Atopic dermatitis (AD) is a common chronic inflammatory skin disorder affecting both children
and adults, characterized by intense itching, erythema, and xerosis. The pathogenesis of AD is multifactorial,
involving genetic predisposition, immune dysregulation, skin barrier dysfunction, and environmental factors.
A growing body of evidence suggests that oxidative stress plays a critical role in AD, contributing to chronic
inflammation, immune cell activation, and skin barrier disruption. Oxidative stress arises from an imbalance
between Reactive Oxygen Species (ROS) production and antioxidant defenses, leading to cellular damage and
the exacerbation of AD symptoms. Recent research has highlighted the potential of plant-derived bioactive
compounds, particularly those with antioxidant properties, to mitigate oxidative stress and provide therapeutic
benefits in AD. These compounds, including quercetin, resveratrol, curcumin, silymarin, baicalin, luteolin, and
epigallocatechin gallate, not only neutralize ROS but also exhibit anti-inflammatory, immunomodulatory, and
skin barrier-restoring effects. Natural antioxidants from plants offer a safer alternative to conventional treatments,
which may have long-term side effects. This review provides a comprehensive overview of the mechanisms
by which oxidative stress contributes to AD and examines the potential of plant-derived antioxidants in
alleviating AD symptoms. The growing interest in these compounds underscores the need for further research
to harness their full therapeutic potential in AD management.