预约演示
更新于：2026-05-22
MK-8527
更新于：2026-05-22
概要
基本信息
权益机构- |
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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关联
15
项与 MK-8527 相关的临床试验NCT07528508
A Clinical Trial to Study the Effect of a Single Dose of MK-8527 on the Pharmacokinetics of Methadone
The goal of this study is to learn about the effect of a study medicine called MK-8527 when taken with methadone. The study will also measure what happens to the methadone in a healthy person's body over time after MK-8527 is taken.
开始日期2026-05-22 |
申办/合作机构 |
NCT07071623
A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of MK-8527 Oral Once-Monthly as HIV-1 Preexposure Prophylaxis in Women
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection.
The goals of this study are to learn:
* If taking MK-8527 once a month works to prevent HIV-1 infection better than a standard (usual) pre-exposure prophylaxis (PrEP) taken once a day
* About the safety of MK-8527 and if people tolerate it
The goals of this study are to learn:
* If taking MK-8527 once a month works to prevent HIV-1 infection better than a standard (usual) pre-exposure prophylaxis (PrEP) taken once a day
* About the safety of MK-8527 and if people tolerate it
开始日期2025-11-10 |
申办/合作机构 |
NCT07025551
An Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of MK-8527 in Participants With Mild and Moderate Hepatic Impairment
The purpose of this study is to learn what happens to MK-8527 in a person's body over time (a pharmacokinetic [PK] study). Researchers will compare what happens to MK-8527 in the body when it is given to healthy participants and participants with mild and moderate hepatic (liver) impairment.
开始日期2025-09-19 |
申办/合作机构 |
100 项与 MK-8527 相关的临床结果
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100 项与 MK-8527 相关的转化医学
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100 项与 MK-8527 相关的专利（医药）
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4
项与 MK-8527 相关的文献（医药）2024-02-01·Expert opinion on investigational drugs
Islatravir: evaluation of clinical development for HIV and HBV
Article
作者: Lorson, Christian L. ; Reddy, Athreya S. ; Singh, Kamal ; Byrareddy, Siddappa N. ; Gillespie, Samuel W. ; Naqvi, S. Hasan ; Burris, Dana M.
INTRODUCTION:
Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits HIV RT through multiple mechanisms. Contrary to all approved NtRTIs, islatravir retains a 3'OH group. In vitro and clinical data show that ISL is an ultrapotent investigational drug with high tolerability.
AREAS COVERED:
The historical development of islatravir and its mechanisms of HIV and HBV inhibition and resistance are covered. Additionally, the outcomes of Phase I and Phase II clinical trials are discussed.
EXPERT OPINION:
Current first-line antiretroviral therapy, preexposure, and postexposure prophylactic interventions are highly effective in maintaining low or undetectable viral load. Despite these measures, an unusually high rate of new infections every year warrants developing novel antivirals that can suppress drug-resistant HIV and improve compliance. ISL, an NRTTI once deemed a long-acting drug, was placed on a clinical hold. The outcome of ongoing clinical trials with a reduced ISL dose will decide its future clinical application. Additionally, MK-8527, which inhibits HIV via same mechanism as that of ISL may supersede ISL. Data on ISL inhibition of HBV are scarce, and preclinical data show dramatically lower ISL efficacy against HBV than currently preferred nucleos(t)ide drugs, indicating that ISL may not be a potent anti-HBV drug.
JOURNAL OF INFECTIOUS DISEASES
Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus
Article
作者: Fillgrove, Kerry L ; Asante-Appiah, Ernest ; Grobler, Jay A ; Kapoor, Yash ; Boddicker, Melissa A ; Ngo, Winnie ; Lange, Henry S ; Maxwell, Jill W ; Fontenot, Jane A ; Diamond, Tracy L ; Villinger, Francois J ; Li, Fangbiao ; Wan, Bang-Lin ; Wang, Shubing ; Soileau, Kelly A
Abstract:
Background:
MK-8527 is a novel nucleoside reverse transcriptase translocation inhibitor being evaluated for prevention of HIV-1 acquisition. MK-8527 is phosphorylated intracellularly to its active form, MK-8527-triphosphate, which inhibits HIV-1 replication. This study evaluated the efficacy of oral MK-8527 as pre-exposure prophylaxis in rhesus macaques challenged intrarectally with simian–human immunodeficiency virus (SHIV).
Methods:
Two groups of male macaques (n = 8 per group) received weekly oral doses of MK-8527 for 12 weeks. Starting 1 week after treatment initiation, the macaques received weekly intrarectal challenge with SHIV162P3 for 10 weeks. Each group was treated in 3 dosing panels: Group 1 received MK-8527 6, 1, and 0 mg/kg (vehicle only), whereas Group 2 received MK-8527 2, 0.3, and 0.1 mg/kg. A washout period of ≥4 weeks followed each dosing panel. A control group (n = 8) was challenged without receiving MK-8527. Plasma viral loads were monitored weekly, with infection confirmed by 2 consecutive measurements of SHIV RNA >100 copies/mL. Concentrations of MK-8527 phosphorylated forms were quantified using liquid chromatography-tandem mass spectrometry.
Results:
Once-weekly doses of MK-8527 ≥ 0.1 mg/kg for 12 weeks conferred complete protection against intrarectal SHIV acquisition, and 7/8 untreated control macaques and 5/8 vehicle-only macaques became infected. The rate of infection for macaques receiving MK-8527 was at least 11.1-fold (P = .009) lower compared with the control or vehicle group. MK-8527-triphosphate trough concentrations at 0.1 mg/kg resulted in a mean inhibitory quotient of 2.2.
Conclusions:
Prophylaxis with MK-8527 completely protected macaques from SHIV infection, supporting its further clinical development for prevention of HIV-1 acquisition.
AIDS
The estimated cost of MK-8527 produced at scale for once-monthly oral HIV pre-exposure prophylaxis (PrEP) in low- and middle-income countries.
Article
作者: Cross, Samuel ; Hill, Andrew ; Levi, Jacob ; Venter, Francois
Objective(s)::
To estimate the potential generic production cost of MK-8527, a novel once-monthly oral nucleoside reverse transcriptase translocation inhibitor in development for HIV pre-exposure prophylaxis (PrEP), and to assess implications for cost-effectiveness and access in low- and middle-income countries (LMICs).
Design::
Cost estimation study using shipment-level active pharmaceutical ingredient (API) data and established cost-plus modelling methods to project scalable generic production pricing.
Methods::
The Trade Vision LLC database was searched (January 2020 to December 2025) for records of MK-8527 API exports to India. A weighted mean API cost was calculated and combined with annual dosing assumptions (11 mg/month). Standardised cost-plus components were applied, including formulation, API loss, packaging, transportation and tariffs, profit margin, and taxation. Sensitivity analyses explored variation in API pricing.
Results::
Three API shipments were identified, yielding a weighted mean API cost of $9,878/kg. Estimated generic production cost for monthly PrEP dosing was $4.49 per person-year (ppy). Sensitivity analyses produced a range of $4.46–$24.91ppy. These estimates are substantially below published PrEP cost-effectiveness thresholds of approximately $100ppy in sub-Saharan Africa and up to $200ppy in high-incidence settings.
Conclusions::
MK-8527 could be manufactured at extremely low cost, suggesting that intellectual property and licensing arrangements, rather than production feasibility, will determine equitable access in LMICs. Early voluntary licensing agreements could facilitate timely generic entry and affordable global scale-up if clinical efficacy is confirmed.
49
项与 MK-8527 相关的新闻（医药）2026-05-19
The Journal of Infectious Diseases. Volume 233 Issue 1
传染病杂志 233卷 1期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli (STEC) Without Inducing Toxin Production
用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体
Glen D Armstrong
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 1–2, https://doi.org/10.1093/infdis/jiaf036
Invited Perspective（特邀观点）
2
With All Good Intentions: How CDC Decisions Harmed Science and People
John Weiser
好心办坏事：美国疾控中心（CDC）的决策如何损害了科学和民众
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 3–5, https://doi.org/10.1093/infdis/jiaf584
Perspectives（观点）
3
Persistence Is Resistance: The Fight to End the HIV Epidemic Hangs in the Balance
坚持即抵抗：结束艾滋病流行的斗争悬而未决
Colleen F Kelley and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 6–8, https://doi.org/10.1093/infdis/jiaf389
Special Collection on Contemporary Research on Antimicrobial Resistance（抗菌药物耐药性当代研究特辑）
Call for Papers: Antimicrobial Resistance（征稿启事：抗菌药物耐药性）
4
How Pooled Procurement Can Expand Access to Novel Antibacterial Therapeutics Globally
集中采购如何在全球范围内扩大新型抗菌疗法的可及性
Jessica Swenson
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 9–15, https://doi.org/10.1093/infdis/jiaf370
5
Pharmacokinetics and Safety of Clofazimine in Women With Rifampicin-resistant Tuberculosis During Pregnancy and the Postpartum Period: Results From IMPAACT P1026s
妊娠期及产后利福平耐药结核病女性患者使用氯法齐明的药代动力学和安全性：IMPAACT P1026s研究结果
Jennifer A Hughes and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 16–26, https://doi.org/10.1093/infdis/jiaf504
6
Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage
ST3390的出现：源自CC5谱系的一种新型非色素性耐甲氧西林金黄色葡萄球菌克隆
Emily A Felton and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 27–37, https://doi.org/10.1093/infdis/jiaf410
7
Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities
建立医疗机构针对抗菌药物耐药基因和耐药菌的污水监测实用方法
Rachel S Poretsky and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 38–48, https://doi.org/10.1093/infdis/jiaf434
8
Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom
英国近期感染HIV-1人群中非整合酶INSTI耐药相关突变的现实流行率及病毒学结果
Christine Kelly and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 49–58, https://doi.org/10.1093/infdis/jiaf500
9
Detection of Carbapenem-Resistant Bacteria in Skilled Nursing Facility Wastewater
在专业护理机构废水中检测碳青霉烯类耐药细菌
Susanna Lenz and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 59–69, https://doi.org/10.1093/infdis/jiaf534
10
Investigating Azithromycin Activity Against ESBL-Producing Escherichia coli Under Physiologically Relevant Conditions
在生理相关条件下研究阿奇霉素对产超广谱β-内酰胺酶大肠杆菌的活性
Sean Jung and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 70–75, https://doi.org/10.1093/infdis/jiaf480
ID Translational Science Update（传染病转化医学更新）
11
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective
低生物量微生物组研究的规划与分析：数据分析视角
George I Austin and Tal Korem
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 76–86, https://doi.org/10.1093/infdis/jiae378
Major Articles and Brief Reports（主要论著和简短报告）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
12
Virulent Bacteriophages for Controlling Shiga Toxin–Producing Escherichia coli Without Inducing Toxin Production
用于控制产志贺毒素大肠杆菌（STEC）且不诱导毒素产生的烈性噬菌体
Eunshin Cho and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 87–95, https://doi.org/10.1093/infdis/jiaf035
13
Hygromycin A Treatment of Borrelia burgdorferi–Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic
对伯氏疏螺旋体感染的白足鼠使用潮霉素A治疗，提示其作为针对储存宿主抗生素的潜在作用
Stephanie S You and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 96–100, https://doi.org/10.1093/infdis/jiaf363
14
Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies
固有杀菌活性低，且其阳性对3期肺炎球菌疫苗成人研究无影响
Weifeng Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 101–111, https://doi.org/10.1093/infdis/jiaf427
15
Population Structure of Escherichia coli Isolated From the Human Bloodstream, Human and Animal Feces, and the Environment in Northern Tanzania
坦桑尼亚北部从人体血液、人和动物粪便以及环境中分离出的大肠杆菌的种群结构
Deng B Madut and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 112–121, https://doi.org/10.1093/infdis/jiaf437
Viral Disease Pathogenesis（病毒性疾病发病机制）
16
Evaluating the Breadth and Reliability of Influenza Vaccine Protection Indicators: A Secondary Analysis of an Animal Challenge Trial
评估流感疫苗保护指标的广度和可靠性：动物挑战试验的二次分析
Yao Lu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 122–131, https://doi.org/10.1093/infdis/jiaf331
17
Assessing the Transmissibility and Outbreak Risk of Measles in the United States, 2024–2030
评估2024 - 2030年美国麻疹的传播性和暴发风险
Subekshya Bidari and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 132–136, https://doi.org/10.1093/infdis/jiaf342
18
Coronavirus Disease 2019 Risk in Patients With Autoimmune Diseases Using Biologics or Small Molecules: A Population-Based Cohort Study
使用生物制剂或小分子药物治疗的自身免疫性疾病患者感染2019冠状病毒病的风险：一项基于人群的队列研究
Eun Mi Song and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 137–147, https://doi.org/10.1093/infdis/jiaf347
19
Leveraging Lyme Disease Surveillance to Simulate Powassan Virus Prevalence
利用莱姆病监测来模拟伯氏疏螺旋体脑炎病毒流行率
James M McCluskey and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 148–152, https://doi.org/10.1093/infdis/jiaf368
20
Human Metapneumovirus–, Respiratory Syncytial Virus–, and Influenza-Associated Pneumonia Hospitalizations in Colorado Adults Aged ≥50 Years, 2016–2023
2016 - 2023年科罗拉多州50岁及以上成年人中与人类偏肺病毒、呼吸道合胞病毒和流感相关的肺炎住院情况
Eric A F Simões and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 153–163, https://doi.org/10.1093/infdis/jiaf381
Malaria Disease Pathogenesis（疟疾发病机制）
21
Digital PCR Reveals High PvDBP1 but not PvEBP/DBP2 and PvRBP2b Copy Number in Plasmodium vivax From Duffy-Negative Individuals in Central Africa
数字PCR显示，在非洲中部杜菲血型阴性个体中，恶性疟原虫的PvDBP1拷贝数高，但PvEBP/DBP2和PvRBP2b拷贝数不高
Bernis Neneyoh Yengo and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 164–172, https://doi.org/10.1093/infdis/jiaf322
22
Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool
疟疾住院儿童中可溶性尿激酶型纤溶酶原激活物受体水平升高、器官功能障碍和死亡：作为风险分层工具的考量
Charles Ssuuna and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 173–177, https://doi.org/10.1093/infdis/jiaf327
23
Vaccine-Induced Antibodies to a C-Terminal Plasmodium falciparum Circumsporozoite Protein Epitope Associated With Protection Against Malaria Challenge
疫苗诱导产生的针对疟原虫环子孢子蛋白C端表位的抗体与对疟疾挑战的保护作用相关
DeAnna J Friedman-Klabanoff and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 178–190, https://doi.org/10.1093/infdis/jiaf391
24
Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial With Controlled Human Malaria Infection
在受控人体疟疾感染的孢子虫疟疾疫苗试验中，与中度和重度不良事件相关的细胞因子
Lauren P Jatt and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 191–196, https://doi.org/10.1093/infdis/jiaf435
Global Health（全球健康）
25
HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda
乌干达妊娠期HIV和梅毒合并感染与不良出生结局
Mehal Churiwal and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 197–205, https://doi.org/10.1093/infdis/jiaf453
26
Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania
坦桑尼亚北部斑点热群立克次体病及其他发热性疾病患者体内针对蜱唾液抗原AV422和钙网织蛋白的抗体
Ganga S Moorthy and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 206–215, https://doi.org/10.1093/infdis/jiaf506
27
Virological Tools Fail to Properly Identify “Unusual” Hepatitis C Virus Subtypes Resistant to Direct-Acting Antiviral Drugs in The Gambia
病毒学工具未能正确识别冈比亚对直接抗病毒药物耐药的“罕见”丙型肝炎病毒亚型
Erwan Vo-Quang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages 216–220, https://doi.org/10.1093/infdis/jiaf378
Major Articles and Brief Reports（主要论著和简短报告）
Public Health（公共健康）
28
A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA's Emerging Infectious Diseases Strategy
评估医疗对策先进研究、开发和监管批准机会的框架：生物医学高级研究与发展管理局（BARDA）新兴传染病战略的组成部分
Richard C White and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e1–e10, https://doi.org/10.1093/infdis/jiaf486
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
29
Prevalence of Candidate Vaccine Targets and Genomic Features of Pediatric Invasive Streptococcus Agalactiae in Japan
日本儿科侵袭性无乳链球菌候选疫苗靶点的流行率及基因组特征
Masashi Kasai and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e11–e21, https://doi.org/10.1093/infdis/jiaf491
30
Daptomycin-Loaded Nanocarriers Facilitate Synergistic Killing of Methicillin-Resistant Staphylococcus aureus via Lipid-Mediated Interactions and Targeting
载达托霉素纳米载体通过脂质介导的相互作用和靶向作用促进对耐甲氧西林金黄色葡萄球菌的协同杀伤
Jhih-Hang Jiang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e22–e33, https://doi.org/10.1093/infdis/jiaf492
31
Comparing Respiratory Illness Surveillance Case Definitions to Detect Bordetella pertussis in Children Aged <5 Years With Respiratory Illness in South Africa, 2017–2023
Kate Bishop and others
比较呼吸道疾病监测病例定义以检测2017 - 2023年南非5岁以下呼吸道疾病患儿中的百日咳博德特氏菌
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e34–e43, https://doi.org/10.1093/infdis/jiaf501
32
Insights on Recurrent and Sequential Clostridioides difficile Infections From Genomic Surveillance in Minnesota, USA, 2019–2021
2019 - 2021年美国明尼苏达州基因组监测对复发性及序贯性艰难梭菌感染的见解
Daniel Evans and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e44–e54, https://doi.org/10.1093/infdis/jiaf505
33
Single-Cell Transcriptome Profiling Reveals the Immune Dysregulation Characteristics of Mice Infected With Brucella abortus
单细胞转录组分析揭示感染牛布鲁氏菌小鼠的免疫失调特征
Guangzhi Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e55–e66, https://doi.org/10.1093/infdis/jiaf522
34
Culture and Adaptation of Pseudomonas aeruginosa During Early Infection in Children With Cystic Fibrosis
囊性纤维化患儿早期感染期间铜绿假单胞菌的培养与适应
Sumitra D Mitra and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e67–e76, https://doi.org/10.1093/infdis/jiaf527
Viral Disease Pathogenesis（病毒性疾病发病机制）
35
Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses
乌干达西南部裂谷热高度流行与快速进化的C谱系病毒相关
Barnabas Bakamutumaho and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e77–e88, https://doi.org/10.1093/infdis/jiaf417
36
Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial
根据衰弱评分比较高剂量与标准剂量流感疫苗对住院和死亡的相对有效性：DANFLU - 1随机试验的事后分析
Caroline Espersen and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e89–e98, https://doi.org/10.1093/infdis/jiaf420
37
Emergence of Two New Lineages of the Cosmopolitan Dengue Virus Serotype 2 in Yunnan, China, 2024
2024年中国云南出现两种新的全球流行性登革热病毒2型谱系
Man Li and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e99–e108, https://doi.org/10.1093/infdis/jiaf422
38
Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
神经精神性新冠长期症状女性患者脑脊液免疫细胞改变
Benjamin Orlinick and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e109–e117, https://doi.org/10.1093/infdis/jiaf468
39
The Role of Enoxaparin in Influenza Virus Infections and its Therapeutic Implications
依诺肝素在流感病毒感染中的作用及其治疗意义
Marta Bermejo-Jambrina and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e118–e131, https://doi.org/10.1093/infdis/jiaf470
40
Monkeypox Virus Shedding Despite Tecovirimat Treatment in a Cohort in Toronto, Canada
加拿大多伦多一队列中接受特考韦瑞治疗后猴痘病毒仍排出的情况
Jacklyn R Hurst and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e132–e139, https://doi.org/10.1093/infdis/jiaf471
41
Disentangling Temporal Trends of Clade Ib Monkeypox Virus Transmission in Burundi
厘清布隆迪Ib支系猴痘病毒传播的时间趋势
Shihui Jin and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e140–e144, https://doi.org/10.1093/infdis/jiaf475
42
Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies
利用地理多样性自然感染抗体剖析人乳头瘤病毒谱系特异性衣壳抗原性
Kavita Panwar and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e145–e150, https://doi.org/10.1093/infdis/jiaf502
43
Respiratory Virus Infections and Pulmonary Impairment After Allogeneic Hematopoietic Cell Transplantation
异基因造血细胞移植后呼吸道病毒感染与肺功能损害
Guang-Shing Cheng and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e151–e163, https://doi.org/10.1093/infdis/jiaf503
Antimicrobial Resistance (AMR)（抗菌药物耐药性）
44
Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers
通过对美国国际旅行者肠道细菌测序洞察全球抗菌药物耐药性动态
Sushmita Sridhar and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e164–e173, https://doi.org/10.1093/infdis/jiaf469
45
The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial
骨科肿瘤手术中疑似对围手术期预防用药耐药的手术部位感染负担：肿瘤手术预防性抗生素方案（PARITY）试验的二次分析
Sabine Kuster and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e174–e182, https://doi.org/10.1093/infdis/jiaf513
46
Foreign Combatants Wounded in Ukraine Colonized by Extensively Drug-Resistant Organisms: A Potential Source of Global Dissemination
在乌克兰受伤的外国战斗人员被广泛耐药菌定植：全球传播的潜在来源
Patrick Mc Gann and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e183–e191, https://doi.org/10.1093/infdis/jiaf538
HIV/AIDs（HIV/艾滋病）
47
Long-Acting Antiretroviral Therapy for Breastfeeding Women With HIV Experiencing Barriers to Adherence in Zimbabwe: Modeling Clinical Impact and Cost-effectiveness
针对津巴布韦存在依从性障碍的感染HIV的哺乳期妇女采用长效抗逆转录病毒疗法的临床影响和成本效益建模
Sujata E Tewari and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e192–e202, https://doi.org/10.1093/infdis/jiaf521
48
Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies
PURPOSE 1和2研究中来那卡帕韦、恩曲他滨/丙酚替诺福韦和恩曲他滨/富马酸替诺福韦二吡呋酯的耐药性分析
Stephanie Cox and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e203–e211, https://doi.org/10.1093/infdis/jiaf533
49
Resistance Analysis of Low-Level Virologic Rebound During HIV-1 Treatment With Lenacapavir and Broadly Neutralizing Antibodies Teropavimab and Zinlirvimab
使用来那卡帕韦和广谱中和抗体特罗帕维单抗及津利瑞单抗治疗HIV - 1期间低水平病毒学反弹的耐药性分析
Lisa Selzer and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e212–e220, https://doi.org/10.1093/infdis/jiaf559
50
IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV
白细胞介素 - 4与男性骨矿物质密度相关，白细胞介素 - 4耗竭可能导致感染HIV男性骨丢失
Ighovwerha Ofotokun and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e221–e229, https://doi.org/10.1093/infdis/jiaf570
Correspondence（读者来信）
51
External Validation of Pediatric Pneumonia and Bronchiolitis Risk Scores to Predict Mortality in Children Hospitalized in Kenya: A Retrospective Cohort Study
儿科肺炎和毛细支气管炎风险评分在预测肯尼亚住院儿童死亡率方面的外部验证：一项回顾性队列研究
Becky Gordon and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e230–e238, https://doi.org/10.1093/infdis/jiaf377
52
Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023
2016年和2023年澳大利亚东北部献血者中针对军团菌属抗体的血清阳性率
Juniper Lethbridge and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e239–e249, https://doi.org/10.1093/infdis/jiaf407
53
Diagnostic Performance and Kinetics of Hepatitis E Viral RNA and IgM Antibody Test Positivity in a Genotype 1 Outbreak in South Sudan
南苏丹1型基因型戊型肝炎病毒暴发期间戊型肝炎病毒RNA和IgM抗体检测阳性的诊断性能和动力学
Aybüke Koyuncu and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e250–e258, https://doi.org/10.1093/infdis/jiaf436
54
Leptospirosis Prevalence and Risk Factors Among Patients Presenting With Fever to 4 Healthcare Sites in Sub-Saharan Africa and South East Asia: An International Multisite Observational and Nested Case–Control Study
撒哈拉以南非洲和东南亚4个医疗站点发热患者中钩端螺旋体病的流行率和危险因素：一项国际多站点观察性和嵌套病例对照研究
John A Crump and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e259–e270, https://doi.org/10.1093/infdis/jiaf464
55
Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets
改良转基因小鼠模型可快速引发朊病毒病并重现慢性消耗性疾病的自然特征
Joseph P DeFranco and others
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e271–e276, https://doi.org/10.1093/infdis/jiaf529
Correction（更正）
56
Correction to: Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis
更正：单核细胞和巨噬细胞——严重急性呼吸综合征冠状病毒2的靶点：2019冠状病毒病免疫麻痹的线索
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e277, https://doi.org/10.1093/infdis/jiaf622
Editor's Note（编者按）
57
Editor's Note: Bartonella quintana Bacteremia and Overproduction of Interleukin-10: Model of Bacterial Persistence in Homeless People
编者按：五日热巴尔通体菌血症和白细胞介素 - 10过度产生：无家可归者细菌持续存在的模型
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e278, https://doi.org/10.1093/infdis/jiaf623
58
Editor's Note: Oral Ivermectin in the Treatment of Body Lice
编者按：口服伊维菌素治疗体虱
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Page e279, https://doi.org/10.1093/infdis/jiaf627
JID 2025 Reviewer Recognition（《传染病杂志》2025年审稿人认证）
59
2025 JID Reviewer Recognition List
2025年《传染病杂志》审稿人认证名单
The Journal of Infectious Diseases, Volume 233, Issue 1, 15 January 2026, Pages e280–e286, https://doi.org/10.1093/infdis/jiag015
The Journal of Infectious Diseases. Volume 233 Issue 2
传染病杂志 233卷 2期
https://academic.oup.com/jid/issue/
Editorials（社论）
1
2025 Content Collections from the IDSA Journals
2025年美国感染病学会（IDSA）期刊内容合集
Roger Bedimo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 221–222, https://doi.org/10.1093/infdis/jiag041
2
“Fostemsavir: More Than Meets the Eye”
“福替沙韦：不止于表面所见”
Siddharth Kogilwaimath and Netanya S Utay
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 223–226, https://doi.org/10.1093/infdis/jiaf462
3
On-Demand Dosing of HIV Preexposure Prophylaxis for Women: Has Their Time Finally Come?
女性按需服用艾滋病病毒暴露前预防药物：时机是否已到？
Susan P Buchbinder and Peter L Anderson
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 227–229, https://doi.org/10.1093/infdis/jiaf507
Invited Perspective（特邀观点）
4
The Changing Paradigm in Infectious Diseases—Host-Directed Medicine: Implications for the Next Generation of ID Physicians
感染性疾病领域的范式转变——宿主导向疗法：对下一代传染病医师的影响
Jatin M Vyas and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 230–234, https://doi.org/10.1093/infdis/jiaf497
Invited ID Translational Science Update（特邀传染病转化医学更新）
5
Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy
以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法
Jeffrey M Collins and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 235–243, https://doi.org/10.1093/infdis/jiaf510
6
Clinical Commentary on: Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy
关于“以色氨酸代谢为靶点，开发结核病生物标志物和宿主导向疗法”的临床评论
Joel D Ernst
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 244–246, https://doi.org/10.1093/infdis/jiaf624
Major Articles and Brief Reports（主要论著与简要报告）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
7
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV
福替沙韦可降低经治重度HIV感染者体内抗gp120 CD4诱导抗体的水平
Mehdi Benlarbi and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 247–256, https://doi.org/10.1093/infdis/jiaf461
8
Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention
优化女性按需服用富马酸替诺福韦二吡呋酯/恩曲他滨预防HIV感染的剂量
Nathan Engel and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 257–260, https://doi.org/10.1093/infdis/jiaf459
9
Cabotegravir and Rilpivirine Concentrations and HIV-1 RNA Suppression in Genital Fluids and Rectum in People with HIV on Long-Acting Intramuscular Cabotegravir Plus Rilpivirine Antiretroviral Therapy
接受长效肌肉注射卡博特韦加利匹韦林抗逆转录病毒治疗的HIV感染者生殖道分泌物和直肠中的卡博特韦和利匹韦林浓度及HIV-1 RNA抑制情况
Analuz Fernández and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 261–266, https://doi.org/10.1093/infdis/jiaf551
10
Elimination of Human Immunodeficiency Virus Reservoirs Harboring Intact Proviruses
清除携带完整前病毒的HIV储存库
Min Li and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 267–277, https://doi.org/10.1093/infdis/jiaf373
11
Vaccination Against Pathogens Targeting Cell-Derived Cryptic Antigens
针对细胞来源的隐蔽抗原的病原体疫苗接种
Emily S Clark and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 278–286, https://doi.org/10.1093/infdis/jiaf593
12
NAT2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic–Pharmacokinetic Cohort Study
泰国HIV感染者NAT2基因多态性与抗结核治疗所致肝毒性的关系：一项药物基因组学-药代动力学队列研究的见解
Napon Hiranburana and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 287–297, https://doi.org/10.1093/infdis/jiaf511
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
13
Interplay between Tetanus, Diphtheria, Acellular Pertussis Vaccination in Pregnancy and Infant Pneumococcal Vaccination in Shaping Infant Pneumococcal Vaccine Serotype Carriage
孕期接种破伤风、白喉、无细胞百日咳疫苗与婴儿接种肺炎球菌疫苗对婴儿肺炎球菌疫苗血清型携带的影响
Eline Van den Bosch and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 298–306, https://doi.org/10.1093/infdis/jiaf458
14
Role of Activin A–Mediated KAT8 Expression in Regulating Ferroptosis During Mycobacterium tuberculosis Infection
Activin A介导的KAT8表达在结核分枝杆菌感染中调节铁死亡的作用
Bijewar Ashish Satish and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 307–318, https://doi.org/10.1093/infdis/jiaf482
15
Phospholipid Transporter MlaFEDCB Regulates Klebsiella pneumoniae Virulence by Modulating Fimbriae Synthesis and Stress-adaptive Growth
磷脂转运蛋白MlaFEDCB通过调节菌毛合成和应激适应性生长来调控肺炎克雷伯菌的毒力
Xiaoyu Zhao and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 319–327, https://doi.org/10.1093/infdis/jiaf517
16
Novel KPC-2 Plasmid in a Clinical Salmonella Rissen Selected by Antibiotic Pressure
抗生素压力下临床沙门氏菌里森氏菌中新型KPC-2质粒的出现
María Aznar Fernández and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 328–333, https://doi.org/10.1093/infdis/jiaf536
Viral Disease Pathogenesis（病毒性疾病发病机制）
17
Respiratory Syncytial Virus Fusion Protein Epitope-Specific Antibodies and Neutralizing Activities Against Various Respiratory Syncytial Virus Strains
呼吸道合胞病毒融合蛋白表位特异性抗体对多种呼吸道合胞病毒株的中和活性
Hisao Okabe and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 334–341, https://doi.org/10.1093/infdis/jiaf375
18
Clinical and Environmental Surveillance of Poliovirus Type 2 Outbreak Using a Novel Specific Real-time Quantitative Polymerase Chain Reaction Assay, Israel, 2022–2023
2022-2023年以色列利用新型特异性实时定量聚合酶链反应检测法对2型脊髓灰质炎病毒疫情进行临床和环境监测
Itay Bar-Or and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 342–350, https://doi.org/10.1093/infdis/jiaf387
19
Robust COVID-19 Mortality Risk Assessment: Validation of a Two-Step Algorithm From the National COVID Cohort Collaborative
稳健的COVID-19死亡风险评估：国家COVID队列协作组织的两步算法验证
Bingnan Li and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 351–362, https://doi.org/10.1093/infdis/jiaf393
20
Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection
组蛋白去乙酰化酶6调节α-微管蛋白，抑制1型单纯疱疹病毒感染诱导的干扰素基因刺激因子/NLR家族含吡啶结构域蛋白3介导的小胶质细胞焦亡
Qiongzhen Zeng and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 363–374, https://doi.org/10.1093/infdis/jiaf404
Parasites（寄生虫）
21
Schistosome Infection is Associated With High-Risk Human Papillomavirus Persistence, Together With Altered Cervicovaginal Microbiota
血吸虫感染与高危型人乳头瘤病毒持续感染及宫颈阴道微生物群改变相关
Crispin Mukerebe and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 375–380, https://doi.org/10.1093/infdis/jiaf447
22
The Source-Sink Dynamics of Plasmodium vivax May Undermine Malaria Elimination Efforts in the Amazon: An Epidemiological and Population Genomic Study
恶性疟原虫的源-汇动态可能破坏亚马逊地区疟疾消除工作：一项流行病学和群体基因组学研究
Nathalia Rammé M de Albuquerque and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 381–390, https://doi.org/10.1093/infdis/jiaf457
23
Seasonal Variation and Interspecies Dynamics Among Plasmodium falciparum and ovale Species in Bagamoyo, Tanzania
坦桑尼亚巴加莫约地区恶性疟原虫和卵形疟原虫的季节性变化及种间动态
Kelly Carey-Ewend and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 391–400, https://doi.org/10.1093/infdis/jiaf498
24
Genome Sequencing of Leishmania tropica in Tissues of Moroccan Patients Reveals Microfocal Transmission Underlain by (Pseudo)Clonal and Sexual Reproduction
摩洛哥患者组织中利什曼原虫热带种的基因组测序揭示了（假）克隆和有性繁殖导致的微灶性传播
Othmane Daoui and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 401–410, https://doi.org/10.1093/infdis/jiaf485
25
Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis
顺性别女性服用多西环素暴露后预防药物期间的阴道毛滴虫感染情况
Fredericka Albertina Sesay and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages 411–415, https://doi.org/10.1093/infdis/jiaf519
26
A BEACON for Novel Disease Threats: Leveraging Artificial Intelligence for Informal Event-Based Outbreak Surveillance
应对新型疾病威胁的“灯塔”：利用人工智能进行非正式事件疫情监测
Nahid Bhadelia and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e287–e289, https://doi.org/10.1093/infdis/jiaf642
Major Articles and Brief Reports（主要论著与简要报告）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
27
Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women
沙眼衣原体特异性T细胞免疫反映南非青少年和年轻女性广泛暴露情况
Rubina Bunjun and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e290–e300, https://doi.org/10.1093/infdis/jiaf595
28
Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples
不育夫妇男性体内针对沙眼衣原体Pgp3和Hsp60的血清IgG1和IgG3抗体
Tiina Holster and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e301–e310, https://doi.org/10.1093/infdis/jiaf535
29
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants
公开可用的淋病奈瑟菌基因组主要代表体外衍生的非菌毛变异体
Iryna Boiko and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e311–e321, https://doi.org/10.1093/infdis/jiaf557
30
Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis
信号转导和转录激活因子1（STAT1）、STAT2和T细胞介导干扰素依赖性抗神经布鲁氏菌病的保护作用
Charles R Moley and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e322–e331, https://doi.org/10.1093/infdis/jiaf565
31
[18F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model
[18F]氟脱氧葡萄糖正电子发射断层扫描在诊断和监测大鼠急性金黄色葡萄球菌血管移植物感染中的应用
Emma Faddy and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e332–e341, https://doi.org/10.1093/infdis/jiaf594
32
Safety and Immunogenicity of a Klebsiella pneumoniae Tetravalent Bioconjugate Vaccine (Kleb4V) Administered to Healthy Adults: A First-in-Human Phase I/II Randomized and Controlled Study
健康成年人接种肺炎克雷伯菌四价生物结合疫苗（Kleb4V）的安全性和免疫原性：一项首次人体I/II期随机对照研究
C Alaimo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e342–e351, https://doi.org/10.1093/infdis/jiaf600
COVID-2019 Disease Pathogenesis（新冠肺炎发病机制）
33
Prevalence of Symptoms Associated With Long COVID Among Adolescents in the United States, Summer 2022
2022年夏季美国青少年中与新冠长期症状相关症状的流行情况
Deja L Edwards and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e352–e362, https://doi.org/10.1093/infdis/jiaf454
34
COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study
血液系统恶性肿瘤患者中COVID-19疫苗的有效性：一项全国性队列研究
Quincy Hofsink and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e363–e372, https://doi.org/10.1093/infdis/jiaf523
35
Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial
一种由第二代分子夹稳定在融合前构象的严重急性呼吸综合征冠状病毒2型刺突亚单位疫苗在18 - 55岁成年人中的安全性和免疫原性：一项随机、双盲、活性对照、I期试验
Keith J Chappell and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e373–e382, https://doi.org/10.1093/infdis/jiaf568
Viral Disease Pathogenesis（病毒性疾病发病机制）
36
Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine
接种第三剂麻腮风疫苗后腮腺炎抗体反应的持久性
Sun B Sowers and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e383–e391, https://doi.org/10.1093/infdis/jiaf520
37
Immune Responses to BK Virus in Renal Transplant Recipients Receiving Intravenous Immunoglobulin Treatment
接受静脉注射免疫球蛋白治疗的肾移植受者对BK病毒的免疫反应
Kevin D He and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e392–e403, https://doi.org/10.1093/infdis/jiaf525
38
Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma
鼻咽癌流行区和非流行区病例中EB病毒抗体反应模式
Ilona Argirion and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e404–e408, https://doi.org/10.1093/infdis/jiaf526
39
Genomic Surveillance and Antigenic Characterization of Respiratory Syncytial Virus (RSV) in Spain During the 2023-2024 Season of Nirsevimab Administration
2023 - 2024年西班牙尼塞韦单抗给药季节呼吸道合胞病毒（RSV）的基因组监测和抗原特征分析
María Iglesias-Caballero and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e409–e418, https://doi.org/10.1093/infdis/jiaf530
40
Establishment of a Cynomolgus Macaque Model for Human Adenovirus Type 55–Induced Respiratory Disease
建立食蟹猴模型用于研究人类55型腺病毒引起的呼吸道疾病
Sang Hwan Seo and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e419–e429, https://doi.org/10.1093/infdis/jiaf542
41
Adenovirus 40 and 41 Antibodies Associated With Protection From Infection in a Bangladeshi Birth Cohort
孟加拉国出生队列中与预防腺病毒40型和41型感染相关的抗体
Jennifer Hendrick and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e430–e440, https://doi.org/10.1093/infdis/jiaf558
42
Natural History of Nipah Virus in Hamsters: Strain, Route, and Sex-Associated Variability Characterized Using Large Datasets to Inform Pre-Clinical Study Design
利用大型数据集研究仓鼠中尼帕病毒的自然史：不同毒株、感染途径和性别的变异性，为临床前研究设计提供依据
Katherine A Davies and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e441–e453, https://doi.org/10.1093/infdis/jiaf549
43
Estimation of Prevention-Effective CAB-LA Concentrations Among Men Who Have Sex With Men (MSM) and Transgender Women (TGW) in HPTN 083
在HPTN 083研究中估算男男性行为者（MSM）和跨性别女性（TGW）中预防有效的长效卡博特韦浓度
Brett Hanscom and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e454–e461, https://doi.org/10.1093/infdis/jiaf561
44
Assessment of Concordant Human Papillomavirus Infection With 9-Valent Vaccine Types Across Anogenital Sites in Young Men
评估年轻男性肛门生殖器部位九价疫苗类型人乳头瘤病毒的一致感染情况
Cara J Broshkevitch and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e462–e470, https://doi.org/10.1093/infdis/jiaf564
Parasites（寄生虫）
45
From Skin to Sequence: Pan-species Detection and Speciation of Leishmania
从皮肤到序列：利什曼原虫的全物种检测与鉴定
Nicholas R Duncan and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e471–e480, https://doi.org/10.1093/infdis/jiaf345
46
A Human Monoclonal Antibody Targeting α-Gal Ameliorates Experimental Cutaneous Leishmaniasis
一种靶向α-半乳糖苷的人单克隆抗体可改善实验性皮肤利什曼病
Hyeseon Cho and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e481–e490, https://doi.org/10.1093/infdis/jiaf350
47
Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023
2023年桑给巴尔和坦桑尼亚的青蒿素部分耐药突变提示区域传播和非洲起源
Sean V Connelly and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e491–e495, https://doi.org/10.1093/infdis/jiaf431
48
A Multivalent Peptide Vaccine Against Malaria, Targeting Plasmodium Circumsporozoite Protein and Mosquito AgTRIO
一种针对疟疾的多价肽疫苗，靶向疟原虫环子孢子蛋白和蚊子AgTRIO
Yu-Min Chuang and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e496–e500, https://doi.org/10.1093/infdis/jiaf432
49
Spontaneous Clearance of Polymerase Chain Reaction–Positive Plasmodium vivax Parasitemia in Northwestern Thailand: An Epidemiological Perspective
泰国西北部聚合酶链反应阳性的恶性疟原虫血症的自发清除：流行病学视角
Pyae Linn Aung and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e501–e509, https://doi.org/10.1093/infdis/jiaf473
50
Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells
对致癌性肝吸虫四跨膜蛋白进行基因编辑，可损害寄生虫表面生物合成以及人宿主细胞对细胞外囊泡的摄取
Sujittra Chaiyadet and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e510–e520, https://doi.org/10.1093/infdis/jiaf466
Antimicrobial Resistance (AMR)（抗菌药物耐药性）
51
Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-based model
氨苄西林/舒巴坦联合头孢他啶/阿维巴坦治疗产金属β-内酰胺酶的碳青霉烯耐药鲍曼不动杆菌：基于基因组学的机制模型
Bhavatharini Arun and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e521–e533, https://doi.org/10.1093/infdis/jiaf567
52
CRISPR-Cas–associated SCCmec Variants in Methicillin-resistant Staphylococcus aureus Evade Rapid Diagnostic Detection
耐甲氧西林金黄色葡萄球菌中与CRISPR-Cas相关的SCCmec变异体可逃避快速诊断检测
Magdalena Podkowik and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e534–e540, https://doi.org/10.1093/infdis/jiaf575
53
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa
评估多药耐药铜绿假单胞菌中新型β-内酰胺/β-内酰胺酶抑制剂组合的表型和基因型敏感性检测方法
Clayton W Hall and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e541–e549, https://doi.org/10.1093/infdis/jiaf585
Fungi（真菌）
54
Adrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis
非免疫抑制患者隐球菌性脑膜炎的肾上腺皮质类固醇与颅内压升高
John E Bennett and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e550–e552, https://doi.org/10.1093/infdis/jiaf490
55
Corticosteroid Therapy and Long-Term Outcomes of Post-Infectious Inflammatory Syndrome in Non-HIV Immunosuppressed Cryptococcal Meningitis: A Multicenter Case Series
非HIV免疫抑制隐球菌性脑膜炎患者感染后炎性综合征的皮质类固醇治疗和长期预后：一项多中心病例系列研究
Yuya Ito and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e553–e560, https://doi.org/10.1093/infdis/jiaf620
56
Cerebral Venous Thrombosis in Previously Healthy Patients with Cryptococcal Meningitis
既往健康患者隐球菌性脑膜炎并发脑静脉血栓形成
Seher H Anjum and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e561–e569, https://doi.org/10.1093/infdis/jiaf653
57
The Gut as a Source of Infection for Fungal Pathogens: Increased Fecal Candida albicans Precedes Onset of Candida Late-Onset Sepsis in Very Preterm Infants
肠道作为真菌病原体感染的来源：极早产儿白色念珠菌粪便含量增加早于迟发性念珠菌脓毒症发作
Rimke R de Kroon and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e570–e581, https://doi.org/10.1093/infdis/jiaf524
Correspondence（读者来信）
58
Accurate Measurement of Viral Clearance in Early-Phase Antiviral Studies in Coronavirus Disease 2019
2019冠状病毒病早期抗病毒研究中病毒清除的准确测量
Phrutsamon Wongnak and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e582–e584, https://doi.org/10.1093/infdis/jiaf442
59
Evaluating Viral Load Sampling Schemes and Swabbing Methods for Optimal Surrogacy
评估病毒载量采样方案和拭子采集方法以实现最佳替代指标
Allyson Mateja and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e585–e586, https://doi.org/10.1093/infdis/jiaf443
60
Effect of 5FU on paracoccidioidomycosis
5-氟尿嘧啶对副球孢子菌病的影响
David A Stevens
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e587, https://doi.org/10.1093/infdis/jiaf508
61
Response to D. Stevens Letter
对D. Stevens信件的回复
Nycolas Preite
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Page e588, https://doi.org/10.1093/infdis/jiaf509
62
Evaluating Clinical Impacts of Accessory Genome Elements: Escherichia coli Type III Secretion System 2 in Escherichia coli and Beyond!
评估附属基因组元件的临床影响：大肠杆菌III型分泌系统2在大肠杆菌及其他细菌中的作用！
Abi Manesh and others
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e589–e590, https://doi.org/10.1093/infdis/jiaf515
63
Alarming Prevalence of Gonococcal Ceftriaxone Resistance in Vietnam—Role of Periodic Presumptive Antimicrobials?
越南淋球菌头孢曲松耐药性的惊人流行率——定期假定使用抗菌药物的作用？
Chris Kenyon
The Journal of Infectious Diseases, Volume 233, Issue 2, 15 February 2026, Pages e591–e592, https://doi.org/10.1093/infdis/jiaf553
The Journal of Infectious Diseases. Volume 233 Issue 3
传染病杂志 233卷 3期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Mechanistic Insights Into Increased Vulnerability to Respiratory Infections in HIV-Exposed Uninfected Infants
未感染婴儿HIV暴露对呼吸道感染易感性增加的机制研究
Cheryl Cohen and Penny Moore
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 417–419, https://doi.org/10.1093/infdis/jiaf494
Viewpoint（观点）
2
Every Body Has Value: Ending Discriminatory Restrictions on Anatomical Donations
每例身体都有其价值：终止对解剖捐赠的歧视性限制
Sara Gianella and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 420–422, https://doi.org/10.1093/infdis/jiaf413
ID Translational Science Update（传染病转化医学最新进展）
3
Syphilis Transmission: Contagion of Bodies and Words
梅毒传播：身体与言语的双重传播
Maurizio Bifulco and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 423–427, https://doi.org/10.1093/infdis/jiaf576
Major Articles and Brief Reports（主要论著与简要报告）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
4
Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants
母体炎症可能是导致HIV暴露于未感染婴儿对呼吸道合胞病毒免疫应答受损的原因
Christiana Smith and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 428–439, https://doi.org/10.1093/infdis/jiaf493
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
5
Large Reductions in Invasive Pneumococcal Disease and Related Morbidities Among Children in New Zealand After Change From PCV10 to PCV13
新西兰儿童在从PCV10换用PCV13后，侵袭性肺炎球菌病及相关发病率大幅下降
Andrew Anglemyer and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 440–444, https://doi.org/10.1093/infdis/jiaf587
6
Lack of S100A8 Impairs Lung-Protective Immunity Against Streptococcus pneumoniae
缺乏S100A8会损害针对肺炎链球菌的肺部保护性免疫
Lena Ostermann and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 445–457, https://doi.org/10.1093/infdis/jiaf647
7
Microbial Dominance in Diabetic Foot Osteomyelitis Determined With Nanopore Sequencing Techniques Predicts Positive Response to Surgical Intervention
利用纳米孔测序技术确定糖尿病足骨髓炎中的微生物优势种，可预测对手术干预的积极反应
Brian M Schmidt and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 458–464, https://doi.org/10.1093/infdis/jiaf617
8
Characteristics and Antiadhesion Activity of Chicken Single-Chain Fragment Variable Antibodies Against Helicobacter pylori Adhesin A
针对幽门螺杆菌黏附素A的鸡单链抗体片段的特性及其抗黏附活性
Yanan Gong and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 465–474, https://doi.org/10.1093/infdis/jiaf550
9
Bartonella henselae Subverts Host Cell Apoptosis by Linking Intracellular NOD2 Sensing to an AREG/EGFR Autocrine Survival Loop
汉赛巴尔通体通过将细胞内NOD2感知与AREG/EGFR自分泌生存环联系起来，破坏宿主细胞凋亡
Jun He and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 475–484, https://doi.org/10.1093/infdis/jiaf566
Viral Disease Pathogenesis（病毒性疾病发病机制）
10
Influenza-associated Excess Mortality Associated With Influenza B in Hong Kong, 2014–2023
2014 - 2023年香港地区乙型流感相关的超额死亡率
Jessica Y Wong and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 485–492, https://doi.org/10.1093/infdis/jiaf414
11
Disparate Kinetics of Viable Virus Shedding in Immunocompromised Patients: SARS-CoV-2 Versus Influenza Virus—A Prospective Real-World Cohort Study
免疫功能低下患者中存活病毒脱落动力学差异：新冠病毒与流感病毒——一项前瞻性真实世界队列研究
So Yun Lim and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 493–497, https://doi.org/10.1093/infdis/jiaf479
12
Autoantibodies Against Type I Interferons are a Prominent Feature in SARS-CoV-2 Fatal Disease and Hospitalization
针对I型干扰素的自身抗体是严重急性呼吸综合征冠状病毒2型致命性和住院治疗的显著特征
Rebeca Linhares Abreu Netto and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 498–509, https://doi.org/10.1093/infdis/jiaf514
13
Genetic Landscape of a Cohort of Children With Varicella Zoster Virus Encephalitis, Cerebellitis, and Stroke
水痘带状疱疹病毒脑炎、小脑炎和中风患儿队列的遗传学特征
Franziska Winzig and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 510–520, https://doi.org/10.1093/infdis/jiaf448
14
The Diagnostic Value of Soluble Epstein-Barr Virus BZLF1 Protein in Posttransplant Lymphoproliferative Disease Among Solid Organ and Hematopoietic Cell Transplant Recipients
可溶性爱泼斯坦-巴尔病毒BZLF1蛋白在实体器官和造血细胞移植受者移植后淋巴增殖性疾病中的诊断价值
Neval Ete Wareham and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 521–527, https://doi.org/10.1093/infdis/jiaf477
15
Noninvasive Detection of Occult yet Significant Liver Pathology in Alanine Aminotransferase–Normal Chronic Hepatitis B: A Multicenter Study
丙氨酸氨基转移酶正常的慢性乙型肝炎患者中非侵入性检测隐匿却重要的肝脏病理：一项多中心研究
Xinjie Li and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 528–540, https://doi.org/10.1093/infdis/jiaf554
16
Mesenteric Ischemia and Bacterial Translocation Precipitate the Intoxication Phase of Yellow Fever
肠系膜缺血和细菌移位促使黄热病进入中毒阶段
Mateus V Thomazella and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 541–553, https://doi.org/10.1093/infdis/jiaf483
17
Essential Role of Clathrin and Lipid Rafts in pH-dependent Entry of Chandipura Virus: Independence From Caveolin Pathway
网格蛋白和脂质筏在Chandipura病毒pH依赖性进入过程中的重要作用：独立于小窝蛋白途径
Ritudhwaj Tiwari and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 554–559, https://doi.org/10.1093/infdis/jiaf446
Fungi（真菌）
18
Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness
血培养中含有遗传多样的白色念珠菌菌株群体，这些菌株在棘白菌素耐受性和适应性方面可能存在差异
Giuseppe Fleres and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 560–572, https://doi.org/10.1093/infdis/jiaf495
19
Interferon-gamma Production Defects Characterize Immune Responses in Patients With Chronic Pulmonary Aspergillosis
干扰素-γ产生缺陷是慢性肺曲霉病患者免疫应答的特征
Nico A F Janssen and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 573–582, https://doi.org/10.1093/infdis/jiaf596
20
Tumor Necrosis Factor Receptor–Associated Factor 1 Inhibits Macrophage Killing of Sporothrix schenckii by Enhancing Expression and Activity of Inducible Nitric Oxide Synthase
肿瘤坏死因子受体相关因子1通过增强诱导型一氧化氮合酶的表达和活性，抑制巨噬细胞对申克孢子丝菌的杀伤作用
Congcong He and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 583–593, https://doi.org/10.1093/infdis/jiaf646
Global Health（全球健康）
21
Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India
印度结核病孕妇和非孕妇的利福平暴露情况
Prakruti S Rao and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 594–597, https://doi.org/10.1093/infdis/jiaf467
22
Evaluating the Impact of Unadjusted Confounding and Study Design on Estimated Pathogen-attributable Diarrhea Incidence Among Children in the MAL-ED Cohort
评估未调整混杂因素和研究设计对MAL-ED队列中儿童病原体归因腹泻发病率估计的影响
Charlotte R Doran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 598–606, https://doi.org/10.1093/infdis/jiaf531
23
Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea
全球肠道健康研究中对儿童严重志贺氏菌病的定义：志贺氏菌腹泻儿童中主要腹泻严重程度定义的比较
Olivia Lang Schultes and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages 607–617, https://doi.org/10.1093/infdis/jiaf630
Editorial（社论）
24
Evidence for Neuroinvasive Lassa Virus Infection in Pediatric Patients: Initial Findings and Implications
儿科患者神经侵袭性拉沙病毒感染的证据：初步发现及启示
Andrew P Platt and Daniel S Chertow
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e593–e595, https://doi.org/10.1093/infdis/jiaf548
Perspectives（展望）
25
The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis
免疫血栓形成在结核分枝杆菌控制和发病机制中的新兴作用
Seán Donohue and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e596–e599, https://doi.org/10.1093/infdis/jiaf415
ID Translational Science Update（传染病转化医学最新进展）
26
Whole-Exome Sequencing for the Identification of Genetic Factors Implicated in Severe Bacterial Infections: A Systematic Review
全外显子组测序用于鉴定与严重细菌感染相关的遗传因素：一项系统综述
Morgane Gélin and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e600–e610, https://doi.org/10.1093/infdis/jiag006
Major Articles and Brief Reports（主要论著与简要报告）
Viral Disease Pathogenesis（病毒性疾病发病机制）
27
Presence of Lassa Virus RNA in Cerebrospinal Fluid Indicating Neuroinvasive Lassa Fever in Pediatric Patients From Edo State, Nigeria
尼日利亚埃多州儿科患者脑脊液中存在拉沙病毒RNA，表明存在神经侵袭性拉沙热
Hannah Caroline Sophie Müller and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e611–e620, https://doi.org/10.1093/infdis/jiaf547
28
Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B
抗-HBs免疫复合物水平：乙型肝炎e抗原阴性慢性乙型肝炎患者核苷（酸）类似物停药后肝炎发作的新型标志物
S J Hume and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e621–e629, https://doi.org/10.1093/infdis/jiaf569
29
Oral Microbiome Diversity Matters on Nucleos(t)ide Analogue Cessation in Chronic Hepatitis B
慢性乙型肝炎患者核苷（酸）类似物停药时口腔微生物组多样性的重要性
Mahin Ghorbani and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e630–e640, https://doi.org/10.1093/infdis/jiaf591
30
A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults
一项评估健康成年人接种麻疹载体基孔肯雅病毒疫苗（MV-CHIK）的安全性、免疫原性和剂量的1期双盲试验
Patricia Winokur and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e641–e645, https://doi.org/10.1093/infdis/jiaf571
31
A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure-Proximal Design but Requires Far Fewer Blood Samples
免疫相关因素的检验阴性设计近似于传统的暴露近端设计，但所需血液样本数量要少得多
Dean Follmann and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e646–e650, https://doi.org/10.1093/infdis/jiaf572
32
Comparison of Healthcare Resource Utilization and Disease Outcomes in Adults Hospitalized with Human Metapneumovirus and Respiratory Syncytial Virus
人偏肺病毒和呼吸道合胞病毒感染住院成人患者的医疗资源利用情况和疾病预后比较
Emily Rayens and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e651–e661, https://doi.org/10.1093/infdis/jiaf597
33
Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13
禽流感病毒A(H5N1) D1.1基因型比B3.13基因型更适应人体鼻腔和气道类器官
Xiaojuan Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e662–e666, https://doi.org/10.1093/infdis/jiaf598
34
The Impact of Corticosteroid Therapy on Patients With West Nile Virus: A Retrospective Cohort Study
皮质类固醇治疗对西尼罗河病毒患者的影响：一项回顾性队列研究
Itamar Poran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e667–e673, https://doi.org/10.1093/infdis/jiaf601
35
Serological Survey in African Nonhuman Primate Species in Cameroon and the Democratic Republic of the Congo Reveals Low Overall Seroprevalence to Mpox Virus
对喀麦隆和刚果民主共和国非洲非人灵长类物种的血清学调查显示，猴痘病毒总体血清阳性率较低
Neraide Biai and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e674–e686, https://doi.org/10.1093/infdis/jiaf602
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
36
Manufacture of Clostridioides difficile Spores for Experimental Infection of Human Volunteers
用于人体志愿者实验性感染的艰难梭菌孢子制备
Annefleur D O Hensen and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e687–e695, https://doi.org/10.1093/infdis/jiaf612
37
Digital Anorectal Examination to Self-detect Primary Syphilis: A Prospective Cohort Study
数字肛门直肠检查用于自我检测原发性梅毒：一项前瞻性队列研究
Julien Tran and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e696–e705, https://doi.org/10.1093/infdis/jiaf628
38
Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis
泛素相关和SH3结构域含A（UBASH3A）基因启动子高甲基化与T淋巴细胞发生及早发性脓毒症易感性降低相关
Ziyi Wang and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e706–e711, https://doi.org/10.1093/infdis/jiaf636
39
Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse
小鼠肺鸟分枝杆菌感染序贯单一疗法的疗效
Ruth A Howe and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e712–e720, https://doi.org/10.1093/infdis/jiaf640
40
The Landscape and Regulatory Determinants of A-to-I RNA Editing in Escherichia coli and Pseudomonas aeruginosa Isolated From Patients With Urinary Tract and Ear Infections
从尿路感染和耳部感染患者中分离出的大肠杆菌和铜绿假单胞菌中A-to-I RNA编码的格局及调控决定因素
Eyal Elias and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e721–e730, https://doi.org/10.1093/infdis/jiaf645
Parasites（寄生虫）
41
Efficacy of Praziquantel for Treatment of Plasmodium falciparum Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial
双盲安慰剂对照随机试验评估吡喹酮治疗加蓬无症状成人恶性疟原虫感染的疗效
Johannes Mischlinger and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e731–e739, https://doi.org/10.1093/infdis/jiaf544
42
Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy
慢性疟疾与创伤性脾破裂相关，需行脾切除术
Putu A I Shanti and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e740–e744, https://doi.org/10.1093/infdis/jiaf629
43
Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens
间日疟原虫血液阶段抗原具有极高的遗传多样性和平衡选择的特征
Alison Paolo N Bareng and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e745–e755, https://doi.org/10.1093/infdis/jiaf539
44
How Duffy Blood Group (FY) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon
社区层面杜菲血型（FY）多态性和年龄如何调节间日疟风险：亚马逊地区一项基于人群的回顾性队列研究
Carlos A Prete and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e756–e765, https://doi.org/10.1093/infdis/jiaf562
45
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity
卡氏棘阿米巴滋养体和包囊新的活性检测方法可快速评估药物活性
Carrie A Flynn and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e766–e776, https://doi.org/10.1093/infdis/jiaf599
Global Health（全球健康）
46
Stunting Increases Influenza Virus Shedding Duration in Preschool/School-Aged Children
发育迟缓会增加学龄前/学龄儿童流感病毒脱落持续时间
Mia Q Zhu and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e777–e781, https://doi.org/10.1093/infdis/jiaf641
47
False-positive Malaria Rapid Diagnostic Tests are Prevalent Among Children Under 5 Years of Age in Uganda
乌干达5岁以下儿童疟疾快速诊断试验假阳性率较高
Caitlin A Cassidy and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e782–e790, https://doi.org/10.1093/infdis/jiaf604
48
Comparative Analysis of Flight Volume Effects on COVID-19 and Influenza Transmission Across Variable Control Intensities, 2019–2024
2019 - 2024年不同防控强度下航班量对新冠肺炎和流感传播影响的比较分析
Yanfang Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e791–e801, https://doi.org/10.1093/infdis/jiaf545
49
High Seropositivity to rK39 and Capture of Leishmania-Infected Sand Flies in Bihar and Jharkhand Emphasize the Need for Post-Elimination Surveillance of Visceral Leishmaniasis in India
比哈尔邦和贾坎德邦rK39血清阳性率高且捕获到感染利什曼原虫的白蛉，强调印度内脏利什曼病消除后需加强监测
Eva Iniguez and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e802–e811, https://doi.org/10.1093/infdis/jiaf543
Microbiome（微生物组）
50
The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children
肠道微生物组和丁酸盐可区分儿童艰难梭菌定植和感染
Maribeth R Nicholson and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e812–e822, https://doi.org/10.1093/infdis/jiaf631
51
Gut Microbiota Predicts the Risk of Future COVID-19 Hospitalization and Mortality: Insights From the Population-Based HELIUS Study
肠道微生物群可预测未来新冠肺炎住院和死亡风险：来自基于人群的HELIUS研究的见解
Robert F J Kullberg and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e823–e827, https://doi.org/10.1093/infdis/jiaf541
52
Douching Is Associated With Dysregulated Rectal Mucosal Immunity in Sexual Minority Men
灌洗与性少数男性直肠黏膜免疫失调相关
Courtney A Broedlow and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e828–e838, https://doi.org/10.1093/infdis/jiaf577
Correspondence（读者来信）
53
Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Pneumonia Hospitalization Among Medicare Beneficiaries Aged ≥65 in Long-Term Care
13价肺炎球菌结合疫苗对长期护理机构中≥65岁医疗保险受益人肺炎住院的预防效果
Wenwen Zhao and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Page e839, https://doi.org/10.1093/infdis/jiaf581
54
Letter to the Editor in Response to Zhao et al
致编辑的信（回应赵等人）
Lindsay Zielinski and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e840–e841, https://doi.org/10.1093/infdis/jiaf582
55
Fishborne Trematodiases in the United States: A Blind Spot in U.S. Emerging Infectious Disease Preparedness
美国鱼源性吸虫病：美国新兴传染病防范中的盲点
Nathkapach K Rattanapitoon and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e842–e843, https://doi.org/10.1093/infdis/jiaf588
56
Comment on “A Review of Aedes aegypti Control in Peru: Approaches and Lessons Learned”
对“秘鲁伊蚊控制回顾：方法与经验教训”的评论
Carmen Thompson Perea and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e844–e845, https://doi.org/10.1093/infdis/jiaf589
57
Balancing Pharmacokinetic Targets and Lymphocyte Declines with Once-Monthly Oral Islatravir for PrEP
平衡药代动力学目标和淋巴细胞减少情况，每月一次口服艾斯拉特韦用于暴露前预防
Anxin Wen
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e846–e847, https://doi.org/10.1093/infdis/jiaf618
58
Polio-Free, Not Risk-Free: Wastewater as Early Warning
无脊髓灰质炎，但并非无风险：废水作为早期预警
Francesco Branda and others
The Journal of Infectious Diseases, Volume 233, Issue 3, 15 March 2026, Pages e848–e849, https://doi.org/10.1093/infdis/jiaf643
The Journal of Infectious Diseases. Volume 233 Issue Supplement_1
传染病杂志 233卷 增刊1期
https://academic.oup.com/jid/issue/233/Supplement_1
SUPPLEMENT（增刊）
Molecular Epidemiology of β-Lactam Resistance in Gram-negative Bacteria in China
中国革兰氏阴性菌β-内酰胺酶类抗生素耐药性的分子流行病学
Supplement Articles（增补论著）
1
Aztreonam-Avibactam Resistance Due to Synergistic Interplay of ampC-Related Mutations in Carbapenem-Resistant Enterobacter spp
碳青霉烯耐药肠杆菌属中因ampC相关突变的协同作用导致的氨曲南-阿维巴坦耐药
Yang Zeng and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S1–S9, https://doi.org/10.1093/infdis/jiaf384
2
Molecular Mechanisms of β-Lactam Resistance and Its Contribution to Multidrug Resistance in Helicobacter pylori
幽门螺杆菌β-内酰胺酶类抗生素耐药的分子机制及其对多重耐药的影响
Jun Zhou and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S10–S20, https://doi.org/10.1093/infdis/jiaf385
3
Molecular Epidemiology and Persistence of Multidrug-Resistant Acinetobacter baumannii in Zhejiang, China (2015–2020): Insights Into Resistance, Virulence, and Transmission Dynamics
2015 - 2020年中国浙江地区多重耐药鲍曼不动杆菌的分子流行病学及持久性：对耐药性、毒力和传播动态的见解
Yisha Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S21–S30, https://doi.org/10.1093/infdis/jiaf425
4
Clinical Outcomes in Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Infection: A Cohort Study
高毒力碳青霉烯耐药肺炎克雷伯菌感染的临床预后：一项队列研究
Ya Hu and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S31–S37, https://doi.org/10.1093/infdis/jiaf460
5
Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications
碳青霉烯耐药肺炎克雷伯菌中因青霉素结合蛋白3修饰导致对头孢吡肟-他尼硼巴坦敏感性降低
Baofang Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S38–S46, https://doi.org/10.1093/infdis/jiaf463
6
Isolation of Lytic Bacteriophages Against Carbapenem-Resistant Klebsiella pneumoniae of Capsular Type KL64 From Water Collected at Multiple Sites Across China
从中国多个地点采集的水样中分离出针对荚膜型KL64碳青霉烯耐药肺炎克雷伯菌的溶菌性噬菌体
Juan Li and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S47–S55, https://doi.org/10.1093/infdis/jiaf607
7
Clinical and Molecular Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Teaching Hospital
中国某教学医院引起血流感染的碳青霉烯耐药肺炎克雷伯菌的临床和分子特征
Quanfeng Liao and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S56–S63, https://doi.org/10.1093/infdis/jiaf613
8
OmpK35 and OmpK36 Deficiencies Driving High-level Carbapenem Resistance in ST11 Klebsiella Pneumoniae
OmpK35和OmpK36缺失导致ST11型肺炎克雷伯菌高水平碳青霉烯耐药
Jiayuan Qin and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S64–S71, https://doi.org/10.1093/infdis/jiaf621
9
Carbapenem-Resistant Klebsiella pneumoniae of Sequence Type 11: A Scoping Review
序列型11的碳青霉烯耐药肺炎克雷伯菌：一项范围综述
Yongqiang Yang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S72–S80, https://doi.org/10.1093/infdis/jiaf635
10
Emergence of Carbapenem-Resistant Escherichia coli Coharboring blaCTX-M-199 and Penicillin-Binding Protein 3 Insertion Conferring Increased Aztreonam/Avibactam Resistance in South China
中国南方出现携带blaCTX-M-199且青霉素结合蛋白3插入导致氨曲南/阿维巴坦耐药性增强的碳青霉烯耐药大肠埃希菌
Jiong Wang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S81–S91, https://doi.org/10.1093/infdis/jiag025
11
Challenges and Strategies in Managing β-Lactam–Resistant Pseudomonas aeruginosa in China
中国应对β-内酰胺酶类抗生素耐药的铜绿假单胞菌所面临的挑战和策略
Yue Li and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S92–S103, https://doi.org/10.1093/infdis/jiag033
12
New Delhi Metallo-β-Lactamase Carbapenem-Resistant Klebsiella pneumoniae in Neonates: A Genome-Based Surveillance Study
新生儿中新德里金属β-内酰胺酶碳青霉烯耐药肺炎克雷伯菌：一项基于基因组的监测研究
Liting Liang and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S104–S112, https://doi.org/10.1093/infdis/jiag034
13
Trends of Carbapenem-Resistant Gram-negative Bacteria in China: A Surveillance Study Between 2015 and 2024
2015 - 2024年中国碳青霉烯耐药革兰氏阴性菌的趋势：一项监测研究
Yan Guo and others
The Journal of Infectious Diseases, Volume 233, Issue Supplement_1, 15 March 2026, Pages S113–S117, https://doi.org/10.1093/infdis/jiag083
The Journal of Infectious Diseases. Volume 233 Issue 4
传染病杂志 233卷 4期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
The Editors' Update: JID Continues to Evolve
社论更新：《传染病杂志》持续发展
Cornelius J (Neil) Clancy and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 619–620, https://doi.org/10.1093/infdis/jiag159
2
Protocols for Randomized Controlled Trials: Advancing Transparency in Infectious Diseases
随机对照试验方案：提高传染病研究的透明度
Jean-Jacques Parienti and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page 621, https://doi.org/10.1093/infdis/jiag134
3
Dissecting the Impact of the Gut Microbiome on HIV Reservoir Dynamics
剖析肠道微生物组对HIV储存库动态的影响
Christopher M Basting and Nichole R Klatt
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 622–624, https://doi.org/10.1093/infdis/jiaf560
Viewpoint（观点）
4
Doxycycline Post-exposure Prophylaxis and Off-target Antimicrobial Resistance: Potential Amplification Within Sexual Networks
多西环素暴露后预防用药与非靶向抗菌药物耐药性：性网络内潜在的耐药性放大
Manon Roberts and Peter Davis
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 625–627, https://doi.org/10.1093/infdis/jiaf439
5
Clearing the Air: Rethinking Airway Infection With CFTR Modulators
清除迷雾：重新思考囊性纤维化跨膜转导调节因子调节剂治疗下的气道感染
Edith T Zemanick and Ranjani Somayaji
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 628–630, https://doi.org/10.1093/infdis/jiaf625
Invited ID Translational Science Update（特邀传染病转化医学更新）
6
Microbiota, Mucus, and Modulators: Cystic Fibrosis Infection Pathogenesis in the Cystic Fibrosis Transmembrane Conductance Regulator Modulator Era
微生物群、黏液与调节剂：囊性纤维化跨膜转导调节因子调节剂时代囊性纤维化感染的发病机制
Christina S Thornton and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 631–639, https://doi.org/10.1093/infdis/jiaf626
Major Articles and Brief Reports（论著与简报）
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
7
HIV Reservoir Dynamics and Bacteriome Composition Along the Gut Axis
肠道轴上HIV储存库动态与细菌群组成
Mattia Trunfio and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 640–651, https://doi.org/10.1093/infdis/jiaf546
8
Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Models
急性和慢性人类免疫缺陷病毒感染中线粒体DNA片段动态：来自人类和非人类灵长类动物模型的见解
Jing Sun and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 652–663, https://doi.org/10.1093/infdis/jiag014
9
Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control
多祖先全基因组关联研究确定锌指基因簇中的变异体作为HIV控制的新型调节因子
Abraham Awada and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 664–673, https://doi.org/10.1093/infdis/jiag072
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
10
Respiratory Syncytial Virus–Mediated Gas6/Axl Axis Induces Hyporesponsive Macrophages to Promote Pneumococcal Proliferation in the Nasopharynx
呼吸道合胞病毒介导的Gas6/Axl轴诱导巨噬细胞低反应性以促进鼻咽部肺炎链球菌增殖
Saki Ishikawa and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 674–684, https://doi.org/10.1093/infdis/jiag004
11
Variable Staphylothrombin Activity in Staphylococcus aureus Bloodstream Infections
金黄色葡萄球菌血流感染中可变的葡萄球菌凝血酶活性
Gregory L Damhorst and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 685–695, https://doi.org/10.1093/infdis/jiag012
12
TLR4–MyD88–NF-κB Signaling in the Airway Epithelium Promotes Acinetobacter baumannii Clearance
气道上皮细胞中的TLR4-MyD88-NF-κB信号通路促进鲍曼不动杆菌的清除
Jisun Kim and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 696–705, https://doi.org/10.1093/infdis/jiag061
Viral Disease Pathogenesis（病毒性疾病发病机制）
13
Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study
先天性巨细胞病毒感染接受治疗的早产儿更昔洛韦剂量：一项前瞻性药代动力学研究结果
Edward P Acosta and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 706–713, https://doi.org/10.1093/infdis/jiaf528
14
National- and State-level SARS-CoV-2 Immunity Trends From January 2020 to December 2023: a Mathematical Modeling Analysis
2020年1月至2023年12月国家及州级SARS-CoV-2免疫趋势：一项数学建模分析
Fayette Klaassen and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 714–724, https://doi.org/10.1093/infdis/jiaf532
15
Risk- and Response-Adapted Treatment in Pediatric Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
儿童EB病毒相关噬血细胞性淋巴组织细胞增生症的风险和反应适应性治疗
Jing Miao and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 725–734, https://doi.org/10.1093/infdis/jiaf556
16
IPVS Consensus Statement on The Natural History of Cervical Human Papillomavirus Infection
国际乳头瘤病毒学会关于宫颈人乳头瘤病毒感染自然史的共识声明
Marc D Ryser and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 735–744, https://doi.org/10.1093/infdis/jiaf574
17
Long Non-Coding RNA NEAT1 Inhibits Enterovirus 71 Replication by Enhancing IFN-β Transcription Through DDX60 Signaling: Pathological Insights and Clinical Implications
长链非编码RNA NEAT1通过DDX60信号增强IFN-β转录抑制肠道病毒71型复制：病理学见解与临床意义
Dong Li and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 745–757, https://doi.org/10.1093/infdis/jiaf578
18
A Threshold in Anti–EBNA-1 Antibody Titers Distinguishes Salivary EBV Shedders From Nonshedders
抗EBNA-1抗体滴度的阈值可区分唾液EB病毒脱落者与非脱落者
João Vitor Mahler and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 758–762, https://doi.org/10.1093/infdis/jiag010
Tuberculosis（结核病）
19
Tuberculosis Disease Prevalence Among People Who Smoke Illicit Drugs: A Respondent- Driven Sampling Study in the Western Cape, South Africa
南非西开普省使用受访者驱动抽样法研究吸食非法毒品者中结核病的患病率
Samantha Malatesta and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 763–772, https://doi.org/10.1093/infdis/jiaf481
20
Childhood Tuberculosis and Risk of Frailty in Later Life: Evidence From a Nationally Representative Study in Brazil
巴西一项全国代表性研究显示儿童期结核病与晚年衰弱风险的关系
Evelyn Lepka de Lima and Márlon Juliano Romero Aliberti
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 773–776, https://doi.org/10.1093/infdis/jiaf563
21
A Monovalent SMAC Mimetic as a Potential Host-Directed Therapy for Tuberculosis
单价SMAC模拟物作为结核病潜在宿主导向疗法
Jiahong Ji and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 777–786, https://doi.org/10.1093/infdis/jiag031
22
Cerebrospinal Fluid Hypo-inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis
脑脊液低炎症反应是HIV相关结核性脑膜炎死亡的原因
Anna L Wilt and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages 787–798, https://doi.org/10.1093/infdis/jiag032
Editorial（社论）
23
Guiding Lines: Practical and Accessible Approaches for Analyzing Serological Data for Infectious Disease Surveillance
指导方针：用于传染病监测的血清学数据分析的实用且易获取的方法
Laura C Steinhardt
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e850–e852, https://doi.org/10.1093/infdis/jiag054
Perspectives（观点）
24
Commensal Bacteria: An Under-recognized Cause of Pneumonia
共生菌：一种被忽视的肺炎病因
Daniel M Musher and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e853–e856, https://doi.org/10.1093/infdis/jiag053
25
The Role of Antiviral Treatment of Influenza in Reducing Hospitalizations and Other Severe Outcomes: A Need for More Evidence
抗病毒治疗流感在减少住院和其他严重结局方面的作用：需要更多证据
Mark W Tenforde and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e857–e861, https://doi.org/10.1093/infdis/jiaf573
Major Articles and Brief Reports（论著与简报）
Special Report（专题报告）
26
Whose Line Is it Anyway? Defining Seropositivity Cutoffs for Infectious Disease Surveillance
究竟以谁为准？确定传染病监测血清阳性临界值
Michael T White and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e862–e871, https://doi.org/10.1093/infdis/jiaf537
Parasites（寄生虫）
27
Quantifying the Role of Importation on Sustained Malaria Transmission in a Low-to-Moderate Burden Region of Southwest Uganda
量化输入在维持乌干达西南部低至中度负担地区疟疾持续传播中的作用
Adrienne Epstein and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e872–e881, https://doi.org/10.1093/infdis/jiag008
28
Antibody-Dependent Neutrophil Phagocytosis of Plasmodium falciparum–Infected Erythrocytes Is Mediated by FcγRIIa
抗体依赖的中性粒细胞吞噬恶性疟原虫感染的红细胞由FcγRIIa介导
Maria Saeed and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e882–e890, https://doi.org/10.1093/infdis/jiag071
29
Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria
恶性疟原虫和间日疟原虫疟疾中CD4 T细胞反应的比较
Mayimuna Nalubega and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e891–e901, https://doi.org/10.1093/infdis/jiag115
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
30
Persistent Increased Plasmacytoid Dendritic Cells and Inflammation in People With HIV Years After Tuberculosis
结核病治愈数年后，HIV感染者体内浆细胞样树突状细胞持续增多且炎症反应持续存在
Maureen Ward and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e902–e912, https://doi.org/10.1093/infdis/jiaf499
31
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
急性HIV感染期及立即接受抗逆转录病毒治疗后出现的神经轴突损伤
Phillip Chan and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e913–e922, https://doi.org/10.1093/infdis/jiaf583
32
Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus
每周口服MK-8527进行预防可保护恒河猴免受猴-人免疫缺陷病毒的直肠攻击
Tracy L Diamond and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e923–e931, https://doi.org/10.1093/infdis/jiaf610
33
Partial Post-exposure Protection by Topical Inserts Containing Tenofovir Alafenamide Fumarate/Elvitegravir in a Macaque Model of Rectal Simian HIV (SHIV) Infection
在猕猴直肠猴免疫缺陷病毒（SHIV）感染模型中，含富马酸替诺福韦艾拉酚胺/埃维替韦的局部插入物提供部分暴露后保护
Natalia Makarova and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e932–e936, https://doi.org/10.1093/infdis/jiaf611
34
Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
人类免疫缺陷病毒相关心肌纤维化和偶发心力衰竭的蛋白质组学特征
Tess E Peterson and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e937–e947, https://doi.org/10.1093/infdis/jiag013
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
35
Treatment of Pseudomonas by Removal of Cloaking Antibodies: Is Common Polysaccharide Antigen a Factor?
通过去除伪装抗体治疗铜绿假单胞菌感染：常见多糖抗原是否是一个因素？
Joshua N Monteith and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e948–e956, https://doi.org/10.1093/infdis/jiag002
36
High Prevalence and Genotypic Diversity of Persistent Chlamydia Trachomatis Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities
南非少女和年轻女性中持续性沙眼衣原体感染的患病率高且基因型多样：两个城市的对比情况
Smritee Dabee and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e957–e962, https://doi.org/10.1093/infdis/jiag023
37
The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers
孕期接种百日咳疫苗对婴儿及其母亲体内抗百日咳毒素免疫球蛋白G抗体的结合表位和亲和力的影响
Aapo Knuutila and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e963–e972, https://doi.org/10.1093/infdis/jiag048
Tuberculosis（结核病）
38
Accuracy of the Phenotypic 1G Test to Detect Mycobacterium tuberculosis and Drug Resistance From Sputa in the US-Mexico Border
表型1G试验检测美国-墨西哥边境痰液中结核分枝杆菌及耐药性的准确性
Mia Aguirre and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e973–e980, https://doi.org/10.1093/infdis/jiaf638
39
Mycobacterium tuberculosis–Specific CFP-10/ESAT-6 CD4 and CD8 T-Cell Non-IFN-γ+ Responses Are Common in Young Kenyan Children Despite Low Reported Tuberculosis Exposure
尽管报告的结核病暴露率较低，但肯尼亚幼儿中仍普遍存在结核分枝杆菌特异性CFP-10/ESAT-6 CD4和CD8 T细胞非γ干扰素阳性反应
Sylvia M LaCourse and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e981–e989, https://doi.org/10.1093/infdis/jiag039
40
Modeling the Impact of Case Finding for Tuberculosis: The Role of Infection Dynamics
结核病病例发现的影响建模：感染动态的作用
Theresa S Ryckman and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e990–e998, https://doi.org/10.1093/infdis/jiag050
41
Population Pharmacokinetic Modeling of Standard- and High-Dose Rifampicin for Tuberculosis Preventive Therapy in the 2R2 Randomized Controlled Trial
2R2随机对照试验中用于结核病预防治疗的标准剂量和高剂量利福平的群体药代动力学建模
Fajri Gafar and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e999–e1010, https://doi.org/10.1093/infdis/jiag052
Viruses（病毒）
42
Improved Immune Response Against Influenza A Viruses With Receipt of a Recombinant Influenza Vaccine in Healthcare Personnel With Prior Low Antibody Response to Egg-Based Influenza Vaccines, Israel, 2019–2020
2019-2020年，以色列既往对基于鸡蛋的流感疫苗抗体反应低的医护人员接种重组流感疫苗后，对甲型流感病毒的免疫反应有所改善
Kelsey M Sumner and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1011–e1021, https://doi.org/10.1093/infdis/jiaf605
43
Antineuraminidase Antibody Responses in Older Adults After Consecutive Vaccinations With Enhanced Influenza Vaccines: A Randomized Controlled Trial
老年人连续接种强化流感疫苗后抗神经氨酸酶抗体反应：一项随机对照试验
Pavithra Daulagala and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1022–e1030, https://doi.org/10.1093/infdis/jiaf616
44
The Pandemic Respiratory Virus Epidemiological Surveillance Trial-A Self-swab Surveillance System for Respiratory Viruses Nested Within FluTracking
大流行性呼吸道病毒流行病学监测试验——嵌入FluTracking的呼吸道病毒自我拭子监测系统
Camille Esneau and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1031–e1039, https://doi.org/10.1093/infdis/jiaf632
45
Intracellular Ganciclovir Triphosphate Concentrations in Children With Congenital Cytomegalovirus Infection
先天性巨细胞病毒感染患儿体内更昔洛韦三磷酸的细胞内浓度
Brent Lindquist-Kleissler and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1040–e1045, https://doi.org/10.1093/infdis/jiaf633
46
Hepatitis E Virus Infection in Patients With Chronic Liver Diseases: A Latin American Multicenter Study
拉丁美洲多中心研究：慢性肝病患者中的戊型肝炎病毒感染情况
Anabella Clara Fantilli and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1046–e1055, https://doi.org/10.1093/infdis/jiaf615
47
In Vivo Risk Assessment of Yellow Fever Virus Transmission Through Breastfeeding, and Mechanistic Insights
母乳喂养传播黄热病病毒的体内风险评估及机制研究
Jeanne Pascard and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1056–e1068, https://doi.org/10.1093/infdis/jiaf637
Letters to the Editor（致编辑的信）
48
Re: Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis
回复：估算耐药结核病新治疗方案对早期传播的抑制作用
Tom A Yates and David A Barr
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1069–e1070, https://doi.org/10.1093/infdis/jiaf655
49
Reply to Yates and Barr
回复耶茨和巴尔
Ruvandhi R Nathavitharana and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1071–e1072, https://doi.org/10.1093/infdis/jiaf656
50
How “Enhanced” Are Enhanced Influenza Vaccines for Neuraminidase? Antigen Content and Baseline Immunity Revisited
强化流感疫苗对神经氨酸酶的“强化”程度如何？重新审视抗原含量和基线免疫力
Xiaowei Zhang
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1073–e1074, https://doi.org/10.1093/infdis/jiag042
51
Response to Letter to the Editor Regarding the Immunogenicity of Enhanced Influenza Vaccines in Inducing Neuraminidase Inhibition Antibodies
回复致编辑的关于“强化流感疫苗诱导神经氨酸酶抑制抗体免疫原性”的信
Pavithra Daulagala and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1075–e1076, https://doi.org/10.1093/infdis/jiag043
52
Comment on B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients
关于“B细胞亚群表征预测实体器官移植受者对SARS-CoV-2疫苗反应”的评论
Pınar Belviranlı Keskin
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1077, https://doi.org/10.1093/infdis/jiag055
53
Response to Dr Belviranli Keskin's Comments
回复贝尔维兰利·凯斯金的评论
James J Knox and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Page e1078, https://doi.org/10.1093/infdis/jiag056
54
Beyond Antibodies: Influenza Vaccine Induced T-Cell Response in Hematological Malignancy— Commentary on Insights From Hall et al
超越抗体：流感疫苗在血液系统恶性肿瘤患者中诱导的T细胞反应——对霍尔等人见解的评论
Katja M Sauer and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1079–e1080, https://doi.org/10.1093/infdis/jiag079
55
Advancing Understanding of Viral Interference: Insights From Rhinovirus–SARS-CoV-2 Cross-protection and Immunologic Perspectives
加深对病毒干扰的理解：来自鼻病毒-SARS-CoV-2交叉保护和免疫学视角的见解
Weikai Dong and others
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1081–e1082, https://doi.org/10.1093/infdis/jiag080
56
When PD-1 Meets Plaque: Making CD8 Senescence Signals Clinically Actionable in Treated HIV
当PD-1遇上斑块：使治疗后的HIV感染者中CD8细胞衰老信号具有临床可操作性
Xiaowei Zhang
The Journal of Infectious Diseases, Volume 233, Issue 4, 15 April 2026, Pages e1083–e1084, https://doi.org/10.1093/infdis/jiag081
The Journal of Infectious Diseases. Volume 233 Issue 5
传染病杂志 233卷 5期
https://academic.oup.com/jid/issue/
Editorial（社论）
1
Beyond Transplantation: Cytomegalovirus Viremia as a Therapeutic Target in Non-Cytomegalovirus Syndromes
超越移植：巨细胞病毒血症作为非巨细胞病毒综合征的治疗靶点
Ghady Haidar
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 799–801, https://doi.org/10.1093/infdis/jiaf648
2
When Time Is of the Essence: Hepatitis C Virus RNA Point-of-Care Testing in 15Minutes Becomes a Reality
当时间至关重要：15分钟内完成丙型肝炎病毒RNA即时检测成为现实
Tanya L Applegate and Jason Grebely
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 802–805, https://doi.org/10.1093/infdis/jiaf652
Trainee’s Corner（实习生专栏）
3
The Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It
被告知我没有在做科学的那一天——以及我为何对此心怀感激
Sara Gianella
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 806–808, https://doi.org/10.1093/infdis/jiaf614
JID Viewpoint（《传染病杂志》观点）
4
Restoring TB-specific Immunity in Early HIV Infection—the Dual Promise of Early Antiretroviral and TB Preventive Treatment
在HIV感染早期恢复结核特异性免疫——早期抗逆转录病毒治疗与结核预防性治疗的双重前景
Patrick K Moonan and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 809–811, https://doi.org/10.1093/infdis/jiaf518
Major Articles and Brief Reports（主要论著与简报）
Viral Disease Pathogenesis（病毒性疾病发病机制）
5
Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes
需要补充氧疗的住院成人SARS-CoV-2感染患者中的巨细胞病毒DNA血症：病毒学与临床特征及其与预后的关系
Michael Boeckh and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 812–822, https://doi.org/10.1093/infdis/jiaf649
6
Development of a Rapid Automated Point-of-Care Test for Hepatitis C Viral RNA on the DASH Rapid Polymerase Chain Reaction System
基于DASH快速聚合酶链反应系统的丙型肝炎病毒RNA快速自动化即时检测的开发
Jennifer L Reed and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 823–830, https://doi.org/10.1093/infdis/jiaf608
7
Serum Markers of Fibroinflammatory Activity PRO-C3 and CPa9-HNE Are Associated with Liver-Related Outcomes in Patients with Chronic Hepatitis C
纤维炎症活动血清标志物PRO-C3和CPa9-HNE与慢性丙型肝炎患者肝脏相关预后有关
Emilie Toft Skovgaard and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 831–839, https://doi.org/10.1093/infdis/jiaf552
8
A Rapid Assay for Hepatitis C Virus RNA Detection Using Reverse-Transcription Loop-Mediated Isothermal Amplification–Coupled CRISPR-Cas12b–Based Strategy
基于逆转录环介导等温扩增联合CRISPR-Cas12b策略的丙型肝炎病毒RNA快速检测方法
Avisha Chowdhury and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 840–847, https://doi.org/10.1093/infdis/jiaf609
9
Maternal-Fetal Letermovir Exposure In Vivo and Physiologically Based Pharmacokinetic Modeling: A Rationale for Congenital Cytomegalovirus Therapy
体内母胎来特莫韦暴露及生理药代动力学建模：先天性巨细胞病毒治疗的理论基础
Valentine Faure Bardon and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 848–857, https://doi.org/10.1093/infdis/jiaf619
10
Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems
使用两种现代递送系统进行雾化流感病毒人体激发的可行性与安全性
Nadine Rouphael and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 858–867, https://doi.org/10.1093/infdis/jiaf603
11
Rhinovirus-Associated Lower Respiratory Tract Infection in Hospitalized Adult Patients: A Retrospective Cohort Study
住院成人患者中与鼻病毒相关的下呼吸道感染：一项回顾性队列研究
Rongling Zhang and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 868–876, https://doi.org/10.1093/infdis/jiaf651
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
12
Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity
解码碳青霉烯耐药肺炎克雷伯菌的高毒力：基因组与表型分析揭示荚膜多糖是致病性的关键驱动因素
Li Xu and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 877–887, https://doi.org/10.1093/infdis/jiag075
13
Inflammatory Cytokine Profile in Pregnant Women Colonized With Group B Streptococcus Reveals IL-17a as a Potential Biomarker to Identify at-risk Newborns
B族链球菌定植孕妇的炎症细胞因子谱显示IL-17a可作为识别高危新生儿的潜在生物标志物
Narjis Amar and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 888–898, https://doi.org/10.1093/infdis/jiag092
14
Epitope-Based Multimeric Subunit Vaccine (ATOMSSUISpenta) Confers Broad Protection Against Streptococcus suis Infection
表位基多聚体亚单位疫苗（ATOMSSUISpenta）对猪链球菌感染提供广泛保护
Sun-Young Kim and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 899–911, https://doi.org/10.1093/infdis/jiag131
Parasites（寄生虫）
15
Pfs230 Domains 7–10 Encoded by DNA Vaccines Induce Potent Complement-Independent Transmission-Blocking Antibody Against Plasmodium falciparum
DNA疫苗编码的Pfs230结构域7–10可诱导强效非补体依赖性抗恶性疟原虫传播阻断抗体
Yi Cao and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 912–923, https://doi.org/10.1093/infdis/jiaf555
16
Uneven Plasmodium falciparum Transmission and Cryptic ovale Transmission From the Asymptomatic Reservoir in Bagamoyo, Tanzania
坦桑尼亚巴加莫约无症状感染库中恶性疟原虫传播不均与隐匿性卵形疟原虫传播
Jessica T Lin and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 924–933, https://doi.org/10.1093/infdis/jiaf634
17
Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress
Mzb1通过诱导内质网应激促进血吸虫病进展
Lanyue Pan and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 934–945, https://doi.org/10.1093/infdis/jiaf639
Antimicrobial Resistance (AMR)（抗生素耐药）
18
Longitudinal Trends in Pediatric Non-Salmonella Gram-Negative Enterobacterales Infections at a Tertiary Care Center in West Africa, 2005–2023
西非一家三级医疗中心2005–2023年儿童非沙门氏菌革兰阴性肠杆菌科感染的纵向趋势
Sumanth Cherukumilli and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 946–956, https://doi.org/10.1093/infdis/jiag027
19
The Effect of a 5-Day Course of Azithromycin on Streptococcus Pneumoniae Carriage and Antimicrobial Resistance Among Kenyan Children Discharged From Hospital
阿奇霉素5天疗程对出院肯尼亚儿童肺炎链球菌携带率及抗菌药物耐药性的影响
Tanya E Libby and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 957–965, https://doi.org/10.1093/infdis/jiag028
20
Comparative Analysis of High-Dose Dual Therapies in First-Line Helicobacter pylori Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study
高剂量双联方案一线幽门螺杆菌根除治疗的比较分析：一项逆概率加权多中心研究
Qingzhou Kong and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages 966–974, https://doi.org/10.1093/infdis/jiag059
Editorial（社论）
21
Implementation Does Not Occur in a Vacuum: Sustaining a Comprehensive and Global Vision for HIV Research
实施并非在真空中发生：维持全面且全球化的HIV研究愿景
Sara Gianella and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1085–e1087, https://doi.org/10.1093/infdis/jiag063
22
Uncovering the Hidden Impacts of Modern Medicine's Expanding Pharmacopeia on Clostridioides difficile Infection Risk
揭示现代医学不断扩展的药物谱对艰难梭菌感染风险的隐性影响
Alison Laufer Halpin and L Clifford McDonald
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1088–e1091, https://doi.org/10.1093/infdis/jiag011
Perspectives（观点）
23
Future Directions for NIH HIV Research: A Look Ahead to 2026
美国国立卫生研究院HIV研究的未来方向：展望2026年
Geri R Donenberg and Robert W Eisinger
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1092–e1093, https://doi.org/10.1093/infdis/jiag062
ID Translational Science Update（传染病转化医学更新）
24
Immune Responses to Phage Therapy in Humans: A Review
人体对噬菌体疗法的免疫应答：综述
Kiran Bosco and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1094–e1103, https://doi.org/10.1093/infdis/jiag096
Major Articles and Brief Reports（主要论著与简报）
Bacterial Disease Pathogenesis（细菌性疾病发病机制）
25
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study
与艰难梭菌感染风险相关的抗菌及非抗菌药物：一项全药物谱病例-队列研究
Kevin A Brown and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1104–e1114, https://doi.org/10.1093/infdis/jiag001
26
Age-Specific Concentrations and Seroprevalence of Antibodies Against Salmonella Enteritidis (O:9) and Salmonella Typhimurium (O:4,5) Across 3 Sites in Kenya
肯尼亚3个地区针对鼠伤寒沙门氏菌（O:9）和伤寒沙门氏菌（O:4,5）抗体的年龄特异性浓度与血清流行率
Esther M Muthumbi and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1115–e1123, https://doi.org/10.1093/infdis/jiag114
27
Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity
沙眼衣原体序列变异对pgp3抗原性的影响
Filomeno Coelho da Silva and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1124–e1129, https://doi.org/10.1093/infdis/jiag067
28
Increased Diversity and Introduction of Multidrug-Resistant Strains of Neisseria gonorrhoeae Following Cessation of COVID-19 Pandemic–Related Travel Restrictions: An Observational Genomic Epidemiologic Study
新冠疫情相关旅行限制解除后淋病奈瑟菌多样性增加及多重耐药菌株的引入：一项观察性基因组流行病学研究
Rosa C Coldbeck-Shackley and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1130–e1140, https://doi.org/10.1093/infdis/jiag097
29
Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity
致病性减弱的肺炎链球菌生物合成基因突变体可侵入黏膜上皮并诱导先天免疫
Caroline M Weight and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1141–e1153, https://doi.org/10.1093/infdis/jiag124
HIV/AIDs（人类免疫缺陷病毒/艾滋病）
30
Functional and Transcriptional Senescence Profiles of CD8+ T Cells Associate With the Presence of Carotid Plaques in People Living With HIV
HIV感染者中CD8+ T细胞的功能及转录衰老特征与颈动脉斑块有关
Marc J T Blaauw and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1154–e1164, https://doi.org/10.1093/infdis/jiag018
31
Estimating HIV-1 Viremic Time From Reservoir Sequence Diversity With Uncertainty Quantification
利用库序列多样性估算HIV-1病毒血症时间及不确定性量化
Edward N Kankaka and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1165–e1172, https://doi.org/10.1093/infdis/jiag020
32
Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus
人类免疫缺陷病毒感染者认知功能与脑影像学的纵向变化
James Kennedy and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1173–e1180, https://doi.org/10.1093/infdis/jiag029
Antimicrobial Resistance (AMR)（抗生素耐药）
33
Epidemiological and Molecular Surveillance of Multiresistant Citrobacter freundii Complex in a Tertiary Care Hospital: A Retrospective Cohort Study
三级医疗机构中多重耐药弗氏柠檬酸杆菌复合群的流行病学与分子监测：一项回顾性队列研究
Pérince Fonton and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1181–e1192, https://doi.org/10.1093/infdis/jiag066
34
The Influence of National Antibiotic Consumption on Neisseria Gonorrhoeae Antibiotic Resistance in Norway, 2003–2024
2003–2024年挪威全国抗生素消耗对淋病奈瑟菌耐药性的影响
Patricia Campbell
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1193–e1202, https://doi.org/10.1093/infdis/jiag076
35
Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo
医疗相关细菌感染中黏膜相关恒定T细胞功能的恢复支持碳青霉烯类药物对耐药菌疗效的体外恢复
Yiting Xue and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1203–e1214, https://doi.org/10.1093/infdis/jiag151
Parasites（寄生虫）
36
Febrile Temperature Augments Ring-stage Plasmodium falciparum Adhesion to Brain Endothelial Cells
发热温度增强环期恶性疟原虫对脑内皮细胞的黏附
Fatou Joof and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1215–e1225, https://doi.org/10.1093/infdis/jiaf474
37
Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial
6-重氮-5-氧代-L-正亮氨酸在马拉维有无疟疾成年人群中的安全性、耐受性与药代动力学：一项1期剂量递增临床试验
Brittany A Riggle and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1226–e1237, https://doi.org/10.1093/infdis/jiag121
38
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia
通过粪便DNA追踪诺氏疟原虫以监测东南亚和南亚野生猕猴中的人畜共患传播
Dhammika Leshan Wannigama and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1238–e1243, https://doi.org/10.1093/infdis/jiag128
Viruses（病毒）
39
Effectiveness of Measles-Mumps-Rubella Vaccination Among Persons Residing in a Congregate Migrant Shelter During a Measles Outbreak: An Observational Cohort Study
麻疹爆发期间聚集性移民收容所居住者麻疹-腮腺炎-风疹疫苗的有效性：一项观察性队列研究
Chelsea S Lutz and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1244–e1252, https://doi.org/10.1093/infdis/jiaf650
40
Quantifying the Impact of Switching From Rotarix to Rotavac Rotavirus Vaccine in Ghana
量化加纳从Rotarix转换为Rotavac轮状病毒疫苗的影响
Ernest O Asare and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1253–e1260, https://doi.org/10.1093/infdis/jiag003
41
Persistent T Cell Immunity Following Nipah Virus Infection: Evidence From Malaysian Survivors
尼帕病毒感染后T细胞免疫的持续存在：来自马来西亚幸存者的证据
Puteri Ainaa S Ibrahim and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1261–e1266, https://doi.org/10.1093/infdis/jiag017
42
Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice
BALB/c近交系与CD-1远交系小鼠中适应小鼠的马尔堡病毒与拉文病毒的特征研究
Katherine A Davies and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1267–e1272, https://doi.org/10.1093/infdis/jiag019
43
Cross-reactive H5N1 Neuraminidase Antibodies by Age and Influenza A Imprinting Cohorts of the Past Century: Population-Based Serosurvey, British Columbia, Canada
过去一个世纪不同年龄与甲型流感印记队列中H5N1神经氨酸酶交叉反应抗体：加拿大不列颠哥伦比亚省人群血清学调查
Danuta M Skowronski and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1273–e1284, https://doi.org/10.1093/infdis/jiag030
44
Inflammasome Activation and Oxidative Stress in SARS-CoV-2 Infection and Symptomatic Rebound
SARS-CoV-2感染及症状反弹中的炎症小体激活与氧化应激
Silvia Lucena Lage and others
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1285–e1297, https://doi.org/10.1093/infdis/jiag037
Letters to the Editor（致编辑的信）
45
Reply to Gianella: Redefining Science Together
致Gianella的回复：共同重新定义科学
Rachel A Bender Ignacio
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1298–e1299, https://doi.org/10.1093/infdis/jiaf644
46
Response to the Day I Was Told I Wasn’t Doing Science—And Why I’m Grateful for It
对《被告知我没有在做科学的那一天——以及我为何对此心怀感激》的回应
Darcy Wooten
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1300, https://doi.org/10.1093/infdis/jiag084
47
Reply to Gianella: Women in Academic Medicine Will Lead a Sea Change
致Gianella的回复：女性学者将引领学术医学的海变
Maile A Y Karris
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1301, https://doi.org/10.1093/infdis/jiag109
48
Between Two Standards: Reflections on the Double Bind From a Female Chinese Infectious Disease Physician
两种标准之间：一位中国女性传染病医生对双重束缚的反思
Nan Xu
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1302–e1303, https://doi.org/10.1093/infdis/jiag101
49
When “Logistics”Becomes Science: A Research Coordinator's Response on Team-Based Discovery
当"后勤"变成科学：一位研究协调员关于团队协作发现的回应
Cheryl Dullano
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Page e1304, https://doi.org/10.1093/infdis/jiag102
50
Pushing the Stone Uphill Together
共同推石上山
Scott L Letendre
The Journal of Infectious Diseases, Volume 233, Issue 5, 15 May 2026, Pages e1305–e1306, https://doi.org/10.1093/infdis/jiag125
2026-04-23
·医药地理
4月21日，FDA批准默沙东（Merck & Co.）每日一次口服双药疗法Idvynso（doravirine/islatravir）上市，适用于已实现病毒学抑制、抗逆转录病毒治疗方案稳定且无耐药史的HIV-1成人感染者。该疗法不仅是全球首个非整合酶抑制剂、不含替诺福韦的每日一次单片双药方案，更是一场迟来的“复出”。就在三年前，这款药的核心成分Islatravir，曾因安全性问题被“宣告出局”，如今又何拿下FDA批文？
01
剂量“做减法”赢回FDA
倘若单看Idvynso疗法获批的临床数据，似乎是一场顺理成章的胜利，但是值得深挖的是该药身后的“惊险一跃”，只因Islatravir的研发历程堪称一部小分子药物的逆袭剧本。
时间回到2021年12月，默沙东因在临床试验中发现Islatravir（每日0.75 mg）导致CD4+T细胞和总淋巴细胞（HIV患者免疫力的重要参考指标）下降，不得不暂停多项试验。默沙东甚至搁置了与吉利德合作的每周一次口服联合方案，这在当时，几乎称得上是对默沙东HIV管线的毁灭性打击。然而，默沙东并没有放弃Islatravir，经过数据复盘和建模分析，公司的科学家们确定，该药物在淋巴细胞中积累，高浓度会导致细胞凋亡，或细胞死亡，淋巴细胞减少呈现剂量依赖性。
默沙东随即展开了“剂量优化”攻坚战，将Islatravir每日剂量从0.75 mg大幅下调至0.25 mg，并启动新的III期临床试验。在一项剂量范围的研究中，0.25 mg每日一次的给药方案对总淋巴细胞和CD4+T细胞计数的影响与标准抗逆转录病毒疗法相当。两项III期试验在第48周的结果给出了强有力的答案：在MK-8591A-052试验中，Idvynso组仅1%病毒载量反弹至≥50拷贝/mL，与Biktarvy组完全持平。截至去年年底，0.25 mg剂量已在多项研究中被确认为最低有效剂量且不影响淋巴细胞水平。这一“减量不减效”的剂量优化策略，使Islatravir从“濒死分子”重新被推上审批跑道。
数据来源：Pharma ONE药物研发大数据平台-全球临床试验板块，中国医药工业信息中心
点击“阅读原文”获取更多数据
02
绕开“整合酶帝国”：Idvynso在切谁的蛋糕？
当前HIV治疗市场，整合酶抑制剂已筑起了一座难以撼动的帝国。吉利德的三药方案必妥维（比克替拉韦+恩曲他滨+丙酚替诺福韦）以143.34亿美元的销售额稳居全球处方量最大的抗艾药物，GSK旗下ViiV的双药方案多伟托（多替拉韦+拉米夫定）以35.08亿美元紧随其后，两者瓜分了全球双药疗法的半壁江山。
国内市场，根据PDB数据库显示，2025年吉利德国内全渠道销售额占42%，ViiV约占21%，整合酶抑制剂赛道几乎被外资垄断，国产创新药仅有江苏艾迪的艾诺米替片和河南真实生物的阿兹夫定片等零星突围。Idvynso的获批，开辟了一条截然不同的赛道。
数据来源：PDB药物综合数据库-国内全渠道放大板块，中国医药工业信息中心
从临床定位来看，Idvynso的差异化竞争力体现在两个维度。第一是机制替代性。随着整合酶抑制剂类药物的广泛使用，耐药性正在缓慢积累，部分患者还面临体重增加、肾功能影响等代谢负担。Idvynso作为非核苷类逆转录酶抑制剂/核苷类似物的双药组合，恰好针对这一临床痛点。相关行业分析师指出，该产品到2033年有望在七大主要市场实现约18亿美元的峰值销售额。与此同时，吉利德的Bictegravir/Lenacapavir（BIC/LEN）双药方案已进入III期临床，ViiV的广谱中和抗体Lotivibart（N6LS）联合卡博特韦也在推进每4个月注射一次的长效方案，双药赛道竞争将持续升温。
数据来源：Pharma ONE药物研发大数据平台-全球药物研发板块，中国医药工业信息中心
点击“阅读原文”获取更多数据
第二是老龄化适配。随着HIV感染者带病生存时间延长，合并症管理需求日益突出。不含替诺福韦的双药方案在长期用药安全性上具备天然优势。在国内，艾迪药业的ACC017作为首个进入III期临床的国产整合酶抑制剂创新药，同样瞄准了这一未被满足的临床需求，国产替代窗口正在打开。
不过，这并不意味着Idvynso能轻易撼动现有格局，因为必妥维的医生处方惯性极强。当然，默沙东自身也在推进Islatravir联合Ulonivirine的每周口服方案，长效化趋势下的竞争维度正在重构。Idvynso当下的战场，是在整合酶抑制剂治疗失败的“替代市场”和追求简化治疗方案的“转换市场”中精准卡位。同时，它也为国内正在追赶的国产创新药们提供了可参照的差异化路径。
03
从每日一片到每周一片的阶梯式布局
Idvynso的获批并不是默沙东在HIV领域的终点。细看其管线布局，就会发现从每日口服、每周口服、每月口服到长效注射的“阶梯式给药矩阵”正在成型，而Islatravir是该矩阵的基石。
在与吉利德的合作中，双方正在推进一项每周一次口服的Islatravir联合Lenacapavir（ISL/LEN）方案，目前已进入III期临床开发。两项III期试验的完整数据预计将于2026年上半年公布，若顺利，该产品有望在2027年上市，届时HIV治疗将从“每日服药”迈向“每周服药”，极大降低患者的服药负担和用药依从性压力。默沙东还在推进“每月口服”的HIV暴露前预防候选药物MK-8527的III期临床试验。这款尚未获批的长效PrEP口服药已引发全球177家组织的联合公开信，要求默沙东承诺将其纳入针对中低收入国家的可及性计划，由此可见MK-8527的潜在市场影响力。
从Idvynso的每日一次，到ISL/LEN的每周一次，再到MK-8527的每月一次，默沙东正沿着“给药频率递减”的阶梯稳步推进，每一步用的是同一核心分子在不同适应症、不同用药场景下的多维度延展。
Idvynso的获批只是一个开始。当默沙东的阶梯式产品矩阵全面铺开后，HIV治疗领域的竞争格局是否会迎来一场新的洗牌？
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2026-04-22
The US FDA approved Idvynso (doravirine/islatravir) for Merck, marking the first non-integrase strand transfer inhibitor (INSTI), tenofovir-free, once-daily complete two-drug regimen to reach approval for HIV-1 treatment in adults. The fixed-dose combination of 100 mg doravirine and 0.25 mg islatravir is indicated as a switch regimen for virologically suppressed adults with no history of virologic treatment failure and no known resistance substitutions associated with doravirine.
The approval covers use in adults with HIV-1 RNA below 50 copies per mL on a stable antiretroviral regimen for at least three months. Idvynso is a complete regimen; co-administration with other antiretrovirals is not recommended. The drug is contraindicated with strong CYP3A enzyme inducers and with lamivudine or emtricitabine, as co-administration may reduce islatravir-triphosphate concentrations and compromise efficacy. Severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported with doravirine-containing regimens, and one case of Drug Rash with Eosinophilia and Systemic Symptoms was observed during clinical trials.
The approval is supported by Week 48 data from two randomized, active-controlled, non-inferiority Phase III trials. Trial 052 (NCT05630755) was a double-blind study in 513 virologically suppressed adults previously receiving bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF), randomized 2:1 to switch to Idvynso or continue BIC/FTC/TAF. At Week 48, 1% of participants in each arm had HIV-1 RNA ≥50 copies/mL (treatment difference 0.9%, 95% CI: -1.9%, 2.9%), with 92% of Idvynso recipients maintaining viral suppression versus 94% on BIC/FTC/TAF. Trial 051 (NCT05631093) enrolled 551 participants switching from a range of antiretroviral regimens, including 64% on INSTI-based therapy. In this open-label study, 1% of Idvynso recipients versus 5% of those continuing baseline therapy had HIV-1 RNA ≥50 copies/mL at Week 48 (treatment difference -3.6%, 95% CI: -7.8%, -0.8%), with 96% versus 92% maintaining suppression. Safety profiles across both trials were comparable to comparator arms, with adverse events leading to discontinuation in 3% and 0.5% of Idvynso recipients in Trials 052 and 051, respectively.
The approval adds a mechanistically distinct oral option to a treatment landscape that has been shaped predominantly by INSTI-based regimens. Gilead’s Biktarvy (BIC/FTC/TAF) and ViiV Healthcare’s Dovato (dolutegravir/lamivudine) have become the reference standards for virologically suppressed adults, while ViiV’s long-acting injectable Cabenuva (cabotegravir/rilpivirine) addresses the growing demand for less frequent dosing. Idvynso enters this field as the only approved oral two-drug regimen that avoids both INSTIs and tenofovir, a profile relevant to patients managing renal impairment, bone density concerns, or INSTI-associated metabolic effects including weight gain. Islatravir’s dual mechanism — translocation inhibition and delayed chain termination — distinguishes it from conventional NRTIs, and its activity at low doses underpins the two-drug strategy. The published Phase III data supporting the approval appeared in The Lancet HIV in 2024, including a head-to-head comparison against BIC/FTC/TAF by Mills et al. and a broader switch study by Molina et al.
Islatravir’s broader role in Merck’s HIV pipeline extends beyond the approved daily formulation. The company is evaluating islatravir in combination with Gilead’s lenacapavir as a potential once-weekly oral regimen in the Phase III ISLEND-1 (NCT06630286) and ISLEND-2 (NCT06630299) trials, and in combination with the investigational NNRTI ulonivirine (MK-8507) in Phase IIb development. A separate once-monthly oral PrEP candidate, MK-8527, has entered Phase III evaluation in collaboration with the Gates Foundation, targeting HIV acquisition in women and adolescent girls in sub-Saharan Africa. These programs reflect a broader industry shift toward reducing dosing frequency while preserving or improving the tolerability profile that has defined the modern ART era.
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临床3期临床结果上市批准临床2期加速审批
100 项与 MK-8527 相关的药物交易
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| HIV感染 | 临床3期 | 美国 | 2025-07-31 | |
| HIV感染 | 临床3期 | 阿根廷 | 2025-07-31 | |
| HIV感染 | 临床3期 | 巴西 | 2025-07-31 | |
| HIV感染 | 临床3期 | 智利 | 2025-07-31 | |
| HIV感染 | 临床3期 | 哥伦比亚 | 2025-07-31 | |
| HIV感染 | 临床3期 | 多米尼加共和国 | 2025-07-31 | |
| HIV感染 | 临床3期 | 法国 | 2025-07-31 | |
| HIV感染 | 临床3期 | 危地马拉 | 2025-07-31 | |
| HIV感染 | 临床3期 | 肯尼亚 | 2025-07-31 | |
| HIV感染 | 临床3期 | 马来西亚 | 2025-07-31 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1期 | 18 | (Healthy) | 獵夢憲壓鑰襯製廠襯壓(鑰艱艱築獵觸獵鏇鹽遞) = 獵鹹衊構繭願築襯艱淵 製憲製糧觸積鹹壓製繭 (鬱壓窪窪網壓廠蓋窪積, 21.4) 更多 | - | 2026-02-17 | ||
(Moderate Renal Impairment) | 獵夢憲壓鑰襯製廠襯壓(鑰艱艱築獵觸獵鏇鹽遞) = 艱觸廠糧蓋壓憲醖製鏇 製憲製糧觸積鹹壓製繭 (鬱壓窪窪網壓廠蓋窪積, 24.6) 更多 | ||||||
临床2期 | 352 | Placebo to MK-8527 | 蓋憲憲構衊網窪醖網蓋 = 鏇鑰廠廠襯積醖鹽鹹遞 膚膚鏇衊糧繭繭廠蓋夢 (築蓋鑰衊築繭淵艱糧鑰, 簾繭獵齋齋鹽窪遞襯鏇 ~ 鹹繭積蓋餘簾壓膚繭糧) 更多 | - | 2026-01-07 | ||
临床1期 | 20 | (Panel A: MK-8527 1.0 mg) | 憲選繭淵願蓋憲艱糧膚(齋糧襯願遞餘廠鹹膚糧) = 蓋淵築齋鏇壓鹹繭蓋廠 醖網衊觸構廠壓襯願構 (衊糧積製鹹壓衊艱廠獵, 選觸鹽鏇願醖壓膚膚製 ~ 鏇範獵製觸獵築網醖選) 更多 | - | 2025-03-26 | ||
(Panel B: MK-8527 0.5 mg) | 憲選繭淵願蓋憲艱糧膚(齋糧襯願遞餘廠鹹膚糧) = 積積壓繭廠願艱蓋鬱鹹 醖網衊觸構廠壓襯願構 (衊糧積製鹹壓衊艱廠獵, 築壓鹽壓艱選鹽鹽夢壓 ~ 製衊糧餘餘糧選膚鬱蓋) 更多 | ||||||
临床1期 | 17 | (Panel A: MK-8527 10 mg) | 構窪製簾憲壓觸壓鹽廠(餘廠廠淵膚餘積顧夢遞) = 夢繭醖願遞窪觸壓製淵 築蓋繭衊襯製襯窪淵膚 (壓鹹範選觸網鏇壓築醖, 壓遞憲鑰窪構製鬱醖衊 ~ 鏇範鏇糧製構憲艱積淵) 更多 | - | 2020-09-28 | ||
(Panel B: MK-8527 3 mg) | 構窪製簾憲壓觸壓鹽廠(餘廠廠淵膚餘積顧夢遞) = 齋網醖製築鬱鑰壓糧窪 築蓋繭衊襯製襯窪淵膚 (壓鹹範選觸網鏇壓築醖, 餘艱夢製鑰膚壓鏇築遞 ~ 構衊壓廠壓衊壓顧醖鹹) 更多 |
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