A Prospective, Randomized, Open-Label, Parallel-Group Exploratory Study on the Effects of Metformin and Imeglimin on Metal Dynamics in Patients With Type 2 Diabetes (MIMET Study (Metformin and Imeglimin on Metal dynamics Trial))

开始日期2026-04-10

申办/合作机构-

CTRI/2026/03/0106556

/ Not yet recruiting临床4期IIT

Evaluation of safety and efficacy of Imeglimin versus Metformin in Chronic Kidney Disease Patients - NIL

开始日期2026-04-01

申办/合作机构-

NCT07436182

/ Not yet recruiting临床4期IIT

Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy

he goal of this clinical trial is to compare the mitochondrial redox effects of imeglimin versus metformin monotherapy in adults with newly diagnosed Type 2 diabetes mellitus who are treatment-naive. The main questions it aims to answer are:
Does imeglimin improve the fasting plasma pyruvate/lactate ratio (a validated surrogate of mitochondrial NAD⁺/NADH redox balance) to a greater extent than metformin after 12 weeks of treatment? Does imeglimin produce more favorable changes in secondary mitochondrial and glycemic biomarkers - including fasting plasma lactate, fasting plasma pyruvate, HbA1c, HOMA-IR, and lipid profile - compared to metformin?
Researchers will compare imeglimin 1000 mg twice daily to metformin up to 1000 mg twice daily to see if imeglimin produces superior improvement in mitochondrial oxidative capacity and cytoplasmic redox balance, reflected by a greater increase in the fasting plasma pyruvate/lactate ratio, without compromising glycemic efficacy or safety.
Participants will:
Take either imeglimin 1000 mg twice daily or metformin (titrated up to 1000 mg twice daily) orally for 12 weeks, as assigned by randomization Attend clinic visits at baseline (Week 0) and at Week 12 for fasting blood sample collection, including strict bedside deproteinization of pyruvate samples using ice-cold perchloric acid to ensure analytical accuracy Undergo measurement of fasting plasma pyruvate/lactate ratio, HbA1c, HOMA-IR, fasting glucose, fasting insulin, fasting plasma lactate, fasting plasma pyruvate, and full lipid profile at both visits Be monitored for adverse events and safety parameters, including renal function (eGFR), throughout the study period

开始日期2026-03-01

申办/合作机构

Mansoura University

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100 项与伊美格列明相关的专利（医药）

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项与伊美格列明相关的文献（医药）

2026-09-01·BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imeglimin enhances GLUT4-mediated glucose uptake and is more effective than metformin in 3T3-L1 adipocytes

Article

作者: Takahashi, Nobuhiko ; Ohmura, Kazumasa ; Yoshizaki, Takayuki ; Kimura, Atsushi P

Imeglimin, a novel oral antidiabetic agent derived from metformin, improves insulin secretion and sensitivity in patients with type 2 diabetes. Recent clinical clamp studies have identified adipose tissue as a potential target of imeglimin; however, its direct effects on adipocytes are unclear. In this study, differentiated 3T3-L1 adipocytes were treated with imeglimin or metformin. We then examined glucose concentration in the culture medium, glucose uptake, plasma membrane glucose transporter expression, and the effects of signaling inhibitors. Imeglimin enhanced glucose uptake in a dose-dependent manner and reduced glucose concentration in the culture medium. Imeglimin was more effective than metformin at equivalent concentrations. Imeglimin also exerted an additive effect in the presence of insulin. Plasma membrane fractionation and immunoblotting revealed that imeglimin increased cell-surface glucose transporter (GLUT) 4 expression selectively, without altering total GLUT4 protein or plasma membrane GLUT1 levels. This suggests that increased GLUT4 translocation contributes to enhanced glucose uptake. Further, pharmacological inhibition studies demonstrated that imeglimin-induced glucose uptake was unaffected by AMPK inhibition but attenuated by inhibition of phosphoinositide 3-kinase, Akt, or protein kinase C. Additionally, the PI3K inhibitor Ly294002 suppressed imeglimin-induced GLUT4 accumulation at the plasma membrane. These findings identify adipocytes as a relevant cellular target of imeglimin and support, at least in part, the involvement of PI3K-dependent GLUT4 regulation in facilitating glucose transport, which may contribute to favorable effects of imeglimin on adipose tissue glucose metabolism in vivo.

2026-09-01·BIOMEDICAL CHROMATOGRAPHY

AQbD‐Based Development and Optimization of a Stability‐Indicating RP‐HPLC Method for Imeglimin With Integration of Lean Six Sigma Principles

Article

作者: Sethy, Kamini ; Ghorpade, Samiksha ; Bhusari, Vidhya K.

ABSTRACT:

An accurate and green RP‐HPLC stability indicating method has been developed for estimation of Imeglimin with an AQbD approach. Method optimization was done based on Box–Behnken design by changing factors like mobile phase, pH, and flow rate for optimum resolution and retention time. Lean Six Sigma (DMAIC) and statistical process control techniques ensured the consistency of the method. Water–methanol in the ratio of 65:35 (v/v) adjusted to pH 4.0 was used as the mobile phase at a flow rate of 0.8 mL/min, having an approximate retention time of 3.7 min. Method validation was performed as per the ICH guidelines, and the method exhibited a high correlation coefficient ( R2 = 0.9994), low %RSD (< 2%), and good accuracy (99.45%–100.35%). LOD and LOQ were found to be 1.04 and 3.15 μg/mL, respectively. The results of forced degradation experiments showed significant degradation in the presence of alkaline, oxidative, and thermal stress conditions, whereas Imeglimin remained stable under photolytic stress conditions. HR‐MS and FTIR studies indicated that N‐dealkylation and N‐demethylation were possible degradation pathways. The greenness assessment of the developed method was carried out using AGREE, GAPI, BAGI, and CLICK indices.

2026-08-01·Journal of Cachexia Sarcopenia and Muscle

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing

Article

作者: Ye, Yangli ; Ueki, Kohjiro ; Shimizu, Yukiko ; Okamura, Tadashi ; Nomura, Ikumi ; Kobayashi, Naoki ; Qian, Diandian ; Awazawa, Motoharu

ABSTRACT:

Background:

Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first‐in‐class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle homeostasis, its effects on skeletal muscle under sarcopenia‐relevant conditions remain unclear.

Methods:

Imeglimin was administered to male C57BL/6 mice with high‐fat diet (HFD)–induced obesity for 6 weeks and to naturally aged (18 months old) male mice for 12 weeks. Skeletal muscle fibre morphology and transcriptomic profiles were analysed in fast‐ and slow‐twitch muscles. In parallel, C2C12 myotubes were exposed to palmitate with or without imeglimin, and inflammatory gene expression and reactive oxygen species (ROS) generation were assessed.

Results:

Imeglimin significantly increased the cross‐sectional area (CSA) of Type II fibres in the extensor digitorum longus (EDL) muscle of HFD‐fed mice (+66%, p < 0.01 vs. controls). Transcriptomic analyses revealed suppression of conserved molecular signatures of muscle atrophy, including activation of immediate‐early genes and inflammatory pathways (−62% to −79%, p < 0.05 vs. HFD‐fed mice). In palmitate‐treated C2C12 myotubes, imeglimin attenuated lipotoxicity‐induced inflammatory gene expression (−28% to −72%, p < 0.05 vs. controls) with reduced ROS generation, consistent with its cell‐autonomous effect on myocytes. Notably, in naturally aged mice, 12‐week imeglimin treatment preserved EDL muscle fibre size (+14%, p < 0.05 vs. controls) without altering systemic glucose tolerance, accompanied by transcriptomic changes overlapping with those observed in the HFD model (−27% to −82%, p < 0.05 vs. aged controls).

Conclusions:

Imeglimin attenuates skeletal muscle atrophy in obesity and ageing, accompanied by coordinated suppression of stress‐ and inflammation‐associated transcriptional programmes. These findings indicate that pharmacological regulation of mitochondrial stress responses influences skeletal muscle vulnerability under chronic metabolic stress and identify skeletal muscle as a previously underappreciated target of imeglimin action.

项与伊美格列明相关的新闻（医药）

2026-09-07

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法国 Innopsys 公司成立于1999年，总部位于法国的图卢兹，并设立美国芝加哥分部 20多年专注于激光共聚焦微阵列生物芯片扫描分析仪荧光检测硬件和软件的自主开发与生产作为超高分辨率微阵列生物芯片扫描分析仪的制造厂商，全球装机客户已超过600家 InnoScan 1100 0.5微米/高分辨率/三色荧光微阵列芯片扫描仪采用先进的激光共聚焦扫描光路和高灵敏度PMT检测器，进行多通道荧光检测有效降低荧光光漂白现象以及信号损失，还可有效缩短扫描时间 01 技术原理共聚焦光路实时共聚焦激光光路，保证高分辨率和高灵敏度，扫描结果更高清动态范围广动态范围可扩展至10⁶ bit，避免过度饱和或低信号假阴性 02 产品特点高灵敏度：实时共聚焦光路，极大提高灵敏度高分辨率： 0.5μm/pixel-40μm/pixel可调高信噪比：线扫描方式，图片无拼痕、无需阴影矫正，有效降低荧光的光漂白现象及信号损失高通量：可实现24片玻片自动进样激光光源：488nm(蓝)，532nm(绿)和635nm(红) 扫描通道：可实现三通道同时扫描，三个独立的PMT可同步检测扫描速度快：在1μm/pixel分辨率下，10.5min即可完成22mmX22mm芯片面积的扫描 03 应用方向寡核苷酸芯片、核酸芯片、基因芯片扫描：对基因功能分析、基因表型分析、基因突变分析等蛋白质芯片、多肽芯片、抗原抗体芯片扫描：对蛋白表达水平检测、功能蛋白筛选、蛋白质相互作用等糖芯片、多糖芯片、糖蛋白芯片扫描：进行糖功能学、糖蛋白、植物凝集素等研究小分子化合物芯片扫描：进行配体筛选、药物研发、疾病靶点筛选细胞组织芯片扫描：细胞代谢机制、信号传导机制；组织间蛋白表达差异等 04 应用案例蛋白质芯片扫描分析-牙周炎机制研究作者：北京大学口腔预防学系国家口腔临床研究中心应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，为探究枯草芽孢杆菌 R0179 是否能逆转牙龈卟啉单胞菌刺激诱导的 TLR、下游 p-NF-κB 及促炎细胞因子表达变化。 Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas GingivalisInduced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis（Inflammation，2025）蛋白质芯片扫描分析-结直肠癌靶点发现作者：南方医科大学联合广州医科大学附属肿瘤医院应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，揭示肠道微生物代谢产物4-HPA通过激活JAK2/STAT3信号通路，促进结直肠癌细胞分泌趋化因子CXCL3，从而招募免疫抑制性的多形核髓源性抑制细胞（PMN-MDSCs），抑制CD8T细胞的抗肿瘤活性，最终促进结直肠癌进展及免疫抑制微环境的形成。 Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs（J Clin Invest，2025）小分子化合物芯片扫描分析-RNA酶结合位点筛选作者：美国国家癌症研究所化学生物学实验室应用：作者使用微阵列生物芯片扫描分析仪-InnoScan 1100AL在635nm处对小分子化合物微阵列芯片进行荧光信号扫描和分析，通过研究发现了一种可以下调DHX15蛋白表达的化合物，该方法为新药研发过程中先导化合物的发现提供了一种新的研究策略。 Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex（ACS Medicinal Chemistry Letters, 2025）多糖芯片扫描分析-流感病毒感染研究作者：西北大学糖生物学与糖工程重点实验室应用：作者将羊栖菜来源岩藻多糖（硫酸化多糖）制备为寡糖芯片，孵育甲型流感病毒血凝素（HA）蛋白，荧光标记后扫描，分析多糖与病毒蛋白的结合活性。 Preparation of fucoidan oligosaccharides from Sargassum fusiforme using the “layer by layer” degradation strategy and their binding study with HA proteins of influenza A viruses（Carbohydrate Polymers， 2025）基因芯片扫描分析-SARS病毒突变体检测作者：意大利国家化学科学与技术研究所应用：作者使用微阵列生物芯片扫描分析仪-InnoScan，对核酸芯片进行荧光信号扫描和分析，对SARS病毒的突变体进行分型检测 Blastocyst euploidy rates in low-prognosis patients according to the POSEIDON criteria: a retrospective analysis of 3016 embryos（Biosensors , 2023）单细胞scWestern免疫印迹芯片扫描分析检测采用单细胞蛋白免疫印迹检测技术（scWesterns）对单细胞进行靶蛋白检测细胞芯片扫描作者：法国国家科学研究中心应用：作者使用微阵列生物芯片扫描分析仪-InnoScan，对细胞微阵列芯片进行荧光信号扫描和分析，用于制备细胞芯片方法学开发，细胞核用DRAQ5™染料（蓝色）标记，细胞质用GFP 蛋白（绿色）标记。 Dynamic inking of large-scale stamps for multiplexed microcontact printing and fabrication of cell microarrays（PLOS ONE , 2018）组织芯片扫描乳腺癌组织样本来源于Gustave Roussy Institute (France) 注：IS 1100 AL ，0.5µm/pixel 分辨率进行扫描. Panel A：绿色荧光染料标记细胞膜；红色染料标记血管 Panel B：绿色荧光染料标记细胞膜；蓝色染料标记CD45淋巴球 Panel C：2µm/pixel分辨率，扫描整张组织芯片 05 代表客户发表文献 Han, M.-M., et al., 8-Oxoguanine Modifications in Peripheral Leukocyte microRNAs Promote Age-related Inflammation by Remodeling Gene Regulatory Networks. 中国医学科学院老年医学研究所蛋白芯片 Li, J., et al., Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury. 郑州大学第一附属医院蛋白芯片 Zhao, Z., et al., Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling. 河北医科大学第二医院蛋白芯片 Li, Z., et al., Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab. 中国医学科学院北京协和医院蛋白芯片 Bi, Y., et al., Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. Cell Metabolism. 中国科学院生物物理研究所蛋白芯片 Liao, Q., et al., Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs. 南方医科大学基础医学院蛋白芯片 Hu, W., et al., Identification and Validation of Key Amino Acids in IgE Linear Epitopes of β-Lactoglobulin: Comparison of Recognition Patterns of Chinese Bovine Milk-Allergic Sera with Different Symptoms. 南昌大学蛋白芯片 Zhang, X., et al., A machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response. 兰州大学蛋白芯片 Liu, Y., et al., Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors. 西北大学多糖芯片 Better, J., et al., Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages. 德国吉森尤斯图斯 - 李比希大学核酸芯片 Sidharthan, V., et al., Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P 美国国家癌症研究所小分子化合物芯片 Tsuno, T., et al., Imeglimin suppresses glucagon secretion and induces a loss of alpha cell identity.群马大学分子与细胞调控研究所单细胞免疫印迹芯片 Foncy, J., et al., Dynamic inking of large-scale stamps for multiplexed microcontact printing and fabrication of cell microarrays. 法国图卢兹大学细胞芯片环亚产品环亚生物科技有限公司（APG BIO Ltd）成立于2011年，专注于引进国外创新技术和高品质仪器设备。返回搜狐，查看更多

寡核苷酸临床申请

2026-09-07

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InnoScan 710 IR 近红外荧光/低背景/高信噪比/覆膜/微阵列芯片扫描仪/细胞因子/炎症因子检测——覆膜芯片扫描金标准，670/785nm 激光光源

法国 Innopsys 公司成立于1999年，总部位于法国的图卢兹，并设立美国芝加哥分部 20多年专注于激光共聚焦微阵列生物芯片扫描分析仪荧光检测硬件和软件的自主开发与生产作为超高分辨率微阵列生物芯片扫描分析仪的制造厂商，全球装机客户已超过600家 InnoScan 710 IR 近红外荧光/低背景/高信噪比/覆膜/微阵列芯片扫描仪采用先进的激光共聚焦扫描光路和高灵敏度PMT检测器，进行双通道近红外荧光检测有效降低荧光光漂白现象以及信号损失，还可有效缩短扫描时间覆膜芯片可见光波段扫描背景高，信噪比低覆膜芯片 IS-710IR红外波段785nm扫描低背景，高信噪比技术原理共聚焦光路实时共聚焦激光光路，保证高分辨率和高灵敏度，扫描结果更高清动态范围广动态范围可扩展至10⁶ bit，避免过度饱和或低信号假阴性产品特点高灵敏度：实时共聚焦光路，极大提高灵敏度高分辨率： 3μm/pixel-40μm/pixel可调高信噪比：线扫描方式，图片无拼痕、无需阴影矫正，有效降低荧光的光漂白现象及信号损失高通量：可实现24片玻片自动进样双色激光光源：670nm(绿)和785nm(红)双色扫描通道：可实现双色通道同时扫描，两个独立的PMT可同步检测扫描速度快：在10μm/pixel分辨率下，3.55min即可完成一张芯片扫描应用方向寡核苷酸芯片、核酸芯片、基因芯片扫描：对基因功能分析、基因表型分析、基因突变分析等蛋白质芯片、多肽芯片、抗原抗体芯片扫描：对蛋白表达水平检测、功能蛋白筛选、蛋白质相互作用等糖芯片、多糖芯片、糖蛋白芯片扫描：进行糖功能学、糖蛋白、植物凝集素等研究小分子化合物芯片扫描：进行配体筛选、药物研发、疾病靶点筛选细胞组织芯片扫描：细胞代谢机制、信号传导机制；组织间蛋白表达差异等应用案例蛋白质芯片扫描分析-牙周炎机制研究作者：北京大学口腔预防学系国家口腔临床研究中心应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，为探究枯草芽孢杆菌 R0179 是否能逆转牙龈卟啉单胞菌刺激诱导的 TLR、下游 p-NF-κB 及促炎细胞因子表达变化。 Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas GingivalisInduced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis（Inflammation，2025）蛋白质芯片扫描分析-结直肠癌靶点发现作者：南方医科大学联合广州医科大学附属肿瘤医院应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，揭示肠道微生物代谢产物4-HPA通过激活JAK2/STAT3信号通路，促进结直肠癌细胞分泌趋化因子CXCL3，从而招募免疫抑制性的多形核髓源性抑制细胞（PMN-MDSCs），抑制CD8T细胞的抗肿瘤活性，最终促进结直肠癌进展及免疫抑制微环境的形成。 Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs（J Clin Invest，2025）小分子化合物芯片扫描分析-RNA酶结合位点筛选作者：美国国家癌症研究所化学生物学实验室应用：作者使用微阵列生物芯片扫描分析仪-InnoScan 1100AL在635nm处对小分子化合物微阵列芯片进行荧光信号扫描和分析，通过研究发现了一种可以下调DHX15蛋白表达的化合物，该方法为新药研发过程中先导化合物的发现提供了一种新的研究策略。 Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex（ACS Medicinal Chemistry Letters, 2025）多糖芯片扫描分析-流感病毒感染研究作者：西北大学糖生物学与糖工程重点实验室应用：作者将羊栖菜来源岩藻多糖（硫酸化多糖）制备为寡糖芯片，孵育甲型流感病毒血凝素（HA）蛋白，荧光标记后扫描，分析多糖与病毒蛋白的结合活性。Preparation of fucoidan oligosaccharides from Sargassum fusiforme using the “layer by layer” degradation strategy and their binding study with HA proteins of influenza A viruses（Carbohydrate Polymers， 2025）基因芯片扫描分析-SARS病毒突变体检测作者：意大利国家化学科学与技术研究所应用：作者使用微阵列生物芯片扫描分析仪-InnoScan，对核酸芯片进行荧光信号扫描和分析，对SARS病毒的突变体进行分型检测 Blastocyst euploidy rates in low-prognosis patients according to the POSEIDON criteria: a retrospective analysis of 3016 embryos（Biosensors , 2023）单细胞scWestern免疫印迹芯片扫描分析检测采用单细胞蛋白免疫印迹检测技术（scWesterns）对单细胞进行靶蛋白检测代表客户发表文献 Han, M.-M., et al., 8-Oxoguanine Modifications in Peripheral Leukocyte microRNAs Promote Age-related Inflammation by Remodeling Gene Regulatory Networks. 中国医学科学院老年医学研究所蛋白芯片 Li, J., et al., Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury. 郑州大学第一附属医院蛋白芯片 Zhao, Z., et al., Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling. 河北医科大学第二医院蛋白芯片 Li, Z., et al., Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab. 中国医学科学院北京协和医院蛋白芯片 Bi, Y., et al., Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. Cell Metabolism. 中国科学院生物物理研究所蛋白芯片 Liao, Q., et al., Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs. 南方医科大学基础医学院蛋白芯片 Hu, W., et al., Identification and Validation of Key Amino Acids in IgE Linear Epitopes of β-Lactoglobulin: Comparison of Recognition Patterns of Chinese Bovine Milk-Allergic Sera with Different Symptoms. 南昌大学蛋白芯片 Zhang, X., et al., A machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response. 兰州大学蛋白芯片 Liu, Y., et al., Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors. 西北大学多糖芯片 Better, J., et al., Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages. 德国吉森尤斯图斯 - 李比希大学核酸芯片 Sidharthan, V., et al., Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P 美国国家癌症研究所小分子化合物芯片 Tsuno, T., et al., Imeglimin suppresses glucagon secretion and induces a loss of alpha cell identity.群马大学分子与细胞调控研究所单细胞免疫印迹芯片 Foncy, J., et al., Dynamic inking of large-scale stamps for multiplexed microcontact printing and fabrication of cell microarrays. 法国图卢兹大学细胞芯片环亚产品环亚生物科技有限公司（APG BIO Ltd）成立于2011年，专注于引进国外创新技术和高品质仪器设备。主推产品包括全自动DNA核酸脉冲场电泳回收仪--美国Sage Science 代替手工切胶和磁珠，用于二代／三代／超长测序文库、常规分子实验的精准回收 24通道明场实时活细胞成像分析仪--德国innoME 6/24孔板分组对比实验，用于细胞、类器官的生长监测、划痕迁移、培养优化等超高通量、高密度微阵列生物芯片点样仪 --英国ArrayJet 单次可喷点上万种生物样品，制备最多1000张高密度生物芯片，用于高通量筛选皮升、纳升级高精度微阵列生物芯片点样仪--德国M2 Automation 生物传感器、微流控、微孔板、微柱、微针、覆膜、POCT芯片等点样，可灵活定制超高通量 SPRi分子互作仪--美国Plexera 表面等离子共振成像技术，无标记实时动力学检测，最多同时检测3840对分子互作超高精度组织原位蛋白功能定量分析系统--西班牙Hawk Biosystems 小于10nm距离的蛋白质相互作用定量验证，用于互作、翻译后修饰、肿瘤免疫等毛细管电泳生物制药分析系统--荷兰Prince technologies 纳升级全自动压力浓缩进样，全程控温，用于蛋白纯度／等电点测定、制药质控等更多产品咨询,请联系我们：环亚生物科技有限公司地址：上海市松江区莘砖公路518号9幢502室电话：021-54583565 邮箱：marketing@apgbio.com 官网：www.apgbio.com 扫码关注我们产品咨询 | 资料获取线上报修 | 简历投递

2026-09-07

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InnoScan 1100 0.5微米/高分辨率/三色荧光/基因芯片/蛋白芯片/糖芯片/化合物芯片/细胞组织芯片/超高密度微阵列生物芯片扫描分析仪

法国 Innopsys 公司成立于1999年，总部位于法国的图卢兹，并设立美国芝加哥分部 20多年专注于激光共聚焦微阵列生物芯片扫描分析仪荧光检测硬件和软件的自主开发与生产作为超高分辨率微阵列生物芯片扫描分析仪的制造厂商，全球装机客户已超过600家 InnoScan 1100 0.5微米/高分辨率/三色荧光微阵列芯片扫描仪采用先进的激光共聚焦扫描光路和高灵敏度PMT检测器，进行多通道荧光检测有效降低荧光光漂白现象以及信号损失，还可有效缩短扫描时间 01 技术原理共聚焦光路实时共聚焦激光光路，保证高分辨率和高灵敏度，扫描结果更高清动态范围广动态范围可扩展至10⁶ bit，避免过度饱和或低信号假阴性 02 产品特点高灵敏度：实时共聚焦光路，极大提高灵敏度高分辨率： 0.5μm/pixel-40μm/pixel可调高信噪比：线扫描方式，图片无拼痕、无需阴影矫正，有效降低荧光的光漂白现象及信号损失高通量：可实现24片玻片自动进样激光光源：488nm(蓝)，532nm(绿)和635nm(红) 扫描通道：可实现三通道同时扫描，三个独立的PMT可同步检测扫描速度快：在1μm/pixel分辨率下，10.5min即可完成22mmX22mm芯片面积的扫描 03 应用方向寡核苷酸芯片、核酸芯片、基因芯片扫描：对基因功能分析、基因表型分析、基因突变分析等蛋白质芯片、多肽芯片、抗原抗体芯片扫描：对蛋白表达水平检测、功能蛋白筛选、蛋白质相互作用等糖芯片、多糖芯片、糖蛋白芯片扫描：进行糖功能学、糖蛋白、植物凝集素等研究小分子化合物芯片扫描：进行配体筛选、药物研发、疾病靶点筛选细胞组织芯片扫描：细胞代谢机制、信号传导机制；组织间蛋白表达差异等 04 应用案例蛋白质芯片扫描分析-牙周炎机制研究作者：北京大学口腔预防学系国家口腔临床研究中心应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，为探究枯草芽孢杆菌 R0179 是否能逆转牙龈卟啉单胞菌刺激诱导的 TLR、下游 p-NF-κB 及促炎细胞因子表达变化。 Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas GingivalisInduced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis（Inflammation，2025）蛋白质芯片扫描分析-结直肠癌靶点发现作者：南方医科大学联合广州医科大学附属肿瘤医院应用：使用法国Innopsys激光共聚焦荧光微阵列生物芯片扫描仪进行荧光信号检测及分析，揭示肠道微生物代谢产物4-HPA通过激活JAK2/STAT3信号通路，促进结直肠癌细胞分泌趋化因子CXCL3，从而招募免疫抑制性的多形核髓源性抑制细胞（PMN-MDSCs），抑制CD8T细胞的抗肿瘤活性，最终促进结直肠癌进展及免疫抑制微环境的形成。 Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs（J Clin Invest，2025）小分子化合物芯片扫描分析-RNA酶结合位点筛选作者：美国国家癌症研究所化学生物学实验室应用：作者使用微阵列生物芯片扫描分析仪-InnoScan 1100AL在635nm处对小分子化合物微阵列芯片进行荧光信号扫描和分析，通过研究发现了一种可以下调DHX15蛋白表达的化合物，该方法为新药研发过程中先导化合物的发现提供了一种新的研究策略。 Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex（ACS Medicinal Chemistry Letters, 2025）多糖芯片扫描分析-流感病毒感染研究作者：西北大学糖生物学与糖工程重点实验室应用：作者将羊栖菜来源岩藻多糖（硫酸化多糖）制备为寡糖芯片，孵育甲型流感病毒血凝素（HA）蛋白，荧光标记后扫描，分析多糖与病毒蛋白的结合活性。Preparation of fucoidan oligosaccharides from Sargassum fusiforme using the “layer by layer” degradation strategy and their binding study with HA proteins of influenza A viruses（Carbohydrate Polymers， 2025）基因芯片扫描分析-SARS病毒突变体检测作者：意大利国家化学科学与技术研究所应用：作者使用微阵列生物芯片扫描分析仪-InnoScan，对核酸芯片进行荧光信号扫描和分析，对SARS病毒的突变体进行分型检测 Blastocyst euploidy rates in low-prognosis patients according to the POSEIDON criteria: a retrospective analysis of 3016 embryos（Biosensors , 2023）单细胞scWestern免疫印迹芯片扫描分析检测采用单细胞蛋白免疫印迹检测技术（scWesterns）对单细胞进行靶蛋白检测细胞芯片扫描作者：法国国家科学研究中心应用：作者使用微阵列生物芯片扫描分析仪-InnoScan，对细胞微阵列芯片进行荧光信号扫描和分析，用于制备细胞芯片方法学开发，细胞核用DRAQ5™染料（蓝色）标记，细胞质用GFP 蛋白（绿色）标记。 Dynamic inking of large-scale stamps for multiplexed microcontact printing and fabrication of cell microarrays（PLOS ONE , 2018）组织芯片扫描乳腺癌组织样本来源于Gustave Roussy Institute (France) 注：IS 1100 AL ，0.5µm/pixel 分辨率进行扫描.Panel A：绿色荧光染料标记细胞膜；红色染料标记血管Panel B：绿色荧光染料标记细胞膜；蓝色染料标记CD45淋巴球Panel C：2µm/pixel分辨率，扫描整张组织芯片 05 代表客户发表文献 Han, M.-M., et al., 8-Oxoguanine Modifications in Peripheral Leukocyte microRNAs Promote Age-related Inflammation by Remodeling Gene Regulatory Networks. 中国医学科学院老年医学研究所蛋白芯片 Li, J., et al., Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury. 郑州大学第一附属医院蛋白芯片 Zhao, Z., et al., Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling. 河北医科大学第二医院蛋白芯片 Li, Z., et al., Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab. 中国医学科学院北京协和医院蛋白芯片 Bi, Y., et al., Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. Cell Metabolism. 中国科学院生物物理研究所蛋白芯片 Liao, Q., et al., Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs. 南方医科大学基础医学院蛋白芯片 Hu, W., et al., Identification and Validation of Key Amino Acids in IgE Linear Epitopes of β-Lactoglobulin: Comparison of Recognition Patterns of Chinese Bovine Milk-Allergic Sera with Different Symptoms. 南昌大学蛋白芯片 Zhang, X., et al., A machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response. 兰州大学蛋白芯片 Liu, Y., et al., Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors. 西北大学多糖芯片 Better, J., et al., Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages. 德国吉森尤斯图斯 - 李比希大学核酸芯片 Sidharthan, V., et al., Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P 美国国家癌症研究所小分子化合物芯片 Tsuno, T., et al., Imeglimin suppresses glucagon secretion and induces a loss of alpha cell identity.群马大学分子与细胞调控研究所单细胞免疫印迹芯片 Foncy, J., et al., Dynamic inking of large-scale stamps for multiplexed microcontact printing and fabrication of cell microarrays. 法国图卢兹大学细胞芯片环亚产品环亚生物科技有限公司（APG BIO Ltd）成立于2011年，专注于引进国外创新技术和高品质仪器设备。主推产品包括全自动DNA核酸脉冲场电泳回收仪--美国Sage Science 代替手工切胶和磁珠，用于二代／三代／超长测序文库、常规分子实验的精准回收 24通道明场实时活细胞成像分析仪--德国innoME 6/24孔板分组对比实验，用于细胞、类器官的生长监测、划痕迁移、培养优化等超高通量、高密度微阵列生物芯片点样仪 --英国ArrayJet 单次可喷点上万种生物样品，制备最多1000张高密度生物芯片，用于高通量筛选皮升、纳升级高精度微阵列生物芯片点样仪--德国M2 Automation 生物传感器、微流控、微孔板、微柱、微针、覆膜、POCT芯片等点样，可灵活定制超高通量 SPRi分子互作仪--美国Plexera 表面等离子共振成像技术，无标记实时动力学检测，最多同时检测3840对分子互作超高精度组织原位蛋白功能定量分析系统--西班牙Hawk Biosystems 小于10nm距离的蛋白质相互作用定量验证，用于互作、翻译后修饰、肿瘤免疫等毛细管电泳生物制药分析系统--荷兰Prince technologies 纳升级全自动压力浓缩进样，全程控温，用于蛋白纯度／等电点测定、制药质控等更多产品咨询,请联系我们：环亚生物科技有限公司地址：上海市松江区莘砖公路518号9幢502室电话：021-54583565 邮箱：marketing@apgbio.com 官网：www.apgbio.com 扫码关注我们产品咨询 | 资料获取线上报修 | 简历投递

寡核苷酸临床申请

100 项与伊美格列明相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D11807	伊美格列明	A10B	DB12509

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
2型糖尿病	日本	Sumitomo Pharma Co., Ltd.	2021-06-23

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT07127094 (Pubmed \| Naunyn Schmiedebergs Arch Pharmacol)	临床1期	-	29	Test imeglimin hydrochloride tablet	淵願鹹構顧構願簾鏇範(鬱糧繭壓觸簾顧繭夢鹽) = 廠顧鬱選積構範構窪網鑰網艱鑰襯築襯壓繭鏇 (鑰選鏇選構積壓衊選窪 ) 更多	积极	2025-11-26
EUCTR2013-001539-35-HU (Pubmed) 人工标引	临床2期	2型糖尿病二线	59	imeglimin	膚襯範襯鬱餘觸廠築鹹(淵遞願糧獵獵鏇觸鏇餘) = 蓋獵壓繭艱醖糧構鹹襯窪廠鹽糧壓廠觸製醖蓋 (衊艱糧築衊襯願餘艱願 ) 更多	积极	2022-10-14
				Placebo	膚襯範襯鬱餘觸廠築鹹(淵遞願糧獵獵鏇觸鏇餘) = 網獵醖鹽積網積積壓夢窪廠鹽糧壓廠觸製醖蓋 (衊艱糧築衊襯願餘艱願 ) 更多
JPRN-JapicCTI-183846 (TIMES 3, Pubmed) 人工标引	临床3期	2型糖尿病	215	insulin+Imeglimin	齋築積襯壓簾選構窪範(醖鬱簾築襯鑰繭選選遞) = 鏇餘鬱膚襯鑰糧淵齋壓範獵築衊淵窪觸簾糧廠 (觸夢壓廠獵蓋憲願繭餘, -0.78 ~ -0.49)	积极	2022-01-04
				insulin+Placebo	齋築積襯壓簾選構窪範(醖鬱簾築襯鑰繭選選遞) = 鹽淵範艱簾願願醖鹽繭範獵築衊淵窪觸簾糧廠 (觸夢壓廠獵蓋憲願繭餘, -0.18 ~ 0.12)
JPRN-JapicCTI-173769 (TIMES 1, Pubmed \| Diabetes Care) 人工标引	临床3期	2型糖尿病	213	Imeglimin	醖衊蓋鬱蓋鬱獵網餘餘(廠製鹽膚鹽鬱齋觸製鹹) = 鹽觸鏇遞鏇構觸餘積觸衊簾鹹襯積淵鑰鑰廠窪 (醖蓋繭艱糧糧齋繭艱廠 ) 更多	积极	2021-04-01
				Placebo	鹽積積範範壓襯壓壓網(顧廠淵範鏇築齋鹹範範) = 簾淵壓鹽構艱艱憲齋繭顧膚網糧衊範鹽廠繭構 (淵遞壓選築鹽繭艱醖鹹 )
JPRN-JapicCTI-183846 (TIMES 3, EASD2020)	临床3期	2型糖尿病	215	Imeglimin 1000 mg	繭鑰鏇鹹鏇繭糧築簾廠(遞築遞簾築鏇壓齋餘糧) = 製鬱獵齋選夢獵選憲製齋憲醖選齋選鹹艱獵糧 (餘糧鏇憲醖願憲網壓繭, 0.10)	积极	2020-09-23