatin for promoting chronic wound healing一种用于促进慢性伤口愈合的含天然聚合物丝素蛋白和明胶的多功能复合水凝胶DOI: 10.1039/d5tb02034d Endocrine connections IF: 02.800Ahead of Print.No.46Real-world Pharmacovigilance Study of Drug-induced Diabetes Insipidus from the FAERS Database基于FAERS数据库的药物性尿崩症真实世界药物警戒研究DOI: 10.1530/EC-25-0734 Journal of global health IF: 04.300Volume 15, Issue No.47Longitudinal insights into comorbidity patterns and burden among middle-aged and older adults with diabetes in China: a nine-year cohort study using CHARLS中国中老年糖尿病患者合并症模式与负担的纵向洞察：一项基于CHARLS的九年队列研究DOI: 10.7189/jogh.15.04353 Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.48Hsa_circ_0015335 as a potential biomarker for cognitive decline in type 2 diabetes mellitusHsa_circ_0015335：一个潜在的2型糖尿病认知功能下降生物标志物DOI: 10.1177/13872877251405447 Drug delivery IF: 08.100Volume 32, Issue 1No.49Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis无针注射器与胰岛素笔在糖尿病管理中的有效性、安全性及以患者为中心的结局：一项全面荟萃分析DOI: 10.1080/10717544.2025.2597906 The Journal of headache and pain IF: 07.900Volume 26, Issue 1No.50L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validationL3MBTL2作为三叉神经痛的新治疗靶点：来自TWAS、多组织MR及实验验证的证据DOI: 10.1186/s10194-025-02218-6 Journal of pain research IF: 02.500Volume 18, Issue No.51Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy神经病理性疼痛与阿尔茨海默病之间的因果关系：一项结合多组学孟德尔随机化与糖尿病神经病变潜在保护作用的探索性证据研究DOI: 10.2147/JPR.S554433 Frontiers in public health IF: 03.400Volume 13, Issue No.52Multimorbidity patterns and cognitive frailty in adults aged over 50 years: China perspective中国50岁以上成年人的多重慢病模式与认知衰弱DOI: 10.3389/fpubh.2025.1701955 Future medicinal chemistry IF: 03.400Ahead of Print.No.53Small molecule inhibitors of HG-induced VEC ferroptosis: synthetic advances and therapeutic applications高血糖诱导的血管内皮细胞铁死亡的小分子抑制剂：合成进展与治疗应用DOI: 10.1080/17568919.2025.2602422 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.54Accurate screening of patients with diabetes based on physical examination: pancreas imaging features from chest CT and laboratory data基于体检的糖尿病患者精准筛查：胸部CT胰腺影像特征与实验室数据DOI: 10.3389/fendo.2025.1698247 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.55Prediction model for cognitive impairment in maintenance hemodialysis patients: the role of diabetes维持性血液透析患者认知功能损害的预测模型：糖尿病的作用DOI: 10.3389/fendo.2025.1594605 Risk Manag Healthc Policy IF: 02.000Volume 18, Issue No.56Analysis of Risk Factors of Postoperative Dry Eye in Cataract Patients Based on Lens Nucleus Hardness Grading基于晶状体核硬度分级的白内障患者术后干眼危险因素分析DOI: 10.2147/RMHP.S565376 Frontiers in immunology IF: 05.900Volume 16, Issue No.57Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment肿瘤相关Tn与STn抗原：从分子机制到精准诊疗DOI: 10.3389/fimmu.2025.1660852 Frontiers in nutrition IF: 05.100Volume 12, Issue No.58Comprehensive assessment of dietary micronutrient profiles and their effects on hemoglobin levels and anemia: provincial nutrition and health monitoring膳食微量营养素谱及其对血红蛋白水平与贫血影响的综合评估：省级营养与健康监测DOI: 10.3389/fnut.2025.1638705 Frontiers in nutrition IF: 05.100Volume 12, Issue No.59Association between geriatric nutritional risk index and fecal incontinence in individuals with stroke: mediating roles of systemic immune inflammation index and oxidative balance scores老年营养风险指数与卒中患者大便失禁的关联：系统免疫炎症指数和氧化平衡评分的中介作用DOI: 10.3389/fnut.2025.1692314 ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.60Mitochondrial-Targeting Drug-Loaded Nanoparticles Reprogram Macrophage Metabolism via ROS/NO Co-elimination for Diabetic Wound Healing线粒体靶向载药纳米颗粒通过ROS/NO共消除重编程巨噬细胞代谢促进糖尿病伤口愈合DOI: 10.1021/acsami.5c19664 ACS nano IF: 16.000Ahead of Print.No.61Anchoring Sn-Containing High-Entropy Alloy PtFeCoNiCuSn on SnO(2) for Improving Acetone Detection Ability将含锡高熵合金PtFeCoNiCuSn锚定在SnO2上以提升丙酮检测能力DOI: 10.1021/acsnano.5c15097 ACS sensors IF: 09.100Ahead of Print.No.62An Ant-Nest-Structured Wearable Sensor with pH Calibration for Reliable Monitoring of Sweat Glucose一种集成pH校准的蚁巢结构可穿戴传感器用于汗液葡萄糖可靠监测DOI: 10.1021/acssensors.5c03084 Zhong Nan Da Xue Xue Bao Yi Xue BanVolume 50, Issue 8No.63[Latent profile types and influencing factors of medication adherence mechanisms among rural older adults with multiple chronic conditions]农村多重慢病老年人用药依从性机制的潜在剖面类型及影响因素研究DOI: 10.11817/j.issn.1672-7347.2025.250141 Molecular Medicine Reports IF: 03.500Volume 33, Issue 2No.64Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)胰岛素受体底物/PI3K/Akt介导的胰岛素抵抗在糖尿病中的影响与治疗DOI: 10.3892/mmr.2025.13773 Biomedical reports IF: 01.900Volume 24, Issue 2No.65ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cellsERp46缓解脂毒性内质网应激以维持β细胞中GLUT2的表达和胰岛素分泌DOI: 10.3892/br.2025.2095 Ecology and evolution IF: 02.300Volume 15, Issue 12No.66Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches脑转录组学揭示高原鳅洞穴适应的分子机制DOI: 10.1002/ece3.72652 J Am Chem Soc IF: 15.600Ahead of Print.No.67Small-Molecule Fe(3+)-Based Magnetic Resonance Imaging Probe Enables Noninvasive Imaging of Pancreatic Zn(2+) and β-Cell Function In Vivo基于小分子Fe(3+)的磁共振成像探针实现胰腺Zn(2+)及β细胞功能的体内无创成像DOI: 10.1021/jacs.5c17216 FCVM IF: 02.900Volume 12, Issue No.68Combined effects of insulin resistance and altitude of residence on 10-year risk of atherosclerotic cardiovascular disease胰岛素抵抗与居住海拔对动脉粥样硬化性心血管疾病10年风险的联合影响DOI: 10.3389/fcvm.2025.1656537 Food science & nutrition IF: 03.800Volume 13, Issue 12No.69Takeaway Food Consumption, Dietary Inflammatory Index, and Cardiometabolic Risk Factors in US Adults: Findings From NHANES (2009-2018)美国成年人外卖食品摄入、膳食炎症指数与心脏代谢风险因素：来自NHANES (2009-2018)的发现DOI: 10.1002/fsn3.71316 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.70Comparative analysis of the therapeutic effect of antibiotic bone cement on Wagner grade 3 or 4 diabetic foot ulcer in heel and non-heel areas: a retrospective cohort study抗生素骨水泥治疗足跟与非足跟区Wagner 3或4级糖尿病足溃疡的疗效比较：一项回顾性队列研究DOI: 10.3389/fendo.2025.1662731 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.71Transcriptomic profiling of diabetic retinopathy: insights into RPL11 and bisphenol A糖尿病视网膜病变的转录组学分析：聚焦RPL11与双酚ADOI: 10.3389/fendo.2025.1705233 Int J Nanomedicine IF: 06.500Volume 20, Issue No.72Mesenchymal Stem Cell-Derived Exosomes for Ocular Diseases: Therapeutic Mechanisms and Clinical Perspectives间充质干细胞来源的外泌体在眼部疾病中的应用：治疗机制与临床前景DOI: 10.2147/IJN.S555771 Exp Ther Med IF: 02.300Volume 31, Issue 2No.73Outcomes of anti-VEGF therapy compared with conventional interventions in diabetic retinopathy management抗血管内皮生长因子疗法与传统干预在糖尿病视网膜病变管理中的疗效对比DOI: 10.3892/etm.2025.13028 Organic letters IF: 05.000Ahead of Print.No.74NiCl(2)/Hdipm-Catalyzed 2-OH-Selective Alkylation of Glycoside trans-DiolsNiCl₂/Hdipm催化的糖苷反式二醇2-OH选择性烷基化DOI: 10.1021/acs.orglett.5c04886 Exp Ther Med IF: 02.300Volume 31, Issue 2No.75The influence of fetal sex on preterm birth risk in gestational diabetes mellitus: A retrospective cohort study胎儿性别对妊娠期糖尿病孕妇早产风险的影响：一项回顾性队列研究DOI: 10.3892/etm.2025.13034 NeuroprotectionVolume 3, Issue 1No.76Advancing neuroprotection and atherosclerosis prevention through familial hypercholesterolemia management: Analyzing comorbidity burden with stroke, coronary heart disease, hypertension, and diabetes通过管理家族性高胆固醇血症推动神经保护与动脉粥样硬化预防：分析其与卒中、冠心病、高血压和糖尿病的合并症负担DOI: 10.1002/nep3.72 Frontiers in physiology IF: 03.400Volume 16, Issue No.77Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis不同水平的体重指数与胃食管反流病风险之间的关联：一项采用剂量反应Meta分析的系统评价DOI: 10.3389/fphys.2025.1675457 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.78Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats二甲双胍联合利拉鲁肽治疗PCOS：在女性中的临床有效性及其通过调节肠道微生物组获得的临床前洞见DOI: 10.3389/fendo.2025.1599879 Hepatobiliary Surg Nutr IF: 07.800Volume 14, Issue 6No.79From NAFPD to MAFPD: a literature review of implications of a nomenclature change从NAFPD到MAFPD：命名变更影响的文献综述DOI: 10.21037/hbsn-24-284 Frontiers in nutrition IF: 05.100Volume 12, Issue No.80Dietary patterns and obesity are associated with type 2 diabetes risk in elderly Chinese men: a machine learning approach饮食模式与肥胖和中国老年男性2型糖尿病风险相关：一项机器学习方法研究DOI: 10.3389/fnut.2025.1705683 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.81Association between vascular aging and cardiovascular-kidney-metabolic syndrome血管老化与心血管-肾脏-代谢综合征（CKM）的关联DOI: 10.3389/fendo.2025.1665836 Experimental Eye Research IF: 02.700Ahead of Print.No.82Canagliflozin inhibits NLRP3 Inflammasome activation to protect the Retinal Neurovascular Unit in a Mouse Retinal Vein Occlusion Model卡格列净通过抑制NLRP3炎症小体活化保护小鼠视网膜静脉阻塞模型中的视网膜神经血管单元DOI: 10.1016/j.exer.2025.110803 BMC geriatrics IF: 03.800Ahead of Print.No.83eHealth literacy mediates self-advocacy and self-management in older adults with diabetes电子健康素养在老年糖尿病患者自我倡导与自我管理中的中介作用DOI: 10.1186/s12877-025-06859-9 Hereditas : IF: 02.500Ahead of Print.No.84CD248, targeted by veratramine and neobavaisoflavone, mediates pathological changes of renal tubular epithelial cells induced by high glucoseCD248介导高糖诱导的肾小管上皮细胞病理变化，是黎芦胺和新巴伐异黄酮的作用靶点DOI: 10.1186/s41065-025-00624-z Stem cell research & therapy IF: 07.300Ahead of Print.No.85Mesenchymal stem cell-derived extracellular vesicles for disease therapy by regulating ferroptosis: focus on diabetes mellitus and diabetic complications靶向铁死亡：间充质干细胞来源的细胞外囊泡的疾病治疗潜力——聚焦糖尿病及其并发症DOI: 10.1186/s13287-025-04852-y Eur J Med Res IF: 03.400Ahead of Print.No.86Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis经皮椎体后凸成形术后骨水泥渗漏的相关风险因素：一项回顾性分析DOI: 10.1186/s40001-025-03608-x Eur J Med Res IF: 03.400Ahead of Print.No.87A predictive nomogram for hemorrhage risk following endoscopic submucosal dissection of gastrointestinal tumors: a retrospective cohort study预测胃肠道肿瘤内镜黏膜下剥离术后出血风险的列线图模型：一项回顾性队列研究DOI: 10.1186/s40001-025-03599-9 Genome medicine IF: 11.200Ahead of Print.No.88Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy全转录组关联研究揭示肾活检确诊的糖尿病肾病新型致病基因DOI: 10.1186/s13073-025-01590-x BMC ophthalmology IF: 01.700Ahead of Print.No.89Effects of blood pressure and blood glucose levels on foveal avascular zone area血压与血糖水平对黄斑无血管区面积的影响DOI: 10.1186/s12886-025-04534-6 BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.90Independent risk factors of hypertension in patients with chronic heart failure: insights from univariate and multivariate analyses慢性心力衰竭患者高血压的独立危险因素：基于单因素与多因素分析的启示DOI: 10.1186/s12872-025-05408-x Scientific reports IF: 03.900Ahead of Print.No.91Long-term real-world performance of the Bayer Contour TS point-of-care testing glucose meters拜安捷血糖仪长期真实世界性能评估DOI: 10.1038/s41598-025-30850-4 Nature communications IF: 15.700Volume 16, Issue 1No.92Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases人工智能驱动的视网膜神经纤维层代谢组学解析死亡与心脏代谢疾病风险DOI: 10.1038/s41467-025-66979-z Food chemistry IF: 09.800Ahead of Print.No.93Synergistic effects of endogenous protein components and starch molecular structure on physicochemical, rheological and digestive properties in rice内源性蛋白组分与淀粉分子结构的协同作用对水稻理化、流变及消化特性的影响DOI: 10.1016/j.foodchem.2025.147443 Phytomedicine IF: 08.300Ahead of Print.No.94Multi-level intervention of Tangluoning on mitochondrial thioredoxin deficiency in Schwann cells ameliorates diabetic peripheral neuropathy汤剂Tangluoning对雪旺细胞线粒体硫氧还蛋白缺乏的多层次干预改善糖尿病周围神经病变DOI: 10.1016/j.phymed.2025.157656 Biochemical pharmacology IF: 05.600Ahead of Print.No.95RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathwaysRIPK3缺乏通过抑制炎症信号和细胞应激通路调节蛋白质稳态改善糖尿病肌肉减少症DOI: 10.1016/j.bcp.2025.117627 BMC endocrine disorders IF: 03.300Ahead of Print.No.96Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes预测非ICU糖尿病患者低血糖：逻辑回归与人工神经网络模型的比较DOI: 10.1186/s12902-025-02125-6 Diabetologia IF: 10.200Ahead of Print.No.97LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogrammingLDHA通过代谢与表观遗传重编程诱导糖尿病中的β细胞去分化DOI: 10.1007/s00125-025-06626-w Molecular & cellular proteomics IF: 05.500Ahead of Print.No.98Plasma Proteomic Characterization of Adolescent Idiopathic Scoliosis青少年特发性脊柱侧凸的血浆蛋白质组特征DOI: 10.1016/j.mcpro.2025.101486 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.99Engineered MSCs secreting GLP-1 enhance β-cell survival and improve glycemic control in diabetic mice分泌GLP-1的工程化间充质干细胞增强β细胞存活并改善糖尿病小鼠血糖控制DOI: 10.1016/j.bbrc.2025.153105 Scientific reports IF: 03.900Volume 15, Issue 1No.100Information quality assessment and user engagement prediction of short videos about diabetic kidney disease on TikTok and bilibili抖音与哔哩哔哩平台上糖尿病肾病相关短视频的信息质量评估与用户参与度预测DOI: 10.1038/s41598-025-27650-1 Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.101Impact of metformin on intervertebral disc degeneration in patients with diabetes: a prospective cohort study from the UK biobank二甲双胍对糖尿病患者椎间盘退变的影响：一项基于英国生物样本库的前瞻性队列研究DOI: 10.1186/s13098-025-02050-7 Int J Biol Macromol IF: 08.500Ahead of Print.No.102Injectable adhesive self-healing hyaluronic acid-based hydrogel with microenvironment-responsive metformin delivery and photothermal antibacterial activity for diabetic infected wound healing用于糖尿病感染伤口愈合的可注射粘附自愈透明质酸基水凝胶：具有微环境响应性二甲双胍递送和光热抗菌活性DOI: 10.1016/j.ijbiomac.2025.149560 Biosensors & bioelectronics IF: 10.500Ahead of Print.No.103A skin-interfaced sensor for noninvasive monitoring of pharmacokinetic and pharmacodynamic responses用于无创监测药代动力学和药效学反应的皮肤接口传感器DOI: 10.1016/j.bios.2025.118301 Scientific reports IF: 03.900Volume 15, Issue 1No.104The role and potential mechanism of PEST-containing nuclear protein (PCNP) in endothelial cell angiogenesis in vitroPEST结构域核蛋白（PCNP）在体外内皮细胞血管生成中的作用和潜在机制DOI: 10.1038/s41598-025-27494-9 Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.105Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy预测增生性糖尿病视网膜病变患者玻璃体切除联合眼内注药术后玻璃体腔出血风险的模型DOI: 10.1016/j.pdpdt.2025.105313 Experimental Eye Research IF: 02.700Ahead of Print.No.106Autophagy and Mitophagy in Diabetic Retinopathy: The Effects and Mechanism of Action on the Neurovascular Unit自噬与线粒体自噬在糖尿病视网膜病变中的作用：对视神经血管单元的影响与机制DOI: 10.1016/j.exer.2025.110802 Biochemical pharmacology IF: 05.600Ahead of Print.No.107GLP-1 receptor agonists as a strategy to target ER stress in diabetic retinopathy以GLP-1受体激动剂为策略靶向内质网应激治疗糖尿病视网膜病变DOI: 10.1016/j.bcp.2025.117623 J Int Med Res IF: 01.500Volume 53, Issue 12No.108Noninvasive assessment of metabolic syndrome-related renal injury using magnetic resonance imaging fat fraction and apparent diffusion coefficient: A cross-sectional study应用磁共振成像脂肪分数与表观扩散系数无创评估代谢综合征相关肾损伤：一项横断面研究DOI: 10.1177/03000605251399039 Nature communications IF: 15.700Volume 16, Issue 1No.109Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus基于唾液、血清和尿液代谢组学的妊娠期糖尿病发病机制、诊断与预后研究DOI: 10.1038/s41467-025-65992-6 Brain & development IF: 01.300Ahead of Print.No.110Construction and clinical validation of a fetal brain magnetic resonance imaging-prediction model based on multimodal AI fusion algorithm基于多模态AI融合算法的胎儿脑磁共振成像预测模型的构建与临床验证DOI: 10.1016/j.braindev.2025.104492 Diabetologia IF: 10.200Ahead of Print.No.111Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in miceFXR表达下降协调新生小鼠β细胞质量发育与微生物胆汁酸代谢成熟DOI: 10.1007/s00125-025-06618-w Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.112Sex differences in metabolic syndrome among U.S. adolescents, NHANES 1999-2020美国青少年代谢综合征的性别差异：NHANES 1999-2020DOI: 10.1186/s13098-025-02052-5 BMC public health IF: 03.600Ahead of Print.No.113Outdoor food advertising landscape along school-age children's daily commute routes in Chengdu: implications for childhood obesity prevention成都学龄儿童日常通勤路线上的户外食品广告景观：对儿童肥胖预防的启示DOI: 10.1186/s12889-025-25806-2 BMC geriatrics IF: 03.800Ahead of Print.No.114Development of a sarcopenic obesity risk prediction model for older adults based on the CHARLS database基于CHARLS数据库的老年人肌肉减少性肥胖风险预测模型构建DOI: 10.1186/s12877-025-06688-w BMC gastroenterology IF: 02.600Ahead of Print.No.115The causal relationship between body mass index and perianal abscess: a Mendelian randomization study体重指数与肛周脓肿的因果关系：一项孟德尔随机化研究DOI: 10.1186/s12876-025-04555-x Clin Mol Hepatol IF: 16.900Ahead of Print.No.116Normal-weight MASLD: reclassification, characteristics, and adverse liver outcomes across diverse populations正常体重MASLD：不同人群中的重新分类、特征与不良肝脏结局DOI: 10.3350/cmh.2025.0851 Scientific reports IF: 03.900Ahead of Print.No.117Effects of excess bodyweight and flexible Flatfoot on female stance-phase lower-limb biomechanics assessed by statistical non-parametric mapping超重与柔性扁平足对女性站立期下肢生物力学的影响：基于统计非参数映射的评估DOI: 10.1038/s41598-025-32023-9 Nature communications IF: 15.700Volume 16, Issue 1No.118Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria肠道噬菌体生物库：靶向人体共生细菌的噬菌体集合DOI: 10.1038/s41467-025-61946-0 Adipocyte IF: 03.100Volume 14, Issue 1No.119CAPG enhances adipogenesis and inflammatory cytokine expression in adipocytesCAPG促进脂肪细胞分化并增强炎症细胞因子表达DOI: 10.1080/21623945.2025.2549456 The American surgeon IF: 00.900Ahead of Print.No.120Role of Bariatric Surgery in Modulating Fetuin-A and Metabolic Outcomes: A Systematic Review and Meta-Analysis减重手术在调节Fetuin-A及代谢结局中的作用：一项系统综述和荟萃分析DOI: 10.1177/00031348251407347 Biochim Biophys Acta Mol Cell Biol Lipids IF: 03.300Ahead of Print.No.121MiR-424-3p suppresses adipogenesis via HNRNPA0 targeting and p53-mediated ferroptosisMiR-424-3p通过靶向HNRNPA0和p53介导的铁死亡抑制脂肪生成DOI: 10.1016/j.bbalip.2025.159712 Fitoterapia IF: 02.600Ahead of Print.No.122Pharmacological insights on multifaceted therapeutic applications of stilbenoids: A comprehensive updates二苯乙烯类化合物多面治疗应用的药理学见解：全面更新DOI: 10.1016/j.fitote.2025.107034 Cancer letters IF: 10.100Ahead of Print.No.123High-fat diet induced ECM remodeling attenuates chemosensitivity in prostate cancer via activating Piezo1-dependent mitochondria-ER contacts高脂饮食诱导细胞外基质重塑通过激活Piezo1依赖性线粒体-内质网接触减弱前列腺癌化疗敏感性DOI: 10.1016/j.canlet.2025.218204 European journal of pharmacology IF: 04.700Ahead of Print.No.124GLP-1RA partially alleviates obesity-induced reproductive dysfunction driven by the interplay mechanisms of inflammation and metabolic dysregulation via the SIRT-associated pathwayGLP-1受体激动剂通过SIRT关联通路部分缓解由炎症与代谢失调相互作用驱动的肥胖所致生殖功能障碍DOI: 10.1016/j.ejphar.2025.178459 Brain research IF: 02.600Ahead of Print.No.125Unforgettable food memories in overweight/obese individuals-Evidence from Think/No-Think experiment超重/肥胖个体中难以忘记的食物记忆——来自想/不想范式实验的证据DOI: 10.1016/j.brainres.2025.150108 Cell metabolism IF: 30.900Ahead of Print.No.126Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade免疫检查点阻断下巨噬细胞PD-1调控能量消耗与代谢功能障碍DOI: 10.1016/j.cmet.2025.11.009 J Nutr Health Aging IF: 04.000Ahead of Print.No.127Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals膳食锰、2型糖尿病与心血管疾病：一项基于英国生物样本库的队列研究及针对超过27万人的荟萃分析DOI: 10.1016/j.jnha.2025.100754 Scientific reports IF: 03.900Ahead of Print.No.128The association of multiple metabolic disorders with the severity of fasting blood glucose and hepatic steatosis in a Chinese population with MAFLD: a cross-sectional study of over 3000 participants多项代谢紊乱与MAFLD中国人群空腹血糖水平和肝脂肪变严重程度的关联：一项超过3000人的横断面研究DOI: 10.1038/s41598-025-31652-4 Scientific reports IF: 03.900Volume 15, Issue 1No.129Activated vitamin D(3) improves the microbiota and intestinal barrier in type 2 diabetic mice via modulating AMPK activation活性维生素D3通过调控AMPK激活改善2型糖尿病小鼠的肠道菌群及屏障功能DOI: 10.1038/s41598-025-27937-3 Scientific reports IF: 03.900Volume 15, Issue 1No.130Diabetes duration, glycemic control, and risk of stroke and stroke subtypes: a nationwide prospective cohort study糖尿病病程、血糖控制与卒中及卒中亚型风险：一项全国性前瞻性队列研究DOI: 10.1038/s41598-025-27547-z Nature communications IF: 15.700Ahead of Print.No.131Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathwaySchisantherin A通过与肠道细菌相互作用经TGR5‒p-CREB‒STAT6信号通路刺激肥胖小鼠脂肪组织产热DOI: 10.1038/s41467-025-67172-y Scientific reports IF: 03.900Ahead of Print.No.132Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathwayCir醚醇通过PPAR-α/AMPK通路抑制氧化应激和改善能量代谢缓解糖尿病心肌病DOI: 10.1038/s41598-025-32157-w Int J Biol Macromol IF: 08.500Ahead of Print.No.133Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization靶向醛糖还原酶治疗肺纤维化：阻断脂肪酸从头合成可抑制促纤维化的M2型巨噬细胞极化DOI: 10.1016/j.ijbiomac.2025.149590 其他发布内容（287） More Published Articles European journal of pharmacology IF: 04.700Ahead of Print.No.01Dual Inhibition Strategy in Managing Neuronal Autophagy in PTZ-Induced Kindling in Mice: A Pharmacological Perspective on P2Y12 and SGLT2 Inhibitors双重抑制策略管理PTZ诱导的小鼠点燃模型中神经元自噬：P2Y12和SGLT2抑制剂的药理学视角DOI: 10.1016/j.ejphar.2025.178437 Food chemistry IF: 09.800Volume 498, Issue Pt 2No.02Germination time shapes digestibility, functionality, and structure of lupin-corn extrudates发芽时间影响羽扇豆-玉米挤压膨化食品的消化率、功能性和结构DOI: 10.1016/j.foodchem.2025.147245 Food chemistry IF: 09.800Volume 498, Issue Pt 2No.03Green and roasted coffee as novel substrates for kombucha fermentation: Modulation of bioactivity and phenolic profile绿原咖啡与烘焙咖啡作为康普茶发酵的新型基质：生物活性与酚类物质的调控DOI: 10.1016/j.foodchem.2025.147162 Digestive and Liver Disease IF: 03.800Ahead of Print.No.04Empagliflozin might improve chronic inflammatory bowel diseases also in humans恩格列净或可改善人类慢性炎症性肠病DOI: 10.1016/j.dld.2025.11.019 Scientific reports IF: 03.900Volume 15, Issue 1No.05Sleep quality in Spanish adults: an age- and sex-stratified cross-sectional study西班牙成年人睡眠质量：一项按年龄和性别分层的横断面研究DOI: 10.1038/s41598-025-27418-7 BMC health services research IF: 03.000Ahead of Print.No.06Perceptions of obesity among healthcare professionals in Malaysia: a subgroup analysis of the OPEN Models of Care survey马来西亚医疗专业人员对肥胖的认知：OPEN医疗模式调查的子组分析DOI: 10.1186/s12913-025-13867-3 J Cell Mol Med IF: 04.200Volume 29, Issue 23No.07Impact of High-Fat Diet on Biochemical Changes Following Experimental Myocardial Infarction高脂饮食对实验性心肌梗死后生化变化的影响DOI: 10.1111/jcmm.70984 International journal of cancer IF: 04.700Ahead of Print.No.08Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells运动后的血清能促进结肠癌细胞的DNA损伤修复并重塑其基因表达DOI: 10.1002/ijc.70271 Nutrition research IF: 03.100Ahead of Print.No.09Erratum to "Type 2-resistant starch and Lactiplantibacillus plantarum NCIMB 8826 result in additive and interactive effects in diet-induced obese mice" [Nutrition Research Volume 118, October 2023, Pages 12-28]勘误：《Type 2-resistant starch 与 Lactiplantibacillus plantarum NCIMB 8826 在饮食诱导肥胖小鼠中产生叠加和交互效应》[Nutrition Research Volume 118, October 2023, Pages 12-28]DOI: 10.1016/j.nutres.2025.11.006 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.10Within-family analysis of PRS(313): insights into breast cancer risk predictionPRS(313)的家族内分析：对乳腺癌风险预测的启示DOI: 10.1016/j.jgeb.2025.100605 Respiratory care IF: 02.100Ahead of Print.No.11Obesity Modifies the Effect of PEEP During Spontaneous Breathing in Acute Hypoxemic Respiratory Failure肥胖影响急性低氧性呼吸衰竭自主呼吸期间PEEP的效果DOI: 10.1177/19433654251399184 The Laryngoscope IF: 02.000Ahead of Print.No.12The Impact of Neck Circumference and BMI on Upper Airway Collapsibility and Risk of CCC in OSA颈围与BMI对OSA患者上气道塌陷性及CCC风险的影响DOI: 10.1002/lary.70301 Molecular metabolism IF: 06.600Ahead of Print.No.13Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance跨物种研究揭示黑皮质素3受体在青春期发育调控中的作用强于能量平衡调控DOI: 10.1016/j.molmet.2025.102301 Experimental gerontology IF: 04.300Ahead of Print.No.14Sarcopenia, Obesity, and Functional Decline: Converging Mechanisms and Emerging Diagnostic Frontiers肌少症、肥胖与功能衰退：机制交汇与新兴诊断前沿DOI: 10.1016/j.exger.2025.112993 Preventive medicine IF: 03.200Ahead of Print.No.15Nutritional awareness, dietary choices, and weight status营养认知、饮食选择与体重状况DOI: 10.1016/j.ypmed.2025.108486 Int J Sports Med IF: 02.200Ahead of Print.No.16Muscle-to-Bone Ratio in Collegiate Female Athletes in Low and High Impact Sports大学女运动员在低冲击与高冲击运动中的肌肉-骨骼比例DOI: 10.1055/a-2731-3735 Cell metabolism IF: 30.900Ahead of Print.No.17Bile acids regulate lipid metabolism through selective actions on fatty acid absorption胆汁酸通过选择性作用于脂肪酸吸收来调控脂质代谢DOI: 10.1016/j.cmet.2025.11.010 Epilepsy & behavior IF: 02.300Ahead of Print.No.18Transfer of Finnish adolescents with epilepsy to adult care: a population-based study芬兰青少年癫痫患者向成人护理的转移：一项基于人群的研究DOI: 10.1016/j.yebeh.2025.110856 Nutrition IF: 03.000Ahead of Print.No.19Combination of a modified dietary tool and spot urine collection: an improved method for daily sodium intake estimation结合改良的膳食评估工具与点尿样本：一种改进的每日钠摄入量估算方法DOI: 10.1016/j.nut.2025.113014 Journal of clinical neuroscience IF: 01.800Ahead of Print.No.20Obesity does not significantly impact clinical outcomes following anterior cervical discectomy and fusion肥胖对前路颈椎间盘切除融合术后的临床结局无显著影响DOI: 10.1016/j.jocn.2025.111807 Eur J Pharm Sci IF: 04.700Ahead of Print.No.21Elucidating the roles of TM7SF3 and LHFPL6 in the putative H(+)/OC antiporter function in the human brain capillary endothelial cell line, hCMEC/D3阐明TM7SF3和LHFPL6在人脑毛细血管内皮细胞系hCMEC/D3中推定的H(+)/OC反向转运体功能中的作用DOI: 10.1016/j.ejps.2025.107409 Seminars in neurology IF: 02.000Ahead of Print.No.22Orthostatic Tremor直立性震颤DOI: 10.1055/a-2762-9483 BMJ case reports IF: 00.500Volume 18, Issue 12No.23Thyrotoxic periodic paralysis: diagnostic and management considerations甲状腺毒性周期性麻痹：诊断与管理考量DOI: 10.1136/bcr-2025-269416 Nature communications IF: 15.700Volume 16, Issue 1No.24Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy功能分化的秀丽隐杆线虫BiP同源物调控机体生长、繁殖、应激抵抗、衰老与自噬DOI: 10.1038/s41467-025-65998-0 Journal fran?ais d'ophtalmologie IF: 01.100Ahead of Print.No.25Insulin eye drops as an effective alternative in persistent nodular episcleritis胰岛素滴眼液作为持续性结节性表层巩膜炎的有效替代疗法DOI: 10.1016/j.jfo.2025.104721 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.26Design biology and mind-body health设计生物学与心身健康DOI: 10.1016/j.jgeb.2025.100621 Brain research IF: 02.600Ahead of Print.No.27Serum phosphorylated IRS-1 at Ser(307) as a potential biomarker of stress-induced depressive-like behavior in rats血清磷酸化IRS-1（Ser307）作为应激诱导大鼠抑郁样行为的潜在生物标志物DOI: 10.1016/j.brainres.2025.150110 Molecular metabolism IF: 06.600Ahead of Print.No.28Beta-Cell-Specific C3 Deficiency Exacerbates Metabolic Dysregulation and Insulin Resistance in Obesityβ细胞特异性C3缺乏加剧肥胖中的代谢失调和胰岛素抵抗DOI: 10.1016/j.molmet.2025.102302 Prostaglandins Other Lipid Mediat IF: 02.500Ahead of Print.No.29Revealing the Biochemical Regulations of L-PGDS in Hepatic Insulin-Resistance using HepG2 cells利用HepG2细胞揭示L-PGDS在肝胰岛素抵抗中的生化调控机制DOI: 10.1016/j.prostaglandins.2025.107052 Eur J Pharm Sci IF: 04.700Ahead of Print.No.30Single-Dose Pharmacokinetics of Sublingual Semaglutide in Rats大鼠舌下给予司美格鲁肽的单剂量药代动力学研究DOI: 10.1016/j.ejps.2025.107406 Nutrition IF: 03.000Ahead of Print.No.31The impact of nutrition, exercise, and pharmacotherapy on menstrual health in adolescents with overweight and obesity营养、运动与药物治疗对青少年超重与肥胖人群月经健康的影响DOI: 10.1016/j.nut.2025.113021 Pharmacological research IF: 10.500Ahead of Print.No.32VEGF-B: A multifaceted modulator with emerging therapeutic applicationsVEGF-B：一种具有新兴治疗应用前景的多功能调节因子DOI: 10.1016/j.phrs.2025.108064 Scientific reports IF: 03.900Ahead of Print.No.33Comparative analysis of novel preprocessing techniques and deep learning based multi modal feature fusion for diabetic retinopathy grading用于糖尿病视网膜病变分级的创新预处理技术与基于深度学习的多模态特征融合的比较分析DOI: 10.1038/s41598-025-31339-w Artificial organs IF: 02.300Ahead of Print.No.34The Impact of Obesity on Durable Left Ventricular Assist Device Implantation: A Systematic Review and Meta-Analysis肥胖对长期左心室辅助装置植入的影响：一项系统综述与荟萃分析DOI: 10.1111/aor.70071 Scientific reports IF: 03.900Ahead of Print.No.35Ustekinumab may have therapeutic effects on autoimmune thyroid disease乌司奴单抗可能对自身免疫性甲状腺疾病具有治疗作用DOI: 10.1038/s41598-025-31266-w J Diabetes Investig IF: 03.000Ahead of Print.No.36Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large-scale diabetes registry J-DREAMS日本糖尿病患者eGFR持续下降的危险因素：基于大规模糖尿病登记库J-DREAMS的分析DOI: 10.1111/jdi.70214 Scientific reports IF: 03.900Volume 15, Issue 1No.37Nationwide study of income-based disparities in diabetic limb preservation in South Korea韩国糖尿病肢体保留收入差异的全国性研究DOI: 10.1038/s41598-025-27511-x Pilot and feasibility studies IF: 01.600Ahead of Print.No.38Feasibility of a prospective multicenter observational study-is diabetes a risk factor in ERAS joint arthroplasty?前瞻性多中心观察性研究的可行性——糖尿病是ERAS关节置换术的风险因素吗？DOI: 10.1186/s40814-025-01747-w Systematic reviews IF: 03.900Ahead of Print.No.39Prevalence and risk factors of work-related musculoskeletal disorders among Radiographers: a proposed systematic review and meta-analysis protocol放射技师工作相关肌肉骨骼疾病的患病率与危险因素：一项拟开展的系统评价与荟萃分析方案DOI: 10.1186/s13643-025-03017-5 Diabetology & metabolic syndrome IF: 03.900Volume 17, Issue 1No.40Assessing the impact of bariatric surgery on cardiovascular risk in type 2 diabetes: a systematic review and meta-analysis using OMICs data基于OMICs数据评估减重手术对2型糖尿病患者心血管风险的影响：一项系统回顾与Meta分析DOI: 10.1186/s13098-025-02002-1 BMC endocrine disorders IF: 03.300Ahead of Print.No.41Nationwide implementation of a diabetes self-management and network system improves outcomes in type 1 diabetes: real-world evidence from Thailand泰国全国范围内实施的糖尿病自我管理与网络系统改善1型糖尿病结局：真实世界证据DOI: 10.1186/s12902-025-02123-8 BMC public health IF: 03.600Ahead of Print.No.42Trends, challenges, and outcomes of extrapulmonary tuberculosis: a ten-year study in Cologne (2012-2022)肺外结核的流行病学趋势、诊治挑战与临床结局：一项德国科隆的十年研究（2012-2022年）DOI: 10.1186/s12889-025-25835-x BMC public health IF: 03.600Volume 25, Issue 1No.43Where low-income seniors receive their heart health and diabetes information: a cross-sectional survey低收入老年人心脏健康与糖尿病信息的来源：一项横断面调查DOI: 10.1186/s12889-025-25469-z Scientific reports IF: 03.900Ahead of Print.No.44Synthesis and antidiabetic evaluation of novel Tetrahydroacridine derivatives with computational insights新型四氢吖啶衍生物的合成、抗糖尿病评价与计算研究DOI: 10.1038/s41598-025-28702-2 Scientific reports IF: 03.900Ahead of Print.No.45Serum prolactin level in male type 2 diabetes mellitus patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2024埃塞俄比亚西北部贡达尔大学综合专科医院男性2型糖尿病患者血清催乳素水平研究，2024年DOI: 10.1038/s41598-025-32477-x Scientific reports IF: 03.900Volume 15, Issue 1No.46Greater exposure to PM(2.5) and PM(10) is associated with a higher BAD score: the Maastricht study较高浓度的PM2.5和PM10暴露与BAD评分升高相关：一项来自The Maastricht Study的研究DOI: 10.1038/s41598-025-27471-2 Scientific reports IF: 03.900Volume 15, Issue 1No.47Effect of posture on photoplethysmography signals from the posterior tibial artery in adults with and without type 2 diabetes体位对有无2型糖尿病的成年患者胫后动脉光电体积描记信号的影响DOI: 10.1038/s41598-025-28223-y Scientific reports IF: 03.900Ahead of Print.No.48Multidimensional assessment of large language model responses to patient questions on gestational diabetes mellitus大语言模型对妊娠期糖尿病患者问题的多维度评估DOI: 10.1038/s41598-025-27235-y The FEBS journal IF: 04.200Ahead of Print.No.49Comparative analysis of metabolic and functional cardiac alterations in diet- and genetically induced mouse models of cardiac dysfunction饮食与遗传诱导的心脏功能障碍小鼠模型中代谢与功能心脏改变的比较分析DOI: 10.1111/febs.70362 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.50Efficacy and safety of novel lipoprotein(a)-targeted therapies: A systematic review and meta-analysis of randomised controlled trials新型脂蛋白(a)靶向治疗的有效性与安全性：随机对照试验的系统回顾与荟萃分析DOI: 10.1111/dom.70349 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.51Efficacy and hypoglycaemia outcomes of once-weekly insulin icodec versus once-daily basal insulin comparators across baseline HbA1c, BMI and duration of type 2 diabetes subgroups: A post hoc analysis of ONWARDS 1-5每周一次胰岛素icodec与每天一次基础胰岛素比较药物在不同基线HbA1c、BMI和2型糖尿病病程亚组中的有效性和低血糖结局：ONWARDS 1-5试验的事后分析DOI: 10.1111/dom.70358 Clinical endocrinology IF: 02.400Ahead of Print.No.52"Preventing the Progression: The Power of Lifestyle Interventions in Prediabetic Individuals-A Systematic Review"阻断进展：生活方式干预在糖尿病前期个体中的力量——一项系统综述DOI: 10.1111/cen.70077 Artificial organs IF: 02.300Ahead of Print.No.53Impact of Heart Allocation Change on Selection and Adverse Events of Bridged-To-Transplant Durable Ventricular Assist Device Recipients心脏分配政策变更对移植前桥接用耐久性心室辅助装置患者的选择及不良事件的影响DOI: 10.1111/aor.70042 Diabetic medicine IF: 03.400Ahead of Print.No.54Unmasking the pain in a diabetic foot揭示糖尿病足的疼痛DOI: 10.1111/dme.70166 Journal of neuroendocrinology IF: 04.100Ahead of Print.No.55Human growth hormone-induced mitotic maladaptation in podocytes and implications in diabetic kidney disease生长激素诱导的足细胞有丝分裂适应不良及其在糖尿病肾病中的意义DOI: 10.1111/jne.70122 Clinical endocrinology IF: 02.400Ahead of Print.No.56Real-World Evidence of Long-Term Dulaglutide Use: Sustained Glycemic and Weight Improvements Beyond Three Years度拉糖肽长期使用的真实世界证据：超过三年的持续血糖和体重改善DOI: 10.1111/cen.70078 Clinical genitourinary cancer IF: 02.700Ahead of Print.No.57Toxicity Comparison between a Four-Week Moderate Hypofractionation and a Six-Week Conventional Fractionation in the Post-Prostatectomy Salvage Radiotherapy for Prostate Cancer前列腺癌根治术后挽救性放疗中四周中度大分割与六周常规分割方案的毒性比较DOI: 10.1016/j.clgc.2025.102473 Advanced science IF: 14.100Ahead of Print.No.58Effectiveness of Pre-Transplant Dual GLP-1 Receptor Agonist and SGLT2 Inhibitor Therapy on All-Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target-Trial Emulation移植前GLP-1受体激动剂联合SGLT2抑制剂治疗对伴有肥胖和2型糖尿病的器官移植候选者全因死亡率有效性的目标试验模拟研究DOI: 10.1002/advs.202518813 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.59Beyond surgery: a multimodal framework for a pediatric metabolic and bariatric surgery program in a safety-net children's hospital超越手术：安全网儿童医院儿科代谢与减重手术项目的多模式框架DOI: 10.1016/j.soard.2025.11.011 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.60The value of patient selection in same-day discharge implementation: insights from MBSAQIP database患者选择在当日出院实施中的价值：来自MBSAQIP数据库的见解DOI: 10.1016/j.soard.2025.10.016 Surgery IF: 02.700Ahead of Print.No.61Open, complex abdominal wall reconstruction with synthetic versus biologic mesh: Outcomes with a minimum of 5-year follow-up合成网片与生物网片用于开放复杂腹壁重建的疗效比较：至少5年随访结果DOI: 10.1016/j.surg.2025.109961 Surgery IF: 02.700Ahead of Print.No.62Outcomes among undocumented immigrants undergoing liver transplant: A nationwide retrospective cohort接受肝移植的非法移民患者的结局：一项全国性回顾性队列研究DOI: 10.1016/j.surg.2025.109965 Surgery IF: 02.700Ahead of Print.No.63Retrospective cohort study of launching a new peroral pyloromyotomy practice-A framework for introducing endoscopic surgery within a hospital system关于建立新经口幽门肌切开术实践的回顾性队列研究——医院系统内引入内镜手术的框架DOI: 10.1016/j.surg.2025.109905 BMJ open IF: 02.300Volume 15, Issue 12No.64DIVINE-pilot trial: a phase 2 multicentre, randomised pilot trial of pharmacotherapy and physical activity monitoring conducted in women with recent gestational diabetes and increased risk of type 2 diabetes recruited from tertiary referral hospitals in AustraliaDIVINE-pilot试验：一项在澳大利亚三级转诊医院招募的近期患有妊娠期糖尿病且2型糖尿病风险增加女性中进行的药物疗法和体力活动监测的2期多中心随机试验DOI: 10.1136/bmjopen-2025-107551 BMJ health & care informatics IF: 04.400Volume 32, Issue 1No.65Developing a non-invasive algorithm for the diagnosis of steatotic liver disease in primary healthcare: a retrospective cohort study在初级医疗中开发脂肪性肝病无创诊断算法：一项回顾性队列研究DOI: 10.1136/bmjhci-2025-101620 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.66Transcriptomics analysis unveils the complex interplay between diabetes and hypertension in regulating renal cell carcinoma pathway followed by pancreatic metastasis转录组学分析揭示糖尿病与高血压在调控肾细胞癌通路及后续胰腺转移中的复杂相互作用DOI: 10.1016/j.jgeb.2025.100616 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.67Eco-friendly synthesis of silver nanoparticles from the leaf blades extract of seagrass Thalassia hemprichii: Multifunctional agents for biomedical and environmental applications利用海草Thalassia hemprichii叶片提取物生态友好合成银纳米颗粒：生物医学与环境应用的多功能制剂DOI: 10.1016/j.jgeb.2025.100600 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.68Isolation and characterization of peroxidase from potato leaves Solanum tuberosum: Application in glucose diagnostic kit马铃薯叶过氧化物酶的分离鉴定及其在葡萄糖诊断试剂盒中的应用DOI: 10.1016/j.jgeb.2025.100584 J Genet Eng Biotechnol IF: 02.800Volume 23, Issue 4No.69Loss-of-function variant of SLC30A8 rs13266634 (C > T) protects against type 2 diabetes by stabilizing ZnT8: Insights from epidemiological and computational analysesSLC30A8 rs13266634（C > T）功能缺失变异体通过稳定ZnT8对2型糖尿病具有保护作用：来自流行病学和计算分析的见解DOI: 10.1016/j.jgeb.2025.100565 Surgical infections IF: 01.400Ahead of Print.No.70Multi-factorial Hyperlactatemia Due to Linezolid and Metformin Treatment in the Setting of Vitamin C and B1 Deficiency利奈唑胺与二甲双胍治疗背景下合并维生素C及B1缺乏所致多因素性高乳酸血症DOI: 10.1177/10962964251401522 Proteomics IF: 03.900Ahead of Print.No.71Advancing Understanding of the Protein Composition of Human Seminal Extracellular Vesicles推进对人类精液细胞外囊泡蛋白质组成的理解DOI: 10.1002/pmic.70088 Fam Med Community Health IF: 04.300Volume 13, Issue 4No.72Insights into diabetes remission services: perspectives from general practitioners, family physicians and multidisciplinary teams深入了解糖尿病缓解服务：全科医生、家庭医生和多学科团队的视角DOI: 10.1136/fmch-2025-003631 Am J Med Genet A IF: 01.700Ahead of Print.No.73Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data通过重新分析临床测序数据鉴定CYP11A1复合杂合变异DOI: 10.1002/ajmga.70008 JCE IF: 02.600Ahead of Print.No.74Near-Zero-Fluoroscopy Ablation of Atrial Fibrillation Without ICE or Non-Fluoroscopic Tracking Systems: Findings From the SHORT LOOK Registry不使用ICE或非透视跟踪系统的近零透视心房颤动消融：SHORT LOOK注册研究结果DOI: 10.1111/jce.70225 Int J Biol Macromol IF: 08.500Ahead of Print.No.75Fabrication of ferulic acid-decorated ZnO nanoparticles in a chitosan matrix: A bioactive powder for wound management阿魏酸修饰的ZnO纳米颗粒在壳聚糖基质中的制备：一种用于伤口管理的生物活性粉末DOI: 10.1016/j.ijbiomac.2025.149640 Canadian journal of diabetes IF: 02.600Ahead of Print.No.76Optimizing patient partner engagement and integration in research: Recommendations from a qualitative study of focus groups with patient partners living with type 1 or type 2 diabetes优化研究中患者伙伴的参与和整合：来自1型或2型糖尿病患者伙伴焦点小组定性研究的建议DOI: 10.1016/j.jcjd.2025.12.002 Biochimie IF: 03.000Ahead of Print.No.77A comprehensive review on the Advanced Glycation End Products detection: From conventional to advanced approaches晚期糖基化终末产物检测方法综述：从传统到先进手段DOI: 10.1016/j.biochi.2025.12.004 Ann Allergy Asthma Immunol IF: 04.700Ahead of Print.No.78Gestational diabetes and childhood lung function at age 8-9 years in a diverse US cohort美国一项多样族裔队列研究表明：妊娠期糖尿病与8-9岁儿童肺功能下降相关DOI: 10.1016/j.anai.2025.12.006 Exp Clin Endocrinol Diabetes IF: 01.700Ahead of Print.No.79Association of fibrosis index-4 (FIB-4) with chronic vascular complications of type 2 diabetes mellitus纤维化指数-4（FIB-4）与2型糖尿病慢性血管并发症的关联DOI: 10.1055/a-2765-6480 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.80Assessing the quality and guideline-concordance of AI-powered chatbots in nutritional management of diabetes评估AI驱动聊天机器人在糖尿病营养管理中的质量与指南一致性DOI: 10.1016/j.dsx.2025.103355 Tissue & cell IF: 02.500Ahead of Print.No.81Membrane-engineered Wharton's Jelly derived mesenchymal stem cells with anti-CD2 antibody coating modulate activated CD3(+) T-cell responses膜工程化沃顿胶来源间充质干细胞联合抗CD2抗体涂层调节活化CD3(+) T细胞应答DOI: 10.1016/j.tice.2025.103274 Journal of plant physiology IF: 04.100Ahead of Print.No.82Triumphing over hidden hunger: Redesigning rice (Oryza sativa L.) for enhanced nutraceutical grain composition utilizing multiplexed genome editing战胜隐性饥饿：利用多重基因组编辑技术改良水稻的保健谷物成分DOI: 10.1016/j.jplph.2025.154667 JMIR research protocols IF: 01.500Volume 14, Issue No.83Co-Design of a Digital Health Platform for Chronic Disease Management in Rural Settings Using a Person-Centered, Collaborative-Care Model: Protocol for a 3-Phase Mixed Methods Study采用以人为本、协作护理模式在农村环境中共同设计慢性病管理数字健康平台：一项三阶段混合方法研究方案DOI: 10.2196/77844 PloS one IF: 02.600Volume 20, Issue 12No.84Hyperglycemia and bladder cancer prognosis in a Finnish population-based cohort高血糖与芬兰人群队列中膀胱癌预后的关系DOI: 10.1371/journal.pone.0338215 Advances in physiology education IF: 01.700Ahead of Print.No.85Endometriosis: Pathophysiology and the Potential Role of Diet子宫内膜异位症：病理生理学与饮食的潜在作用DOI: 10.1152/advan.00198.2025 Pancreas IF: 01.700Ahead of Print.No.86Internet-delivered Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: A Multicenter Randomized Controlled Trial针对儿童急性复发性及慢性胰腺炎疼痛的互联网提供认知行为干预：一项多中心随机对照试验DOI: 10.1097/MPA.0000000000002558 Cell reports IF: 06.900Ahead of Print.No.87VIP interneuron activity during sleep conveys the cortical infraslow oscillation睡眠中VIP中间神经元的活动传导皮层超慢振荡DOI: 10.1016/j.celrep.2025.116669 The Journal of frailty & aging IF: 03.300Ahead of Print.No.88Association between diabetes and frailty, and the moderating role of sex in that association in older adults of the ELSA-Brasil study老年糖尿病与衰弱的关系及性别在其中的调节作用：ELSA-Brasil研究DOI: 10.1016/j.tjfa.2025.100115 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.89Efficacy, Mechanisms and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients: A Randomized, Double-Blind, Placebo-Controlled Trial钠-葡萄糖协同转运蛋白2抑制剂在肾移植受者中的有效性、机制与安全性：一项随机、双盲、安慰剂对照试验DOI: 10.2215/CJN.0000000951 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.90Comparison of Low eGFR Prevalence and Prediction for Mortality Using 2009 and 2021 CKD-EPI Equations in Mexican Adults使用2009与2021年CKD-EPI方程比较墨西哥成人中低eGFR患病率及其对死亡率的预测价值DOI: 10.2215/CJN.0000000933 PloS one IF: 02.600Volume 20, Issue 12No.91Mapping the microRNA-mediated crosstalk between insulin resistance and Alzheimer's disease: A computational genomic insight绘制胰岛素抵抗与阿尔茨海默病之间由microRNA介导的交互作用图谱：一项计算基因组学视角DOI: 10.1371/journal.pone.0329056 Cell reports IF: 06.900Ahead of Print.No.92DEC1 regulates human β cell functional maturation and circadian rhythmDEC1调控人类β细胞功能成熟与昼夜节律DOI: 10.1016/j.celrep.2025.116666 Kidney360 IF: 03.000Ahead of Print.No.93Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease常染色体显性多囊肾病的新兴疗法DOI: 10.34067/KID.0000001109 Appl Physiol Nutr Metab IF: 02.000Ahead of Print.No.94Bottle to Body: How Multivitamin/Mineral Supplements Shape Canadian Nutrient Intake从补充剂到身体：复合维生素/矿物质补充剂如何影响加拿大人的营养摄入DOI: 10.1139/apnm-2025-0305 Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.95RYGB Induces Vagal Sensory Neuropathy Characterized by Altered GLP1R Expression and Enhanced Exendin-4 Responsiveness in Male Mice胃旁路术诱导迷走神经感觉神经病变，其特征为GLP1R表达改变和Exendin-4反应性增强DOI: 10.1152/ajpendo.00452.2025 AIDS care IF: 01.200Ahead of Print.No.96Association between diet quality, physical activity and anthropometric status of people living with HIV in Cape Town开普敦HIV感染者的饮食质量、体力活动与人体测量学状况之间的关联DOI: 10.1080/09540121.2025.2586244 PloS one IF: 02.600Volume 20, Issue 12No.97Public knowledge and awareness of obstructive sleep apnea in Saudi Arabia: A population-based study of over 16,000 adults沙特阿拉伯公众对阻塞性睡眠呼吸暂停的知识与认知：一项基于超过1.6万名成年人的群体研究DOI: 10.1371/journal.pone.0337822 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.98Sodium-Glucose Cotransporter-2 Inhibitors and Ketoacid Diets for Diabetic Kidney Disease钠-葡萄糖协同转运蛋白-2抑制剂与酮酸饮食治疗糖尿病肾病DOI: 10.2215/CJN.0000000958 Kidney360 IF: 03.000Ahead of Print.No.99Targeting αvβ8 Integrin with Monoclonal Antibody MEDI8367 Prevents Fibrosis in Preclinical Models of CKD单克隆抗体MEDI8367靶向αvβ8整合素可在慢性肾病临床前模型中预防纤维化DOI: 10.34067/KID.0000001006 Journal of medicinal chemistry IF: 06.800Ahead of Print.No.100Design, Optimization, and Biological Evaluation of First-in-Class Triple Inhibitors of SGLT1, SGLT2, and DPP4 for Type 2 Diabetes Mellitus针对2型糖尿病的SGLT1、SGLT2与DPP4三重抑制剂的研发、优化与生物学评价DOI: 10.1021/acs.jmedchem.5c02225 PloS one IF: 02.600Volume 20, Issue 12No.101Shift from visceral to subcutaneous adipose tissue in Cyp17a1-knockout rats prevents the progression of metabolic syndromeCyp17a1基因敲除大鼠脂肪从内脏向皮下转移阻止代谢综合征进展DOI: 10.1371/journal.pone.0311478 Fundam Clin Pharmacol IF: 02.500Volume 40, Issue 1No.102Gabapentinoids and Neuropathic Pain: Evaluation of the Quality of Randomised Controlled Trials: An Umbrella Review加巴喷丁与神经病理性疼痛：随机对照试验质量的评估：一项伞状评价DOI: 10.1111/fcp.70052 J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.103A Scoping Review of Racial Identity, Racial Socialization, and Africentric Worldview in the Context of Obesity in Black Adolescent Females黑人少女肥胖背景下的种族认同、种族社会化与非洲中心世界观：一项范围综述DOI: 10.1007/s40615-025-02678-1 Matern Child Health J IF: 01.700Ahead of Print.No.104Low Calcium Intake in High-Risk Pregnant Women: What are the Associated Factors?高危孕妇钙摄入不足：相关因素有哪些？DOI: 10.1007/s10995-025-04200-9 Hernia IF: 02.400Volume 30, Issue 1No.105Enhancing prediction of incisional hernia in liver transplant patients: performance assessment and stepwise revision of a prognostic model提升肝移植患者切口疝的预测能力：一项预后模型的性能评估与逐步修订DOI: 10.1007/s10029-025-03508-3 West J Nurs Res IF: 01.700Ahead of Print.No.106Factors Related to Binge Eating in Korean American Women韩国裔美国女性暴食相关因素研究DOI: 10.1177/01939459251391989 Endocrine connections IF: 02.800Ahead of Print.No.107Short-term changes in des-acyl ghrelin following bariatric surgery减重手术后脱酰基生长激素释放肽的短期变化DOI: 10.1530/EC-25-0325 Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.108[Effective management of biological age and quality of life in patients based on the integrated use of pathogenetically focused medical rehabilitation methods]基于病理生理学导向医疗康复方法整合应用有效管理患者生物学年龄与生活质量DOI: 10.17116/kurort202510205281 Vopr Kurortol Fizioter Lech Fiz KultVolume 102, Issue 5. Vyp. 2No.109[The informative value of methods for diagnosing aging and the development of prognostic criteria for the effectiveness of complex physiotherapy for managing active longevity]诊断衰老方法的信息价值及制定综合物理疗法管理积极长寿疗效的预后标准DOI: 10.17116/kurort202510205235 Cancer prevention research IF: 02.600Ahead of Print.No.110Uncovering the Red Flags: A Cross-Sectional Retrospective Case-Control Study on Predictors of Early Onset Colorectal Cancer in a Multi-State Community Health System揭示危险信号：一项多州社区医疗系统中早发性结直肠癌预测因素的横断面回顾性病例对照研究DOI: 10.1158/1940-6207.CAPR-25-0232 Indian Journal of Ophthalmology IF: 01.800Ahead of Print.No.111Ocular warnings of a silent killer: A case series on intracranial aneurysms无声杀手的眼部预警：颅内动脉瘤病例系列研究DOI: 10.4103/IJO.IJO_1543_25 J Endocrinol Invest IF: 03.500Ahead of Print.No.112Circulating 1,5-anhydroglucitol levels combined with pre-pregnancy BMI is a simple predictive marker of future glucose intolerance in women with gestational diabetes循环1,5-脱水葡萄糖醇水平联合孕前BMI是妊娠糖尿病女性未来葡萄糖不耐受的简单预测标志物DOI: 10.1007/s40618-025-02768-1 Diabetologia IF: 10.200Ahead of Print.No.113Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk. Reply to Choi W [Letter]基于正常血糖与糖尿病前期不同定义评估从糖尿病前期回归正常血糖状态对降低2型糖尿病风险的估计影响——答Choi W来信DOI: 10.1007/s00125-025-06641-x European journal of pediatrics IF: 02.600Volume 185, Issue 1No.114About potential value and limitations of continuous glucose monitoring in DKA连续葡萄糖监测在糖尿病酮症酸中毒中的潜在价值与局限性探讨DOI: 10.1007/s00431-025-06684-7 Indian journal of pediatrics IF: 02.000Ahead of Print.No.115Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India北印度1型糖尿病患者胰岛自身抗体模式、持续性及其免疫遗传学关联DOI: 10.1007/s12098-025-05882-3 Obesity surgery IF: 03.100Ahead of Print.No.116Correction: Metabolic Surgery for Obese Type 2 Diabetes: Korean Multicenter Cohort Study代谢外科手术治疗肥胖型2型糖尿病：韩国多中心队列研究DOI: 10.1007/s11695-025-08413-3 Hernia IF: 02.400Volume 30, Issue 1No.117Factors associated with venous thromboembolism in retromuscular ventral hernia repair - an abdominal core health quality collaborative analysis腹后间隙腹疝修补术中静脉血栓栓塞的相关因素分析——基于腹壁核心健康质量协作组数据库的研究DOI: 10.1007/s10029-025-03530-5 HNO IF: 01.300Ahead of Print.No.118[Diagnosis and management of necrotizing otitis externa]坏死性外耳道炎的诊断与管理DOI: 10.1007/s00106-025-01690-5 Diabetes IF: 07.500Ahead of Print.No.119miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in MicemiR-494缺失独立于肥胖改善小鼠葡萄糖代谢DOI: 10.2337/db25-0355 Endocrine connections IF: 02.800Volume 14, Issue 12No.120Diagnostic accuracy of the triptorelin stimulation test for central precocious puberty in girls曲普瑞林刺激试验对女孩中枢性性早熟的诊断准确性DOI: 10.1530/EC-25-0642 Nephrol Dial Transplant IF: 05.600Ahead of Print.No.121Fasting urine osmolality and risk of kidney disease progression in patients with type 2 diabetes空腹尿渗透压与2型糖尿病患者肾脏疾病进展风险的关系DOI: 10.1093/ndt/gfaf264 Biomaterials science IF: 05.700Ahead of Print.No.122Bioresorbable-bioactive auxetic "personalised" phalanx with a CT-guided AI-driven model towards in vivo prediction of bone regeneration生物可吸收-生物活性拉胀结构“个性化”指骨：一种基于CT引导和AI驱动的模型，用于体内骨再生预测DOI: 10.1039/d5bm01337b Health promotion international IF: 02.400Volume 40, Issue 6No.123An exploration of cultural grounding in Indigenous health promotion: perspectives from First Nations communities in Canada探索土著健康促进中的文化根基：来自加拿大原住民社区的视角DOI: 10.1093/heapro/daaf211 MS. Me?decine sciences IF: 00.400Volume 41, Issue 11No.124[Cell therapy of diabetes in France: from islet transplantation to future perspectives]法国糖尿病细胞疗法：从胰岛移植到未来展望DOI: 10.1051/medsci/2025161 J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.125Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease振动控制瞬时弹性成像技术在儿科代谢功能障碍相关脂肪性肝病中的应用DOI: 10.1002/jpn3.70284 European thyroid journal IF: 04.300Ahead of Print.No.126Selenium supplementation in individuals with newly diagnosed Graves' hyperthyroidism: A double-blind, multi-centre RCT新诊断Graves甲状腺功能亢进症患者的硒补充：一项双盲、多中心随机对照试验DOI: 10.1530/ETJ-25-0264 Acta Bioeng Biomech IF: 00.800Volume 27, Issue 3No.127A novel data mining approach for early diagnosis of gestational diabetes mellitus (GDM) in pregnancy via machine learning methods and CNN通过机器学习方法与CNN实现妊娠期糖尿病（GDM）早期诊断的一种新型数据挖掘方法DOI: 10.37190/abb/209528 Monaldi Arch Chest Dis IF: 01.100Ahead of Print.No.128Coronary plaques and pericardial fat volume assessment in patients with metabolic syndrome being evaluated for suspected coronary artery disease代谢综合征疑诊冠心病患者冠状动脉斑块特征与心包脂肪体积的评估DOI: 10.4081/monaldi.2025.3390 Am J Gastroenterol IF: 07.600Ahead of Print.No.129Glucagon-like peptide-1 receptor agonist treatment and risk of esophageal cancer胰高血糖素样肽-1受体激动剂治疗与食管癌风险DOI: 10.14309/ajg.0000000000003885 Endocrine connections IF: 02.800Ahead of Print.No.130Changes in Fibroblast Growth Factor 21 Levels Associated with Alcohol Consumption and Smoking Cessation与饮酒和戒烟相关的成纤维细胞生长因子21水平变化DOI: 10.1530/EC-25-0713 Daru IF: 02.100Volume 34, Issue 1No.131Resveratrol and caffeic acid attenuate diet-induced obesity by inhibiting the SREBP-1/ACLY lipogenic axis in adipose tissue of rats白藜芦醇与咖啡酸通过抑制脂肪组织中的SREBP-1/ACLY脂生成轴来减轻大鼠饮食诱导的肥胖DOI: 10.1007/s40199-025-00582-x Am J Gastroenterol IF: 07.600Ahead of Print.No.132Poor Sensitivity of the Fatty Liver Index Among Lean Individuals脂肪肝指数在瘦人中的敏感性较差DOI: 10.14309/ajg.0000000000003883 Assist Inferm Ric IF: 00.900Volume 44, Issue 4No.133[Obesity as a chronic disease: the key role of new therapies]肥胖作为慢性疾病：新疗法的关键作用DOI: 10.1702/4616.46253 Pregnancy Hypertension IF: 02.900Volume 43, Issue No.134The impact of maternal chronic hypertension in pregnancy on offspring long-term respiratory morbidity妊娠期母亲慢性高血压对后代长期呼吸系统发病率的影响DOI: 10.1016/j.preghy.2025.101405 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.135P021 A case of radiation-induced haemorrhagic bullous lichen sclerosus of the breast一例乳腺癌放疗后诱发的出血性大疱性硬化性苔藓病例DOI: 10.1093/bjd/ljaf085.049 Frontiers in pharmacology IF: 04.800Volume 16, Issue No.136Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand积雪草（Centella asiatica (L.) Urb. [Apiaceae]）作为膳食补充剂用于2型糖尿病患者血糖控制与血脂调节的有效性与安全性：一项泰国随机对照试验DOI: 10.3389/fphar.2025.1680647 Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.137The influence of diabetes mellitus on blood vessels' amounts and immune status in case of breast cancer糖尿病对乳腺癌患者血管数量及免疫状态的影响DOI: 10.47162/RJME.66.3.12 Plant Physiol Biochem IF: 05.700Volume 229, Issue Pt CNo.138Encapsulated GABA coatings as a postharvest strategy to enhance mango chilling tolerance包封GABA涂层作为增强芒果采后耐冷性的策略DOI: 10.1016/j.plaphy.2025.110644 Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.139Quality of Life and Diabetic Complications Among Type 2 Diabetes Patients Across Healthcare Levels in Bandung, Indonesia印尼万隆市不同医疗层级2型糖尿病患者的生活质量与糖尿病并发症DOI: 10.2147/DMSO.S549279 Biology open IF: 01.700Ahead of Print.No.140miR-302 regulates pancreatic progenitor pool and pancreatic sizemiR-302调控胰腺祖细胞池与胰腺大小DOI: 10.1242/bio.062353 Transplant international IF: 03.000Volume 38, Issue No.141Death and Graft Loss in Simultaneous Pancreas-Kidney Recipients by Donor-Recipient Cytomegalovirus Serostatus in the United States基于供受者巨细胞病毒血清状态的美国同期胰腺-肾移植受者死亡与移植物丢失分析DOI: 10.3389/ti.2025.15653 Frontiers in health services IF: 02.700Volume 5, Issue No.142The DIAMONDS intervention for type 2 diabetes for people with severe mental illness: findings from a single-group feasibility study针对严重精神疾病患者的2型糖尿病DIAMONDS干预措施：单组可行性研究结果DOI: 10.3389/frhs.2025.1688787 J Biostat Biom ApplVolume 9, Issue 1No.143Factors Affecting Time to Return to a Normal Level of Hba1c Among Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia影响糖尿病患者糖化血红蛋白恢复至正常水平时间的因素https://pubmed.ncbi.nlm.nih.gov/41384241 Curēus IF: 01.300Volume 17, Issue 11No.144Evaluation of the Analytical Performance of a High-Precision Immunoassay for the Creatine Kinase-MB Isoenzyme高精度肌酸激酶-MB同工酶免疫测定方法的分析性能评估DOI: 10.7759/cureus.96457 Curēus IF: 01.300Volume 17, Issue 11No.145Unlocking the Potential of Negative Pressure Wound Therapy in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis解锁负压伤口疗法在糖尿病足溃疡中的潜力：一项系统综述与荟萃分析DOI: 10.7759/cureus.96474 Frontiers in oral health IF: 03.100Volume 6, Issue No.146Dental implant failure and retrieval techniques; a scoping review种植牙失败与取出技术：一项范围性综述DOI: 10.3389/froh.2025.1667808 JCEM case reportsVolume 4, Issue 1No.147Central Precocious Puberty and Hypothalamic Teratoma中枢性性早熟与下丘脑畸胎瘤DOI: 10.1210/jcemcr/luaf275 Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.148Relationship between thyroid nodule, prolactin, and thyroid peroxidase antibody levels: A case-control study甲状腺结节、泌乳素与甲状腺过氧化物酶抗体水平的关系：一项病例对照研究DOI: 10.22088/cjim.16.4.712 bioRxivVolume 2025, Issue No.149EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS不同钙负荷人体股腘动脉中球囊血管成形术的实验特征DOI: 10.1101/2025.11.27.691029 Clinical case reports IF: 00.600Volume 13, Issue 12No.150Myiasis of the Mastoid Cavity: Case Report乳突腔蝇蛆病：病例报告DOI: 10.1002/ccr3.71671 NeuroprotectionVolume 3, Issue 1No.151Decoding the role of large heat shock proteins in the progression of neuroinflammation-mediated neurodegenerative disorders解码大热休克蛋白在神经炎症介导的神经退行性疾病进展中的作用DOI: 10.1002/nep3.68 Skin appendage disorders IF: 01.300Ahead of Print.No.152Retrospective Analysis of Nail Changes and Comorbidities in Darier Disease达里埃病甲改变与合并症的回顾性分析DOI: 10.1159/000549631 Frontiers in nutrition IF: 05.100Volume 12, Issue No.153Consumption of commercial and traditional sugar-sweetened beverages among adolescents in Pakistan: evidence from a national survey巴基斯坦青少年商业和传统含糖饮料消费情况：基于全国调查的证据DOI: 10.3389/fnut.2025.1679917 Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.154[Factors associated with cardiometabolic disease screening in older adults in the Peruvian AmazonFatores associados ao rastreamento de doenças cardiometabólicas em pessoas idosas da Amazônia peruana]秘鲁亚马逊地区老年人心脏代谢疾病筛查的相关因素分析DOI: 10.26633/RPSP.2025.118 Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.155[Implementation of hypertension and diabetes care pathways in two regions of the Brazilian NortheastImplementación de las líneas de cuidado para la hipertensión y la diabetes en dos regiones del nordeste brasileño]巴西东北部两个地区高血压与糖尿病护理路径的实施DOI: 10.26633/RPSP.2025.117 Rev Panam Salud Publica IF: 02.200Volume 49, Issue No.156[Nursing consultations in primary health care in Brazil: distribution and productivity in the management of chronic noncommunicable diseasesConsultas atendidas por personal de enfermería en la atención primaria de salud en Brasil: distribución y productividad en las consultas relativas a enfermedades crónicas no transmisibles]巴西初级卫生保健中的护理咨询：慢性非传染性疾病管理的分布与生产率DOI: 10.26633/RPSP.2025.115 Sage open agingVolume 11, Issue No.157Factors Associated With Subjective Wellbeing in Community-Dwelling Homebound Older Adults With Diabetes in the US美国居家不便老年糖尿病患者主观幸福感的相关因素研究DOI: 10.1177/30495334251404290 Frontiers in neurology IF: 02.800Volume 16, Issue No.158SAFE-CGRP study: multicenter retrospective evaluation of the safety of CGRP pathway-targeting monoclonal antibodies in migraine with relevant comorbidities or conditions excluded from trialsSAFE-CGRP研究：针对CGRP通路单克隆抗体在具有临床试验排除的相关合并症偏头痛患者中的多中心回顾性安全性评价DOI: 10.3389/fneur.2025.1703876 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.159Creation and Evaluation of a Research Participant Portal for the University of Chicago Monogenic Diabetes Registry创建和评估芝加哥大学单基因糖尿病注册研究参与者门户DOI: 10.1177/19322968251399666 Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.160Leveraging artificial intelligence for cardiovascular risk: a primary care perspective基于人工智能的心血管风险评估：来自初级医疗的视角DOI: 10.47162/RJME.66.3.13 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.161P082 The WHO-5 wellbeing measure as an assessment tool in inflammatory skin diseasesWHO-5幸福感量表作为炎症性皮肤病的评估工具DOI: 10.1093/bjd/ljaf085.110 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.162P105 Lebrikizumab improves quality of life and wellbeing of patients with moderate-to-severe atopic dermatitis inadequately controlled with or ineligible for ciclosporin: German extension results (week 76) of the ADvantage studyLebrikizumab改善对环孢素控制不佳或不适合使用的中重度特应性皮炎患者的生活质量及幸福感：ADvantage研究德国延长期（第76周）结果DOI: 10.1093/bjd/ljaf085.133 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.163BH20 A multicentre analysis of the adequacy of alopecia horizontal biopsy samples over 10 years一项十年期多中心分析：脱发水平活检样本的充分性DOI: 10.1093/bjd/ljaf085.241 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.164O05 A retrospective review of cases of psoriasis requiring discontinuation of biologic therapy from 2007 to 2024 in a multisite NHS trust一项对2007年至2024年间多中心NHS信托银屑病需停用生物制剂病例的回顾性研究DOI: 10.1093/bjd/ljaf085.020 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.165BG12 Carotenaemia: a persistent orange hueBG12 胡萝卜素血症：一种持续性的橙色调DOI: 10.1093/bjd/ljaf085.358 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.166CPC12 An unusual case of paraneoplastic sarcoid presenting as dactylitis病例报告12：表现为指趾炎的副肿瘤性结节病一例DOI: 10.1093/bjd/ljaf085.012 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.167BH13 Itchy feet: skin and nail conditions in the podiatrists' clinic足部瘙痒：足病诊所中的皮肤与指甲问题DOI: 10.1093/bjd/ljaf085.234 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.168PA43 An infrequently diagnosed cause of pruritusPA43 一个罕见诊断的瘙痒病因DOI: 10.1093/bjd/ljaf085.402 The annals of pharmacotherapy IF: 02.300Ahead of Print.No.169Vildagliptin-Associated Acquired Hemophilia A维格列汀相关的获得性血友病ADOI: 10.1177/10600280251403095 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.170P110 Low prevalence of liver fibrosis in patients with atopic dermatitis on methotrexate甲氨蝶呤治疗的特应性皮炎患者肝纤维化患病率较低DOI: 10.1093/bjd/ljaf085.138 Plastic surgery IF: 00.600Ahead of Print.No.171Effect of Body Contouring Procedures on Changes in Long-Term Weight and Metabolic Health身体轮廓整形手术对长期体重及代谢健康变化的影响DOI: 10.1177/22925503251400374 Health science reports IF: 02.100Volume 8, Issue 12No.172Comparative Effectiveness of Insulin Versus Oral Hypoglycemic Agents in Diabetic Patients With Acute Stroke: A Retrospective Cross-Sectional Analysis of Treatment Outcomes and Influencing Factors胰岛素与口服降糖药在伴有急性卒中的糖尿病患者中的疗效比较：治疗结局及影响因素的回顾性横断面分析DOI: 10.1002/hsr2.71598 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.173SG02 Transdermal testosterone improves lower-extremity ulceration in a young man with newly diagnosed Klinefelter syndrome (47 XXY)经皮睾酮改善新诊断47XXY克氏综合征年轻男性下肢溃疡DOI: 10.1093/bjd/ljaf085.511 Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.174Association of celiac disease with type 1 diabetes: A cross-sectional analysis in 2022乳糜泻与1型糖尿病的关联：一项2022年的横断面分析DOI: 10.22088/cjim.16.4.797 Pediatric diabetes IF: 05.600Volume 2025, Issue No.175Exploring the Influence of a Diabetes Specialty Outpatient Clinic on Adolescents With Type 1 Diabetes in Barbados: A Qualitative Study探索巴巴多斯糖尿病专科门诊对1型糖尿病青少年的影响：一项定性研究DOI: 10.1155/pedi/5454172 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.176CD02 Colophonium derivatives as key allergens in diabetes technology-associated allergic contact dermatitis: a hidden concern in the British Society for Cutaneous Allergy standard seriesCD02：松香衍生物是糖尿病技术相关过敏性接触性皮炎的关键过敏原——英国皮肤过敏学会标准系列中的一个隐忧DOI: 10.1093/bjd/ljaf085.271 Frontiers in physiology IF: 03.400Volume 16, Issue No.177Impact of vascular density on pancreatic islet viability: a computational study血管密度对胰岛细胞活力的影响：一项计算研究DOI: 10.3389/fphys.2025.1707026 RSC advances IF: 04.600Volume 15, Issue 57No.178Nanoliposome-based drug delivery systems for the treatment of diabetes mellitus: a review糖尿病治疗：纳米脂质体药物递送系统综述DOI: 10.1039/d5ra07152f Frontiers in endocrinology IF: 04.600Volume 16, Issue No.179Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes氧化应激的疤痕：蛋白羰基化与糖尿病中的β细胞功能障碍DOI: 10.3389/fendo.2025.1722623 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.180The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women与血糖正常女性相比，糖尿病前期女性中多囊卵巢综合征的发生率DOI: 10.3389/fendo.2025.1722978 Veterinary medicine and science IF: 01.700Volume 12, Issue 1No.181Effect of Feeding Cottonseed Meal With or Without NSP Enzymes on Growth Performance, Blood Biochemistry, Growth-Related Gene Expression, Intestinal Health and Economic Efficiency in Broilers饲喂添加或不添加NSP酶的棉籽粕对肉鸡生长性能、血液生化、生长相关基因表达、肠道健康和经济效率的影响DOI: 10.1002/vms3.70723 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.182CD19 Contact allergy to colophonium and Abitol in a continuous glucose monitor securing tapeCD19 对连续血糖监测仪固定胶带中松香和松香醇的接触性过敏DOI: 10.1093/bjd/ljaf085.288 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.183P024 Anakinra for recalcitrant pyoderma gangrenosum with Achilles tendon exposureP024 阿那白滞素治疗伴跟腱暴露的顽固性坏疽性脓皮病DOI: 10.1093/bjd/ljaf085.052 Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.184Association between triglyceride-glucose index and nephrolithiasis among the elderly in Amirkola: A cross-sectional population-based studyAmirkola地区老年人群甘油三酯-葡萄糖指数与肾结石的关联：一项基于人群的横断面研究DOI: 10.22088/cjim.16.4.741 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.185Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort美国队列研究：17β-雌二醇主导的性别肯定激素治疗对内脏脂肪组织及肝脏脂肪的影响DOI: 10.1210/clinem/dgaf665 BioFactors IF: 05.000Volume 51, Issue 6No.186Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro-Tumor Properties to Adipocytes by Stimulating Lipolysis前列腺癌细胞释放的胞外囊泡通过刺激脂解作用赋予脂肪细胞促肿瘤特性DOI: 10.1002/biof.70067 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.187PA41 Treating severe nodulocystic acne with isotretinoin in children with cystic fibrosis使用异维A酸治疗囊性纤维化儿童的严重结节囊肿性痤疮DOI: 10.1093/bjd/ljaf085.400 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.188P070 Effect of insulin resistance on treatment response in moderate-to-severe psoriasis: a retrospective study胰岛素抵抗对中重度银屑病治疗效果的影响：一项回顾性研究DOI: 10.1093/bjd/ljaf085.098 Journal of diabetes research IF: 03.400Volume 2025, Issue No.189Longitudinal Study on the Progression of Diabetes Mellitus Patients at Jimma University Specialized Hospital, Ethiopia埃塞俄比亚Jimma大学专科医院糖尿病患者的纵向研究DOI: 10.1155/jdr/7035393 Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.190Carotid sonographic features in Takayasu's arteritis: A case-control study高安动脉炎的颈动脉超声特征：一项病例对照研究DOI: 10.22088/cjim.16.4.747 NeuroprotectionVolume 3, Issue 2No.191Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease从β细胞到脑细胞：胰岛素与葡萄糖代谢在阿尔茨海默病中的关键作用DOI: 10.1002/nep3.70008 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.192BC06 Investigating the role of metformin in melasma management: a review探究二甲双胍在黄褐斑管理中的作用：一篇综述DOI: 10.1093/bjd/ljaf085.219 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.193P111 A multicentre service evaluation highlighting the variable off-label prescribing practice of spironolactone in the management of hidradenitis suppurativa: the need for evidence-based guidelines一项多中心服务评估揭示螺内酯治疗化脓性汗腺炎的标签外处方实践差异显著：凸显循证指南的必要性DOI: 10.1093/bjd/ljaf085.139 Curēus IF: 01.300Volume 17, Issue 11No.194Initial Institutional Experience and Workflow of Biology-Guided Radiotherapy (BgRT) for a Patient With Non-small Cell Lung Cancer针对非小细胞肺癌患者的生物引导放疗（BgRT）：机构初步经验与工作流程DOI: 10.7759/cureus.96513 Frontiers in digital health IF: 03.800Volume 7, Issue No.195Dissecting the difference between positive and negative brain health sentiment using X data剖析X平台数据中脑健康正负面情绪差异DOI: 10.3389/fdgth.2025.1648671 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.196PS11 Successful treatment of chronic pruritus and secondary ulceration with aprepitant阿瑞匹坦成功治疗慢性瘙痒和继发性溃疡DOI: 10.1093/bjd/ljaf085.509 Eur J Transl Myol IF: 01.800Ahead of Print.No.197Analysis of the Effects of Dapagliflozin on Cardiac Myocyte Injury Markers and Left Ventricular Diastolic Function in Heart Failure Patients with Preserved Ejection Fraction after PCI达格列净对PCI术后射血分数保留心力衰竭患者心肌损伤标志物及左心室舒张功能的影响分析DOI: 10.4081/ejtm.2025.14272 Clinical ophthalmology IF: 02.200Volume 19, Issue No.198Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study垂体腺瘤视通路压迫的结构与功能转归：一项前瞻性OCT试点研究DOI: 10.2147/OPTH.S556193 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.199P121 Treatment with semaglutide improves the systemic inflammatory burden associated with hidradenitis suppurativa司美格鲁肽治疗改善化脓性汗腺炎相关的全身炎症负担DOI: 10.1093/bjd/ljaf085.149 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.200BH10 Nailing the diagnosis从指甲入手明确诊断DOI: 10.1093/bjd/ljaf085.231 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.201DP11 A case of Langerhans cell histiocytosis masquerading as lymphocytic hypophysitis and panhypopituitarism伪装成淋巴细胞性垂体炎和全垂体功能减退症的朗格汉斯细胞组织细胞增生症一例DOI: 10.1093/bjd/ljaf085.334 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.202BI34 Scleromyxoedema in pregnancy: a rare and complex case妊娠合并硬化性粘液水肿：一例罕见复杂病例DOI: 10.1093/bjd/ljaf085.443 Curēus IF: 01.300Volume 17, Issue 11No.203Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors and Risk of Heart Failure Hospitalization in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials钠-葡萄糖协同转运蛋白-2抑制剂与2型糖尿病患者心衰住院风险：一项随机对照试验的系统回顾与荟萃分析DOI: 10.7759/cureus.96456 bioRxivVolume 2025, Issue No.204Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism疾病相关的STAT5B SH2结构域突变重编程肝脏胆固醇和脂质代谢DOI: 10.1101/2025.11.27.691004 In silico pharmacologyVolume 14, Issue 1No.205In vitro and computational evaluation of the erectogenic and anti-diabetic potential of ethanol extract of Hymenodictyon pachyantha stem barkHymenodictyon pachyantha茎皮乙醇提取物在体外和计算层面的勃起及抗糖尿病潜力评估DOI: 10.1007/s40203-025-00510-6 Curēus IF: 01.300Volume 17, Issue 11No.206Unexpected Electroencephalogram Activity in a Brain-Dead Organ Donor: A Case Report一例脑死亡器官捐献者中的意外脑电图活动DOI: 10.7759/cureus.96488 Curēus IF: 01.300Volume 17, Issue 11No.207Determinants of Hypertension Among Transport Workers in Ibadan, Nigeria: A Structural Equation Modeling Approach尼日利亚伊巴丹市运输工人高血压的影响因素：一项结构方程模型方法研究DOI: 10.7759/cureus.96458 Frontiers in endocrinology IF: 04.600Volume 16, Issue No.208Vitamin D supplementation and its impact on leptin and interleukin-6 in women following religious intermittent fasting: a controlled study维生素D补充对遵循宗教间歇性禁食女性瘦素和白介素-6的影响：一项对照研究DOI: 10.3389/fendo.2025.1700844 Caspian J Intern Med IF: 01.000Volume 16, Issue 4No.209Association between osteoporosis and symptomatic knee osteoarthritis in postmenopausal women: A case-control study绝经后女性骨质疏松与症状性膝骨关节炎的关联：一项病例对照研究DOI: 10.22088/cjim.16.4.686 bioRxivVolume 2025, Issue No.210Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD肝细胞MLKL通过不依赖坏死性凋亡的线粒体功能障碍驱动肥胖相关的代谢功能障碍相关脂肪性肝病性肝细胞癌进展DOI: 10.1101/2025.11.26.690789 Frontiers in pediatrics IF: 02.000Volume 13, Issue No.211Influence of gestational history on neural tube defects and Eisenmenger syndrome: associations with intellectual disability and visual impairment in children and adults - a systematic review妊娠史对神经管缺陷和艾森曼格综合征的影响：与儿童及成人智力障碍和视力障碍的关联——一项系统综述DOI: 10.3389/fped.2025.1522839 Clinical case reports IF: 00.600Volume 13, Issue 12No.212Comorbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Chung-Jansen Syndrome: Case Report and Review of Literature注意缺陷多动障碍与钟-詹森综合征共病：病例报告及文献回顾DOI: 10.1002/ccr3.71593 Frontiers in nutrition IF: 05.100Volume 12, Issue No.213Weight loss increases circadian gene expression and emotional well-being in individuals with obesity减重可提升肥胖患者的昼夜节律基因表达和情绪健康水平DOI: 10.3389/fnut.2025.1722428 Frontiers in nutrition IF: 05.100Volume 12, Issue No.214The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review高果糖玉米糖浆对肝损伤和葡萄糖代谢的影响：一项系统综述DOI: 10.3389/fnut.2025.1724398 Frontiers in public health IF: 03.400Volume 13, Issue No.215Navigating barriers and facilitators to lifestyle changes after bariatric surgery among Emirati adolescents: a qualitative study探索阿联酋青少年减重手术后的生活方式转变：障碍与促进因素的定性研究DOI: 10.3389/fpubh.2025.1702340 Eur J Paediatr Dent IF: 02.700Volume 26, Issue 4No.216SIOI Policy on Sugar Intake: Limiting Free Sugars from Earliest Days of Life to Prevent Caries, Specific Non-Communicable Diseases, and Tumors意大利儿科牙科学会（SIOI）关于糖摄入的政策：限制生命早期及终生的游离糖以预防龋齿、特定非传染性疾病与肿瘤DOI: 10.23804/ejpd.2025.26.04.02 The Journal of asthma IF: 01.300Ahead of Print.No.217Mediterranean Diet Adherence and Its Association with Inflammatory and Oxidative Stress Biomarkers in Asthma地中海饮食依从性及其与哮喘患者炎症和氧化应激生物标志物的关联DOI: 10.1080/02770903.2025.2592243 J Health Soc Behav IF: 03.600Ahead of Print.No.218Low-Density Zoning and Health Disparities in Metro Areas低密度分区与都市区健康差异DOI: 10.1177/00221465251391834 Rom J Morphol Embryol IF: 01.500Volume 66, Issue 3No.219An exploratory study on the impact of endocrine and infectious comorbidities on reproductive outcomes after Palmer-type neosalpingostomy关于内分泌及感染性共病对Palmer型输卵管再造术后生殖结局影响的探索性研究DOI: 10.47162/RJME.66.3.10 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.220P050 Impact of weight-loss interventions on psoriasis severity: a systematic review and meta-analysis减肥干预对银屑病严重程度的影响：一项系统回顾与荟萃分析DOI: 10.1093/bjd/ljaf085.078 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.221PD01 Liver fibroscanning identifies hepatic fibrosis at an early stage in erythropoietic protoporphyria: a new analysis in 132 patients肝纤维化扫描在132例红细胞生成性原卟啉病患者中早期识别肝纤维化：一项新的分析DOI: 10.1093/bjd/ljaf085.253 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.222SG15 Unravelling the risk factors for hidradenitis suppurativa: a genetic approachSG15 揭示化脓性汗腺炎的风险因素：一项遗传学方法DOI: 10.1093/bjd/ljaf085.524 British journal of dermatology IF: 09.600Volume 193, Issue Supplement_1No.223P101 Janus kinase inhibitors in palmoplantar pustulosis: a systematic review and meta-analysis of comorbidity burden to inform a feasibility trial's design (JAKPPPOT)Janus激酶抑制剂治疗掌跖脓疱病：一项针对共病负担的系统综述与荟萃分析，为可行性试验设计提供信息 (JAKPPPOT)DOI: 10.1093/bjd/ljaf085.129 BMC infectious diseases IF: 03.000Ahead of Print.No.224Effectiveness comparison of nirmatrelvir/ritonavir versus molnupiravir in COVID-19 patients with comorbidities in Taiwan: a multi-centre electronic health record study台湾COVID-19共病症患者中奈玛特韦/利托那韦与莫诺拉韦有效性比较：一项多中心电子健康记录研究DOI: 10.1186/s12879-025-12316-0 BMC surgery IF: 01.800Ahead of Print.No.225Predictors of acute gangrenous cholecystitis and its complications: a retrospective cohort study急性坏疽性胆囊炎及其并发症的预测因素：一项回顾性队列研究DOI: 10.1186/s12893-025-03356-z BMC public health IF: 03.600Ahead of Print.No.226The relationship of the nutritional literacy level of individuals with diabetes on nutrition, quality of life, and metabolic control糖尿病患者的营养素养水平与其营养、生活质量和代谢控制的关系DOI: 10.1186/s12889-025-25948-3 BMC public health IF: 03.600Ahead of Print.No.227Promoting physical activity at Danish schools targeting youth who are not in employment, education or training (NEET): a qualitative study促进丹麦学校中针对未就业、未受教育或未接受培训（NEET）青年的体力活动：一项定性研究DOI: 10.1186/s12889-025-25879-z BMC public health IF: 03.600Ahead of Print.No.228Global prevalence of multimorbidity among people living with type 2 diabetes: a systematic review and meta-analysis全球2型糖尿病患者中多病共患的患病率：一项系统综述和荟萃分析DOI: 10.1186/s12889-025-25570-3 Annals of surgical oncology IF: 03.500Ahead of Print.No.229ASO Author Reflections: Can Targeted Nutrition Level the Playing Field? Reflections on Preoperative Support for Malnourished Colorectal Cancer Patients in ERASASO作者述评：靶向营养支持能否改善公平性？——ERAS中营养不良结直肠癌患者术前支持的反思DOI: 10.1245/s10434-025-18832-2 Nature reviews. Endocrinology IF: 40.000Ahead of Print.No.230The hidden health effects of endocrine-disrupting chemicals内分泌干扰化学物质的隐匿健康效应DOI: 10.1038/s41574-025-01222-9 Nature communications IF: 15.700Ahead of Print.No.231Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms短期热量限制期间雄性小鼠的肝脏代谢重编程涉及增强的糖皮质激素节律DOI: 10.1038/s41467-025-67228-z Nature communications IF: 15.700Ahead of Print.No.232In vivo base editing rescues ADPKD in a humanized mouse model体内碱基编辑在⼈源化⼩⿏模型中挽救ADPKDDOI: 10.1038/s41467-025-65997-1 J Cell Mol Med IF: 04.200Volume 29, Issue 23No.233Investigation of the Characteristics of Telomere Length in Koreans and Its Association With Chronic Metabolic Disorders: A Comprehensive Study韩国人端粒长度特征及其与慢性代谢性疾病关联的综合研究DOI: 10.1111/jcmm.70964 Primary care diabetes IF: 02.300Ahead of Print.No.234The U.S. diabetes belt and factors explaining the excess risk: Multifactorial modeling and machine learning analysis美国糖尿病带及其超额风险因素：多因素建模与机器学习分析DOI: 10.1016/j.pcd.2025.12.001 Clinics in shoulder and elbow IF: 01.700Ahead of Print.No.235Factors associated with shoulder function following ultrasound-guided hydrodilatation in patients with frozen shoulder: a prospective observational study冻结肩患者超声引导下液压扩张术后肩关节功能的相关因素：一项前瞻性观察研究DOI: 10.5397/cise.2025.00773 J Prev Med Public Health IF: 02.100Ahead of Print.No.236Feasibility and Preliminary Impacts of a Diabetes Education Chatbot Simulation on Glycemic Targets, Loneliness, and Health Beliefs: An Explanatory Mixed-methods Study一项解释性混合方法研究：糖尿病教育聊天机器人模拟的可行性与对血糖目标、孤独感及健康信念的初步影响DOI: 10.3961/jpmph.25.334 Epidemiology and health IF: 02.200Ahead of Print.No.237Dental implant removal rates and related factors in older adults in South Korea: a cross-sectional study using National Health Insurance Sharing Service Data韩国老年人种植牙移除率及相关因素分析：一项基于国民健康保险公团数据的横断面研究DOI: 10.4178/epih.e2025064 Epidemiology and health IF: 02.200Ahead of Print.No.238Cardiovascular Disease Risk Disparities between Immigrants and Native Koreans: A Population-Based Study in Gwangju, South Korea韩国光州的一项基于人群研究：移民与本土韩国人的心血管疾病风险差异DOI: 10.4178/epih.e2025067 Acta biomaterialia IF: 09.600Ahead of Print.No.239Engineered Cerium Oxide Nanoparticles Conjugated with Carrier Platforms: Therapeutic Mechanisms for Skin Wound Healing Applications工程化二氧化铈纳米颗粒偶联载体平台：用于皮肤伤口愈合应用的治疗机制DOI: 10.1016/j.actbio.2025.12.016 Practical radiation oncology IF: 03.500Ahead of Print.No.240Surgical Reconstruction Toxicity Following Hypofractionated Adjuvant Radiotherapy for Primary Cutaneous Melanoma原发性皮肤黑色素瘤大分割辅助放疗后的手术重建毒性研究DOI: 10.1016/j.prro.2025.11.004 Food and chemical toxicology IF: 03.500Ahead of Print.No.241Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis谷胱甘肽再合成调控对乙酰氨基酚诱导的肾毒性和肝损伤的差异效应DOI: 10.1016/j.fct.2025.115896 Experimental neurology IF: 04.200Ahead of Print.No.242Azeliragon attenuates cerebral infarction aggravation in diabetic rats: Receptor for advanced glycation end-product as a novel therapeutic target阿折拉贡减轻糖尿病大鼠脑梗死加重：晚期糖基化终末产物受体作为新型治疗靶点DOI: 10.1016/j.expneurol.2025.115588 Cell communication and signaling IF: 08.900Ahead of Print.No.243Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors磷酸化蛋白质组学揭示胰岛素和胰岛素样生长因子刺激神经元细胞的信号动态DOI: 10.1186/s12964-025-02573-6 Nature communications IF: 15.700Ahead of Print.No.244Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets儿童早期1型糖尿病中常规与调节性T细胞亚群内干细胞样与效应状态的失衡DOI: 10.1038/s41467-025-66459-4 Nature communications IF: 15.700Ahead of Print.No.2453D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes三维成像揭示人胰腺胰岛大小和内分泌组成影响其在1型糖尿病中的丢失DOI: 10.1038/s41467-025-66198-6 Nature communications IF: 15.700Ahead of Print.No.246Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth依赖胰岛素信号的DAF-16/FOXO核转位脉冲呈现全身同步化并与秀丽隐杆线虫的生长相关DOI: 10.1038/s41467-025-66164-2 Nature communications IF: 15.700Ahead of Print.No.247Proximity labeling of DAF-16 FOXO highlights aging regulatory proteinsDAF-16 FOXO的邻近标记揭示衰老调控蛋白质DOI: 10.1038/s41467-025-66409-0 Wiadomo?ci ParazytologiczneVolume 71, Issue No.248Detection of Serpentoplasma sp. (Apicomplexa: Haemohormidiidae) in dice snake (Natrix tesellata) (Colubridae: Natrix) in Azerbaijan在阿塞拜疆棋斑水蛇（Natrix tessellata）中检测到Serpentoplasma sp.（顶复门：血激素虫科）DOI: 10.17420/ap71.553 J Biol Chem IF: 03.900Ahead of Print.No.249KANK1 regulates the positioning of liprin-α1 and the spatial organisation of insulin granule fusion in pancreatic β cellsKANK1调控liprin-α1的定位及胰腺β细胞中胰岛素颗粒融合的空间组织DOI: 10.1016/j.jbc.2025.111036 Comput Biol Chem IF: 03.100Ahead of Print.No.250Apigenin potentiates glucose stimulated insulin secretion: A mechanistic insight into the mode of activation of PKA芹菜素增强葡萄糖刺激的胰岛素分泌：对蛋白激酶A激活机制的深入解析DOI: 10.1016/j.compbiolchem.2025.108796 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.251The effects of low carbohydrate and high protein diet on the anthropometric indices, blood pressure, metabolic factors, and hormones related to metabolism: A systematic review and meta-analysis低碳水化合物高蛋白饮食对人体测量学指标、血压、代谢因素及代谢相关激素影响的系统综述与荟萃分析DOI: 10.1016/j.dsx.2025.103352 Scientific reports IF: 03.900Ahead of Print.No.252Integrative severity scale for diabetic macular atrophy and ischemia using structural OCT and OCT angiography采用结构OCT和OCTA的糖尿病性黄斑萎缩与缺血的综合严重程度分级DOI: 10.1038/s41598-025-31862-w J Health Popul Nutr IF: 02.800Ahead of Print.No.253Age- and sex-specific reference values for plasma lipids and lipoproteins in thai adults: a national health examination survey analysis泰国成人血浆脂质与脂蛋白年龄-性别特异性参考值：一项全国健康调查分析DOI: 10.1186/s41043-025-01176-8 BMJ open IF: 02.300Volume 15, Issue 12No.254Associations of functional foods consumption with gastrointestinal and musculoskeletal conditions: a cross-sectional study among Bangladeshi adults功能性食品消费与胃肠道及肌肉骨骼疾病的关联性：一项孟加拉国成年人的横断面研究DOI: 10.1136/bmjopen-2025-103593 Scientific reports IF: 03.900Ahead of Print.No.255Efficacy and safety of pioglitazone versus dapagliflozin as an add-on to metformin and alogliptin combination therapy: the EPIDOTE study吡格列酮对比达格列净作为二甲双胍和阿格列汀联合治疗的添加治疗的有效性和安全性：EPIDOTE研究DOI: 10.1038/s41598-025-30882-w Updates in surgery IF: 02.200Ahead of Print.No.256Commentary on "Unappreciated, undervalued, and working in a toxic environment: the silent struggles of some surgeons"评论“不受赏识、价值被低估，并在有毒环境中工作：一些外科医生的默默挣扎”DOI: 10.1007/s13304-025-02488-4 International journal of obesity IF: 03.800Ahead of Print.No.257Preoperative 24-hour movement behaviors and early weight loss after metabolic bariatric surgery: a compositional analysis术前24小时运动行为与代谢性减重手术后早期体重减轻：一项成分分析DOI: 10.1038/s41366-025-01983-3 Surgical endoscopy IF: 02.700Ahead of Print.No.258Special findings in high-resolution manometry prior to metabolic surgery: obesity as a risk factor for esophagogastric junction outflow obstruction or achalasia?代谢手术前高分辨率测压的特殊发现：肥胖是食管胃结合部流出道梗阻或贲门失弛缓症的危险因素？DOI: 10.1007/s00464-025-12472-z Pediatric research IF: 03.100Ahead of Print.No.259Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence极早产儿在幼儿期和青春期前血清脂质/脂肪因子与肥胖/高血压的关系DOI: 10.1038/s41390-025-04578-w Nature medicine IF: 50.000Ahead of Print.No.260Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial初级保健中优先体重管理的护理流程的实施与效果：一项阶梯式楔形整群随机试验DOI: 10.1038/s41591-025-04051-5 Scientific reports IF: 03.900Volume 15, Issue 1No.261Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura阿育吠陀制剂Rasasindura的药理学与毒理学见解DOI: 10.1038/s41598-025-97062-8 J Hum Nutr Diet IF: 02.500Volume 38, Issue 6No.262The Efficacy and Safety of a Preoperative Dietitian-Led Very Low Calorie Diet Clinic for Adults With Obesity for Colorectal Cancer Surgery: A Retrospective Cohort Study营养师主导的术前极低热量饮食门诊对计划接受结直肠癌手术的肥胖成年人的有效性与安全性：一项回顾性队列研究DOI: 10.1111/jhn.70178 Am J Clin Nutr IF: 06.900Ahead of Print.No.263Dietary fats, blood lipids and atherosclerotic cardiovascular disease: time for food-based approach?膳食脂肪、血脂与动脉粥样硬化性心血管疾病：食物导向策略的时机？DOI: 10.1016/j.ajcnut.2025.11.007 Obes Res Clin Pract IF: 02.300Ahead of Print.No.264Development and early evaluation of OPTIMAP: A digitally enabled nurse-led multidisciplinary pathway for care of people with severe obesity in a Public Australian Health NetworkOPTIMAP：在澳大利亚一公共医疗网络中，为严重肥胖患者开发的数字赋能护士主导多学科护理路径及其早期评估DOI: 10.1016/j.orcp.2025.12.004 Obes Res Clin Pract IF: 02.300Ahead of Print.No.265Vitamin D, adiposity, and cardiometabolic risk: Insights from a multivariable cross-sectional study维生素D、肥胖与心脏代谢风险：来自一项多变量横断面研究的启示DOI: 10.1016/j.orcp.2025.12.005 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.266Impact of preoperative and postoperative anti-obesity medications on early postoperative body mass index reduction after sleeve gastrectomy in pediatrics袖状胃切除术前和术后使用抗肥胖药物对儿科患者早期术后体重指数减少的影响DOI: 10.1016/j.soard.2025.10.019 Expert opinion on drug discovery IF: 04.900Ahead of Print.No.267Advancing obesity treatments through innovations in the design and manufacturing of therapeutic peptides通过治疗性肽的设计与制造创新推进肥胖治疗DOI: 10.1080/17460441.2025.2601113 Pediatric obesity IF: 02.700Volume 21, Issue 1No.268Acute Exercise-Induced Energy Expenditure and Substrate Oxidation Rates Might Not Be Associated With Subsequent Appetitive Responses in Adolescents Living With Obesity急性运动诱导的能量消耗与底物氧化率可能与肥胖青少年随后的食欲反应无关DOI: 10.1111/ijpo.70073 Epidemiology and health IF: 02.200Ahead of Print.No.269The discriminatory ability of the body roundness index and body mass index for metabolic diseases in Korean adults: a comparative study身体圆度指数与身体质量指数对韩国成年人群代谢疾病的判别能力：一项比较研究DOI: 10.4178/epih.e2025069 Physiology & behavior IF: 02.500Ahead of Print.No.270The combination of physical activity and late-time-restricted eating improves eating behavior, cognitive performance and cardiovascular parameters in women living with excess body weight体力活动与晚间限时饮食相结合可改善超重女性的饮食行为、认知表现和心血管参数DOI: 10.1016/j.physbeh.2025.115200 Appetite IF: 03.800Ahead of Print.No.271No heightened temporal attentional bias towards food or overweight bodies in adolescents with obesity青少年肥胖患者对食物或超重身体不存在更强的时间性注意偏倚DOI: 10.1016/j.appet.2025.108417 Molecular metabolism IF: 06.600Ahead of Print.No.272The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling棕色脂肪组织的先天产热能力独立于交感神经信号而发育DOI: 10.1016/j.molmet.2025.102299 Brain & development IF: 01.300Ahead of Print.No.273Brain health in youth - what are we measuring? - A comprehensive review青少年脑健康——我们测量的是什么？一项全面综述DOI: 10.1016/j.braindev.2025.104491 Science of the total environment IF: 08.000Ahead of Print.No.274Ethylparaben and consumer chemicals and their associations with metabolic disorders: A multicycle analysis of Korean National Environmental Health Survey (2015-2020)乙基对羟基苯甲酸酯及消费品化学物质与代谢紊乱的关联：基于韩国国家环境健康调查（2015-2020）的多周期分析DOI: 10.1016/j.scitotenv.2025.181128 Nutrition IF: 03.000Ahead of Print.No.275Evaluation of obesity phenotypes from childhood to adolescence: Does diet quality in childhood matter? (PASE Study-Brazil)从儿童期到青少年期肥胖表型评估：儿童期饮食质量重要吗？（巴西PASE研究）DOI: 10.1016/j.nut.2025.113027 Phytomedicine IF: 08.300Ahead of Print.No.276Anti-adipogenic effect of cryptotanshinone in 3T3-L1 preadipocytes via binding to glucagon-like peptide 1 receptor and its signaling隐丹参酮通过结合胰高血糖素样肽1受体及其信号通路在3T3-L1前脂肪细胞中发挥抗脂肪生成作用DOI: 10.1016/j.phymed.2025.157666 J Trace Elem Med Biol IF: 03.300Ahead of Print.No.277Association between serum chromium and nickel levels with metabolic markers and HOMA-β in overweight and obese adults超重及肥胖成年人的血清铬、镍水平与代谢标志物及HOMA-β的关联性研究DOI: 10.1016/j.jtemb.2025.127803 Gynecologic oncology IF: 04.100Ahead of Print.No.278Associations between obesity and outcomes in pembrolizumab-treated endometrial cancer帕博利珠单抗治疗的子宫内膜癌患者中肥胖与预后之间的关联DOI: 10.1016/j.ygyno.2025.12.001 Epilepsy & behavior IF: 02.300Ahead of Print.No.279Health risk factors and polypharmacy in people with epilepsy and their association with multimorbidity: a single centre retrospective study癫痫患者的健康风险因素与多药治疗及其与共病的关联：一项单中心回顾性研究DOI: 10.1016/j.yebeh.2025.110829 Cardiovasc Diabetol Endocrinol RepVolume 11, Issue 1No.280Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus慢性高血糖与心血管功能障碍：深入探索2型糖尿病的代谢与细胞通路DOI: 10.1186/s40842-025-00247-3 BMC Cardiovascular Disorders IF: 02.300Ahead of Print.No.281Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses血浆致动脉粥样硬化指数与多种代谢状况的关联：一项关于Meta分析的伞状评价DOI: 10.1186/s12872-025-05409-w Scientific reports IF: 03.900Ahead of Print.No.282Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes2型糖尿病中血糖变异性与氧化应激及AGE积累的关联DOI: 10.1038/s41598-025-31845-x BMC Complement Med Ther IF: 03.400Ahead of Print.No.283GB5, a synergistic phytotherapy for type 2 diabetes mellitus management: an integrated polyherbal approach from phytochemical profiling to network pharmacologyGB5：一种用于管理2型糖尿病的协同植物疗法——从植物化学分析到网络药理学的综合复方草药方法DOI: 10.1186/s12906-025-05192-3 Journal of clinical apheresis IF: 02.700Volume 40, Issue 6No.284A Simplified Scoring System to Predict In-Hospital Mortality of Leukapheresis in Patients With Leukemia用于预测白血病患者白细胞分离术住院死亡率的简化评分系统DOI: 10.1002/jca.70078 Sleep & breathing IF: 02.000Volume 30, Issue 1No.285The impact of sleep disturbances in individuals with comorbid diabetes and chronic kidney disease: a systematic review睡眠障碍对合并糖尿病与慢性肾脏病个体健康影响：一项系统综述DOI: 10.1007/s11325-025-03552-4 J Infect Public Health IF: 04.000Ahead of Print.No.286The impact of sodium-glucose co-transporter 2 inhibitors on the incidence of non-tuberculous mycobacteria infection in diabetes populations钠-葡萄糖协同转运蛋白2抑制剂对糖尿病人群非结核分枝杆菌感染发生率的影响DOI: 10.1016/j.jiph.2025.103089 European journal of pediatrics IF: 02.600Volume 185, Issue 1No.287Early kidney damage in children and adolescents with primary arterial hypertension: a systematic review儿童和青少年原发性动脉高血压的早期肾脏损伤：一项系统综述DOI: 10.1007/s00431-025-06671-y 283 Diabetes Mellitus(DM) 糖尿病 127 Obesity 肥胖症 75 Insulin 胰岛素 25 Type 2 diabetes mellitus(T2DM) 2型糖尿病 16 Metformin 二甲双胍 15 Metabolic Syndrome 代谢综合征 11 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 11 Diabetic Retinopathy 糖尿病视网膜病 9 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 8 Hypoglycemic Agents 降糖药 8 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 7 Semaglutide 司美格鲁肽 7 Dapagliflozin 达格列净 6 Diabetic Foot 糖尿病足 6 Type 1 diabetes mellitus(T1DM) 1型糖尿病 5 Diabetic Neuropathies 糖尿病性神经病变 4 Liraglutide 利拉鲁肽 3 Gabapentin 加巴喷丁 3 Pregabalin 普瑞巴林 3 Empagliflozin 恩格列净 3 Diabetes Complications 糖尿病并发症 2 Canagliflozin 卡格列净 2 Sotagliflozin 索格列净 2 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Tirzepatide 替尔泊肽 2 Dulaglutide 度拉糖肽 2 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Vildagliptin 维格列汀 1 Alogliptin 阿格列汀 1 Exenatide 艾塞那肽 1 Gastrointestinal lipase inhibitor 胃肠道脂肪酶抑制剂 1 Orlistat 奥利司他 1 Diabetic acidosis 糖尿病性酸中毒 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Ertugliflozin 艾托格列净 1 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 编辑：丁克芳 审校：丁克芳